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https://www.readbyqxmd.com/read/29050389/towards-personalized-therapy-for-multiple-sclerosis-prediction-of-individual-treatment-response
#1
Tomas Kalincik, Ali Manouchehrinia, Lukas Sobisek, Vilija Jokubaitis, Tim Spelman, Dana Horakova, Eva Havrdova, Maria Trojano, Guillermo Izquierdo, Alessandra Lugaresi, Marc Girard, Alexandre Prat, Pierre Duquette, Pierre Grammond, Patrizia Sola, Raymond Hupperts, Francois Grand'Maison, Eugenio Pucci, Cavit Boz, Raed Alroughani, Vincent Van Pesch, Jeannette Lechner-Scott, Murat Terzi, Roberto Bergamaschi, Gerardo Iuliano, Franco Granella, Daniele Spitaleri, Vahid Shaygannejad, Celia Oreja-Guevara, Mark Slee, Radek Ampapa, Freek Verheul, Pamela McCombe, Javier Olascoaga, Maria Pia Amato, Steve Vucic, Suzanne Hodgkinson, Cristina Ramo-Tello, Shlomo Flechter, Edgardo Cristiano, Csilla Rozsa, Fraser Moore, Jose Luis Sanchez-Menoyo, Maria Laura Saladino, Michael Barnett, Jan Hillert, Helmut Butzkueven
Timely initiation of effective therapy is crucial for preventing disability in multiple sclerosis; however, treatment response varies greatly among patients. Comprehensive predictive models of individual treatment response are lacking. Our aims were: (i) to develop predictive algorithms for individual treatment response using demographic, clinical and paraclinical predictors in patients with multiple sclerosis; and (ii) to evaluate accuracy, and internal and external validity of these algorithms. This study evaluated 27 demographic, clinical and paraclinical predictors of individual response to seven disease-modifying therapies in MSBase, a large global cohort study...
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29050318/unanticipated-prognosis-of-differential-thyroid-cancer-patients-with-t0-stage-analysis-of-the-seer-database-2004-2013
#2
Chunping Liu, Jie Ming, Wen Zeng, Shuntao Wang, Yiquan Xiong, Qiuyang Zhao, Xingjie Yin, Zeming Liu, Tao Huang
The prognosis of T0 stage differentiated thyroid cancer (DTC) remains unclear. This study aimed to investigate the prognosis of T0 stage DTC patients to provide a new perspective on treatment guidelines for these patients. We investigated a large cohort of DTC patients from the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2013. Patient survival curves were examined by Kaplan-Meier analyses with log-rank tests and Cox proportional hazards regression analyses. In the study cohort, the rate of cancer-specific mortality per 1000 person-years for T0 was higher than T1-T3, but lower than T4...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049852/parental-experiences-of-prenatal-whole-exome-sequencing-wes-in-cases-of-ultrasound-diagnosed-fetal-structural-anomaly
#3
Elizabeth Quinlan-Jones, Sarah C Hillman, Mark D Kilby, Sheila M Greenfield
OBJECTIVE: To explore parental experiences of WES for prenatal diagnosis, and ascertain what influenced their decision-making to undergo testing. METHOD: Twelve women comprised a purposeful sample in a series of semi-structured interviews. All had received a fetal anomaly diagnosis on ultrasound. A topic guide was used, and transcripts were thematically analysed to elicit key themes. RESULTS: Five main themes (parental experiences of prenatal WES, need for information, consent/reasons for prenatal WES, sources of support for prenatal WES, and return of WES findings to families) emerged, some with multiple sub-themes...
October 19, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29049845/impact-of-the-initial-fitness-level-on-the-effects-of-a-structured-exercise-therapy-during-pediatric-stem-cell-transplantation
#4
Susanne Wallek, Anna Senn-Malashonak, Lutz Vogt, Katharina Schmidt, Peter Bader, Winfried Banzer
BACKGROUND: Before and after hematopoietic stem cell transplantation (HSCT), most patients suffer from psychophysical limitations due to the treatment. Exercise interventions demonstrate beneficial effects on, for example, strength, endurance, or health-related quality of life during and after HSCT, but with a great variation among patients concerning the response to exercise. This study examines the influence of the initial fitness on the effects of an exercise therapy in pediatric HSCT...
October 19, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29049282/behavioral-intervention-to-reduce-opioid-overdose-among-high-risk-persons-with-opioid-use-disorder-a-pilot-randomized-controlled-trial
#5
Phillip Oliver Coffin, Glenn-Milo Santos, Tim Matheson, Emily Behar, Chris Rowe, Talia Rubin, Janelle Silvis, Eric Vittinghoff
OBJECTIVE: The United States is amidst an opioid epidemic, including synthetic opioids that may result in rapid death, leaving minimal opportunity for bystander rescue. We pilot tested a behavioral intervention to reduce the occurrence of opioid overdose among opioid dependent persons at high-risk for subsequent overdose. MATERIALS AND METHODS: We conducted a single-blinded randomized-controlled trial of a repeated dose motivational interviewing intervention (REBOOT) to reduce overdose versus treatment as usual, defined as information and referrals, over 16 months at the San Francisco Department of Public Health from 2014-2016...
2017: PloS One
https://www.readbyqxmd.com/read/29049204/the-genetic-association-between-pon1-polymorphisms-and-osteonecrosis-of-femoral-head-a-case-control-study
#6
Jian-Mei Li, Yi Li, Lu Wang
The purpose of this study was to investigate the relationship between Paraoxonase-1 (PON1) gene rs662, rs854555 polymorphisms and osteonecrosis of the femoral head (ONFH) in Han population, northern China.Polymerase chain reaction-restriction fragment length polymorphism was used to determine genotypes of PON1 polymorphisms in 84 patients with ONFH and 96 healthy persons. χ test was used to compare distribution differences of genotype, allele, and haplotype between the case and control groups. The odds ratio (OR) and 95% confidence interval (CI) were calculated to reveal the effects of PON1 polymorphisms on risk of ONFH, and the results were adjusted using logistic regression analysis...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049134/in-trauma-patients-the-occurrence-of-early-onset-nosocomial-infections-is-associated-with-increased-plasma-concentrations-of-chromogranin-a
#7
Francis Schneider, Céline Marban, Gharib Ajob, Sophie Helle, Max Guillot, Anne Launoy, Quentin Maestraggi, Francesco Scavello, Olivier Rohr, Marie-Hélène Metz-Boutigue
In previously healthy persons suffering from acute illnesses, nosocomial infections are frequent. Their prevalence suggests the existence of as yet unknown conditions that may promote care-related infection. This study assessed whether 1) the measurement of plasma chromogranin A, a stress-related protein involved in innate defence, is related to nosocomial infection risk and 2) whether any chromogranin-A-derived fragment included in vasostatin-I displays immunosuppressive activities related to AP-1 or NF-kappa B down regulation...
October 18, 2017: Shock
https://www.readbyqxmd.com/read/29048941/patient-perceptions-of-the-adequacy-of-supplemental-oxygen-therapy-results-of-the-american-thoracic-society-nursing-assembly-oxygen-working-group-survey
#8
Susan S Jacobs, Kathleen O Lindell, Eileen G Collins, Chris M Garvey, Carme Hernandez, Sally McLaughlin, Ann M Schneidman, Paula M Meek
RATIONALE: Pulmonary clinicians and patients anecdotally report barriers to home supplemental oxygen services including inadequate supply, unacceptable portable options, and equipment malfunction. Limited evidence exists to describe or quantify these problems. OBJECTIVE: To describe the frequency and type of problems experienced by supplemental oxygen users in the United States. METHODS: The Patient Supplemental Oxygen Survey, a self-report questionnaire, was posted on the American Thoracic Society (ATS) Public Advisory Roundtable and patient and healthcare-affiliated websites...
October 19, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29048490/a-simple-method-for-the-simultaneous-determination-of-pharmaceuticals-and-personal-care-products-in-river-sediment-by-ultrasound-assisted-extraction-followed-by-solid-phase-microextraction-coupled-with-gas-chromatography-mass-spectrometry
#9
Alejandro Díaz, Araceli Peña-Alvarez
A simple method was developed using ultrasound-assisted extraction (UAE) combined with solid-phase microextraction (SPME) coupled with gas chromatography-mass spectrometry (GC-MS) for the simultaneous determination of eight different pharmaceuticals and personal care products (PPCPs) (ibuprofen, 2-benzyl-4-chlorophenol, naproxen, triclosan, ketoprofen, diclofenac, bisphenol A and estrone) in river sediment. UAE conditions were optimized involving extraction variables such as extraction solvent, extraction time, sample amount, extraction temperature, pH and salt addition...
October 1, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/29048357/health-philosophy-of-dietitians-and-its-implications-for-life-satisfaction-an-exploratory-study
#10
Patricia Grace-Farfaglia, Denise Pickett-Bernard, Andrea White Gorman, Jaleh Dehpahlavan
Studies of health providers suggest that satisfaction with life is related to their values and sense of purpose which is best achieved when their professional role is in harmony with personal philosophy. Cross-sectional surveys suggest that personal health beliefs and practices of health professionals influence their clinical counseling practices. However, little is known about the influence of health philosophy on the personal satisfaction with life for dietitians. This study recruited a randomly selected, cross-sectional sample to complete a self-administered online survey...
October 19, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/29048212/living-too-long-exploring-attitudes-toward-reaching-100-years-old
#11
Oscar Ribeiro, Sofia Canedo, Margarida Cerqueira, Ana Nascimento, Laetitia Teixeira
Objective This study analyses the relationship between pro- and anti-longevity attitudes, attitudes toward centenarians, and the wish to reach 100 years of age in a sample of community dwelling older adults. Methods Participants ( N = 137) completed a questionnaire on attitudes toward life-extension and an aging semantic differential using centenarians as an attitudinal target. Sociodemographic information, perceived health status, and information on knowing a centenarian were also obtained. A cluster analysis was used to identify subgroups (leaning anti-longevity group vs...
January 1, 2017: International Journal of Aging & Human Development
https://www.readbyqxmd.com/read/29047413/itactic-implementing-treatment-algorithms-for-the-correction-of-trauma-induced-coagulopathy-study-protocol-for-a-multicentre-randomised-controlled-trial
#12
Kjersti Baksaas-Aasen, Lewis Gall, Simon Eaglestone, Claire Rourke, Nicole P Juffermans, J Carel Goslings, Paal Aksel Naess, Susan van Dieren, Sisse Rye Ostrowski, Jakob Stensballe, Marc Maegele, Simon J Stanworth, Christine Gaarder, Karim Brohi, Per I Johansson
BACKGROUND: Traumatic injury is the fourth leading cause of death globally. Half of all trauma deaths are due to bleeding and most of these will occur within 6 h of injury. Haemorrhagic shock following injury has been shown to induce a clotting dysfunction within minutes, and this early trauma-induced coagulopathy (TIC) may exacerbate bleeding and is associated with higher mortality and morbidity. In spite of improved resuscitation strategies over the last decade, current transfusion therapy still fails to correct TIC during ongoing haemorrhage and evidence for the optimal management of bleeding trauma patients is lacking...
October 18, 2017: Trials
https://www.readbyqxmd.com/read/29047146/incidence-and-risk-factors-of-colorectal-cancer-based-on-56-324-health-checkups-7-years-retrospective-cohort-study
#13
Toshiko Fujii, Masayuki Ohisa, Toru Sako, Takayuki Harakawa, Kazuaki Sakanume, Shintaro Nagashima, Aya Sugiyama, Yuuichiro Matsuura, Junko Tanaka
BACKGROUND AND AIM: Although mortality rates of colorectal cancer (CRC) have been increasing in Japan, its screening rates remain stagnant at 19.2% among Japanese population aged >40 years in 2014. To evaluate the importance of CRC screening by fecal occult blood test (FOBT), we estimated the incidence of FOBT-positivity and CRC by sex-age stratification and clarified the risk factors for CRC. METHODS: Between 2007 and 2014, 56,324 residents (21,517 men and 34,807 women) were enrolled in this study...
October 19, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29047118/modeling-community-discharge-of-medicaid-nursing-home-residents-implications-for-money-follows-the-person
#14
Zachary Hass, Mark Woodhouse, Robert Kane, Greg Arling
OBJECTIVE: To build and test a model that predicts community discharge probabilities for Medicaid-eligible nursing home (NH) residents who remain in the nursing home at 90 days after admission and, thus, would be candidates for the Money Follows the Person (MFP) program. DATA SOURCE: The Minimum Data Set, Medicaid Management Information Systems, and Minnesota Vital Statistics file. DATA: Cohort of 33, 590 nursing home stays that qualified for Medicaid by the 90th day of their stay from 383 Minnesota nursing homes from July 2011 to June 2013...
October 18, 2017: Health Services Research
https://www.readbyqxmd.com/read/29046952/evaluation-of-a-visual-acuity-test-using-closed-landolt-cs-to-determine-malingering
#15
Nils Kröger, Clemens Jürgens, Thomas Kohlmann, Frank Tost
PURPOSE: To evaluate a visual acuity test (VAT) with unexpected optotypes to detect malingering. METHODS: We tested two groups. Group 1 consisted of 20 individuals with normal best corrected visual acuity (BCVA). Group 2 included participants with ocular diseases and reduced BCVA. All subjects underwent a VAT proposed by Gräf and Roesen to assess suspected malingering. This test used 36 charts with one Landolt-C per page. The first 20 optotypes were Landolt-Cs, while at positions 21, 26, 30, and 34 closed rings were presented...
October 18, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29046494/a-user-centred-design-process-of-new-cold-protective-clothing-for-offshore-petroleum-workers-operating-in-the-barents-sea
#16
Ole Petter Naesgaard, Tore Christian Bjørsvik Storholmen, Øystein Nordrum Wiggen, Jarl Reitan
OBJECTIVE: Petroleum operations in the Barents Sea require personal protective clothing (PPC) to ensure the safety and performance of the workers. This paper describes the accomplishment of a user-centred design process of new PPC for offshore workers operating in this area. METHODS: The user-centred design process was accomplished by mixed-methods. Insights into user needs and context of use were established by group interviews and on-the-job observations during a field-trip...
October 17, 2017: Industrial Health
https://www.readbyqxmd.com/read/29046033/-solar-urticaria-case-report-and-literature-review
#17
María Raigosa, Yuliana Toro, Jorge Sánchez
BACKGROUND: Solar urticaria is a rare type of inducible urticaria characterized by wheal and erythema formation shortly after exposure to sunlight or to an artificial light source; its pathophysiology is not yet entirely understood. The treatment of choice, in addition to exposure avoidance, consists in antihistamine administration. CLINICAL CASE: This is the case of a 27-year-old woman with no personal history of allergic diseases and with a 2-year history of erythema and wheals in photo-exposed areas associated with sunlight exposure for periods longer than 10 minutes...
July 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29045797/public-health-detailing-to-increase-routine-hiv-screening-in-baltimore-maryland-satisfaction-feasibility-and-effectiveness
#18
Amelia Greiner Safi, Jamie Perin, Andrea Mantsios, Christina Schumacher, C Patrick Chaulk, Jacky M Jennings
The objective of this study was to evaluate the satisfaction with, and the feasibility and effectiveness of, a public health detailing project focused on increasing routine human immunodeficiency virus (HIV) screening of people aged 13-64 by primary care providers working in areas of Baltimore City, Maryland, with high rates of HIV transmission (defined as a mean geometric viral load of ≥1500 copies/mL per census tract). In public health detailing, trained public health professionals (ie, detailers) visit medical practice sites to meet with providers and site staff members, with the intention of influencing changes in clinical practice policy and/or behavior...
January 1, 2017: Public Health Reports
https://www.readbyqxmd.com/read/29045645/predictors-of-antimalarial-self-medication-in-illegal-gold-miners-in-french-guiana-a-pathway-towards-artemisinin-resistance
#19
M Douine, Y Lazrek, D Blanchet, S Pelleau, R Chanlin, F Corlin, L Hureau, B Volney, H Hiwat, S Vreden, F Djossou, M Demar, M Nacher, L Musset
Background: Malaria is endemic in French Guiana (FG), South America. Despite the decrease in cases in the local population, illegal gold miners are very affected by malaria (22.3% of them carried Plasmodium spp.). Self-medication seems to be very common, but its modalities and associated factors have not been studied. The aim of this study was to evaluate parasite susceptibility to drugs and to document behaviours that could contribute to resistance selection in illegal gold miners. Methods: This multicentric cross-sectional study was conducted in resting sites along the FG-Surinamese border...
October 17, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29045506/clinical-and-molecular-characterization-of-patients-with-cancers-of-unknown-primary-in-the-modern-era
#20
A M Varghese, A Arora, M Capanu, N Camacho, H H Won, A Zehir, J Gao, D Chakravarty, N Schultz, D S Klimstra, M Ladanyi, D M Hyman, D B Solit, M F Berger, L B Saltz
Background: On the basis of historical data, patients with cancers of unknown primary (CUP) are generally assumed to have a dismal prognosis with overall survival of less than one year. Treatment is typically cytotoxic chemotherapy guided by histologic features and the pattern of metastatic spread. The purpose of this study was to provide a clinical and pathologic description of patients with CUP in the modern era, to define the frequency of clinically actionable molecular alterations in this population, to determine how molecular testing can alter therapeutic decisions, and to investigate novel uses of next generation sequencing in the evaluation and treatment of patients with CUP...
September 26, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
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