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Inverse Planning

C Grassberger, H Paganetti
The variety of treatment options for cancer patients has increased significantly in recent years. Not only do we combine radiation with surgery and chemotherapy, new therapeutic approaches such as immunotherapy and targeted therapies are starting to play a bigger role. Physics has made significant contributions to radiation therapy treatment planning and delivery. In particular, treatment plan optimization using inverse planning techniques has improved dose conformity considerably. Furthermore, medical physics is often the driving force behind tumor control and normal tissue complication modeling...
October 19, 2016: Physics in Medicine and Biology
Amy J Davis, Mevin B Hooten, Ryan S Miller, Matthew L Farnsworth, Jesse Lewis, Michael Moxcey, Kim M Pepin
Evaluation of the progress of management programs for invasive species is crucial for demonstrating impacts to stakeholders and strategic planning of resource allocation. Estimates of abundance before and after management activities can serve as a useful metric of population management programs. However, many methods of estimating population size are too labor intensive and costly to implement, posing restrictive levels of burden on operational programs. Removal models are a reliable method for estimating abundance before and after management using data from the removal activities exclusively, thus requiring no work in addition to management...
October 2016: Ecological Applications: a Publication of the Ecological Society of America
Linlu Zhao, Darren M Roffey, Suzan Chen
STUDY DESIGN: Systematic review and meta-analysis. OBJECTIVE: To assess and synthesize the current evidence on the association between the rs1256120 single nucleotide polymorphism (SNP) of the estrogen receptor beta gene (ESR2) and adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA: Hormonal disturbance has been postulated as a potential etiological factor in the development of AIS. As estrogen receptors are important mediators of estrogen response, mutations in these genes, including rs1256120 of ESR2, have been chosen as susceptibility candidates for AIS predisposition...
October 17, 2016: Spine
Vinay V Kumar, P C Jacob, Vikram Kekatpure, Naveen Hedne, Felix P Koch, Moni A Kuriakose
AIM: The aim of this clinical paper is to introduce a technique to plan for functional maxillofacial reconstructions. MATERIALS AND METHODS: Preoperative dental casts were made of the patient and mock surgery performed on the casts. A fibula analogue was then placed in an ideal functional reconstruction position. New dentures were fabricated on the fibula analogue and drill holes for the placement of implants were placed through the denture. This denture formed as a guide to position the fibula transplant during surgery...
September 2016: Journal of Maxillofacial and Oral Surgery
Jenna Dean, Carmen J Hansen, Justin Westhuyzen, Brett Waller, Kirsty Turnbull, Maree Wood, Andrew Last
INTRODUCTION: Inverse-planned intensity modulated radiation therapy (IP-IMRT) has potential benefits over other techniques for tangential intact breast radiotherapy. Possible benefits include increased homogeneity, faster planning time, less inter-planner variability and lower doses to organs at risk (OAR). We therefore conducted a pilot study of previously treated intact breast patients to compare the current forward-planned 'field-in-field' technique (FP-IMRT) with an IP-IMRT alternative...
July 18, 2016: Journal of Medical Radiation Sciences
Susan Enguidanos, Jennifer Ailshire
CONTEXT: Given recent Medicare rules reimbursing clinicians for engaging in advance care planning, there is heightened need to understand factors associated with the timing of advance directive (AD) completion before death and how the timing impacts care decisions. OBJECTIVE: The purpose of this study is to investigate patterns in timing of AD completion and the relationship between timing and documented care preferences. We hypothesize that ADs completed late in the course of illness or very early in the disease trajectory will reflect higher preferences for aggressive care...
October 5, 2016: Journal of Pain and Symptom Management
Julian Steitz, Patrick Naumann, Silke Ulrich, Matthias F Haefner, Florian Sterzing, Uwe Oelfke, Mark Bangert
INTRODUCTION: The efficacy of radiation therapy treatments for pancreatic cancer is compromised by abdominal motion which limits the spatial accuracy for dose delivery - especially for particles. In this work we investigate the potential of worst case optimization for interfractional offline motion mitigation in carbon ion treatments of pancreatic cancer. METHODS: We implement a worst case optimization algorithm that explicitly models the relative biological effectiveness of carbon ions during inverse planning...
October 7, 2016: Radiation Oncology
Tapan Kumar Roy, Brijesh P Singh
BACKGROUND: Unwanted birth is an important public health concern due to its negative association with adverse outcomes of mothers and children as well as socioeconomic development of a country. Although a number of studies have been investigated the determinants of unwanted births through logistic regression analysis, an extensive assessment using path model is lacking. In the current study, we applied path analysis to know the important covariates for unwanted births in Bangladesh. METHODS: The study used data extracted from Bangladesh Demographic and Health Survey (BDHS) 2011...
2016: PloS One
Rajendra Karkee, Andy H Lee
BACKGROUND: Optimal birth spacing has health advantages for both mother and child. In developing countries, shorter birth intervals are common and associated with social, cultural, and economic factors, as well as a lack of family planning. This study investigated the first birth interval after marriage and preceding interbirth interval in Nepal. METHODS: A community-based prospective cohort study was conducted in the Kaski district of Nepal. Information on birth spacing, demographic, and obstetric characteristics was obtained from 701 pregnant women using a structured questionnaire...
2016: Frontiers in Public Health
Ivaylo B Mihaylov
PURPOSE: Medical images are more than pictures. They contain additional quantitative information which can be interrogated, quantified, and utilized. Besides anatomical information computed tomography (CT) imaging data provide electron density information. Radiotherapy use of this density information is limited to its application only in dose calculations. The direct product of dose, density, and volume forms a quantity called integral dose. The integral dose delivered to a volume of interest is the total energy deposited in that volume...
September 27, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Juan Antonio Llompart-Pou, Mario Chico-Fernández, Marcelino Sánchez-Casado, Fermín Alberdi-Odriozola, Francisco Guerrero-López, María Dolores Mayor-García, Javier González-Robledo, María Ángeles Ballesteros-Sanz, Rubén Herrán-Monge, Rafael León-López, Lucía López-Amor, Ana Bueno-González
BACKGROUND: Injury patterns may differ in trauma patients when age is considered. This information is relevant in the management of trauma patients and for planning preventive measures. METHODS: We included in the study all patients admitted for traumatic disease in the participating ICUs from November 23(rd), 2012 to July 31(st), 2015 with complete records. Data on epidemiology, injury patterns, severity scores, acute management, resources utilisation and outcome were recorded and compared in the following groups of age: ≤55years (young adults), 56-65 years (adults), 66-75 years (elderly), >75years (very elderly)...
September 2016: Injury
Taiki Magome, Jerry Froelich, Yutaka Takahashi, Luke Arentsen, Shernan Holtan, Michael R Verneris, Keenan Brown, Akihiro Haga, Keiichi Nakagawa, Jennifer L Holter Chakrabarty, Sebastian Giebel, Jeffrey Wong, Kathryn Dusenbery, Guy Storme, Susanta K Hui
PURPOSE: To develop an imaging method to characterize and map marrow composition in the entire skeletal system, and to simulate differential targeted marrow irradiation based on marrow composition. METHODS AND MATERIALS: Whole-body dual energy computed tomography (DECT) images of cadavers and leukemia patients were acquired, segmented to separate bone marrow components, namely, bone, red marrow (RM), and yellow marrow (YM). DECT-derived marrow fat fraction was validated using histology of lumbar vertebrae obtained from cadavers...
November 1, 2016: International Journal of Radiation Oncology, Biology, Physics
C V Guthier, A L Damato, A N Viswanathan, J Hesser, R A Cormack
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
H Liu, P Dong, L Xing
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
H Wang, L Xing
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
S K Ahmed, J J Kruse, C Beltran, N N Laack
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
M Mardani, P Dong, L Xing
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
R Yaparpalvi, K J Mehta, S C Desai, H C Kuo, W A Tome, S Kalnicki
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Muhammad Isa Khan, Runqing Jiang, Alexander Kiciak, Jalil Ur Rehman, Muhammad Afzal, James C L Chow
This study reviewed prostate volumetric-modulated arc therapy (VMAT) plans with intensity-modulated radiotherapy (IMRT) plans after prostate IMRT technique was replaced by VMAT in an institution. Characterizations of dosimetry and radiobiological variation in prostate were determined based on treatment plans of 40 prostate IMRT patients (planning target volume = 77.8-335 cm(3)) and 50 VMAT patients (planning target volume = 120-351 cm(3)) treated before and after 2013, respectively. Both IMRT and VMAT plans used the same dose-volume criteria in the inverse planning optimization...
July 2016: Journal of Medical Physics
Xuechao Duan, Yongzhi Yang, Bi Cheng
The kinematics of a two rotational degrees-of-freedom (DOF) spherical parallel manipulator (SPM) is developed based on the coordinate transformation approach and the cosine rule of a trihedral angle. The angular displacement, angular velocity, and angular acceleration between the actuators and end-effector are thus determined. Moreover, the dynamic model of the 2-DOF SPM is established by using the virtual work principle and the first-order influence coefficient matrix of the manipulator. Eventually, a typical motion plan and simulations are carried out, and the actuating torque needed for these motions are worked out by employing the derived inverse dynamic equations...
2016: Sensors
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