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miRNA, microRNA, Colorectal cancer

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https://www.readbyqxmd.com/read/28812395/current-research-on-circular-rnas-associated-with-colorectal-cancer
#1
Penghui Wang, Xiaodong He
Representing a novel type of endogenous noncoding RNAs, circular RNAs (circRNAs) have recently gained much attention for their involvement in multiple biological processes. CircRNAs are ubiquitously expressed in eukaryotic cells and modulate gene expression by acting as sponges of microRNAs (miRNAs) or other proteins, such as RNA-binding proteins (RBPs). Due to their unique structure, circRNAs are more stable than linear RNAs. Expression profiles of circRNAs are associated with clinicopathological characteristics of colorectal cancer patients, such as differentiation, TNM classification and distant metastasis...
August 16, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28809863/dynamic-plasma-micrornas-are-biomarkers-for-prognosis-and-early-detection-of-recurrence-in-colorectal-cancer
#2
Zixu Yuan, Kelsey Baker, Mary W Redman, Lei Wang, Scott V Adams, Ming Yu, Brandon Dickinson, Karen Makar, Neli Ulrich, Jürgen Böhm, Michelle Wurscher, Maria Westerhoff, Steve Medwell, Ravi Moonka, Mika Sinanan, Alessandro Fichera, Kathy Vickers, William M Grady
BACKGROUND: Plasma microRNAs (miRNAs) are promising non-invasive biomarkers for colorectal cancer (CRC) prognosis. However, the published studies to date have yielded conflicting and inconsistent results for specific plasma miRNAs. METHODS: We have conducted a study using robust assays to assess a panel of nine miRNAs for CRC prognosis and early detection of recurrence. Plasma samples from 144 patients in a prospective CRC cohort study were collected at diagnosis, 6, 12, and 24 months after diagnosis...
August 15, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28808643/polymorphism-rs16917496-at-the-mir-502-binding-site-of-the-lysine-methyltransferase-5a-set8-and-its-correlation-with-colorectal-cancer-in-iranians
#3
Meysam Mosallayi, Miganoosh Simonian, Sharifeh Khosravi, Ahmad Reza Salehi, Mahsa Khodadoostan, Vahid Sebghatollahi, Azar Baradaran, Rasoul Salehi
BACKGROUND: One of the gene expression regulatory mechanisms is mediated by small noncoding RNAs called microRNA (miRNA). They interact with a recognition sequence located mostly in 3'-untranslated regions (3'-UTRs) of mRNAs. Polymorphisms in miRNAs recognition sequences could affect gene expression which in turn may alter disease susceptibility. SET8, a member of the SET domain-containing methyltransferase, acts in a variety of biological processes such as genomic stability. Here, we report correlation of rs16917496 polymorphism, located in the recognition sequence of miR-502 within 3'-UTR of SET8, with colorectal cancer (CRC) in Iranians...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28791386/microrna%C3%A2-630-promotes-cell-proliferation-and-inhibits-apoptosis-in-the-hct116-human-colorectal-cancer-cell-line
#4
Lijuan Zhang, Gang Feng, Xinyan Zhang, Yawen Ding, Xiaojuan Wang
Dysregulation of microRNAs (miRNAs) in colorectal cancer provides important opportunities for the development of future miRNA‑based therapies. The present study aimed to assess the role of miRNA‑630 (miR‑630) expression in colorectal cancer. HCT116 human colorectal cancer cells were transfected with miR‑630 inhibitor, mimic or control miRNA, and the effects of miR‑630 dysregulation on cell viability, proliferation and apoptosis were analyzed using MTT and bromodeoxyuridine assays, and an annexin V‑fluorescein isothiocyanate cell apoptosis kit, respectively...
August 3, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28771442/oncomir-17-5p-alarm-signal-in-cancer
#5
REVIEW
Madhusudhan Reddy Bobbili, Robert M Mader, Johannes Grillari, Hanna Dellago
Soon after microRNAs entered the stage as novel regulators of gene expression, they were found to regulate -and to be regulated by- the development, progression and aggressiveness of virtually all human types of cancer. Therefore, miRNAs in general harbor a huge potential as diagnostic and prognostic markers as well as potential therapeutic targets in cancer.The miR-17-92 cluster was found to be overexpressed in many human cancers and to promote unrestrained cell growth, and has therefore been termed onco-miR-1...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28767429/systematic-literature-review-and-clinical-validation-of-circulating-micrornas-as-diagnostic-biomarkers-for-colorectal-cancer
#6
Cheng Pan, Xuebing Yan, Hao Li, Linsheng Huang, Mingming Yin, Yongzhi Yang, Renyuan Gao, Leiming Hong, Yanlei Ma, Chenzhang Shi, Huanlong Qin, Peng Zhang
Because patients with colorectal cancer (CRC) are usually diagnosed at an advanced stage and current serum tumor markers have limited diagnostic efficacy, there is an urgent need to identify reliable diagnostic biomarkers. To better define the diagnostic potential of microRNAs (miRNAs) for CRC, we performed a comprehensive evaluation of reported circulating CRC miRNA markers. After a systematic literature review, we selected 30 candidate miRNAs and used quantitative real-time polymerase chain reaction to examine their expression in a training cohort of 120 plasma samples (CRC vs healthy controls (HC) = 60:60)...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28767179/upregulation-of-microrna-135b-and-microrna-182-promotes-chemoresistance-of-colorectal-cancer-by-targeting-st6galnac2-via-pi3k-akt-pathway
#7
Bing Liu, Yanfeng Liu, Lifen Zhao, Yue Pan, Yujia Shan, Yang Li, Li Jia
MicroRNAs (miRNAs) are increasingly involved in the development of drug resistance, including 5-fluorouracil (5-FU) resistance in colorectal cancer (CRC). Aberrant sialylation is correlated with human CRC. The study was to explore whether miR-135b and miR-182 modulated 5-FU chemoresistance of CRC by targeting ST6GALNAC2 via PI3K/AKT pathway. MiR-135b and miR-182 were found to be up-regulated in CRC tissues and 5-FU resistant CRC cell lines. Forced miR-135b and miR-182 expression also affected ST6GALNAC2 levels...
August 2, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28765596/a-polymorphism-in-abcc4-is-related-to-efficacy-of-5-fu-capecitabine-based-chemotherapy-in-colorectal-cancer-patients
#8
Qi Chen, Fanyi Meng, Lei Wang, Yong Mao, Huan Zhou, Dong Hua, Hongjian Zhang, Weipeng Wang
To investigate the association of microRNA (miRNA) binding-site polymorphisms in the drug transporter genes with the efficacy of 5-Fluorouracil (5-FU)/capecitabine-based chemotherapy in colorectal cancer (CRC), 6 polymorphisms were determined in 432 CRC patients by using DNA sequencing method. The impacts of the polymorphisms on the miRNA-mediated regulation of gene expression were evaluated by using the methods including quantitative real-time PCR, western blotting, and luciferase reporter assays. The effects of miRNA on the intracellular concentration and cytotoxicity of 5-FU in CRC cells were measured by high performance liquid chromatography conjected tandem mass spectrometry (HPLC-MS/MS) and MTT methods, respectively...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28751193/microrna-33a-and-let-7e-inhibit-human-colorectal-cancer-progression-by-targeting-st8sia1
#9
Yujia Shan, Yuejian Liu, Lifen Zhao, Bing Liu, Yang Li, Li Jia
Colorectal cancer (CRC) is one of the leading causes of cancer mortality worldwide. Aberrant sialylation is crucially involved in the progression of various types of cancer. MicroRNAs (miRNAs) have been broadly studied in cancer. MicroRNA-33a (miR-33a) and Has-let-7e (let-7e) are non-coding RNA that can reduce cell motility and viability in cancer. In this study, miR-33a and let-7e levels were confirmed to be significantly down-regulated in CRC samples (n=32) and drug resistant cell line (HCT-8/5-FU) compared with those in the matched adjacent tissues and drug sensitivity cell line (HCT-8)...
July 24, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28749470/mir-181d-and-c-myc-mediated-inhibition-of-cry2-and-fbxl3-reprograms-metabolism-in-colorectal-cancer
#10
Xiaofeng Guo, Yuekun Zhu, Xinya Hong, Mukun Zhang, Xingfeng Qiu, Zhenfa Wang, Zhongquan Qi, Xuehui Hong
Colorectal cancer (CRC) is the second major cause of tumor-related deaths. MicroRNAs (miRNAs) have pivotal roles in CRC progression. Here, we describe the effect of miR-181d on CRC cell metabolism and underlying molecular mechanism. Our data firmly demonstrated that knockdown of miR-181d suppressed CRC cell proliferation, migration, and invasion by impairing glycolysis. Mechanistically, miR-181d stabilized c-myc through directly targeting the 3'-UTRs of CRY2 and FBXL3, which subsequently increased the glucose consumption and the lactate production...
July 27, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28748218/autophagy-regulated-by-mirnas-in-colorectal-cancer-progression-and-resistance
#11
Andrew Fesler, Hua Liu, Ning Wu, Fei Liu, Peixue Ling, Jingfang Ju
The catabolic process of autophagy is an essential cellular function that allows for the breakdown and recycling of cellular macromolecules. In recent years, the impact of epigenetic regulation of autophagy by non-coding microRNAs (miRNAs) has been recognized in human cancer. In colorectal cancer, Autophagy plays critical roles in cancer progression as well as resistance to chemotherapy, and recent evidence demonstrates that miRNAs are directly involved in mediating these functions. In this review, we will focus on the recent advancements in the field of miRNA regulation of autophagy in colorectal cancer...
2017: Cancer Translational Medicine
https://www.readbyqxmd.com/read/28747561/mir-133b-suppresses-metastasis-by-targeting-hoxa9-in-human-colorectal-cancer
#12
Xiao Wang, Juyuan Bu, Xingwei Liu, Wenfeng Wang, Weihua Mai, Baojun Lv, Jinlin Zou, Xiangqiong Mo, Xiaoling Li, Jingyu Wang, Bin Niu, Yunping Fan, Bingzong Hou
Functions and mechanisms of microRNA (miRNA) involved in colorectal cancer (CRC) metastasis are largely unknown. Here, a miRNA microarray analysis was performed in CRC primary tissues and metastatic hepatic tissues to disclose crucial miRNA involved in CRC metastasis. MiR-133b was decreased and negatively correlated with metastasis in CRC. Overexpression of miR-133b significantly suppressed metastasis of CRC in vitro and in vivo. HOXA9 was identified as a direct and functional target of miR-133b. In addition, HOXA9 was negatively correlated with miR-133b and promoted CRC malignant progress...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28738328/a-novel-role-for-mir-520a-3p-in-regulating-egfr-expression-in-colorectal-cancer
#13
Rui Zhang, Rui Liu, Chang Liu, Yahan Niu, Jianguo Zhang, Baoliang Guo, Chen-Yu Zhang, Jing Li, Jie Yang, Xi Chen
BACKGROUND/AIMS: MicroRNAs (miRNAs) have been consistently demonstrated to be involved in colorectal cancer as either tumour oncogenes or tumour suppressors. However, the detailed role of miR-520a-3p in colorectal cancer remains poorly understood. METHODS: Quantitative RT-PCR and western blotting assays were used to measure miR-520a-3p and EGFR expression levels in colorectal cancer tissues, respectively. Luciferase reporter assay was employed to validate the direct targeting of EGFR by miR-520a-3p...
July 24, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28714414/role-of-mirna-in-lung-cancer-potential-biomarkers-and-therapies
#14
Xiaohong Du, Jitai Zhang, Juping Wang, Xiaoming Lin, Feng Ding
MicroRNAs (miRNAs) are small noncoding RNAs, which downregulate gene expression by repressing or degrading mRNA targets. Lung cancer (LC), together with liver and colorectal cancers are the three leading causes of cancer death worldwide, and 80% of LCs belong to non-small cell lung cancers (NSCLCs). Despite a great advancement in developing distinct and delicate tools for early diagnosis and targeted therapies over the last decade, only about 15% of the NSCLC patients eventually survived. MiRNAs are frequently dysregulated in carcinoma, including LC...
July 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28713947/microrna-582-promotes-tumorigenesis-by-targeting-phosphatase-and-tensin-homologue-in-colorectal-cancer
#15
Bin Song, Yanbin Long, Dong Liu, Wen Zhang, Chang Liu
A number of studies have implicated that a class of non‑coding RNAs named microRNAs (miRNAs or miRs) is associated with tumorigenesis and have identified miRNAs as promising targets for pharmaceutical intervention. Recently, the deregulated expression of miR‑582 in tumor cells has been reported. However, the exact function of miR‑582 in colorectal cancer (CRC) remains largely unknown. In thi study, we demonstrate that miR‑582 is extensively upregulated in CRC tissues and cell lines. The overexpression of miR‑582 significantly enhanced the proliferation and migration ability of the CRC cells...
July 6, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28711913/silencing-protein-kinase-c-%C3%AE-by-microrna-25-5p-activates-ampk-signaling-and-inhibits-colorectal-cancer-cell-proliferation
#16
Shihu Zhang, Yiyang Zhang, Qing Cheng, Zhaoqun Ma, Guanwen Gong, Zhengming Deng, Kun Xu, Gaoyuan Wang, Yousong Wei, Xiaoping Zou
Developing novel strategies against human colorectal cancer (CRC) cells is needed. Activation of AMP-activated protein kinase (AMPK) could possibly inhibit CRC cells. Protein kinase C ζ (PKCζ) is an AMPK negative regulator. Here we found that PKCζ expression was significantly elevated in human colon cancer tissues and CRC cells. PKCζ upregulation was correlated with AMPK in-activation and mTOR complex 1 (mTORC1) over-activation. Reversely, PKCζ shRNA knockdown activated AMPK signaling and inhibited HT-29 cell proliferation...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28693274/decreased-expression-of-mir-193a-3p-is-associated-with-poor-prognosis-in-colorectal-cancer
#17
Maosong Lin, Bensong Duan, Jiangfeng Hu, Hong Yu, Haihui Sheng, Hengjun Gao, Junxing Huang
Epithelial-mesenchymal transition (EMT) is an early and key process in the metastatic cascade during the progression of colorectal cancer (CRC). The aim of the present study was to identify deregulated EMT-related microRNAs (miRNAs/miRs) of CRC and assess the effect of differentially expressed miRNAs on the prognosis of patients with CRC. Genome-wide expression profiling of miRNAs was assessed in 3 EMT-negative and 3 EMT-positive CRC tissues. Differentially expressed miRNA was further validated in 90 pairs of CRC and corresponding paracarcinoma tissues using the reverse transcription-quantitative polymerase chain reaction (RT-qPCR)...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693229/micrornas-as-outcome-predictors-in-patients-with-metastatic-colorectal-cancer-treated-with-bevacizumab-in-combination-with-folfox
#18
I Kiss, J Mlčochová, K Součková, P Fabian, A Poprach, J Halamkova, M Svoboda, R Vyzula, O Slaby
Bevacizumab is a humanized anti-vascular endothelial growth factor monoclonal antibody, used in combination with a oxaliplatin-based chemotherapy in the treatment of metastatic colorectal cancer (mCRC). The aim of the present study was to identify microRNA (miRNA)-based predictive biomarkers of therapy response in order to avoid unnecessary and costly therapy to non-responding patients. High-throughput miRNA microarray profiling (Affymetrix miRNA array) was performed on a discovery cohort of patients with mCRC...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28690395/an-assessment-of-database-validated-microrna-target-genes-in-normal-colonic-mucosa-implications-for-pathway-analysis
#19
Martha L Slattery, Jennifer S Herrick, John R Stevens, Roger K Wolff, Lila E Mullany
BACKGROUND: Determination of functional pathways regulated by microRNAs (miRNAs), while an essential step in developing therapeutics, is challenging. Some miRNAs have been studied extensively; others have limited information. In this study, we focus on 254 miRNAs previously identified as being associated with colorectal cancer and their database-identified validated target genes. METHODS: We use RNA-Seq data to evaluate messenger RNA (mRNA) expression for 157 subjects who also had miRNA expression data...
2017: Cancer Informatics
https://www.readbyqxmd.com/read/28670764/microrna-375-regulates-proliferation-and-migration-of-colon-cancer-cells-by-suppressing-the-ctgf-egfr-signaling-pathway
#20
Khondoker Jahengir Alam, Ji-Su Mo, Seol-Hee Han, Won-Cheol Park, Hun-Soo Kim, Ki-Jung Yun, Soo-Cheon Chae
MicroRNA 375 (MIR375) is significantly down regulated in human colorectal cancer (CRC) tissues; we have previously identified MIR375 as a colon cancer associated microRNA (miRNA). We identified putative MIR375 target genes by comparing the mRNA microarray analysis data of MIR375-overexpressing cells with the candidate MIR375 target genes predicted by public bioinformatic tools. We investigated that the connective tissue growth factor (CTGF) is a direct target gene of MIR375. Expression of CTGF, a ligand of epidermal growth factor receptor (EGFR), was markedly enhanced in human CRC tissues in comparison with the corresponding normal colon tissues...
July 3, 2017: International Journal of Cancer. Journal International du Cancer
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