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https://www.readbyqxmd.com/read/28329421/naproxen-inhibits-uvb-induced-basal-cell-and-squamous-cell-carcinoma-development-in-ptch1-skh-1-hairless-mice
#1
Sandeep C Chaudhary, Mohammad Waseem, Mehtab Rana, Hui Xu, Levy Kopelovich, Craig A Elmets, Mohammad Athar
Naproxen possesses anti-proliferative and pro-apoptotic effects besides its known anti-inflammatory functions. Here, we demonstrate the anti-cancer effects of naproxen against UVB-induced BCCs and SCCs in a highly susceptible murine model of UVB carcinogenesis. Naproxen significantly inhibited UVB-induced BCCs and SCCs in this model. Tumor number and volume were significantly decreased (p<0.005 and p<0.05, respectively). Inhibition in UVB-induced SCCs and BCCs was 77% and 86%, respectively, which was associated with reduced PCNA and cyclin D1 and increased apoptosis...
March 22, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28329021/comparison-of-anti-inflammatory-activities-of-an-anthocyanin-rich-fraction-from-portuguese-blueberries-vaccinium-corymbosum-l-and-5-aminosalicylic-acid-in-a-tnbs-induced-colitis-rat-model
#2
Sónia R Pereira, Rita Pereira, Isabel Figueiredo, Victor Freitas, Teresa C P Dinis, Leonor M Almeida
Despite the actual therapeutic approaches for inflammatory bowel disease (IBD), efficient and secure alternative options remain a research focus. In this context, anthocyanins seem promising natural anti-inflammatory agents, but their action mechanisms and efficacy as compared with established drugs still require more clarification. The main aim of this study was to compare the anti-inflammatory action of a chemically characterized anthocyanin-rich fraction (ARF), obtained from Portuguese blueberries (Vaccinium corymbosum L...
2017: PloS One
https://www.readbyqxmd.com/read/28328190/effects-of-nitric-oxide-inhibitors-in-mice-with-bladder-outlet-obstruction
#3
Marcy Lancia Pereira, Carlos Arturo Levi D'ancona, Julio Alejandro Rojas-Moscoso, Antonio Celso Saragossa Ramos, Fabiola Zakia Monica, Edson Antunes
PURPOSE: To investigate the lower urinary tract changes in mice treated with L-NAME, a non-selective competitive inhibitor of nitric oxide synthase (NOS), or aminoguanidine, a competitive inhibitor of inducible nitric oxide synthase (iNOS), after 5 weeks of partial bladder outlet obstruction (BOO), in order to evaluate the role of constitutive and non-constitutive NOS in the pathogenesis of this experimental condition. MATERIALS AND METHODS: C57BL6 male mice were partially obstructed and randomly allocated into 6 groups: Sham, Sham + L-NAME, Sham + aminoguanidine, BOO, BOO + L-NAME and BOO + aminoguanidine...
March 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28327412/response-of-inos-and-its-relationship-with-il-22-and-stat3-in-macrophage-activity-in-the-polar-forms-of-leprosy
#4
Jorge Rodrigues de Sousa, Raphael Primo Martins de Sousa, Tinara Leila de Souza Aarão, Leonidas Braga Dias, Francisca Regina Oliveira Carneiro, Juarez Antonio Simões Quaresma
Leprosy is a chronic granulomatous infection that manifests as different clinical forms related to the immunological response. The aim of the study was to evaluated the response of IL-22, STAT3, CD68 and iNOS in leprosy skin lesions. The mean number IL-22 positive cells was 12.12±1.90 cells/field in the TT form and 31.31±2.91 cells/field in the LL form. STAT3 positive cells was 5.29±1.96 cells/field in the TT form, while this number was 11.13±3.48 cells/field in the LL form. The mean number of CD68 positive cells was 25...
March 18, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28326455/neutralization-of-mmp-2-and-tnfr1-regulates-the-severity-of-s-aureus-induced-septic-arthritis-by-differential-alteration-of-local-and-systemic-proinflammatory-cytokines-in-mice
#5
Sahin Sultana, Rana Adhikary, Biswadev Bishayi
Despite advancement in the field of antibiotics septic arthritis remains a serious concern till date. Staphylococcus aureus is the most common bacterium that causes septic arthritis. Severity of this disease is directly correlated with chronic inflammation induced by proinflammatory cytokines like TNF-α, interleukin (IL)-1β, IL-6, and induction of matrix metalloproteinases (MMPs) including MMP-2. The objective of our study was to evaluate the role of MMP-2 and tumor necrosis factor receptor 1 (TNFR1) in the pathogenesis of S...
March 22, 2017: Inflammation
https://www.readbyqxmd.com/read/28325930/%C3%AE-ionylidene-type-sesquiterpenoids-possessing-antimicrobial-activity-against-porphyromonas-gingivalis-from-phellinus-linteus-and-their-absolute-structure-determination
#6
Tatsuya Shirahata, Chieko Ino, Fumi Mizuno, Yoshihisa Asada, Masao Hirotani, George A Petersson, Satoshi Ōmura, Takafumi Yoshikawa, Yoshinori Kobayashi
No abstract text is available yet for this article.
March 22, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28325756/a-novel-role-for-myeloid-cell-specific-neuropilin-1-in-mitigating-sepsis
#7
Xiaoyan Dai, Imoh Okon, Zhaoyu Liu, Yue Wu, Huaiping Zhu, Ping Song, Ming-Hui Zou
Sepsis-typically caused by an uncontrolled and amplified host systemic inflammatory response to microbial infection-is a life-threatening complex clinical disorder and remains a major cause of infection-related deaths in the intensive care unit. Emerging evidence suggests that neuropilin 1 (Nrp1), an originally defined coreceptor for class 3 semaphorins and VEGF, plays important roles in the immune system; however, the function and regulation of macrophage Nrp1 in host immune defense against bacterial infection remain unknown...
March 21, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28325363/the-role-and-prognostic-value-of-inducible-nitric-oxide-synthase-inos-and-interleukin-33-il-33-in-serous-and-mucinous-epithelial-ovarian-tumours
#8
Eman M Saied, Nour M El-Etreby
Understanding different mechanisms contributing to the aggressive behaviour of epithelial ovarian cancer (EOC) is a large challenge. Interaction between inflammation, immunity and carcinogenesis occurs in different cancers; however, the potential roles of different molecules involved in these processes in relation to ovarian carcinogenesis were not fully investigated. Inducible nitric oxide synthase (iNOS) and interleukin-33 (IL-33) are implicated in carcinogenesis. iNOS is an NOS isoform that generates nitric oxide, which plays important roles in various stages of carcinogenesis...
April 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28325291/systemic-rala-inos-nanoparticles-a-potent-gene-therapy-for-metastatic-breast-cancer-coupled-as-a-biomarker-of-treatment
#9
Cian M McCrudden, John W McBride, Joanne McCaffrey, Ahlam A Ali, Nicholas J Dunne, Vicky L Kett, Jonathan A Coulter, Tracy Robson, Helen O McCarthy
This study aimed to determine the therapeutic benefit of a nanoparticular formulation for the delivery of inducible nitric oxide synthase (iNOS) gene therapy in a model of breast cancer metastasis. Nanoparticles comprising a cationic peptide vector, RALA, and plasmid DNA were formulated and characterized using a range of physiochemical analyses. Nanoparticles complexed using iNOS plasmids and RALA approximated 60 nm in diameter with a charge of 25 mV. A vector neutralization assay, performed to determine the immunogenicity of nanoparticles in immunocompetent C57BL/6 mice, revealed that no vector neutralization was evident...
March 17, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28322935/early-pathogenesis-during-infectious-bursal-disease-in-susceptible-chickens-is-associated-with-changes-in-b-cell-genomic-methylation-and-loss-of-genome-integrity
#10
Nick A Ciccone, Lorraine P Smith, William Mwangi, Amy Boyd, Andrew J Broadbent, Adrian L Smith, Venugopal Nair
We propose a model by which an increase in the genomic modification, 5-hydroxymethylcytosine (5hmC), contributes to B cell death within the chicken bursa of Fabricus (BF) infected with infectious bursal disease virus (IBDV). Our findings indicate that, following an IBDV infection, Rhode Island Red (RIR) chickens have fewer surviving B cells and higher levels of 5hmC in the BF than the more resistant 15l line of birds. Elevated genomic 5hmC levels within the RIR BF are associated with markers of immune responses: infiltrating T cells and increased expression of CD40L, FasL and iNOS...
March 17, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28322346/resveratrol-mitigates-lipopolysaccharide-mediated-acute-inflammation-in-rats-by-inhibiting-the-tlr4-nf-%C3%AE%C2%BAbp65-mapks-signaling-cascade
#11
Guangxi Wang, Zhiqiang Hu, Qiuting Fu, Xu Song, Qiankun Cui, Renyong Jia, Yuanfeng Zou, Changliang He, Lixia Li, Zhongqiong Yin
Resveratrol (RSV) is a natural compound exhibiting anti-inflammatory effect, but the anti-inflammatory mechanism has not been fully understood. This study is aimed to evaluate the anti-inflammatory activity and mechanism of RSV in lipopolysaccharides-induced rats' model. The visceral wet/dry weight ratios and the changes of hematologic and biochemical indices indicated that LPS- stimulation mainly caused damages to liver and lung, while pretreatment with RSV could alleviate the lesions. The cytokine assays showed that RSV could markedly decrease the production of proinflammatory mediators and cytokines (IL-1, IL-1β, IL-6, NO, iNOS and COX-2), and increase the expression of anti-inflammatory mediator (IL-10)...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28322323/anti-inflammatory-properties-of-shikonin-contribute-to-improved-early-stage-diabetic-retinopathy
#12
Po-Lin Liao, Cheng-Hui Lin, Ching-Hao Li, Chi-Hao Tsai, Jau-Der Ho, George C Y Chiou, Jaw-Jou Kang, Yu-Wen Cheng
Diabetic retinopathy (DR), a major microvascular complication of diabetes, leads to retinal vascular leakage, neuronal dysfunction, and apoptosis within the retina. In this study, we combined STZ with whole-body hypoxia (10% O2) for quicker induction of early-stage retinopathy in C57BL/6 mice. We also compared the effects of a high glucose condition combined with hypoxia (1% O2) to a low glucose condition by using retinal pigment epithelial (RPE) cells, which are a crucial component of the outer blood-retinal barrier and the damage is related to retinopathy...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28321075/management-of-pulmonary-mucormycosis-based-on-a-polymerase-chain-reaction-pcr-diagnosis-in-patients-with-hematologic-malignancies-a-report-of-four-cases
#13
Kazuko Ino, Kazunori Nakase, Akiko Nakamura, Yoshiki Nakamori, Yumiko Sugawara, Kana Miyazaki, Fumihiko Monma, Atsushi Fujieda, Yuka Sugimoto, Kohshi Ohishi, Masahiro Masuya, Naoyuki Katayama
Pulmonary mucormycosis (PM) is a life-threatening fungal infection in patients with hematologic malignancies, and early and accurate diagnostic modalities are urgently needed. We conducted a polymerase chain reaction (PCR) assay targeting these fungi in peripheral blood from four patients with hematologic malignancies who were strongly suspected of having PM. In these four patients, the Rhizopus species was identified in two patients, and the Cunninghamella and Absidia species in one each. Based on these molecular findings, all of the patients were successfully treated via targeted therapy with liposomal amphotericin B...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28320722/in-vitro-and-in-vivo-antibacterial-activities-of-patchouli-alcohol-a-natural-occurring-tricyclic-sesquiterpene-against-helicobacter-pylori-infection
#14
Y F Xu, D W Lian, Y Q Chen, Y F Cai, Y F Zheng, P L Fan, W K Ren, L J Fu, Y C Li, J H Xie, H Y Cao, B Tan, Z R Su, P Huang
This study further evaluated the in vitro and in vivo anti-Helicobacter pylori activity and potential underlying mechanism of patchouli alcohol (PA), a tricyclic sesquiterpene. In in vitro assay, the capacities of PA to inhibit and kill H. pylori were tested on three standard strains at different pH values and 12 clinical isolates. The effects of PA on H. pylori adhesion (and its alpA, alpB and babA genes), motility (and its flaA and flaB genes), ultrastructure and flagellation were investigated. Moreover, the H...
March 20, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28320709/plasmin-and-plasminogen-induce-macrophage-reprogramming-and-regulate-key-steps-of-inflammation-resolution-via-annexin-a1
#15
Michelle A Sugimoto, Ana Luíza C Ribeiro, Bruno R C Costa, Juliana P Vago, Kátia M Lima, Fernanda S Carneiro, Mylena Maira O Ortiz, Graziele Letícia N Lima, Aline A F Carmo, Renata M Rocha, Denise A Perez, Alessandra C Reis, Vanessa Pinho, Lindsey A Miles, Cristiana C Garcia, Mauro M Teixeira, Lirlândia P Sousa
Inflammation resolution is an active process that functions to restore tissue homeostasis. Participation of the plasminogen/plasmin (Plg/Pla) system in the productive phase of inflammation is well known, but its involvement in the resolution phase remains unclear. Therefore, we aimed to investigate the potential role of Plg/Pla in key events during the resolution of acute inflammation and its underlying mechanisms. Plg/Pla injection into the pleural cavity of BALB/c mice induced a time-dependent influx of mononuclear cells that were primarily macrophages of anti-inflammatory (M2 - F4/80(high) Gr1(-) CD11b(high)) and proresolving (Mres - F4/80(med) CD11b(low)) phenotypes, without changing the number of macrophages with a pro-inflammatory profile (M1 - F4/80(low) Gr1(+) CD11b(med))...
March 20, 2017: Blood
https://www.readbyqxmd.com/read/28320516/l-f001-a-novel-multifunctional-rock-inhibitor-suppresses-neuroinflammation-in-vitro-and-in-vivo-involvement-of-nf-%C3%AE%C2%BAb-inhibition-and-nrf2-pathway-activation
#16
Jingkao Chen, Wei Yin, Yalin Tu, Shengnan Wang, Xiaohong Yang, Qiuhe Chen, Xiao Zhang, Yifan Han, Rongbiao Pi
Microglia and astrocytes are largely responsible for inflammatory injury in the brain of Alzheimer's disease (AD). Increasing evidence has indicated that Rho kinase (ROCK) plays an important role in the regulation of neuroinflammation. Previously, we synthesized a new chemical entity L-F001 and proved its potential inhibitory effects on ROCK and oxidative stress. Here, we investigated the anti-inflammatory effects and the molecular mechanisms of L-F001 in vitro and in vivo. L-F001 remarkably suppressed lipopolysaccharides (LPS)-elevated expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) as well as LPS-induced production of nitric oxide (NO), reactive oxygen species, interleukin-6 (IL-6) and tumor necreactive oxygen speciesis factor-α (TNF-α) in microglial BV-2 cells and in cultured astrocytes...
March 16, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28319651/mediterranean-tomato-based-sofrito-protects-against-vascular-alterations-in-obese-zucker-rats-by-preserving-no-bioavailability
#17
Rosalia Rodriguez-Rodriguez, Francesc Jiménez-Altayó, Laia Alsina, Yara Onetti, Jose F de Alvarenga, Carmen Claro, Elena Ogalla, Nuria Casals, Rosa M Lamuela-Raventos
SCOPE: Sofrito, a key component of the Mediterranean diet, provides nutritional interest due to its high content in bioactive compounds from tomato and olive oil, and especially to the lipid matrix in which these compounds are found. In this study, the potential beneficial effects of dietary intake of sofrito on obesity-related vascular alterations were explored in obese Zucker rats. METHODS AND RESULTS: Obese and lean rats were fed a control diet supplemented or not with 2% (w/w) sofrito for 8 weeks...
March 20, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28317731/encapsulation-of-sesamol-in-phosphatidyl-choline-micelles-enhanced-bioavailability-and-anti-inflammatory-activity
#18
P S Yashaswini, Nawneet K Kurrey, Sridevi A Singh
Sesamol, the phenolic degradation product of sesamolin, although recognised for its anti-inflammatory effects, has low bioavailability. In this manuscript, we attempted to improve its bioavailability by encapsulation in mixed phosphatidylcholine micelles. Sesamol could be solubilised and entrapped in phosphatidylcholine mixed micelles (PCS) with 96.8% efficiency (particle size 3.0±0.06nm). Fluorescence spectra of PCS revealed lower relative fluorescence intensity (RFI 112) compared to 'free' sesamol (FS) (RFI 271)...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28316375/torilin-inhibits-inflammation-by-limiting-tak1-mediated-map-kinase-and-nf-%C3%AE%C2%BAb-activation
#19
Mehari Endale, Tae-Hwan Kim, Yi-Seong Kwak, Na-Mi Kim, Seung-Hyung Kim, Jae Youl Cho, Bong-Sik Yun, Man-Hee Rhee
Torilin, a sesquiterpene isolated from the fruits of Torilis japonica, has shown antimicrobial, anticancer, and anti-inflammatory properties. However, data on the mechanism of torilin action against inflammation is limited. This study aimed at determining the anti-inflammatory property of torilin in LPS-induced inflammation using in vitro model of inflammation. We examined torilin's effect on expression levels of inflammatory mediators and cytokines in LPS-stimulated RAW 264.7 macrophages. The involvement of NF-kB and AP-1, MAP kinases, and adaptor proteins were assessed...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28315683/klotho-ameliorates-cyclosporine-a-induced-nephropathy-via-pdlim2-nf-kb-p65-signaling-pathway
#20
Meihua Jin, Pengfei Lv, Guanyu Chen, Peng Wang, Zhongfu Zuo, Lili Ren, Jing Bi, Chul-Woo Yang, Xifan Mei, Donghe Han
Klotho, an antiaging protein, can extend the lifespan and modulate cellular responses to inflammation and oxidative stress which can ameliorate chronic kidney diseases (CKD). To investigate the molecular mechanism of Klotho on inflammation in cyclosporine A (CsA) induced nephropathy, the mice were transfected with adenovirus mediated Klotho gene and treated with cyclosporine A (CsA; 30 mg/kg/day) for 4 weeks. Also, primary human renal proximal tubule epithelial cells (RPTECs) were treated with soluble Klotho protein and LPS...
March 15, 2017: Biochemical and Biophysical Research Communications
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