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https://www.readbyqxmd.com/read/27898350/cronkhite-canada-syndrome-complicated-by-pulmonary-embolism-a-case-report
#1
Neha L Nemade, Urvi B Shukla, Gajanan D Wagholikar
INTRODUCTION: Cronkhite Canada Syndrome (CCS) is a rare syndrome, described in 1955 by Americans, Leonard Wolsey Cronkhite and Wilma Jeanne Canada in the New England Journal of Medicine [1]. About 450 cases have been reported. Complications, like malignant transformation, unprovoked thromboembolism is known. Since there is wide variability in medical presentation, no definitive diagnostic and treatment protocol s have been set. The mortality remains at 55%. CASE PRESENTATION: We report a case of a 50 year old male patient presenting with diarrhea, weight loss, abdominal pain, ectodermal features...
November 17, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27858205/statistical-inference-in-abstracts-of-major-medical-and-epidemiology-journals-1975-2014-a-systematic-review
#2
REVIEW
Andreas Stang, Markus Deckert, Charles Poole, Kenneth J Rothman
Since its introduction in the twentieth century, null hypothesis significance testing (NHST), a hybrid of significance testing (ST) advocated by Fisher and null hypothesis testing (NHT) developed by Neyman and Pearson, has become widely adopted but has also been a source of debate. The principal alternative to such testing is estimation with point estimates and confidence intervals (CI). Our aim was to estimate time trends in NHST, ST, NHT and CI reporting in abstracts of major medical and epidemiological journals...
November 17, 2016: European Journal of Epidemiology
https://www.readbyqxmd.com/read/27855102/non-inferiority-trials-are-they-inferior-a-systematic-review-of-reporting-in-major-medical-journals
#3
Sunita Rehal, Tim P Morris, Katherine Fielding, James R Carpenter, Patrick P J Phillips
OBJECTIVE: To assess the adequacy of reporting of non-inferiority trials alongside the consistency and utility of current recommended analyses and guidelines. DESIGN: Review of randomised clinical trials that used a non-inferiority design published between January 2010 and May 2015 in medical journals that had an impact factor >10 (JAMA Internal Medicine, Archives Internal Medicine, PLOS Medicine, Annals of Internal Medicine, BMJ, JAMA, Lancet and New England Journal of Medicine)...
October 7, 2016: BMJ Open
https://www.readbyqxmd.com/read/27852915/levels-of-influence-habituation-and-the-prevalence-of-declared-conflicts-of-interest
#4
REVIEW
Jillian R H Bernstein, George Maliha, Jaimo Ahn, Joseph Bernstein
BACKGROUND: The International Committee of Medical Journal Editors has devised a system of mandatory disclosure, under which authors are required to disclose all conflicts of interest and the sources of support for the submitted research. Because payments from industry to physicians generally are common, it is likely that many authors of medical manuscripts will have information to disclose. As a result, the signal-to-noise ratio of such declarations may be low, thereby undermining the effectiveness of disclosure...
November 16, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27757242/no-difference-found-in-time-to-publication-by-statistical-significance-of-trial-results-a-methodological-review
#5
L Jefferson, C Fairhurst, E Cooper, C Hewitt, T Torgerson, L Cook, P Tharmanathan, S Cockayne, D Torgerson
OBJECTIVE: Time-lag from study completion to publication is a potential source of publication bias in randomised controlled trials. This study sought to update the evidence base by identifying the effect of the statistical significance of research findings on time to publication of trial results. DESIGN: Literature searches were carried out in four general medical journals from June 2013 to June 2014 inclusive (BMJ, JAMA, the Lancet and the New England Journal of Medicine)...
October 2016: JRSM Open
https://www.readbyqxmd.com/read/27651214/commercial-conflict-of-interest-and-medical-publication-what-should-the-practising-physician-do-about-it
#6
Prem Pais
I read with interest the comment by Mark Wilson, which deals with possible conflict of interest (CoI) affecting publications in academic medical journals. This comment has specifically targeted the New England Journal of Medicine (NEJM) and its editor-in-chief Jeffrey Drazen on the "Vioxx scandal" which broke 15 years ago. Wilson's comment seems to be in response to a blog by Natarajan on CoI in medical publications. In the blog Natarajan writes of commercial CoI biasing publication of clinical trials and cites, among other examples, a publication in the NEJM on trials of voriconazole...
October 2016: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/27650969/chromosomal-microarray-testing-in-adults-with-intellectual-disability-presenting-with-comorbid-psychiatric-disorders
#7
Kate Wolfe, André Strydom, Deborah Morrogh, Jennifer Carter, Peter Cutajar, Mo Eyeoyibo, Angela Hassiotis, Jane McCarthy, Raja Mukherjee, Dimitrios Paschos, Nagarajan Perumal, Stephen Read, Rohit Shankar, Saif Sharif, Suchithra Thirulokachandran, Johan H Thygesen, Christine Patch, Caroline Ogilvie, Frances Flinter, Andrew McQuillin, Nick Bass
Chromosomal copy-number variations (CNVs) are a class of genetic variants highly implicated in the aetiology of neurodevelopmental disorders, including intellectual disabilities (ID), schizophrenia and autism spectrum disorders (ASD). Yet the majority of adults with idiopathic ID presenting to psychiatric services have not been tested for CNVs. We undertook genome-wide chromosomal microarray analysis (CMA) of 202 adults with idiopathic ID recruited from community and in-patient ID psychiatry services across England...
September 21, 2016: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/27637413/reporting-on-data-monitoring-committees-in-neonatal-randomised-controlled-trials-is-inconsistent
#8
L M Perrem, S Gosling, I Ravikumar, A S Khashan, J Miletin, C A Ryan, E Dempsey
AIM: To evaluate the reported use of Data Monitoring Committees (DMCs), the frequency of interim analysis, pre-specified stopping rules and early trial termination in neonatal randomised controlled trials (RCTs). METHODS: We reviewed neonatal RCTs published in four high impact general medical journals, specifically looking at safety issues including documented involvement of a DMC, stated interim analysis, stopping rules and early trial termination. We searched all journal issues over an 11-year period (2003-2013) and recorded predefined parameters on each item for RCTs meeting inclusion criteria...
September 16, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27608487/vioxx-redux-or-how-i-learned-to-worry-about-industry-sponsored-clinical-trials
#9
James M Brophy
I read with interest Mark Wilson's recent article, "The New England Journal of Medicine: commercial conflict of interest and revisiting the Vioxx scandal". I believe this is an important contribution that underlines the aphorism "Those who don't know history are doomed to repeat it." As Vioxx is a seminal example, it is important to place it in its proper context, examining if this malfeasance extends beyond the VIGOR study. While the epicentre of this conflict of interest surely begins with the sponsor, I believe the following essay demonstrates that this wave of egregiously unethical behaviour can exist and be propagated only with the complicity of academic investigators, medical journals, a flawed peer-review system and an uncritical medical readership...
October 2016: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/27604162/journal-bias-or-author-bias
#10
Ian Harris
I read with interest the comment by Mark Wilson in the Indian Journal of Medical Ethics regarding bias and conflicts of interest in medical journals. Wilson targets one journal (the New England Journal of Medicine: NEJM) and one particular "scandal" to make his point that journals' decisions on publication are biased by commercial conflicts of interest (CoIs). It is interesting that he chooses the NEJM which, by his own admission, had one of the strictest CoI policies and had published widely on this topic...
August 24, 2016: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/27552584/the-most-cited-articles-in-coronary-heart-disease-a-bibliometric-analysis-between-1970-and-2015
#11
Jiangquan Liao, Jie Wang, Yongmei Liu, Jun Li, Qingyong He, Wenrui Jiang, Yan Dong
BACKGROUND: Research on coronary heart disease (CHD) remains one of the major concerns in the medical and health fields in recent decades, yet data on the circumstances of CHD are unsatisfying. We aimed to evaluate the situations and trends of the most cited articles in CHD via bibliometric approaches. METHODS AND RESULTS: The Web of Science database was used to identify the 100 most cited articles concerning CHD. General and bibliometric information was collected and analyzed...
November 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27499485/henry-knowles-beecher-jay-katz-and-the-transformation-of-research-with-human-beings
#12
Alexander Morgan Capron
The modern history of experimentation with human beings is notable for its ethical lacunae, when even the clearest directives fail to prevent violations of subjects' rights and welfare. One such lacuna occurred during the 25 years between 1947, when the Nuremberg Code was articulated in the judgment passed on the men who had performed medical experiments in the Nazi concentration camps, and 1972, when the revelation of the 40-year-long Tuskegee Syphilis Study shocked the public and pushed Congress to adopt legislation that eventually transformed the governance of human subjects research...
2016: Perspectives in Biology and Medicine
https://www.readbyqxmd.com/read/27490462/impact-factors-and-prediction-of-popular-topics-in-a-journal
#13
M B Nielsen, K Seitz
The impact factor (IF) for 2015 was recently released and this could be the time to once again reflect on its use as a metric of a journal. Problems and concerns regarding the IF have been addressed extensively elsewhere 1 2. The principle of the IF for a given year is that it represents the average number of citations of articles published in the journal in the two previous years.While authors frequently cite the IF as a determining factor for submission, the IF does not predict how many times individual articles will be cited...
August 2016: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/27470506/reporting-quality-of-randomised-controlled-trial-abstracts-among-high-impact-general-medical-journals-a-review-and-analysis
#14
Meredith Hays, Mary Andrews, Ramey Wilson, David Callender, Patrick G O'Malley, Kevin Douglas
OBJECTIVE: The aim of this study was to assess adherence to the Consolidated Standards of Reporting Trials (CONSORT) for Abstracts by five high-impact general medical journals and to assess whether the quality of reporting was homogeneous across these journals. DESIGN: This is a descriptive, cross-sectional study. SETTING: Randomised controlled trial (RCT) abstracts in five high-impact general medical journals. PARTICIPANTS: We used up to 100 RCT abstracts published between 2011 and 2014 from each of the following journals: The New England Journal of Medicine (NEJM), the Annals of Internal Medicine (Annals IM), The Lancet, the British Medical Journal (The BMJ) and the Journal of the American Medical Association (JAMA)...
July 28, 2016: BMJ Open
https://www.readbyqxmd.com/read/27466238/hundred-top-cited-articles-focusing-on-acute-kidney-injury-a-bibliometric-analysis
#15
Yuan-Hui Liu, Sheng-Qi Wang, Jin-Hua Xue, Yong Liu, Ji-Yan Chen, Guo-Feng Li, Peng-Cheng He, Ning Tan
BACKGROUND: Acute kidney injury (AKI) is a major global health issue, associated with poor short-term and long-term outcomes. Research on AKI is increasing with numerous articles published. However, the quantity and quality of research production in the field of AKI is unclear. METHODS AND ANALYSIS: To analyse the characteristics of the most cited articles on AKI and to provide information about achievements and developments in AKI, we searched the Science Citation Index Expanded for citations of AKI articles...
July 27, 2016: BMJ Open
https://www.readbyqxmd.com/read/27445445/understanding-recent-home-birth-research-an-interview-with-drs-melissa-cheyney-and-jonathan-snowden
#16
Melissa Cheyney
In the past month, two new studies have been released-one in The New England Journal of Medicine (NEJM; Snowden et al., 2015) and the other in the Canadian Medical Association Journal (Hutton et al., 2015)-comparing out-of-hospital birth outcomes to hospital birth outcomes. These studies join a growing body of literature that consistently shows high rates of obstetric intervention in hospitals and also show low risk to neonates regardless of setting. However, the recent NEJM study found a small but statistically significant increase in risk for perinatal mortality for babies born out of hospital...
2016: Journal of Perinatal Education
https://www.readbyqxmd.com/read/27348431/the-new-england-journal-of-medicine-commercial-conflict-of-interest-and-revisiting-the-vioxx-scandal
#17
Mark Wilson
At a recent cardiology conference in New Delhi, the cardiologist Deepak Natarajan raised the concern that commercial conflicts of interest (COIs) were corrupting medical journals. Natarajan cited "manipulated" publications in The New England Journal of Medicine (NEJM) as one example to support his view. His comments were met with silence and an air of indignation. Natarajan's medical colleagues were stunned, disbelieving, and then, angry.
July 2016: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/27297119/the-cohabitation-of-academia-and-industry-what-position-do-the-medical-journals-take-regarding-opinion-articles
#18
R Dal-Ré, X Carné
Should medical journals publish editorials and educational articles written by authors who have financial conflicts of interest with pharmaceutical and biotechnology industries on whose products (or their competitors) they discuss? In the last 18 months, a controversy was sparked between The New England Journal of Medicine and BMJ, who took 2 opposite positions: the former stated that the negative bias against authors with conflicts of interest with industry is excessive and therefore accept articles from any expert, ensuring that they have the minimum possible bias...
June 10, 2016: Revista Clínica Española
https://www.readbyqxmd.com/read/27238631/assessing-validity-of-observational-intervention-studies-the-benchmarking-controlled-trials
#19
Antti Malmivaara
BACKGROUND: Benchmarking Controlled Trial (BCT) is a concept which covers all observational studies aiming to assess impact of interventions or health care system features to patients and populations. AIMS: To create and pilot test a checklist for appraising methodological validity of a BCT. METHODS: The checklist was created by extracting the most essential elements from the comprehensive set of criteria in the previous paper on BCTs. Also checklists and scientific papers on observational studies and respective systematic reviews were utilized...
May 29, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27149908/bridging-the-academia-industry-chasm-proposed-solutions
#20
Paul Beninger, Marcia Boumil, Deeb Salem, Kenneth Getz, Henry Klapholz, Gregory D Curfman, Rohan Jotwani, Harris Berman
No abstract text is available yet for this article.
December 2016: Journal of Clinical Pharmacology
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