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https://www.readbyqxmd.com/read/28329017/navigating-in-foldonia-using-accelerated-molecular-dynamics-to-explore-stability-unfolding-and-self-healing-of-the-%C3%AE-solenoid-structure-formed-by-a-silk-like-polypeptide
#1
Binwu Zhao, Martien A Cohen Stuart, Carol K Hall
The β roll molecules with sequence (GAGAGAGQ)10 stack via hydrogen bonding to form fibrils which have been themselves been used to make viral capsids of DNA strands, supramolecular nanotapes and pH-responsive gels. Accelerated molecular dynamics (aMD) simulations are used to investigate the unfolding of a stack of two β roll molecules, (GAGAGAGQ)10, to shed light on the folding mechanism by which silk-inspired polypeptides form fibrils and to identify the dominant forces that keep the silk-inspired polypeptide in a β roll configuration...
March 22, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28323508/nefopam-hydrochloride-loaded-microspheres-for-post-operative-pain-management-synthesis-physicochemical-characterization-and-in-vivo-evaluation
#2
Neelam Sharma, Sandeep Arora, Jitender Madan
Once-daily oral dosage of nefopam hydrochloride loaded sustained release microspheres (NPH-MS) was investigated as novel therapeutic strategy for post-operative pain management. Microspheres were synthesized using poly-3-hydroxybutyrate and poly-(ɛ-caprolactone) by double emulsion solvent evaporation technique. NPH-MS were characterized through FTIR, PXRD and SEM. In-vitro drug release study revealed sustained behavior till 24 h. Haemolysis was <5% which signified haemocompatibility of formulation. ED50 in rat tail-flick anti-nociceptive test was found ∼18...
March 21, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28323088/localization-of-the-corticospinal-tract-within-the-porcine-spinal-cord-implications-for-experimental-modeling-of-traumatic-spinal-cord-injury
#3
Anna Victoria Leonard, Joshua York Menendez, Betty Maki Pat, Mark N Hadley, Candace Lorraine Floyd
Spinal cord injury (SCI) researchers have predominately utilized rodents for SCI modeling and experimentation. Unfortunately, a large number of novel therapies developed in rodent models have failed to demonstrate efficacy in human clinical trials which suggests that improved animal models are an important translational tool. Recently, porcine models of SCI have been identified as a valuable intermediary model for preclinical evaluation of promising therapies to aid clinical translation. However, the localization of the major spinal tracts in pigs has not yet been described...
March 16, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28317554/chimpanzee-and-human-midfoot-motion-during-bipedal-walking-and-the-evolution-of-the-longitudinal-arch-of-the-foot
#4
Nicholas B Holowka, Matthew C O'Neill, Nathan E Thompson, Brigitte Demes
The longitudinal arch of the human foot is commonly thought to reduce midfoot joint motion to convert the foot into a rigid lever during push off in bipedal walking. In contrast, African apes have been observed to exhibit midfoot dorsiflexion following heel lift during terrestrial locomotion, presumably due to their possession of highly mobile midfoot joints. This assumed dichotomy between human and African ape midfoot mobility has recently been questioned based on indirect assessments of in vivo midfoot motion, such as plantar pressure and cadaver studies; however, direct quantitative analyses of African ape midfoot kinematics during locomotion remain scarce...
March 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28316410/first-record-of-gnathia-sp-an-ectoparasitic-isopod-isolated-from-the-coral-reef-fish-heniochus-acuminatus-collected-from-the-gulf-of-mannar-region-southeast-coast-of-india
#5
G Jayanthi, M Anand, G Chelladurai, A K Kumaraguru
An ectoparasitic isopod, Gnathia sp. was found in the Gill chambers of Heniochus acuminatus collected from the Gulf of Mannar region, Southeast coast of India. The present study signifies the new record of Gnathia sp. an coral reef ectoparasitic isopod captured from the gill net during October 2014. Among the 36 specimens examined 5 specimens were infested with Pranzia larvae of Gnathia sp. The size of the isopods were ranged from 1.5 to 3.2 mm and the host fish length varied between 119 and 230 mm. They were specifically found attached to the gill chambers and no damage observed in the lamellar pattern...
March 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28315754/hepatitis-b-and-htlv-1-co-infection-in-the-northern-territory-australia
#6
Ian Marr, Jane Davies, Rob W Baird
OBJECTIVE: To establish the relationship of Hepatitis B and HTLV-1 serological markers in the Northern Territory, Australia. METHODS: A retrospective serological study of patients, presenting to public healthcare facilities, in the Northern Territory between 2008 and 2015, was performed to determine presence and relationships of serological markers of Hepatitis B virus (HBV), and Human T-cell Leukemic virus 1 (HTLV-1). RESULTS: There were 740 individual cases of serological positive HTLV-1 identified over 8 years in the Northern Territory...
March 15, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28298297/angiogenic-mechanisms-of-human-cd34-stem-cell-exosomes-in-the-repair-of-ischemic-hindlimb
#7
Prabhu Mathiyalagan, Yaxuan Liang, David Kim, Sol Misener, Tina Thorne, Christine Kamide, Ekaterina Klyachko, Douglas W Losordo, Roger J Hajjar, Susmita Sahoo
Rationale: Paracrine secretions appear to mediate therapeutic effects of human CD34(+) stem cells locally transplanted in patients with myocardial and critical limb ischemia as well as in animal models. Earlier, we had discovered that paracrine secretion from human CD34(+) cells contains pro-angiogenic, membrane-bound nano-vesicles called exosomes (CD34Exo). Objective: Here, we investigated the mechanisms of CD34Exo-mediated ischemic tissue repair and therapeutic angiogenesis by studying their miRNA content and uptake...
March 15, 2017: Circulation Research
https://www.readbyqxmd.com/read/28296731/clinical-outcomes-of-iga-nephropathy-patients-with-different-proportions-of-crescents
#8
Wang Zhang, Qian Zhou, Lingyao Hong, Wenfang Chen, Shicong Yang, Qiongqiong Yang, Wei Chen, Xueqing Yu
Crescents involving more than 50% of glomeruli in IgA nephropathy (IgAN) signify a rapid deterioration of renal function. However, little is known about the prognosis of IgAN patients presenting crescents in less than 50% of glomeruli. We aimed to investigate the clinicopathological characteristics and outcomes of IgAN patients with different proportions of crescents.From January 2000 to December 2011, biopsy-proven primary IgAN patients with histological crescents formation were enrolled in this retrospective cohort study...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28293857/effect-of-cilostazol-in-treating-diabetes-associated-microvascular-complications
#9
REVIEW
Nicole J Asal, Karolina A Wojciak
PURPOSE: Cilostazol (Pletal), a phosphodiesterase-3 inhibitor, was approved in the United States in 1999 to reduce symptoms of intermittent claudication. Cyclic adenosine monophosphate levels increase from inhibition of phosphodiesterase resulting in anti-platelet, anti-inflammatory, and vasodilatory effects. Diabetes mellitus is a chronic disease that causes endothelial and platelet dysfunction leading to both microvascular and macrovascular complications. This mini-review highlights the emerging evidence suggesting benefits of using cilostazol in treating microvascular complications associated with diabetes mellitus...
March 14, 2017: Endocrine
https://www.readbyqxmd.com/read/28293718/transfection-of-primary-brain-capillary-endothelial-cells-for-protein-synthesis-and-secretion-of-recombinant-erythropoietin-a-strategy-to-enable-protein-delivery-to-the-brain
#10
Annette Burkhart, Thomas Lars Andresen, Achim Aigner, Louiza Bohn Thomsen, Torben Moos
Treatment of chronic disorders affecting the central nervous system (CNS) is complicated by the inability of drugs to cross the blood-brain barrier (BBB). Non-viral gene therapy applied to brain capillary endothelial cells (BCECs) denotes a novel approach to overcome the restraints in this passage, as turning BCECs into recombinant protein factories by transfection could result in protein secretion further into the brain. The present study aims to investigate the possibility of transfecting primary rat brain endothelial cells (RBECs) for recombinant protein synthesis and secretion of the neuroprotective protein erythropoietin (EPO)...
March 14, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28293448/serum-calreticulin-as-a-novel-biomarker-of-juvenile-idiopathic-arthritis-disease-activity
#11
Nashwa Ismail Hashaad, Rasha Mohamed Fawzy, Abeer Ahmed Abo Elazem, Mohamed Ibrahim Youssef
OBJECTIVE: This study aimed to investigate the relations between calreticulin (CRT) serum level and both disease activity and severity parameters in juvenile idiopathic arthritis (JIA). MATERIAL AND METHODS: In this study, 60 children with JIA and 50 age-and-sex-matched healthy subjects were enrolled. The assessment of the disease activity was done using juvenile arthritis disease activity score 27 (JADAS-27). The assessment of disease severity was done via gray-scale ultrasonography (US) and power Doppler US (PDUS)...
March 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28292692/using-critical-flicker-frequency-in-the-evaluation-of-visual-impairment-in-preeclamptic-women
#12
Marina Maier, Andreas Brückmann, Ekkehard Schleußner, Dietmar Schlembach
OBJECTIVE: To assess critical flicker frequency (CFF) in normal uneventful pregnancy and preeclampsia. STUDY-DESIGN: Case-control observational study at the University Hospital Jena and Outpatient Institute for Prenatal Diagnosis and Preventive Medicine. 25 non-pregnant women, 75 uncomplicated pregnant women in first, second and third trimester, and 15 women with overt preeclampsia. For comparison with preeclamptic patients we matched 15 normal pregnant women (mNP) for age, parity, body mass index, current smoking and family history of cardiovascular disease (CVD)...
March 1, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28291394/cycad-palm-toxicosis-in-14-dogs-from-texas
#13
Carolyn Clarke, Derek Burney
The goal of this study is to report clinical information, diagnostic findings, and treatment modalities; assess variables that may help distinguish survivors from nonsurvivors; and review the outcome of cycad palm toxicosis in dogs. Fourteen client-owned dogs with confirmed cycad palm ingestion were identified by reviewing the medical record database at Gulf Coast Veterinary Specialists. Information on signalment, time of ingestion to presentation, clinical signs, physical examination findings, initial and peak/nadir laboratory abnormalities, radiographic and ultrasonographic findings, treatment modalities, liver histopathology, and clinical outcome was retrieved...
March 14, 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/28288664/injured-bodies-damaged-lives-experiences-and-narratives-of-kenyan-women-with-obstetric-fistula-and-female-genital-mutilation-cutting
#14
Lillian Mwanri, Glory Joy Gatwiri
BACKGROUND: It is well acknowledged that Female Genital Mutilation/Cutting (FGM/C/C) leads to medical, psychological and sociocultural sequels. Over 200 million cases of FGM/C exist globally, and in Kenya alone, a total of 12,418,000 (28%) of women have undergone FGM/C, making the practice not only a significant national, but also a global health catastrophe. FGM/C is rooted in patriarchal and traditional cultures as a communal experience signifying a transition from girlhood to womanhood...
March 14, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28288437/podiatry-impact-on-high-low-amputation-ratio-characteristics-a-16-year-retrospective-study
#15
Brian M Schmidt, James S Wrobel, Michael Munson, Gary Rothenberg, Crystal M Holmes
PURPOSE: Complications from diabetes mellitus including major lower extremity amputation may have significant impact on a patient's mortality. This study determined what impact the addition of a limb salvage and diabetic foot program involving podiatry had at an academic institution over 16years by analyzing high-low amputation ratio data. METHODS: The high-low amputation ratio in the diabetic population who underwent non-traumatic amputation of the lower extremity was retrospectively evaluated at an academic institution via cohort discovery of the electronic medical record and analysis of billing over 16years...
February 21, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28287033/marine-macromolecules-cross-linked-hydrogel-scaffolds-as-physiochemically-and-biologically-favorable-entities-for-tissue-engineering-applications
#16
Muraleedhara Kurup G, Sumayya A S
Marine biopolymer composite materials provide a technological platform for launching biomedical applications. Biomaterials demand good biocompatibility without the possibility of inflammation or foreign body reactions. In this study, we prepared two biocomposite hydrogels namely; HAC (hydroxyapatite, alginate & chitosan) and HACF (hydroxyapatite, alginate, chitosan & fucoidan) followed by calcium chloride cross linking. The prepared scaffolds were characterized by Fourier Transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM)...
March 11, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28281180/comparative-analysis-of-oxidative-stress-during-aging-of-kluyveromyces-marxianus-in-synthetic-and-whey-media
#17
Priyanka Saini, Arun Beniwal, Shilpa Vij
During the aging of yeast culture, Kluyveromyces marxianus undergoes a number of changes in physiology and these changes play a significant role during fermentation. Aged stationary phase cells were found to contain more reactive oxygen species. Additionally, the level of oxidant is counteracted by the antioxidant defense system of the cells. Comparison of 3-day-old culture of K. marxianus with 45-day stationary phase culture represents an increased level of ROS inside the cells. Moreover, a decrease in glutathione content was observed over the set of the incubation period...
March 9, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28280451/effects-of-terminal-sterilization-on-peg-based-bioresorbable-polymers-used-in-biomedical-applications
#18
Divya Bhatnagar, Koustubh Dube, Vinod B Damodaran, Ganesan Subramanian, Kenneth Aston, Frederick Halperin, Meiyu Mao, Kurt Pricer, N Sanjeeva Murthy, Joachim Kohn
The effects of ethylene oxide (EO), vaporized hydrogen peroxide (VHP), gamma (γ) radiation, and electron-beam (E-beam) on the physiochemical and morphological properties of medical device polymers are investigated. Polymers with ether, carbonate, carboxylic acid, amide and ester functionalities are selected from a family of poly(ethylene glycol) (PEG) containing tyrosine-derived polycarbonates (TyrPCs) to include slow, medium, fast, and ultrafast degrading polymers. Poly(lactic acid) (PLA) is used for comparison...
October 2016: Macromolecular Materials and Engineering
https://www.readbyqxmd.com/read/28279427/finite-element-analysis-of-the-three-different-posterior-malleolus-fixation-strategies-in-relation-to-different-fracture-sizes
#19
Adeel Anwar, Decheng Lv, Zhi Zhao, Zhen Zhang, Ming Lu, Muhammad Umar Nazir, Wasim Qasim
PURPOSE: Appropriate fixation method for the posterior malleolar fractures (PMF) according to the fracture size is still not clear. Aim of this study was to evaluate the outcomes of the different fixation methods used for fixation of PMF by finite element analysis (FEA) and to compare the effect of fixation constructs on the size of the fracture computationally. MATERIALS AND METHODS: Three dimensional model of the tibia was reconstructed from computed tomography (CT) images...
February 20, 2017: Injury
https://www.readbyqxmd.com/read/28277848/kozeny-carman-permeability-relationship-with-disintegration-process-predicted-from-early-dissolution-profiles-of-immediate-release-tablets
#20
Parveen Kumari, Pooja Rathi, Virender Kumar, Jatin Lal, Harmeet Kaur, Jasbir Singh
This study was oriented towards the disintegration profiling of the diclofenac sodium (DS) immediate-release (IR) tablets and development of its relationship with medium permeability kperm based on Kozeny-Carman equation. Batches (L1-L9) of DS IR tablets with different porosities and specific surface area were prepared at different compression forces and evaluated for porosity, in vitro dissolution and particle-size analysis of the disintegrated mass. The kperm was calculated from porosities and specific surface area, and disintegration profiles were predicted from the dissolution profiles of IR tablets by stripping/residual method...
March 1, 2017: Drug Development and Industrial Pharmacy
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