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https://www.readbyqxmd.com/read/27933590/three-dimensional-rotational-angiography-for-assessment-of-coronary-arteries-during-melody-valve-implantation-introducing-a%C3%A2-technique-that-may-improve-outcomes
#1
C R Pockett, J W Moore, H G El-Said
BACKGROUND: Adverse events from Melody valve implantation may be catastrophic. To date a role for three dimensional rotational angiography of the aortic root (3DRAA) during Melody valve implantation has not been established. OBJECTIVES: To describe the role of 3DRAA in the assessment of Melody valve candidacy and to demonstrate that it may improve outcomes. METHODS: All patients who underwent cardiac catheterisation for Melody valve implantation and 3DRAA between August 2013 and February 2015 were reviewed...
December 8, 2016: Netherlands Heart Journal
https://www.readbyqxmd.com/read/27933331/characterization-of-arsenic-biotransformation-by-a-typical-bryophyte-physcomitrella-patens
#2
Xixiang Yin, Lihong Wang, Yifei Liu, Tenglong Jiang, Jianwei Gao
Arsenic (As) is a ubiquitous environmental toxin that has created catastrophic human health and environmental problems around world. Physcomitrella patens is a potential model plant for the study of environmental monitoring, which exists in all kinds of ecosystems. In this study, arsenic metabolism was investigated by this moss. When supplied with different levels of arsenate (50, 100, 200 µmol/L) for a 4-week period, the total arsenic concentrations were up to 231.4-565.4 mg/kg DW in this moss. Arsenite concentration increased with increasing external arsenate concentrations, the proportion was up to 25...
December 8, 2016: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/27930535/family-dysfunction-a-comparison-of-chronic-widespread-pain-and-chronic-localized-pain
#3
Chie Hayaki, Kozo Anno, Mao Shibata, Rie Iwaki, Hiroshi Kawata, Nobuyuki Sudo, Masako Hosoi
Previous studies have shown differences in the psychosocial factors related to chronic localized pain (CLP) and chronic widespread pain (CWP). However, no studies have done an evaluation of differences between CLP and CWP from the viewpoint of family functioning. We did a cross-sectional study in a tertiary care setting to investigate possible differences in the relation of CWP and CLP to family functioning.Patients with CLP (N = 126) or CWP (N = 75) were assessed for family functioning by the Family Assessment Device (FAD) and a comparison was done...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27930392/pain-catastrophizing-is-not-associated-with-spinal-nociceptive-processing-in-people-with-chronic-widespread-pain
#4
David A Rice, Rosalind S Parker, Gwyn N Lewis, Michal T Kluger, Peter J McNair
OBJECTIVES: Pain catastrophizing has been associated with higher pain intensity, increased risk of developing chronic pain and poorer outcomes after pain treatments. Despite this, the mechanisms by which pain catastrophizing influences pain remain poorly understood. It has been hypothesised that pain catastrophizing may impair descending inhibition of spinal level nociception. The aims of this study were to compare spinal nociceptive processing in people with chronic widespread pain and pain free controls and examine potential relationships between measures of pain catastrophizing and spinal nociception...
December 7, 2016: Clinical Journal of Pain
https://www.readbyqxmd.com/read/27929277/acute-monoarthritis-diagnosis-in-adults
#5
Jonathan A Becker, Jennifer P Daily, Katherine M Pohlgeers
Acute monoarthritis can be the initial manifestation of many joint disorders. The most common diagnoses in the primary care setting are osteoarthritis, gout, and trauma. It is important to understand the prevalence of specific etiologies and to use the appropriate diagnostic modalities. A delay in diagnosis and treatment, particularly in septic arthritis, can have catastrophic results including sepsis, bacteremia, joint destruction, or death. The history and physical examination can help guide the use of laboratory and imaging studies...
November 15, 2016: American Family Physician
https://www.readbyqxmd.com/read/27928074/plasmodium-falciparum-resistance-to-artemisinin-derivatives-and-piperaquine-a-major-challenge-for-malaria-elimination-in-cambodia
#6
REVIEW
Valentine Duru, Benoit Witkowski, Didier Ménard
Artemisinin-based combination therapies (ACTs) are the cornerstone of current strategies for fighting malaria. Over the last decade, ACTs have played a major role in decreasing malaria burden. However, this progress is being jeopardized by the emergence of artemisinin-resistant Plasmodium falciparum parasites. Artemisinin resistance was first detected in western Cambodia in 2008 and has since been observed in neighboring countries in southeast Asia. The problem of antimalarial drug resistance has recently worsened in Cambodia, with reports of parasites resistant to piperaquine, the latest generation of partner drug used in combination with dihydroartemisinin, leading to worrying rates of clinical treatment failure...
December 7, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27927213/living-on-the-edge-substrate-competition-explains-loss-of-robustness-in-mitochondrial-fatty-acid-oxidation-disorders
#7
Karen van Eunen, Catharina M L Volker-Touw, Albert Gerding, Aycha Bleeker, Justina C Wolters, Willemijn J van Rijt, Anne-Claire M F Martines, Klary E Niezen-Koning, Rebecca M Heiner, Hjalmar Permentier, Albert K Groen, Dirk-Jan Reijngoud, Terry G J Derks, Barbara M Bakker
BACKGROUND: Defects in genes involved in mitochondrial fatty-acid oxidation (mFAO) reduce the ability of patients to cope with metabolic challenges. mFAO enzymes accept multiple substrates of different chain length, leading to molecular competition among the substrates. Here, we combined computational modeling with quantitative mouse and patient data to investigate whether substrate competition affects pathway robustness in mFAO disorders. RESULTS: First, we used comprehensive biochemical analyses of wild-type mice and mice deficient for medium-chain acyl-CoA dehydrogenase (MCAD) to parameterize a detailed computational model of mFAO...
December 7, 2016: BMC Biology
https://www.readbyqxmd.com/read/27926641/vaginal-hysterectomy-for-treatment-of-cervical-ectopic-pregnancy
#8
Roa Alammari, Renee Thibodeau, Oz Harmanli
BACKGROUND: Cervical ectopic pregnancy can lead to catastrophic hemorrhage, and may be managed conservatively with intra-amniotic methotrexate (MTX), systemic MTX, or both; surgical evacuation with or without balloon tamponade; and uterine artery embolization. However, some patients require hysterectomy, which has traditionally been performed abdominally. CASE: A 39-year-old parous woman was diagnosed with cervical ectopic pregnancy at an estimated 7 1/7 weeks of gestation...
December 2, 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27926616/passion-for-leisure-activity-contributes-to-pain-experiences-during-rehabilitation
#9
Anne Courbalay, Thomas Deroche, Britton Brewer
The primary aim of this study was to determine whether the levels of obsessive passion (OP) and harmonious passion for a suspended leisure activity contribute to pain catastrophizing and pain intensity in patients undergoing the rehabilitation process. The secondary aim was to examine whether the levels of passion associated with a maintained leisure activity offset the contribution of having a leisure activity suspended to pain intensity and catastrophizing. Ninety-one outpatients from functional rehabilitation units (Mage=37, SD=13...
December 6, 2016: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/27926485/axitinib-induces-senescence-associated-cell-death-and-necrosis-in-glioma-cell-lines-the-proteasome-inhibitor-bortezomib-potentiates-axitinib-induced-cytotoxicity-in-a-p21-waf-cip1-dependent-manner
#10
Maria Beatrice Morelli, Consuelo Amantini, Massimo Nabissi, Claudio Cardinali, Matteo Santoni, Giovanni Bernardini, Angela Santoni, Giorgio Santoni
Glioblastoma is associated with a poor overall survival despite new treatment advances. Antiangiogenic strategies targeting VEGF based on tyrosine kinase inhibitors (TKIs) are currently undergoing extensive research for the treatment of glioma.Herein we demonstrated that the TKI axitinib induces DNA damage response (DDR) characterized by γ-H2AX phosphorylation and Chk1 kinase activation leading to G2/M cell cycle arrest and mitotic catastrophe in U87, T98 and U251 glioma cell lines. Moreover, we found that p21(Waf1/Cip1) increased levels correlates with induction of ROS and senescence-associated cell death in U87 and T98 cell lines, which are reverted by N-acetyl cysteine pretreatment...
December 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27923943/venovenous-ecmo-support-in-an-infant-with-single-ventricle-physiology-and-catastrophic-pulmonary-venous-abnormalities
#11
Richard P Fernandez, Don Hayes, Patrick I McConnell, Darren Berman
Extracorporeal membrane oxygenation (ECMO) is an accepted treatment modality for life support refractory to conventional efforts in neonates with complex congenital heart lesions. Cannulation for ECMO can be accomplished by venovenous (VV) access where patients receive primarily respiratory support or venoarterial (VA) access which provides complete cardiopulmonary support. VV ECMO delivered by a single-vessel cannulation with a dual-chamber venous cannula allows for respiratory support while the patient remains dependent upon intrinsic cardiac function to support hemodynamics...
December 6, 2016: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/27920858/beware-of-positive-pressure-coronary-artery-air-embolism-following-percutaneous-lung-biopsy
#12
Dmitriy N Kazimirko, William B Beam, Khalid Saleh, Akash M Patel
Patients undergoing percutaneous lung biopsy are at risk of developing a systemic air embolism. Air embolism may manifest as a catastrophic iatrogenic event with ischemic insult to the end organs, with sites of least resistance such as coronary and cerebral circulation the most susceptible. We review the available literature and present a case of iatrogenic air embolism during computed tomography guided percutaenous lung biopsy under general anesthesia. Management, outcome, and periprocedural factors that may have contributed to the complication are discussed...
December 2016: Radiology case reports
https://www.readbyqxmd.com/read/27920847/liposarcoma-metastases-to-the-small-bowel-presenting-as-fat-density-intraluminal-lesions
#13
Steven P Rowe, Stephanie F Coquia, Pamela T Johnson, Elliot K Fishman
Metastatic disease to the small bowel is rare; however, it is important to recognize that when it does occurs a variety of complications are possible including obstruction, gastrointestinal bleeding, intussusception, and bowel perforation. We present here an unusual case of small bowel metastases in a patient with known metastatic liposarcoma in which the lesions manifested as rapidly evolving fat-density masses that necessitated segmental small bowel resection. Careful scrutiny of the small bowel in oncology patients is necessary to guide appropriate treatment and avoid potential catastrophic complications from small bowel metastases...
December 2016: Radiology case reports
https://www.readbyqxmd.com/read/27920720/validation-of-online-versions-of-tinnitus-questionnaires-translated-into-swedish
#14
Karolina Müller, Niklas K Edvall, Esma Idrizbegovic, Robert Huhn, Rilana Cima, Viktor Persson, Constanze Leineweber, Hugo Westerlund, Berthold Langguth, Winfried Schlee, Barbara Canlon, Christopher R Cederroth
Background: Due to the lack of objective measures for assessing tinnitus, its clinical evaluation largely relies on the use of questionnaires and psychoacoustic tests. A global assessment of tinnitus burden would largely benefit from holistic approaches that not only incorporate measures of tinnitus but also take into account associated fears, emotional aspects (stress, anxiety, and depression), and quality of life. In Sweden, only a few instruments are available for assessing tinnitus, and the existing tools lack validation...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27919776/state-versus-trait-validating-state-assessment-of-child-and-parental-catastrophic-thinking-about-children-s-acute-pain
#15
Hannah Durand, Kathryn A Birnie, Melanie Noel, Tine Vervoort, Liesbet Goubert, Katelynn E Boerner, Christine T Chambers, Line Caes
: Pain catastrophizing has emerged as one of the most robust predictors of child pain outcomes. Although assessments of state (i.e., situation-specific) pain catastrophizing in children and parents are often used, their psychometric properties are unknown. This study aimed to assess factor structure, reliability and predictive validity of state versions of Pain Catastrophizing Scales for children (PCS-C State) and parents (PCS-P State) relative to corresponding trait versions for child and parental pain-related outcomes...
December 2, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27919772/pain-anxiety-and-its-association-with-pain-congruence-trajectories-during-the-cold-pressor-task
#16
S M Clark, A Cano, L Goubert, J W S Vlaeyen, L H Wurm, A M Corley
: Incongruence of pain severity ratings among people experiencing pain and their observers has been linked to psychological distress. Previous studies have measured pain rating congruence through static self-report, involving a single rating of pain; however, this method does not capture changes in ratings over time. The present study examined the extent to which partners were congruent on multiple ratings of a participants' pain severity during the cold pressor task. Furthermore, two components of pain anxiety-pain catastrophizing and perceived threat-were examined as predictors of pain congruence...
December 2, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27919144/-manfredonia-southern-italy-a-continuous-catastrophe-newfound-citizenship-and-removal
#17
Giulia Malavasi
This article concerns the history of Manfredonia (Apulia Region, Southern Italy), linked to the petrochemical industry owned by Eni (from 1960s to 1990s). The city suffered not only an important accident occurred in 1976 with arsenic dissemination, but also a continuous catastrophe. In the 1980s, the popular movement contributed to an improved citizenship, but also to rifts and conflicts. The petrochemical impact on community determined disruption in domestic and social relationships, divided memory, and removal...
November 2016: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/27918375/treatments-and-other-prognostic-factors-in-the-management-of-the-open-abdomen-a-systematic-review
#18
Adam T Cristaudo, Scott B Jennings, Kerry Hitos, Ronny Gunnarsson, Alan DeCosta
BACKGROUND: The open abdomen (OA) is an important approach for managing intra-abdominal catastrophes and continues to be the standard of care. Despite this, challenges remain with it associated with a high incidence of complications and poor outcomes. The objective of this article is to perform a systematic review in accordance with PRISMA guidelines to identify prognostic factors in OA patients in regards to definitive fascial closure (DFC), mortality and intra-abdominal complications...
November 30, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27917298/lambl-s-excrescences-a-case-report-and-review-of-the-literature
#19
Haroon Kamran, Nirav Patel, Gagandeep Singh, Venu Pasricha, Moro Salifu, Samy I McFarlane
Lambl's excrescences are filamentous extensions of cardiac valves, mostly asymptomatic but rarely associated with catastrophic thromboembolic events such as acute ischemic stroke and acute coronary syndromes. Numerous case reports cited in the literature have addressed various spectrum of presentation of these syndromes and their outcomes based on therapies used. We encountered such a patient from our own experience who presented with an acute ischemic stroke with no other identifiable cause other than the Lambl's excrescences...
2016: Clinical Case Reports and Reviews
https://www.readbyqxmd.com/read/27916685/finding-the-right-fit-studying-the-biomechanics-of-under-tapping-with-varied-thread-depth-and-pitch
#20
Ehsan Jazini, Carmen Petraglia, Mark Moldavsky, Oliver Tannous, Tristan Weir, Comron Saifi, Omar Elkassabany, Yiwei Cai, Brandon Bucklen, Joseph O'Brien, Steven C Ludwig
BACKGROUND CONTEXT: Compromise of pedicle screw purchase is a concern in maintaining rigid spinal fixation, especially with osteoporosis. Little consistency exists among various tapping techniques. Pedicle screws are often prepared with taps of a smaller diameter, which can further exacerbate inconsistency. PURPOSE: To determine whether a mismatch between tap thread depth (D) and pitch (P) and screw thread D and P affects fixation when under-tapping in osteoporotic bone...
December 1, 2016: Spine Journal: Official Journal of the North American Spine Society
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