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https://www.readbyqxmd.com/read/28545172/femoral-nerve-block-versus-adductor-canal-block-for-analgesia-after-total-knee-arthroplasty
#1
REVIEW
In Jun Koh, Young Jun Choi, Man Soo Kim, Hyun Jung Koh, Min Sung Kang, Yong In
Inadequate pain management after total knee arthroplasty (TKA) impedes recovery, increases the risk of postoperative complications, and results in patient dissatisfaction. Although the preemptive use of multimodal measures is currently considered the principle of pain management after TKA, no gold standard pain management protocol has been established. Peripheral nerve blocks have been used as part of a contemporary multimodal approach to pain control after TKA. Femoral nerve block (FNB) has excellent postoperative analgesia and is now a commonly used analgesic modality for TKA pain control...
June 1, 2017: Knee Surgery & related Research
https://www.readbyqxmd.com/read/28545163/coccygeal-body-revisited-an-immunohistochemical-study-using-donated-elderly-cadavers
#2
Zhe Wu Jin, Kwang Ho Cho, Hyung Suk Jang, Gen Murakami, Jose Francisco Rodríguez-Vázquez, Masahito Yamamoto, Shin-Ichi Abe
To describe the normal anatomy and histology of the adult coccygeal body (CB) and to discuss about the origin and function. Using immunohistochemistry, we examined 29 CBs found in 32 elderly donated cadavers without macroscopic pathology in the pelvis. The CB was usually located in or near the anococcygeal ligaments. It was almost always composed of multiple masses or nodules of round glomus cells (smooth muscle actin, or SMA++). However, the CB sometimes contained abundant dilated veins with scattered glomus cells...
May 25, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28544784/presynaptic-congenital-myasthenic-syndrome-with-a-homozygous-sequence-variant-in-lama5-combines-myopia-facial-tics-and-failure-of-neuromuscular-transmission
#3
Ricardo A Maselli, Juan Arredondo, Jessica Vázquez, Jessica X Chong, Michael J Bamshad, Deborah A Nickerson, Marian Lara, Fiona Ng, Victoria L Lo, Peter Pytel, Craig M McDonald
Defects in genes encoding the isoforms of the laminin alpha subunit have been linked to various phenotypic manifestations, including brain malformations, muscular dystrophy, ocular defects, cardiomyopathy, and skin abnormalities. We report here a severe defect of neuromuscular transmission in a consanguineous patient with a homozygous variant in the laminin alpha-5 subunit gene (LAMA5). The variant c.8046C>T (p.Arg2659Trp) is rare and has a predicted deleterious effect. The affected individual, who also carries a rare homozygous sequence variant in LAMA1, had muscle weakness, myopia, and facial tics...
May 25, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28544582/evaluation-by-medical-students-of-the-educational-value-of-multi-material-and-multi-colored-three-dimensional-printed-models-of-the-upper-limb-for-anatomical-education
#4
Sreenivasulu Reddy Mogali, Wai Yee Yeong, Heang Kuan Joel Tan, Gerald Jit Shen Tan, Peter H Abrahams, Nabil Zary, Naomi Low-Beer, Michael Alan Ferenczi
For centuries, cadaveric material has been the cornerstone of anatomical education. For reasons of changes in curriculum emphasis, cost, availability, expertise, and ethical concerns, several medical schools have replaced wet cadaveric specimens with plastinated prosections, plastic models, imaging, and digital models. Discussions about the qualities and limitations of these alternative teaching resources are on-going. We hypothesize that three-dimensional printed (3DP) models can replace or indeed enhance existing resources for anatomical education...
May 19, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/28544569/maintenance-of-the-contractile-phenotype-in-corpus-cavernosum-smooth-muscle-cells-by-myocardin-gene-therapy-ameliorates-erectile-dysfunction-in-bilateral-cavernous-nerve-injury-rats
#5
H-B Zhang, Z-Q Wang, F-Z Chen, W Ding, W-B Liu, Z-R Chen, S-H He, A-Y Wei
The pathophysiology of erectile dysfunction post radical prostatectomy is not clearly clarified, and the low efficacy of traditional PDE5i treatment remains a major complaint in contemporary practice. This study aimed to demonstrate phenotypic modulation in bilateral cavernous nerve injury (BCNI) rats within 7 days, and subsequently validate gene therapy with Myocardin (Mycod) by maintaining a contractile phenotype in corpus cavernosum smooth muscle cells. Initially, 36 male rats were randomly divided into BCNI and negative control (NC) groups for histological and phenotypic molecular measurements at 3, 5, and 7 days...
May 23, 2017: Andrology
https://www.readbyqxmd.com/read/28544074/single-stage-aesthetic-and-functional-reconstruction-of-composite-facial-gunshot-wound-with-a-chimeric-functioning-muscle-and-fibular-osseous-flap-case-report-and-review-of-the-literature
#6
Andreas Gravvanis, Konstantinos Apostolou, Dimitrios Anterriotis, Dimosthenis Tsoutsos
The current concepts in the aesthetic and functional reconstruction of complex oromandibular defects are presented with a case of a patient with self-inflicted gunshot wound to the face. The patient presented with a 6 cm composite mandibular defect; the buccomandibular and suborbital aesthetic zones of the cheek along with the mucosa lining, and the ipsilateral facial musculature were missing. A rapid prototyping model of the facial skeleton was used to assist in preoperative planning. A single stage reconstruction with two free flaps was planned; a free fibula osseous flap to reconstruct the mandibular defect, and a free chimeric ALT/functioning vastus lateralis muscle...
May 23, 2017: Microsurgery
https://www.readbyqxmd.com/read/28543879/vglut1-synapses-and-p-boutons-on-regenerating-motoneurons-after-nerve-crush
#7
Adam J Schultz, Travis M Rotterman, Anirudh Dwarakanath, Francisco J Alvarez
Stretch-sensitive Ia afferent monosynaptic connections with motoneurons form the stretch reflex circuit. After nerve transection, Ia afferent synapses and stretch reflexes are permanently lost, even after regeneration and efficient re-innervation of muscle by motor and sensory afferents is completed in the periphery. This loss greatly affects full recovery of motor function. However, after nerve crush, reflex muscle forces during stretch do recover after muscle reinnervation and reportedly exceed 140% baseline values...
May 20, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28543038/central-voice-production-and-pathophysiology-of-spasmodic-dysphonia
#8
REVIEW
Niv Mor, Kristina Simonyan, Andrew Blitzer
OBJECTIVE: Our ability to speak is complex, and the role of the central nervous system in controlling speech production is often overlooked in the field of otolaryngology. In this brief review, we present an integrated overview of speech production with a focus on the role of central nervous system. The role of central control of voice production is then further discussed in relation to the potential pathophysiology of spasmodic dysphonia (SD). DATA SOURCES: Peer-review articles on central laryngeal control and SD were identified from PUBMED search...
May 23, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28542067/grb2-associated-binder-1-is-required-for-extrafusal-and-intrafusal-muscle-fiber-development
#9
So Y Park, So Y Jang, Yoon K Shin, Byeol A Yoon, Hye J Lee, Hwan T Park
The neuregulin-1 (NRG1) signaling pathway plays an important role in the development of the peripheral neuromuscular system, including in muscle spindle and postnatal myelination. We previously showed that NRG1 on the axonal membrane regulates peripheral nerve myelination through Grb2-associated binder 1 (Gab1), a scaffolding mediator of receptor tyrosine kinase signaling. Here, we determined the role of Gab1 in the development of muscles and the muscle spindle using muscle-specific conditional Gab1 knockout mice...
May 24, 2017: Neuroreport
https://www.readbyqxmd.com/read/28540442/outcome-after-brachial-plexus-injury-surgery-and-impact-on-quality-of-life
#10
Lukas Rasulić, Andrija Savić, Bojana Živković, Filip Vitošević, Mirko Mićović, Vladimir Baščarević, Vladimir Puzović, Nenad Novaković, Milan Lepić, Miroslav Samardžić, Stefan Mandić-Rajčević
BACKGROUND: The aim of this study was to investigate outcomes after surgery for brachial plexus injury (BPI), not only motor outcomes but also the quality of life of the patients. METHODS: We operated on 128 consecutive patients with BPI from 1992 to 2012. We documented the information on the injured nerve, level of injury, type of treatment used, timing of surgery, patient age, and preoperative and postoperative motor deficits. In 69 patients who agreed to participate in a quality of life study, additional assessments included functionality, pain, quality of life, patient satisfaction, and psychosocial health...
May 24, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28539643/myostatin-a-profibrotic-factor-and-the-main-inhibitor-of-striated-muscle-mass-is-present-in-the-penile-and-vascular-smooth-muscle
#11
I Kovanecz, M Masouminia, R Gelfand, D Vernet, J Rajfer, N F Gonzalez-Cadavid
Myostatin is present in striated myofibers but, except for myometrial cells, has not been reported within smooth muscle cells (SMC). We investigated in the rat whether myostatin is present in SMC within the penis and the vascular wall and, if so, whether it is transcriptionally expressed and associated with the loss of corporal SMC occurring in certain forms of erectile dysfunction (ED). Myostatin protein was detected by immunohistochemistry/fluorescence and western blots in the perineal striated muscles, and also in the SMC of the penile corpora, arteries and veins, and aorta...
May 25, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/28539391/reevaluation-of-reflex-responses-of-the-human-masseter-muscle-to-electrical-lip-stimulation
#12
Paulius Uginčius, Gizem Yilmaz, Oguz Sebik, Kemal Sitki Turker
We examined the reflex response of the human masseter muscle to electrical stimulation of the lip using both single motor unit and surface electromyogram based methods. Using the classical analysis methods, reflex response to mild electrical stimuli generated two distinct short-lasting inhibitions. This pattern may reflect the development of combinations of short and long latency inhibitory postsynaptic potentials as a result of the mildly painful electrical lip stimulation. However, this pattern appearing in the classical analysis methods may have developed as a consequence of earlier responses and may not be genuine...
May 24, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28538831/effects-of-laryngeal-manual-therapy-lmt-and-transcutaneous-electrical-nerve-stimulation-tens-in-vocal-folds-diadochokinesis-of-dysphonic-women-a-randomized-clinical-trial
#13
Larissa Thaís Donalonso Siqueira, Kelly Cristina Alves Silverio, Alcione Ghedini Brasolotto, Rinaldo Roberto de Jesus Guirro, Christiano Giácomo Carneiro, Mara Behlau
Purpose: To verify and compare the effect of transcutaneous electrical nerve stimulation (TENS) and laryngeal manual therapy (LMT) on laryngeal diadochokinesis (DDK) of dysphonic women. Methods: Twenty women with bilateral vocal nodules participated and were equally divided into: LMT Group - LMT application; TENS Group - TENS application; both groups received 12 sessions of treatment, twice a week, with a duration of 20 minutes each, applied by the same therapist...
May 15, 2017: CoDAS
https://www.readbyqxmd.com/read/28538803/comparative-study-between-standard-and-inside-out-vein-graft-techniques-on-sciatic-nerve-repair-of-rats-muscular-and-functional-analysis
#14
Cleuber Rodrigo de Souza Bueno, Mizael Pereira, Idvaldo Aparecido, Rogerio Leone Buchaim, Jesus Carlos Andreo, Antônio de Castro Rodrigues, Geraldo Marco
Purpose: To compare the functional result of standart vein grafts and inside-out vein graft technique on sciatic nerve repair. Methods: We used 24 male Wistar rats divided into 4 groups: control group (CG), standard vein graft group (SVG), Inside-out vein graft group (IOVG) and denervated Group (DG). SVG, IOVG and DG underwent total section of the sciatic nerve, SVG and IOVG however underwent nerve repair surgery using a graft with normal jugular vein and inside-out jugular vein, respectively...
April 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28538571/angiosome-based-allografts-vascularized-composite-allotransplantation-for-tailored-subunit-reconstruction-with-volkmann-ischemic-contracture-as-a-case-in-point
#15
G Ian Taylor, David S Sparks, Adam C Gascoigne, Russell J Corlett, Mark W Ashton
BACKGROUND: As we enter an age with new approaches to tissue reconstruction, the emphasis on the adage "like for like" has become even more relevant. This study illustrates the potential for several tailored vascularized composite allotransplantation reconstructive techniques and, in particular, for the management of Volkmann contracture. METHODS: Twenty fresh cadaver dissections and 30 archival lead oxide radiographic studies were examined to (1) identify potential upper limb vascularized composite allotransplantation donor sites (i...
June 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28538530/clinical-assessment-and-diagnostics-of-patients-with-hand-disorders-a-case-study-approach
#16
Mabel Qi He Leow, Rebecca Qian Ru Lim, Shian Chao Tay
Clinical assessment of the hand is important for diagnosing underlying hand disorders. Using a case study approach, the clinical assessment for three disorders of the hands is presented: trigger finger (stenosing tenosynovitis), carpal tunnel syndrome, and ulnar-sided wrist injury (styloid impingement). We assess the annular one pulley and finger range of motion for patients with trigger finger. To diagnose for carpal tunnel syndrome, assessment for Tinel's sign, Phalen's sign, abductor pollicis brevis muscle bulk, two-point discrimination, and obtaining a nerve conduction study are performed...
May 2017: Orthopaedic Nursing
https://www.readbyqxmd.com/read/28538257/what-s-in-the-literature
#17
Mark Bromberg, Nicholas J Silvestri, David Lacomis
In this edition, we provide a detailed summary of an informative book, "GBS100: Celebrating a Century of Progress in Guillain-Barré Syndrome" developed by the Peripheral Nerve Society to honor the centenary of the original paper on Guillain-Barré Syndrome. We also review various studies in myasthenia gravis including: management with rituximab; the efficacy of early fast-acting treatment with corticosteroids; and various dosing strategies for tacrolimus. Finally, we review new studies including: the potential pathogenesis, risk factors, and functional decline of patients with inclusion body myositis; MxA immunoreactivity in dermatomyositis; diagnostic approaches for evaluating patients with myalgia, fatigue, and exercise intolerance; MRI patterns in genetic muscle disease; and MRI as an outcome measure in facioscapulohumeral muscular dystrophy...
June 2017: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/28538253/immune-myopathy-with-perimysial-pathology-associated-with-interstitial-lung-disease-and-anti-ej-antibodies
#18
Patrick M Kwon, Lan Zhou, Rajeev Motiwala, Leslie D Kerr, Susan C Shin
OBJECTIVES: We report a case of immune myopathy with perimysial pathology associated with anti-glycyl-transfer RNA synthetase (anti-EJ) antibody and an excellent treatment response. METHODS: Chart review. RESULTS: A 36-year-old woman presented with 3 months of fatigue, weight loss, progressive weakness in a scapuloperoneal distribution, and dysphagia. Nerve conduction studies, electromyography, and ultrasound suggested an irritable myopathy...
June 2017: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/28537696/electron-microscopic-changes-of-detrusor-in-benign-enlargement-of-prostate-and-its-clinical-correlation
#19
Sher Singh Yadav, Rohit Bhattar, Lokesh Sharma, Gautam Banga, Trilok Chandra Sadasukhi
AIMS: To study the ultra structural changes in bladder musculature in cases of BPE and their clinical relevance. MATERIAL AND METHODS: In this descriptive longitudinal, controlled, observational study patients were enrolled into three groups, group 1, group 2A and group 2B. Control group (group-1) consisted of age matched normal male patients, who underwent surveillance or diagnostic cystoscopy for microscopic hematuria or irritative symptoms. Case group (group-2) comprised of patients with BPE, undergoing TURP...
May 23, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28537429/core-outcome-measures-for-clinical-research-in-acute-respiratory-failure-survivors-an-international-modified-delphi-consensus-study
#20
Dale M Needham, Kristin A Sepulveda, Victor D Dinglas, Caroline M Chessare, Lisa Aronson Friedman, Clifton O Bingham Iii, Alison E Turnbull
RATIONALE: Research evaluating acute respiratory failure (ARF) survivors' outcomes after hospital discharge has substantial heterogeneity in measurement instruments used, creating barriers to synthesizing study data. OBJECTIVES: To identify a minimum set of core outcome measures that are essential to include in all clinical research studies evaluating ARF survivors after discharge. METHODS: A three-round modified Delphi consensus process with 77 participants (47% female, 55% outside USA), including clinical researchers from >16 countries across 6 continents, patients/caregivers, clinicians, and research funders...
May 24, 2017: American Journal of Respiratory and Critical Care Medicine
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