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https://www.readbyqxmd.com/read/29784867/patient-beliefs-and-attitudes-to-taking-statins-systematic-review-of-qualitative-studies
#1
Angela Ju, Camilla S Hanson, Emily Banks, Rosemary Korda, Jonathan C Craig, Tim Usherwood, Peter MacDonald, Allison Tong
BACKGROUND: Statins are effective in preventing cardiovascular disease (CVD) events and are recommended for at-risk individuals but estimated adherence rates are low. AIM: To describe patients' perspectives, experiences, and attitudes towards taking statins. DESIGN AND SETTING: Systematic review of qualitative studies reporting perspectives of patients on statins. METHOD: PsycINFO, CINAHL, Embase, MEDLINE, and PhD dissertations from inception to 6 October 2016 were searched for qualitative studies on adult patients' perspectives on statins...
May 21, 2018: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29781445/enhanced-room-temperature-gas-sensing-of-aligned-mn3o4-nanorods-assemblies-functionalized-by-aluminum-anodic-membranes
#2
Neetha Rachel John, Paulose Thomas, Divya K V, Abraham K E
The study signifies a conductometric chemical sensor design using aligned Mn3O4 nanorods. Nanostructuring is an emerging field of prominence due to its capacity to introduce unprecedented properties in materials with potential applications. Hydrothermally prepared in situ Mn3O4 sample appears in urchin rod like morphology which changes to spherical shape on annealing. An aluminum anodic membrane/template (AAO) is used for the growth of the nanorods and also as a medium to support the sensor. Aligned Mn3O4nanorods are formed in the pores of AAO by vacuum infiltration approach which is later on annealed...
May 21, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29780746/a-novel-herbal-formulation-versus-chlorhexidine-mouthwash-in-efficacy-against-oral-microflora
#3
K S Vinod, K S Sunil, Priyanka Sethi, Ram Chand Bandla, Subhasini Singh, Deepak Patel
Aims and Objectives: The aim of the study was to compare and to analyze the antimicrobial efficacy of 0.12% chlorhexidine and new formulated herbal mouthwash after using for 14 days. The objective was to signify whether the noval herbal combination could be a better alternative mouthwash to Chlorhexidine (CHX). Materials and Methods: This is a double-blinded, random controlled research study conducted in the Department of Oral Pathology and Microbiology. A total of 200 dental students were selected randomly, comprising of two groups, 100 in each, aged between 18 and 22 years with gingival index of score II...
March 2018: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29779023/parathyroid-hormone-fibroblast-growth-factor-23-and-parameters-of-phosphate-reabsorption
#4
Kenneth R Phelps, Darius L Mason
BACKGROUND: The serum phosphorus concentration ([P]s) is the sum of EP/Ccr and TRP/Ccr, where Ccr is creatinine clearance and EP and TRP are rates of excretion and reabsorption of phosphate. In chronic kidney disease (CKD), parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) mediate reduction of TRP/Ccr, and [PTH] and [FGF23] are linear functions of EP/Ccr. If controls and patients with CKD are considered together, TRP/Ccr is a hyperbolic function of EP/Ccr. Given these observations, we hypothesized that hyperbolas would describe relationships of phosphate reabsorption to [PTH] and [FGF23]...
May 18, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29778874/simultaneous-determination-of-dihydrotestosterone-and-its-metabolites-in-mouse-sera-by-lc-ms-ms-with-chemical-derivatization
#5
Shashank Gorityala, Shuming Yang, Monica M Montano, Yan Xu
Androgens play a vital role in prostate cancer development, and their elimination and blockade are essential in the disease management. DHT is the key ligand for androgen receptor (AR) in the prostate. It is locally synthesized from testosterone. In the prostate, DHT is predominantly metabolized to α-diol and β-diol. Recent studies indicate that impaired DHT catabolism is associated with prostate cancer, signifying the necessity of a sensitive quantitative method for the determination of DHT and its metabolites...
May 16, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29768590/-construction-and-deconstruction-of-masculine-identities-among-metalworkers-with-rsi-wrmd
#6
Jorge Henrique Santos Saldanha, Mônica Angelim Gomes de Lima, Robson da Fonseca Neves, Jorge Alberto Bernstein Iriart
This study aimed to reveal how metalworkers experience prolonged incapacity for work due to repetitive strain injury/work-related musculoskeletal disorder (RSI/WRMD) and the impact of chronic illness on the construction/deconstruction of masculinity. A qualitative study was performed, based on narrative interviews with male metalworkers in an automotive factory in the State of Bahia, Brazil. The results showed how the conflict in the experience of illness, the maintenance of male identity, and expectations of meeting the rules dictated by hegemonic masculinity are experienced and signified in daily life...
May 10, 2018: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29765957/genetic-insights-into-frailty-association-of-9p21-23-locus-with-frailty
#7
Sanish Sathyan, Nir Barzilai, Gil Atzmon, Sofiya Milman, Emmeline Ayers, Joe Verghese
Frailty is a complex aging phenotype associated with increased vulnerability to disability and death. Understanding the biological antecedents of frailty may provide clues to healthy aging. The genome-wide association study hotspot, 9p21-23 region, is a risk locus for a number of age-related complex disorders associated with frailty. Hence, we conducted an association study to examine whether variations in 9p21-23 locus plays a role in the pathogenesis of frailty in 637 community-dwelling Ashkenazi Jewish adults aged 65 and older enrolled in the LonGenity study...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29763925/the-influence-of-hyperlipidemia-on-endothelial-function-of-fpn1-tek-cre-mice-and-the-intervention-effect-of-tetramethylpyrazine
#8
Ming-Yue Sun, Miao Zhang, Shui-Ling Chen, Shu-Ping Zhang, Chun-Yu Guo, Jing-Shang Wang, Xin Liu, Yang Miao, Hui-Jun Yin
BACKGROUND/AIMS: Systemic iron homeostasis is strictly governed in mammals; however, disordered iron metabolism (such as excess iron burden) is recognized as a risk factor for various types of diseases including AS (Atherosclerosis). The hepcidin-ferroportin axis plays the key role in regulation of iron homeostasis and modulation of this signaling could be a potential therapeutic strategy in the treatment of these diseases. TMP (Tetramethylpyrazine) has been reported to have therapeutical effect on AS...
May 9, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29759332/sunset-stereotactic-radiation-for-ultracentral-non-small-cell-lung-cancer-a-safety-and-efficacy-trial
#9
Meredith Giuliani, Ashwathy S Mathew, Houda Bahig, Scott V Bratman, Edith Filion, Daniel Glick, Alexander V Louie, Srinivas Raman, Anand Swaminath, Andrew Warner, Vivian Yau, David Palma
BACKGROUND: Lung stereotactic body radiotherapy (SBRT) is considered a standard curative treatment for medically inoperable early stage non-small-cell lung cancer (NSCLC). Patients with ultracentral tumors (signifying tumors whose planning target volume touches or overlaps the central bronchial tree, esophagus, or pulmonary artery) may be at higher risk of serious toxicities such as bronchial stricture and collapse, esophageal strictures, tracheal-esophageal fistula, and hemorrhage. The primary objective of the study is to determine the maximum tolerated dose of radiotherapy for ultracentral NSCLC...
April 18, 2018: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29755989/assessing-biosecurity-risks-for-the-introduction-and-spread-of-diseases-among-commercial-sheep-properties-in-new-south-wales-australia-using-foot-and-mouth-disease-as-a-case-study
#10
Jake Fountain, Robert Woodgate, Luzia Rast, Marta Hernández-Jover
Sheep production systems are a major industry in Australia, with a gross value of roughly $4.66 billion; 87.3% of which is attributable to export markets. Exotic diseases such as foot-and-mouth disease (FMD) are a potential threat to the viability of Australia's export market. Previous outbreaks of FMD in developed countries, and challenges in the management of onshore biosecurity, signify the importance of on-farm biosecurity in controlling disease transmission. This study aims to investigate the risk of disease introduction and spread among New South Wales (NSW) sheep properties using FMD as a case study and draw recommendation for the industry...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29755225/classification-of-electrophotonic-images-of-yogic-practice-of-mudra-through-neural-networks
#11
Kotikalapudi Shiva Kumar, T M Srinivasan, Judu Ilavarasu, Biplob Mondal, H R Nagendra
Background: Mudras signify a gesture with hands, eyes, and the body. Different configurations of the joining of fingertips are also termed mudra and are used by yoga practitioners for energy manipulation and for therapeutic applications. Electrophotonic imaging (EPI) captures the coronal discharge around the fingers as a result of electron capture from the ten fingers. The coronal discharge around each fingertip is studied to understand the effect of mudra on EPI parameters. Methods: The participants were from Swami Vivekananda Yoga Anusandhana Samsthana and Sushrutha Ayurvedic Medical College, in Bengaluru, India...
May 2018: International Journal of Yoga
https://www.readbyqxmd.com/read/29745144/-evaluation-and-selection-of-species-diversity-index-under-grazing-disturbance-in-alpine-mea-dow
#12
Yu Jie Niu, Si Wei Yang, Gui Zhen Wang, Li Liu, Li Min Hua
The research selected the plots of six grazing intensities in an alpine meadow in north-eastern Tibet Plateau in four years (2012-2015) and studied the relation between ten species diversity indexes, including two measured indexes (Richness and Abundance) in field and two indexes of each dominance, evenness, richness, integrated indexes, and grazing intensity as well as grazing time aiming at scientific selection of biodiversity index under grazing disturbance. The results indicated that the abundance was a better index than importance value to calculate biodiversity level because it was more sensitive to grazing disturbance...
June 18, 2017: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29744280/-paenibacillus-polymyxa-nd25-candidate-genome-for-lignocellulosic-biomass-utilization
#13
Varsha Bohra, Nishant A Dafale, Hemant J Purohit
Genome sequence of Paenibacillus polymyxa ND25 isolated from cow rumen is reported for being a potential candidate in hydrolysis of lignocellulosic plant biomass. Draft genome sequence generated 5.73 Mb data containing 4922 putative protein coding genes, of which 140 are annotated for glycoside hydrolases. P. polymyxa ND25 strain comprises diverse lignocellulolytic components, especially 12 cellulase along with 23 hemicellulases and 11 esterases, signifying its potential for lignocellulose hydrolysis. Subsequent enzyme assay exhibited the potential of strain to produce 0...
May 2018: 3 Biotech
https://www.readbyqxmd.com/read/29743852/n1-benzenesulfonyl-2-pyrazoline-hybrids-in-neurological-disorders-syntheses-biological-screening-and-computational-studies
#14
Avinash C Tripathi, Savita Upadhyay, Sarvesh Paliwal, Shailendra K Saraf
A novel series of 1,3,5-trisubstituted-2-pyrazolines (5a-5t ) was prepared via Claisen Schmidt condensation, followed by heterocyclization with hydrazine hydrate, substitution of N1 hydrogen of 2-pyrazoline nucleus with 4-chlorobenzenesulfonylchloride, applying conventional and green chemistry approaches. Among the two, microwave assisted organic synthesis (MAOS) emerged as a better synthetic tool in terms of faster reaction rate and high yield. Various physicochemical and spectral studies were conducted to characterize the synthesized derivatives including- IR, Mass, 1 H-NMR, 13 C-NMR and elemental analysis...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/29741582/probe-analysis-and-visualization-of-protein-block-level-evolution
#15
Arnaud Kress, Odile Lecompte, Olivier Poch, Julie D Thompson
Summary: Comparative studies of protein sequences are widely used in evolutionary and comparative genomics studies, but there is a lack of efficient tools to identify conserved regions ab initio within a protein multiple alignment. PROBE provides a fully automatic analysis of protein family conservation, to identify conserved regions, or 'blocks', that may correspond to structural / functional domains or motifs. Conserved blocks are identified at two different levels: (i) family level blocks indicate sites that are probably of central importance to the protein's structure or function, and (ii) sub-family level blocks highlight regions that may signify functional specialization, such as binding partners, etc...
May 7, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29737478/long-term-improvement-of-the-bio-psycho-social-state-of-cancer-patients-after-3-weeks-of-inpatient-oncological-rehabilitation-a-long-term-study-at-the-humanomed-zentrum-althofen
#16
Johann Klocker, Ursula Klocker-Kaiser, Wolfgang Pipam, Dietmar Geissler
A 3-week cancer rehabilitation program was conducted at the Humanomed Zentrum Althofen, comprising therapy of organic defects, lifestyle modification, and psycho-social support. Therapeutic efficacy was assessed in comprehensive surveys before and after the therapy, and after 6 and 12 months. The study covers a 5-year period with data from 3233 patients. Parameters of subjective health assessed according to the European Quality of Life - 5 Dimensions (EuroQol EQ-5D) standard and signifying quality of life showed significant improvement both immediately after the therapy, and after 6 and 12 months...
May 8, 2018: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29737383/neither-knowledge-deficit-nor-nimby-understanding-opposition-to-hydraulic-fracturing-as-a-nuanced-coalition-in-westmoreland-county-pennsylvania-usa
#17
Danielle M McLaughlin, Bethany B Cutts
The expansion of unconventional sources of natural gas across the world has generated public controversy surrounding fracking drilling methods. Public debates continue to reverberate through policy domains despite very inconclusive biophysical evidence of net harm. As a consequence, there is a need to test the hypothesis that resistance to fracking is due to the way it redistributes economic and environmental risks. As in many other communities, opposition to fracking is common in central Westmoreland County, Pennsylvania, (USA) but the rationale underpinning opposition is poorly understood...
May 8, 2018: Environmental Management
https://www.readbyqxmd.com/read/29736385/psychological-interventions-influence-patients-attitudes-and-beliefs-about-their-chronic-pain
#18
Audrey Vanhaudenhuyse, Aline Gillet, Nicole Malaise, Irène Salamun, Stéphanie Grosdent, Didier Maquet, Anne-Sophie Nyssen, Marie-Elisabeth Faymonville
Background: Patients' changing attitudes and beliefs about pain are considered as improvements in the treatment of chronic pain. Multidisciplinary approaches to pain allow modifications of coping strategies of patients, from passive to active. Methods: We investigate how two therapeutic treatments impact patients' attitudes and beliefs regarding pain, as measured with the Survey of Pain Attitudes (SOPA). We allocated 415 patients with chronic pain either to psychoeducation combined with physiotherapy, self-hypnosis combined with self-care learning, or to control groups...
April 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29735835/methicillin-resistant-staphylococcus-aureus-intracranial-abscess-an-analytical-series-and-review-on-molecular-surgical-and-medical-aspects
#19
Veena Kumari Haradara Bahubali, Priya Vijayan, Vasundhra Bhandari, Nagarathna Siddaiah, Dwarakanath Srinivas
Purpose: Intracranial abscess caused by methicillin-resistant Staphylococcus aureus (MRSA) is rare and unexplored. The aim of the present study is to examine the prevalence, clinical and molecular characteristics, treatment options and outcome of MRSA intracranial abscess over a period of 6 years. Patientsand Methods: A total of 21 patients were included in this retrospective study. The demographic and clinical details of all the patients were collected. Molecular typing including staphylococcal cassette chromosome mec typing, spa typing and polymerase chain reaction of Panton-Valentine leucocidin toxin (PVL) gene for the latter 6 isolates was performed...
January 2018: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29735404/impaired-expected-value-computations-coupled-with-overreliance-on-stimulus-response-learning-in-schizophrenia
#20
Dennis Hernaus, James M Gold, James A Waltz, Michael J Frank
BACKGROUND: While many have emphasized impaired reward prediction error signaling in schizophrenia, multiple studies suggest that some decision-making deficits may arise from overreliance on stimulus-response systems together with a compromised ability to represent expected value. Guided by computational frameworks, we formulated and tested two scenarios in which maladaptive representations of expected value should be most evident, thereby delineating conditions that may evoke decision-making impairments in schizophrenia...
April 3, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
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