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https://www.readbyqxmd.com/read/27885436/effects-of-aluminum-trichloride-on-the-cartilage-stimulatory-growth-factors-in-rats
#1
Fan Zhang, Xudong Sun, Hongyan Yu, Xu Yang, Miao Song, Yanfei Han, Yanfei Li, Yanzhu Zhu
Aluminum (Al) is considered to be a potentially toxic metal and inhibits cartilage formation. Transforming growth factor β1 (TGF-β1) and bone morphogenetic protein 2 (BMP-2) are cartilage stimulatory growth factors, which play important roles in regulating the cartilage formation. To investigate the effects of aluminum trichloride (AlCl3) on the regulation of cartilage formation. Eighty Wistar rats were orally exposed to 0 (control group), 0.4 g/L (low-dose group), 0.8 g/L (mid-dose group) and 1.6 g/L (high-dose group) AlCl3 for 120 days, respectively...
November 24, 2016: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/27875417/the-utility-of-routinely-obtaining-postoperative-laboratory-studies-following-a-minimally-invasive-transforaminal-lumbar-interbody-fusion
#2
Junyoung Ahn, Dustin H Massel, Benjamin C Mayo, Fady Y Hijji, Ankur S Narain, Khaled Aboushaala, Daniel D Bohl, Islam M Elboghdady, Jacob V DiBattista, Kern Singh
STUDY DESIGN: This is a retrospective analysis. OBJECTIVE: To test the hypothesis that there is limited utility in routinely obtaining postoperative laboratory values following minimally invasive transforaminal lumbar interbody fusion (MIS TLIF). BACKGROUND DATA: At many institutions, it is routine to obtain a complete blood count and basic metabolic profile (BMP) following a MIS TLIF. However, the utility of this practice has not been well characterized...
November 21, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27852910/intraosseous-injection-of-simvastatin-in-poloxamer-407-hydrogel-improves-pedicle-screw-fixation-in-ovariectomized-minipigs
#3
X Fu, J Tan, C G Sun, H J Leng, Y S Xu, C L Song
BACKGROUND: Osteoporosis leads to poor osseointegration and reduces implant stability. Statins have been found to stimulate bone formation, but the bioavailability from oral administration is low. Local application may be more effective at augmenting bone formation and enhancing implant stability. This study was performed to evaluate the efficacy of an intraosseous injection of simvastatin in thermosensitive poloxamer 407 hydrogel to enhance pedicle-screw fixation in calcium-restricted ovariectomized minipigs...
November 16, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27770964/strategies-for-delivering-bone-morphogenetic-protein-for-bone-healing
#4
Howa Begam, Samit Kumar Nandi, Biswanath Kundu, Abhijit Chanda
Bone morphogenetic proteins (BMPs) are the most significant growth factors that belong to the Transforming Growth Factor Beta (TGF-β) super-family. Though more than twenty members of this family have been identified so far in humans, Food and Drug Administration (FDA) approved two growth factors: BMP-2 and BMP-7 for treatments of spinal fusion and long-bone fractures with collagen carriers. Currently BMPs are clinically used in spinal fusion, oral and maxillofacial surgery and also in the repair of long bone defects...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27630576/morn5-expression-during-craniofacial-development-and-its-interaction-with-the-bmp-and-tgf%C3%AE-pathways
#5
Petra Cela, Marek Hampl, Katherine K Fu, Michaela Kunova Bosakova, Pavel Krejci, Joy M Richman, Marcela Buchtova
MORN5 (MORN repeat containing 5) is encoded by a locus positioned on chromosome 17 in the chicken genome. The MORN motif is found in multiple copies in several proteins including junctophilins or phosphatidylinositol phosphate kinase family and the MORN proteins themselves are found across the animal and plant kingdoms. MORN5 protein has a characteristic punctate pattern in the cytoplasm in immunofluorescence imaging. Previously, MORN5 was found among differentially expressed genes in a microarray profiling experiment of the chicken embryo head...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27504532/growth-factors-in-bone-marrow-blood-of-the-mandible-with-application-of-extracorporeal-shock-wave-therapy
#6
Jacqueline A Pfaff, Birgit Boelck, Wilhelm Bloch, Georg-Hubertus Nentwig
INTRODUCTION: Enhancement of bone regeneration is crucial to dental implantology. Growth factors play a significant role during osteogenesis and angiogenesis. Extracorporeal shock wave therapy (ESWT) enhances bone healing; however, no studies have yet been performed in oral implantology. MATERIALS AND METHODS: Twenty patients who underwent bilateral mandibular wisdom tooth removal were included. ESWT was applied to 1 side of the jaw. Blood samples were collected from the peripheral vein (PB), mandibular bone marrow without and with ESWT (BM-/+SW)...
October 2016: Implant Dentistry
https://www.readbyqxmd.com/read/27316792/a-neoflavonoid-dalsissooal-isolated-from-heartwood-of-dalbergia-sissoo-roxb-has-bone-forming-effects-in-mice-model-for-osteoporosis
#7
Priyanka Kushwaha, Vikram Khedgikar, Naseer Ahmad, Anirudha Karvande, Jyoti Gautam, Padam Kumar, Rakesh Maurya, Ritu Trivedi
Dalbergia sissoo Roxb. is a well known medicinal plant of India, enriched with various flavonoids used for treating multiple diseases. Earlier, we have shown that extract of Dalbergia sissoo Roxb. leaves mitigate ovariectomy induced bone loss and pure compounds (neoflavonoids) isolated from it, promote osteoblastogenesis in primary calvarial osteoblasts cells in vitro. Here, we hypothesize that dalsissooal (DSL), a novel neoflavonoid isolated from the heartwood of Dalbergia sissoo Roxb. is an important constituent of the extract that imparts bone forming effects...
October 5, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27212154/injectable-bioactive-glass-in-the-restoration-of-oral-bone-defect
#8
C-B Han, S-C An
OBJECTIVE: To explore the application value of injectable bioactive glass in the restoration of the oral bone defect. PATIENTS AND METHODS: This study included 58 consecutive patients with oral bone defect > 1 mm, these patients were randomly assigned to a control group (n=26, Hydroxyapatite bioceramics) and an observation group (n=32, Injectable bioactive glass). The purpose of this study was to assess the comparison of the healing of oral bone defect. RESULTS: X-ray examination was performed at 6-month and 12-month following treatment...
May 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27199755/the-role-of-butylidenephthalide-in-targeting-the-microenvironment-which-contributes-to-liver-fibrosis-amelioration
#9
Hong-Meng Chuang, Hong-Lin Su, Chien Li, Shinn-Zong Lin, Ssu-Yin Yen, Mao-Hsuan Huang, Li-Ing Ho, Tzyy-Wen Chiou, Horng-Jyh Harn
The treatment of liver fibrosis has clinical limitations because of its multiple etiologies, such as epithelial-mesenchymal transition (EMT) promotion, cell regeneration and remodeling dysfunction, inflammatory cell activation, and scar tissue deposition. These factors might be considered as a new target for the fibrotic microenvironment, leading to increased fibrogenesis and liver fibrosis. Here, we investigate a small molecule named butylidenephthalide (BP) and its multiple effects on liver fibrosis treatment...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27178636/root-bark-of-sambucus-williamsii-hance-promotes-rat-femoral-fracture-healing-by-the-bmp-2-runx2-signaling-pathway
#10
Bingyou Yang, Xiaoying Lin, Jinyan Tan, Xian She, Yan Liu, Haixue Kuang
ETHNOPHARMACOLOGICAL RELEVANCE: Sambucus Williamsii Hance (SWH) is a plant from a family of Caprifoliaceae, which has a long medical history of use as an effective folk treatment for fracture bruises. AIM OF THE STUDY: To evaluate the effects of 50% ethanol extracts of root-bark of Sambucus Williamsii Hance(EE-rbSWH) on fracture healing of rats and explore its mechanism of actions related to the BMP-2 signaling pathway. MATERIALS AND METHODS: EE-rbSWH was orally administered at the doses of 340 and 680mg/kg to adult Sprague-Dawley rats with operation of open femur fracture completely for 2, 4 and 8 weeks...
September 15, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27108402/nanodiamond-modified-copolymer-scaffolds-affects-tumour-progression-of-early-neoplastic-oral-keratinocytes
#11
Salwa Suliman, Kamal Mustafa, Anke Krueger, Doris Steinmüller-Nethl, Anna Finne-Wistrand, Tereza Osdal, Amani O Hamza, Yang Sun, Himalaya Parajuli, Thilo Waag, Joachim Nickel, Anne Christine Johannessen, Emmet McCormack, Daniela Elena Costea
This study aimed to evaluate the tumorigenic potential of functionalising poly(LLA-co-CL) scaffolds. The copolymer scaffolds were functionalised with nanodiamonds (nDP) or with nDP and physisorbed BMP-2 (nDP-PHY) to enhance osteoinductivity. Culturing early neoplastic dysplastic keratinocytes (DOK(Luc)) on nDP modified scaffolds reduced significantly their subsequent sphere formation ability and decreased significantly the cells' proliferation in the supra-basal layers of in vitro 3D oral neoplastic mucosa (3D-OT) when compared to DOK(Luc) previously cultured on nDP-PHY scaffolds...
July 2016: Biomaterials
https://www.readbyqxmd.com/read/27098389/is-heparin-effective-for-the-controlled-delivery-of-high-dose-bone-morphogenetic-protein-2
#12
Ri Youn Kim, Beomseok Lee, Si-Nae Park, Jae-Hyung Ko, In Sook Kim, Soon Jung Hwang
Sustained release of bone morphogenetic protein (BMP)-2 by heparin-contained biomaterials is advantageous for bone tissue regeneration using low-dose BMP-2. However, its effect with high-dose BMP-2 is still unclear and should be clarified considering the clinical use of a high dose of BMP-2 in spine and oral surgery. This study aimed to evaluate the efficacy of a heparin-conjugated collagen sponge (HCS) with high-dose BMP-2 delivery by investigating in vivo initial osteogenic regulation and bone healing over 12 weeks in comparison with that of an absorbable collagen sponge (ACS)...
May 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27070559/effects-of-phlomis-umbrosa-root-on-longitudinal-bone-growth-rate-in-adolescent-female-rats
#13
Donghun Lee, Young-Sik Kim, Jungbin Song, Hyun Soo Kim, Hyun Jung Lee, Hailing Guo, Hocheol Kim
This study aimed to investigate the effects of Phlomis umbrosa root on bone growth and growth mediators in rats. Female adolescent rats were administered P. umbrosa extract, recombinant human growth hormone or vehicle for 10 days. Tetracycline was injected intraperitoneally to produce a glowing fluorescence band on the newly formed bone on day 8, and 5-bromo-2'-deoxyuridine was injected to label proliferating chondrocytes on days 8-10. To assess possible endocrine or autocrine/paracrine mechanisms, we evaluated insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3) or bone morphogenetic protein-2 (BMP-2) in response to P...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27066482/wnt-%C3%AE-catenin-regulates-the-activity-of-epiprofin-sp6-shh-fgf-and-bmp-to-coordinate-the-stages-of-odontogenesis
#14
Maitane Aurrekoetxea, Igor Irastorza, Patricia García-Gallastegui, Lucia Jiménez-Rojo, Takashi Nakamura, Yoshihiko Yamada, Gaskon Ibarretxe, Fernando J Unda
BACKGROUND: We used an in vitro tooth development model to investigate the effects of overactivation of the Wnt/β-catenin pathway during odontogenesis by bromoindirubin oxime reagent (BIO), a specific inhibitor of GSK-3 activity. RESULTS: Overactivating the Wnt/β-catenin pathway at tooth initiation upregulated and ectopically expressed the epithelial markers Sonic Hedgehog (Shh), Epiprofin (Epfn), and Fibroblast growth factor8 (Fgf8), which are involved in the delimitation of odontogenic fields in the oral ectoderm...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/27039814/recombinant-human-bone-morphogenetic-protein-2-in-development-and-progression-of-oral-squamous-cell-carcinoma
#15
Khaled Waleed Zaid, Mansour Chantiri, Ghassan Bassit
Bone morphogenetic proteins (BMPs), belonging to the transforming growth factor-β superfamily, regulate many cellular activities including cell migration, differentiation, adhesion, proliferation and apoptosis. Use of recombinant human bone morphogenic protein?2 (rhBMP?2) in oral and maxillofacial surgery has seen a tremendous increase. Due to its role in many cellular pathways, the influence of this protein on carcinogenesis in different organs has been intensively studied over the past decade. BMPs also have been detected to have a role in the development and progression of many tumors, particularly disease-specific bone metastasis...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27012621/the-dietary-flavonoid-myricetin-regulates-iron-homeostasis-by-suppressing-hepcidin-expression
#16
Mingdao Mu, Peng An, Qian Wu, Xiaoyun Shen, Dandan Shao, Hao Wang, Yingqi Zhang, Shenshen Zhang, Hui Yao, Junxia Min, Fudi Wang
Hepcidin, a master regulator of iron homeostasis, is a promising target in treatment of iron disorders such as hemochromatosis, anemia of inflammation and iron-deficiency anemia. We previously reported that black soybean seed coat extract could inhibit hepcidin expression. Based on this finding, we performed a screen in cultured cells in order to identify the compounds in black soybeans that inhibit hepcidin expression. We found that the dietary flavonoid myricetin significantly inhibited the expression of hepcidin both in vitro and in vivo...
April 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/26973535/epidemiology-etiology-and-treatment-of-isolated-cleft-palate
#17
REVIEW
Madeleine L Burg, Yang Chai, Caroline A Yao, William Magee, Jane C Figueiredo
Isolated cleft palate (CPO) is the rarest form of oral clefting. The incidence of CPO varies substantially by geography from 1.3 to 25.3 per 10,000 live births, with the highest rates in British Columbia, Canada and the lowest rates in Nigeria, Africa. Stratified by ethnicity/race, the highest rates of CPO are observed in non-Hispanic Whites and the lowest in Africans; nevertheless, rates of CPO are consistently higher in females compared to males. Approximately fifty percent of cases born with cleft palate occur as part of a known genetic syndrome or with another malformation (e...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/26917158/genetically-engineered-flavonol-enriched-tomato-fruit-modulates-chondrogenesis-to-increase-bone-length-in-growing-animals
#18
Dharmendra Choudhary, Ashutosh Pandey, Sulekha Adhikary, Naseer Ahmad, Chitra Bhatia, Sweta Bhambhani, Prabodh Kumar Trivedi, Ritu Trivedi
Externally visible body and longitudinal bone growth is a result of proliferation of chondrocytes. In growth disorder, there is delay in the age associated increase in height. The present study evaluates the effect of extract from transgenic tomato fruit expressing AtMYB12 transcription factor on bone health including longitudinal growth. Constitutive expression of AtMYB12 in tomato led to a significantly enhanced biosynthesis of flavonoids in general and the flavonol biosynthesis in particular. Pre-pubertal ovary intact BALB/c mice received daily oral administration of vehicle and ethanolic extract of wild type (WT-TOM) and transgenic AtMYB12-tomato (MYB12-TOM) fruits for six weeks...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26865041/bizarre-parosteal-osteochondromatous-proliferation-in-the-lingual-area-of-the-mandibular-body-versus-osteochondroma-at-the-mandibular-condyle
#19
Soung Min Kim, Hoon Myoung, Sang Shin Lee, Yeon Sook Kim, Suk Keun Lee
BACKGROUND: Bizarre parosteal osteochondromatous proliferation (BPOP) is benign and usually occurs in the small tubular bones of the hands and feet, but it is extremely rare in the oral and maxillofacial region. METHODS: The present study compares a case of BPOP occurring in the lingual area of the right mandibular body with a representative case of osteochondroma occurring in the left mandibular condyle using immunohistochemical methods. RESULTS: BPOP showed no continuity to the cortical bone of the mandible on X-ray and was histologically composed of immature cartilage and bone tissues, whereas osteochondroma showed overgrowth of hypertrophic chondrocytes accompanied by mature bone with endochondral ossification...
2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26845577/an-ancient-dental-gene-set-governs-development-and-continuous-regeneration-of-teeth-in-sharks
#20
Liam J Rasch, Kyle J Martin, Rory L Cooper, Brian D Metscher, Charlie J Underwood, Gareth J Fraser
The evolution of oral teeth is considered a major contributor to the overall success of jawed vertebrates. This is especially apparent in cartilaginous fishes including sharks and rays, which develop elaborate arrays of highly specialized teeth, organized in rows and retain the capacity for life-long regeneration. Perpetual regeneration of oral teeth has been either lost or highly reduced in many other lineages including important developmental model species, so cartilaginous fishes are uniquely suited for deep comparative analyses of tooth development and regeneration...
July 15, 2016: Developmental Biology
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