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https://www.readbyqxmd.com/read/28653802/safety-profile-of-h1-antihistamines-in-pediatrics-an-analysis-based-on-data-from-vigibase
#1
Domenico Motola, Monia Donati, Chiara Biagi, Elisabetta Calamelli, Francesca Cipriani, Mauro Melis, Luca Monaco, Alberto Vaccheri, Giampaolo Ricci
PURPOSE: H1-antihistamines are commonly used in infants and children for the relief of histamine-mediated symptoms in a variety of conditions. Little is known about their safety profile in these patients. We performed a comparative analysis of the safety profiles of H1-antihistamines using data from the WHO database (VigiBase). METHODS: We selected adverse drug reaction (ADR) reports on H1-antihistamines in children (0-16 years) up to June 2014 from VigiBase. ADRs were codified according to MedDRA terminology...
October 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28441993/randomized-placebo-controlled-study-of-cetirizine-and-loratadine-in-children-with-seasonal-allergic-rhinitis
#2
Anjuli S Nayak, William E Berger, Craig F LaForce, Eduardo R Urdaneta, Mitesh K Patel, Kathleen B Franklin, Mei-Miau Wu
BACKGROUND: Pharmacologic treatment is a mainstay of allergy therapy and many caregivers use over-the-counter antihistamines for the treatment of seasonal allergic rhinitis (SAR) symptoms in children. OBJECTIVE: To assess the efficacy and safety of cetirizine 10 mg syrup versus loratadine 10 mg syrup versus placebo syrup in a randomized double-blind study of children, ages 6-11 years, with SAR. METHODS: This randomized, double-blind, parallel-group, placebo-controlled study was conducted at 71 U...
May 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28270216/bifidobacterium-mixture-b-longum-bb536-b-infantis-m-63-b-breve-m-16v-treatment-in-children-with-seasonal-allergic-rhinitis-and-intermittent-asthma
#3
Michele Miraglia Del Giudice, Cristiana Indolfi, Michele Capasso, Nunzia Maiello, Fabio Decimo, Giorgio Ciprandi
BACKGROUND: Allergic rhinitis (AR) and allergic asthma are caused by an IgE-mediated inflammatory reaction. Probiotics may exert anti-inflammatory and immune-modulatory activity. Thus, this study aimed at investigating whether a Bifidobacteria mixture could be able to relieve nasal symptoms, and affect quality of life (QoL) in children with AR and intermittent asthma due to Parietaria allergy. MATERIALS AND METHODS: The present study was conducted as placebo-controlled, double-blinded, and randomized...
March 7, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28127315/relationship-between-different-types-and-forms-of-anti-asthmatic-medications-and-dental-caries-in-three-to-12-year-olds
#4
Alireza Heidari, Bahman Seraj, Mahdi Shahrabi, Hamideh Maghsoodi, Mohammad Javad Kharazifard, Tara Zarabian
OBJECTIVES: Asthma is a common chronic disease. Asthma and anti-asthmatic medications have been suggested as risk factors for increased susceptibility to caries. This study was conducted to evaluate the effects of different types and forms of antihistaminic medications and the duration of drug consumption on the severity of dental caries in asthmatic children. MATERIALS AND METHODS: This cross-sectional study was conducted in Asthma and Allergy Department of Children's Medical Center in Tehran, Iran...
August 2016: Journal of Dentistry of Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/27999602/anaphylaxis-to-supplemental-oral-lactase-enzyme
#5
M R Voisin, R Borici-Mazi
BACKGROUND: Anaphylactic reactions involving IgE mediated hypersensitivity have been frequently reported for a number of uncommon foods. However, cases of anaphylaxis to over the counter vitamins and oral supplements have been rarely published. Lactose intolerance affects approximately 20% of Canadians and roughly 70% of the world's population of any age. Lactose intolerance develops primarily due to the absence of the enzyme lactase and treatment involves avoidance of lactose-containing foods or ingestion of commercially available lactase enzyme preparations prior to their consumption...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27872863/attention-deficit-disorder-and-allergic-rhinitis-are-they-related
#6
Isaac Melamed, Melinda Heffron
The association between ADHD and allergy remains controversial. Our previous findings suggest that nerve growth factor may link the nervous and immune systems. The primary objective of this study was to determine if a combination of cetirizine + methylphenidate is effective in children with comorbid ADHD and allergic rhinitis. We also examined the role of nerve growth factor in these comorbidities. Our randomized, double-blind, placebo-controlled, crossover study enrolled 38 children diagnosed with comorbid ADHD and allergy using cetirizine (n = 12), sustained-release methylphenidate (n = 12), or cetirizine + methylphenidate (n = 14)...
2016: Journal of Immunology Research
https://www.readbyqxmd.com/read/27540235/patient-carers-recollection-of-medicines-related-information-from-an-out-patient-clinic-appointment
#7
Jeff Aston, Natasha Patel, Justin Smuels, Teena Aujla, Georgia Malesi, Chi Huynh, Keith Wilson, David Terry
AIM: To identify what medicines related information children/young people or their parents/carers are able to recall following an out-patient clinic appointment. METHOD: A convenience sample of patients' prescribed at least one new long-term (>6 weeks) medicine were recruited from a single UK paediatric hospital out-patient pharmacy.A face-to-face semi-structured questionnaire was administered to participants when they presented with their prescription. The questionnaire included the following themes: names of the medicines, therapeutic indication, dose regimen, duration of treatment and adverse effects...
September 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27075562/suitability-of-e-tongue-sensors-to-assess-taste-masking-of-pediatric-liquids-by-different-beverages-considering-their-physico-chemical-properties
#8
Laura Isabell Immohr, Claas Hedfeld, Artur Lang, Miriam Pein-Hackelbusch
Manipulation of liquid oral drugs by mixing them into foodstuff is a common procedure for taste-masking of OTC pharmaceuticals when administered to children. However, the taste-masking capability of such application media is not systematically evaluated, and recommendations for suitable media are hardly published. In this study, a sensor array of commercially available and self-developed electronic tongue sensors was employed to assess the taste-masking efficiency of eight different beverages (tap water, apple juice, carrot juice, fennel tea, fruit tea, milk, cocoa, and Alete meal to drink) on the OTC pharmaceuticals Ambroxol-ratiopharm®, Cetirizin AL, and Laxoberal® by multivariate data analysis...
February 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/26844216/a-stepwise-approach-in-the-management-of-chronic-spontaneous-urticaria-in-children
#9
Xin Hui Magdeline Lee, Lin Xin Ong, Jing Yi Vanessa Cheong, Rehena Sultana, Rajeshwar Rao, Hwee Hoon Lim, Xiao Mei Ding, Wen Yin Loh, Monika Punan, Wen Chin Chiang
BACKGROUND: There is limited literature in the management of chronic urticaria in children. Treatment algorithms are generally extrapolated from adult studies. OBJECTIVE: Utility of a weight and age-based algorithm for antihistamines in management of chronic spontaneous urticaria (CSU) in childhood. To document associated factors that predict for step of control of CSU and time taken to attain control of symptoms in children. METHODS: A workgroup comprising of allergists, nurses, and pharmacists convened to develop a stepwise treatment algorithm in management of children with CSU...
January 2016: Asia Pacific Allergy
https://www.readbyqxmd.com/read/25183635/demographic-and-clinical-profiles-in-patients-with-acute-urticaria
#10
M Sánchez-Borges, A Capriles-Hulett, F Caballero-Fonseca
BACKGROUND: Urticaria is a common cause for consultation in general and specialised medical practices. There is scarce information on the characteristics of patients suffering acute urticaria in Latin America. OBJECTIVES: To investigate demographic and clinical features of patients with acute urticaria attending two allergy clinics in Caracas, Venezuela. METHODS: A prospective study of all new patients who consulted during a three-year period because of acute urticaria...
July 2015: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/25164591/review-of-italian-primary-care-paediatricians-identifies-38-commonly-prescribed-drugs-for-children
#11
Daniele Piovani, Antonio Clavenna, Maurizio Bonati
AIM: Most Italian children are cared for by a family paediatrician until they are 14 years old, and their duties include prescribing drugs recommended by specialists so that they are free. This study aimed to draw up a list of the drugs most commonly prescribed by family paediatricians. METHODS: We surveyed 64 experienced family paediatricians to find out what drugs they prescribed over an 8-week period, including those recommended by a specialist, using cartons of drugs as the unit of measurement...
December 2014: Acta Paediatrica
https://www.readbyqxmd.com/read/24983742/resveratrol-plus-carboxymethyl-%C3%AE-glucan-reduces-nasal-symptoms-in-children-with-pollen-induced-allergic-rhinitis
#12
RANDOMIZED CONTROLLED TRIAL
Michele Miraglia Del Giudice, Nunzia Maiello, Carlo Capristo, Emilia Alterio, Michele Capasso, Laura Perrone, Giorgio Ciprandi
OBJECTIVE: Allergic rhinitis (AR) is caused by an IgE-mediated inflammatory reaction consequent to the exposure to causal allergen. Resveratrol is a natural non-flavonoid polyphenol, exerting anti-inflammatory activity; β-glucan is a polysaccharide with immuno-modulatory properties. Thus, this study aimed to investigate whether these combined compounds are able of relieving nasal symptoms in children with AR due to pollen allergy. RESEARCH DESIGN AND METHODS: The present study was conducted as placebo-controlled, double-blinded, and randomized...
October 2014: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/24664098/stabbing-headache-in-an-8-year-old-girl-primary-or-drug-induced-headache
#13
Agnieszka Biedroł, Marek Kaciłski, Barbara Skowronek-Bała
The occurrence of stabbing headaches in children requires a thorough diagnostic approach that excludes secondary headaches. The organic background should be taken into consideration when alarming symptoms occur, such as a purely 1-sided location, a change in the character of the headache, or possibly a link to physical activity. The current study describes the case of an 8-year-old girl who suffered short-lasting stabbing headache attacks. The headaches with increasing intensity and frequency started 1 month before her hospitalization and were usually preceded by physical activity (dancing, running)...
April 2014: Pediatrics
https://www.readbyqxmd.com/read/24568362/an-egyptian-child-with-erythromelalgia-responding-to-a-new-line-of-treatment-a-case-report-and-review-of-the-literature
#14
Samir M Al-Minshawy, Abdel-Azeem M El-Mazary
INTRODUCTION: Erythromelalgia is a rare clinical syndrome characterized by episodic erythema, warmth and intense burning pain, which commonly involves the extremities. For those affected, this disorder may lead to significant long-term morbidity. Unfortunately, to date, no definitive therapy is available. This case report describes an Egyptian child with primary erythromelalgia that manifested at an early age and showed partial response to therapy with cetirizine hydrochloride. This anecdotal case report may have a diagnostic value for clinicians who have not seen this disorder...
2014: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/24446276/signal-detection-of-potentially-drug-induced-acute-liver-injury-in-children-using-a-multi-country-healthcare-database-network
#15
Carmen Ferrajolo, Preciosa M Coloma, Katia M C Verhamme, Martijn J Schuemie, Sandra de Bie, Rosa Gini, Ron Herings, Giampiero Mazzaglia, Gino Picelli, Carlo Giaquinto, Lorenza Scotti, Paul Avillach, Lars Pedersen, Francesco Rossi, Annalisa Capuano, Johan van der Lei, Gianluca Trifiró, Miriam C J M Sturkenboom
BACKGROUND: Data mining in spontaneous reporting databases has shown that drug-induced liver injury is infrequently reported in children. OBJECTIVES: Our objectives were to (i) identify drugs potentially associated with acute liver injury (ALI) in children and adolescents using electronic healthcare record (EHR) data; and (ii) to evaluate the significance and novelty of these associations. METHODS: We identified potential cases of ALI during exposure to any prescribed/dispensed drug for individuals <18 years old from the EU-ADR network, which includes seven databases from three countries, covering the years 1996-2010...
February 2014: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/23972320/effect-of-combination-of-montelukast-and-levocetirizine-on-otitis-media-with-effusion-a-prospective-placebo-controlled-trial
#16
RANDOMIZED CONTROLLED TRIAL
Cigdem Kalaycik Ertugay, Cemal Cingi, Aytekin Yaz, Turhan San, Seckin Ulusoy, Nagehan Erdogmus, Omer Cagatay Ertugay
CONCLUSION: This study demonstrated that treatment with montelukast in combination with levocetirizine may have a beneficial effect on clinical improvement of middle ear fluid in children with otitis media with effusion (OME). OBJECTIVE: To evaluate the effect of the combination of montelukast and levocetirizine on shortening the duration of effusion in successfully treated OME in children. METHODS: This was a randomized, prospective, double-blind, placebo-controlled trial...
December 2013: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/23905284/optimising-treatment-of-allergic-rhinitis-in-children
#17
REVIEW
Tom Marrs, Katherine Anagnostou, Roisin Fitzsimons, Adam T Fox
Acute and chronic symptoms of allergic rhinitis (AR) can disrupt school and leisure activities, significantly reducing quality of life. Symptoms often impair sleep, resulting in tiredness and poor concentration. Children with seasonal AR perform significantly worse in summer exams, relative to their mock exam results, when compared with their peers. Those individuals showing most symptoms are also likely to be affected by other allergic diseases, magnifying the detrimental impact on quality of life. Nasal blockage is the most common complaint associated with chronic AR, with acute exacerbations causing sneezing, clear nasal discharge and itchy eyes following exposure to the relevant airborne triggers...
June 2013: Practitioner
https://www.readbyqxmd.com/read/22513081/a-trial-of-adding-lactobacillus-johnsonii-em1-to-levocetirizine-for-treatment-of-perennial-allergic-rhinitis-in-children-aged-7-12-years
#18
RANDOMIZED CONTROLLED TRIAL
Ko-Haung Lue, Hai-Lun Sun, Ko-Hsiu Lu, Min-Sho Ku, Ji-Nan Sheu, Ching-Hui Chan, Yun-Hu Wang
BACKGROUND: Supplementary consumption of probiotics may temporarily alter the intestinal microflora of infants and children, thereby preventing and treating allergic disorders. OBJECTIVE: To compare the clinical efficacy of levocetirizine with that of levocetirizine plus Lactobacillus johnsonii EM1 (Lj EM1) for treating perennial allergic rhinitis (PAR) in children. METHODS: Sixty-three children aged 7-12 years fulfilled the entry criteria for the study and had moderate to severe PAR of at least 1 year's duration...
July 2012: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/22149770/establishing-the-place-in-therapy-of-bilastine-in-the-treatment-of-allergic-rhinitis-according-to-aria-evidence-review
#19
REVIEW
Jean Bousquet, Ignacio Ansótegui, G Walter Canonica, Torsten Zuberbier, Carlos E Baena-Cagnani, Claus Bachert, Alvaro A Cruz, Sandra N González, Piotr Kuna, Mario Morais-Almeida, Joaquim Mullol, Dermot P Ryan, Mario Sánchez-Borges, Román Valiente, Martin K Church
BACKGROUND: The ARIA (Allergic Rhinitis and its Impact on Asthma) guidelines development group examined the properties of oral H(1)-antihistamines and made proposals about an 'optimal' drug. Several criteria should be met by oral H(1)-antihistamines in terms of their pharmacological, and clinical efficacy and safety profiles. OBJECTIVE: Bilastine, a new H(1)-antihistamine, has been approved in 28 European countries for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria in adults and children older than 12 years...
January 2012: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/21573249/bilastine-for-the-relief-of-allergy-symptoms
#20
REVIEW
B Sádaba Díaz de Rada, J R Azanza Perea, A Gomez-Guiu Hormigos
Bilastine is a potent inhibitor of the histamine H1 receptor. It was recently approved in 28 countries of the European Union for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria in adults and children older than 12 years. Data from preclinical studies confirmed its selectivity for the histamine H1 receptor over other receptors, and demonstrated antihistaminic and antiallergic properties in vivo. Studies in healthy volunteers and patients have shown that bilastine does not affect driving ability, cardiac conduction or alertness...
April 2011: Drugs of Today
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