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https://www.readbyqxmd.com/read/29399826/photodynamic-therapy-via-navigational-bronchoscopy-for-peripheral-lung-cancer-in-dogs
#1
Ali I Musani, Julia K Veir, Zheng Huang, Tim Lei, Steve Groshong, Deanna Worley
OBJECTIVE: In the setting of lung cancer, photodynamic therapy (PDT) is typically used to treat centrally located endobronchial tumors. The development of navigational bronchoscopy has opened the potential for using PDT to treat peripheral lung tumors. However, there is limited information about the feasibility of this approach for treating peripheral lung cancers, and about its effects on surrounding healthy lung tissue. We studied the use of PDT delivered by electromagnetic navigational bronchoscopy to treat peripheral lung cancer in dogs...
February 5, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29329326/utilization-of-peptide-phage-display-to-investigate-hotspots-on-il-17a-and-what-it-means-for-drug-discovery
#2
Joey P Ting, Frances Tung, Stephen Antonysamy, Stephen Wasserman, Spencer B Jones, Feiyu F Zhang, Alfonso Espada, Howard Broughton, Michael J Chalmers, Michael E Woodman, Holly A Bina, Jeffrey A Dodge, Jordi Benach, Aiping Zhang, Christopher Groshong, Danalyn Manglicmot, Marijane Russell, Sepideh Afshar
To date, IL-17A antibodies remain the only therapeutic approach to correct the abnormal activation of the IL-17A/IL-17R signaling complex. Why is it that despite the remarkable success of IL-17 antibodies, there is no small molecule antagonist of IL-17A in the clinic? Here we offer a unique approach to address this question. In order to understand the interaction of IL-17A with its receptor, we combined peptide discovery using phage display with HDX, crystallography, and functional assays to map and characterize hot regions that contribute to most of the energetics of the IL-17A/IL-17R interaction...
2018: PloS One
https://www.readbyqxmd.com/read/29259089/peptide-uptake-is-essential-for-borrelia-burgdorferi-viability-and-involves-structural-and-regulatory-complexity-of-its-oligopeptide-transporter
#3
Ashley M Groshong, Abhishek Dey, Irina Bezsonova, Melissa J Caimano, Justin D Radolf
Borrelia burgdorferi is an extreme amino acid (AA) auxotroph whose genome encodes few free AA transporters and an elaborate oligopeptide transport system (B. burgdorferi Opp [BbOpp]). BbOpp consists of five oligopeptide-binding proteins (OBPs), two heterodimeric permeases, and a heterodimeric nucleotide-binding domain (NBD). Homology modeling based on the crystal structure of liganded BbOppA4 revealed that each OBP likely binds a distinct range of peptides. Transcriptional analyses demonstrated that the OBPs are differentially and independently regulated whereas the permeases and NBDs are constitutively expressed...
December 19, 2017: MBio
https://www.readbyqxmd.com/read/29143645/impact-of-heat-treatment-on-dirofilaria-immitis-antigen-detection-in-shelter-dogs
#4
Brian A DiGangi, Carly Dworkin, Jason W Stull, Jeanette O'Quin, Morgan Elser, Antoinette E Marsh, Lesli Groshong, Wendy Wolfson, Brandy Duhon, Katie Broaddus, Elise N Gingrich, Emily Swiniarski, Elizabeth A Berliner
BACKGROUND: The diagnosis and management of canine heartworm disease is a growing concern for shelter veterinarians. Although the accuracy of commercial antigen test kits has been widely studied, recent reports have renewed interest in antigen blocking as a causative factor for false "no antigen detected" results. The objectives of this study were to determine the prevalence of false "no antigen detected" results in adult dogs entering shelters in northern, southern, and western regions of the country and to identify historical and clinical risk factors for such results...
November 9, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29058451/reply-improving-care-for-patients-with-interstitial-lung-disease-using-machine-learning-requires-transparency-and-reproducibility
#5
Giulia C Kennedy, Neil M Barth, P Sean Walsh, Jing Huang, Daniel G Pankratz, Yoonha Choi, Grażyna M Fedorowicz, Jessica D Anderson, Ganesh Raghu, Fernando J Martinez, Thomas V Colby, David A Lynch, Kevin K Brown, Steve D Groshong, Jeffrey L Myers, Kevin R Flaherty, Mark P Steele
NA.
October 23, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28919186/nonsurgical-treatment-of-delayed-onset-brachial-plexopathy-due%C3%A2-to-hypertrophic-clavicular-callus-a-case-report
#6
REVIEW
Benjamin M Carpenter, David R Pettersson, Adam J Mirarchi, Drew Groshong, Hans L Carlson
Clavicular fractures are common injuries that traditionally are managed nonsurgically without clinically significant sequelae. However, they may develop hypertrophic callus formation that compresses the brachial plexus. These cases may present months to years after initial injury with varying degrees of pain, paresthesia, and weakness on the affected side and usually are treated by surgical resection of the hypertrophic callus. We present a case of brachial plexopathy due to hypertrophic clavicular callus causing weakness and paresthesia...
September 12, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28640655/usual-interstitial-pneumonia-can-be-detected-in-transbronchial-biopsies-using-machine-learning
#7
Daniel G Pankratz, Yoonha Choi, Urooj Imtiaz, Grażyna M Fedorowicz, Jessica D Anderson, Thomas V Colby, Jeffrey L Myers, David A Lynch, Kevin K Brown, Kevin R Flaherty, Mark P Steele, Steve D Groshong, Ganesh Raghu, Neil M Barth, P Sean Walsh, Jing Huang, Giulia C Kennedy, Fernando J Martinez
RATIONALE: Usual interstitial pneumonia (UIP) is the histopathologic hallmark of idiopathic pulmonary fibrosis. Although UIP can be detected by high-resolution computed tomography of the chest, the results are frequently inconclusive, and pathology from transbronchial biopsy (TBB) has poor sensitivity. Surgical lung biopsy may be necessary for a definitive diagnosis. OBJECTIVES: To develop a genomic classifier in tissue obtained by TBB that distinguishes UIP from non-UIP, trained against central pathology as the reference standard...
November 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28202859/experience-of-peripherally-inserted-central-venous-catheter-in-patients-with-hematologic-diseases
#8
Yoshinori Hashimoto, Takanori Fukuta, Junko Maruyama, Hiromi Omura, Takayuki Tanaka
Objective Although use of the peripherally inserted central venous catheter (PICC) has become increasingly common, there are few reports of PICCs used for patients with hematologic diseases. In this study, we analyzed the safety of PICC placement in patients with hematologic diseases where PICCs had been placed to perform blood collection, blood transfusion, drug administration, and hematopoietic stem cell transplantation. Methods This study included 142 PICCs placed in 95 patients managed at our department from November 2013 to December 2015...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28002967/discovery-of-1s-2r-3s-4s-5r-6r-2-amino-3-3-4-difluorophenyl-sulfanylmethyl-4-hydroxy-bicyclo-3-1-0-hexane-2-6-dicarboxylic-acid-hydrochloride-ly3020371%C3%A2-hcl-a-potent-metabotropic-glutamate-2-3-receptor-antagonist-with-antidepressant-like-activity
#9
Mark D Chappell, Renhua Li, Stephon C Smith, Bruce A Dressman, Eric G Tromiczak, Allie E Tripp, Maria-Jesus Blanco, Tatiana Vetman, Steven J Quimby, James Matt, Thomas C Britton, Adam M Fivush, Jeffrey M Schkeryantz, Daniel Mayhugh, Jon A Erickson, Mark G Bures, Carlos Jaramillo, Mercedes Carpintero, José Eugenio de Diego, Mario Barberis, Susana Garcia-Cerrada, José F Soriano, Stephen Antonysamy, Shane Atwell, Iain MacEwan, Bradley Condon, Christine Sougias, Jing Wang, Aiping Zhang, Kris Conners, Chris Groshong, Stephen R Wasserman, John W Koss, Jeffrey M Witkin, Xia Li, Carl Overshiner, Keith A Wafford, Wesley Seidel, Xu-Shan Wang, Beverly A Heinz, Steven Swanson, John T Catlow, David W Bedwell, James A Monn, Charles H Mitch, Paul L Ornstein
As part of our ongoing efforts to identify novel ligands for the metabotropic glutamate 2 and 3 (mGlu2/3) receptors, we have incorporated substitution at the C3 and C4 positions of the (1S,2R,5R,6R)-2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid scaffold to generate mGlu2/3 antagonists. Exploration of this structure-activity relationship (SAR) led to the identification of (1S,2R,3S,4S,5R,6R)-2-amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid hydrochloride (LY3020371·HCl, 19f), a potent, selective, and maximally efficacious mGlu2/3 antagonist...
December 22, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27775472/exploring-attitudes-perceived-norms-and-personal-agency-insights-into-theory-based-messages-to-encourage-park-based-physical-activity-in-low-income-urban-neighborhoods
#10
Lisa Groshong, Sonja A Wilhelm Stanis, Andrew T Kaczynski, J Aaron Hipp, Gina M Besenyi
BACKGROUND: Public parks hold promise for promoting population-level PA, but studies show a significant portion of park use is sedentary. Past research has documented the effectiveness of message-based strategies for influencing diverse behaviors in park settings and for increasing PA in nonpark contexts. Therefore, to inform message-based interventions (eg, point-ofdecision prompts) to increase park-based PA, the purpose of this study was to elicit insights about key attitudes, perceived norms, and personal agency that affect park use and park-based PA in low-income urban neighborhoods...
February 2017: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/27768210/fracture-of-totally-implanted-central-venous-access-devices-a-propensity-score-matched-comparison-of-risks-for-groshong-silicone-versus-polyurethane-catheters
#11
COMPARATIVE STUDY
Soichi Kojima, Takao Hiraki, Hideo Gobara, Toshihiro Iguchi, Hiroyasu Fujiwara, Yusuke Matsui, Toshiharu Mitsuhashi, Susumu Kanazawa
PURPOSE: To evaluate retrospectively the fracture risk of totally implanted venous access devices connected to Groshong silicone (SC) versus polyurethane (PU) catheters, inserted via the internal jugular vein. MATERIALS AND METHODS: The study population comprised 384 SC and 221 PU central venous catheters implanted via the internal jugular vein. The presence of catheter fracture was evaluated. Variables possibly related to catheter fracture were evaluated. First, in order to determine the factors associated with fracture, fracture rates were compared with the log-rank test between the two groups divided by each of the variables...
November 2, 2016: Journal of Vascular Access
https://www.readbyqxmd.com/read/27702673/mechanism-of-th2-th17-predominant-and-neutrophilic-th2-th17-low-subtypes-of-asthma
#12
Weimin Liu, Sucai Liu, Mukesh Verma, Iram Zafar, James T Good, Donald Rollins, Stephen Groshong, Magdalena M Gorska, Richard J Martin, Rafeul Alam
BACKGROUND: The mechanism of TH2/TH17-predominant and TH2/TH17-low asthma is unknown. OBJECTIVE: We sought to study the immune mechanism of TH2/TH17-predominant and TH2/TH17-low asthma. METHODS: In a previously reported cohort of 60 asthmatic patients, 16 patients were immunophenotyped with TH2/TH17-predominant asthma and 22 patients with TH2/TH17-low asthma. We examined bronchoalveolar lavage (BAL) fluid leukocytes, cytokines, mediators, and epithelial cell function for these asthma subgroups...
May 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27650251/cycle-training-modulates-satellite-cell-and-transcriptional-responses-to-a-bout-of-resistance-exercise
#13
Kevin A Murach, R Grace Walton, Christopher S Fry, Sami L Michaelis, Jason S Groshong, Brian S Finlin, Philip A Kern, Charlotte A Peterson
This investigation evaluated whether moderate-intensity cycle ergometer training affects satellite cell and molecular responses to acute maximal concentric/eccentric resistance exercise in middle-aged women. Baseline and 72 h postresistance exercise vastus lateralis biopsies were obtained from seven healthy middle-aged women (56 ± 5 years, BMI 26 ± 1, VO2max 27 ± 4) before and after 12 weeks of cycle training. Myosin heavy chain (MyHC) I- and II-associated satellite cell density and cross-sectional area was determined via immunohistochemistry...
September 2016: Physiological Reports
https://www.readbyqxmd.com/read/27438669/what-nurses-need-to-know-about-pku
#14
Janice Sampson, Megan Groshong, Denise M Wall Parilo
No abstract text is available yet for this article.
August 2016: Nursing
https://www.readbyqxmd.com/read/27266705/genome-wide-imputation-study-identifies-novel-hla-locus-for-pulmonary-fibrosis-and-potential-role-for-auto-immunity-in-fibrotic-idiopathic-interstitial-pneumonia
#15
Tasha E Fingerlin, Weiming Zhang, Ivana V Yang, Hannah C Ainsworth, Pamela H Russell, Rachel Z Blumhagen, Marvin I Schwarz, Kevin K Brown, Mark P Steele, James E Loyd, Gregory P Cosgrove, David A Lynch, Steve Groshong, Harold R Collard, Paul J Wolters, Williamson Z Bradford, Karl Kossen, Scott D Seiwert, Roland M du Bois, Christine Kim Garcia, Megan S Devine, Gunnar Gudmundsson, Helgi J Isaksson, Naftali Kaminski, Yingze Zhang, Kevin F Gibson, Lisa H Lancaster, Toby M Maher, Philip L Molyneaux, Athol U Wells, Miriam F Moffatt, Moises Selman, Annie Pardo, Dong Soon Kim, James D Crapo, Barry J Make, Elizabeth A Regan, Dinesha S Walek, Jerry J Daniel, Yoichiro Kamatani, Diana Zelenika, Elissa Murphy, Keith Smith, David McKean, Brent S Pedersen, Janet Talbert, Julia Powers, Cheryl R Markin, Kenneth B Beckman, Mark Lathrop, Brian Freed, Carl D Langefeld, David A Schwartz
BACKGROUND: Fibrotic idiopathic interstitial pneumonias (fIIP) are a group of fatal lung diseases with largely unknown etiology and without definitive treatment other than lung transplant to prolong life. There is strong evidence for the importance of both rare and common genetic risk alleles in familial and sporadic disease. We have previously used genome-wide single nucleotide polymorphism data to identify 10 risk loci for fIIP. Here we extend that work to imputed genome-wide genotypes and conduct new RNA sequencing studies of lung tissue to identify and characterize new fIIP risk loci...
June 7, 2016: BMC Genetics
https://www.readbyqxmd.com/read/26821435/your-missouri-delegation-continues-in-leadership-roles-at-the-ama-meeting
#16
Ted Groshong
No abstract text is available yet for this article.
November 2015: Missouri Medicine
https://www.readbyqxmd.com/read/26816406/damage-of-central-catheters-in-home-parenteral-nutrition-patients
#17
COMPARATIVE STUDY
Renata Błasiak, Michał Ławiński, Krystyna Majewska, Aleksandra Gradowska
UNLABELLED: According to the ESPEN and ASPEN guidelines, in the case of a long-term (>3-month) parenteral nutrition should be administered via a subcutaneous central venous catheter (CVC). There are three types of mechanical complications of tunnelled central catheter: catheter rupture, occlusion by TPN depositing and thrombofibrotic occlusion. The aim of the study was to analyse the incidence of complications central catheter in a group of patients receiving HPN. MATERIAL AND METHODS: Between January 2010 and June 2014, HPN was conducted in 584 patients (306 women and 278 men), ninety-nine patients were enrolled in the study: 67 women and 32 men in whom mechanical complications of central catheters were found...
November 2015: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/26653180/discovery-and-characterization-of-2-acylaminoimidazole-microsomal-prostaglandin-e-synthase-1-inhibitors
#18
Matthew A Schiffler, Stephen Antonysamy, Shobha N Bhattachar, Kristina M Campanale, Srinivasan Chandrasekhar, Bradley Condon, Prashant V Desai, Matthew J Fisher, Christopher Groshong, Anita Harvey, Michael J Hickey, Norman E Hughes, Scott A Jones, Euibong J Kim, Steven L Kuklish, John G Luz, Bryan H Norman, Richard E Rathmell, John R Rizzo, Thomas W Seng, Stefan J Thibodeaux, Timothy A Woods, Jeremy S York, Xiao-Peng Yu
As part of a program aimed at the discovery of antinociceptive therapy for inflammatory conditions, a screening hit was found to inhibit microsomal prostaglandin E synthase-1 (mPGES-1) with an IC50 of 17.4 μM. Structural information was used to improve enzyme potency by over 1000-fold. Addition of an appropriate substituent alleviated time-dependent cytochrome P450 3A4 (CYP3A4) inhibition. Further structure-activity relationship (SAR) studies led to 8, which had desirable potency (IC50 = 12 nM in an ex vivo human whole blood (HWB) assay) and absorption, distribution, metabolism, and excretion (ADME) properties...
January 14, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/26606811/missouri-physicians-share-medical-expertise-with-the-country-of-georgia-through-a-call-to-serve-international-acts-i
#19
Milamari A Cunningham, Elizabeth James, Ted Groshong, Patricia J Blair, Giorgi Tsilosani
No abstract text is available yet for this article.
September 2015: Missouri Medicine
https://www.readbyqxmd.com/read/26150534/bb0744-affects-tissue-tropism-and-spatial-distribution-of-borrelia-burgdorferi
#20
Beau Wager, Dana K Shaw, Ashley M Groshong, Jon S Blevins, Jon T Skare
Borrelia burgdorferi, the etiologic agent of Lyme disease, produces a variety of proteins that promote survival and colonization in both the Ixodes species vector and various mammalian hosts. We initially identified BB0744 (also known as p83/100) by screening for B. burgdorferi strain B31 proteins that bind to α1β1 integrin and hypothesized that, given the presence of a signal peptide, BB0744 may be a surface-exposed protein. In contrast to this expectation, localization studies suggested that BB0744 resides in the periplasm...
September 2015: Infection and Immunity
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