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3-D Conformal Radiotherapy

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https://www.readbyqxmd.com/read/29101643/dosimetric-comparison-of-3-dimensional-conformal-radiotherapy-volumetric-modulated-arc-therapy-and-helical-tomotherapy-for-postoperative-gastric-cancer-patients
#1
Cem Onal, Yemliha Dölek, Berna Akkuş Yıldırım
PURPOSE: To compare dosimetric data for the planning target volume (PTV) and organs at risk (OARs) between 3-dimensional conformal radiotherapy (3DCRT), volumetric modulated arc therapy (VMAT), and helical tomotherapy [1]. MATERIALS AND METHODS: The dosimetric data for 15 gastric cancer patients treated with 3DCRT, VMAT, or HT techniques were used. Cumulative dosimetric parameters, homogeneity index (HI), and conformal index (CI) were compared for the PTV and OARs...
November 3, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29097074/a-phase-ii-toxicity-end-point-trial-icorg-99-09-of-accelerated-dose-escalated-hypofractionated-radiation-in-non-small-cell-lung-cancer
#2
D N Cagney, P G Thirion, M T Dunne, C Fleming, D Fitzpatrick, C M O'Shea, M A Finn, S O'Sullivan, C Booth, C D Collins, S J Buckney, A Shannon, J G Armstrong
AIMS: The objective of this phase II clinical trial was to prospectively evaluate the safety and efficacy of accelerated hypofractionated three-dimensional conformal radiation therapy (3DCRT) in localised non-resectable/non-operable non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: Sixty patients with stage I-III NSCLC were enrolled in a prospective single-arm All Ireland Co-operative Oncology Research Group (ICORG 99-09) toxicity end point phase II trial...
October 30, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29060966/-clinical-study-of-intensity-modulated-radiotherapy-and-three-dimensional-conformal-radiotherapy-with-three-dimensional-brachytherapy-and-concurrent-chemotherapy-for-patients-with-advanced-cervical-cancer
#3
COMPARATIVE STUDY
X X Du, H Yang, H J Zhang, L A Li, W S Fan, Y G Meng
Objective: To compare the dose, clinical efficacy and acute adverse reactions of intensity modulated radiotherapy (IMRT) and three-dimensional conformal radiotherapy (3D-CRT) combined with three-dimensional brachytherapy (3D-BT) in the treatment of concurrent radiotherapy and chemotherapy for advanced stage cervical cancer patients. Methods: Data collection was performed from January 2011 to November 2015 in Chinese PLA General Hospital and Inner Mongolia Cancer Hospital. All 89 patients with advanced stage (Ⅱ b-Ⅲ b) cervical cancer were treated by pelvic radiotherapy and concurrent chemotherapy, 46 cases of them received IMRT and 3D-BT (IMRT group) , 43 cases received 3D-CRT and 3D-BT (3D-CRT group) , along with cisplatin chemotherapy...
October 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29031904/definitive-radiotherapy-for-a-head-and-neck-merkel-cell-carcinoma-and-comprehensive-nodal-volumes-a-case-for-using-a-computer-designed-variable-thickness-compensator-to-reduce-risk-and-severity-of-mucositis
#4
Anesa Ahamad, Donald T Weed, Darel D Pruett, Daniel Saulpaugh, Womah Neeranjun, Eduardo Fernandez
When contemplating how to treat head and neck primary cancers and regional lymph nodes with radiotherapy, we often select the contemporary intensity-modulated radiotherapy (IMRT) without much consideration of older methods that may give fewer side effects and be more cost-effective. For an 87-year-old female with a 1.5-cm Merkel cell carcinoma (MCC) located 1.5 cm lateral to the orbital rim, we were challenged to deliver 50 Gy to comprehensive elective nodal regions and 70 Gy to the primary. We were particularly concerned about the potential adverse acute effects of radiotherapy to mucosal structures in this elderly female...
October 11, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28943927/measurement-of-exhaled-nitric-oxide-and-serum-surfactant-protein-d-levels-for-monitoring-radiation-pneumonitis-following-thoracic-radiotherapy
#5
Hideya Yamazaki, Norihiro Aibe, Satoaki Nakamura, Naomi Sasaki, Gen Suzuki, Ken Yoshida, Kei Yamada, Masahiko Koizumi, Taichiro Arimoto, Yoshinobu Iwasaki, Yoshiko Kaneko, Koichi Takayama
The present study aimed to examine the role of exhaled nitric oxide (eNO) and serum surfactant protein D (SP-D) level in the determination of radiation pneumonitis (RP) after thoracic radiotherapy (RT). The study included 34 treatments for 33 patients, including 16 three-dimensional conformal and 18 stereotactic body RT treatments. eNO levels were measured prior to RT, immediately subsequent to RT, every week during the RT course and at 1, 3, 6, 9 and 12 months following the treatment. The therapy reduced the eNO from 24...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28882511/-doses-to-organs-at-risk-for-conformational-and-stereotactic-radiotherapy-bladder
#6
REVIEW
L Duvergé, J Castelli, T Lizée, R de Crevoisier, D Azria
Bladder dose constraints in case of conformational radiotherapy/intensity-modulated radiotherapy and stereotactic radiotherapy are reported from the literature, in particular from the French radiotherapy society RECORAD recommendations, according to the treated pelvic tumor sites. The dose-volume effect on urinary toxicity is not clearly demonstrated, making difficult to establish absolute dose constraints for the bladder. In case of high-dose prostate cancer radiotherapy, the bladder dose constraints are: V60Gy<50% and maximum dose<80Gy for standard fractionation and V60Gy<5%, V48Gy<25% and V41Gy<50% for moderate hypofractionation (20 fractions of 3Gy)...
October 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28870525/rectal-balloon-use-limits-vaginal-displacement-rectal-dose-and-rectal-toxicity-in-patients-receiving-imrt-for-postoperative-gynecological-malignancies
#7
Cheng-Chia Wu, Yen-Ruh Wuu, Theodore Yanagihara, Ashish Jani, Eric P Xanthopoulos, Akhil Tiwari, Jason D Wright, William M Burke, June Y Hou, Ana I Tergas, Israel Deutsch
Pelvic radiotherapy for gynecologic malignancies traditionally used a 4-field box technique. Later trials have shown the feasibility of using intensity-modulated radiotherapy (IMRT) instead. But vaginal movement between fractions is concerning when using IMRT due to greater conformality of the isodose curves to the target and the resulting possibility of missing the target while the vagina is displaced. In this study, we showed that the use of a rectal balloon during treatment can decrease vaginal displacement, limit rectal dose, and limit acute and late toxicities...
September 1, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28759114/nonrhabdomyosarcoma-soft-tissue-sarcoma-nrsts-in-pediatric-and-young-adult-patients-results-from-a-prospective-study-using-limited-margin-radiotherapy
#8
Christopher L Tinkle, Israel Fernandez-Pineda, April Sykes, Zhaohua Lu, Chia-Ho Hua, Michael D Neel, Armita Bahrami, Barry L Shulkin, Sue C Kaste, Alberto Pappo, Sheri L Spunt, Matthew J Krasin
BACKGROUND: Indications for and delivery of adjuvant therapies for pediatric nonrhabdomyosarcoma soft tissue sarcoma (NRSTS) have been derived largely from adult studies; therefore, significant concern remains regarding radiation exposure to normal tissue. The authors report long-term treatment outcomes and toxicities for pediatric and young adult patients with high-grade NRSTS who were treated on a prospective trial using limited-margin radiotherapy. METHODS: Sixty-two patients (ages 3-22 years) with predominantly high-grade NRSTS requiring radiation were treated on a phase 2 institutional study of conformal external-beam radiotherapy and/or brachytherapy using a 1...
November 15, 2017: Cancer
https://www.readbyqxmd.com/read/28741749/clinical-outcomes-after-local-field-conformal-reirradiation-of-patients-with-retropharyngeal-nodal-metastasis
#9
Courtney Pollard, Theresa P Nguyen, Sweet Ping Ng, Steven J Frank, Adam S Garden, Gary B Gunn, Clifton D Fuller, Beth M Beadle, William H Morrison, Shah J Shah, He Wang, Sam Tung, Conjun Wang, Lawrence D Ginsberg, Mark E Zafereo, Erich M Sturgis, Shirley Y Su, Ehab Y Hanna, David I Rosenthal, Jack Phan
BACKGROUND: The purpose of this study was to present our experience with retropharyngeal node reirradiation using highly conformal radiotherapy (RT). METHODS: A retrospective screen of 2504 consecutively irradiated patients with head and neck malignancies between 2005 and 2015 identified 19 patients who underwent reirradiation for retropharyngeal node metastasis. Clinical and toxicity outcomes were assessed in these patients. RESULTS: Thirteen patients (68%) had squamous cell carcinoma...
October 2017: Head & Neck
https://www.readbyqxmd.com/read/28550674/-a-comparison-of-dosimetric-variance-for-external-beam-partial-breast-irradiation-using-three-dimensional-and-four-dimensional-computed-tomography
#10
COMPARATIVE STUDY
B Guo, J B Li, W Wang, M Xu, Q Shao, T H Liu
Objective: To investigate the potential dosimetric benefits of four-dimensional computed tomography (4DCT) compared to three-dimensional CT (3DCT) in the planning of radiotherapy for external-beam partial breast irradiation (EB-PBI). Methods: Three-DCT and 4DCT scan sets were acquired for 20 patients who underwent EB-PBI. For each patient a conventional 3D conformal plan (3D-CRT) was generated based on end-inhalation phase (EI). The treatment plan based on the 4DCT EI phase images was copied and applied to the end-exhalation phase (EE) and 3DCT images (defined as EB-PBI(EI), EB-PBI(EE), EB-PBI(3D), respectively)...
April 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28462689/intensity-modulated-radiation-therapy-improves-the-target-coverage-over-3-d-planning-while-meeting-lung-tolerance-doses-for-all-patients-with-malignant-pleural-mesothelioma
#11
Sukran Ulger, Eren Cetin, Serap Catli, Hilal Sarac, Diclehan Kilic, Huseyin Bora
PURPOSE: To investigate high conformality on target coverage and the ability on creating strict lung dose limitation of intensity-modulated radiation therapy in malignant pleural mesothelioma. PATIENTS AND METHODS: Twenty-four radiation therapy plannings were evaluated and compared with dosimetric outcomes of conformal radiation therapy and intensity-modulated radiation therapy. Hemithoracal radiation therapy was performed on 12 patients with a fraction of 1.8 Gy to a total dose of 50...
June 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28357632/radiotherapy-for-adrenal-gland-metastases-from-hepatocellular-carcinoma
#12
B-Y Yuan, Y Hu, L Zhang, Y-H Chen, Y-Y Dong, Z-C Zeng
BACKGROUND: Several studies have found benefits of radiotherapy for adrenal metastasis from hepatocellular carcinoma (HCC). However, the efficacy, safety and outcome issues have not yet been fully addressed. Therefore, we performed this study to further elucidate the feasibility and outcome of radiotherapy in treating adrenal metastasis from HCC. METHODS: We retrospectively analyzed 81 patients with adrenal metastasis from HCC between 2001 and 2015. Eighteen patients received helical tomotherapy and 63 patients received conventional radiotherapy, including two-dimensional (2-D) or three-dimensional conformal radiotherapy (3-D CRT)...
September 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28341225/improved-outcomes-with-modern-lung-sparing-trimodality-therapy-in-patients-with-malignant-pleural-mesothelioma
#13
Fauzia Shaikh, Marjorie G Zauderer, Donata von Reibnitz, Abraham J Wu, Ellen D Yorke, Amanda Foster, Weiji Shi, Zhigang Zhang, Prasad S Adusumilli, Kenneth E Rosenzweig, Lee M Krug, Valerie W Rusch, Andreas Rimner
INTRODUCTION: Higher target conformity and better sparing of organs at risk with modern radiotherapy (RT) may result in higher tumor control and less toxicity. In this study, we compare our institutional multimodality therapy experience of adjuvant chemotherapy and hemithoracic intensity-modulated pleural RT (IMPRINT) with previously used adjuvant conventional RT (CONV) in patients with malignant pleural mesothelioma (MPM) treated with lung-sparing pleurectomy/decortication (P/D)...
June 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28318880/highly-conformal-craniospinal-radiotherapy-techniques-can-underdose-the-cranial-clinical-target-volume-if-leptomeningeal-extension-through-skull-base-exit-foramina-is-not-contoured
#14
D J Noble, T Ajithkumar, J Lambert, I Gleeson, M V Williams, S J Jefferies
AIMS: Craniospinal irradiation (CSI) remains a crucial treatment for patients with medulloblastoma. There is uncertainty about how to manage meningeal surfaces and cerebrospinal fluid (CSF) that follows cranial nerves exiting skull base foramina. The purpose of this study was to assess plan quality and dose coverage of posterior cranial fossa foramina with both photon and proton therapy. MATERIALS AND METHODS: We analysed the radiotherapy plans of seven patients treated with CSI for medulloblastoma and primitive neuro-ectodermal tumours and three with ependymoma (total n = 10)...
July 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28297441/comprehensive-dosimetric-planning-comparison-for-early-stage-non-small-cell-lung-cancer-with-sabr-fixed-beam-imrt-versus-vmat-versus-tomotherapy
#15
Ilma Xhaferllari, Omar El-Sherif, Stewart Gaede
Volumetric-modulated arc therapy (VMAT) is emerging as a leading technology in treating early-stage, non-small cell lung cancer (NSCLC) with stereotactic ablative radiotherapy (SABR). However, two other modalities capable of delivering intensity-modulated radiation therapy (IMRT) include fixed-beam and helical TomoTherapy (HT). This study aims to provide an extensive dosimetric comparison among these various IMRT techniques for treating early-stage NSCLC with SABR. Ten early-stage NSCLC patients were retrospectively optimized using three fixed-beam techniques via nine to eleven beams (high and low modulation step-and-shoot (SS), and sliding window (SW)), two VMAT techniques via two partial arcs (SmartArc (SA) and RapidArc (RA)), and three HT techniques via three different fan beam widths (1 cm, 2...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28255809/unplanned-irradiation-of-internal-mammary-lymph-nodes-in-breast-cancer
#16
Gul Kanyilmaz, Meryem Aktan, Mehmet Koc, Hikmettin Demir, Lütfi Saltuk Demir
AIMS: To evaluate the incidental dose to the internal mammary chain (IMC) in patients treated with three-dimensional conformal radiotherapy, to estimate the predictors affecting the magnitude of IMC receiving dose and to determine the predictive role of clinical parameters on survival. MATERIALS AND METHODS: Between 2009 and 2015, 348 patients undergoing RT for breast cancer were retrospectively analyzed. All patients underwent our department's routine procedure for breast cancer...
June 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28224401/synchronous-bilateral-breast-cancer-irradiation-clinical-and-dosimetrical-issues-using-volumetric-modulated-arc-therapy-and-simultaneous-integrated-boost
#17
Alba Fiorentino, Rosario Mazzola, Stefania Naccarato, Niccolò Giaj-Levra, Sergio Fersino, Gianluisa Sicignano, Umberto Tebano, Francesco Ricchetti, Ruggero Ruggieri, Filippo Alongi
OBJECTIVES: The aim of the present retrospective analysis was to evaluate dosimetric parameters, feasibility and outcome for Synchronous Bilateral Breast Cancer (SBBC) patients treated with adjuvant radiotherapy (RT) by Volumetric Modulated Arc Therapy (VMAT). METHODS: From September 2011 to April 2016, 1100 Breast Cancer (BC) patients were referred to our institution to receive adjuvant breast RT, and those with SBBC were selected for the present analysis. A total of 16 patients were identified...
June 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28211638/the-relationship-between-ovarian-function-and-ovarian-limited-dose-in-radiotherapy-postoperation-of-ovarian-transposition-in-young-patients-with-cervical-cancer
#18
Zhenhua Du, Hui Qu
In this study, the relationship between ovarian function and ovarian limited dose in radiotherapy was evaluated in young patients with cervical cancer who underwent ovarian transposition (Fig1B). Moreover, the novel ovarian dose limit for a better preservation of ovarian function in intensity-modulated radiation therapy (IMRT) was determined. We retrospectively analyzed data from 86 patients with cervical cancer who received radical hysterectomy and ovarian transposition from January 2013 to June 2015. In agreement with the National Comprehensive Cancer Network Guidelines (NCCN) for Cervical Cancer Version 2...
March 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28203163/is-the-deep-inspiration-breath-hold-technique-superior-to-the-free-breathing-technique-in-cardiac-and-lung-sparing-while-treating-both-left-sided-post-mastectomy-chest-wall-and-supraclavicular-regions
#19
Anupama Darapu, Rajesh Balakrishnan, Patricia Sebastian, Mohamathu Rafic Kather Hussain, Paul Ravindran, Subhashini John
AIMS: To evaluate the efficacy of the deep inspirational breath-hold (DIBH) technique and its dosimetric advantages over the free breathing (FB) technique in cardiac (heart and left anterior descending artery [LAD]) and ipsilateral lung sparing in left-sided post-mastectomy field-in-field conformal radiotherapy. DIBH is highly reproducible, and this study aims to find out its dosimetric benefits over FB. MATERIALS AND METHODS: Nineteen left-sided mastectomy patients were immobilized using breast boards with both arms positioned above the head...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28048366/su-f-t-632-on-the-use-of-intensity-modulated-arc-therapy-for-thoracic-vertebral-metastases-sbrt-treatment
#20
D Pokhrel, M Mallory, R Badkul, H Jiang, H Saleh, F Wang, C Lominska
PURPOSE: To retrospectively evaluate quality, efficiency and delivery accuracy of intensity modulated arc therapy (IMAT) plans for thoracic-vertebral metastases using stereotactic body radiotherapy (SBRT). METHODS: After obtaining approval of RPC-benchmark plan, seven previously treated thoracic-vertebral metastases patients with non-coplanar hybrid arcs(NC-HA)using 1-2 3D-dynamic conformal partial-arcs plus 7-9 IMRT-beams were re-optimized with IMAT using 3 full co-planar arcs...
June 2016: Medical Physics
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