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https://www.readbyqxmd.com/read/28214220/comparison-of-the-hanging-drop-technique-and-running-drip-method-for-identifying-the-epidural-space-in-dogs
#1
Fernando Martinez-Taboada, José I Redondo
OBJECTIVE: To compare the running-drip and hanging-drop techniques for locating the epidural space in dogs. STUDY DESIGN: Prospective, randomized, clinical trial. ANIMALS: Forty-five healthy dogs requiring epidural anaesthesia. METHODS: Dogs were randomized into four groups and administered epidural anaesthesia in sternal (S) or lateral (L) recumbency. All blocks were performed by the same person using Tuohy needles with either a fluid-prefilled hub (HDo) or connected to a drip set attached to a fluid bag elevated 60 cm (RDi)...
January 8, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28213975/lab-in-a-tube-real-time-molecular-point-of-care-diagnostics-for-influenza-a-and-b-using-the-cobas%C3%A2-liat%C3%A2-system
#2
Willem Jg Melchers, Judith Kuijpers, Joanna Sickler, Janette Rahamat-Langendoen
BACKGROUND: Rapid diagnosis of influenza A and B is important for direct treatment decisions in patient care and for the reduction of in-hospital transmissions. The new real-time PCR based molecular point-of-care (POC) assay, the cobas(®) Influenza A/B test on the cobas(®) Liat® System (cobas(®) Liat® Influenza A/B assay), generated a PCR result in less than 20 minutes, was evaluated for the detection of influenza A and B. METHOD OF THE STUDY: 121 retrospectively collected respiratory specimens, previously analyzed with a routine influenza A/B test (Diagenode) were tested using the cobas(®) Liat® Influenza A/B assay...
February 18, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28213449/optimal-adenosine-stress-for-maximum-stress-perfusion-coronary-flow-reserve-and-pixel-distribution-of-coronary-flow-capacity-by-kolmogorov-smirnov-analysis
#3
Danai Kitkungvan, Dejian Lai, Hongjian Zhu, Amanda E Roby, Nils P Johnson, Derek D Steptoe, Monica B Patel, Richard Kirkeeide, K Lance Gould
BACKGROUND: Different adenosine stress imaging protocols have not been systemically validated for absolute myocardial perfusion and coronary flow reserve (CFR) by positron emission tomography, where submaximal stress precludes assessing physiological severity of coronary artery disease. METHODS AND RESULTS: In 127 volunteers, serial rest-stress positron emission tomography scans using rubidium-82 with various adenosine infusion protocols identified (1) the protocol with maximum stress perfusion and CFR, (2) test-retest precision in same subject, (3) stress perfusion and CFR after adenosine compared with dipyridamole, (4) heterogeneity of coronary flow capacity combining stress perfusion and CFR, and (5) potential relevance for patients with risk factors or coronary artery disease...
February 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28213343/checking-questionable-entry-of-personally-identifiable-information-encrypted-by-one-way-hash-transformation
#4
Xianlai Chen, Yang C Fann, Matthew McAuliffe, David Vismer, Rong Yang
BACKGROUND: As one of the several effective solutions for personal privacy protection, a global unique identifier (GUID) is linked with hash codes that are generated from combinations of personally identifiable information (PII) by a one-way hash algorithm. On the GUID server, no PII is permitted to be stored, and only GUID and hash codes are allowed. The quality of PII entry is critical to the GUID system. OBJECTIVE: The goal of our study was to explore a method of checking questionable entry of PII in this context without using or sending any portion of PII while registering a subject...
February 17, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/28213342/virtual-visits-for-acute-nonurgent-care-a-claims-analysis-of-episode-level-utilization
#5
Aliza S Gordon, Wallace C Adamson, Andrea R DeVries
BACKGROUND: Expansion of virtual health care-real-time video consultation with a physician via the Internet-will continue as use of mobile devices and patient demand for immediate, convenient access to care grow. OBJECTIVE: The objective of the study is to analyze the care provided and the cost of virtual visits over a 3-week episode compared with in-person visits to retail health clinics (RHC), urgent care centers (UCC), emergency departments (ED), or primary care physicians (PCP) for acute, nonurgent conditions...
February 17, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28213088/personalized-medicine-genetic-risk-prediction-of-drug-response
#6
REVIEW
Ge Zhang, Daniel W Nebert
Pharmacogenomics (PGx), a substantial component of "personalized medicine", seeks to understand each individual's genetic composition to optimize drug therapy -- maximizing beneficial drug response, while minimizing adverse drug reactions (ADRs). Drug responses are highly variable because innumerable factors contribute to ultimate phenotypic outcomes. Recent genome-wide PGx studies have provided some insight into genetic basis of variability in drug response. These can be grouped into three categories. [a] Monogenic (Mendelian) traits include early examples mostly of inherited disorders, and some severe (idiosyncratic) ADRs typically influenced by single rare coding variants...
February 14, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28212968/-what-goes-around-comes-around-lessons-learned-from-economic-evaluations-of-personalized-medicine-applied-to-digital-medicine
#7
Kathryn A Phillips, Michael P Douglas, Julia R Trosman, Deborah A Marshall
BACKGROUND: The growth of "big data" and the emphasis on patient-centered health care have led to the increasing use of two key technologies: personalized medicine and digital medicine. For these technologies to move into mainstream health care and be reimbursed by insurers, it will be essential to have evidence that their benefits provide reasonable value relative to their costs. These technologies, however, have complex characteristics that present challenges to the assessment of their economic value...
January 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28212966/estimating-preferences-for-complex-health-technologies-lessons-learned-and-implications-for-personalized-medicine
#8
Deborah A Marshall, Juan Marcos Gonzalez, Karen V MacDonald, F Reed Johnson
We examine key study design challenges of using stated-preference methods to estimate the value of whole-genome sequencing (WGS) as a specific example of genomic testing. Assessing the value of WGS is complex because WGS provides multiple findings, some of which can be incidental in nature and unrelated to the specific health concerns that motivated the test. In addition, WGS results can include actionable findings (variants considered to be clinically useful and can be acted on), findings for which evidence for best clinical action is not available (variants considered clinically valid but do not meet as high of a standard for clinical usefulness), and findings of unknown significance...
January 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28212873/temperament-and-character-personality-dimensions-in-nitrate-tilt-induced-vasovagal-syncope-patients
#9
Vincenzo Russo, Ahmed AlTurki, Anna Rago, Riccardo Proietti, Guillaume Chaussé, Alessio Maria Monteleone, Pasquale Scognamiglio, Palmiero Monteleone, Gerardo Nigro
INTRODUCTION: Vasovagal syncope (VVS) is a clinical syndrome characterized by transient loss of consciousness and postural tone that is due to a temporary and spontaneously self-terminating global cerebral hypoperfusion. It is known that personality modulates the individual's sensitivity to stressors, and emotional arousal and psychologic uncertainty are conditions contributing to vasodepressor syncope. Therefore it is postulated that personality characteristics of VVS patients could have a role in the pathophysiology of VVS...
February 14, 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/28212391/an-empirical-examination-of-the-factor-structure-of-compassion
#10
Jenny Gu, Kate Cavanagh, Ruth Baer, Clara Strauss
Compassion has long been regarded as a core part of our humanity by contemplative traditions, and in recent years, it has received growing research interest. Following a recent review of existing conceptualisations, compassion has been defined as consisting of the following five elements: 1) recognising suffering, 2) understanding the universality of suffering in human experience, 3) feeling moved by the person suffering and emotionally connecting with their distress, 4) tolerating uncomfortable feelings aroused (e...
2017: PloS One
https://www.readbyqxmd.com/read/28212155/molecular-markers-in-lung-cancer-role-of-ebus
#11
Semra Bilaçeroğlu
PURPOSE OF REVIEW: As demonstrated by the recent therapeutic advances in nonsmall cell lung cancer (NSCLC), a personalized approach can considerably reduce its mortality. RECENT FINDINGS: Molecular tests identifying genetic mutations in NSCLC have led to a shift towards more effective and personalized therapies targeted to these alterations. Adequate tissue is required for diagnosing, subcharacterizing, and genotyping NSCLC by morphological, immunohistochemical, and molecular techniques...
February 16, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/28211886/a-novel-approach-for-the-identification-of-efficient-combination-therapies-in-primary-human-acute-myeloid-leukemia-specimens
#12
I Baccelli, J Krosl, G Boucher, I Boivin, V-P Lavallée, J Hébert, S Lemieux, A Marinier, G Sauvageau
Appropriate culture methods for the interrogation of primary leukemic samples were hitherto lacking and current assays for compound screening are not adapted for large-scale investigation of synergistic combinations. In this study, we report a novel approach that efficiently distills synthetic lethal interactions between small molecules active on primary human acute myeloid leukemia (AML) specimens. In single-dose experiments and under culture conditions preserving leukemia stem cell activity, our strategy considerably reduces the number of tests needed for the identification of promising compound combinations...
February 17, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28211817/post-stroke-acquired-amusia-a-comparison-between-right-and-left-brain-hemispheric-damages
#13
Zahra Jafari, Mahdiye Esmaili, Ahmad Delbari, Masoud Mehrpour, Majid H Mohajerani
BACKGROUND: Although extensive research has been published about the emotional consequences of stroke, most studies have focused on emotional words, speech prosody, voices, or facial expressions. The emotional processing of musical excerpts following stroke has been relatively unexplored. OBJECTIVE: The present study was conducted to investigate the effects of chronic stroke on the recognition of basic emotions in music. METHODS: Seventy persons, including 25 normal controls (NC), 25 persons with right brain damage (RBD) from stroke, and 20 persons with left brain damage (LBD) from stroke between the ages of 31-71 years were studied...
February 15, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28211813/classification-of-depression-cognitive-disorders-and-co-morbid-depression-and-cognitive-disorders-with-perfusion-spect-neuroimaging
#14
Daniel G Amen, Pavitra Krishnamani, Somayeh Meysami, Andrew Newberg, Cyrus A Raji
BACKGROUND: Depression and cognitive disorders (CDs) are two common co-morbid afflictions that commonly present with overlapping symptoms. OBJECTIVE: To evaluate if perfusion neuroimaging with brain SPECT can distinguish persons with depression from those with CDs or both conditions. METHODS: Inclusion criteria were DSM-IV defined depression or CDs (Alzheimer's disease, vascular dementia, dementia not otherwise specified, and amnestic disorders not otherwise specified) including persons with both (total n = 4,541; 847 CDs, 3,269 depression, 425 with both)...
February 10, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28211551/eating-habits-and-the-risk-of-cardiovascular-disease-in-patients-with-recurrent-depressive-disorders
#15
Ewa Stefańska, Agnieszka Wendołowicz, Urszula Cwalina, Beata Konarzewska, Napoleon Waszkiewicz, Lucyna Ostrowska
OBJECTIVES: The aim of the research was to assess the fatty acid content and atherogenicity of daily food rations in patients with recurrent depressive disorders in the aspect of risk of developing cardiovascular disease. METHODS: The study included 126 persons (62 persons with diagnosed recurrent depressive disorders and 64 healthy volunteers). A 24-hour recall was used in the quantitative assessment of the diet. Anthropometric and chemical measurements as well as body composition analysis were used to assess the nutritional status...
December 23, 2016: Psychiatria Polska
https://www.readbyqxmd.com/read/28211483/colonisation-in-social-species-the-importance-of-breeding-experience-for-dispersal-in-overcoming-information-barriers
#16
A Payo-Payo, M Genovart, A Sanz-Aguilar, J L Greño, M García-Tarrasón, A Bertolero, J Piccardo, D Oro
Studying colonisation is crucial to understand metapopulations, evolutionary ecology and species resilience to global change. Unfortunately, few empirical data are available because field monitoring that includes empty patches at large spatiotemporal scales is required. We examine the colonisation dynamics of a long-lived seabird over 34 years in the western Mediterranean by comparing population and individual data from both source colony and the newly-formed colonies. Since social information is not available, we hypothesize that colonisation should follow particular dispersal dynamics and personal information must be crucial in decision making...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28211229/serum-micrornas-as-predictors-for-liver-fibrosis-staging-in-hepatitis-c-virus-associated-chronic-liver-disease-patients
#17
Olfat G Shaker, Mahmoud A Senousy
Accurate staging of liver fibrosis is important for clinical decision making and personalized management. Liver fibrosis is influenced by patients' genomics, including IFNL3 genotype and microRNA expression. However, incorporating microRNAs into fibrosis prediction algorithms has not been investigated. We examined the potential of 8 selected serum microRNAs; miR-122, miR-126, miR-129, miR-199a, miR-155, miR-203a, miR-221, and miR-223 as non-invasive biomarkers to stage liver fibrosis in HCV-associated chronic liver disease (HCV-CLD)...
February 17, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28211026/social-networks-and-health-status-in-the-elderly-the-anziani-in-rete-population-based-study
#18
Luca Bianchetti, Flaminio Squazzoni, Niccolò Casnici, Devis Bianchini, Emirena Garrafa, Claudia Archetti, Valentina Romano, Luca Rozzini, Michele Melchiori, Chiara Fiorentini, Daniela Uberti, Stefano Calza, Alessandra Marengoni
BACKGROUND: Certain features of the social environment could maintain and even improve not only psychological well-being, but also health and cognition of the elderly. AIMS: We tested the association between social network characteristics and the number of chronic diseases in the elderly. METHODS: A randomized sample of the elderly population of Brescia, Italy, was evaluated (N = 200, age ≥65 years). We performed a comprehensive geriatric assessment, including information on socio-demographic variables (family, friendships, and acquaintance contacts)...
February 16, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28210915/determining-childhood-blood-lead-level-screening-compliance-among-physicians
#19
Amanda Haboush-Deloye, Erika R Marquez, Shawn L Gerstenberger
Childhood Lead Poisoning Prevention Programs throughout the U.S. have addressed childhood lead poisoning by implementing primary and secondary prevention efforts. While many programs have helped increase screening rates, in some states children under the age of six still have not been tested for lead. This study aims to identify the barriers to childhood blood lead testing and develop a strategy to increase the number of children tested. Clark County physicians who work with children six and under were surveyed about blood lead level (BLL) testing practices, particularly, adherence to Centers for Disease Control and Prevention (CDC) guidelines, and parental compliance with orders to have their children tested to determine their blood lead levels...
February 16, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28210628/usefulness-of-sweat-management-for-patients-with-adult-atopic-dermatitis-regardless-of-sweat-allergy-a-pilot-study
#20
Sakae Kaneko, Hiroyuki Murota, Susumu Murata, Ichiro Katayama, Eishin Morita
Background. Sweat is an aggravating factor in atopic dermatitis (AD), regardless of age. Sweat allergy may be involved in AD aggravated by sweating. Objective. We investigated whether sweat exacerbates adult AD symptoms and examined the extent of sweat allergy's involvement. Method. We asked 34 AD patients (17 men, 17 women; mean age: 27.8 years) to record the extent to which sweat aggravated their symptoms on a 10-point numerical scale. Participant responses were compared with histamine release tests (HRT)...
2017: BioMed Research International
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