Alassane Dicko, Jean-Bosco Ouedraogo, Issaka Zongo, Issaka Sagara, Matthew Cairns, Rakiswendé Serge Yerbanga, Djibrilla Issiaka, Charles Zoungrana, Youssoufa Sidibe, Amadou Tapily, Frédéric Nikièma, Frédéric Sompougdou, Koualy Sanogo, Mahamadou Kaya, Hama Yalcouye, Oumar Mohamed Dicko, Modibo Diarra, Kalifa Diarra, Ismaila Thera, Alassane Haro, Abdoul Aziz Sienou, Seydou Traore, Almahamoudou Mahamar, Amagana Dolo, Irene Kuepfer, Paul Snell, Jane Grant, Jayne Webster, Paul Milligan, Cynthia Lee, Christian Ockenhouse, Opokua Ofori-Anyinam, Halidou Tinto, Abdoulaye Djimde, Daniel Chandramohan, Brian Greenwood
BACKGROUND: Seasonal vaccination with the RTS,S/AS01E vaccine combined with seasonal malaria chemoprevention (SMC) prevented malaria in young children more effectively than either intervention given alone over a 3 year period. The objective of this study was to establish whether the added protection provided by the combination could be sustained for a further 2 years. METHODS: This was a double-blind, individually randomised, controlled, non-inferiority and superiority, phase 3 trial done at two sites: the Bougouni district and neighbouring areas in Mali and Houndé district, Burkina Faso...
August 22, 2023: Lancet Infectious Diseases