Tingting Zhou, Yi-Yun Ho, Ray X Lee, Amanda B Fath, Kathleen He, Jonathan Scott, Navdeep Bajwa, Nolan D Hartley, Jonathan Wilde, Xian Gao, Cui Li, Evan Hong, Matthew R Nassar, Ralf D Wimmer, Tarjinder Singh, Michael M Halassa, Guoping Feng
Optimizing behavioral strategy requires belief updating based on new evidence, a process that engages higher cognition. In schizophrenia, aberrant belief dynamics may lead to psychosis, but the mechanisms underlying this process are unknown, in part, due to lack of appropriate animal models and behavior readouts. Here, we address this challenge by taking two synergistic approaches. First, we generate a mouse model bearing point mutation in Grin2a ( Grin2a Y700X+/- ), a gene that confers high-risk for schizophrenia and was recently identified by large-scale exome sequencing...
January 9, 2024: bioRxiv