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https://www.readbyqxmd.com/read/28330311/scaling-up-a-virginiamycin-production-by-a-high-yield-streptomyces-virginiae-vkm-ac-2738d-strain-using-adsorbing-resin-addition-and-fed-batch-fermentation-under-controlled-conditions
#1
Vakhtang Dzhavakhiya, Vyacheslav Savushkin, Alexander Ovchinnikov, Vladislav Glagolev, Veronika Savelyeva, Evgeniya Popova, Nikita Novak, Elena Glagoleva
Virginiamycin produced by Streptomyces virginiae as a natural mix of macrocyclic peptidolactones M and S is widely used in the industrial production of ethanol fuel and as an antibiotic feed additive for cattle and poultry. Its main antimicrobial components, M1 and S1 factors, act synergistically if the M1:S1 ratio in the final product is 70-75:25-30. This fact significantly complicates the development of stable high-yield strains suitable for industrial application. In the previous work, authors obtained a mutant S...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28327709/fish-oil-supplementation-inhibits-endoplasmic-reticulum-stress-and-improves-insulin-resistance-involvement-of-amp-activated-protein-kinase
#2
Wenqi Yang, Xu Chen, Ming Chen, Yanping Li, Qing Li, Xinwei Jiang, Yan Yang, Wenhua Ling
The beneficial effects of fish oil consumption on glucose metabolism have been generally reported. However, the mechanism underlying the fish oil-induced protective effects against insulin resistance remains unclear. Endoplasmic reticulum (ER) stress is recognized as an important contributor to insulin resistance. The aim of this study is to evaluate whether fish oil supplementation reduces ER stress and ameliorates insulin resistance in diet-induced obese mice, and to investigate the molecular mechanism of fish oil-induced benefits on ER stress...
March 22, 2017: Food & Function
https://www.readbyqxmd.com/read/28325852/extended-multiplexing-of-tmt-labeling-reveals-age-and-high-fat-diet-specific-proteome-changes-in-mouse-epididymal-adipose-tissue
#3
Deanna L Plubell, Phillip A Wilmarth, Yuqi Zhao, Alexandra M Fenton, Jessica Minnier, Ashok P Reddy, John Klimek, Xia Yang, Larry L David, Nathalie Pamir
The lack of high-throughput methods to analyze the adipose tissue protein composition limits our understanding of the protein networks responsible for age and diet related metabolic response. We have developed an approach using multiple-dimension liquid chromatography tandem mass spectrometry and extended multiplexing (24 biological samples) with TMT labeling to analyze proteomes of epididymal adipose tissues isolated from mice fed either low or high fat diet for a short or a long-term, and from mice that aged on low vs...
March 21, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28322071/an-additional-bolus-of-rapid-acting-insulin-to-normalise-postprandial-cardiovascular-risk-factors-following-a-high-carbohydrate-high-fat-meal-in-patients-with-type-1-diabetes-a-randomised-controlled-trial
#4
Matthew D Campbell, Mark Walker, Ramzi A Ajjan, Karen M Birch, Javier T Gonzalez, Daniel J West
AIM: To evaluate an additional rapid-acting insulin bolus on postprandial lipaemia, inflammation and pro-coagulation following high-carbohydrate high-fat feeding in people with type 1 diabetes. METHODS: A total of 10 males with type 1 diabetes [HbA1c 52.5 ± 5.9 mmol/mol (7.0% ± 0.5%)] underwent three conditions: (1) a low-fat (LF) meal with normal bolus insulin, (2), a high-fat (HF) meal with normal bolus insulin and (3) a high-fat meal with normal bolus insulin with an additional 30% insulin bolus administered 3-h post-meal (HFA)...
March 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28320484/nutritional-intervention-preconception-and-during-pregnancy-to-maintain-healthy-glucose-metabolism-and-offspring-health-nipper-study-protocol-for-a-randomised-controlled-trial
#5
Keith M Godfrey, Wayne Cutfield, Shiao-Yng Chan, Philip N Baker, Yap-Seng Chong
BACKGROUND: Improved maternal nutrition and glycaemic control before and during pregnancy are thought to benefit the health of the mother, with consequent benefits for infant body composition and later obesity risk. Maternal insulin resistance and glycaemia around conception and in early pregnancy may be key determinants of maternal physiology and placental function, affecting fetal nutrient supply and maternal-feto-placental communications throughout gestation, with implications for later postnatal health...
March 20, 2017: Trials
https://www.readbyqxmd.com/read/28318397/baiba-does-not-regulate-ucp-3-expression-in-human-skeletal-muscle-as-a-response-to-aerobic-exercise
#6
Flor E Morales, Jeffrey S Forsse, Thomas L Andre, Sarah K McKinley-Barnard, Paul S Hwang, Ian G Anthony, Grant M Tinsley, Mike Spillane, Peter W Grandjean, Alejandro Ramirez, Darryn S Willoughby
OBJECTIVE: β-Aminoisobutyric acid (BAIBA) has shown to modulate uncoupling protein (UCP)-1 expression, which is mainly expressed in white adipose tissue; however, no studies to date have analyzed its potential effect on the main uncoupling protein of skeletal muscle, UCP-3. The main goal of this study was to assess the potential effect of acute aerobic exercise on serum BAIBA and skeletal muscle UCP-3. The secondary goal was to assess the potential involvement of the transcription factors proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and peroxisome proliferator-activated receptor alpha (PPARα), as well as free fatty acids (FFAs) in UCP-3 expression...
March 20, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28315774/molecular-characterization-of-amp-activated-protein-kinase-%C3%AE-2-from-herbivorous-fish-megalobrama-amblycephala-and-responsiveness-to-glucose-loading-and-dietary-carbohydrate-levels
#7
Chao Xu, Wen-Bin Liu, Ding-Dong Zhang, Kai-Zhou Wang, Si-Lei Xia, Xiang-Fei Li
This study aimed to characterize the full-length cDNA of AMPKα2 in Megalobrama amblycephala, and evaluate its potential role in glucose homeostasis and carbohydrate metabolism. The cDNA obtained covered 1942bp with an open reading frame of 1635bp encoding 545 amino acids. Multiple alignments and phylogenetic analysis revealed a high homology (91-100%) among most fish and higher vertebrates. This AMPKα2 mRNA predominantly expressed in muscle, liver and brain, while little in gill and intestine. Then, the AMPKα2 expressions were determined in the muscle, liver and brain of fish subjected to a glucose load (injected intraperitoneally with 0, 1...
March 15, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28315700/exploiting-the-aglycon-promiscuity-of-glycosyltransferase-bs-yjic-from-bacillus-subtilis-and-its-application-in-synthesis-of-glycosides
#8
Longhai Dai, Jiao Li, Peiyuan Yao, Yueming Zhu, Yan Men, Yan Zeng, Jiangang Yang, Yuanxia Sun
Glycosylation is a prominent biological mechanism for structural and functional diversity of natural products. Uridine diphosphate-dependent glycosyltransferases with aglycon promiscuity are generally recognised as effective biocatalysts for glycodiversification of natural products for practical applications. In this study, the aglycon promiscuity of glycosyltransferase Bs-YjiC from Bacillus subtilis 168 was explored. Bs-YjiC, with uridine diphosphate glucose (UDPG) as sugar donor, exhibited robust capabilities to glycosylate 19 structurally diverse types of drug-like scaffolds with regio- and stereospecificities and form O-, N- and S-linkage glycosides...
March 15, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28306532/evaluation-of-the-sub-chronic-toxicity-profile-of-the-corm-of-xanthosoma-sagittifolium-on-hematology-and-biochemistry-of-alloxan-induced-diabetic-wistar-rats
#9
Olayinka A Oridupa, Oluyemisi F Folasire, Adedotun J Owolabi
Background Hematological and biochemical changes associated with diabetes mellitus and probable reversal were assessed in alloxan-induced diabetic Wistar rats fed with varied percentages of Xanthosoma sagittifolium corm feed (Xs). The changes were compared to normoglycemic rats and diabetic rats treated with glibenclamide. Methods The study had eight groups in all with group 8 (control) consisting of five normoglycemic rats fed with normal rat pellets (Nrp). Diabetes was experimentally induced by intraperitoneal injection of alloxan to normoglycemic rats...
March 11, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28302796/an-adipo-biliary-uridine-axis-that-regulates-energy-homeostasis
#10
Yingfeng Deng, Zhao V Wang, Ruth Gordillo, Yu An, Chen Zhang, Qiren Liang, Jun Yoshino, Kelly M Cautivo, Jef De Brabander, Joel K Elmquist, Jay D Horton, Joseph A Hill, Samuel Klein, Philipp E Scherer
Uridine, a pyrimidine nucleoside present at high levels in the plasma of rodents and humans, is critical for RNA synthesis, glycogen deposition, and many other essential cellular processes. It also contributes to systemic metabolism, but the underlying mechanisms remain unclear. We found that plasma uridine levels are regulated by fasting and refeeding in mice, rats, and humans. Fasting increases plasma uridine levels, and this increase relies largely on adipocytes. In contrast, refeeding reduces plasma uridine levels through biliary clearance...
March 17, 2017: Science
https://www.readbyqxmd.com/read/28300010/effect-of-dietary-supplementation-of-ligustrum-lucidum-on-performance-egg-quality-and-blood-biochemical-parameters-of-hy-line-brown-hens-during-the-late-laying-period
#11
X L Li, W L He, M L Yang, Y M Yan, Y H Xue, S T Zhao
The fruit of Ligustrum lucidum (FLL, Nuzhenzi in Chinese) is an important traditional medicine, and have attracted significant research attention because of their various biological activities. However, there are few research reports available on the use of FLL as a feed additive in livestock nutrition, particularly in layers. This study was conducted to determine the effects of supplementation of the diet of laying hens with FLL on laying performance, egg quality and blood metabolites. A total of 360 72-week-old hens were allocated to three dietary treatments (eight replications of 15 hens/treatment group) and were fed either a control diet or a diet supplemented with an inclusion level of 0...
March 16, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28299572/early-weight-loss-independent-effects-of-sleeve-gastrectomy-on-diet-induced-cardiac-dysfunction-in-obese-wistar-rats
#12
Tammy L Kindel, Tom Foster, Paul Goldspink, Steven J Kindel, John Corbett, Michael Widlanksy, Jennifer Strande
INTRODUCTION: Several reports suggest that bariatric surgery significantly improves cardiac function in patients with obesity cardiomyopathy. The mechanism is unknown but may be due to weight-loss independent factors. We predict that the changes in gastrointestinal anatomy after a rodent model of sleeve gastrectomy (SG) will have weight-loss independent effects on cardiac dysfunction. METHODOLOGY: Cardiac dysfunction was induced by feeding a 60% kcal from fat diet to male Wistar rats for 10 weeks...
March 15, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28299315/rna-based-stable-isotope-probing-suggests-allobaculum-spp-as-particularly-active-glucose-assimilators-in-a-complex-murine-microbiota-cultured-in-vitro
#13
Elena Herrmann, Wayne Young, Douglas Rosendale, Verena Reichert-Grimm, Christian U Riedel, Ralf Conrad, Markus Egert
RNA-based stable isotope probing (RNA-SIP) and metabolic profiling were used to detect actively glucose-consuming bacteria in a complex microbial community obtained from a murine model system. A faeces-derived microbiota was incubated under anaerobic conditions for 0, 2, and 4 h with 40 mM [U(13)C]glucose. Isopycnic density gradient ultracentrifugation and fractionation of isolated RNA into labeled and unlabeled fractions followed by 16S rRNA sequencing showed a quick adaptation of the bacterial community in response to the added sugar, which was dominated by unclassified Lachnospiraceae species...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28299204/the-coadministration-of-unoxidized-and-oxidized-desi-ghee-ameliorates-the-toxic-effects-of-thermally-oxidized-ghee-in-rabbits
#14
Alam Zeb, Islam Uddin
Desi Ghee was thermally oxidized at 160°C for 9 h and characterized for peroxide value (PV), free fatty acid (FFA), thiobarbituric acid reactive substances (TBARS), radical scavenging activity (RSA), and fatty acid and cholesterol composition using GC-MS. Oxidized (OG) and normal ghee (NG) were fed to rabbits in different doses. Blood was collected for hematology and biochemical analyses after 7 and 14 days. The oxidation of desi ghee increased the PV, FFA, and TBARS values and showed a decline in the RSA values...
2017: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/28298682/effect-of-spray-drying-on-physical-properties-of-sugarcane-juice-powder-saccharum-officinarum-l
#15
Jyoti Nishad, Cynthia J Selvan, Shabir Ahmad Mir, Sowriappan John Don Bosco
The aim of the present study was to investigate the spray drying behavior of sugarcane juice with (PSJ) and without (CSJ) citric acid the effects of different levels (10-50%) of carrier agents (maltodextrin (MD), Gum Arabic, liquid glucose and carrot fiber) at varying operating conditions of inlet and outlet temperature and feed concentration during spray drying was also studied. Spray dried powders from PSJ and CSJ were analyzed for physical properties such as wettability, cohesiveness, dispersibility, flowability, hygroscopicity, particle morphology etc...
March 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28298535/resistant-starch-but-not-enzymatically-modified-waxy-maize-delays-development-of-diabetes-in-zucker-diabetic-fatty-rats
#16
Mette Skou Hedemann, Kjeld Hermansen, Sven Pedersen, Knud Erik Bach Knudsen
Background: The incidence of type 2 diabetes (T2D) is increasing worldwide, and nutritional management of circulating glucose may be a strategic tool in the prevention of T2D.Objective: We studied whether enzymatically modified waxy maize with an increased degree of branching delayed the onset of diabetes in male Zucker diabetic fatty (ZDF) rats.Methods: Forty-eight male ZDF rats, aged 5 wk, were divided into 4 groups and fed experimental diets for 9 wk that contained 52.95% starch: gelatinized corn starch (S), glucidex (GLU), resistant starch (RS), or enzymatically modified starch (EMS)...
March 15, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28296355/biosensor-enabled-directed-evolution-to-improve-muconic-acid-production-in-saccharomyces-cerevisiae
#17
John M Leavitt, James M Wagner, Cuong Chi Tu, Alice Tong, Yanyi Liu, Hal S Alper
Muconic acid is a valuable platform chemical with potential applications in the production of polymers such as nylon and polyethylene terephthalate (PET). The conjugate base, muconate, was previously biosynthesized in the bacterial host Escherichia coli. Significant pathway engineering led to the first reported instance of rationally engineered production of muconic acid in the yeast Saccharomyces cerevisiae. To further increase muconic acid production in this host, we employed an adaptive laboratory evolution (ALE) strategy to complement rational metabolic engineering...
March 10, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28295656/effect-of-dietary-polyphenol-rich-grape-seed-on-growth-performance-antioxidant-capacity-and-ileal-microflora-in-broiler-chicks
#18
S H Abu Hafsa, S A Ibrahim
In this study, we examined the effect of dietary supplementation with grape seed (GS) on the performance, carcass traits, plasma biochemistry, antioxidant status and ileal microflora in broilers. Experiment diets included a control diet (without additive) and three levels of GS powder (10, 20 and 40 g/kg of diet). Each diet was fed to a total of 300 one-day-old Cobb-500 chicks for 42 days. The addition of 20 g/kg of GS to the basal diet increased final body weight and body weight gain, improved the feed conversion ratio and did not affect feed intake...
March 15, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28293757/glucose-variability-measures-as-predictors-of-oral-feeding-intolerance-in-acute-pancreatitis-a-prospective-pilot-study
#19
Chirag J Jivanji, Varsha M Asrani, Sayali A Pendharkar, Melody G Bevan, Nicola A Gillies, Danielle H E Soo, Ruma G Singh, Maxim S Petrov
BACKGROUND: Oral feeding intolerance (OFI) is a common complication in patients with acute pancreatitis (AP). Variations in blood glucose are associated with impaired gastrointestinal function but, to date, measures of glucose variability have not been investigated to predict OFI in patients with AP. AIM: To investigate the usefulness of several glucose variability measures in predicting the occurrence of OFI early in the course of AP. METHODS: In this prospective cohort study, six measures of glucose variability were calculated prior to the occurrence of OFI...
March 14, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28292516/speedy-standing-wave-design-optimization-and-scaling-rules-of-simulated-moving-bed-systems-with-linear-isotherms
#20
George S Weeden, Nien-Hwa Linda Wang
Simulated Moving Bed (SMB) systems with linear adsorption isotherms have been used for many different separations, including large-scale sugar separations. While SMBs are much more efficient than batch operations, they are not widely used for large-scale production because there are two key barriers. The methods for design, optimization, and scale-up are complex for non-ideal systems. The Speedy Standing Wave Design (SSWD) is developed here to reduce these barriers. The productivity (PR) and the solvent efficiency (F/D) are explicitly related to seven material properties and 13 design parameters...
February 22, 2017: Journal of Chromatography. A
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