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https://www.readbyqxmd.com/read/28520981/clinical-presentation-and-outcomes-of-children-with-human-granulocytic-anaplasmosis
#1
Anna M Schotthoefer, Matthew C Hall, Satya Vittala, Raza Bajwa, Holly M Frost
Background.: Adults with the tick-borne disease human granulocytic anaplasmosis (HGA) have a spectrum of acute febrile illnesses that, if untreated, might be severe. Clinical presentation and outcomes of children with HGA have been poorly described. Methods.: A retrospective analysis was conducted to determine the frequency, presentation, and outcomes of pediatric patients with HGA between 1994 and 2015 in a region of Wisconsin in which HGA is highly endemic. Patients with related International Classification of Diseases Ninth and Tenth Revision (ICD-9 and ICD-10, respectively) codes or positive HGA laboratory test results were evaluated and classified as having had confirmed, probable, or suspected HGA on the basis of the Centers for Disease Control and Prevention (CDC) case definition...
May 16, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28515298/crimean-congo-hemorrhagic-fever-virus-nucleocapsid-protein-augments-mrna-translation
#2
Subbiah Jeeva, Erdong Cheng, Safder S Ganaie, Mohammad A Mir
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne nairovirus of the Bunyaviridae family, causing severe illness with high mortality rates in humans. Here we demonstrate that CCHFV nucleocapsid protein (CCHFV-NP) augments mRNA translation. CCHFV-NP binds to the viral mRNA 5' UTR with high affinity. It facilitates the translation of reporter mRNA both in vivo and in vitro with the assistance of viral mRNA 5' UTR. CCHFV-NP equally favors the translation of both capped and uncapped mRNAs, demonstrating the independence of this translation strategy on the 5' cap...
May 17, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28514953/emergence-of-babesia-canis-in-southern-england
#3
Maria Del Mar Fernández de Marco, Luis M Hernández-Triana, L Paul Phipps, Kayleigh Hansford, E Sian Mitchell, Ben Cull, Clive S Swainsbury, Anthony R Fooks, Jolyon M Medlock, Nicholas Johnson
BACKGROUND: The United Kingdom is considered free of autochthonous transmission of canine babesiosis although cases are reported in dogs associated with recent travel abroad. During the winter months of 2015/16, a cluster of cases of disease in dogs with signs suggestive of canine babesiosis were reported in Harlow, Essex. METHODS: Babesia species were detected in dog blood samples by Giemsa staining of blood smears and by pan-piroplasm PCRs. Babesia species were also detected in extracts of tick DNA using pan-piroplasm PCRs...
May 17, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28512621/spontaneous-acute-subdural-hemorrhage-in-a-patient-with-a-tick-borne-bunyavirus-induced-severe-fever-with-thrombocytopenia-syndrome
#4
Jihwan Yoo, Ji Woong Oh, Chang Gi Jang, Ju Hyung Moon, Eui-Hyun Kim, Jong Hee Chang, Sun Ho Kim, Seok-Gu Kang
We report the first case of severe fever with thrombocytopenia syndrome (SFTS) and a spontaneous acute subdural hematoma (SDH) in Korea. A 79-year-old male presented with fever and thrombocytopenia. On the third day of hospitalization, his mental changed from drowsy to semi-coma. Brain computed tomography indicated an acute subdural hemorrhage on the right convexity. He was given early decompressive craniectomy, but did not survive. Real-time reverse transcription polymerase chain reaction analysis of a blood sample indicated the presence of SFTS virus (SFTSV)...
April 2017: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/28504633/-tick-borne-infections-in-denmark
#5
Bo Bødker Jensen, Lukas Frans Ocias, Nanna Skaarup Andersen, Ram Benny Dessau, Karen Angeliki Krogfelt, Sigurdur Skarphedinsson
The castor bean tick, Ixodes ricinus, is common in woodlands in most of Denmark. Besides Borrelia burgdorferi, it can harbour a number of pathogenic microorganisms such as tick-borne encephalitis virus, Anaplasma phagocytophilum, Rickettsia helvetica, Francisella tularensis, Candidatus Neoehrlichia mikurensis, Bartonella spp., Borrelia miyamotoi and Babesia spp. These tick-borne infections should be a differential diagnostic consideration during the tick season in Denmark. We review the distribution, clinical manifestations, diagnosis and treatment of these microorganisms...
May 15, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28504357/a-nationwide-seroprevalence-screening-for-west-nile-virus-and-tick-borne-encephalitis-virus-in-the-population-of-bulgaria
#6
Iva Christova, Elitsa Panayotova, Simona Tchakarova, Evgenia Taseva, Iva Trifonova, Teodora Gladnishka
To assess local circulation and risk for human infections with West Nile virus (WNV) and Tick-borne encephalitis virus (TBEV) in Bulgaria, a nationwide seroprevalence study was conducted. In total, 1451 residents of all 28 districts in Bulgaria were tested for WNV-specific and TBEV-specific IgG antibodies. The survey found overall seroprevalence of 1.5% and 0.6%, respectively. The highest WNV seroprevalence was found in Sofia Province and districts near the river Danube. TBEV circulation was detected among residents of 6 districts...
May 15, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28503490/the-distinct-transcriptional-response-of-the-midgut-of-amblyomma-sculptum-and-amblyomma-aureolatum-ticks-to-rickettsia-rickettsii-correlates-to-their-differences-in-susceptibility-to-infection
#7
Larissa A Martins, Maria F B de Melo Galletti, José M Ribeiro, André Fujita, Francisco B Costa, Marcelo B Labruna, Sirlei Daffre, Andréa C Fogaça
Rickettsia rickettsii is a tick-borne obligate intracellular bacterium that causes Rocky Mountain Spotted Fever (RMSF). In Brazil, two species of ticks in the genus Amblyomma, A. sculptum and A. aureolatum, are incriminated as vectors of this bacterium. Importantly, these two species present remarkable differences in susceptibility to R. rickettsii infection, where A. aureolatum is more susceptible than A. sculptum. In the current study, A. aureolatum and A. sculptum ticks were fed on suitable hosts previously inoculated with R...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28501619/a-label-free-immunoassay-for-flavivirus-detection-by-the-reflective-phantom-interface-technology
#8
Giovanni Tagliabue, Valentina Faoro, Serena Rizzo, Daniele Sblattero, Andrea Saccani, Gabriele Riccio, Tommaso Bellini, Matteo Salina, Marco Buscaglia, Alessandro Marcello
Members of Flaviviridae are widespread and cause clinically relevant arboviral diseases that impact locally and as imported travel-related infections. Direct detection of viraemia is limited, being typically undetectable at onset of symptoms. Therefore, diagnosis is primarily based on serology, which is complicated by high cross-reactivity across different species. The overlapping geographical distribution of the vectors in areas with a weak healthcare system, the increase of international travel and the similarity of symptoms highlight the need for rapid and reliable multi-parametric diagnostic tests in point-of-care formats...
May 10, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28500292/fitness-estimates-from-experimental-infections-predict-the-long-term-strain-structure-of-a-vector-borne-pathogen-in-the-field
#9
Jonas Durand, Maxime Jacquet, Olivier Rais, Lise Gern, Maarten J Voordouw
The populations of many pathogen species consist of a collection of common and rare strains but the factors underlying this strain-specific variation in frequency are often unknown. Understanding frequency variation among strains is particularly challenging for vector-borne pathogens where the strain-specific fitness depends on the performance in both the vertebrate host and the arthropod vector. Two sympatric multiple-strain tick-borne pathogens, Borrelia afzelii and B. garinii, that use the same tick vector, Ixodes ricinus, but different vertebrate hosts were studied...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28498740/powassan-virus-an-emerging-arbovirus-of-public-health-concern-in-north-america
#10
Meghan E Hermance, Saravanan Thangamani
Powassan virus (POWV, Flaviviridae) is the only North American member of the tick-borne encephalitis serogroup of flaviviruses. It is transmitted to small- and medium-sized mammals by Ixodes scapularis, Ixodes cookei, and several other Ixodes tick species. Humans become infected with POWV during spillover transmission from the natural transmission cycles. In humans, POWV is the causative agent of a severe neuroinvasive illness with 50% of survivors displaying long-term neurological sequelae. POWV was recognized as a human pathogen in 1958 when a young boy died of severe encephalitis in Powassan, Ontario, and POWV was isolated from the brain autopsy of this case...
May 12, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28495200/genotyping-of-theileria-lestoquardi-from-sheep-and-goats-in-sudan-to-support-control-of-malignant-ovine-theileriosis
#11
A M Ali, D A Salih, M N Njahira, S K Hassan, A M El Hussein, Z Liu, H Yin, R Pelle, R A Skilton
Theileriosis, caused by parasitic protozoa of the genus Theileria parasites, are among the major tick-borne diseases of ruminant livestock. The largest economic losses are attributed in particular to those caused by the leukoproliferative species of Theileria: T. parva, T. annulata and T. lestoquardi. Theileria lestoquardi is transmitted by Hyalomma ticks and causes malignant ovine theileriosis (MOT), a disease that is particularly prevalent in Sudan. The disease is considered of a high economic importance in Sudan, where export of sheep is a major component of the national economy...
May 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28482001/crimean-congo-hemorrhagic-fever-in-humanized-mice-reveals-glial-cells-as-primary-targets-of-neurological-infection
#12
Jessica R Spengler, M Kelly Keating, Anita K McElroy, Marko Zivcec, JoAnn D Coleman-McCray, Jessica R Harmon, Brigid C Bollweg, Cynthia S Goldsmith, Éric Bergeron, James G Keck, Sherif R Zaki, Stuart T Nichol, Christina F Spiropoulou
Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral hemorrhagic disease seen exclusively in humans. Central nervous system (CNS) infection and neurological involvement have also been reported in CCHF. Here we inoculated NSGTM-SGM3 mice engrafted with human hematopoietic CD34+ stem cells with low passage CCHF virus strains isolated from human patients. Humanized mice develop lethal disease characterized by histopathological change in the liver and brain. To date, targets of neuroinfection and neuropathology have not been investigated in CCHF...
May 8, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28480803/validation-of-an-improved-anaplasma-antibody-competitive-elisa-for-detection-of-anaplasma-ovis-antibody-in-domestic-sheep
#13
Kathleen L Mason, Michael V Gonzalez, Chungwon Chung, Michelle R Mousel, Stephen N White, Joshua B Taylor, Glen A Scoles
An accurate and simple-to-perform new version of a competitive ELISA (cELISA) kit that became commercially available in 2015 for testing of cattle for antibody to Anaplasma marginale was validated for detection of Anaplasma ovis antibody in domestic sheep. True positives and negatives were identified using nested PCR (nPCR) as the gold standard. Negative bovine control sera supplied with the kit were used to calculate % inhibition (%I), designated bovine control ELISA (BcELISA), and this was compared to %I calculated from negative ovine sera derived from hand-raised, pathogen-free sheep, designated ovine control ELISA (OcELISA)...
May 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28479064/detection-of-a-novel-putative-phlebovirus-and-first-isolation-of-dugbe-virus-from-ticks-in-accra-ghana
#14
Daisuke Kobayashi, Mitsuko Ohashi, Joseph H N Osei, Esinam Agbosu, Millicent Opoku, Alfred Agbekudzi, Joannitta Joannides, Ryosuke Fujita, Toshinori Sasaki, J H Kofi Bonney, Samuel Dadzie, Haruhiko Isawa, Kyoko Sawabe, Nobuo Ohta
Ticks are ectoparasites that transmit various types of human and animal pathogens. In particular, emerging and re-emerging diseases caused by tick-borne viruses are public health concerns around the world. However, in many countries of the sub-Saharan African region, epidemiological information on tick-borne viral infections is limited, and their prevalence and distribution remain largely unknown. In this study, we conducted surveillance on ticks to detect medically important tick-borne bunyaviruses in three study sites in and near to Accra, the capital city of Ghana, in 2015...
April 23, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28468299/historical-perspectives-on-flavivirus-research
#15
REVIEW
Michael R Holbrook
The flaviviruses are small single-stranded RNA viruses that are typically transmitted by mosquito or tick vectors. These "arboviruses" are found around the world and account for a significant number of cases of human disease. The flaviviruses cause diseases ranging from mild or sub-clinical infections to lethal hemorrhagic fever or encephalitis. In many cases, survivors of neurologic flavivirus infections suffer long-term debilitating sequelae. Much like the emergence of West Nile virus in the United States in 1999, the recent emergence of Zika virus in the Americas has significantly increased the awareness of mosquito-borne viruses...
April 30, 2017: Viruses
https://www.readbyqxmd.com/read/28461151/mapping-the-distribution-of-tick-borne-encephalitis-in-mainland-china
#16
Ruo-Xi Sun, Sheng-Jie Lai, Yang Yang, Xin-Lou Li, Kun Liu, Hong-Wu Yao, Hang Zhou, Yu Li, Li-Ping Wang, Di Mu, Wen-Wu Yin, Li-Qun Fang, Hong-Jie Yu, Wu-Chun Cao
Tick-borne encephalitis (TBE) has become an increasing public health threat in recent years, ranging from Europe, through far-eastern Russia to Japan and northern China. However, the neglect of its expansion and scarce analyses of the dynamics have made the overall disease burden and the risk distribution of the disease being unclear in mainland China. In this study, we described epidemiological characteristics of 2117 reported human TBE cases from 2006 to 2013 in mainland China. About 99% of the cases were reported in forest areas of northeastern China, and 93% of reported infections occurred during May-July...
April 17, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28457821/a-retrospective-study-of-the-characterization-of-rickettsia-species-in-ticks-collected-from-humans
#17
Valeria Blanda, Alessandra Torina, Francesco La Russa, Rosalia D'Agostino, Kety Randazzo, Salvatore Scimeca, Elisabetta Giudice, Santo Caracappa, Antonio Cascio, José de la Fuente
Rickettsiae (family Rickettsiaceae, order Rickettsiales) are obligate intracellular bacteria transmitted by arthropod vectors. Several Rickettsia species causing vector-borne rickettsioses belong to the spotted fever group (SFG). Traditionally, Rickettsia conorii has been considered as the main etiologic agent of Mediterranean spotted fever. However, the molecular characterization of rickettsiae allowed identifying other species involved in spotted fever in the Mediterranean region. In this study, 42 ticks collected from humans were subjected to morphological identification and molecular characterization of Rickettsia species potentially involved in human rickettsiosis in Sicily...
April 12, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28457353/tick-borne-emerging-infections-ehrlichiosis-and-anaplasmosis
#18
REVIEW
Nahed Ismail, Jere W McBride
Human ehrlichiosis and anaplasmosis are acute febrile tick-borne infectious diseases caused by various members from the genera Ehrlichia and Anaplasma. Ehrlichia chaffeensis is the major etiologic agent of human monocytotropic ehrlichiosis (HME), while Anaplasma phagocytophilum is the major cause of human granulocytic anaplasmosis (HGA). The clinical manifestations of HME and HGA ranges from subclinical to potentially life-threatening diseases associated with multi-organ failure. Macrophages and neutrophils are the major target cells for Ehrlichia and Anaplasma, respectively...
June 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/28455331/reverse-line-blot-based-detection-approaches-of-microbial-pathogens-in-ixodes-ricinus-ticks-collected-in-austria-and-impact-of-the-chosen-method
#19
Anna-Margarita Schötta, Michiel Wijnveld, Hannes Stockinger, Gerold Stanek
Ticks transmit a large number of pathogens capable of causing human disease. In this study, the PCR-reverse line blot (RLB) method was used to screen for pathogens in a total of 554 Ixodes ricinus ticks collected from all provinces of Austria. These pathogens belong to the genera Borrelia, Rickettsiae, Anaplasma/(Neo-)Ehrlichia, Babesia, and CoxiellaThe pathogens with the highest detected prevalence were spirochetes of the Borrelia burgdorferi sensu lato complex, in 142 ticks (25.6%). B. afzelii (80/142) was the most frequently detected species, followed by B...
April 28, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28453842/a-cluster-of-fatal-tick-borne-encephalitis-virus-infection-in-organ-transplant-setting
#20
Dariusz Lipowski, Marta Popiel, Karol Perlejewski, Shota Nakamura, Iwona Bukowska-Osko, Ewa Rzadkiewicz, Tomasz Dzieciatkowski, Anna Milecka, Wojciech Wenski, Michal Ciszek, Alicja Debska-Slizien, Ewa Ignacak, Kamila Caraballo Cortes, Agnieszka Pawelczyk, Andrzej Horban, Marek Radkowski, Tomasz Laskus
Background.: Tick-borne encephalitis virus (TBEV) infection has become a major health problem in Europe and is currently a common cause of viral brain infection in many countries. Encephalitis in transplant recipients, althrough rare, is becoming a recognized complication. Our study provides the first description of transmission of TBEV through transplantation of solid organs. Methods.: Three patients who received solid organ transplants from a single donor (2 received kidney, and 1 received liver) developed encephalitis 17-49 days after transplantation and subsequently died...
March 15, 2017: Journal of Infectious Diseases
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