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https://www.readbyqxmd.com/read/29664813/development-and-validation-of-nomograms-predicting-overall-and-cancer-specific-survival-of-spinal-chondrosarcoma-patients
#1
Kehan Song, Jian Song, Xio Shi, Hongli Wang, Xiaosheng Ma, Xinlei Xia, Xin Liang, Kaiyuan Lin, Jianyuan Jiang
STUDY DESIGN: Retrospective analysis. OBJECTIVE: To develop and validate nomograms to predict overall survival (OS) and cancer-specific survival (CSS) of spinal chondrosarcoma patients. SUMMARY OF BACKGROUND DATA: In this era of personalized medicine, data those are available to predict the survival of spinal chondrosarcoma patients are still limited due to the rarity of the disease. Nomogram, which has been widely used in clinical oncology, could conveniently and precisely predict survival outcome for individual patient...
April 16, 2018: Spine
https://www.readbyqxmd.com/read/29555755/xio-is-a-component-of-the-drosophila-sex-determination-pathway-and-rna-n-6-methyladenosine-methyltransferase-complex
#2
Jian Guo, Hong-Wen Tang, Jing Li, Norbert Perrimon, Dong Yan
N 6 -methyladenosine (m6 A), the most abundant chemical modification in eukaryotic mRNA, has been implicated in Drosophila sex determination by modifying Sex-lethal ( Sxl ) pre-mRNA and facilitating its alternative splicing. Here, we identify a sex determination gene, CG7358 , and rename it xio according to its loss-of-function female-to-male transformation phenotype. xio encodes a conserved ubiquitous nuclear protein of unknown function. We show that Xio colocalizes and interacts with all previously known m6 A writer complex subunits (METTL3, METTL14, Fl(2)d/WTAP, Vir/KIAA1429, and Nito/Rbm15) and that loss of xio is associated with phenotypes that resemble other m6 A factors, such as sexual transformations, Sxl splicing defect, held-out wings, flightless flies, and reduction of m6 A levels...
March 19, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29516910/-in-vivo-dose-estimations-through-transit-signal-measured-with-thimble-chamber-positioned-along-the-central-axis-at-electronic-portal-imaging-device-level-in-medical-linear-accelerator-in-carcinoma-of-the-middle-third-esophagus-patients-undergoing-three-dimensional
#3
Putha Suman Kumar, S Banerjee, E S Arun Kumar, Challapalli Srinivas, B M Vadhiraja, P U Saxena, Ramamoorthy Ravichandran, Dinesh Pai Kasturi
Objective: This study presents a method to estimate midplane dose (Diso, transit ) in vivo from transit signal (St ) measured with thimble ionization chamber in cancer of the middle-third esophagus patients treated with three-dimensional radiotherapy (RT). This detector is positioned at the level of electronic portal imaging device in the gantry of a medical linear accelerator. Materials and Methods: Efficacy of inhomogeneity corrections of three dose calculation algorithms available in XiO treatment planning system (TPS) for planned dose (for open fields) (Diso, TPS ) was studied with three heterogeneous phantoms...
January 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29195558/comprehensive-clinical-commissioning-and-validation-of-the-raystation-treatment-planning-system-for-proton-therapy-with-active-scanning-and-passive-treatment-techniques
#4
C Bäumer, D Geismar, B Koska, P H Kramer, J Lambert, M Lemke, S Plaude, L Pschichholz, S Qamhiyeh, A Schiemann, B Timmermann, X Vermeren
PURPOSE: To commission the treatment planning system (TPS) RayStation for proton therapy including beam models for spot scanning and for uniform scanning. METHODS: Tests consist of procedures from ESTRO booklet number 7, the German DIN for constancy checks of TPSs, and extra tests checking the dose perturbation function. The dose distributions within patients were verified in silico by a comparison of 65 clinical treatment plans with the TPS XiO. Dose-volume parameters, dose differences, and three-dimensional gamma-indices serve as measures of similarity...
November 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/29173926/measurement-of-the-influence-of-titanium-hip-prosthesis-on-therapeutic-electron-beam-dose-distributions-in-a-novel-pelvic-phantom
#5
Nicholas Ade, F C P du Plessis
PURPOSE: To investigate the degree of 18 and 22MeV electron beam dose perturbations caused by unilateral hip titanium (Ti) prosthesis. METHODS: Measurements were acquired using Gafchromic EBT2 film in a novel pelvic phantom made out of Nylon-12 slices in which a Ti-prosthesis is embedded. Dose perturbations were measured and compared using depth doses for 8×8, 10×10 and 11×11cm2 applicator-defined field sizes at 95cm source-surface-distance (SSD). Comparisons were also made between film data at 100cm SSD for a 10×10cm2 field and dose calculations made on CMS XiO treatment planning system utilizing the pencil beam algorithm...
October 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/29114698/efficacy-of-emergency-laparoscopic-appendectomy-in-treating-complicated-appendicitis-for-elderly-patients
#6
Tian-Chong Wu, Qiao Lu, Zhi-Yong Huang, Xio-Hui Liang
To assess the therapeutic effects of emergency laparoscopic appendectomy (LA) in treating complicated appendicitis (CA) for elderly patients (defined as age 65 years and above). Methods: We conducted a retrospective study of 115 elderly patients with CA who underwent surgical therapy in the Affiliated Huizhou Hospital of Sun Yat-Sun University, Huizhou, Guangdong Province, China between September 2014 and August 2016. Of these, 59 patients consented to open appendectomy (OA), and LA was performed in the other 56 patients...
November 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28741892/dose-comparison-between-gafchromic-film-xio-and-monaco-treatment-planning-systems-in-a-novel-pelvic-phantom-that-contains-a-titanium-hip-prosthesis
#7
Nicholas Ade, F C P du Plessis
The presence of metallic prostheses during external beam radiotherapy of malignancies in the pelvic region has the potential to strongly influence the dose distribution to the target and to tissue surrounded by the prostheses. This study systematically investigates the perturbation effects of unilateral titanium prosthesis on 6 and 15 MV photon beam dose distributions using Gafchromic EBT2 film measurements in a novel pelvic phantom made out of a stack of nylon slices. Comparisons were also made between the film data and dose calculations made on XiO and Monaco treatment planning systems...
July 25, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297459/on-the-use-of-a-convolution-superposition-algorithm-for-plan-checking-in-lung-stereotactic-body-radiation-therapy
#8
Nicholas Hardcastle, Bradley M Oborn, Annette Haworth
Stereotactic body radiation therapy (SBRT) aims to deliver a highly conformal ablative dose to a small target. Dosimetric verification of SBRT for lung tumors presents a challenge due to heterogeneities, moving targets, and small fields. Recent software (M3D) designed for dosimetric verification of lung SBRT treatment plans using an advanced convolution-superposition algorithm was evaluated. Ten lung SBRT patients covering a range of tumor volumes were selected. 3D CRT plans were created using the XiO treatment planning system (TPS) with the superposition algorithm...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28048260/su-f-p-37-implementation-of-an-end-to-end-qa-test-of-the-radiation-therapy-imaging-planning-and-delivery-process-to-identify-and-correct-possible-sources-of-deviation
#9
F Salinas Aranda, V Suarez, S Arbiser, R Sansogne
PURPOSE: To implement an end-to-end QA test of the radiation therapy imaging, planning and delivery process, aimed to assess the dosimetric agreement accuracy between planned and delivered treatment, in order to identify and correct possible sources of deviation. To establish an internal standard for machine commissioning acceptance. METHODS: A test involving all steps of the radiation therapy: imaging, planning and delivery process was designed. The test includes analysis of point dose and planar dose distributions agreement between TPS calculated and measured dose...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047769/su-g-tep2-12-irochouston-and-mdapl-srs-anthropomorphic-phantom-results
#10
A Molineu, S Kry, P Alvarez, N Hernandez, T Nguyen, D Followill
PURPOSE: To report the results of SRS phantom irradiations METHODS: Anthropomorphic SRS head phantoms were sent to institutions participating in NCI sponsored SRS clinical trials and institutions interested in verifying SRS treatment delivery. The phantom shell was purchased from Phantom Laboratory and altered to house dosimetry and imaging inserts. The imaging insert has 1.9 cm diameter spherical target. The dosimetry insert holds two TLD capsules and radiochromic film in the coronal and sagittal planes through the center of the target...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046697/su-f-j-203-retrospective-assessment-of-delivered-proton-dose-in-prostate-cancer-patients-based-on-daily-in-room-ct-imaging
#11
K Stuetzer, T Paessler, C Valentini, F Exner, J Thiele, T Hoelscher, M Krause, C Richter
PURPOSE: Retrospective calculation of the delivered proton dose in prostate cancer patients based on a unique dataset of daily CT images. METHODS: Inter-fractional motion in prostate cancer patients treated at our proton facility is counteracted by water-filled endorectal ballon and bladder filling protocol. Typical plans (XiO, Elekta Instruments AB, Stockholm) for 74 Gy(RBE) sequential boost treatment in 37 fractions include two series of opposing lateral double-scattered proton beams covering the respective iCTV...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046677/su-f-t-218-validation-of-an-in-vivo-proton-range-verification-method-for-reducing-the-risk-of-permanent-alopecia-in-the-treatment-of-pediatric-medulloblastoma
#12
G Lucconi, E Bentefour, S Deepak, G Janssens, K Weaver, M Moteabbed, H-M Lu
PURPOSE: The clinical commissioning of a workflow for pre-treatment range verification/adjustment for the head treatment of pediatric medulloblastoma patients, including dose monitoring during treatment. METHODS: An array of Si-diodes (DIODES Incorporated) is placed on the patient skin on the opposite side to the beam entrance. A "scout" SOBP beam, with a longer beam range to cover the diodes in its plateau, is delivered; the measured signal is analyzed and the extracted water equivalent path lengths (WEPL) are compared to the expected values, revealing if a range correction is needed...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28019086/the-risk-of-secondary-cancer-in-nasopharyngeal-carcinoma-paediatric-patients-due-to-intensity-modulated-radiotherapy-and-mega-voltage-cone-beam-computed-tomography
#13
Reham S Sherif, Ehab M Attalla, Wael M Elshemey, Noha G Madian
INTRODUCTION: There is a growing interest in the study of radiation-induced secondary cancer. The aim of this work is (i) to estimate the peripheral doses attributable to intensity modulated radiotherapy (IMRT) and mega-voltage cone beam computed tomography (MV-CBCT) for some organs at risk (OARs) which surround the target being treated (Nasopharynx) in paediatric patients. (ii) To estimate the risk of radiation-induced secondary cancers attributable to patient setup verification imaging dose using MV-CBCT for Nasopharyngeal Carcinoma (NPC) in paediatric patients and comparing it with that attributable to the therapeutic dose using IMRT...
June 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/27987466/fricke-gel-dosimeter-as-a-tool-in-quality-assurance-of-the-radiotherapy-treatment-plans
#14
Yasser S Soliman, M I El Gohary, M H Abdel Gawad, E A Amin, O S Desouky
Ferrous xylenol gel was evaluated as a dosimeter in verifications of treatment plans for treatments of female breast tumors in external-beam radiation therapy. The dosimeter was calibrated in a cubic wax phantom irradiated with 6 and 15MV beams of an Elekta clinical linear accelerator and then used for measurements of doses in an anthropomorphic phantom of a female torso, which mimicked female breasts after modified radical mastectomy and breast-conserving surgery. Doses measured with the gel in specific locations in the phantom were compared with values predicted by treatment plans created with the XiO treatment planning system (Elekta / IMPAQ) and with results of measurements with an IBA CC13 ionization chamber in the same locations...
February 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/27908184/irradiation-with-x-rays-of-the-energy-18-mv-induces-radioactivity-in-transfusion-blood-proposal-of-a-safe-method-using-6-mv
#15
Katharina Frentzel, Harun Badakhshi
PURPOSE: To prevent a fatal transfusion-associated graft-versus-host disease, it is recommended to irradiate transfusion blood and blood components with ionizing radiation. Using x-rays from a linear accelerator of the radiotherapy department is an accepted alternative to gamma irradiation devices of the blood bank and to the orthovoltage units that are replacing the gamma irradiators today. However, the use of high energy x-rays may carry a potential risk of induced radioactivity. The objective of this study was to investigate the effect of two different energy levels, 6 and 18 MV, which are executed in routine clinical settings...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27755571/accurate-classification-of-rna-structures-using-topological-fingerprints
#16
Jiajie Huang, Kejie Li, Michael Gribskov
While RNAs are well known to possess complex structures, functionally similar RNAs often have little sequence similarity. While the exact size and spacing of base-paired regions vary, functionally similar RNAs have pronounced similarity in the arrangement, or topology, of base-paired stems. Furthermore, predicted RNA structures often lack pseudoknots (a crucial aspect of biological activity), and are only partially correct, or incomplete. A topological approach addresses all of these difficulties. In this work we describe each RNA structure as a graph that can be converted to a topological spectrum (RNA fingerprint)...
2016: PloS One
https://www.readbyqxmd.com/read/27741379/dosimetric-and-radiobiological-impact-of-intensity-modulated-proton-therapy-and-rapidarc-planning-for-high-risk-prostate-cancer-with-seminal-vesicles
#17
Suresh Rana, ChihYao Cheng, Li Zhao, SungYong Park, Gary Larson, Carlos Vargas, Megan Dunn, Yuanshui Zheng
INTRODUCTION: The purpose of this study was to evaluate the dosimetric and radiobiological impact of intensity modulated proton therapy (IMPT) and RapidArc planning for high-risk prostate cancer with seminal vesicles. METHODS: Ten high-risk prostate cancer cases were included in this retrospective study. For each case, IMPT plans were generated using multiple field optimisation (MFO) technique (two fields) with XiO treatment planning system (TPS), whereas RapidArc plans were generated using double-arc technique (two full arcs) with Eclipse TPS...
March 2017: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/27685114/on-the-use-of-a-convolution-superposition-algorithm-for-plan-checking-in-lung-stereotactic-body-radiation-therapy
#18
Nicholas Hardcastle, Bradley M Oborn, Annette Haworth
Stereotactic body radiation therapy (SBRT) aims to deliver a highly conformal ablative dose to a small target. Dosimetric verification of SBRT for lung tumors presents a challenge due to heterogeneities, moving targets, and small fields. Recent software (M3D) designed for dosimetric verification of lung SBRT treatment plans using an advanced convolution-superposition algorithm was evaluated. Ten lung SBRT patients covering a range of tumor volumes were selected. 3D CRT plans were created using the XiO treatment planning system (TPS) with the superposition algorithm...
September 8, 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27394843/nomenclatural-note-on-the-homonymy-between-the-octocoral-genus-dendrobrachia-brook-1889-and-the-entoproct-phylum-dendrobrachia-xian-guan-bergstr%C3%A3-m-xio-ya-and-jie-2006
#19
Eric Pante
Dendrobrachia was proposed by Xian-Guan et al. (2006) as the name of a new phylum of entoproct-like animals from the Lower Cambrian (Yunnan Province, China). This name was however preoccupied by the octocoral Dendrobrachia Brook 1889, which position within the subclass Octocorallia is currently uncertain (Opresko and Bayer 1991; Berntson et al. 1999, 2001). Based on the principles of homonymy and priority (Articles 52 and 23, respectively; ICZN 1999), a substitute name for the entoproct Dendrobrachia is necessary, and I propose Dendrobrachion (based on the Greek brachion, for arm)...
May 4, 2016: Zootaxa
https://www.readbyqxmd.com/read/26894345/percentage-depth-dose-calculation-accuracy-of-model-based-algorithms-in-high-energy-photon-small-fields-through-heterogeneous-media-and-comparison-with-plastic-scintillator-dosimetry
#20
Ananda Giri Babu Alagar, Ganesh Kadirampatti Mani, Kaviarasu Karunakaran
Small fields smaller than 4 × 4 cm2 are used in stereotactic and conformal treatments where heterogeneity is normally present. Since dose calculation accuracy in both small fields and heterogeneity often involves more discrepancy, algorithms used by treatment planning systems (TPS) should be evaluated for achieving better treatment results. This report aims at evaluating accuracy of four model-based algorithms, X-ray Voxel Monte Carlo (XVMC) from Monaco, Superposition (SP) from CMS-Xio, AcurosXB (AXB) and analytical anisotropic algorithm (AAA) from Eclipse are tested against the measurement...
January 8, 2016: Journal of Applied Clinical Medical Physics
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