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B S Sukovatykh, L N Belikov, M B Sukovatykh, D V Sidorov, M A Inarkhov, E B Inokhodova
AIM: to improve treatment of patients with severe atherosclerotic lesion of lower extremities arteries followed by critical ischemia by optimization of femoropopliteal bypass surgery. MATERIAL AND METHODS: Treament and survey of 60 patients with severe atherosclerotic lesion of femoropopliteotibial segment and critical lower limb ischemia were analyzed. Patients were divided into 2 groups depending on technique of femoropopliteal bypass. Conventional in situ autovenous technique was used in group 1...
2016: Khirurgiia
Leelawadee Techasatian, Sunee Panombualert, Rattapon Uppala, Charoon Jetsrisuparb
BACKGROUND: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe lifethreatening skin conditions. The most common cause of these manifestations is medications. Beside discontinued of the culprit drug, systemic corticosteroids were used as a primary treatment option among pediatric population. This study aimed to explore causative drugs (drug group/ latent period), treaments, complications, and treatment outcome (morbidity, mortality, length of hospital stay) of SJS and TEN in children...
September 20, 2016: World Journal of Pediatrics: WJP
M Ashraf, A Souka, R Adelman, S H Forster
The recent results of Protocol T have illustrated the efficacy of aflibercept in the treatment of diabetic macular edema. It also demonstrated that in patients with poor vision (<6/12), aflibercept offers anatomical and visual advantages over ranibizumab and bevacizumab in the first 12 months of treament. At 2 years, the difference between the three drugs decreased with patients with a better baseline VA (69-78) showing a statistically insignificant advantage for ranibizumab compared with aflibercept.These results were achieved using a pro-re nata (PRN) protocol, which was not previously studied in large phase 3 trials, VIVID and VISTA, that chose to compare the 2...
August 26, 2016: Eye
Burak Kazanci, Selcuk Ozdogan, Ramazan Kahveci, Emre Cemal Gokce, Kazim Yigitkanli, Aysun Gokce, Bulent Erdogan
AIM: We aimed in this study to evaluate the effect of pregabalin pretreatment on spinal cord ischemia-reperfusion(I/R) injury and compare it with methylprednisolone(MP). MATERIAL AND METHODS: Rats were randomized into four groups as follow: group 1 (sham)(n=8), group 2 (ischemia only)(n=8), group 3 (30 mg/kg pregabalin)(n=8), and group 4 (30 mg/kg methylprednisolone)(n=8). Laparotomy was performed without aortic clamp in the sham group. All animals were killed at 24 h after surgery...
April 27, 2016: Turkish Neurosurgery
Guldal Gulec Suyen, Naciye Isbil-Buyukcoskun, Nevzat Kahveci, Ece Sengun, Kasim Ozluk
In the present study, we aimed to investigate the effects of immediate and delayed treatment with intracerebroventricular (i.c.v.) gabapentin (GBP), carbamazepine (CBZ) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) on learning and memory, anxiety, and locomotor activity in rats with lithium-pilocarpine-induced status epilepticus (SE). SE was induced by intraperitoneal injections of 3mEq/kg LiCl followed by 45mg/kg pilocarpine 24h later. In the first series of experiments, rats were divided into four groups three hours after the onset of SE and received GBP (100μg/10μl, two times a day; i...
September 2016: Pharmacology, Biochemistry, and Behavior
Katharina Palmer, Julia Köpp, Gerhard Gebauer, Marcus A Horn
Wetlands represent sources or sinks of the greenhouse gas nitrous oxide (N2O). The acidic fen Schlöppnerbrunnen emits denitrification derived N2O and is also capable of N2O consumption. Global warming is predicted to cause more extreme weather events in future years, including prolonged drought periods as well as heavy rainfall events, which may result in flooding. Thus, the effects of prolonged drought and flooding events on the abundance, community composition, and activity of fen denitrifiers were investigated in manipulation experiments...
2016: Frontiers in Microbiology
Mayura Nakano, Sunao Shoji, Taro Higure, Masayoshi Kawakami, Tetsuro Tomonaga, Toshiro Terachi, Toyoaki Uchida
The objective of this study was to report our experience with weekly low-dose docetaxel (DOC) chemotherapy for patients with castration-resistant prostate cancer (CRPC). From 2007 to 2014, 39 consecutive patients received weekly low-dose DOC; the oncological effectiveness, side effects and tolerability were prospectively analyzed. The median patient age, serum prostate-specific antigen (PSA) level and Gleason score at diagnosis of prostate cancer were 71 years (range, 55-83 years), 187 ng/ml (range, 2.0-1711 ng/ml) and 8 (range, 5-10), respectively...
June 2016: Molecular and Clinical Oncology
Oscar Daher, Sylvain Nguyen, Cindi Smith, Christophe Büla, Jean-François Démonet
Dementia represents a great challenge for health care providers. Detection of cognitive impairment is critical for early diagnosis of dementia. Early diagnosis allows to initiate individualized management that focuses on maintaining patient's autonomy and supporting their caregivers. Proposed multimodal interventions include physical activity, cognitive training, mediterranean diet, and management of cardiovascular risk factors. Before the initiation of pro-cognitive therapy, medication review is essential to evaluate current treament and determine specific therapeutic objectives, based on patient's overall health and preferences...
April 20, 2016: Revue Médicale Suisse
Zhengtao Shen, Oliver McMillan, Fei Jin, Abir Al-Tabbaa
Salisbury biochar (produced from British broadleaf hardwood) with two different particle sizes (≤2mm and ≤0.15mm) was applied on a kaolin with three different lead (Pb(2+)) contamination levels (50mg/kg, 300mg/kg and 1000mg/kg) at the dosage of 1% in w/w. The short-term impact of biochar on the mobility and speciation of Pb(2+) in the kaolin was investigated using attenuation periods of 1, 7 and 28 days. The leachability and extractability of Pb(2+) in carbonic acid leaching and EDTA extraction tests as well as the speciation of Pb(2+) in soils were not significantly affected by biochar treatment during all periods...
October 5, 2016: Journal of Hazardous Materials
Matthias M Heck, Mark Thalgott, Sebastian C Schmid, William K Oh, Yixuan Gong, Li Wang, Jun Zhu, Anna-Katharina Seitz, Desiree Porst, Michael Höppner, Margitta Retz, Jürgen E Gschwend, Roman Nawroth
BACKGROUND: To determine a prognostic model derived from prostate cancer-enhanced transcripts in whole blood of castration-resistant prostate cancer (CRPC) patients and explore its applicability as a surrogate of treatment response. METHODS: Six out of twenty-three selected transcripts were identified as specific for detection of metastatic prostate cancer cells in peripheral blood using quantitative polymerase chain reaction (qPCR). Their prognostic value was explored in whole blood samples of a training cohort (n = 22 CRPC patients, New York, USA)...
September 2016: Prostate
Zeqi Zheng, Songping Yu, Wan Zhang, Yongchao Peng, Mingyu Pu, Ting Kang, Junyi Zeng, Yuefei Yu, Guorong Li
INTRODUCTION: Phytoestrogen genistein may be useful to treat pulmonary arterial hypertension (PAH). However, its mechanism is still not clear. The aim of the present study was to confirm the therapeutic effects of phytoestrogen genistein on PAH in monocrotaline-induced rat model and to explore its mechanism. MATERIALS AND METHODS: Sprague-Dawley male rats were randomly divided into 4 groups: control group (n=8), PAH group (n=8), genistein treament group with three different doses (n=8 in each dose group) and group of PI3K inhibitor LY294002...
April 18, 2016: Histology and Histopathology
Jie Zhou, Li-hua Bian, Lin Zou, Bin-qian Zhou, Wei Liu, Xiao Wang
Smoke water and distillation liquid were used to treat the seeds of Trichosathes kirilowii and to study the effects of smoke water and distillation liquid on the seed germination and seedling growth of T. kirilowii. The results showed that germination rate, germination index and germination vigor of T. kirilowii all were significantly improved with the treatment of SW and DL treatment. The activity of α-amylase were significantly increased with the treatment of SW and DL at 1:2,000. SW and DL treatment showed no significant effects on the activity of SOD...
October 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Ling Qiuyang, Wu Ting, Ye Ting, Su Zhaoliang, Zong Gangjun
OBJECTIVE: To establish human heart valve interstitial cells calcification culture model in vitro, and observe the effect of bone morphogenetic protein-2 (BMP-2) on calcification of human heart valve interstitial cells. METHODS: Human heart valve interstitial cells were cultured in vitro, and divided into control group: cells were cultured in conventional media plus recombinant human BMP-2 treatment and experimental group: besides above treaments, calcification inducers ( recombinant human BMP-2, β-glycerophosphate, L-ascorbic acid, dexamethasone) were added to the culture media...
August 2015: Zhonghua Xin Xue Guan Bing za Zhi
Jana Kolenda, Helge Fischer-Brandies, Robert Ciesielski, Bernd Koos
OBJECTIVES: The aim of this work was to evaluate associations of oral health-related quality of life (OHRQoL) with sociodemographic factors and with emotional state in adults after orthodontic treatment for anterior tooth alignment. Few studies have examined these specific associations in the past, one reason presumably being a lack of specific instruments. PATIENTS AND METHODS: A total of 128 adult patients consecutively treated with multibracket appliances were contacted during the retention period...
March 2016: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
Lena Andresen, Konstantina Theodorou, Sarah Grünewald, Bozena Czech-Zechmeister, Birte Könnecke, Fred Lühder, George Trendelenburg
Toll-like receptors (TLRs) are central sensors for the inflammatory response in ischemia-reperfusion injury. We therefore investigated whether TLR4 inhibition could be used to treat stroke in a standard model of focal cerebral ischemia. Anti-TLR4/MD2-antibody (mAb clone MTS510) blocked TLR4-induced cell activation in vitro, as reported previously. Here, different routes of MTS510 application in vivo were used to study the effects on stroke outcome up to 2d after occlusion of the middle cerebral artery (MCAO) for 45 min in adult male C57Bl/6 wild-type mice...
2016: PloS One
Christoph Fiehn
Methotrexate is in the centre of the treatment of rheumatoid arthritis. There are new insights in the understanding of its mechanism: intracellular polyglutamation activates the methotrexate molecule. The magnitude of this step is associated with response to the treatment. Further on, it was found that even low doses of methotrexate are sufficient to guarantee its effect as comedication of TNF-inhibitors. Finally, from the follow-up of long term cohorts it seems that methotrexate reduces mortality in rheumatoid arthritis independently from its effect on disease activity...
February 2016: Deutsche Medizinische Wochenschrift
Ján Baumgartner, Mária Šimaljaková, Pavel Babál
Angiokeratomas are rare vascular mucocutaneous lesions characterized by small-vessel ectasias in the upper dermis with reactive epidermal changes. Angiokeratoma circumscriptum (AC) is the rarest among the five types in the current classification of angiokeratoma. We present a case of an extensive AC in 19-year-old women with Fitzpatrick skin type I of the left lower extremity, characterized by a significant morphological heterogeneity of the lesions, intermittent bleeding, and negative psychological impact...
June 2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
Cui Zhao, Shuyuan Guo, Xiaoru Pang, Daozhen Song, Shijun Fu, Weishan Chang
OBJECTIVE: Nyctereutes procyonoides immunoglobulin G (IgG) gene is partially cloned. MATERIAL AND METHODS: In order to obtain a certain length (966bp) of Nyctereutes procyonoides immunoglobulin G (IgG), two pairs of primers are designed according to the conserved nucleotide sequence of canine (GenBank:AF354265, AF354265, AF354266, AF354267) and mink (GenBank: L07789). Using Bioinformatics technology and Western-blot to analyze antigenicity of Nyctereutes procyonoides IgG-B gene...
2015: Central-European Journal of Immunology
Lisa A Raedler
No abstract text is available yet for this article.
March 2015: American Health & Drug Benefits
Alberto Bazzocchi, Patrizia Pelotti, Salvatore Serraino, Milva Battaglia, Graziano Bettelli, Isabella Fusaro, Giuseppe Guglielmi, Roberto Rotini, Ugo Albisinni
OBJECTIVE: Rotator cuff calcific tendinitis (RCCT) is a common cause of shoulder pain in adults and typically presents as activity-related shoulder pain. Between non-surgical and surgical treatment options, today a few minimal invasive techniques are available to remove the calcific deposit, and they represent a cornerstone in the management of this painful clinical condition. The aim of the work was a retrospective evaluation of double-needle ultrasound-guided percutaneous fragmentation and lavage (DNL), focused on understanding the factors which are of major importance in determining a quick and good response at 1 month...
2016: British Journal of Radiology
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