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https://www.readbyqxmd.com/read/28738419/posterior-staphylomas-in-pathologic-myopia-imaged-by-widefield-optical-coherence-tomography
#1
Kosei Shinohara, Noriaki Shimada, Muka Moriyama, Takeshi Yoshida, Jost B Jonas, Nagahisa Yoshimura, Kyoko Ohno-Matsui
Purpose: To examine posterior staphylomas by widefield optical coherence tomography (WF-OCT) and three-dimensional magnetic resonance imaging (3D-MRI). Methods: Highly myopic patients (myopic refractive error >8.0 diopters or axial length >26.5 mm) who had previously undergone orbital 3D-MRI were examined by WF-OCT. Results: The study included 100 eyes of 57 patients with a mean age of 67.9 ± 10.7 years (range, 44-85 years) and mean axial length of 30...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28737759/outcome-of-universal-newborn-eye-screening-with-wide-field-digital-retinal-image-acquisition-system-a-pilot-study
#2
P Goyal, T R Padhi, T Das, L Pradhan, S Sutar, S Butola, U C Behera, L Jain, S Jalali
PurposeTo evaluate the outcome of universal newborn eye screening with wide-field digital retinal imaging (WFDRI) system.MethodsIn this pilot study, we examined 1152 apparently healthy newborn infants in the obstetrics and gynecology ward of a civil hospital in Eastern India over 1.5 years. The examination included external eye examination, red reflex test and fundus imaging by WFDRI (RetCam II, Clarity medical system, Pleasanton, CA, USA) by a trained optometrist. The pathologies detected, net monetary gain and skilled manpower saved were documented...
July 24, 2017: Eye
https://www.readbyqxmd.com/read/28737601/new-ways-to-detect-pediatric-sickle-cell-retinopathy-a-comprehensive-review
#3
Daniel A Pahl, Nancy S Green, Monica Bhatia, Royce W S Chen
Sickle retinopathy reflects disease-related vascular injury of the eye, which can potentially result in visual loss from vitreous hemorrhage or retinal detachment. Here we review sickle retinopathy among children with sickle cell disease, describe the epidemiology, pediatric risk factors, pathophysiology, ocular findings, and treatment. Newer, more sensitive ophthalmological imaging modalities are available for retinal imaging, including ultra-widefield fluorescein angiography, spectral-domain optical coherence tomography, and optical coherence tomography angiography...
July 21, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28736474/phenotype-analysis-of-early-risk-factors-from-electronic-medical-records-improves-image-derived-diagnostic-classifiers-for-optic-nerve-pathology
#4
Shikha Chaganti, Kunal P Nabar, Katrina M Nelson, Louise A Mawn, Bennett A Landman
We examine imaging and electronic medical records (EMR) of 588 subjects over five major disease groups that affect optic nerve function. An objective evaluation of the role of imaging and EMR data in diagnosis of these conditions would improve understanding of these diseases and help in early intervention. We developed an automated image-processing pipeline that identifies the orbital structures within the human eyes from computed tomography (CT) scans, calculates structural size, and performs volume measurements...
February 11, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28736470/structural-functional-relationships-between-eye-orbital-imaging-biomarkers-and-clinical-visual-assessments
#5
Xiuya Yao, Shikha Chaganti, Kunal P Nabar, Katrina Nelson, Andrew Plassard, Rob L Harrigan, Louise A Mawn, Bennett A Landman
Eye diseases and visual impairment affect millions of Americans and induce billions of dollars in annual economic burdens. Expounding upon existing knowledge of eye diseases could lead to improved treatment and disease prevention. This research investigated the relationship between structural metrics of the eye orbit and visual function measurements in a cohort of 470 patients from a retrospective study of ophthalmology records for patients (with thyroid eye disease, orbital inflammation, optic nerve edema, glaucoma, intrinsic optic nerve disease), clinical imaging, and visual function assessments...
February 11, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28734946/impaired-rhodopsin-generation-in-the-rat-model-of-diabetic-retinopathy
#6
Volha V Malechka, Gennadiy Moiseyev, Yusuke Takahashi, Younghwa Shin, Jian-Xing Ma
Diabetic retinopathy is a common complication of diabetes mellitus. Diabetic patients experience functional deficits in dark adaptation, contrast sensitivity, and color perception before microvascular pathologies become apparent. Here, we evaluated early changes in neural retinal function and in retinoid metabolism in the eye in diabetes. Streptozotocin-induced diabetic rats showed decreased a-wave and b-wave amplitudes of scotopic and photopic electroretinography responses four months after diabetes induction compared to nondiabetic controls...
July 19, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28734810/retinal-pigment-epithelium-humps-in-high-myopia
#7
Alessandro Marchese, Adriano Carnevali, Riccardo Sacconi, Teresa Centoducati, Lea Querques, Francesco Bandello, Giuseppe Querques
PURPOSE: To report on the presence of retinal pigment epithelium (RPE) humps in high myopia, and to describe the distinctive features from pathological PEDs and choroidal neovascularizations (CNVs). DESIGN: Retrospective cross-sectional study. METHODS: Charts and imaging studies of highly myopic patients presenting between September 2015 and February 2017 at a university teaching hospital were consecutively reviewed. All patients underwent spectral domain optical coherence tomography (OCT)...
July 19, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28732590/cost-utility-of-evaluation-for-posterior-vitreous-detachment-and-prophylaxis-of-retinal-detachment
#8
Nicolas A Yannuzzi, Jonathan S Chang, Gary C Brown, William E Smiddy
PURPOSE: To evaluate the costs and cost-utility of examination for posterior vitreous detachment (PVD) and treatment of associated pathology, and of managing various other peripheral retinal disorders to prevent retinal detachment (RD). DESIGN: A decision analysis model of cost-utility. PARTICIPANTS: There were no participants. METHODS: Published retrospective data on the natural course of PVD, retinal tears, and lattice degeneration were used to quantitate the visual benefits of examination and treatment...
July 18, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28730605/contributions-of-interleukin-33-and-tslp-in-a-papain-soaked-contact-lens-induced-mouse-conjunctival-inflammation-model
#9
Jobu Sugita, Yosuke Asada, Waka Ishida, Satoshi Iwamoto, Katsuko Sudo, Hajime Suto, Toru Matsunaga, Ken Fukuda, Atsuki Fukushima, Norihiko Yokoi, Tatsukuni Ohno, Miyuki Azuma, Nobuyuki Ebihara, Hirohisa Saito, Masato Kubo, Susumu Nakae, Akira Matsuda
INTRODUCTION: Pathological changes of severe chronic allergic conjunctivitis are driven not only via acquired immunity but also via innate immunity. Type 2 immune response-initiating cytokines may play some roles as innate immunity-dependent components of the ocular surface inflammation. To investigate the involvement of type 2 immune response-initiating cytokines in innate immunity-dependent, papain-induced conjunctival inflammation model using IL-25-, IL-33-, and TSLP receptor (TSLPR)-knockout (KO) mice with reference to basophils and ILC2...
July 20, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28730084/analyzing-cytokines-as-biomarkers-to-evaluate-severity-of-glaucoma
#10
Yao Tong, Ya-Li Zhou, Yan Zheng, Manas Biswal, Pei-Quan Zhao, Zhao-Yang Wang
AIM: To analyze cytokines as biomarkers for evaluation of severity of glaucoma. METHODS: This was a prospective case-control study including 29 eyes with glaucoma. Besides, 28 eyes with senile cataract were used as control. Patients were classified into four groups: acute angle closure glaucoma (AACG), chronic angle closure glaucoma (CACG), primary open angle glaucoma (POAG) and senile cataract. Undiluted vitreous samples were collected, then vitreous concentrations of 9 types of cytokines were determined by cytometric bead assay system: γ-interferon (IFNg), interleukin (IL)-10, IL-2, IL-4, IL-5, interferon-γ-inducible protein (IP)-10, monocyte chemoattractant protein (MCP)-1, tumor necrosis factor (TNF)-α, and vascular endothelial growth factor (VEGF)...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28729927/fatigue-and-cognition-pupillary-responses-to-problem-solving-in-early-multiple-sclerosis-patients
#11
Sigrid A de Rodez Benavent, Gro O Nygaard, Hanne F Harbo, Siren Tønnesen, Piotr Sowa, Nils I Landrø, Marte Wendel-Haga, Lars Etholm, Kristian B Nilsen, Liv Drolsum, Emilia Kerty, Elisabeth G Celius, Bruno Laeng
INTRODUCTION: In early multiple sclerosis (MS) patients, cognitive changes and fatigue are frequent and troublesome symptoms, probably related to both structural and functional brain changes. Whether there is a common cause of these symptoms in MS is unknown. In theory, an altered regulation of central neuropeptides can lead to changes in regulation of autonomic function, cognitive difficulties, and fatigue. Direct measurements of central neuropeptides are difficult to perform, but measurements of the eye pupil can be used as a reliable proxy of function...
July 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28729194/establishment-of-human-retinal-mitoscriptome-gene-expression-signature-for-diabetic-retinopathy-using-cadaver-eyes
#12
Gowthaman Govindarajan, Saumi Mathews, Karthik Srinivasan, Kim Ramasamy, Sundaresan Periyasamy
Diabetic retinopathy (DR) is a leading cause of blindness due to retinal microvasculature. We used microarray analysis for the first time to establish the retinal mitoscriptome gene expression signature for DR using human cadaver eyes. Among the 1042 genes, 60 (52-down, 8-up) and 39 (36-down, 3-up) genes were differentially expressed in the DR as compared to normal control and diabetic retinas respectively. These genes were mainly responsible for regulating angiogenesis, anti-oxidant defense mechanism, ATP production and apoptosis contributing to the disease pathology of DR...
July 17, 2017: Mitochondrion
https://www.readbyqxmd.com/read/28728185/novel-presenting-phenotype-in-a-child-with-autosomal-dominant-best-s-vitelliform-macular-dystrophy
#13
Yasmine F Abdalla, Gabriella De Salvo, Ahmad Elsahn, James E Self
Best's macular dystrophy (BMD) usually manifests with visual failure in the first or second decade of life; however, there is a large variability in expressivity of the disease, and some patients have no manifestation other than a pathological electro-oculogram (EOG). Autosomal dominant Best's vitelliform macular dystrophy (AD-BVMD) has a very specific phenotype that varies with the stage of the disease. In recent years, the authors have seen description of another clinical entity known as autosomal recessive BMD...
July 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28726093/the-fluorescence-lifetime-of-lipofuscin-granule-fluorophores-contained-in-the-retinal-pigment-epithelium-cells-from-human-cadaver-eyes-in-normal-state-and-in-the-case-of-visualized-pathology
#14
M A Yakovleva, T B Feldman, P M Arbukhanova, S A Borzenok, V A Kuzmin, M A Ostrovsky
A comparative analysis of fluorescence lifetime of lipofuscin granule fluorophores contained in the retinal pigment epithelium cells from human cadaver eyes in normal state and in the case of visualized pathology was carried out. Measurements of fluorescence lifetimes of bis-retinoids and their photooxidation and photodegradation products were carried out using the method of counting time-correlated photons. Comparative analysis showed that, in the case of visualized pathology, the contribution of photooxidation and photodegradation products of bis-retinoids to the total fluorescence of the retinal pigment epithelium cell suspension increases in comparison with the norm...
May 2017: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28725485/segmentation-errors-in-macular-ganglion-cell-analysis-as-determined-by-optical-coherence-tomography-in-eyes-with-macular-pathology
#15
Rayan A Alshareef, Abhilash Goud, Mikel Mikhail, Hady Saheb, Hari Kumar Peguda, Sunila Dumpala, Shruthi Rapole, Jay Chhablani
BACKGROUND: To evaluate artifacts in macular ganglion cell inner plexiform layer (GCIPL) thickness measurement in eyes with retinal pathology using spectral-domain optical coherence tomography (SD OCT). METHODS: Retrospective analysis of color-coded maps, infrared images and 128 horizontal B-scans (acquired in the macular ganglion cell inner plexiform layer scans), using the Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA). The study population included 105 eyes with various macular conditions compared to 30 eyes of 30 age-matched healthy volunteers...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28724829/case-report-of-a-secondary-macular-hole-closure-after-intravitreal-bevacizumab-therapy-in-a-patient-with-retinal-pigment-epithelial-detachment
#16
Marcus Werner Storch, Hans Hoerauf
We describe a case of macular hole (MH) closure after intravitreal bevacizumab therapy for an underlying pigment epithelial detachment (PED) due to exudative age-related macular degeneration (AMD). The 73-year-old Caucasian female presented with reduced visual acuity (20/80) of the left eye and metamorphopsia for approximately 6 months. Spectral domain optical coherence tomography revealed a subfoveal PED due to AMD with an associated MH. To treat the exudative component of the pathology, we started intravitreal bevacizumab therapy, consecutively leading to reduction of the height of PED and allowing closure of the MH...
July 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28722532/bi-institutional-retrospective-study-on-the-demographics-and-basic-clinical-presentation-of-hidrocystomas
#17
Michelle Maeng, Paul Petrakos, Mei Zhou, Benjamin Levine, Gary Lelli, Pete Setabutr
Hidrocystomas are benign, cystic lesions of eccrine and apocrine sweat glands. The literature on hidrocystomas is sparse, consisting of a handful of case reports and limited retrospective reviews. This is the first known bi-institutional, retrospective, chart review aimed to elucidate the demographics and basic clinical presentation of hidrocystomas. Medical records of adult patients with a pathological diagnosis of hidrocystoma from September 1, 2008 to August 1, 2015 in the Oculoplastic and Reconstructive Surgery Service at the Illinois Eye and Ear Infirmary (UIC) and Department of Ophthalmology of Weill Cornell Medical College (Cornell) were reviewed...
July 19, 2017: Orbit
https://www.readbyqxmd.com/read/28721008/effect-of-age-sex-and-refractive-errors-on-central-corneal-thickness-measured-by-oculus-pentacam-%C3%A2
#18
Nauman Hashmani, Sharif Hashmani, Azfar N Hanfi, Misbah Ayub, Choudhry M Saad, Hina Rajani, Marium G Muhammad, Misbahul Aziz
BACKGROUND: Central corneal thickness (CCT) can be used to assess the corneal physiological condition as well as the pathological changes associated with ocular diseases. It has an influence on the measurement of intraocular pressure and is being used as a screening tool for refractive surgery candidates. The aim of this study was to determine the median CCT among normal Pakistani population and to correlate CCT with age, sex, and refractive errors. METHODS: We conducted a retrospective analysis of 5,171 healthy eyes in 2,598 patients who came to Hashmanis Hospital, Karachi, Pakistan...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28720436/direct-measurement-of-pressure-independent-aqueous-humour-flow-using-iperfusion
#19
Michael Madekurozwa, Ester Reina-Torres, Darryl R Overby, Joseph M Sherwood
Reduction of intraocular pressure is the sole therapeutic target for glaucoma. Intraocular pressure is determined by the dynamics of aqueous humour secretion and outflow, which comprise several pressure-dependent and pressure-independent mechanisms. Accurately quantifying the components of aqueous humour dynamics is essential in understanding the pathology of glaucoma and the development of new treatments. To better characterise aqueous humour dynamics, we propose a method to directly measure pressure-independent aqueous humour flow...
July 15, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28717520/modeling-chronic-dacryocystitis-in-rabbits-by-nasolacrimal-duct-obstruction-with-self-curing-resin
#20
Kai Hou, Tao Ai, Rong Liu, Nan Xiang, Jing Jin, Weikun Hu, Ban Luo
We established a chronic dacryocystitis model by injecting of 0.05, 0.1, and 0.15 ml self-curing resin via the lacrimal punctum in rabbits. Animals were randomized into four groups (n = 11 animals/group). The control group received 0.15 ml normal saline. Within three months postinjection, epiphora and eye discharge were observed. At the 90th day postlacrimal passage irrigation, CT dacryocystography was performed to find changes in the lacrimal image, and hematoxylin and eosin staining was made to identify pathological changes of the lacrimal sac...
2017: Journal of Ophthalmology
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