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https://www.readbyqxmd.com/read/28334068/the-dyslexia-susceptibility-protein-kiaa0319-inhibits-axon-growth-through-smad2-signaling
#1
Filipa Franquinho, Joana Nogueira-Rodrigues, Joana M Duarte, Sofia S Esteves, Christin Carter-Su, Anthony P Monaco, Zoltán Molnár, Antonio Velayos-Baeza, Pedro Brites, Mónica M Sousa
KIAA0319 is a transmembrane protein associated with dyslexia with a presumed role in neuronal migration. Here we show that KIAA0319 expression is not restricted to the brain but also occurs in sensory and spinal cord neurons, increasing from early postnatal stages to adulthood and being downregulated by injury. This suggested that KIAA0319 participates in functions unrelated to neuronal migration. Supporting this hypothesis, overexpression of KIAA0319 repressed axon growth in hippocampal and dorsal root ganglia neurons; the intracellular domain of KIAA0319 was sufficient to elicit this effect...
February 17, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28331430/measurement-of-the-production-cross-section-of-a-w%C3%A2-boson-in-association-with-two-b-jets-in-pp-collisions-at-formula-see-text
#2
V Khachatryan, A M Sirunyan, A Tumasyan, W Adam, E Asilar, T Bergauer, J Brandstetter, E Brondolin, M Dragicevic, J Erö, M Flechl, M Friedl, R Frühwirth, V M Ghete, C Hartl, N Hörmann, J Hrubec, M Jeitler, A König, I Krätschmer, D Liko, T Matsushita, I Mikulec, D Rabady, N Rad, B Rahbaran, H Rohringer, J Schieck, J Strauss, W Treberer-Treberspurg, W Waltenberger, C-E Wulz, V Mossolov, N Shumeiko, J Suarez Gonzalez, S Alderweireldt, E A De Wolf, X Janssen, J Lauwers, M Van De Klundert, H Van Haevermaet, P Van Mechelen, N Van Remortel, A Van Spilbeeck, S Abu Zeid, F Blekman, J D'Hondt, N Daci, I De Bruyn, K Deroover, N Heracleous, S Lowette, S Moortgat, L Moreels, A Olbrechts, Q Python, S Tavernier, W Van Doninck, P Van Mulders, I Van Parijs, H Brun, C Caillol, B Clerbaux, G De Lentdecker, H Delannoy, G Fasanella, L Favart, R Goldouzian, A Grebenyuk, G Karapostoli, T Lenzi, A Léonard, J Luetic, T Maerschalk, A Marinov, A Randle-Conde, T Seva, C Vander Velde, P Vanlaer, R Yonamine, F 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Tavolaro, K Theofilatos, R Wallny, T K Aarrestad, C Amsler, L Caminada, M F Canelli, A De Cosa, C Galloni, A Hinzmann, T Hreus, B Kilminster, C Lange, J Ngadiuba, D Pinna, G Rauco, P Robmann, D Salerno, Y Yang, V Candelise, T H Doan, Sh Jain, R Khurana, M Konyushikhin, C M Kuo, W Lin, Y J Lu, A Pozdnyakov, S S Yu, Arun Kumar, P Chang, Y H Chang, Y W Chang, Y Chao, K F Chen, P H Chen, C Dietz, F Fiori, W-S Hou, Y Hsiung, Y F Liu, R-S Lu, M Miñano Moya, E Paganis, A Psallidas, J F Tsai, Y M Tzeng, B Asavapibhop, G Singh, N Srimanobhas, N Suwonjandee, A Adiguzel, M N Bakirci, S Damarseckin, Z S Demiroglu, C Dozen, E Eskut, S Girgis, G Gokbulut, Y Guler, E Gurpinar, I Hos, E E Kangal, O Kara, U Kiminsu, M Oglakci, G Onengut, K Ozdemir, S Ozturk, A Polatoz, D Sunar Cerci, S Turkcapar, I S Zorbakir, C Zorbilmez, B Bilin, S Bilmis, B Isildak, G Karapinar, M Yalvac, M Zeyrek, E Gülmez, M Kaya, O Kaya, E A Yetkin, T Yetkin, A Cakir, K Cankocak, S Sen, B Grynyov, L Levchuk, P Sorokin, R Aggleton, F Ball, L Beck, J J Brooke, D Burns, E Clement, D Cussans, H Flacher, J Goldstein, M Grimes, G P Heath, H F Heath, J Jacob, L Kreczko, C Lucas, D M Newbold, S Paramesvaran, A Poll, T Sakuma, S Seif El Nasr-Storey, D Smith, V J Smith, K W Bell, A Belyaev, C Brew, R M Brown, L Calligaris, D Cieri, D J A Cockerill, J A Coughlan, K Harder, S Harper, E Olaiya, D Petyt, C H Shepherd-Themistocleous, A Thea, I R Tomalin, T Williams, M Baber, R Bainbridge, O Buchmuller, A Bundock, D Burton, S Casasso, M Citron, D Colling, L Corpe, P Dauncey, G Davies, A De Wit, M Della Negra, R Di Maria, P Dunne, A Elwood, D Futyan, Y Haddad, G Hall, G Iles, T James, R Lane, C Laner, R Lucas, L Lyons, A-M Magnan, S Malik, L Mastrolorenzo, J Nash, A Nikitenko, J Pela, B Penning, M Pesaresi, D M Raymond, A Richards, A Rose, C Seez, S Summers, A Tapper, K Uchida, M Vazquez Acosta, T Virdee, J Wright, S C Zenz, J E Cole, P R Hobson, A Khan, P Kyberd, D Leslie, I D Reid, P Symonds, L Teodorescu, M Turner, A Borzou, K Call, J Dittmann, K Hatakeyama, H Liu, N Pastika, O Charaf, S I Cooper, C Henderson, P Rumerio, D Arcaro, A Avetisyan, T Bose, D Gastler, D Rankin, C Richardson, J Rohlf, L Sulak, D Zou, G Benelli, E Berry, D Cutts, A Garabedian, J Hakala, U Heintz, J M Hogan, O Jesus, E Laird, G Landsberg, Z Mao, M Narain, S Piperov, S Sagir, E Spencer, R Syarif, R Breedon, G Breto, D Burns, M Calderon De La Barca Sanchez, S Chauhan, M Chertok, J Conway, R Conway, P T Cox, R Erbacher, C Flores, G Funk, M Gardner, W Ko, R Lander, C Mclean, M Mulhearn, D Pellett, J Pilot, F Ricci-Tam, S Shalhout, J Smith, M Squires, D Stolp, M Tripathi, S Wilbur, R Yohay, R Cousins, P Everaerts, A Florent, J Hauser, M Ignatenko, D Saltzberg, E Takasugi, V Valuev, M Weber, K Burt, R Clare, J Ellison, J W Gary, G Hanson, J Heilman, P Jandir, E Kennedy, F Lacroix, O R Long, M Malberti, M Olmedo Negrete, M I Paneva, A Shrinivas, H Wei, S Wimpenny, B R Yates, J G Branson, G B Cerati, S Cittolin, M Derdzinski, R Gerosa, A Holzner, D Klein, V Krutelyov, J Letts, I Macneill, D Olivito, S Padhi, M Pieri, M Sani, V Sharma, S Simon, M Tadel, A Vartak, S Wasserbaech, C Welke, J Wood, F Würthwein, A Yagil, G Zevi Della Porta, R Bhandari, J Bradmiller-Feld, C Campagnari, A Dishaw, V Dutta, K Flowers, M Franco Sevilla, P Geffert, C George, F Golf, L Gouskos, J Gran, R Heller, J Incandela, N Mccoll, S D Mullin, A Ovcharova, J Richman, D Stuart, I Suarez, C West, J Yoo, D Anderson, A Apresyan, J Bendavid, A Bornheim, J Bunn, Y Chen, J Duarte, J M Lawhorn, A Mott, H B Newman, C Pena, M Spiropulu, J R Vlimant, S Xie, R Y Zhu, M B Andrews, V Azzolini, B Carlson, T Ferguson, M Paulini, J Russ, M Sun, H Vogel, I Vorobiev, J P Cumalat, W T Ford, F Jensen, A Johnson, M Krohn, T Mulholland, K Stenson, S R Wagner, J Alexander, J Chaves, J Chu, S Dittmer, K Mcdermott, N Mirman, G Nicolas Kaufman, J R Patterson, A Rinkevicius, A Ryd, L Skinnari, L Soffi, S M Tan, Z Tao, J Thom, J Tucker, P Wittich, M Zientek, D Winn, S Abdullin, M Albrow, G Apollinari, S Banerjee, L A T Bauerdick, A Beretvas, J Berryhill, P C Bhat, G Bolla, K Burkett, J N Butler, H W K Cheung, F Chlebana, S Cihangir, M Cremonesi, V D Elvira, I Fisk, J Freeman, E Gottschalk, L Gray, D Green, S Grünendahl, O Gutsche, D Hare, R M Harris, S Hasegawa, J Hirschauer, Z Hu, B Jayatilaka, S Jindariani, M Johnson, U Joshi, B Klima, B Kreis, S Lammel, J Linacre, D Lincoln, R Lipton, T Liu, R Lopes De Sá, J Lykken, K Maeshima, N Magini, J M Marraffino, S Maruyama, D Mason, P McBride, P Merkel, S Mrenna, S Nahn, C Newman-Holmes, V O'Dell, K Pedro, O Prokofyev, G Rakness, L Ristori, E Sexton-Kennedy, A Soha, W J Spalding, L Spiegel, S Stoynev, N Strobbe, L Taylor, S Tkaczyk, N V Tran, L Uplegger, E W Vaandering, C Vernieri, M Verzocchi, R Vidal, M Wang, H A Weber, A Whitbeck, D Acosta, P Avery, P Bortignon, D Bourilkov, A Brinkerhoff, A Carnes, M Carver, D Curry, S Das, R D Field, I K Furic, J Konigsberg, A Korytov, P Ma, K Matchev, H Mei, P Milenovic, G Mitselmakher, D Rank, L Shchutska, D Sperka, L Thomas, J Wang, S Wang, J Yelton, S Linn, P Markowitz, G Martinez, J L Rodriguez, A Ackert, J R Adams, T Adams, A Askew, S Bein, B Diamond, S Hagopian, V Hagopian, K F Johnson, A Khatiwada, H Prosper, A Santra, M Weinberg, M M Baarmand, V Bhopatkar, S Colafranceschi, M Hohlmann, D Noonan, T Roy, F Yumiceva, M R Adams, L Apanasevich, D Berry, R R Betts, I Bucinskaite, R Cavanaugh, O Evdokimov, L Gauthier, C E Gerber, D J Hofman, P Kurt, C O'Brien, I D Sandoval Gonzalez, P Turner, N Varelas, H Wang, Z Wu, M Zakaria, J Zhang, B Bilki, W Clarida, K Dilsiz, S Durgut, R P Gandrajula, M Haytmyradov, V Khristenko, J-P Merlo, H Mermerkaya, A Mestvirishvili, A Moeller, J Nachtman, H Ogul, Y Onel, F Ozok, A Penzo, C Snyder, E Tiras, J Wetzel, K Yi, I Anderson, B Blumenfeld, A Cocoros, N Eminizer, D Fehling, L Feng, A V Gritsan, P Maksimovic, M Osherson, J Roskes, U Sarica, M Swartz, M Xiao, Y Xin, C You, A Al-Bataineh, P Baringer, A Bean, J Bowen, C Bruner, J Castle, R P Kenny Iii, A Kropivnitskaya, D Majumder, W Mcbrayer, M Murray, S Sanders, R Stringer, J D Tapia Takaki, Q Wang, A Ivanov, K Kaadze, S Khalil, M Makouski, Y Maravin, A Mohammadi, L K Saini, N Skhirtladze, S Toda, D Lange, F Rebassoo, D Wright, C Anelli, A Baden, O Baron, A Belloni, B Calvert, S C Eno, C Ferraioli, J A Gomez, N J Hadley, S Jabeen, R G Kellogg, T Kolberg, J Kunkle, Y Lu, A C Mignerey, Y H Shin, A Skuja, M B Tonjes, S C Tonwar, D Abercrombie, B Allen, A Apyan, R Barbieri, A Baty, R Bi, K Bierwagen, S Brandt, W Busza, I A Cali, Z Demiragli, L Di Matteo, G Gomez Ceballos, M Goncharov, D Hsu, Y Iiyama, G M Innocenti, M Klute, D Kovalskyi, K Krajczar, Y S Lai, Y-J Lee, A Levin, P D Luckey, A C Marini, C Mcginn, C Mironov, S Narayanan, X Niu, C Paus, C Roland, G Roland, J Salfeld-Nebgen, G S F Stephans, K Sumorok, K Tatar, M Varma, D Velicanu, J Veverka, J Wang, T W Wang, B Wyslouch, M Yang, V Zhukova, A C Benvenuti, R M Chatterjee, A Evans, A Finkel, A Gude, P Hansen, S Kalafut, S C Kao, Y Kubota, Z Lesko, J Mans, S Nourbakhsh, N Ruckstuhl, R Rusack, N Tambe, J Turkewitz, J G Acosta, S Oliveros, E Avdeeva, R Bartek, K Bloom, S Bose, D R Claes, A Dominguez, C Fangmeier, R Gonzalez Suarez, R Kamalieddin, D Knowlton, I Kravchenko, A Malta Rodrigues, F Meier, J Monroy, J E Siado, G R Snow, B Stieger, M Alyari, J Dolen, J George, A Godshalk, C Harrington, I Iashvili, J Kaisen, A Kharchilava, A Kumar, A Parker, S Rappoccio, B Roozbahani, G Alverson, E Barberis, D Baumgartel, A Hortiangtham, A Massironi, D M Morse, D Nash, T Orimoto, R Teixeira De Lima, D Trocino, R-J Wang, D Wood, S Bhattacharya, K A Hahn, A Kubik, A Kumar, J F Low, N Mucia, N Odell, B Pollack, M H Schmitt, K Sung, M Trovato, M Velasco, N Dev, M Hildreth, K Hurtado Anampa, C Jessop, D J Karmgard, N Kellams, K Lannon, N Marinelli, F Meng, C Mueller, Y Musienko, M Planer, A Reinsvold, R Ruchti, G Smith, S Taroni, N Valls, M Wayne, M Wolf, A Woodard, J Alimena, L Antonelli, J Brinson, B Bylsma, L S Durkin, S Flowers, B Francis, A Hart, C Hill, R Hughes, W Ji, B Liu, W Luo, D Puigh, B L Winer, H W Wulsin, S Cooperstein, O Driga, P Elmer, J Hardenbrook, P Hebda, J Luo, D Marlow, T Medvedeva, K Mei, M Mooney, J Olsen, C Palmer, P Piroué, D Stickland, C Tully, A Zuranski, S Malik, A Barker, V E Barnes, S Folgueras, L Gutay, M K Jha, M Jones, A W Jung, K Jung, D H Miller, N Neumeister, B C Radburn-Smith, X Shi, J Sun, A Svyatkovskiy, F Wang, W Xie, L Xu, N Parashar, J Stupak, A Adair, B Akgun, Z Chen, K M Ecklund, F J M Geurts, M Guilbaud, W Li, B Michlin, M Northup, B P Padley, R Redjimi, J Roberts, J Rorie, Z Tu, J Zabel, B Betchart, A Bodek, P de Barbaro, R Demina, Y T Duh, T Ferbel, M Galanti, A Garcia-Bellido, J Han, O Hindrichs, A Khukhunaishvili, K H Lo, P Tan, M Verzetti, J P Chou, E Contreras-Campana, Y Gershtein, T A Gómez Espinosa, E Halkiadakis, M Heindl, D Hidas, E Hughes, S Kaplan, R Kunnawalkam Elayavalli, S Kyriacou, A Lath, K Nash, H Saka, S Salur, S Schnetzer, D Sheffield, S Somalwar, R Stone, S Thomas, P Thomassen, M Walker, M Foerster, J Heideman, G Riley, K Rose, S Spanier, K Thapa, O Bouhali, A Celik, M Dalchenko, M De Mattia, A Delgado, S Dildick, R Eusebi, J Gilmore, T Huang, E Juska, T Kamon, R Mueller, Y Pakhotin, R Patel, A Perloff, L Perniè, D Rathjens, A Rose, A Safonov, A Tatarinov, K A Ulmer, N Akchurin, C Cowden, J Damgov, C Dragoiu, P R Dudero, J Faulkner, S Kunori, K Lamichhane, S W Lee, T Libeiro, S Undleeb, I Volobouev, Z Wang, A G Delannoy, S Greene, A Gurrola, R Janjam, W Johns, C Maguire, A Melo, H Ni, P Sheldon, S Tuo, J Velkovska, Q Xu, M W Arenton, P Barria, B Cox, J Goodell, R Hirosky, A Ledovskoy, H Li, C Neu, T Sinthuprasith, X Sun, Y Wang, E Wolfe, F Xia, C Clarke, R Harr, P E Karchin, P Lamichhane, J Sturdy, D A Belknap, S Dasu, L Dodd, S Duric, B Gomber, M Grothe, M Herndon, A Hervé, P Klabbers, A Lanaro, A Levine, K Long, R Loveless, I Ojalvo, T Perry, G A Pierro, G Polese, T Ruggles, A Savin, A Sharma, N Smith, W H Smith, D Taylor, N Woods
The production cross section of a W boson in association with two b jets is measured using a sample of proton-proton collisions at [Formula: see text] collected by the CMS experiment at the CERN LHC. The data sample corresponds to an integrated luminosity of 19.8[Formula: see text]. The W bosons are reconstructed via their leptonic decays, [Formula: see text], where [Formula: see text] or [Formula: see text]. The fiducial region studied contains exactly one lepton with transverse momentum [Formula: see text] and pseudorapidity [Formula: see text], with exactly two b jets with [Formula: see text] and [Formula: see text] and no other jets with [Formula: see text] and [Formula: see text]...
2017: European Physical Journal. C, Particles and Fields
https://www.readbyqxmd.com/read/28330716/the-value-of-power-doppler-ultrasound-in-patients-with-rheumatoid-arthritis-in-clinical-remission-reclassifying-disease-activity
#3
Facundo Vergara, Santiago Ruta, Javier Rosa, Josefina Marín, Ricardo García-Mónaco, Enrique R Soriano
OBJECTIVES: The aim of the present study was to describe the ultrasound (US) findings in patients with rheumatoid arthritis (RA) in clinical remission, and to evaluate the ability of power Doppler (PD) US to reclassify disease activity in these patients. MATERIAL AND METHODS: We included consecutive patients with RA according to 2010 American College of Rheumatology/European League Against Rheumatism criteria, who were in clinical remission by the Disease Activity Score (DAS28<2...
March 18, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28320259/levosimendan-for-hemodynamic-support-after-cardiac-surgery
#4
Giovanni Landoni, Vladimir V Lomivorotov, Gabriele Alvaro, Rosetta Lobreglio, Antonio Pisano, Fabio Guarracino, Maria G Calabrò, Evgeny V Grigoryev, Valery V Likhvantsev, Marcello F Salgado-Filho, Alessandro Bianchi, Vadim V Pasyuga, Massimo Baiocchi, Federico Pappalardo, Fabrizio Monaco, Vladimir A Boboshko, Marat N Abubakirov, Bruno Amantea, Rosalba Lembo, Luca Brazzi, Luigi Verniero, Pietro Bertini, Anna M Scandroglio, Tiziana Bove, Alessandro Belletti, Maria G Michienzi, Dmitriy L Shukevich, Tatiana S Zabelina, Rinaldo Bellomo, Alberto Zangrillo
Background Acute left ventricular dysfunction is a major complication of cardiac surgery and is associated with increased mortality. Meta-analyses of small trials suggest that levosimendan may result in a higher rate of survival among patients undergoing cardiac surgery. Methods We conducted a multicenter, randomized, double-blind, placebo-controlled trial involving patients in whom perioperative hemodynamic support was indicated after cardiac surgery, according to prespecified criteria. Patients were randomly assigned to receive levosimendan (in a continuous infusion at a dose of 0...
March 21, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28319282/stereotactic-radiosurgery-for-essential-tremor-retrospective-analysis-of-a-19-year-experience
#5
Ajay Niranjan, Sudesh S Raju, Ali Kooshkabadi, Edward Monaco, John C Flickinger, L Dade Lunsford
BACKGROUND: Essential Tremor (ET) is a common movement disorder that can be disabling. Initial treatment is in the form of medical therapies. Patients with medically refractory ET seek surgical intervention which include radiofrequency thalamotomy, deep brain stimulation, and radiosurgical thalamotomy. Radiosurgical thalamotomy is a minimally invasive surgical option which is especially valuable for elderly and high surgical risk patients. OBJECTIVE: The purpose of this study was to retrospectively analyze the outcomes of stereotactic radiosurgery for patients suffering from medically refractory essential tremor...
March 20, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28319050/extracellular-matrix-proteomics-identifies-molecular-signature-of-symptomatic-carotid-plaques
#6
Sarah R Langley, Karin Willeit, Athanasios Didangelos, Ljubica Perisic Matic, Philipp Skroblin, Javier Barallobre-Barreiro, Mariette Lengquist, Gregor Rungger, Alexander Kapustin, Ludmilla Kedenko, Chris Molenaar, Ruifang Lu, Temo Barwari, Gonca Suna, Xiaoke Yin, Bernhard Iglseder, Bernhard Paulweber, Peter Willeit, Joseph Shalhoub, Gerard Pasterkamp, Alun H Davies, Claudia Monaco, Ulf Hedin, Catherine M Shanahan, Johann Willeit, Stefan Kiechl, Manuel Mayr
BACKGROUND: The identification of patients with high-risk atherosclerotic plaques prior to the manifestation of clinical events remains challenging. Recent findings question histology- and imaging-based definitions of the "vulnerable plaque," necessitating an improved approach for predicting onset of symptoms. METHODS: We performed a proteomics comparison of the vascular extracellular matrix and associated molecules in human carotid endarterectomy specimens from 6 symptomatic versus 6 asymptomatic patients to identify a protein signature for high-risk atherosclerotic plaques...
March 20, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28299456/interlocking-horizontal-mattress-suture-versus-kakiuchi-technique-in-repair-of-achilles-tendon-rupture-a-biomechanical-study
#7
Matteo Guzzini, Riccardo Maria Lanzetti, Lorenzo Proietti, Daniele Mazza, Mattia Fabbri, Edoardo Monaco, Germano Ferri, Andrea Ferretti
BACKGROUND: In recent years, the type of surgical treatment for Achilles tendon rupture has been the subject of controversial debate. This biomechanical study evaluates for the first time in literature the ultimate failure load (UFL) of interlocking horizontal mattress (IHM) suture as compared with Kakiuchi suture in Achilles tendon rupture. The hypothesis is that IHM suture can be performed also for Achilles tendon rupture and ensures higher resistance compared with the traditional Kakiuchi suture...
March 15, 2017: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/28298940/image-guided-thermal-ablation-of-benign-thyroid-nodules
#8
REVIEW
Anna Pisani Mainini, Cristian Monaco, Lorenzo Carlo Pescatori, Chiara De Angelis, Francesco Sardanelli, Luca Maria Sconfienza, Giovanni Mauri
Benign thyroid nodules are a common disease in the general population. Most often, they are completely asymptomatic and discovered occasionally during routine ultrasound examinations, and do not require any treatment. When thyroid nodules become symptomatic, surgical excision is still considered standard treatment. In the last few years, several experiences in the treatment of benign thyroid nodules through image-guided percutaneous thermal ablation have been reported with encouraging results, so that currently, these treatments are often proposed as first-choice options for patients with symptomatic benign thyroid nodules...
March 2017: Journal of Ultrasound
https://www.readbyqxmd.com/read/28298604/prion-strain-characterization-of-a-novel-subtype-of-creutzfeldt-jakob-disease
#9
Roberta Galeno, Michele Angelo Di Bari, Romolo Nonno, Franco Cardone, Marco Sbriccoli, Silvia Graziano, Loredana Ingrosso, Michele Fiorini, Angelina Valanzano, Giulia Pasini, Anna Poleggi, Ramona Vinci, Anna Ladogana, Maria Puopolo, Salvatore Monaco, Umberto Agrimi, Gianluigi Zanusso, Maurizio Pocchiari
In 2007, we reported a patient with an atypical form of Creutzfeldt-Jakob disease (CJD), heterozygous for methionine-valine (MV) at codon 129, who showed a novel pathological prion protein (PrP(TSE)) conformation with an atypical glycoform (AG) profile and an intraneuronal PrP deposition. In the present study, we further characterized the conformational properties of this pathological prion protein (PrP(TSE) MV(AG)) showing that PrP(TSE) MV(AG) is composed by multiple conformers with biochemical properties distinct from PrP(TSE) type 1 and type 2 of MV sporadic CJD (sCJD)...
March 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28298016/a-proposed-plan-for-personalized-radiosurgery-in-patients-with-trigeminal-neuralgia
#10
Seyed H Mousavi, Ajay Niranjan, Berkcan Akpinar, Edward A Monaco, Jonathan Cohen, Jagdish Bhatnagar, Yue-Fang Chang, Hideyuki Kano, Sakibul Huq, John C Flickinger, L Dade Lunsford
OBJECTIVE During the last 25 years, more than 100,000 patients worldwide with trigeminal neuralgia (TN) have undergone stereotactic radiosurgery (SRS) with a standard dose of radiation. However, the radiobiological effect of radiation is determined by the amount of energy delivered to the tissue (integral dose [ID] = mean dose × target volume) and is directly associated with the nerve volume. Although the trigeminal nerve volume varies among patients with TN, the clinical impact of this variation in delivered energy is unknown...
February 17, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28297319/modeling-the-agility-mlc-in-the-monaco-treatment-planning-system
#11
Michael Snyder, Robert Halford, Cory Knill, Jeffrey N Adams, Todd Bossenberger, Adrian Nalichowski, Ahmad Hammoud, Jay Burmeister
We investigate the relationship between the various parameters in the Monaco MLC model and dose calculation accuracy for an Elekta Agility MLC. The vendor-provided MLC modeling procedure - completed first with external vendor participation and then exclusively in-house - was used in combination with our own procedures to investigate several sets of MLC modeling parameters to determine their effect on dose distributions and point-dose measurements. Simple plans provided in the vendor procedure were used to elucidate specific mechanical characteristics of the MLC, while ten complex treatment plans - five IMRT and five VMAT - created using TG-119-based structure sets were used to test clinical dosimetric effects of particular parameter choices...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297303/experimental-evaluation-of-a-gpu-based-monte-carlo-dose-calculation-algorithm-in-the-monaco-treatment-planning-system
#12
Moti R Paudel, Anthony Kim, Arman Sarfehnia, Sayed B Ahmad, David J Beachey, Arjun Sahgal, Brian M Keller
A new GPU-based Monte Carlo dose calculation algorithm (GPUMCD), developed by the vendor Elekta for the Monaco treatment planning system (TPS), is capable of modeling dose for both a standard linear accelerator and an Elekta MRI linear accelerator. We have experimentally evaluated this algorithm for a standard Elekta Agility linear accelerator. A beam model was developed in the Monaco TPS (research version 5.09.06) using the commissioned beam data for a 6 MV Agility linac. A heterogeneous phantom representing several scenarios - tumor-in-lung, lung, and bone-in-tissue - was designed and built...
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28296313/determination-of-mlc-model-parameters-for-monaco-using-commercial-diode-arrays
#13
Paul Kinsella, Laura Shields, Patrick McCavana, Brendan McClean, Brian Langan
Multileaf collimators (MLCs) need to be characterized accurately in treatment planning systems to facilitate accurate intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT). The aim of this study was to examine the use of MapCHECK 2 and ArcCHECK diode arrays for optimizing MLC parameters in Monaco X-ray voxel Monte Carlo (XVMC) dose calculation algorithm. A series of radiation test beams designed to evaluate MLC model parameters were delivered to MapCHECK 2, ArcCHECK, and EBT3 Gafchromic film for comparison...
July 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28269666/principal-component-analysis-can-decrease-neural-networks-performance-for-incipient-falls-detection-a-preliminary-study-with-hands-and-feet-accelerations
#14
Fiorenzo Artoni, Dario Martelli, Vito Monaco, Silvestre Micera
Fall-related accidents constitute a major problem for elderly people and a burden to the health-care national system. It is therefore important to design devices (e.g., accelerometers) and machine learning algorithms able to recognize incipient falls as quickly and reliably as possible. Blind source separation (BSS) methods are often used as a preprocessing step before classification, however the effects of BSS on classification performance are not well understood. The aim of this work is to preliminarily characterize the effect that two methods, namely Principal and Independent Component Analysis (PCA and ICA) and their combined use have on the performance of a neural network in detecting incipient falls...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267421/use-of-pig-as-a-model-for-mesenchymal-stem-cell-therapies-for-bone-regeneration
#15
Marcello Rubessa, Kathryn Polkoff, Massimo Bionaz, Elisa Monaco, Derek J Milner, Scott J Holllister, Michael S Goldwasser, Matthew B Wheeler
Bone is a plastic tissue with a large healing capability. However, extensive bone loss due to disease or trauma requires extreme therapy such as bone grafting or tissue-engineering applications. Presently, bone grafting is the gold standard for bone repair, but presents serious limitations including donor site morbidity, rejection, and limited tissue regeneration. The use of stem cells appears to be a means to overcome such limitations. Bone marrow mesenchymal stem cells (BMSC) have been the choice thus far for stem cell therapy for bone regeneration...
March 7, 2017: Animal Biotechnology
https://www.readbyqxmd.com/read/28260978/measurements-of-the-formula-see-text-production-cross-section-in-lepton-jets-final-states-in-pp-collisions-at-8-formula-see-text-and-ratio-of-8-to-7%C3%A2-formula-see-text-cross-sections
#16
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Zorbilmez, I V Akin, B Bilin, S Bilmis, B Isildak, G Karapinar, M Yalvac, M Zeyrek, E Gülmez, M Kaya, O Kaya, E A Yetkin, T Yetkin, A Cakir, K Cankocak, S Sen, F I Vardarlı, B Grynyov, L Levchuk, P Sorokin, R Aggleton, F Ball, L Beck, J J Brooke, E Clement, D Cussans, H Flacher, J Goldstein, M Grimes, G P Heath, H F Heath, J Jacob, L Kreczko, C Lucas, Z Meng, D M Newbold, S Paramesvaran, A Poll, T Sakuma, S Seif El Nasr-Storey, S Senkin, D Smith, V J Smith, K W Bell, A Belyaev, C Brew, R M Brown, L Calligaris, D Cieri, D J A Cockerill, J A Coughlan, K Harder, S Harper, E Olaiya, D Petyt, C H Shepherd-Themistocleous, A Thea, I R Tomalin, T Williams, W J Womersley, S D Worm, M Baber, R Bainbridge, O Buchmuller, A Bundock, D Burton, S Casasso, M Citron, D Colling, L Corpe, N Cripps, P Dauncey, G Davies, A De Wit, M Della Negra, P Dunne, A Elwood, W Ferguson, J Fulcher, D Futyan, G Hall, G Iles, M Kenzie, R Lane, R Lucas, L Lyons, A-M Magnan, S Malik, J Nash, A Nikitenko, J Pela, M Pesaresi, K Petridis, D M Raymond, A Richards, A Rose, C Seez, A Tapper, K Uchida, M Vazquez Acosta, T Virdee, S C Zenz, J E Cole, P R Hobson, A Khan, P Kyberd, D Leggat, D Leslie, I D Reid, P Symonds, L Teodorescu, M Turner, A Borzou, K Call, J Dittmann, K Hatakeyama, H Liu, N Pastika, O Charaf, S I Cooper, C Henderson, P Rumerio, D Arcaro, A Avetisyan, T Bose, C Fantasia, D Gastler, P Lawson, D Rankin, C Richardson, J Rohlf, J St John, L Sulak, D Zou, J Alimena, E Berry, S Bhattacharya, D Cutts, N Dhingra, A Ferapontov, A Garabedian, J Hakala, U Heintz, E Laird, G Landsberg, Z Mao, M Narain, S Piperov, S Sagir, R Syarif, R Breedon, G Breto, M Calderon De La Barca Sanchez, S Chauhan, M Chertok, J Conway, R Conway, P T Cox, R Erbacher, M Gardner, W Ko, R Lander, M Mulhearn, D Pellett, J Pilot, F Ricci-Tam, S Shalhout, J Smith, M Squires, D Stolp, M Tripathi, S Wilbur, R Yohay, R Cousins, P Everaerts, C Farrell, J Hauser, M Ignatenko, D Saltzberg, E Takasugi, V Valuev, M Weber, K Burt, R Clare, J Ellison, J W Gary, G Hanson, J Heilman, M Ivova Paneva, P Jandir, E Kennedy, F Lacroix, O R Long, A Luthra, M Malberti, M Olmedo Negrete, A Shrinivas, H Wei, S Wimpenny, B R Yates, J G Branson, G B Cerati, S Cittolin, R T D'Agnolo, M Derdzinski, A Holzner, R Kelley, D Klein, J Letts, I Macneill, D Olivito, S Padhi, M Pieri, M Sani, V Sharma, S Simon, M Tadel, A Vartak, S Wasserbaech, C Welke, F Würthwein, A Yagil, G Zevi Della Porta, J Bradmiller-Feld, C Campagnari, A Dishaw, V Dutta, K Flowers, M Franco Sevilla, P Geffert, C George, F Golf, L Gouskos, J Gran, J Incandela, N Mccoll, S D Mullin, J Richman, D Stuart, I Suarez, C West, J Yoo, D Anderson, A Apresyan, A Bornheim, J Bunn, Y Chen, J Duarte, A Mott, H B Newman, C Pena, M Pierini, M Spiropulu, J R Vlimant, S Xie, R Y Zhu, M B Andrews, V Azzolini, A Calamba, B Carlson, T Ferguson, M Paulini, J Russ, M Sun, H Vogel, I Vorobiev, J P Cumalat, W T Ford, A Gaz, F Jensen, A Johnson, M Krohn, T Mulholland, U Nauenberg, K Stenson, S R Wagner, J Alexander, A Chatterjee, J Chaves, J Chu, S Dittmer, N Eggert, N Mirman, G Nicolas Kaufman, J R Patterson, A Rinkevicius, A Ryd, L Skinnari, L Soffi, W Sun, S M Tan, W D Teo, J Thom, J Thompson, J Tucker, Y Weng, P Wittich, S Abdullin, M Albrow, J Anderson, G Apollinari, S Banerjee, L A T Bauerdick, A Beretvas, J Berryhill, P C Bhat, G Bolla, K Burkett, J N Butler, H W K Cheung, F Chlebana, S Cihangir, V D Elvira, I Fisk, J Freeman, E Gottschalk, L Gray, D Green, S Grünendahl, O Gutsche, J Hanlon, D Hare, R M Harris, S Hasegawa, J Hirschauer, Z Hu, B Jayatilaka, S Jindariani, M Johnson, U Joshi, A W Jung, B Klima, B Kreis, S Kwan, S Lammel, J Linacre, D Lincoln, R Lipton, T Liu, R Lopes De Sá, J Lykken, K Maeshima, J M Marraffino, V I Martinez Outschoorn, S Maruyama, D Mason, P McBride, P Merkel, K Mishra, S Mrenna, S Nahn, C Newman-Holmes, V O'Dell, K Pedro, O Prokofyev, G Rakness, E Sexton-Kennedy, A Soha, W J Spalding, L Spiegel, L Taylor, S Tkaczyk, N V Tran, L Uplegger, E W Vaandering, C Vernieri, M Verzocchi, R Vidal, H A Weber, A Whitbeck, F Yang, D Acosta, P Avery, P Bortignon, D Bourilkov, A Carnes, M Carver, D Curry, S Das, G P Di Giovanni, R D Field, I K Furic, S V Gleyzer, J Hugon, J Konigsberg, A Korytov, J F Low, P Ma, K Matchev, H Mei, P Milenovic, G Mitselmakher, D Rank, R Rossin, L Shchutska, M Snowball, D Sperka, N Terentyev, L Thomas, J Wang, S Wang, J Yelton, S Hewamanage, S Linn, P Markowitz, G Martinez, J L Rodriguez, A Ackert, J R Adams, T Adams, A Askew, J Bochenek, B Diamond, J Haas, S Hagopian, V Hagopian, K F Johnson, A Khatiwada, H Prosper, M Weinberg, M M Baarmand, V Bhopatkar, S Colafranceschi, M Hohlmann, H Kalakhety, D Noonan, T Roy, F Yumiceva, M R Adams, L Apanasevich, D Berry, R R Betts, I Bucinskaite, R Cavanaugh, O Evdokimov, L Gauthier, C E Gerber, D J Hofman, P Kurt, C O'Brien, I D Sandoval Gonzalez, C Silkworth, P Turner, N Varelas, Z Wu, M Zakaria, B Bilki, W Clarida, K Dilsiz, S Durgut, R P Gandrajula, M Haytmyradov, V Khristenko, J-P Merlo, H Mermerkaya, A Mestvirishvili, A Moeller, J Nachtman, H Ogul, Y Onel, F Ozok, A Penzo, C Snyder, E Tiras, J Wetzel, K Yi, I Anderson, B A Barnett, B Blumenfeld, N Eminizer, D Fehling, L Feng, A V Gritsan, P Maksimovic, C Martin, M Osherson, J Roskes, A Sady, U Sarica, M Swartz, M Xiao, Y Xin, C You, P Baringer, A Bean, G Benelli, C Bruner, R P Kenny, D Majumder, M Malek, M Murray, S Sanders, R Stringer, Q Wang, A Ivanov, K Kaadze, S Khalil, M Makouski, Y Maravin, A Mohammadi, L K Saini, N Skhirtladze, S Toda, D Lange, F Rebassoo, D Wright, C Anelli, A Baden, O Baron, A Belloni, B Calvert, S C Eno, C Ferraioli, J A Gomez, N J Hadley, S Jabeen, R G Kellogg, T Kolberg, J Kunkle, Y Lu, A C Mignerey, Y H Shin, A Skuja, M B Tonjes, S C Tonwar, A Apyan, R Barbieri, A Baty, K Bierwagen, S Brandt, W Busza, I A Cali, Z Demiragli, L Di Matteo, G Gomez Ceballos, M Goncharov, D Gulhan, Y Iiyama, G M Innocenti, M Klute, D Kovalskyi, Y S Lai, Y-J Lee, A Levin, P D Luckey, A C Marini, C Mcginn, C Mironov, S Narayanan, X Niu, C Paus, D Ralph, C Roland, G Roland, J Salfeld-Nebgen, G S F Stephans, K Sumorok, M Varma, D Velicanu, J Veverka, J Wang, T W Wang, B Wyslouch, M Yang, V Zhukova, B Dahmes, A Evans, A Finkel, A Gude, P Hansen, S Kalafut, S C Kao, K Klapoetke, Y Kubota, Z Lesko, J Mans, S Nourbakhsh, N Ruckstuhl, R Rusack, N Tambe, J Turkewitz, J G Acosta, S Oliveros, E Avdeeva, K Bloom, S Bose, D R Claes, A Dominguez, C Fangmeier, R Gonzalez Suarez, R Kamalieddin, J Keller, D Knowlton, I Kravchenko, F Meier, J Monroy, F Ratnikov, J E Siado, G R Snow, M Alyari, J Dolen, J George, A Godshalk, C Harrington, I Iashvili, J Kaisen, A Kharchilava, A Kumar, S Rappoccio, B Roozbahani, G Alverson, E Barberis, D Baumgartel, M Chasco, A Hortiangtham, A Massironi, D M Morse, D Nash, T Orimoto, R Teixeira De Lima, D Trocino, R-J Wang, D Wood, J Zhang, K A Hahn, A Kubik, N Mucia, N Odell, B Pollack, A Pozdnyakov, M Schmitt, S Stoynev, K Sung, M Trovato, M Velasco, A Brinkerhoff, N Dev, M Hildreth, C Jessop, D J Karmgard, N Kellams, K Lannon, S Lynch, N Marinelli, F Meng, C Mueller, Y Musienko, T Pearson, M Planer, A Reinsvold, R Ruchti, G Smith, S Taroni, N Valls, M Wayne, M Wolf, A Woodard, L Antonelli, J Brinson, B Bylsma, L S Durkin, S Flowers, A Hart, C Hill, R Hughes, W Ji, K Kotov, T Y Ling, B Liu, W Luo, D Puigh, M Rodenburg, B L Winer, H W Wulsin, O Driga, P Elmer, J Hardenbrook, P Hebda, S A Koay, P Lujan, D Marlow, T Medvedeva, M Mooney, J Olsen, C Palmer, P Piroué, H Saka, D Stickland, C Tully, A Zuranski, S Malik, V E Barnes, D Benedetti, D Bortoletto, L Gutay, M K Jha, M Jones, K Jung, D H Miller, N Neumeister, B C Radburn-Smith, X Shi, I Shipsey, D Silvers, J Sun, A Svyatkovskiy, F Wang, W Xie, L Xu, N Parashar, J Stupak, A Adair, B Akgun, Z Chen, K M Ecklund, F J M Geurts, M Guilbaud, W Li, B Michlin, M Northup, B P Padley, R Redjimi, J Roberts, J Rorie, Z Tu, J Zabel, B Betchart, A Bodek, P de Barbaro, R Demina, Y Eshaq, T Ferbel, M Galanti, A Garcia-Bellido, J Han, A Harel, O Hindrichs, A Khukhunaishvili, G Petrillo, P Tan, M Verzetti, S Arora, A Barker, J P Chou, C Contreras-Campana, E Contreras-Campana, D Duggan, D Ferencek, Y Gershtein, R Gray, E Halkiadakis, D Hidas, E Hughes, S Kaplan, R Kunnawalkam Elayavalli, A Lath, K Nash, S Panwalkar, M Park, S Salur, S Schnetzer, D Sheffield, S Somalwar, R Stone, S Thomas, P Thomassen, M Walker, M Foerster, G Riley, K Rose, S Spanier, A York, O Bouhali, A Castaneda Hernandez, M Dalchenko, M De Mattia, A Delgado, S Dildick, R Eusebi, J Gilmore, T Kamon, V Krutelyov, R Mueller, I Osipenkov, Y Pakhotin, R Patel, A Perloff, A Rose, A Safonov, A Tatarinov, K A Ulmer, N Akchurin, C Cowden, J Damgov, C Dragoiu, P R Dudero, J Faulkner, S Kunori, K Lamichhane, S W Lee, T Libeiro, S Undleeb, I Volobouev, E Appelt, A G Delannoy, S Greene, A Gurrola, R Janjam, W Johns, C Maguire, Y Mao, A Melo, H Ni, P Sheldon, B Snook, S Tuo, J Velkovska, Q Xu, M W Arenton, B Cox, B Francis, J Goodell, R Hirosky, A Ledovskoy, H Li, C Lin, C Neu, T Sinthuprasith, X Sun, Y Wang, E Wolfe, J Wood, F Xia, C Clarke, R Harr, P E Karchin, C Kottachchi Kankanamge Don, P Lamichhane, J Sturdy, D A Belknap, D Carlsmith, M Cepeda, S Dasu, L Dodd, S Duric, B Gomber, M Grothe, R Hall-Wilton, M Herndon, A Hervé, P Klabbers, A Lanaro, A Levine, K Long, R Loveless, A Mohapatra, I Ojalvo, T Perry, G A Pierro, G Polese, T Ruggles, T Sarangi, A Savin, A Sharma, N Smith, W H Smith, D Taylor, N Woods
A measurement of the top quark pair production ([Formula: see text]) cross section in proton-proton collisions at the centre-of-mass energy of 8[Formula: see text] is presented using data collected with the CMS detector at the LHC, corresponding to an integrated luminosity of 19.6[Formula: see text]. This analysis is performed in the [Formula: see text] decay channels with one isolated, high transverse momentum electron or muon and at least four jets, at least one of which is required to be identified as originating from hadronization of a b quark...
2017: European Physical Journal. C, Particles and Fields
https://www.readbyqxmd.com/read/28259442/kawasaki-disease-and-immunisation-a-systematic-review
#17
Linny Kimly Phuong, Caterina Bonetto, Jim Buttery, Yolanda Brauchli Pernus, Rebecca Chandler, Patrizia Felicetti, Karen L Goldenthal, Merita Kucuku, Giuseppe Monaco, Barbara Pahud, Stanford T Shulman, Karina A Top, Francesco Trotta, Rolando Ulloa-Gutierrez, Frederick Varricchio, Sarah de Ferranti, Jane W Newburger, Nagib Dahdah, Surjit Singh, Jan Bonhoeffer, David Burgner
BACKGROUND: Kawasaki disease is a complex and potentially serious condition. It has been observed in temporal relation to immunisation. METHODS: We conducted a systematic literature review using various reference sources to review the available evidence published in the literature. RESULTS: We identified twenty seven publications reporting a temporal association between immunisation and Kawasaki disease. We present a systematic review of data drawn from randomised controlled trials, observational studies, case series and reports, and reviews...
March 2, 2017: Vaccine
https://www.readbyqxmd.com/read/28258036/use-of-ace-inhibitors-and-falls-in-patients-with-parkinson-s-disease
#18
Alice Laudisio, Maria Rita Lo Monaco, Maria Caterina Silveri, Anna Rita Bentivoglio, Davide L Vetrano, Maria Stella Pisciotta, Vincenzo Brandi, Roberto Bernabei, Giuseppe Zuccalà
Falls represent a major concern in patients with Parkinson's disease (PD); however, currently acknowledged treatments for PD are not effective in reducing the risk of falling. The aim was to assess the association of use of ACE-inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) with falls among patients with PD. We analysed data of 194 elderly with PD attending a geriatric Day Hospital. Self-reported history of falls that occurred over the last year, as well as use of drugs, including ACEIs and angiotensin II receptor blockers (ARBs) were recorded...
February 22, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28256158/treatment-outcomes-and-patterns-of-radiologic-appearance-after-hypofractionated-image-guided-radiotherapy-delivered-with-helical-tomotherapy-hht-for-lung-tumours
#19
Stefano Arcangeli, Lorenzo Falcinelli, Stefano Bracci, Alessandro Greco, Alessia Monaco, Jessica Dognini, Cinzia Chiostrini, Rita Bellavita, Cynthia Aristei, Vittorio Donato
OBJECTIVE: To evaluate treatment outcomes and patterns of CT lung injury after hypofractionated image-guided radiotherapy delivered with helical tomotherapy (HHT) in a series of inoperable lung lesions. METHODS: 68 patients who were medically inoperable (69 lesions) without evidence of viable extrathoracic disease were included. Dose prescription was driven by tumour location (hilar/pericentral vs peripheral) and/or target volume. 52% of the lesions received a biological equivalent dose (BED10) ≥100 Gy...
March 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28247930/identification-of-murine-phosphodiesterase-5a-isoforms-and-their-functional-characterization-in-hl-1-cardiac-cell-line
#20
Federica Campolo, Alessandra Zevini, Silvia Cardarelli, Lucia Monaco, Federica Barbagallo, Manuela Pellegrini, Marisa Cornacchione, Antonio Di Grazia, Valeria De Arcangelis, Daniele Gianfrilli, Mauro Giorgi, Andrea Lenzi, Andrea M Isidori, Fabio Naro
Phosphodiesterase 5A (PDE5A) specifically degrades the ubiquitous second messenger cGMP and experimental and clinical data highlight its important role in cardiac diseases. To address PDE5A role in cardiac physiology, three splice variants of the PDE5A were cloned for the first time from mouse cDNA library (mPde5a1, mPde5a2 and mPde5a3). The predicted amino acidic sequences of the three murine isoforms are different in the N-terminal regulatory domain. mPDE5A isoforms were transfected in HEK293T cells and they showed high affinity for cGMP and similar sensitivity to sildenafil inhibition...
March 1, 2017: Journal of Cellular Physiology
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