Jianqing She, Gulinigaer Tuerhongjiang, Manyun Guo, Junhui Liu, Xiang Hao, Liangan Guo, Nairong Liu, Wen Xi, Tao Zheng, Bin Du, Bowen Lou, Xiyu Gao, Xiao Yuan, Yue Yu, Yi Zhang, Fan Gao, Xiaozhen Zhuo, Ying Xiong, Xiang Zhang, Jun Yu, Zuyi Yuan, Yue Wu
Statins are currently the most common cholesterol-lowering drug, but the underlying mechanism of statin-induced hyperglycemia is unclear. To investigate whether the gut microbiome and its metabolites contribute to statin-associated glucose intolerance, we recruited 30 patients with atorvastatin and 10 controls, followed up for 16 weeks, and found a decreased abundance of the genus Clostridium in feces and altered serum and fecal bile acid profiles among patients with atorvastatin therapy. Animal experiments validated that statin could induce glucose intolerance, and transplantation of Clostridium sp...
February 6, 2024: Cell Metabolism