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https://www.readbyqxmd.com/read/28331130/cytopenias-and-clonal-expansion-of-gamma-delta-t-cells-in-a-patient-with-anaplasmosis-a-potential-diagnostic-pitfall
#1
Daniel Marko, Anamarija M Perry, Arjuna Ponnampalam, Michel R Nasr
Human granulocytic anaplasmosis is a rare, tick-borne infectious disease caused by Anaplasma phagocytophilum. Herein, we report a rare case of human granulocytic anaplasmosis associated with cytopenias and clonal expansion of gamma/delta T-cells in the bone marrow. A 77-year old man presented multiple times to the emergency department complaining of muscle weakness. Complete blood count detected cytopenias and peripheral blood smear showed pseudo Pelger-Huet neutrophils. These findings prompted bone marrow evaluation with ancillary studies including flow cytometry, karyotyping and T-cell rearrangement studies...
2017: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/28327690/kyasanur-forest-disease-kfd-rare-disease-of-zoonotic-origin
#2
M Muraleedharan
Kyasanur forest disease (KFD) is a rare tick borne zoonotic disease that causes acute febrile hemorrhagic illness in humans and monkeys especially in southern part of India. The disease is caused by highly pathogenic KFD virus (KFDV) which belongs to member of the genus Flavivirus and family Flaviviridae. The disease is transmitted to monkeys and humans by infective tick Haemaphysalisspinigera. Seasonal outbreaks are expected to occur during the months of January to June. The aim of this paper is to briefly summarize the epidemiology, mode of transmission of KFD virus, clinical findings, diagnosis, treatment, control and prevention of the disease...
September 2016: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/28322187/influence-of-genetic-background-on-hematologic-and-histopathologic-alterations-during-acute-granulocytic-anaplasmosis-in-129-svev-and-c57bl-6j-mice-lacking-type-i-and-type-ii-interferon-signaling
#3
Jennifer L Johns Marielle L Discipulo Amanda L Koehne Kaitlin A Moorhead And Claude M Nagamine
The role of host type I IFN signaling and its interaction with other immune pathways during bacterial infections is incompletelyunderstood. Type II IFN signaling plays a key role during numerous bacterial infections including granulocytic anaplasmosis (GA)caused by Anaplasma phagocytophilum infection. The function of combined type I and type II IFN signaling and their potentialsynergism during GA and similar tick-borne diseases is a topic of current research investigation. The goal of this study was toevaluate 2 mouse models of absent type I/type II IFN signaling in experimental A...
March 20, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28316419/comparison-between-conventional-and-molecular-methods-for-diagnosis-of-bovine-babesiosis-babesia-bovis-infection-in-tick-infested-cattle-in-upper-egypt
#4
Amira A T Al-Hosary
Ticks and tick-borne diseases are the main problems affecting the livestock production in Egypt. Bovine babesiosis has adverse effects on the animal health and production. A comparison of Giemsa stained blood smears, polymerase chain reaction (PCR) and nested PCR (nPCR) assays for detection of Babesia bovis infection in Egyptian Baladi cattle (Bos taurus) in reference to reverse line blot was carried out. The sensitivity of PCR and nested PCR (nPCR) assays were 65 and 100 % respectively. Giemsa stained blood smears showed the lowest sensitivity (30 %)...
March 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28316015/expression-and-characterization-of-codon-optimized-crimean-congo-hemorrhagic-fever-virus-gn-glycoprotein-in-insect-cells
#5
Mehdi Rahpeyma, Alireza Samarbaf-Zadeh, Manoochehr Makvandi, Ata A Ghadiri, Stuart D Dowall, Fatemeh Fotouhi
Crimean-Congo hemorrhagic fever virus (CCHFV) is a major cause of tick-borne viral hemorrhagic disease in the world. Despite of its importance as a deadly pathogen, there is currently no licensed vaccine against CCHF disease. The attachment glycoprotein of CCHFV (Gn) is a potentially important target for protective antiviral immune responses. To characterize the expression of recombinant CCHFV Gn in an insect-cell-based system, we developed a gene expression system expressing the full-length coding sequence under a polyhedron promoter in Sf9 cells using recombinant baculovirus...
March 18, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28303129/there-is-a-method-to-the-madness-strategies-to-study-host-complement-evasion-by-lyme-disease-and-relapsing-fever-spirochetes
#6
REVIEW
Ashley L Marcinkiewicz, Peter Kraiczy, Yi-Pin Lin
Lyme disease and relapsing fever are caused by various Borrelia species. Lyme disease borreliae, the most common vector-borne pathogens in both the U.S. and Europe, are transmitted by Ixodes ticks and disseminate from the site of tick bites to tissues leading to erythema migrans skin rash, arthritis, carditis, and neuroborreliosis. Relapsing fever borreliae, carried by ticks and lice, trigger reoccurring fever episodes. Following transmission, spirochetes survive in the blood to induce bacteremia at the early stages of infection, which is thought to promote evasion of the host complement system...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28298245/serological-and-molecular-prevalence-of-canine-vector-borne-diseases-cvbds-in-korea
#7
Guk-Hyun Suh, Kyu-Sung Ahn, Jong-Ho Ahn, Ha-Jung Kim, Christian Leutenegger, SungShik Shin
BACKGROUND: Previous surveys in dogs from Korea indicated that dogs are exposed to a variety of vector- borne pathogens, but perception for a nation-wide canine vector-borne disease (CVBD) occurrence has been missing. We report here results of both serological and molecular prevalence studies for major CVBDs of dogs from all over the South Korean Peninsula except for Jeju Island. RESULTS: Serological survey of 532 outdoor dogs revealed the highest prevalence for Dirofilaria immitis (25...
March 16, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28291638/lyme-disease-emergency-department-considerations
#8
Nathan D Applegren, Chadd K Kraus
BACKGROUND: Lyme disease (LD) is the most common vector-borne illness in North America. Reported cases of LD have increased from approximately 10,000 cases annually in 1991 to >25,000 cases in 2014. Greater recognition, enhanced surveillance, and public education have contributed to the increased prevalence, as have geographic expansion and the number of infected ticks. Cases are reported primarily in the Northeastern United States, Wisconsin, and Minnesota, with children having the highest incidence of LD among all age groups...
March 10, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28288759/feline-and-canine-leishmaniosis-and-other-vector-borne-diseases-in-the-aeolian-islands-pathogen-and-vector-circulation-in-a-confined-environment
#9
Domenico Otranto, Ettore Napoli, Maria Stefania Latrofa, Giada Annoscia, Viviana Domenica Tarallo, Grazia Greco, Eleonora Lorusso, Laura Gulotta, Luigi Falsone, Fabrizio Solari Basano, Maria Grazia Pennisi, Katrin Deuster, Gioia Capelli, Filipe Dantas-Torres, Emanuele Brianti
Vector-borne diseases (VBDs) are prevalently investigated in dogs. Studies on feline VBDs are scant, though feline leishmaniosis (FeL) is increasingly recognised as a disease of cats in endemic areas. Comprehensive investigations on the distribution of VBDs in populations of cats and dogs living in relatively small geographical areas, such as islands, are currently lacking. In this study the prevalence of Leishmania infantum and other VBD pathogens was assessed in cohorts of cats and dogs living in the Aeolian Islands...
March 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28285590/molecular-detection-of-hepatozoon-spp-and-cytauxzoon-sp-in-domestic-and-stray-cats-from-madrid-spain
#10
David Díaz-Regañón, Alejandra Villaescusa, Tania Ayllón, Fernando Rodríguez-Franco, Gad Baneth, Lydia Calleja-Bueno, Mercedes García-Sancho, Beatriz Agulla, Ángel Sainz
BACKGROUND: Different species of apicomplexan protozoans of the genera Hepatozoon and Cytauxzoon can infect domestic cats, but their epidemiology and clinical relevance are not fully understood. The aim of this study was to assess the molecular prevalence of Hepatozoon spp. and Cytauxzoon spp. and to identify associated risk factors and clinical and laboratory abnormalities in a population of cats from Madrid, Spain. METHODS: Six hundred and forty-four client-owned and stray cats from Madrid, Spain, were included in this study...
March 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28285585/searching-for-lyme-borreliosis-in-australia-results-of-a-canine-sentinel-study
#11
Peter J Irwin, Ian D Robertson, Mark E Westman, Martine Perkins, Reinhard K Straubinger
BACKGROUND: Lyme borreliosis is a common tick-borne disease of the northern hemisphere that is caused by bacterial spirochaetes of the Borrelia burgdorferi (sensu lato) (Bbsl) complex. To date, there has been no convincing evidence for locally-acquired Lyme borreliosis on the Australian continent and there is currently a national debate concerning the nature and distributions of zoonotic tick-transmitted infectious disease in Australia. In studies conducted in Europe and the United States, dogs have been used as sentinels for tick-associated illness in people since they readily contact ticks that may harbour zoonotic pathogens...
March 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28284610/association-of-ehrlichia-canis-hemotropic-mycoplasma-spp-and-anaplasma-platys-and-severe-anemia-in-dogs-in-thailand
#12
Gunn Kaewmongkol, Nicha Lukkana, Sarawut Yangtara, Sarawan Kaewmongkol, Naris Thengchaisri, Theerapol Sirinarumitr, Sathaporn Jittapalapong, Stanley G Fenwick
Canine tick-borne bacteria; Ehrlichia canis, hemotropic Mycoplasma spp. and Anaplasma spp., are organisms transmitted by Rhipicephalus sanguineus ticks. However, only a few clinical studies evaluating dogs infected with these organisms and anemia condition have been published. In this study, the potential tick-borne bacteria linked to anemia were investigated in eighty-one blood samples selected from anemic dogs using a broad range nested-PCR of the 16S rRNA gene. Positive results were shown in 12/81 blood specimens (14...
March 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28270232/melting-pot-of-tick-borne-zoonoses-the-european-hedgehog-contributes-to-the-maintenance-of-various-tick-borne-diseases-in-natural-cycles-urban-and-suburban-areas
#13
Setareh Jahfari, Sanne C Ruyts, Ewa Frazer-Mendelewska, Ryanne Jaarsma, Kris Verheyen, Hein Sprong
BACKGROUND: European hedgehogs (Erinaceus europaeus) are urban dwellers and host both Ixodes ricinus and Ixodes hexagonus. These ticks transmit several zoonotic pathogens like Borrelia burgdorferi (sensu lato), Anaplasma phagocytophilum, Rickettsia helvetica, Borrelia miyamotoi and "Candidatus Neoehrlichia mikurensis". It is unclear to what extent hedgehogs in (sub) urban areas contribute to the presence of infected ticks in these areas, which subsequently pose a risk for acquiring a tick-borne disease...
March 7, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28267780/the-eurasian-otter-lutra-lutra-as-a-potential-host-for-rickettsial-pathogens-in-southern-italy
#14
Mario Santoro, Nicola D'Alessio, Anna Cerrone, Maria Gabriella Lucibelli, Giorgia Borriello, Gaetano Aloise, Clementina Auriemma, Nunzia Riccone, Giorgio Galiero
Canine monocytic ehrlichiosis and rickettsiosis are zoonotic tick-borne diseases of canids caused by the intracellular obligate bacteria Ehrlichia canis and Rickettsia species respectively. In this study, we investigated using standard and real-time PCR and sequencing, the occurrence and molecular characterization of E. canis and Rickettsia species in the Eurasian otter (Lutra lutra) from the southern Italian population. Samples were screened by using molecular assays also for Neospora caninum, Toxoplasma gondii, Clamydophyla spp...
2017: PloS One
https://www.readbyqxmd.com/read/28264705/improved-molecular-detection-of-babesia-infections-in-animals-using-a-novel-quantitative-real-time-pcr-diagnostic-assay-targeting-mitochondrial-dna
#15
Barbara A Qurollo, Nikole R Archer, Megan E Schreeg, Henry S Marr, Adam J Birkenheuer, Kaitlin N Haney, Brittany S Thomas, Edward B Breitschwerdt
BACKGROUND: Babesiosis is a protozoal, tick transmitted disease found worldwide in humans, wildlife and domesticated animals. Commonly used approaches to diagnose babesiosis include microscopic examination of peripheral blood smears, detection of circulating antibodies and PCR. To screen and differentiate canine Babesia infections many PCR assays amplify the 18S rRNA gene. These sequences contain hypervariable regions flanked by highly conserved regions allowing for amplification of a broad-range of Babesia spp...
March 7, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28261565/borrelia-diversity-and-co-infection-with-other-tick-borne-pathogens-in-ticks
#16
Cristian Raileanu, Sara Moutailler, Ionuţ Pavel, Daniela Porea, Andrei D Mihalca, Gheorghe Savuta, Muriel Vayssier-Taussat
Identifying Borrelia burgdorferi as the causative agent of Lyme disease in 1981 was a watershed moment in understanding the major impact that tick-borne zoonoses can have on public health worldwide, particularly in Europe and the USA. The medical importance of tick-borne diseases has long since been acknowledged, yet little is known regarding the occurrence of emerging tick-borne pathogens such as Borrelia spp., Anaplasma phagocytophilum, Rickettsia spp., Bartonella spp., "Candidatus Neoehrlichia mikurensis", and tick-borne encephalitis virus in questing ticks in Romania, a gateway into Europe...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28259789/evaluation-of-a-serological-test-for-the-diagnosis-of-borrelia-miyamotoi-disease-in-europe
#17
Setareh Jahfari, Denis S Sarksyan, Nadezda M Kolyasnikova, Joppe W Hovius, Hein Sprong, Alexander E Platonov
BACKGROUND: Borrelia miyamotoi causes systemic febrile illness and is transmitted by the same tick species that transmits Borrelia burgdorferi sensu lato and tick-borne encephalitis virus. We describe a serological test using a fragment of glycerophosphodiester phosphodiesterase (GlpQ) as an antigen, and determined its performance in well-defined patient categories. METHODS: Serum of patients with PCR-confirmed Borrelia miyamotoi disease (BMD), Lyme borreliosis (LB), tick-borne encephalitis (TBE), and healthy blood donors (HBD) were collected in Udmurt Republic, Russia...
March 1, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28251517/a-new-strain-of-crimean-congo-hemorrhagic-fever-virus-isolated-from-xinjiang-china
#18
Rong Guo, Shu Shen, Yanfang Zhang, Junming Shi, Zhengyuan Su, Dan Liu, Jinliang Liu, Juan Yang, Qiguo Wang, Zhihong Hu, Yujiang Zhang, Fei Deng
Crimean-Congo hemorrhagic fever virus (CCHFV) is a highly pathogenic tick-borne virus with a fatality rate of up to 50% in humans. CCHFV is widely distributed in countries around the world. Outbreaks of CCHFV infection in humans have occurred in prior years in Xinjiang Province, China. Epidemiological surveys have detected CCHFV RNA in ticks and animals; however, few isolates were identified. In this study, we identified and isolated a new CCHFV strain from Hyalomma asiaticum asiaticum ticks collected from north of Tarim Basin in Xinjiang, China...
February 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28246455/molecular-markers-for-resistance-against-infectious-diseases-of-economic-importance
#19
REVIEW
B M Prajapati, J P Gupta, D P Pandey, G A Parmar, J D Chaudhari
Huge livestock population of India is under threat by a large number of endemic infectious (bacterial, viral, and parasitic) diseases. These diseases are associated with high rates of morbidity and mortality, particularly in exotic and crossbred cattle. Beside morbidity and mortality, economic losses by these diseases occur through reduced fertility, production losses, etc. Some of the major infectious diseases which have great economic impact on Indian dairy industries are tuberculosis (TB), Johne's disease (JD), mastitis, tick and tick-borne diseases (TTBDs), foot and mouth disease, etc...
January 2017: Veterinary World
https://www.readbyqxmd.com/read/28244333/seasonally-biased-or-single-habitat-sampling-is-not-informative-on-the-real-prevalence-of-dermacentor-reticulatus-borne-rickettsiae-a-pilot-study
#20
Sándor Hornok, Marina L Meli, Enikő Gönczi, Regina Hofmann-Lehmann
Dermacentor reticulatus is a tick species of high medical and veterinary importance, emerging in several parts of Europe. Up to now most studies focusing on zoonotic rickettsiae in D. reticulatus were based on ticks collected in a limited part of the questing period, and did not take into account the potential seasonal variations in the rate of infection with tick-borne rickettsiae. The aim of the present study was to investigate the latter phenomenon, i.e. to screen D. reticulatus adults, collected monthly in two urban habitats of Budapest, for the presence of three zoonotic Rickettsia spp...
March 2017: Acta Veterinaria Hungarica
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