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https://www.readbyqxmd.com/read/27912794/a-genetic-risk-score-composed-of-rheumatoid-arthritis-risk-alleles-hla-drb1-haplotypes-and-response-to-tnfi-therapy-results-from-a-swedish-cohort-study
#1
Xia Jiang, Johan Askling, Saedis Saevarsdottir, Leonid Padyukov, Lars Alfredsson, Sebastien Viatte, Thomas Frisell
BACKGROUND: To prevent debilitating and irreversible joint damage, rheumatoid arthritis (RA) is often treated with tumor necrosis factor inhibitor (TNFi), but many patients do not respond to this costly therapy. Few predictors for response are known, and it has been proposed that genetic factors which influence the development of RA may also influence disease severity and response to therapy. Several previous studies have attempted to confirm this but results remain inconclusive. We expand on previous studies by including more RA risk alleles, and maximize power by combining them into a genetic risk score...
December 3, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27905890/low-and-declining-attack-rates-of-imported-typhoid-fever-in-the-netherlands-1997-2014-in-spite-of-a-restricted-vaccination-policy
#2
F S T Suryapranata, M Prins, G J B Sonder
BACKGROUND: Typhoid fever mainly occurs in (sub) tropical regions where sanitary conditions remain poor. In other regions it occurs mainly among returning travelers or their direct contacts. The aim of this study was to evaluate the current Dutch guidelines for typhoid vaccination. METHOD: Crude annual attack rates (AR) per 100,000 Dutch travelers were calculated during the period 1997 to 2014 by dividing the number of typhoid fever cases by the estimated total number of travelers to a specific country or region...
December 1, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27900151/can-the-otago-falls-prevention-program-be-delivered-by-video-a-feasibility-study
#3
Jennifer C Davis, Chun Liang Hsu, Winnie Cheung, Penny M A Brasher, Linda C Li, Karim M Khan, Jonathan Sykes, Dawn A Skelton, Teresa Liu-Ambrose
OBJECTIVES: We assessed the feasibility of delivering the Otago Exercise Programme (OEP) via an interactive DVD (ie, OEP-DVD) in combination with monthly physical therapist phone calls to older adults. DESIGN: This pre-post (baseline and 6-month follow-up) study included an intervention group (n=61) based in a rural location and a control group (n=21) based in a city. SETTING: Sechelt and Vancouver, British Columbia. PARTICIPANTS: 82 community-dwelling adults ≥75 years...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27899531/a-respiratory-therapist-disease-management-program-for-patients-hospitalized-with-copd
#4
Patty C Silver, Marin H Kollef, Darnetta Clinkscale, Peggy Watts, Robin Kidder, Brittany Eads, Debbie Bennett, Carolyn Lora, Michael Quartaro
BACKGROUND: Patients with COPD often require repeated emergency department visits and hospitalizations for COPD exacerbations. Such readmissions increase health-care costs and expose COPD patients to the added risks of nosocomial infections and increased mortality. METHODS: To determine whether a respiratory therapist (RT) disease management program could reduce re-hospitalization and emergency department visits, a prospective, single-center, unblinded, randomized trial was performed...
November 29, 2016: Respiratory Care
https://www.readbyqxmd.com/read/27898526/uptake-of-hiv-pre-exposure-prophylaxis-prep-in-a-national-cohort-of-gay-and-bisexual-men-in-the-united-states-the-motivational-prep-cascade
#5
Jeffrey T Parsons, H Jonathon Rendina, Jonathan M Lassiter, Thomas H F Whitfield, Tyrel J Starks, Christian Grov
OBJECTIVES: The HIV care cascade provides milestones to track the progress of HIV-positive people from seroconversion through viral suppression. We propose a Motivational PrEP Cascade involving five stages based upon the Transtheoretical Model of Change. METHODS: We analyzed data from 995 men in One Thousand Strong, a longitudinal study of a national panel of HIV-negative gay and bisexual men in the United States. RESULTS: Nearly all (89%) participants were sexually active in the past 3 months, and 65% met CDC criteria for PrEP candidacy...
November 24, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27894229/-self-reported-experience-in-patients-treated-with-hepatitis-c-direct-acting-antivirals
#6
Irene Cañamares Orbis, Javier Saez de la Fuente, Ismael Escobar Rodriguez, Concepción Esteban Alba, Ana Such Díaz, Ismael Escobar Rodríguez
BACKGROUND AND OBJECTIVE: To learn about and analyze the self-reported treatment experience of HCV patients who started treatment with direct acting antivirals agents (DAA), at a real-time, proactive and integrated into the pharmaceutical care healthcare process, using a prospective questionnaire completed by patients as clinical tool. MATERIAL AND METHODS: Observational and cross-sectional study conducted between April (start of the National Strategic Plan) and December 2015 in the Outpatient Pharmacy Service...
November 1, 2016: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/27893603/young-low-risk-heterosexual-clients-prefer-a-chlamydia-home-collection-test-to-a-sexually-transmitted-infection-clinic-visit-in-amsterdam-the-netherlands-a-cross-sectional-study
#7
Martijn S van Rooijen, Rik H Koekenbier, Alfons Hendriks, Henry J C de Vries, Petra van Leeuwen, Maaike G van Veen
BACKGROUND: Home-based self-collection of specimens for urogenital and anorectal chlamydia testing has been proven feasible and acceptable. We studied the efficiency of chlamydia home collection kits for young low-risk persons to optimize care at the Amsterdam sexually transmitted infection (STI) clinic. METHODS: Low-risk heterosexual persons under 25 years submitting an appointment request online were offered 3 different ways of chlamydia testing: (1) receiving a home collection kit, (2) coming to the clinic without, or (3) with sexual health counseling...
November 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27888789/reliability-and-minimal-detectable-change-in-foot-pressure-measurements-in-typically-developing-children
#8
Timothy Niiler, Chris Church, Nancy Lennon, John Henley, Ameeka George, Daveda Taylor, Angelica Montes, Freeman Miller
BACKGROUND: In pedobarography, clinically meaningful comparison of measurements within or between subjects is limited by data variability and measurement error. This study aims to determine the components of the minimal detectable change (MDC) in impulse across all foot regions and the reliability of these measures. METHODS: A convenience sample of foot pressures from 108 visits by normal, healthy subjects aged 2-17 years was studied. Each subject had three pedobarograph measurements taken per foot, with six subjects returning for a second visit for assessment of day-to-day variability...
October 22, 2016: Foot
https://www.readbyqxmd.com/read/27879949/single-center-experience-with-vascular-closure-devices-in-real-world-endovascular-peripheral-interventions
#9
Bruno Freitas, Sabine Steiner, Yvonne Bausback, Holger Staab, Daniela Branzan, Ursula Banning-Eichenseer, Andrej Schmidt, Dierk Scheinert
BACKGROUND: To evaluate the efficacy and safety of vascular closure devices(VCDs) in non-cardiac endovascular interventions. METHODS: Retrospective analysis of consecutive patients submitted to endovascular interventions, with deployment of 2327 vascular closure devices. Demographic, clinical/periprocedural, post-operative, complication and reintervention data were reviewed. RESULTS: 2107 patients (1409(66.9%) men) were included. Perclose ProGlide®(Abbott Vascular, CA,USA) was employed 1683 times(72...
November 23, 2016: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/27866873/factors-associated-with-the-uptake-of-and-adherence-to-hiv-pre-exposure-prophylaxis-in-people-who-have-injected-drugs-an-observational-open-label-extension-of-the-bangkok-tenofovir-study
#10
Michael Martin, Suphak Vanichseni, Pravan Suntharasamai, Udomsak Sangkum, Philip A Mock, Benjamaporn Chaipung, Dararat Worrajittanon, Manoj Leethochawalit, Sithisat Chiamwongpaet, Somyot Kittimunkong, Roman J Gvetadze, Janet M McNicholl, Lynn A Paxton, Marcel E Curlin, Timothy H Holtz, Taraz Samandari, Kachit Choopanya
BACKGROUND: Results of the randomised, double-blind, placebo-controlled Bangkok Tenofovir Study (BTS) showed that taking tenofovir daily as pre-exposure prophylaxis (PrEP) can reduce the risk of HIV infection by 49% in people who inject drugs. In an extension to the trial, participants were offered 1 year of open-label tenofovir. We aimed to examine the demographic characteristics, drug use, and risk behaviours associated with participants' uptake of and adherence to PrEP. METHODS: In this observational, open-label extension of the BTS (NCT00119106), non-pregnant, non-breastfeeding, HIV-negative BTS participants, all of whom were current or previous injecting drug users at the time of enrolment in the BTS, were offered daily oral tenofovir (300 mg) for 1 year at 17 Bangkok Metropolitan Administration drug-treatment clinics...
November 17, 2016: Lancet HIV
https://www.readbyqxmd.com/read/27865485/comparison-of-the-effectiveness-of-stress-echocardiography-versus-myocardial-perfusion-imaging-in-patients-presenting-to-the-emergency-department-with-low-risk-chest-pain
#11
Rhian Davies, Guodong Liu, Christopher Sciamanna, William R Davidson, Douglas L Leslie, Andrew J Foy
The aim of this study was to compare clinically relevant cardiovascular outcomes and downstream resource utilization associated with stress echocardiography (SE) and myocardial perfusion imaging (MPI) in emergency department patients with low-risk chest pain. This was a retrospective analysis of health insurance claims data for a national sample of privately insured patients over the period January 1 to December 31, 2011. Subjects were selected who presented to the emergency department with a primary or secondary diagnosis of chest pain and underwent either SE or MPI...
December 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27861929/does-treatment-of-paradoxical-vocal-fold-movement-disorder-decrease-asthma-medication-use
#12
Scott Kramer, Brad deSilva, L Arick Forrest, Laura Matrka
OBJECTIVES/HYPOTHESIS: To determine whether diagnosis and treatment of paradoxical vocal fold movement disorder (PVFMD) leads to decreased asthma medication use. Secondary objectives include determining initial rate of asthma medication use, characterizing symptom improvement, and correlating with pulmonary function testing (PFT). STUDY DESIGN: Prospective observational study. METHODS: Patients newly diagnosed with PVFMD at a single institution were recruited to participate...
November 15, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27858922/emphysematous-cholecystitis-in-a-young-male-without-predisposing-factors-a-case-report
#13
Ming-Yu Chen, Chen Lu, Yi-Fan Wang, Xiu-Jun Cai
This report describes the diagnosis and treatment for Emphysematous cholecystitis (EC) without predisposing factors, and reviews the current literature.A 49-year-old male without predisposition presented to emergency department with a two-day history of sudden onset abdominal pain, hypertension and received empirical antibiotics with Imipenem/Cilastatin 0.5 g via intravenous route every 8 hours. Computed tomography (CT)-scan revealed that air encircling gallbladder is the most important and accurate evidence for EC diagnosis...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27857899/hypoglycemia-and-revisable-st-elevation-induced-by-movento
#14
Mohammad Moshiri, Seyed Reza Mousavi, Leila Etemad
Spirotetramat (STM), an active ingredient of insecticide Movento 100 suspension concentrate (M100), is an inhibitor of acetyl-CoA carboxylase (ACC). The ACC is catalyst of acetyl-CoA to malonyl-CoA (MCA) reaction. MCA is the rate limiting steps of fatty acid biosynthesis. An 18-years-old man, who was referred to our ward from a local hospital, ingested 100 ml of M100, 18 h before. When we visited him, he was confused with stable vital signs and complained of vomiting and epigastric discomfort. He experienced hypoglycemia (blood sugar = 31 mg/dl) that was treated by hypertonic 20% dextrose serum and continued by maintenance DW10% (100 ml/h) up to 3 h...
October 2016: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/27853919/care-coordination-for-community-transitions-for-individuals-post-stroke-returning-to-low-resource-rural-communities
#15
Patrick Kitzman, Keisha Hudson, Violet Sylvia, Frances Feltner, Johnnie Lovins
High rates of hospital readmissions have been shown within 12 months post-discharge from inpatient rehabilitation following stroke. Multiple studies coupled with our previous work indicate a need for care support for stroke survivors' transitions to the community. The Kentucky Care Coordination for Community Transitions (KC(3)T) program was developed to provide access to medical, social, and environmental services to support community transitions for individuals with neurological conditions and their caregivers living in Kentucky...
November 16, 2016: Journal of Community Health
https://www.readbyqxmd.com/read/27847770/delayed-rebleeding-of-cerebral-aneurysm-misdiagnosed-as-traumatic-subarachnoid-hemorrhage
#16
Seung-Yoon Song, Dae-Won Kim, Jong-Tae Park, Sung-Don Kang
An intracranial saccular aneurysm is uncommonly diagnosed in a patient with closed head trauma. We herein present a patient with delayed rebleeding of a cerebral aneurysm misdiagnosed as traumatic subarachnoid hemorrhage (SAH). A 26-year-old female visited our emergency department because of headache after a motorcycle accident. Brain computed tomography (CT) showed a right-side dominant SAH in Sylvian fissure. Although traumatic SAH was strongly suggested because of the history of head trauma, we performed a CT angiogram to exclude any vascular abnormalities...
September 2016: Journal of Cerebrovascular and Endovascular Neurosurgery
https://www.readbyqxmd.com/read/27832580/trends-and-predictors-of-recent-hiv-testing-over-22-years-among-a-clinic-sample-of-men-who-have-sex-with-men-in-south-australia
#17
Bin Li, Peng Bi, Alison Ward, Charlotte Bell, Christopher K Fairley
Increasing the frequency of HIV testing is crucial for effective HIV prevention and care. The aim of the present study was to determine whether there has been a change in HIV testing among men who have sex with men (MSM) at the South Australia Specialist Sexual Health (SASSH) clinic over the past two decades. Methods: Computerised medical records of MSM who attended the SASSH at their first visit between 1994 and 2015 were used to determine whether HIV testing had changed among MSM. First HIV tests in each calendar year and return tests within 12 months were analysed...
November 11, 2016: Sexual Health
https://www.readbyqxmd.com/read/27830258/some-innovative-approaches-for-public-health-and-epidemiology-informatics
#18
L Toubiana, N Griffon
OBJECTIVES: Summarize excellent current research published in 2015 in the field of Public Health and Epidemiology Informatics. METHODS: The complete 2015 literature concerning public health and epidemiology informatics has been searched in PubMed and Web of Science, and the returned references were reviewed by the two section editors to select 14 candidate best papers. These papers were then peer-reviewed by external reviewers to allow the editorial team an enlightened selection of the best papers...
November 10, 2016: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/27821643/deprivation-occupational-hazards-and-perinatal-outcomes-in-pregnant-workers
#19
J-B Henrotin, M Vaissière, M Etaix, M Dziurla, A Radauceanu, S Malard, D Lafon
BACKGROUND: Recent global economic difficulties have widened social inequalities, but their impact on pregnant workers is not known. AIMS: To investigate the association between deprivation, exposure to occupational hazards and adverse perinatal outcomes in pregnant workers. METHODS: A cross-sectional study performed in 2014 in French occupational health services. Eligible workers were women who had worked during their pregnancy and had a medical visit by occupational health physicians (OHPs) after delivery and at the time of returning to work...
November 7, 2016: Occupational Medicine
https://www.readbyqxmd.com/read/27818116/health-supply-utilization-at-a-boy-scout-summer-camp-an-evaluation-for-improvement-and-preparedness
#20
Ross T Miller, Bradley E Barth
OBJECTIVE: To describe the health conditions treated by a health services center at a Boy Scout summer camp and make recommendations for appropriate resources and supplies. METHODS: We conducted a retrospective review of health center utilization at a Boy Scout camp in central Missouri during the summers of 2012 and 2013. Health logbook data were compiled and analyzed using descriptive and comparative statistics. RESULTS: During the study period 19,771 camp participants made 1586 visits to the health care center...
December 2016: Wilderness & Environmental Medicine
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