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Inverse Planning

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https://www.readbyqxmd.com/read/29772065/isodose-feature-preserving-voxelization-ifpv-for-radiation-therapy-treatment-planning
#1
Hongcheng Liu, Lei Xing
PURPOSE: Inverse planning involves iterative optimization of a large number of parameters and is known to be a labor-intensive procedure. To reduce the scale of computation and improve characterization of isodose plan, this paper presents an isodose feature-preserving voxelization (IFPV) framework for radiation therapy applications and demonstrate an implementation of inverse planning in the IFPV domain. METHODS: A dose distribution in IFPV scheme is characterized by partitioning the voxels into subgroups according to their geometric and dosimetric values...
May 17, 2018: Medical Physics
https://www.readbyqxmd.com/read/29766770/mri-guided-thrombolysis-for-stroke-with-unknown-time-of-onset
#2
Götz Thomalla, Claus Z Simonsen, Florent Boutitie, Grethe Andersen, Yves Berthezene, Bastian Cheng, Bharath Cheripelli, Tae-Hee Cho, Franz Fazekas, Jens Fiehler, Ian Ford, Ivana Galinovic, Susanne Gellissen, Amir Golsari, Johannes Gregori, Matthias Günther, Jorge Guibernau, Karl Georg Häusler, Michael Hennerici, André Kemmling, Jacob Marstrand, Boris Modrau, Lars Neeb, Natalia Perez de la Ossa, Josep Puig, Peter Ringleb, Pascal Roy, Enno Scheel, Wouter Schonewille, Joaquin Serena, Stefan Sunaert, Kersten Villringer, Anke Wouters, Vincent Thijs, Martin Ebinger, Matthias Endres, Jochen B Fiebach, Robin Lemmens, Keith W Muir, Norbert Nighoghossian, Salvador Pedraza, Christian Gerloff
Background Under current guidelines, intravenous thrombolysis is used to treat acute stroke only if it can be ascertained that the time since the onset of symptoms was less than 4.5 hours. We sought to determine whether patients with stroke with an unknown time of onset and features suggesting recent cerebral infarction on magnetic resonance imaging (MRI) would benefit from thrombolysis with the use of intravenous alteplase. Methods In a multicenter trial, we randomly assigned patients who had an unknown time of onset of stroke to receive either intravenous alteplase or placebo...
May 16, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29762322/maternal-folic-acid-supplementation-and-the-risk-of-oral-clefts-in-offspring
#3
Arezoo Jahanbin, Elaheh Shadkam, Hamid Heidarian Miri, Alireza Sarraf Shirazi, Mostafa Abtahi
INTRODUCTION: There is controversial evidence from the literature regarding the protective effect of folic acid supplementation during pregnancy against orofacial clefts. The authors undertook this meta-analysis to assess whether folate supplementation during pregnancy can reduce the risk of nonsyndromic cleft lip with or without cleft palate (CL/P) and cleft palate only (CPO) in infants. METHODS: Eligible articles were identified by searching databases, including PubMed, Medline, Scopus, ISI (Web of Knowledge) to September 2017...
May 14, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29752852/prognostic-significance-of-elevated-serum-cd44-levels-in-patients-with-oral-squamous-cell-carcinoma
#4
Sharada Sawant, Chetan Ahire, Harsh Dongre, Shriya Joshi, Sayli Jamghare, Pallavi Rane, Shubhada Kane, Devendra Chaukar
BACKGROUND: Availability of reliable methods distinguishing high risk recurrent tumours from regressive tumours prior to surgery could help in better management of the disease. Present study was aimed to estimate pre-surgical serum CD44 concentration and assess the possibility of using it as a non-invasive prognostic tool in oral cancer. METHODS: ELISA was performed on pre-surgical serum samples from 64 primary oral cancer patients and 16 healthy individuals to estimate soluble CD44 levels...
May 12, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29742656/satisfaction-with-the-intrauterine-device-insertion-procedure-among-adolescent-and-young-adult-women
#5
Aletha Y Akers, Jennifer Harding, Lisa K Perriera, Courtney Schreiber, J Felipe Garcia-Espana, Sarita Sonalkar
OBJECTIVE: To evaluate satisfaction with intrauterine device (IUD) insertion procedures among adolescent and young adult women. METHODS: This secondary analysis of data from a multisite, single-blind, sham-controlled randomized trial of women having a levonorgestrel 13.5-mg IUD inserted enrolled participants from March 2015 through July 2016 at three family planning clinics in Philadelphia, Pennsylvania. Eligible participants were 14-22 years of age, nulliparous, not pregnant, and English-speaking...
May 7, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29732441/quantitative-oct-angiography-evaluation-of-peripapillary-retinal-circulation-after-plaque-brachytherapy
#6
Alison H Skalet, Liang Liu, Christina Binder, Audra K Miller, Jie Wang, David J Wilson, Richard Crilly, Charles R Thomas, Arthur Y Hung, David Huang, Yali Jia
Objective: To study peripapillary retinal capillary circulation in eyes treated with I-125 plaque brachytherapy for uveal melanoma using optical coherence tomography angiography (OCTA). Design: Cross-sectional study of 10 subjects imaged with OCTA prior to uveal melanoma treatment and 15 subjects imaged after development of radiation retinopathy and/or optic neuropathy. Participants: Following IRB approval, subjects were enrolled from an academic ocular oncology clinical practice...
March 2018: Ophthalmology retina
https://www.readbyqxmd.com/read/29730279/utilizing-18f-fluoroethyltyrosine-fet-positron-emission-tomography-pet-to-define-suspected-nonenhancing-tumor-for-radiation-therapy-planning-of-glioblastoma
#7
Aimee R Hayes, Dasantha Jayamanne, Edward Hsiao, Geoffrey P Schembri, Dale L Bailey, Paul J Roach, Mustafa Khasraw, Allison Newey, Helen R Wheeler, Michael Back
AIM: The authors sought to evaluate the impact of 18F-fluoroethyltyrosine (FET) positron emission tomography (PET) on radiation therapy planning for patients diagnosed with glioblastoma (GBM) and the presence of suspected nonenhancing tumors compared with standard magnetic resonance imaging (MRI). METHODS AND MATERIALS: Patients with GBM and contrast-enhanced MRI scans showing regions suspicious of nonenhancing tumor underwent postoperative FET-PET before commencing radiation therapy...
January 31, 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29726361/a-randomized-trial-of-mometasone-furoate-0-1-to-reduce-high-grade-acute-radiation-dermatitis-in-breast-cancer-patients-receiving-postmastectomy-radiation
#8
Alice Y Ho, Molly Olm-Shipman, Zhigang Zhang, Chun Ting Siu, Molly Wilgucki, Anh Phung, Brittany B Arnold, Marypat Porinchak, Mario Lacouture, Beryl McCormick, Simon N Powell, Daphna Y Gelblum
PURPOSE: A 2-arm, double-blinded randomized trial was conducted to evaluate the efficacy of 0.1% mometasone furoate (MF) versus Eucerin Original (E) cream in preventing the development of moderate to severe acute radiation dermatitis (ARD) in breast cancer patients receiving postmastectomy radiation (PMRT). METHODS: Breast cancer patients undergoing chest wall with or without nodal radiation therapy (RT) (50 Gy) were eligible. Randomization (1:1) was to MF or E, applied twice daily from day 1 of PMRT to 14 days after PMRT...
June 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29697493/performance-of-an-automated-versus-a-manual-whole-body-magnetic-resonance-imaging-workflow
#9
Daniel Stocker, Tim Finkenstaedt, Bernd Kuehn, Daniel Nanz, Markus Klarhoefer, Roman Guggenberger, Gustav Andreisek, Berthold Kiefer, Caecilia S Reiner
OBJECTIVES: The aim of this study was to evaluate the performance of an automated workflow for whole-body magnetic resonance imaging (WB-MRI), which reduces user interaction compared with the manual WB-MRI workflow. MATERIALS AND METHODS: This prospective study was approved by the local ethics committee. Twenty patients underwent WB-MRI for myopathy evaluation on a 3 T MRI scanner. Ten patients (7 women; age, 52 ± 13 years; body weight, 69.9 ± 13.3 kg; height, 173 ± 9...
April 24, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29695565/patient-height-weight-bmi-and-age-as-predictors-of-gracilis-muscle-free-flap-mass-in-lower-extremity-reconstruction
#10
Carlo M Oranges, Mathias Tremp, Wenjin Wang, Srinivas Madduri, Pietro G DI Summa, Reto Wettstein, Dirk J Schaefer, Daniel F Kalbermatten
BACKGROUND: Gracilis muscle flap is commonly used for the reconstruction of defects of the lower extremities. Preoperative evaluation of gracilis muscle dimension is a key aspect in surgical planning. This study aimed to determine whether patient height, weight, body mass index (BMI) and age are reliable proxy measurements of the mass of gracilis muscle flap. PATIENTS AND METHODS: Twenty-two patients treated for lower extremity reconstruction with free gracilis flap between December 2010 and December 2014 were considered...
May 2018: In Vivo
https://www.readbyqxmd.com/read/29694292/the-effect-of-plan-type-and-comprehensive-medication-reviews-on-high-risk-medication-use
#11
Armando Silva Almodovar, David Rhys Axon, Ashley M Coleman, Terri Warholak, Milap C Nahata
BACKGROUND: In 2007, the Centers for Medicare & Medicaid Services (CMS) instituted a star rating system using performance outcome measures to assess Medicare Advantage Prescription Drug (MAPD) and Prescription Drug Plan (PDP) providers. OBJECTIVE: To assess the relationship between 2 performance outcome measures for Medicare insurance providers, comprehensive medication reviews (CMRs), and high-risk medication use. METHODS: This cross-sectional study included Medicare Part C and Part D performance data from the 2014 and 2015 calendar years...
May 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29687743/clinical-outcomes-of-treatment-with-filgrastim-versus-a-filgrastim-biosimilar-and-febrile-neutropenia-associated-costs-among-patients-with-nonmyeloid-cancer-undergoing-chemotherapy
#12
Lee S Schwartzberg, Lincy S Lal, Sanjeev Balu, Kim Campbell, Lee Brekke, Andrew DeLeon, Caitlin Elliott, Stephanie Korrer
BACKGROUND: Granulocyte colony-stimulating factors such as filgrastim are used to decrease the incidence of febrile neutropenia (FN) among patients with nonmyeloid cancers undergoing chemotherapy treatment. Although the biosimilar filgrastim-sndz has been approved in the United States since 2015, limited real-world comparisons of filgrastim-sndz versus reference filgrastim (filgrastim-ref) have been conducted. OBJECTIVE: To compare FN incidence and assess overall FN-related health care resource utilization and medical costs among U...
April 24, 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29685458/prevalence-of-drug-resistant-tuberculosis-and-imputed-burden-in-south-africa-a-national-and-sub-national-cross-sectional-survey
#13
Nazir Ahmed Ismail, Lindiwe Mvusi, Ananta Nanoo, Andries Dreyer, Shaheed V Omar, Sanni Babatunde, Thabo Molebatsi, Martie van der Walt, Adeboye Adelekan, Varough Deyde, Chikwe Ihekweazu, Shabir A Madhi
BACKGROUND: Globally, per-capita, South Africa reports a disproportionately high number of cases of multidrug-resistant (MDR) tuberculosis and extensively drug-resistant (XDR) tuberculosis. We sought to estimate the prevalence of resistance to tuberculosis drugs in newly diagnosed and retreated patients with tuberculosis provincially and nationally, and compared these with the 2001-02 estimates. METHODS: A cross-sectional survey was done between June 15, 2012-June 14, 2014, using population proportionate randomised cluster sampling in the nine provinces in South Africa...
April 20, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29682029/meningioma-consistency-correlation-between-magnetic-resonance-imaging-characteristics-operative-findings-and-histopathological-features
#14
Mahmoud Alyamany, Mohammad M Alshardan, Abdullah Abu Jamea, Nahid ElBakry, Lahbib Soualmi, Yasser Orz
Introduction: Intracranial meningiomas account for 30% of all primary intracranial tumors. Surgical resection remains the mainstay of the treatment for meningiomas. The magnetic resonance of intracranial meningiomas has been largely discussed in many reports of the radiological and neurosurgical literature. To date, a few studies have been attempted to differentiate the tumor characteristics of meningiomas based on magnetic resonance imaging (MRI) studies. Objective: The objective of the study is to evaluate the relationship between MRI signal characteristics of intracranial meningiomas and consistency of tumor using objective measures...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29681602/-dose-distribution-optimization-in-combined-intracavitary-and-interstitial-brachytherapy-for-cervical-cancer
#15
Daisuke Ozaki, Makoto Miyazawa, Youji Habano, Motohiro Kawashima, Yoshihiko Hoshino, Takayuki Sutou
PURPOSE: Hybrid inverse treatment planning optimization (HIPO) is a new optimization tool for brachytherapy. We verified its utility using treatment plans for combined intracavitary and interstitial brachytherapy in cervical cancer. MATERIALS & METHODS: We compared the manually optimized plan and the plan optimized using HIPO. The plan using HIPO was optimized with three different methods: needle only, tandem and needle, and all applicators. The dose volume histogram (DVH) parameters such as D90 of high risk clinical target volume (HR-CTV) and D2cc of OAR (rectum, sigmoid colon and bladder) were used to evaluate each treatment plan...
2018: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/29679492/knowledge-based-automated-planning-for-oropharyngeal-cancer
#16
Aaron Babier, Justin J Boutilier, Andrea L McNiven, Timothy C Y Chan
PURPOSE: To automatically generate radiation therapy plans for oropharynx patients by com-bining knowledge-based planning (KBP) predictions with an inverse optimization (IO) pipeline. METHODS: We developed two KBP approaches, the bagging query (BQ) method and the generalized principal component analysis-based (gPCA) method, to predict achievable dose volume histograms (DVHs). These approaches generalize existing methods by predicting physically feasible organ-at-risk (OAR) and target DVHs in sites with multiple targets...
April 21, 2018: Medical Physics
https://www.readbyqxmd.com/read/29673122/native-myocardial-t1-time-can-predict-development-of-subsequent-anthracycline-induced-cardiomyopathy
#17
Fabian Muehlberg, Stephanie Funk, Leonora Zange, Florian von Knobelsdorff-Brenkenhoff, Edyta Blaszczyk, Alexander Schulz, Saeed Ghani, Annete Reichardt, Peter Reichardt, Jeanette Schulz-Menger
AIMS: This study aims to assess subclinical changes in functional and morphological myocardial magnetic resonance parameters very early into an anthracycline treatment, which may predict subsequent development of anthracycline-induced cardiomyopathy (aCMP). METHODS AND RESULTS: Thirty sarcoma patients with planned anthracycline-based chemotherapy (360-400 mg/m2 doxorubicin-equivalent) were recruited. Median treatment time was 19.1 ± 2.1 weeks. Enrolled individuals received three cardiovascular magnetic resonance studies (before treatment, 48 h after first anthracycline treatment, and upon completion of treatment)...
April 19, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29671199/automatic-planning-of-needle-placement-for-robot-assisted-percutaneous-procedures
#18
Esia Belbachir, Ehsan Golkar, Bernard Bayle, Caroline Essert
PURPOSE: Percutaneous procedures allow interventional radiologists to perform diagnoses or treatments guided by an imaging device, typically a computed tomography (CT) scanner with a high spatial resolution. To reduce exposure to radiations and improve accuracy, robotic assistance to needle insertion is considered in the case of X-ray guided procedures. We introduce a planning algorithm that computes a needle placement compatible with both the patient's anatomy and the accessibility of the robot within the scanner gantry...
April 18, 2018: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29663182/do-reciprocal-relationships-between-academic-workload-and-self-regulated-learning-predict-medical-freshmen-s-achievement-a-longitudinal-study-on-the-educational-transition-from-secondary-school-to-medical-school
#19
Joselina Barbosa, Álvaro Silva, Maria Amélia Ferreira, Milton Severo
One of the most important factors that makes the transition from secondary school to medical school challenging is the inability to put in the study time that a medical school curriculum demands. The implementation of regulated learning is essential for students to cope with medical course environment and succeed. This study aimed to investigate the reciprocal relationships between self-regulated learning skills (SRLS) and academic workload (AW) across secondary school to medical school transition. Freshmen enrolled in medical school (N = 102) completed questionnaires at the beginning and at the end of their academic year, assessing AW (measured as study time hours and perceived workload), SRLS (planning and strategies for learning assessment, motivation and action to learning and self-directedness) and academic achievement...
April 16, 2018: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/29658827/finite-element-method-based-kinematics-and-closed-loop-control-of-soft-continuum-manipulators
#20
Thor Morales Bieze, Frederick Largilliere, Alexandre Kruszewski, Zhongkai Zhang, Rochdi Merzouki, Christian Duriez
This article presents a modeling methodology and experimental validation for soft manipulators to obtain forward kinematic model (FKM) and inverse kinematic model (IKM) under quasi-static conditions (in the literature, these manipulators are usually classified as continuum robots. However, their main characteristic of interest in this article is that they create motion by deformation, as opposed to the classical use of articulations). It offers a way to obtain the kinematic characteristics of this type of soft robots that is suitable for offline path planning and position control...
April 16, 2018: Soft Robotics
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