keyword
https://read.qxmd.com/read/38523625/hospitalisation-expenditure-on-tuberculosis-among-tribal-populations-in-india-a-repeated-cross-sectional-analysis-of-national-sample-survey-data-2004-to-2018
#21
JOURNAL ARTICLE
Denny John, Jeetendra Yadav, Devdatta Ray, Paramita Bhattacharya, Nirmalya Mukherjee, Rajan Patil, Vivek Varma, Sahadeb Hembram, Moumita Hansda
OBJECTIVE: Tribal population in India (8.6% of the total population) have a greater prevalence of tuberculosis compared to the national average. The article aims to study out-of-pocket expenditure (OOPE), hardship financing, and impoverishment effects of TB hospitalisation treatment among tribal populations in India. METHODS: Data of three rounds of National Sample Surveys (NSS) 60th (2004-05), 71st (2013-14) and 75th (2017-18) rounds were analyzed. Descriptive statistics, bivariate estimates and multivariate models were performed to calculate the OOPE, healthcare burden (HCB), catastrophic health expenditure (CHE), hardship financing and impoverishment effects using standard definitions at February 2023 price values...
June 2024: Public health in practice
https://read.qxmd.com/read/38522856/severe-liver-dysfunction-after-donor-lymphocyte-infusion-for-relapsed-multiple-myeloma
#22
Tae-Hoon No, Nae-Yun Heo, Seung Ha Park, Joon Hyuk Choi, Junghwan Lee, Sung Nam Lim, Seon Yang Park
Donor lymphocyte infusion (DLI) is performed to augment an anti-tumor immune response or ensure donor stem cells remain engrafted following allogeneic stem cell transplantation but may induce graft-versus-host disease (GVHD) involving skin, intestine, and liver. Although hepatic involvement of GVHD can manifest as mild to severe hepatitis, few reports have mentioned acute severe liver dysfunction with encephalopathy. We experienced a case of acute severe liver dysfunction with semicoma after DLI in a patient with relapsed multiple myeloma following allogeneic stem cell transplantation, in whom chronic viral hepatitis B had been suppressed by antiviral treatment...
March 25, 2024: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://read.qxmd.com/read/38522281/sediment-source-fingerprints-of-natural-processes-and-anthropogenic-pressures-a-contribution-to-manage-the-paraopeba-river-basin-impacted-by-the-b1-tailings-dam-collapse
#23
JOURNAL ARTICLE
Carolina Acuna-Alonso, Renato Farias do Valle Junior, Mayte Maria Abreu Pires de Melo Silva, Teresa Cristina Tarlé Pissarra, Marília Carvalho de Melo, Carlos Alberto Valera, Luis Filipe Sanches Fernandes, Fernando António Leal Pacheco, Xana Álvarez
Understanding the origins of sediment transport in river systems is crucial for effective watershed management, especially after catastrophic events. This information is essential for the development of integrated strategies that guarantee water security in river basins. The present study aimed to investigate the rupture of the B1 tailings dam of the Córrego do Feijão mine, which drastically affected the Brumadinho region (Minas Gerais, Brazil). To address this issue, a confluence-based sediment fingerprinting approach was developed through the SedSAT model...
March 22, 2024: Journal of Environmental Management
https://read.qxmd.com/read/38522009/the-2023-report-of-the-mja-lancet-countdown-on-health-and-climate-change-sustainability-needed-in-australia-s-health-care-sector
#24
JOURNAL ARTICLE
Paul J Beggs, Stefan Trueck, Martina K Linnenluecke, Hilary Bambrick, Anthony G Capon, Ivan C Hanigan, Nicolas Borchers Arriagada, Troy J Cross, Sharon Friel, Donna Green, Maddie Heenan, Ollie Jay, Harry Kennard, Arunima Malik, Celia McMichael, Mark Stevenson, Sotiris Vardoulakis, Tran N Dang, Gail Garvey, Raymond Lovett, Veronica Matthews, Dung Phung, Alistair J Woodward, Marina B Romanello, Ying Zhang
The MJA-Lancet Countdown on health and climate change in Australia was established in 2017 and produced its first national assessment in 2018 and annual updates in 2019, 2020, 2021 and 2022. It examines five broad domains: health hazards, exposures and impacts; adaptation, planning and resilience for health; mitigation actions and health co-benefits; economics and finance; and public and political engagement. In this, the sixth report of the MJA-Lancet Countdown, we track progress on an extensive suite of indicators across these five domains, accessing and presenting the latest data and further refining and developing our analyses...
March 24, 2024: Medical Journal of Australia
https://read.qxmd.com/read/38521633/pain-mechanisms-for-the-practicing-rheumatologist
#25
REVIEW
Deeba Minhas
Pain in rheumatic diseases transcends the traditional nociceptive paradigm, incorporating complex interactions between nociceptive, neuropathic, and nociplastic mechanisms, as well as significant psychosocial factors. Advances in understanding chronic pain highlight the role of peripheral and central sensitization, and the emergence of nociplastic pain-a result of altered central nervous system processing. This modern perspective acknowledges the influence of mood disorders, environmental stressors, and cognitive patterns like catastrophizing, revealing the intricate interplay between biological, psychological, and social determinants of pain...
March 22, 2024: Best Practice & Research. Clinical Rheumatology
https://read.qxmd.com/read/38520119/hospital-admission-and-its-common-causes-in-children-on-antiretroviral-therapy-art-in-lilongwe-malawi-between-2001-and-2016-a-retrospective-cross-sectional-study
#26
JOURNAL ARTICLE
Samuel L Mpinganjira, Jonathan Chimkonda, Wonder Kishombe, Carmen Gonzalez-Martinez
BACKGROUND: Paediatric HIV data shows a variable and sometimes catastrophic response in the initial stage of ART regimen administration. The burden of disease that affects children in their first year of treatment is not comprehensively available. OBJECTIVE: Objective of our study was to describe patterns of admission in children; before ART initiation, within the first six months, and post-six months of ART between 2001 and 2016. METHODS: Principal caregivers of 260 children (45...
December 2024: HIV research & clinical practice
https://read.qxmd.com/read/38520049/pharmacological-degradation-of-atr-induces-antiproliferative-dna-replication-stress-in-leukemic-cells
#27
JOURNAL ARTICLE
Anita G Kansy, Ramy Ashry, Al-Hassan M Mustafa, Abdallah M Alfayomy, Markus P Radsak, Yanira Zeyn, Matthias Bros, Wolfgang Sippl, Oliver H Krämer
Mammalian cells replicate ~ 3 × 109 base pairs per cell cycle. One of the key molecules that slows down the cell cycle and prevents excessive DNA damage upon DNA replication stress is the checkpoint kinase ataxia-telangiectasia-and-RAD3-related (ATR). Proteolysis-targeting-chimeras (PROTACs) are an innovative pharmacological invention to molecularly dissect, biologically understand, and therapeutically assess catalytic and non-catalytic functions of enzymes. This work defines the first-in-class ATR PROTAC, Abd110/Ramotac-1...
March 22, 2024: Molecular Oncology
https://read.qxmd.com/read/38519441/management-and-outcomes-of-women-with-low-fibrinogen-concentration-during-pregnancy-or-immediately-postpartum-a-uk-national-population-based-cohort-study
#28
JOURNAL ARTICLE
Caroline Diguisto, Elfreda Baker, Simon Stanworth, Peter W Collins, Rachel E Collis, Marian Knight
INTRODUCTION: Pregnant women with a fibrinogen level <2 g/L represent a high-risk group that is associated with severe postpartum hemorrhage and other complications. Women who would qualify for fibrinogen therapy are not yet identified. MATERIAL AND METHODS: A population-based cross-sectional study was conducted using the UK Obstetric Surveillance System between November 2017 and October 2018 in any UK hospital with a consultant-led maternity unit. Any woman pregnant or immediately postpartum with a fibrinogen <2 g/L was included...
March 22, 2024: Acta Obstetricia et Gynecologica Scandinavica
https://read.qxmd.com/read/38518591/a-neoteric-antibacterial-ceria-silver-nanozyme-for-abiotic-surfaces
#29
JOURNAL ARTICLE
Abinaya Sindu Pugazhendhi, Craig J Neal, Khoa Minh Ta, Marco Molinari, Udit Kumar, Fei Wei, Elayaraja Kolanthai, Andrew Ady, Christina Drake, Megan Hughes, Shibu Yooseph, Sudipta Seal, Melanie J Coathup
Community-associated and hospital-acquired infections caused by bacteria continue to yield major global challenges to human health. Bacterial contamination on abiotic surfaces is largely spread via high-touch surfaces and contemporary standard disinfection practices show limited efficacy, resulting in unsatisfactory therapeutic outcomes. New strategies that offer non-specific and broad protection are urgently needed. Herein, we report our novel ceria-silver nanozyme engineered at a molar ratio of 5:1 and with a higher trivalent (Ce3+ ) surface fraction...
March 18, 2024: Biomaterials
https://read.qxmd.com/read/38517636/it-is-not-too-late-for-reconciliation-between-israel-and-palestine-even-in-the-darkest-hour
#30
JOURNAL ARTICLE
P A Komesaroff
The conflict in Gaza and Israel that ignited on October 7, 2023 signals a catastrophic breakdown in the possibility of ethical dialogue in the region. The actions on both sides have revealed a dissolution of ethical restraints, with unimaginably cruel attacks on civilians, murder of children, destruction of health facilities, and denial of basic needs such as water, food, and shelter. There is a need both to understand the nature of the ethical singularity represented by this conflict and what, if any, options are available to allow the reconstruction of communication between the warring parties...
March 22, 2024: Journal of Bioethical Inquiry
https://read.qxmd.com/read/38517037/enhanced-skin-burn-assessment-through-transfer-learning-a-novel-framework-for-human-tissue-analysis
#31
JOURNAL ARTICLE
Madhur Nagrath, Ashutosh Kumar Sahu, Nancy Jangid, Meghna Sharma, Poonam Chaudhary
Visual inspection is the typical way for evaluating burns, due to the rising occurrence of burns globally, visual inspection may not be sufficient to detect skin burns because the severity of burns can vary and some burns may not be immediately apparent to the naked eye. Burns can have catastrophic and incapacitating effects and if they are not treated on time can cause scarring, organ failure, and even death. Burns are a prominent cause of considerable morbidity, but for a variety of reasons, traditional clinical approaches may struggle to effectively predict the severity of burn wounds at an early stage...
March 22, 2024: Journal of Medical Engineering & Technology
https://read.qxmd.com/read/38515487/what-does-it-take-to-make-a-wrong-decision-a-qualitative-study-from-pakistan-s-health-sector
#32
JOURNAL ARTICLE
Mohsin Saeed Khan, Babar Tasneem Shaikh
BACKGROUND: Pakistan's health system over the past three decades has experienced social, economic, geopolitical instability, and notwithstanding man-made and natural catastrophes. Since 2001, the health system in Pakistan has undergone three phases of organizational and management reforms and does not have a unified national health policy since then. The aim of this research was to assess the factors behind the decision-making by policy planners in the health system of Pakistan. METHODS: An exploratory qualitative study based on grounded theory was designed where in-depth interviews conducted with 20 representatives of the political constituencies, civil bureaucracy, health planners and managers, research and educational institutions, NGOs providing technical support in the health sector, development partners and media...
December 2023: Dialogues Health
https://read.qxmd.com/read/38515468/the-effect-of-a-pilot-universal-health-coverage-program-on-hospital-workload-a-comparative-study-of-two-counties-in-kenya
#33
JOURNAL ARTICLE
John Njuguna
AIM: Universal health coverage (UHC) aims to provide individuals with the healthcare they need without predisposing them to catastrophic health expenditures. The Kenyan government piloted UHC in four select counties in 2019. Nyeri County was one of the selected counties. Area residents accessed health services from government-owned health facilities at no cost. This study assessed the effect of this pilot on the workload of major health facilities in Nyeri. MATERIAL AND METHODS: The monthly workload of six health facilities in Nyeri was compared with that of similar facilities in the non-participating county of Embu...
December 2023: Dialogues Health
https://read.qxmd.com/read/38515068/transforming-health-care-systems-towards-high-performance-organizations-qualitative-study-based-on-learning-from-covid-19-pandemic-in-the-basque-country-spain
#34
JOURNAL ARTICLE
Ane Fullaondo, Irati Erreguerena, Esteban de Manuel Keenoy
BACKGROUND: The COVID-19 pandemic is one of the worst health catastrophes of the last century, which caused severe economic, political, and social consequences worldwide. Despite these devastating consequences, lessons learned provide a great opportunity that can drive the reform of health systems to become high-performing, effective, equitable, accessible, and sustainable organisations. This work identifies areas in which changes must be encouraged that will enable health systems to deal effectively with current and future challenges, beyond COVID-19...
March 21, 2024: BMC Health Services Research
https://read.qxmd.com/read/38514803/the-nested-hierarchical-model-of-self-and-its-non-relational-vs-relational-posttraumatic-manifestation-an-fmri-meta-analysis-of-emotional-processing
#35
Andrea Scalabrini, Marco Cavicchioli, Francesco Benedetti, Clara Mucci, Georg Northoff
Different kinds of traumatic experiences like natural catastrophes vs. relational traumatic experiences (e.g., sex/physical abuse, interpersonal partner violence) are involved in the development of the self and PTSD psychopathological manifestations. Looking at a neuroscience approach, it has been proposed a nested hierarchical model of self, which identifies three neural-mental networks: (i) interoceptive; (ii) exteroceptive; (iii) mental. However, it is still unclear how the self and its related brain networks might be affected by non-relational vs relational traumatic experiences...
March 21, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38513698/out-of-pocket-expenditure-among-patients-with-diabetic-foot-ulcer-in-a-tertiary-care-hospital-of-south-india-a-cross-sectional-study
#36
JOURNAL ARTICLE
Hariharan Seshadri, Venkatesh Karthikeyan, Malavika Rudrakumar, Prashanth Seshadri, Damodaran Vasudevan, Vasuki Ranganathan, Tirth Dave, Victor Ghosh, Vadada Ramsai, Balakrishnan Kamaraj
Diabetic foot ulcer is a debilitating complication of long-standing diabetes mellitus. Patients lose their earning potential, face repeated hospitalizations, and are forced to bear heavy treatment costs. This places an enormous financial burden on the patients and their families. This study seeks to ascertain the out-of-pocket expenditure among these patients and correlate it with their risk factor profile. In this hospital-based cross-sectional study, a total of 154 patients with diabetic foot ulcers or amputations have been studied with an elaborate patient questionnaire and relevant clinical examinations...
April 2024: International Wound Journal
https://read.qxmd.com/read/38513063/tailored-yoga-intervention-for-postlumbar-spine-surgical-pain-management-a-feasibility-study
#37
JOURNAL ARTICLE
Neena K Sharma, Haiyin Li, Kosaku Aoyagi, Shannon Ritchey, Elisa Mohr, Douglas C Burton, Paul M Arnold, Yvonne Colgrove
Introduction: Severe pain, anxiety, and high opioid use are common following lumbar spine surgery (LSS). Yoga helps to reduce pain and anxiety, but it has not been considered for postsurgical care. The authors developed and tested the feasibility of a tailored yoga program designed for individuals undergoing LSS and explored clinical feasibility of yoga intervention on measures of pain, function, psychological status, and opioid use. Methods: Individuals scheduled for LSS were randomized into yoga versus control groups presurgery...
March 21, 2024: J Integr Complement Med
https://read.qxmd.com/read/38512478/pancytopenia-with-aplastic-anemia-in-systemic-lupus-erythematosus-case-series-and-literature-review
#38
REVIEW
Zaid Al-Ghazawi, Amwaj Al-Farajat, Ahmad A Toubasi, Hind B Abu Tawileh, Aya Qteish, Tariq N Aladily, Fatima Alnaimat
Aplastic anemia (AA) is a rare, potentially catastrophic hematopoiesis failure manifested by pancytopenia and bone marrow aplasia. AA occurrence in Systemic Lupus Erythematosus (SLE) patients is extremely rare. The diagnosis may be delayed due to other possible pancytopenia etiologies. Confirmation of peripheral cytopenias diagnosis necessitates a bone marrow aspiration. The management of AA is challenging, and the literature reported using glucocorticoids, danazol, plasmapheresis, cyclophosphamide, intravenous immunoglobulin, and cyclosporine...
March 21, 2024: Rheumatology International
https://read.qxmd.com/read/38512352/atomic-level-imaging-of-beam-sensitive-cofs-and-mofs-by-low-dose-electron-microscopy
#39
REVIEW
Zhen Zhan, Yuxin Liu, Weizhen Wang, Guangyu Du, Songhua Cai, Peng Wang
Electron microscopy, an important technique that allows for the precise determination of structural information with high spatiotemporal resolution, has become indispensable in unravelling the complex relationships between material structure and properties ranging from mesoscale morphology to atomic arrangement. However, beam-sensitive materials, particularly those comprising organic components such as metal-organic frameworks (MOFs) and covalent organic frameworks (COFs), would suffer catastrophic damage from the high energy electrons, hindering the determination of atomic structures...
March 21, 2024: Nanoscale Horizons: the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy
https://read.qxmd.com/read/38512073/diabetes-a-review-of-its-pathophysiology-and-advanced-methods-of-mitigation
#40
REVIEW
Sarika Gupta, Nitin Sharma, Sandeep Arora, Saurabh Verma
Diabetes mellitus (DM) is a long-lasting metabolic non-communicable disease often characterized by an increase in the level of glucose in the blood or hyperglycemia. Approximately, 415 million people between the ages of 20 and 79 years had DM in 2015 and this figure will rise by 200 million by 2040. In a study conducted by CARRS, it's been found that in Delhi the prevalence of diabetes is around 27% and for prediabetic cases, it is more than 46%. The disease DM can be both short-term and long-term and is often associated with one or more diseases like cardiovascular disease, liver disorder, or kidney malfunction...
March 21, 2024: Current Medical Research and Opinion
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