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https://www.readbyqxmd.com/read/29330596/cognitive-functioning-is-it-all-or-none
#1
Isabel M Introzzi, María M Richard S, Ana Comesaña, Ana García Coni
Under various circumstances, the cognitive system operates in a global manner that is not very precise and barely discriminatory. This form of operating has been described via a general principal that Diamond (Developmental Psychology 45:130-138, 2009) has denominated the All or None Hypothesis. This author has described a set of corollaries derived from this hypothesis that make it possible to verify it in each one of these domains. Although there is evidence of the global and non-discriminate way in which the cognitive system operates in populations of children, to date, there are no studies that have examined whether this mode of operation is also present in populations of adults...
January 12, 2018: Psychological Research
https://www.readbyqxmd.com/read/29329050/factors-influencing-the-severity-of-behavioral-phenotype-in-autism-spectrum-disorders-implications-for-research
#2
Mingyang Zou, Caihong Sun, Jia Wang, Jing Kang, Zhanbin Xu, Yongjuan Ma, Lei Chen, Xinxi Zhang, Wei Xia, Lijie Wu
The phenotypic heterogeneity of Autism Spectrum Disorders (ASD) presents particular research challenges in the assessment of symptom severity, while the standardized Autism Diagnostic Observation Schedule (ADOS) scores present a severity metric, namely calibrated severity scores (CSS) that are relatively impervious to individual characteristics. To date, no studies have examined the convergent validity of CSS in Chinese sample populations. The present study investigated the validity of the ADOS-CSS using a sample of 321 children aged 2-18 years with ASD, and developed upon existing literature examining the influence of non-ASD-specific characteristics on other types of measures including Autism Diagnostic Interview-Revised (ADI-R), Social Responsiveness Scale (SRS), and Vineland Adaptive Behavior Scales (VABS)...
January 5, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29328870/agent-based-modeling-in-public-health-current-applications-and-future-directions
#3
Melissa Tracy, Magdalena Cerdá, Katherine M Keyes
Agent-based modeling is a computational approach in which agents with a specified set of characteristics interact with each other and with their environment according to predefined rules. We review key areas in public health where agent-based modeling has been adopted, including both communicable and noncommunicable disease, health behaviors, and social epidemiology. Wealso describe the main strengths and limitations of this approach for questions with public health relevance. Finally, we describe both methodologic and substantive future directions that we believe will enhance the value of agent-based modeling for public health...
January 12, 2018: Annual Review of Public Health
https://www.readbyqxmd.com/read/29328778/engineering-approaches-to-study-cellular-decision-making
#4
Pamela K Kreeger, Laura E Strong, Kristyn S Masters
In their native environment, cells are immersed in a complex milieu of biochemical and biophysical cues. These cues may include growth factors, the extracellular matrix, cell-cell contacts, stiffness, and topography, and they are responsible for regulating cellular behaviors such as adhesion, proliferation, migration, apoptosis, and differentiation. The decision-making process used to convert these extracellular inputs into actions is highly complex and sensitive to changes both in the type of individual cue (e...
January 12, 2018: Annual Review of Biomedical Engineering
https://www.readbyqxmd.com/read/29326522/fragile-x-syndrome-a-rare-case-report-with-unusual-oral-features
#5
Prayas Ray, Arpanna Singh, Jayanta Kumar Dash, Prasanna Kumar Sahoo, Jitendra Kumar Dash
Fragile X syndrome (FXS) is a rare variant of special health-care need demonstrating delayed developmental milestones and associated with intellectual and emotional disabilities ranging from learning problem to mental retardation. The syndrome is usually not diagnosed until 8-9 years of age since the clinical manifestations of the syndrome are greatly attenuated in childhood. The physical characteristics such as facial features, hyperactivity, attention deficit, autistic behavior, and macroorchidism are quite evident in younger age group...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29326171/abdominal-vagal-afferents-modulate-the-brain-transcriptome-and-behaviors-relevant-to-schizophrenia
#6
Melanie Klarer, Jean-Philippe Krieger, Juliet Richetto, Ulrike Weber-Stadlbauer, Lydia Günther, Christine Winter, Myrtha Arnold, Wolfgang Langhans, Urs Meyer
Reduced activity of vagal efferents has long been implicated in schizophrenia and appears to be responsible for diminished parasympathetic activity and associated peripheral symptoms such as low heart rate variability and cardiovascular complications in affected individuals. In contrast, only little attention has been paid to the possibility that impaired afferent vagal signaling may be relevant for the disorder's pathophysiology as well. The present study explored this hypothesis using a model of subdiaphragmatic vagal deafferentation (SDA) in male rats...
January 11, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29326033/the-contribution-of-gender-differences-in-motor-behavioral-and-cognitive-features-to-functional-capacity-independence-and-quality-of-life-in-patients-with-huntington-s-disease
#7
Daniel Zielonka, Michał Ren, Giuseppe De Michele, Raymund A C Roos, Ferdinando Squitieri, Anna Rita Bentivoglio, Jerzy T Marcinkowski, G Bernhard Landwehrmeyer
INTRODUCTION: Huntington's disease (HD) is a neurodegenerative autosomal dominant disorder affecting patients' motor, behavioral and cognitive domains leading to total dependency for activities of daily life. This study compares whether gender differences in motor, cognitive and behavioral symptoms affect function and how functional impairment affects quality of life (QoL). METHODS: We recruited 2191 subjects from the REGISTRY data base that provides personal data, HD age of onset, visit date, CAG mutation size, UHDRS and TFC scores from at least one visit...
January 5, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29325154/growth-and-carbon-balance-are-differently-regulated-by-tree-and-shoot-fruiting-contexts-an-integrative-study-on-apple-genotypes-with-contrasted-bearing-patterns
#8
Benoît Pallas, Sylvie Bluy, Jérôme Ngao, Sébastien Martinez, Anne Clément-Vidal, Jean-Jacques Kelner, Evelyne Costes
In plants, carbon source-sink relationships are assumed to affect their reproductive effort. In fruit trees, carbon source-sink relationships are likely to be involved in their fruiting behavior. In apple, a large variability in fruiting behaviors exists, from regular to biennial, which has been related to the within-tree synchronization vs desynchronization of floral induction in buds. In this study, we analyzed if carbon assimilation, availability and fluxes as well as shoot growth differ in apple genotypes with contrasted behaviors...
January 9, 2018: Tree Physiology
https://www.readbyqxmd.com/read/29324735/influence-of-c-src-on-hypoxic-resistance-to-paclitaxel-in-human-ovarian-cancer-cells-and-reversal-of-fv-429
#9
Qinglong Guo, Lu Lu, Yan Liao, Xiaoping Wang, Yi Zhang, Yicheng Liu, Shaoliang Huang, Haopeng Sun, Zhiyu Li, Li Zhao
SRC family kinase was documented to have vital roles in adjusting cancer cell malignant behaviors. To date, the role of c-Src, a member of SRC family kinase, in resistance to paclitaxel in human ovarian cancer cells under hypoxia has not been investigated. In the present study, we discovered that hypoxic environment suppressed paclitaxel-induced G2/M phase arrest and blockade of c-Src improved ovarian cancer cells' sensitivity to paclitaxel. FV-429, a derivative of natural flavonoid wogonin, could suppress gene expression and activation of c-Src, followed by deteriorated Stat3 nuclear translocation and its binding to HIF-1α, resulting in paclitaxel resistance reversal through G2/M arrest potentiation...
January 11, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29323610/the-debate-about-electronic-cigarettes-harm-minimization-or-the-precautionary-principle
#10
Lawrence W Green, Jonathan E Fielding, Ross C Brownson
Two contrasting reviews (authored by Abrams et al. and Glanz & Bareham) in this volume have reached opposing conclusions on the effects of electronic cigarettes in a debate that is dividing the scientific and professional communities that have devoted careers to controlling the manufacture, advertising, sale, and use of combustible cigarettes. The research on the types, degree, and extent of harm from e-cigarettes is far from complete and, together with trends in teenage smoking and vaping, has raised new questions and prospects about the potential benefits that the new electronic products offer smokers of combustible cigarettes in quitting or at least cutting back on the known risks associated with the traditional forms of smoking...
January 11, 2018: Annual Review of Public Health
https://www.readbyqxmd.com/read/29321971/processing-and-regulation-of-negative-emotions-in-anorexia-nervosa-an-fmri-study
#11
Maria Seidel, Joseph A King, Franziska Ritschel, Ilka Boehm, Daniel Geisler, Fabio Bernardoni, Matthias Beck, Sophie Pauligk, Ronald Biemann, Alexander Strobel, Thomas Goschke, Henrik Walter, Veit Roessner, Stefan Ehrlich
Theoretical models and recent advances in the treatment of anorexia nervosa (AN) have increasingly focused on the role of alterations in the processing and regulation of emotions. To date, however, our understanding of these changes is still limited and reports of emotional dysregulation in AN have been based largely on self-report data, and there is a relative lack of objective experimental evidence or neurobiological data. The current functional magnetic resonance imaging (fMRI) study investigated the hemodynamic correlates of passive viewing and voluntary downregulation of negative emotions by means of the reappraisal strategy detachment in AN patients...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29321703/executive-functions-of-obsessive-compulsive-disorder-and-panic-disorder-patients-in-comparison-to-healty-controls
#12
Emel Kurt, Erol Yildirim, Volkan Topçuoğlu
Introduction: Patients with obsessive compulsive disorder (OCD) have impaired cognitive functions, including attention, verbal and visual memory, and visual-spatial abilities as well as executive function But some studies did not show any disturbance in executive function of patients with OCD. To date, only few studies have been conducted on neuropsychological functioning of patients with panic disorder (PD). There are limited studies to reach a definite conclusion on executive functions of patients with OCD and those with PD...
December 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/29321654/motivating-cord-blood-donation-with-information-and-behavioral-nudges
#13
Daniela Grieco, Nicola Lacetera, Mario Macis, Daniela Di Martino
Umbilical cord blood is a source of hematopoietic stem cells essential to treat life-threatening diseases, such as leukemia and lymphoma. However, only a very small percentage of parents donate upon delivery. The decision to donate the cord blood occurs at a very specific time and when parents likely experience emotional, informational, and decisional overloads; these features of cord blood donation make it different from other pro-social activities. In collaboration with an OB-GYN clinic in Milan, Italy, we conducted the first randomized controlled trial that applies tools from behavioral science to foster cord blood donation, and quantified the gains that informational and behavioral "nudges" can achieve...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29313138/do-psychoactive-drugs-have-a-therapeutic-role-in-compulsivity-studies-on-schedule-induced-polydipsia
#14
Elena Martín-González, Ángeles Prados-Pardo, Santiago Mora, Pilar Flores, Margarita Moreno
RATIONALE: Clinical studies have shown that some psychoactive recreational drugs have therapeutic applications in anxiety, depression, and schizophrenia. However, to date, there are few studies on the therapeutic potential efficacy of recreational drugs in compulsive neuropsychiatric disorders. OBJECTIVES: We explored the therapeutic potential of different psychoactive and psychedelic drugs in a preclinical model of compulsive behavior. METHODS: Outbred male Wistar rats were selected as either high (HD) or low (LD) drinkers according to their behavior in schedule-induced polydipsia (SIP)...
January 8, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29311321/women-live-longer-than-men-even-during-severe-famines-and-epidemics
#15
Virginia Zarulli, Julia A Barthold Jones, Anna Oksuzyan, Rune Lindahl-Jacobsen, Kaare Christensen, James W Vaupel
Women in almost all modern populations live longer than men. Research to date provides evidence for both biological and social factors influencing this gender gap. Conditions when both men and women experience extremely high levels of mortality risk are unexplored sources of information. We investigate the survival of both sexes in seven populations under extreme conditions from famines, epidemics, and slavery. Women survived better than men: In all populations, they had lower mortality across almost all ages, and, with the exception of one slave population, they lived longer on average than men...
January 8, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29305016/-design-and-validation-of-the-scale-for-the-detection-of-violence-in-courtship-in-young-people-in-the-sevilla-university-spain
#16
María Ángeles García-Carpintero, Javier Rodríguez-Santero, Ana María Porcel-Gálvez
OBJECTIVE: To design and validate a specific instrument to detect exercised and suffered in the relations of young couples in violence. METHOD: Descriptive study of validation clinimetric. Stratified by sex and area of knowledge, which was adopted as inclusion criteria have or have had any relationship. The sample consisted of 447 subjects. RESULTS: We obtained the Multidimensional Scale Dating Violence (EMVN), 32 items with three dimensions: physical and sexual assault, behavior control (cyberbullying, surveillance and harassment) and abuse psicoemocional (disparagement and domination), as a victim or as aggressor...
January 2, 2018: Gaceta Sanitaria
https://www.readbyqxmd.com/read/29304348/suicide-specific-rumination-relates-to-lifetime-suicide-attempts-above-and-beyond-a-variety-of-other-suicide-risk-factors
#17
Megan L Rogers, Thomas E Joiner
Suicide-specific rumination, defined as a mental fixation on one's suicidal thoughts, intentions, and plans, may be an important predictor of suicidal behavior. To date, suicide-specific rumination has demonstrated convergence with, yet distinction from, a variety of suicide risk factors, and differentiated suicide attempters from ideators. However, no research has examined whether suicide-specific rumination is associated with lifetime suicide attempts above and beyond the presence of a host of other relevant suicide risk factors...
December 26, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29304059/space-use-by-4-strains-of-laying-hens-to-perch-wing-flap-dust-bathe-stand-and-lie-down
#18
Elizabeth R Riddle, Ahmed B A Ali, Dana L M Campbell, Janice M Siegford
The laying hen industry is implementing aviary systems intended to improve welfare by providing hens with more space and resources to perform species-specific behaviors. To date, limited research has examined spatial requirements of various strains of laying hens for performing key behaviors and none has been conducted within an alternative housing system. This study investigated the amount of space used by 4 strains of laying hens (Hy-Line Brown [HB], Bovans Brown [BB], DeKalb White [DW], and Hy-Line W36) to perform 5 different behaviors in the litter area of a commercial-style aviary...
2018: PloS One
https://www.readbyqxmd.com/read/29303571/an-allosterically-regulated-four-state-macrocycle
#19
Andrea I d'Aquino, Ho Fung Cheng, Joaquín Barroso-Flores, Zachary S Kean, Jose Mendez-Arroyo, C Michael McGuirk, Chad A Mirkin
Macrocycles capable of host-guest chemistry are an important class of structures that have attracted considerable attention because of their utility in chemical separations, analyte sensing, signal amplification, and drug delivery. The deliberate design and synthesis of such structures are rate-limiting steps in utilizing them for such applications, and coordination-driven supramolecular chemistry has emerged as a promising tool for rapidly making large classes of such systems with attractive molecular recognition capabilities and, in certain cases, catalytic properties...
January 5, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29302670/4d-printing-of-a-self-morphing-polymer-driven-by-a-swellable-guest-medium
#20
Jheng-Wun Su, Xiang Tao, Heng Deng, Cheng Zhang, Shan Jiang, Yuyi Lin, Jian Lin
There is a significant need of advanced materials that can be fabricated into functional devices with defined three-dimensional (3D) structures for application in tissue engineering, flexible electronics, and soft robotics. This need motivates an emerging four-dimensional (4D) printing technology, by which printed 3D structures consisting of active materials can transform their configurations over time in response to stimuli. Despite the ubiquity of active materials in performing self-morphing processes, their potential for 4D printing has not been fully explored to date...
January 5, 2018: Soft Matter
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