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3-D Conformal Radiotherapy

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https://www.readbyqxmd.com/read/28048366/su-f-t-632-on-the-use-of-intensity-modulated-arc-therapy-for-thoracic-vertebral-metastases-sbrt-treatment
#1
D Pokhrel, M Mallory, R Badkul, H Jiang, H Saleh, F Wang, C Lominska
PURPOSE: To retrospectively evaluate quality, efficiency and delivery accuracy of intensity modulated arc therapy (IMAT) plans for thoracic-vertebral metastases using stereotactic body radiotherapy (SBRT). METHODS: After obtaining approval of RPC-benchmark plan, seven previously treated thoracic-vertebral metastases patients with non-coplanar hybrid arcs(NC-HA)using 1-2 3D-dynamic conformal partial-arcs plus 7-9 IMRT-beams were re-optimized with IMAT using 3 full co-planar arcs...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047646/su-f-t-606-monte-carlo-evaluation-of-tissue-inhomogeneity-corrections-in-the-treatment-of-liver-cancer-patients-using-stereotactic-body-radiotherapy
#2
D Pokhrel, S Sood, R Badkul, C McClinton, H Jiang, H Saleh, C Lominska
PURPOSE: To evaluate the dosimetric performance of X-ray Voxel Monte Carlo(XVMC) algorithm in effort to clinically validate Monte Carlo-approach in heterogeneous liver phantom and liver SBRT plans. METHODS: An anthropomorphic RPC liver phantom incorporating a liver structure with two cylindrical targets and organs-at-risk (OARs) was used in phantom validation. Subsequently, five patients with metastatic liver cancer were treated using heterogeneity-corrected pencil-beam(PB-hete)algorithm were analyzed following RTOG-1112 criteria ...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047564/su-f-j-221-adjusted-dose-and-its-relation-to-radiation-induced-liver-disease-during-hepatocellular-carcinoma-radiotherapy
#3
P Huang, H Li, J Chen, C Ma, Y Gang, S Qin, Y Yin, D Li
PURPOSE: Many patients with hepatocellular carcinoma (HCC) had hepatic anatomy variations as a result of inter-fraction deformation during fractionated radiotherapy, which may result in difference from the planned dose. This study aimed to investigate the relationship between adjusted dose and radiation induced liver disease (RILD) in HCC patients receiving three dimensional conformal radiotherapy (3DCRT). METHODS: Twenty-three HCC patients received conventional fractionated 3DCRT were enrolled in this retrospective investigation...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047202/su-f-t-358-is-auto-planning-useful-for-volumetric-modulated-arc-therapy-planning-in-rectal-cancer-radiotherapy
#4
K Li, X Chang, J Wang, P Hu, W Hu
PURPOSE: To evaluate whether Auto-Planning based volumetric-modulated radiotherapy (auto-VMAT) can reduce manual interaction time during treatment planning and improve plan quality for rectal cancer radiotherapy. METHODS: Ten rectal cancer patients (stage II and III) after radical resection using Dixon surgery were enrolled. All patients were treated with VMAT technique. The manual VMAT plans (man-VMAT) were designed in the Pinnacle treatment planning system (Version 9...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047193/th-ab-brb-01-trajectory-modulated-arc-therapy-application-to-partial-breast-irradiation
#5
D Hristov
: Current state-of-the art digital C-arm medical linear accelerators are capable of delivering radiation treatments with high level of automation, which affords coordinated motions of gantry, couch, and multileaf collimator (MLC) with dose rate modulations. The new machine capacity has shown the potential to bring substantially improved radiation dosimetry and/or delivery efficiency to many challenging diseases. Combining an integrated beam orientation optimization algorithm with automated machine navigation, markedly improved dose conformity has been achieved using 4ρ therapy...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046862/mo-fg-bra-04-a-novel-time-weighted-density-correction-for-stereotactic-lung-radiotherapy-a-phantom-study
#6
D Mohatt, H Malhotra
PURPOSE: Conventional treatment plans for lung radiotherapy are created using either the free breathing (FB) scheme which represents the tumor at an arbitrary breathing phase of the patient's respiratory cycle, or the average computed tomography (ACT) intensity projection over 10-binned phases. Neither method is entirely accurate because of the absence of time dependence of tumor movement. In the present "Hybrid" method, the HU of tumor in 3D space is determined by relative weighting of the HU of the tumor and lung in proportion to the time they spend at that location during the entire breathing cycle...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28041316/cyberknife-stereotactic-radiosurgery-for-the-treatment-of-symptomatic-vertebral-hemangiomas-a-single-institution-experience
#7
Michael Zhang, Yi-Ren Chen, Steven D Chang, Anand Veeravagu
OBJECTIVE Symptomatic vertebral hemangiomas (SVHs) are a very rare pathology that can present with persistent pain or neurological deficits that warrant surgical intervention. Given the relative rarity and difficulty in assessment, the authors sought to present a dedicated series of SVHs treated using stereotactic radiosurgery (SRS) to provide insight into clinical decision making. METHODS A retrospective review of a single institution's experience with hypofractionated radiosurgery for SVH from 2004 to 2011 was conducted to determine the clinical and radiographic outcomes following SRS treatment...
January 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/27868212/myelodysplastic-syndromes-and-acute-myeloid-leukemia-after-radiotherapy-for-prostate-cancer-a-population-based-study
#8
Rong Wang, Amer M Zeidan, James B Yu, Pamela R Soulos, Amy J Davidoff, Steven D Gore, Scott F Huntington, Cary P Gross, Xiaomei Ma
BACKGROUND: To understand the impact of radiotherapy on the development of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) among elderly prostate cancer patients. METHODS: We performed a retrospective cohort study of elderly prostate cancer patients diagnosed during 1999-2011 by using the National Cancer Institute's Surveillance, Epidemiology and End Results-Medicare linked database. Competing risk analyses adjusting for patient characteristics were conducted to assess the impact of radiotherapy on the development of subsequent MDS/AML, compared with surgery...
November 21, 2016: Prostate
https://www.readbyqxmd.com/read/27863019/78gy-with-fiducial-marker-image-guided-radiotherapy-in-prostate-cancer-single-center-analysis-of-301-patients
#9
Ee Siang Choong, George Hruby, Jean Yang, Carol Kwong, Nitya Patanjali
AIM: In prostate cancer, fiducial marker image-guided radiotherapy (FMIGRT) allows correction of setup errors and interfraction physiological motion resulting in improved accuracy of target and sparing of at risk organs. We aim to report outcomes and toxicities observed in patients treated with dose escalation to 78Gy with FMIGRT in our center. METHODS AND MATERIALS: Retrospective review of consecutive patients with histologically confirmed T1-4N0M0 localized prostate cancer treated with dose escalation to 78Gy with FMIGRT in our center...
November 10, 2016: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27790562/toxicity-profile-of-imrt-vs-3d-crt-in-head-and-neck-cancer-a-retrospective-study
#10
Gopa Ghosh, Ramanjis Tallari, Anupam Malviya
INTRODUCTION: Role of radiotherapy in comprehensive management of head and neck cancer for achieving tumour control and organ preservation is now well established and radiotherapy is routinely used in adjuvant setting after surgery, concurrently with chemotherapy or targeted agents and for palliation. Development of linear accelerator with Multileaf Collimator (MLC) have revolutionized radiation delivery techniques, allowing conformal and Intensity Modulated Radiotherapy (IMRT) to deliver highly conformal sculpted radiation dose to a very complex structure with improved sparing of adjoining critical structures like salivary glands, spinal cord, eyes, brainstem and larynx amounting to better therapeutic gain...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27765542/dosimetric-comparison-of-helical-tomotherapy-intensity-modulated-radiation-therapy-volumetric-modulated-arc-therapy-and-3-dimensional-conformal-therapy-for-the-treatment-of-t1n0-glottic-cancer
#11
Kemal Ekici, Eda K Pepele, Bahaddin Yaprak, Oztun Temelli, Aysun F Eraslan, Nadir Kucuk, Ayse Y Altınok, Pelin A Sut, Ozlem D Alpak, Cemil Colak, Alpaslan Mayadagli
Various radiotherapy planning methods for T1N0 laryngeal cancer have been proposed to decrease normal tissue toxicity. We compare helical tomotherapy (HT), linac-based intensity-modulated radiation therapy (IMRT), volumetric-modulated arc therapy (VMAT), and 3-D conformal radiotherapy (3D-CRT) techniques for T1N0 laryngeal cancer. Overall, 10 patients with T1N0 laryngeal cancer were selected and evaluated. Furthermore, 10 radiotherapy treatment plans have been created for all 10 patients, including HT, IMRT, VMAT, and 3D-CRT...
January 2016: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/27764686/concurrent-irradiation-with-the-anti-programmed-cell-death-ligand-1-immune-checkpoint-blocker-durvalumab-single-centre-subset-analysis-from-a-phase-1-2-trial
#12
Antonin Levy, Christophe Massard, Jean-Charles Soria, Eric Deutsch
PURPOSE: To assess preliminary safety and efficacy results of the anti-programmed cell death ligand-1 (anti-PD-L1) durvalumab in combination with radiotherapy (RT) in an expansion cohort of patients included in a phase 1/2 trial at our institution. PATIENTS AND METHODS: Data from patients who received concurrent palliative RT with durvalumab (10 mg/kg every 2 weeks via intravenous infusion) were analysed in terms of safety (CTCAE v4.0) and efficacy (RECIST v1.1 and tumour growth rate [TGR])...
November 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27531481/-technical-advancement-improves-survival-in-patients-with-locally-advanced-non-small-cell-lung-cancer-la-nsclc-receiving-definitive-radiotherapy
#13
J B Wang, W Jiang, Z Ji, J Z Cao, L P Liu, Y Men, C Xu, X Z Wang, Z G Hui, J Liang, J M Lyu, Z M Zhou, Z F Xiao, Q F Feng, D F Chen, H X Zhang, W B Yin, L H Wang
OBJECTIVE: This study aimed to evaluate the impact of technical advancement of radiation therapy in patients with LA-NSCLC receiving definitive radiotherapy (RT). METHODS: Patients treated with definitive RT (≥50 Gy) between 2000 and 2010 were retrospectively reviewed. Overall survival (OS), cancer specific survival (CSS), locoregional progression-free survival (LRPFS), distant metastasis-free survival (DMFS) and progression-free survival (PFS) were calculated and compared among patients irradiated with different techniques...
August 2016: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/27452754/-short-term-efficacy-comparison-between-preoperative-three-dimensional-conformal-radiotherapy-and-volumetric-modulated-arc-therapy-concurrently-combined-with-chemotherapy-in-the-treatment-of-locally-advanced-rectal-carcinoma
#14
Lin Xiao, Xin Yu, Yujia Zhu, Weiwei Xiao, Zhifan Zeng, Mengzhong Liu, Rong Zhang, Yuanhong Gao
OBJECTIVE: To compare the short-term efficacy and treatment-related adverse reaction between preoperative three dimensional conformal radiotherapy (3D-CRT) and volumetric modulated arc therapy (VMAT) concurrently combined with chemotherapy in the treatment of locally advanced rectal carcinoma (LARC). METHODS: Clinical data of 334 patients with LARC undergoing preoperative 3D-CRT(172 cases) or VMAT(162 cases) with concurrent Xelox chemotherapy (main protocol: capecitabine plus oxaliplatin) and surgery in Sun Yat-sen University Cancer Center from May 2007 to April 2013 were retrospectively analyzed...
July 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27355127/a-new-three-dimensional-conformal-radiotherapy-3dcrt-technique-for-large-breast-and-or-high-body-mass-index-patients-evaluation-of-a-novel-fields-assessment-aimed-to-reduce-extra-target-tissue-irradiation
#15
Stimato Gerardina, Ippolito Edy, Silipigni Sonia, Di Venanzio Cristina, Rinaldi Carla Germana, Gaudino Diego, Fiore Michele, Trodella Lucio, D'Angelillo Rolando Maria, Ramella Sara
OBJECTIVE: To develop an alternative three-dimensional treatment plan with standardized fields class solution for whole-breast radiotherapy in patients with large/pendulous breast and/or high body mass index (BMI). METHODS: Two treatment plans [tangential fields and standardized five-fields technique (S5F)] for a total dose of 50 Gy/25 fractions were generated for patients with large breasts [planning target volume (PTV) >1000 cm(3) and/or BMI >25 kg m(-2)], supine positioned...
September 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27334276/intensity-modulated-proton-therapy-volumetric-modulated-arc-therapy-and-3d%C3%A2-conformal-radiotherapy-in-anaplastic-astrocytoma-and-glioblastoma-a-dosimetric-comparison
#16
S Adeberg, S B Harrabi, N Bougatf, D Bernhardt, J Rieber, S A Koerber, M Syed, T Sprave, A Mohr, A Abdollahi, T Haberer, S E Combs, K Herfarth, J Debus, S Rieken
PURPOSE: The prognosis for high-grade glioma (HGG) patients is poor; thus, treatment-related side effects need to be minimized to conserve quality of life and functionality. Advanced techniques such as proton radiation therapy (PRT) and volumetric-modulated arc therapy (VMAT) may potentially further reduce the frequency and severity of radiogenic impairment. MATERIALS AND METHODS: We retrospectively assessed 12 HGG patients who had undergone postoperative intensity-modulated proton therapy (IMPT)...
June 22, 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27306779/dosimetric-comparison-of-axilla-and-groin-radiotherapy-techniques-for-high-risk-and-locally-advanced-skin-cancer
#17
Malcolm D Mattes, Ying Zhou, Sean L Berry, Christopher A Barker
PURPOSE: Radiation therapy targeting axilla and groin lymph nodes improves regional disease control in locally advanced and high-risk skin cancers. However, trials generally used conventional two-dimensional radiotherapy (2D-RT), contributing towards relatively high rates of side effects from treatment. The goal of this study is to determine if three-dimensional conformal radiation therapy (3D-CRT), intensity-modulated radiation therapy (IMRT), or volumetric-modulated arc therapy (VMAT) may improve radiation delivery to the target while avoiding organs at risk in the clinical context of skin cancer regional nodal irradiation...
June 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/27184943/acute-and-late-genitourinary-toxicity-after-72-gy-of-conventionally-fractionated-conformal-radiotherapy-for-localised-prostate-cancer-impact-of-individual-and-clinical-parameters
#18
V Stankovic, Z Džamic, T Pekmezovic, D K Tepavcevic, M Dozic, M Saric, S Vuckovic, M Nikitovic
AIM: Our aim was to estimate the incidence of acute and late genitourinary toxicity in patients treated with three-dimensional conformal radiotherapy (3DCRT) for localised prostate cancer and to estimate the possible influence of individual and clinical characteristics. MATERIALS AND METHODS: Between September 2009 and September 2013, 225 patients with localised prostate cancer were treated with 3DCRT. Ninety-four patients with an estimated risk of lymph node involvement ≤15%, according to the Roach formula, were evaluated in this study...
September 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27146749/clinical-significance-of-geographic-miss-when-using-conventional-four-field-radiotherapy-technique-in-treatment-of-locally-advanced-carcinoma-cervix
#19
A Gulia, F D Patel, C Santam, R Bhavana, K Reena, S C Sharma
BACKGROUND: Although conventional four- field radiotherapy based on bony landmarks has been traditionally used, areas of geographical miss due to individual variation in pelvic anatomy have been identified with advanced imaging techniques. AIMS: The primary aim of this study is to evaluate the geographical miss in patientswhen using the conventional four-field planningplanning and to find out the impact of 3-D conformal CT based in patients with locally advanced carcinoma cervix...
January 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/27002946/axillary-coverage-by-whole-breast-irradiation-in-1-to-2-positive-sentinel-lymph-nodes-in-breast-cancer-patients
#20
Maria Carmen De Santis, Francesca Bonfantini, Michela Dispinzieri, Silvia Meroni, Barbara Diletto, Elisa D Mantero, Marzia Franceschini, Fulvia Soncini, Serena Di Cosimo, Vito Cosentino, Emanuele Pignoli, Laura Lozza
PURPOSE: To evaluate the dosimetric coverage of axillary levels I, II, and III obtained with standard whole breast irradiation in 1 to 2 positive sentinel lymph nodes (SLNs) patients not submitted to axillary lymph nodes dissection (ALND), and to compare the lymph nodes areas coverage obtained with 3D conformal radiation therapy, intensity-modulated radiotherapy (IMRT), and volumetric modulated arc therapy (VMAT). METHODS: Patients with 1 to 2 positive SLNs undergoing breast-conserving therapy, without ALND, were included in the analysis...
August 3, 2016: Tumori
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