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Effect of neonatal phototherapy on

Douglas McG Clarkson, P Satodia, Ian Hadley
A routine review of light exposure within a neonatal intensive care unit is described following the introduction of a new model of neonatal phototherapy lamp. Spectral measurements were undertaken using a Bentham Dmc150 spectroradiometer system. Safety assessments were undertaken based on likely exposure of parents at the cot side, neonates in adjacent cots and the effectiveness of eye protection for neonates with direct phototherapy. An aphakic eye response was used for assessment of neonatal risk and the blue-light response for estimation of adult exposure using current ICNIRP guidelines...
September 19, 2016: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
Deepak Sharma, Nazanin Farahbakhsh, Pradeep Sharma, Sweta Shastri
BACKGROUND: Neonatal hyperbilirubinemia is frequently seen condition in the NICU. Oral zinc has been tried for the prevention of hyperbilirubinemia. AIMS: To evaluate the role of oral zinc supplementation for reduction of neonatal hyperbilirubinemia in term and preterm infants. METHOD: The literature search was done for various randomized control trial (RCT) by searching the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, EMBASE, Web of Science, Scopus, Index Copernicus, African Index Medicus (AIM), Thomson Reuters (ESCI), Chemical Abstracts Service (CAS) and other data base...
October 17, 2016: Journal of Maternal-fetal & Neonatal Medicine
A Cai, S Qi, Z Su, H Shen, Y Yang, W Cai, Y Dai
Phototherapy has been widely used in treating neonatal jaundice, but detailed metabonomic profiles of neonatal jaundice patients and response to phototherapy have not been characterized. Our aim was to depict the serum metabolic characteristics of neonatal jaundice patients relative to controls and changes in response to phototherapy. A (1) H nuclear magnetic resonance (NMR)-based metabonomic approach was employed to study the metabolic profiling of serum from healthy infants (n = 25) and from infants with neonatal jaundice (n = 30) pre- and postphototherapy...
August 2016: Clinical and Translational Science
Vinod K Bhutani, Ronald J Wong, David K Stevenson
Preterm neonates with increased bilirubin production loads are more likely to sustain adverse outcomes due to either neurotoxicity or overtreatment with phototherapy and/or exchange transfusion. Clinicians should rely on expert consensus opinions to guide timely and effective interventions until there is better evidence to refine bilirubin-induced neurologic dysfunction or benefits of bilirubin. In this article, we review the evolving evidence for bilirubin-induced brain injury in preterm infants and highlight the clinical approaches that minimize the risk of bilirubin neurotoxicity...
June 2016: Clinics in Perinatology
Afshin Safaei Asl, Marjaneh Zarkeshl, Abtin Heidarzadeh, Shohreh Maleknejad, Kaveh Hagikhani
Phototherapy is the most common, most effective, and least dangerous treatment method for neonatal hyperbilirubinemia and is the treatment of the first choice for neonatal icterus. Hypocalcemia is one of the lesser-known complications of phototherapy. Some studies have shown a relationship between increased urinary calcium excretion and phototherapy-induced hypocalcemia. We aimed to assess the effect of phototherapy on urinary calcium excretion in term neonates. This before-after study was performed on 80 term neonates having hyper- bilirubinemia referred to the 17(th) Shahrivar Hospital, Rasht, Guilan Province, Northern Iran, over a one-year period from May 2013 to May 2014...
May 2016: Saudi Journal of Kidney Diseases and Transplantation
Michel Boulvain, Olivier Irion, Therese Dowswell, Jim G Thornton
BACKGROUND: Women with a suspected large-for-dates fetus or a fetus with suspected macrosomia (birthweight greater than 4000 g) are at risk of operative birth or caesarean section. The baby is also at increased risk of shoulder dystocia and trauma, in particular fractures and brachial plexus injury. Induction of labour may reduce these risks by decreasing the birthweight, but may also lead to longer labours and an increased risk of caesarean section. OBJECTIVES: To assess the effects of a policy of labour induction at or shortly before term (37 to 40 weeks) for suspected fetal macrosomia on the way of giving birth and maternal or perinatal morbidity...
2016: Cochrane Database of Systematic Reviews
Mahmoud Rafieian-Kopaei, Abolfazl Khoshdel, Soleiman Kheiri, Rabin Shemian
INTRODUCTION: Consumption of cotoneaster may reduce neonatal jaundice. AIM: Hence this study was undertaken to determine the effect of mothers' cotoneaster consumption on treatment of their neonates' jaundice. MATERIALS AND METHODS: In this randomized clinical trial study, 120 neonates with jaundice referred to a hospital in southwest Iran were enrolled by nonprobability sampling and divided randomly into four groups. In the first group both mothers and neonates received cotoneaster; in the second group only mothers; in the third group only neonates; and in the fourth group the neonates received distilled water as placebo...
April 2016: Journal of Clinical and Diagnostic Research: JCDR
Cecilia A Mabogunje, Sarah M Olaifa, Bolajoko O Olusanya
Several clinical guidelines for the management of infants with severe neonatal hyperbilirubinemia recommend immediate exchange transfusion (ET) when the risk or presence of acute bilirubin encephalopathy is established in order to prevent chronic bilirubin encephalopathy or kernicterus. However, the literature is sparse concerning the interval between the time the decision for ET is made and the actual initiation of ET, especially in low- and middle-income countries (LMICs) with significant resource constraints but high rates of ET...
May 8, 2016: World Journal of Clinical Pediatrics
Martin Cremer, Kerstin Jost, Anna Gensmer, Isabelle Pramana, Edgar Delgado-Eckert, Urs Frey, Sven M Schulzke, Alexandre N Datta
Process C (internal clock) and Process S (sleep-wake homeostasis) are the basis of sleep-wake regulation. In the last trimester of pregnancy, foetal heart rate is synchronized with the maternal circadian rhythm. At birth, this interaction fails and an ultradian rhythm appears. Light exposure is a strong factor influencing the synchronization of sleep-wake processes. However, little is known about the effects of phototherapy on the sleep rhythm of premature babies. It was hypothesized that sleep in preterm infants would not differ during phototherapy, but that a maturation effect would be seen...
May 3, 2016: Journal of Sleep Research
Lucie Guilbaud, Charles Garabedian, Anne Cortey, Thameur Rakza, Bruno Carbonne, Véronique Houfflin-Debarge
OBJECTIVE: To compare in utero exchange transfusions (IUET) and in utero simple transfusions (IUST) for the treatment of fetal anemia resulting from red blood cell fetomaternal incompatibility. STUDY DESIGN: Retrospective comparative study from January 2006 through December 2011. The two techniques were compared for effectiveness, complications, and neonatal outcomes. RESULTS: 36 patients had 87 IUETs and 85 patients 241 IUSTs. Gestational age at the first transfusion was similar in both groups (IUET: 27±3...
June 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Michael W Kuzniewicz, Dina N Greene, Eileen M Walsh, Charles E McCulloch, Thomas B Newman
IMPORTANCE: The American Academy of Pediatrics treatment recommendations for neonatal jaundice are based on age-specific total serum bilirubin (TSB) levels. In May 2012, Ortho Clinical Diagnostics adjusted the calibrator values for Vitros Chemistry Products BuBc Slides (Ortho Clinical Diagnostics), a widely used method to quantify TSB, after concerns of positively biased results. OBJECTIVE: To investigate the association between recalibration of a reflectance spectrophotometry serum bilirubin assay and TSB levels and phototherapy use among newborns...
June 1, 2016: JAMA Pediatrics
Liron Borenstein-Levin, Dawod Sharif, Annat Amshalom, Arieh Riskin, Miri Hemo, Amen Khalil, David Bader, Amir Kugelman
BACKGROUND: Phototherapy has been reported to alter blood flow to various tissues. We hypothesized that during phototherapy the coronary blood flow will decrease because of a 'steal effect' to the periphery. OBJECTIVES: To evaluate the effects of phototherapy on coronary blood flow in healthy, jaundiced, term neonates. METHODS: Flow velocity [peak diastolic velocity (Vd)] and flow measures [diastolic time velocity integral (TVId) and flow index (FI)] in the left main (LM) and left anterior descending (LAD) coronary arteries were prospectively studied with 2D/pulsed Doppler ultrasound before, during and after phototherapy in 19 healthy term, jaundiced neonates (study group) and in matched nonjaundiced controls (25 neonates)...
2016: Neonatology
Abieyuwa A Emokpae, Cecilia A Mabogunje, Zainab O Imam, Bolajoko O Olusanya
BACKGROUND: A novel filtered-sunlight phototherapy (FSPT) device has been demonstrated to be safe and efficacious for treating infants with neonatal jaundice in resource-constrained tropical settings. We set out to provide baseline data for evaluating the clinical impact of this device in a referral pediatric hospital. METHODS: We reviewed the medical records of infants admitted for neonatal hyperbilirubinemia in an inner-city Children's Hospital in Lagos, between January 2012 and December 2014 to determine the pattern, treatment and outcomes during the pre-intervention period...
2016: PloS One
M K Ramadan, G Hussein, W Saheb, M Rajab, F G Mirza
OBJECTIVE: The study objective was to examine the effect of antenatal corticosteroids on the incidence of short-term neonatal morbidities in singletons born during the late preterm period. STUDY DESIGN: This was a prospective cohort study of singleton gestations at risk of imminent delivery between 34 0/7 and 36 6/7 weeks. Short-term neonatal morbidities were compared between the corticosteroid exposed and non-exposed groups. The rates of Neonatal Morbidity Composite and Any Adverse Neonatal Morbidity were then compared between the two groups...
2016: Journal of Neonatal-perinatal Medicine
Negin Salehi, Fereshte Bagheri, Hamid Ramezani Farkhani
INTRODUCTION: One of the most common pathologies in neonates is hyperbilirubinemia, which is a good marker for damage to the central nervous system. The sensitivity of the auditory system to bilirubin has been previously documented, with much discrepancy in its effects on Auditory Brainstem Response results. Thus the objective of this study was to evaluate the effects of hyperbilirubinemia on Auditory Brainstem Response of neonates treated with phototherapy. MATERIALS AND METHODS: Forty-two term neonates with hyperbilirubinemia, who underwent phototherapy participated in this cross sectional study...
January 2016: Iranian Journal of Otorhinolaryngology
Tina M Slusher, Bolajoko O Olusanya, Hendrik J Vreman, Ann M Brearley, Yvonne E Vaucher, Troy C Lund, Ronald J Wong, Abieyuwa A Emokpae, David K Stevenson
BACKGROUND: Sequelae of severe neonatal hyperbilirubinemia constitute a substantial disease burden in areas where effective conventional phototherapy is unavailable. We previously found that the use of filtered sunlight for the purpose of phototherapy is a safe and efficacious method for reducing total bilirubin. However, its relative safety and efficacy as compared with conventional phototherapy are unknown. METHODS: We conducted a randomized, controlled noninferiority trial in which filtered sunlight was compared with conventional phototherapy for the treatment of hyperbilirubinemia in term and late-preterm neonates in a large, urban Nigerian maternity hospital...
September 17, 2015: New England Journal of Medicine
A Tsibadze, E Chikvaidze, A Katsitadze, I Kvachadze, N Tskhvediani, A Chikviladze
Biological effect of a visible light depends on extend of its property to penetrate into the tissues: the greater is a wavelength the more is an effect of a radiation. An impact of a visible light on the skin is evident by wave and quantum effects. Quanta of a visible radiation carry more energy than infrared radiation, although an influence of such radiation on the skin is produced by the light spectrum on the boarder of the ultraviolet and the infrared rays and is manifested by thermal and chemical effects...
September 2015: Georgian Medical News
Mahmoud Af Kaabneh, Ghassan Sa Salama, Ayoub Ga Shakkoury, Ibrahim Mh Al-Abdallah, Afrah Alshamari, Ruba Aa Halaseh
OBJECTIVE: The objective of this study was to evaluate the effect of phenobarbital and phototherapy combination on the total serum bilirubin of the newborn infants with isoimmune hemolytic disease (IHD) and its impact on blood exchange transfusion rates. PATIENTS AND METHOD: This single-blinded, prospective, randomized, controlled trial was conducted between March 2013 and December 2014 at the pediatric ward of two Military Hospitals in Jordan. A total of 200 full-term neonates with IHD were divided randomly into two groups: (1) the phenobarbital plus phototherapy group (n = 103), and (2) the phototherapy-only group (n = 97)...
2015: Clinical Medicine Insights. Pediatrics
Lucas C Cardoso, Ranylson M L Savedra, Mariana M Silva, Giovana R Ferreira, Rodrigo F Bianchi, Melissa F Siqueira
The central process of neonatal phototherapy by employing blue light has been attributed to the configurational conversion of (4Z,15Z)-bilirubin to (4Z,15E). Indeed, photoisomerization is the early photochemical event during this procedure. However, in this paper, we show that the bilirubin solutions under continuous blue light exposure undergo a photooxidation process. To ascertain the role of this photodegradation in the phototherapy, we evaluated UV–visible absorption spectra obtained from bilirubin solutions in CHCl3, milli-Q water, and physiological saline, as well as FTIR spectroscopy for bilirubin in CHCl3...
August 27, 2015: Journal of Physical Chemistry. A
Michele Mussap, Elisabetta Puxeddu, Melania Puddu, Giovanni Ottonello, Ferdinando Coghe, Paola Comite, Francesco Cibecchini, Vassilios Fanos
Neonatal sepsis still remains a major cause of morbidity and mortality in neonatal intensive care unit (NICU). Recently, soluble CD14 subtype (sDC14-ST) also named presepsin, was proposed as an effective biomarker for diagnosing, monitoring, and assessing the risk of neonatal sepsis and septic shock. The aim of this study was to investigate the diagnostic accuracy of sCD14-ST presepsin in diagnosing neonatal bacterial sepsis and in discriminating non-bacterial systemic inflammatory response syndrome (SIRS) from bacterial sepsis...
December 7, 2015: Clinica Chimica Acta; International Journal of Clinical Chemistry
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