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https://www.readbyqxmd.com/read/29767565/medical-management-of-deep-ulcerative-keratitis-in-cats-13-cases
#1
Michelle G Martin de Bustamante, Kathryn L Good, Brian C Leonard, Steven R Hollingsworth, Sydney G Edwards, Kelly E Knickelbein, Ann E Cooper, Sara M Thomasy, David J Maggs
Case series summary Described are 13 cats diagnosed with deep ulcerative keratitis and successfully managed medically without grafting procedures. Typical treatment involved frequent topical application of serum and antibiotics (usually a fluoroquinolone and a cephalosporin). Seven cats also received systemic antibiotics. Analgesia was achieved using various combinations of topical atropine and systemic buprenorphine, robenacoxib or corticosteroids. Six cats were hospitalized for a median (range) period of 2...
May 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29763278/implantable-buprenorphine-probuphine-for-maintenance-treatment-of-opioid-dependence
#2
Nancy Hope Goodbar, Katherine E Hanlon
No abstract text is available yet for this article.
May 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29762767/concerns-and-help-seeking-among-patients-using-opioids-for-management-of-chronic-noncancer-pain
#3
Briony Larance, Gabrielle Campbell, Teleri Moore, Suzanne Nielsen, Raimondo Bruno, Nicholas Lintzeris, Milton Cohen, Wayne Hall, Richard Mattick, Courtney O'Donnell, Louisa Degenhardt
Background: The safety and efficacy of long-term opioid treatment for chronic noncancer pain (CNCP) remains controversial. This study examined whether patients who report problematic opioid use sought help and/or perceived barriers to help-seeking. Methods: Data were collected from 1,086 people prescribed opioids for CNCP via a large prospective cohort called the Pain and Opioids IN Treatment (POINT) study. Patients' characteristics and help-seeking were examined according to scores on the Prescribed Opioids Difficulties Scale (PODS)...
May 11, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29755192/efficacy-and-pharmacokinetics-of-bupivacaine-with-epinephrine-or-dexmedetomidine-after-intraperitoneal-administration-in-cats-undergoing-ovariohysterectomy
#4
Javier Benito, Beatriz Monteiro, Francis Beaudry, Paulo Steagall
The aim of this study was to determine the efficacy and pharmacokinetics of bupivacaine in combination with epinephrine or dexmedetomidine after intraperitoneal administration in cats undergoing ovariohysterectomy. Sixteen healthy adult cats (3.3 ± 0.6 kg) were included in a prospective, randomized, masked clinical trial after obtaining owners' consent. Anesthetic protocol included buprenorphine-propofol-isoflurane. Meloxicam [0.2 mg/kg body weight (BW)] was administered subcutaneously before surgery. Cats were randomly divided into 2 groups to receive 1 of 2 treatments...
April 2018: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/29747726/opioid-use-disorders-and-pregnancy
#5
REVIEW
Amanda J Johnson, Cresta W Jones
Opioid use disorder presents an increased risk of complications in pregnancy, particularly when untreated. To optimize outcomes, medication-assisted treatment using methadone or buprenorphine as a part of a comprehensive care model is recommended. Neonatal abstinence syndrome and poor fetal growth remain significant complications of this disorder despite maternal treatment.
June 2018: Obstetrics and Gynecology Clinics of North America
https://www.readbyqxmd.com/read/29735615/facilitators-and-barriers-to-naloxone-kit-use-among-opioid-dependent-patients-enrolled-in-medication-assisted-therapy-clinics-in-north-carolina
#6
Prasana Khatiwoda, Rae Jean Proeschold-Bell, Christina S Meade, Lawrence P Park, Scott Proescholdbell
BACKGROUND Naloxone-an opioid antagonist that reverses the effects of opioids-is increasingly being distributed in non-medical settings. We sought to identify the facilitators of, and barriers to, opioid users using naloxone kits in North Carolina. METHODS In 2015, we administered a 15-item survey to a convenience sample of 100 treatment seekers at 4 methadone/buprenorphine Medication Assisted Therapy (MAT) clinics in North Carolina. RESULTS Seventy-four percent of participants reported having ever gotten a naloxone kit; this percentage was higher for females (81%) than males (63%) ( P = ...
May 2018: North Carolina Medical Journal
https://www.readbyqxmd.com/read/29734918/buprenorphine-use-and-spending-for-opioid-use-disorder-treatment-trends-from-2003-to-2015
#7
Andrew W Roberts, Brendan Saloner, Stacie B Dusetzina
OBJECTIVE: This study examined buprenorphine prescription uptake and expenditure trends among privately insured adults from 2003 to 2015 to inform efforts to expand opioid use disorder treatment. METHODS: A study with a repeated cross-sectional design using MarketScan prescription claims data was conducted to describe trends in total and new buprenorphine use and median total, plan, and out-of-pocket expenditures for a 30-day buprenorphine prescription among privately insured adults from 2003 to 2015...
May 8, 2018: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29731664/perioperative-analgesia-with-a-buprenorphine-transdermal-patch-for-hallux-valgus-surgery-a-prospective-randomized-controlled-study
#8
Can Xu, Mingqing Li, Chenggong Wang, Hui Li, Hua Liu
Purpose: Hallux valgus surgery often results in significant postoperative pain. Adequate control of pain is essential for patient satisfaction and improves the outcome of the procedure. This study aimed to investigate the perioperative analgesic effect of a buprenorphine transdermal patch in patients who underwent hallux valgus surgery. Patients and methods: A total of 90 patients were randomly divided into the following three groups based on the perioperative analgesic method: flurbiprofen axetil intravenous injection (Group F), oral celecoxib (Group C), and buprenorphine transdermal delivery system (BTDS) (Group BTDS)...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29730987/stigma-associated-with-medication-treatment-for-young-adults-with-opioid-use-disorder-a-case-series
#9
Scott E Hadland, Tae Woo Park, Sarah M Bagley
BACKGROUND: Opioid-related overdose deaths have risen sharply among young adults. Despite this increase, access to evidence-based medication for opioid agonist treatment (OAT) for youth remains low. Among older adults, barriers to OAT include the paucity of buprenorphine-waivered prescribers and low rates of prescribing among waivered physicians. We have increasingly found in our clinical practice significant stigma related to using OAT to treat addiction for young adults. In this series, we describe three cases of young adults who faced significant stigma related to their treatment...
May 7, 2018: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/29727755/are-patients-pejorative-representations-of-buprenorphine-associated-with-their-level-of-addiction-and-of-misuse
#10
Paul Vanderkam, Stéphanie Gagey, Pierre Ingrand, Marie-Christine Perault-Pochat, Yann Brabant, Clara Blanchard, Benoit Tudrej, Nassir Messaadi, Philippe Binder
BACKGROUND: In France, buprenorphine is at once the most widely prescribed and the most commonly misused opioid maintenance treatment (OMT). Unlike other medicines, it is seldom prescribed as a generic drug. Several studies have underlined the influence of the patient's representations when choosing brand-name rather than generic forms. We aim to prove a link between these pejorative representations and misuse, a higher degree of addiction and a preference for brand-name products. METHODS: An observational study carried out at 11 sites in France using self-assessment questionnaires filled out in dispensing pharmacies by patients having come to them for buprenorphine delivery...
April 27, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29726847/opioid-induced-hyperalgesia-in-the-nonsurgical-setting-a-systematic-review
#11
David Z Yang, Billy Sin, Joshua Beckhusen, Dawei Xia, Rebecca Khaimova, Ilia Iliev
BACKGROUND: Opioid-induced hyperalgesia (OIH) is a phenomenon that causes an increased pain sensitization and perception of pain to noxious stimuli secondary to opioid exposure. While this clinical effect has been described in the surgical setting, it is unclear if OIH occurs in the nonsurgical setting. STUDY QUESTION: To review the available literature which evaluated OIH in nonsurgical settings. DATA SOURCES: A comprehensive literature search was performed using PubMed (January 1946-July 2017) using a variety of keywords for OIH...
January 31, 2018: American Journal of Therapeutics
https://www.readbyqxmd.com/read/29725986/efficacy-and-safety-of-analgesic-treatment-for-depression-in-people-with-advanced-dementia-randomised-multicentre-double-blind-placebo-controlled-trial-dep-pain-dem
#12
Ane Erdal, Elisabeth Flo, Dag Aarsland, Clive Ballard, Dagrun D Slettebo, Bettina S Husebo
BACKGROUND: Chronic pain and depression often co-occur, and pain may exacerbate depression in people with dementia. OBJECTIVE: The objective of this study was to assess the efficacy and safety of analgesic treatment for depression in nursing home patients with advanced dementia and clinically significant depressive symptoms. METHODS: We conducted a multicentre, parallel-group, double-blind, placebo-controlled trial in 47 nursing homes, including 162 nursing home patients aged ≥ 60 years with dementia (Mini-Mental State Examination ≤ 20) and depression (Cornell Scale for Depression in Dementia ≥ 8)...
May 3, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29724879/unit-dose-packaging-and-unintentional-buprenorphine-naloxone-exposures
#13
George Sam Wang, S Geoffrey Severtson, Gabrielle E Bau, Richard C Dart, Jody L Green
BACKGROUND AND OBJECTIVES: Buprenorphine accounts for the most opioid-related pediatric hospital admissions when compared with other opioid analgesics. Since 2010, several manufacturers began distributing their buprenorphine products with unit-dose packaging (UDP). Our main objective in this study is to evaluate the impact of UDP on unintentional pediatric buprenorphine-naloxone poison center exposures. METHODS: This is an observational surveillance study in which the Researched Abuse, Diversion, and Addiction-Related Surveillance System Poison Center Program is used...
May 3, 2018: Pediatrics
https://www.readbyqxmd.com/read/29723483/breastfeeding-intention-compared-with-breastfeeding-postpartum-among-women-receiving-medication-assisted-treatment
#14
Nicole Yonke, Rebekah Maston, Sherry Weitzen, Lawrence Leeman
BACKGROUND: Women taking methadone or buprenorphine are encouraged to breastfeed if stable without polysubstance use. Research Aim: We aimed to determine the difference between stated intention to breastfeed prenatally in women taking methadone or buprenorphine compared with breastfeeding at discharge and 2 months postpartum. Secondary outcomes were determining whether breastfeeding was more common in women taking buprenorphine, in women without hepatitis C infection, and in women without a history of heroin use, and whether breastfeeding reduced the need for pharmacological treatment of neonatal opioid withdrawal syndrome...
April 1, 2018: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/29718715/treatment-outcomes-among-a-cohort-of-african-american-buprenorphine-patients-follow-up-at-12-months
#15
Laura B Monico, Jan Gryczynski, Robert P Schwartz, Jerome H Jaffe, Kevin E O'Grady, Shannon Gwin Mitchell
BACKGROUND: Although buprenorphine/naloxone (bup/nal) is well-established as a safe and effective treatment for opioid use disorders (OUDs), there are few studies reporting 12-month outcomes of patients receiving bup/nal in formerly drug-free outpatient programs. OBJECTIVES: To examine 12-month outcomes by bup/nal treatment enrollment status among a cohort of African American patients enrolled in a clinical trial. METHODS: This analysis builds upon a randomized trial of 300 opioid-dependent African American bup/nal patients in two outpatient programs in Baltimore, MD...
May 2, 2018: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/29716837/comparison-of-the-postoperative-analgesic-effects-of-cimicoxib-buprenorphine-and-their-combination-in-healthy-dogs-undergoing-ovariohysterectomy
#16
Rocío Bustamante, María A Daza, Susana Canfrán, Paloma García, María Suárez, Ignacio Trobo, Ignacio A Gómez de Segura
OBJECTIVE: To determine the noninferior postoperative analgesic efficacy of cimicoxib compared to buprenorphine following elective ovariohysterectomy in healthy bitches. STUDY DESIGN: Prospective, randomized, blinded, controlled clinical trial. ANIMALS: A total of 63 healthy dogs. METHODS: To provide perioperative analgesia, cimicoxib 2 mg kg-1 (orally), buprenorphine 0.02 mg kg-1 (two doses, intramuscularly), or both drugs combined, were administered...
February 5, 2018: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29710079/neurobiology-of-opioid-use-disorder-and-comorbid-traumatic-brain-injury
#17
Thomas R Kosten, David P Graham, David A Nielsen
Importance: Treating patients with opioid use disorder (OUD) and traumatic brain injury illustrates 6 neurobiological principles about the actions of 2 contrasting opioid analgesics, morphine and fentanyl, as well as pharmacotherapies for OUD, methadone, naltrexone, and buprenorphine. Observations: This literature review focused on a patient with traumatic brain injury who developed OUD from chronic morphine analgesia. His treatment is described in a neurobiological framework of 6 opioid action principles...
April 25, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29706172/effects-of-medication-assisted-treatment-mat-for-opioid-use-disorder-on-functional-outcomes-a-systematic-review
#18
Margaret A Maglione, Laura Raaen, Christine Chen, Gulrez Azhar, Nima Shahidinia, Mimi Shen, Ervant Maksabedian, Roberta M Shanman, Sydne Newberry, Susanne Hempel
This systematic review synthesizes evidence on the effects of Medication-Assisted Treatment (MAT) for opioid use disorder (OUD) on functional outcomes, including cognitive (e.g., memory), physical (e.g., fatigue), occupational (e.g., return to work), social/behavioral (e.g., criminal activity), and neurological (e.g., balance) function. Five databases were searched from inception to July 2017 to identify English-language controlled trials, case control studies, and cohort comparisons of one or more groups; cross-sectional studies were excluded...
June 2018: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29702336/a-cluster-analytic-profiling-of-heroin-dependent-patients-based-on-level-clinical-adequacy-and-patient-desired-adjustment-of-buprenorphine-dosage-during-buprenorphine-naloxone-maintenance-treatment-in-sixteen-spanish-centers
#19
Saul Alcaraz, Francisco González-Saiz, Joan Trujols, Esperanza Vergara-Moragues, Núria Siñol, José Pérez de Los Cobos
BACKGROUND: Buprenorphine dosage is a crucial factor influencing outcomes of buprenorphine treatment for heroin use disorders. Therefore, the aim of the present study is to identify naturally occurring profiles of heroin-dependent patients regarding individualized management of buprenorphine dosage in clinical practice of buprenorphine-naloxone maintenance treatment. METHODS: 316 patients receiving buprenorphine-naloxone maintenance treatment were surveyed at 16 Spanish centers during the stabilization phase of this treatment...
June 1, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29698067/evaluation-of-the-thermal-antinociceptive-effects-of-a-sustained-release-buprenorphine-formulation-after-intramuscular-administration-to-american-kestrels-falco-sparverius
#20
David Sanchez-Migallon Guzman, Susanne M Ceulemans, Hugues Beaufrère, Glenn H Olsen, Joanne R Paul-Murphy
Previous studies have validated the clinical use of opioids with μ-receptor affinities for pain management in raptors. Buprenorphine has a longer duration of action and minimal adverse effects when compared with other opioids in American kestrels ( Falco sparverius). To evaluate the thermal antinociceptive effects, sedative effects, and duration of action of sustained-release buprenorphine given intramusculary in American kestrels, 12 adult kestrels (8 females and 4 males) were used in a randomized masked complete-crossover experimental design...
March 2018: Journal of Avian Medicine and Surgery
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