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https://www.readbyqxmd.com/read/28345681/-studies-on-lyme-disease-incidence-rates-in-selected-groups-of-forestry-workers-in-west-pomerania-2005-2014
#1
Tomasz Stawicki
BACKGROUND: The data collected by sanitary-epidemiological stations in 2005-2014 were analyzed to determine the incidence rates of borreliosis Lyme disease in the West Pomerania group of workers exposed to tick bites. MATERIAL AND METHODS: It was assumed that an adequate comparison of official epidemiological data with the data concerning the number of exposed people, is an indispensable condition for assessing properly the trend in Lyme disease incidence rates, concerning at the same time a real scale of occupational exposure...
March 24, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28344849/developing-asbestos-job-exposure-matrix-using-occupation-and-industry-specific-exposure-data-1984-2008-in-republic-of-korea
#2
Sangjun Choi, Dongmug Kang, Donguk Park, Hyunhee Lee, Bongkyoo Choi
BACKGROUND: The goal of this study is to develop a general population job-exposure matrix (GPJEM) on asbestos to estimate occupational asbestos exposure levels in the Republic of Korea. METHODS: Three Korean domestic quantitative exposure datasets collected from 1984 to 2008 were used to build the GPJEM. Exposure groups in collected data were reclassified based on the current Korean Standard Industrial Classification (9(th) edition) and the Korean Standard Classification of Occupations code (6(th) edition) that is in accordance to international standards...
March 2017: Safety and Health At Work
https://www.readbyqxmd.com/read/28344095/early-detection-clinical-diagnosis-and-management-of-lung-disease-from-exposure-to-diacetyl
#3
Cecile S Rose
Inhalation of diacetyl-containing products is associated with risk for occupational bronchiolitis obliterans (BO) and fixed airways obstruction, particularly in workers exposed to heated liquids and powdered formulations. This review describes the occupational settings in which diacetyl-related lung disease has been reported and the clinical presentation of disease, along with an approach to diagnosis and management. The importance of early disease recognition, appropriate removal from exposure, and medical monitoring to optimize prognosis is reviewed...
March 23, 2017: Toxicology
https://www.readbyqxmd.com/read/28341862/follistatin-like-1-aggravates-silica-induced-mouse-lung-injury
#4
Yinshan Fang, Si Zhang, Xiaohe Li, Fangxin Jiang, Qiao Ye, Wen Ning
Occupational inhalation of dust, such as crystalline silica, for prolonged periods in the workplace leads to fibrotic lung diseases worldwide. The mechanisms underlying the diseases are unknown, so that no effective treatment exists for these conditions. We found elevated levels of follistatin like 1 (FSTL1) in serum from patients with silicosis and in lungs from silica-induced mouse model. The induced Fstl1 regulated inflammation response via activation of nod-like receptor family, pyrin domain containing 3v (NLRP3) inflammasome-mediated IL-1β production from macrophages...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28341600/metabolic-disorder-dysfunction-in-parkinson-s-disease-bioenergetics-redox-homeostasis-and-central-carbon-metabolism
#5
Annadurai Anandhan, Maria S Jacome, Shulei Lei, Pablo Hernandez-Franco, Aglaia Pappa, Mihalis I Panayiotidis, Robert Powers, Rodrigo Franco
The loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the accumulation of protein inclusions (Lewy bodies) are the pathological hallmarks of Parkinson's disease (PD). PD is triggered by genetic alterations, environmental/occupational exposures and aging. However, the exact molecular mechanisms linking these PD risk factors to neuronal dysfunction are still unclear. Alterations in redox homeostasis and bioenergetics (energy failure) are thought to be central components of neurodegeneration that contribute to the impairment of important homeostatic process in dopaminergic cells such as protein quality control mechanisms, neurotransmitter release/metabolism, axonal transport of vesicles and cell survival...
March 21, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28339739/unabated-occupational-risk-in-a-patient-with-rheumatoid-pulmonary-fibrosis
#6
V K Holden, S J Kligerman, T G Hastings, S E Hines
Background: This case highlights the importance of considering hypersensitivity pneumonitis (HP) in the differential diagnosis of interstitial lung disease (ILD) and of obtaining an occupational history so that remediable risk factors may be identified and managed. Aims: To report a case of a chicken sexer with severe rheumatoid arthritis (RA) who developed progressively worsening dyspnoea and restrictive lung disease associated with pulmonary fibrosis. Methods: Clinical investigation included physical examination, occupational history, pulmonary function tests (PFTs), chest imaging and bronchoalveolar lavage (BAL), as well as serological tests including standard IgE bird feather mixture and local IgG precipitin preparation to chicken excrement...
February 23, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/28339055/new-insights-on-old-toxicants-in-occupational-toxicology-review
#7
Chiara Costa, Edoardo Miozzi, Michele Teodoro, Giusi Briguglio, Venerando Rapisarda, Concettina Fenga
In order to deliver the best possible working environment, it is essential to identify professional conditions that could be harmful for worker's health and prevent (or limit) the occurrence of such conditions. The appropriate use of personal protective equipment and the development of appropriate regulations allowed to reduce the prevalence of 'classic' occupational diseases, such as occupational hearing loss or asbestosis, just to name a few. Nowadays, environmental pollution seems to be one of the most relevant concerns for human and animal health, and toxicology is becoming one of the most prominent fields of interest in occupational settings...
March 24, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28339013/immunological-effects-of-occupational-exposure-to-lead-review
#8
Concettina Fenga, Silvia Gangemi, Valentina Di Salvatore, Luca Falzone, Massimo Libra
It is well-known that occupational and environmental exposure to several factors, including benzene, heavy metals, chemicals and mineral fibers, is associated with the risk of developing a great number of diseases. Numerous studies have been carried out in order to investigate the mechanisms of toxicity of these substances, with particular regard to the possible toxic effects on the immune system. However, little is known about the influence of heavy metals, such as lead, on the immune system in human populations...
March 24, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28337648/diagnosis-and-treatment-of-alternating-hemiplegia-of-childhood
#9
REVIEW
Melanie Masoud, Lyndsey Prange, Jeffrey Wuchich, Arsen Hunanyan, Mohamad A Mikati
The diagnosis and treatment of patients with Alternating Hemiplegia of Childhood (AHC) and related disorders should be provided by a multidisciplinary team experienced with the spectrum of presentations of this disease, with its related disorders, with its complex and fluctuating manifestations, and with cutting edge advances occurring in the field. Involvement in research to advance the understanding of this disease and partnership with international collaborators and family organizations are also important...
February 2017: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/28337093/assessment-of-socioeconomic-status-and-control-of-asthma-in-adults
#10
I A Azeez, M M A Ladipo, O M Ige
BACKGROUND: Asthma is a chronic disease which places considerable economic, social and public health burdens on the society. Education, occupation and income are the most widely used indicators of socioeconomic status (SES). Studies have shown increased asthma hospital admissions for those who are materially deprived and increased asthma severity in low social class groups. The aim of this study is to determine the impact of socioeconomic status on control of asthma in adults. METHOD: The study was a cross-sectional analytical one, conducted over a year at the Medical Outpatient Clinic of the University College Hospital Ibadan...
December 2016: Annals of Ibadan Postgraduate Medicine
https://www.readbyqxmd.com/read/28336154/socioeconomic-and-therapy-factor-influence-on-self-reported-fatigue-anxiety-and-depression-in-rheumatoid-arthritis-patients
#11
Mirjana Lapčević, Mira Vuković, Branislav S Gvozdenović, Vesna Mioljević, Snežana Marjanović
INTRODUCTION: Fatigue, anxiety and depression are very frequent symptoms in patients with rheumatoid arthritis (RA). GOALS: In this study we evaluated the influence of socioeconomic characteristics, therapy and comorbidities on the self-reported high fatigue, anxiety and depression in patients with RA. METHOD: Multicenter cross-sectional study was performed in 22 health institutions in Serbia during the period from April-August 2014 in population of older RA patients...
February 27, 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28335768/leisure-sedentary-time-is-differentially-associated-with-hypertension-diabetes-mellitus-and-hyperlipidemia-depending-on-occupation
#12
Man Sup Lim, Bumjung Park, Il Gyu Kong, Songyong Sim, So Young Kim, Jin-Hwan Kim, Hyo Geun Choi
BACKGROUND: Sedentary behavior is considered an independent cause of cardio-metabolic diseases, regardless of physical activity level and obesity. Few studies have reported the association between leisure sedentary time and cardio-vascular diseases in terms of occupation. METHODS: We performed a cross-sectional study using data from the Korean Community Health Survey (KCHS) for 240,086 participants assessed in 2011 and 2013. Occupation was categorized into four groups: farmer or fisherman, laborer, and soldier (Group I); service worker, salesperson, technician, mechanic, production worker, and engineer (Group II); manager, expert, specialist, and clerk (Group III); and unemployed (Group IV)...
March 23, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28334978/therapeutic-window-of-dopamine-d2-3-receptor-occupancy-to-treat-psychosis-in-alzheimer-s-disease
#13
Suzanne Reeves, Emma McLachlan, Julie Bertrand, Fabrizia D Antonio, Stuart Brownings, Akshay Nair, Suki Greaves, Alan Smith, David Taylor, Joel Dunn, Paul Marsden, Robert Kessler, Robert Howard
Antipsychotic drugs, originally developed to treat schizophrenia, are used to treat psychosis, agitation and aggression in Alzheimer's disease. In the absence of dopamine D2/3 receptor occupancy data to inform antipsychotic prescribing for psychosis in Alzheimer's disease, the mechanisms underpinning antipsychotic efficacy and side effects are poorly understood. This study used a population approach to investigate the relationship between amisulpride blood concentration and central D2/3 occupancy in older people with Alzheimer's disease by combining: (i) pharmacokinetic data (280 venous samples) from a phase I single (50 mg) dose study in healthy older people (n = 20, 65-79 years); (ii) pharmacokinetic, 18F-fallypride D2/3 receptor imaging and clinical outcome data on patients with Alzheimer's disease who were prescribed amisulpride (25-75 mg daily) to treat psychosis as part of an open study (n = 28; 69-92 years; 41 blood samples, five pretreatment scans, 19 post-treatment scans); and (iii) 18F-fallypride imaging of an antipsychotic free Alzheimer's disease control group (n = 10, 78-92 years), to provide additional pretreatment data...
February 4, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28332953/patterns-of-response-by-sociodemographic-characteristics-and-recruitment-methods-for-women-in-uk-population-surveys-and-cohort-studies
#14
Sarah J Howcutt, Anna L Barnett, Sofia Barbosa Boucas, Lesley A Smith
Women are an important public health focus, because they are more likely to experience some social determinants of disease, and they influence family health. Little research has explored the sociodemographic representativeness of women in research studies. We examined the representativeness of female respondents across four sociodemographic factors in UK population surveys and cohort studies. Six UK population-based health surveys (from 2009-2013) and eight Medical Research Council cohort studies (from 1991 to 2014) were included...
March 23, 2017: Women & Health
https://www.readbyqxmd.com/read/28332072/are-the-autoimmune-inflammatory-syndrome-induced-by-adjuvants-asia-and-the-undifferentiated-connective-tissue-disease-uctd-related-to-each-other-a-case-control-study-of-environmental-exposures
#15
F Scanzi, L Andreoli, M Martinelli, M Taraborelli, I Cavazzana, N Carabellese, R Ottaviani, F Allegri, F Franceschini, N Agmon-Levin, Y Shoenfeld, Angela Tincani
The autoimmune/inflammatory syndrome induced by adjuvants (ASIA) is an entity that includes different autoimmune conditions observed after exposure to an adjuvant. Patients with undifferentiated connective tissue disease (UCTD) present many signs and symptoms of ASIA, alluding to the idea that an exposure to adjuvants can be a trigger also for UCTD. The aim of this case-control study was to investigate exposure to adjuvants prior to disease onset in patients affected by UCTD. Ninety-two UCTD patients and 92 age- and sex-matched controls with no malignancy, chronic infections, autoimmune disease nor family history of autoimmune diseases were investigated for exposure to adjuvants...
March 22, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28331627/topical-drug-induced-subacute-cutaneous-lupus-erythematosus-isolated-to-the-hands
#16
Sarika M Ramachandran, Jonathan S Leventhal, Loren G Franco, Adnan Mir, Ruth F Walters, Andrew G Franks
Subacute cutaneous lupus erythematosus (SCLE) is a well-defined subtype of lupus erythematosus, characterised by photosensitivity, annular and/or psoriasiform lesions, variable systemic involvement and presence of circulating SSA/anti-Ro antibodies. SCLE may be idiopathic or drug-induced. Both the idiopathic and drug-induced forms of SCLE are analogous in their clinical, serological and histological features. Drug-induced SCLE has been reported with various oral agents, but to our knowledge this is the first reported case due to a topical medication...
2017: Lupus Science & Medicine
https://www.readbyqxmd.com/read/28328293/history-of-knowledge-and-evolution-of-occupational-health-and-regulatory-aspects-of-asbestos-exposure-science-1900-1975
#17
Christy A Barlow, Jennifer Sahmel, Dennis J Paustenbach, John L Henshaw
The understanding by industrial hygienists of the hazards of asbestos and appropriate ways to characterize and control exposure has evolved over the years. Here, a detailed analysis of the evolution of industrial hygiene practices regarding asbestos and its health risks, from the early 1900s until the advent of the national occupational health and safety regulatory structure currently in place in the US (early-to-mid 1970s) is presented. While industrial hygienists recognized in the early 1900s that chronic and high-level exposures to airborne concentrations of asbestos could pose a serious health hazard, it was not until the mid-1950s that the carcinogenic nature of asbestos began to be characterized and widespread concern followed...
March 22, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28327796/keeping-track-of-hidden-dangers-the-short-history-of-the-sabi%C3%A3-virus
#18
Joel Henrique Ellwanger, José Artur Bogo Chies
Emerging infectious diseases are a global threat. In countries like Brazil, where biodiversity is high and public health conditions in terms of infrastructure and medical care are often precarious, emerging diseases are particularly worrisome. The lack of monitoring strategies to identify pathogens with the potential to cause outbreaks or epidemics is another problem in Brazil and other developing countries. In this article, we present the history of the Sabiá virus (SABV), a pathogen that was described in the 1990s in Brazil...
January 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28327542/occupational-respiratory-diseases-of-miners-from-two-gold-mines-in-ghana
#19
Esther Ayaaba, Yan Li, Jiali Yuan, Chunhui Ni
n/a.
March 22, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28326180/are-physicians-in-primary-health-care-able-to-recognize-pulmonary-fibrosis
#20
Minna Purokivi, Ulla Hodgson, Marjukka Myllärniemi, Eija-Riitta Salomaa, Riitta Kaarteenaho
Background: The early diagnosis of idiopathic pulmonary fibrosis (IPF) has become increasingly important due to evolving treatment options. IPF patients experience a significant delay in receiving an accurate diagnosis, thus delayed access to tertiary care is associated with higher mortality independently from disease severity. Objective: The aims were to evaluate whether there had been a delay in the referral process, and to determine whether the referring doctors had suspected IPF or other interstitial lung disease (ILD) already during the time of referral...
2017: European Clinical Respiratory Journal
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