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https://www.readbyqxmd.com/read/29727583/protein-tyrosine-phosphatase-n13-ptpn13-promotes-myofibroblast-resistance-to-apoptosis-in-idiopathic-pulmonary-fibrosis
#1
Alison Bamberg, Elizabeth F Redente, Steve D Groshong, Rubin M Tuder, Carlyne D Cool, Rebecca C Keith, Benjamin L Edelman, Bart P Black, Gregory P Cosgrove, Murry W Wynes, Douglas Curran-Everett, Stijn De Langhe, Luis A Ortiz, Andrew Thorburn, David W H Riches
RATIONALE: Idiopathic pulmonary fibrosis (IPF) is a progressive, fibrotic interstitial lung disease characterized by (myo)fibroblast accumulation and collagen deposition. Resistance to Fas-induced apoptosis is thought to facilitate (myo)fibroblast persistence in fibrotic lung tissues, by poorly understood mechanisms. OBJECTIVES: We tested the hypothesis that protein tyrosine phosphatase PTPN13 is expressed by IPF lung (myo)fibroblasts, promotes their resistance to Fas-induced apoptosis and contributes to the development of pulmonary fibrosis...
May 4, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29701120/comparison-of-two-types-of-catheters-through-femoral-vein-catheterization-in-patients-with-lung-cancer-undergoing-chemotherapy-a-retrospective-study
#2
Binbin Xu, Jinghui Zhang, Siyuan Tang, Jianmei Hou, Mengdan Ma
PURPOSE: This study aimed to investigate the effects and complications of different types of peripherally inserted central catheters through femoral vein catheterization in patients with lung cancer undergoing chemotherapy. METHODS: A retrospective analysis of 158 patients with lung cancer undergoing implantation of a venous access through femoral vein catheterization was performed. The patients were divided into two groups by convenience sampling: the single-lumen silicone Groshong peripherally inserted central catheters with valved tip were used in patients in group A, the single-lumen power-injectable polyurethane peripherally inserted central catheters with no valve were used in patients in group B...
April 1, 2018: Journal of Vascular Access
https://www.readbyqxmd.com/read/29695780/structural-basis-for-gpr40-allosteric-agonism-and-incretin-stimulation
#3
Joseph D Ho, Betty Chau, Logan Rodgers, Frances Lu, Kelly L Wilbur, Keith A Otto, Yanyun Chen, Min Song, Jonathan P Riley, Hsiu-Chiung Yang, Nichole A Reynolds, Steven D Kahl, Anjana Patel Lewis, Christopher Groshong, Russell E Madsen, Kris Conners, Jayana P Lineswala, Tarun Gheyi, Melbert-Brian Decipulo Saflor, Matthew R Lee, Jordi Benach, Kenton A Baker, Chahrzad Montrose-Rafizadeh, Michael J Genin, Anne R Miller, Chafiq Hamdouchi
Activation of free fatty acid receptor 1 (GPR40) by synthetic partial and full agonists occur via distinct allosteric sites. A crystal structure of GPR40-TAK-875 complex revealed the allosteric site for the partial agonist. Here we report the 2.76-Å crystal structure of human GPR40 in complex with a synthetic full agonist, compound 1, bound to the second allosteric site. Unlike TAK-875, which acts as a Gαq -coupled partial agonist, compound 1 is a dual Gαq and Gαs -coupled full agonist. compound 1 binds in the lipid-rich region of the receptor near intracellular loop 2 (ICL2), in which the stabilization of ICL2 by the ligand is likely the primary mechanism for the enhanced G protein activities...
April 25, 2018: Nature Communications
https://www.readbyqxmd.com/read/29685079/method-to-characterize-inorganic-particulates-in-lung-tissue-biopsies-using-field-emission-scanning-electron-microscopy
#4
Heather A Lowers, G N Breit, M Strand, R M Pillers, G P Meeker, T I Todorov, G S Plumlee, R E Wolf, M Robinson, J Parr, R Miller, S Groshong, F Green, C Rose
Humans accumulate large numbers of inorganic particles in their lungs over a lifetime. Whether this causes or contributes to debilitating disease over a normal lifespan depends on the type and concentration of the particles. We developed and tested a protocol for in situ characterization of the types and distribution of inorganic particles in biopsied lung tissue from three human groups using field emission scanning electron microscopy (FE-SEM) combined with energy dispersive spectroscopy (EDS). Many distinct particle types were recognized among the 13 000 particles analyzed...
April 23, 2018: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/29565179/the-relationship-between-complement-c3-expression-and-the-muc5b-genotype-in-pulmonary-fibrosis
#5
Tsukasa Okamoto, Susan K Mathai, Corinne E Hennessy, Laura A Hancock, Avram D Walts, Adrianne L Stefanski, Kevin K Brown, David A Lynch, Gregory P Cosgrove, Steve D Groshong, Carlyne D Cool, Marvin I Schwarz, Nirmal K Banda, Joshua M Thurman, Ivana V Yang, Vernon Michael Holers, David A Schwartz
The common gain-of-function MUC5B promoter variant (rs35705950) is the strongest risk factor for the development of idiopathic pulmonary fibrosis (IPF). While the role of complement in IPF is controversial, both MUC5B and the complement system play a role in lung host defense. The aim of this study was to evaluate the relationship between C3 and MUC5B in patients with IPF and in bleomycin-induced lung injury in mice. To do this, we evaluated C3 gene expression in whole lung tissue from 300 subjects with IPF and 175 healthy controls...
March 22, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29399826/photodynamic-therapy-via-navigational-bronchoscopy-for-peripheral-lung-cancer-in-dogs
#6
Ali I Musani, Julia K Veir, Zheng Huang, Tim Lei, Steve Groshong, Deanna Worley
OBJECTIVE: In the setting of lung cancer, photodynamic therapy (PDT) is typically used to treat centrally located endobronchial tumors. The development of navigational bronchoscopy has opened the potential for using PDT to treat peripheral lung tumors. However, there is limited information about the feasibility of this approach for treating peripheral lung cancers, and about its effects on surrounding healthy lung tissue. We studied the use of PDT delivered by electromagnetic navigational bronchoscopy to treat peripheral lung cancer in dogs...
February 5, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29329326/utilization-of-peptide-phage-display-to-investigate-hotspots-on-il-17a-and-what-it-means-for-drug-discovery
#7
Joey P Ting, Frances Tung, Stephen Antonysamy, Stephen Wasserman, Spencer B Jones, Feiyu F Zhang, Alfonso Espada, Howard Broughton, Michael J Chalmers, Michael E Woodman, Holly A Bina, Jeffrey A Dodge, Jordi Benach, Aiping Zhang, Christopher Groshong, Danalyn Manglicmot, Marijane Russell, Sepideh Afshar
To date, IL-17A antibodies remain the only therapeutic approach to correct the abnormal activation of the IL-17A/IL-17R signaling complex. Why is it that despite the remarkable success of IL-17 antibodies, there is no small molecule antagonist of IL-17A in the clinic? Here we offer a unique approach to address this question. In order to understand the interaction of IL-17A with its receptor, we combined peptide discovery using phage display with HDX, crystallography, and functional assays to map and characterize hot regions that contribute to most of the energetics of the IL-17A/IL-17R interaction...
2018: PloS One
https://www.readbyqxmd.com/read/29259089/peptide-uptake-is-essential-for-borrelia-burgdorferi-viability-and-involves-structural-and-regulatory-complexity-of-its-oligopeptide-transporter
#8
Ashley M Groshong, Abhishek Dey, Irina Bezsonova, Melissa J Caimano, Justin D Radolf
Borrelia burgdorferi is an extreme amino acid (AA) auxotroph whose genome encodes few free AA transporters and an elaborate oligopeptide transport system ( B. burgdorferi Opp [ Bb Opp]). Bb Opp consists of five oligopeptide-binding proteins (OBPs), two heterodimeric permeases, and a heterodimeric nucleotide-binding domain (NBD). Homology modeling based on the crystal structure of liganded Bb OppA4 revealed that each OBP likely binds a distinct range of peptides. Transcriptional analyses demonstrated that the OBPs are differentially and independently regulated whereas the permeases and NBDs are constitutively expressed...
December 19, 2017: MBio
https://www.readbyqxmd.com/read/29143645/impact-of-heat-treatment-on-dirofilaria-immitis-antigen-detection-in-shelter-dogs
#9
Brian A DiGangi, Carly Dworkin, Jason W Stull, Jeanette O'Quin, Morgan Elser, Antoinette E Marsh, Lesli Groshong, Wendy Wolfson, Brandy Duhon, Katie Broaddus, Elise N Gingrich, Emily Swiniarski, Elizabeth A Berliner
BACKGROUND: The diagnosis and management of canine heartworm disease is a growing concern for shelter veterinarians. Although the accuracy of commercial antigen test kits has been widely studied, recent reports have renewed interest in antigen blocking as a causative factor for false "no antigen detected" results. The objectives of this study were to determine the prevalence of false "no antigen detected" results in adult dogs entering shelters in northern, southern, and western regions of the country and to identify historical and clinical risk factors for such results...
November 9, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29058451/reply-improving-care-for-patients-with-interstitial-lung-disease-using-machine-learning-requires-transparency-and-reproducibility
#10
Giulia C Kennedy, Neil M Barth, P Sean Walsh, Jing Huang, Daniel G Pankratz, Yoonha Choi, Grażyna M Fedorowicz, Jessica D Anderson, Ganesh Raghu, Fernando J Martinez, Thomas V Colby, David A Lynch, Kevin K Brown, Steve D Groshong, Jeffrey L Myers, Kevin R Flaherty, Mark P Steele
No abstract text is available yet for this article.
December 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28919186/nonsurgical-treatment-of-delayed-onset-brachial-plexopathy-due-to-hypertrophic-clavicular-callus-a-case-report
#11
REVIEW
Benjamin M Carpenter, David R Pettersson, Adam J Mirarchi, Drew Groshong, Hans L Carlson
Clavicular fractures are common injuries that traditionally are managed nonsurgically without clinically significant sequelae. However, they may develop hypertrophic callus formation that compresses the brachial plexus. These cases may present months to years after initial injury with varying degrees of pain, paresthesia, and weakness on the affected side and usually are treated by surgical resection of the hypertrophic callus. We present a case of brachial plexopathy due to hypertrophic clavicular callus causing weakness and paresthesia...
April 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28640655/usual-interstitial-pneumonia-can-be-detected-in-transbronchial-biopsies-using-machine-learning
#12
Daniel G Pankratz, Yoonha Choi, Urooj Imtiaz, Grażyna M Fedorowicz, Jessica D Anderson, Thomas V Colby, Jeffrey L Myers, David A Lynch, Kevin K Brown, Kevin R Flaherty, Mark P Steele, Steve D Groshong, Ganesh Raghu, Neil M Barth, P Sean Walsh, Jing Huang, Giulia C Kennedy, Fernando J Martinez
RATIONALE: Usual interstitial pneumonia (UIP) is the histopathologic hallmark of idiopathic pulmonary fibrosis. Although UIP can be detected by high-resolution computed tomography of the chest, the results are frequently inconclusive, and pathology from transbronchial biopsy (TBB) has poor sensitivity. Surgical lung biopsy may be necessary for a definitive diagnosis. OBJECTIVES: To develop a genomic classifier in tissue obtained by TBB that distinguishes UIP from non-UIP, trained against central pathology as the reference standard...
November 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28202859/experience-of-peripherally-inserted-central-venous-catheter-in-patients-with-hematologic-diseases
#13
Yoshinori Hashimoto, Takanori Fukuta, Junko Maruyama, Hiromi Omura, Takayuki Tanaka
Objective Although use of the peripherally inserted central venous catheter (PICC) has become increasingly common, there are few reports of PICCs used for patients with hematologic diseases. In this study, we analyzed the safety of PICC placement in patients with hematologic diseases where PICCs had been placed to perform blood collection, blood transfusion, drug administration, and hematopoietic stem cell transplantation. Methods This study included 142 PICCs placed in 95 patients managed at our department from November 2013 to December 2015...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28002967/discovery-of-1s-2r-3s-4s-5r-6r-2-amino-3-3-4-difluorophenyl-sulfanylmethyl-4-hydroxy-bicyclo-3-1-0-hexane-2-6-dicarboxylic-acid-hydrochloride-ly3020371%C3%A2-hcl-a-potent-metabotropic-glutamate-2-3-receptor-antagonist-with-antidepressant-like-activity
#14
Mark D Chappell, Renhua Li, Stephon C Smith, Bruce A Dressman, Eric G Tromiczak, Allie E Tripp, Maria-Jesus Blanco, Tatiana Vetman, Steven J Quimby, James Matt, Thomas C Britton, Adam M Fivush, Jeffrey M Schkeryantz, Daniel Mayhugh, Jon A Erickson, Mark G Bures, Carlos Jaramillo, Mercedes Carpintero, José Eugenio de Diego, Mario Barberis, Susana Garcia-Cerrada, José F Soriano, Stephen Antonysamy, Shane Atwell, Iain MacEwan, Bradley Condon, Christine Sougias, Jing Wang, Aiping Zhang, Kris Conners, Chris Groshong, Stephen R Wasserman, John W Koss, Jeffrey M Witkin, Xia Li, Carl Overshiner, Keith A Wafford, Wesley Seidel, Xu-Shan Wang, Beverly A Heinz, Steven Swanson, John T Catlow, David W Bedwell, James A Monn, Charles H Mitch, Paul L Ornstein
As part of our ongoing efforts to identify novel ligands for the metabotropic glutamate 2 and 3 (mGlu2/3) receptors, we have incorporated substitution at the C3 and C4 positions of the (1S,2R,5R,6R)-2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid scaffold to generate mGlu2/3 antagonists. Exploration of this structure-activity relationship (SAR) led to the identification of (1S,2R,3S,4S,5R,6R)-2-amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid hydrochloride (LY3020371·HCl, 19f), a potent, selective, and maximally efficacious mGlu2/3 antagonist...
December 22, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27775472/exploring-attitudes-perceived-norms-and-personal-agency-insights-into-theory-based-messages-to-encourage-park-based-physical-activity-in-low-income-urban-neighborhoods
#15
Lisa Groshong, Sonja A Wilhelm Stanis, Andrew T Kaczynski, J Aaron Hipp, Gina M Besenyi
BACKGROUND: Public parks hold promise for promoting population-level PA, but studies show a significant portion of park use is sedentary. Past research has documented the effectiveness of message-based strategies for influencing diverse behaviors in park settings and for increasing PA in nonpark contexts. Therefore, to inform message-based interventions (eg, point-ofdecision prompts) to increase park-based PA, the purpose of this study was to elicit insights about key attitudes, perceived norms, and personal agency that affect park use and park-based PA in low-income urban neighborhoods...
February 2017: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/27768210/fracture-of-totally-implanted-central-venous-access-devices-a-propensity-score-matched-comparison-of-risks-for-groshong-silicone-versus-polyurethane-catheters
#16
COMPARATIVE STUDY
Soichi Kojima, Takao Hiraki, Hideo Gobara, Toshihiro Iguchi, Hiroyasu Fujiwara, Yusuke Matsui, Toshiharu Mitsuhashi, Susumu Kanazawa
PURPOSE: To evaluate retrospectively the fracture risk of totally implanted venous access devices connected to Groshong silicone (SC) versus polyurethane (PU) catheters, inserted via the internal jugular vein. MATERIALS AND METHODS: The study population comprised 384 SC and 221 PU central venous catheters implanted via the internal jugular vein. The presence of catheter fracture was evaluated. Variables possibly related to catheter fracture were evaluated. First, in order to determine the factors associated with fracture, fracture rates were compared with the log-rank test between the two groups divided by each of the variables...
November 2, 2016: Journal of Vascular Access
https://www.readbyqxmd.com/read/27702673/mechanism-of-th2-th17-predominant-and-neutrophilic-th2-th17-low-subtypes-of-asthma
#17
Weimin Liu, Sucai Liu, Mukesh Verma, Iram Zafar, James T Good, Donald Rollins, Stephen Groshong, Magdalena M Gorska, Richard J Martin, Rafeul Alam
BACKGROUND: The mechanism of TH2/TH17-predominant and TH2/TH17-low asthma is unknown. OBJECTIVE: We sought to study the immune mechanism of TH2/TH17-predominant and TH2/TH17-low asthma. METHODS: In a previously reported cohort of 60 asthmatic patients, 16 patients were immunophenotyped with TH2/TH17-predominant asthma and 22 patients with TH2/TH17-low asthma. We examined bronchoalveolar lavage (BAL) fluid leukocytes, cytokines, mediators, and epithelial cell function for these asthma subgroups...
May 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27650251/cycle-training-modulates-satellite-cell-and-transcriptional-responses-to-a-bout-of-resistance-exercise
#18
Kevin A Murach, R Grace Walton, Christopher S Fry, Sami L Michaelis, Jason S Groshong, Brian S Finlin, Philip A Kern, Charlotte A Peterson
This investigation evaluated whether moderate-intensity cycle ergometer training affects satellite cell and molecular responses to acute maximal concentric/eccentric resistance exercise in middle-aged women. Baseline and 72 h postresistance exercise vastus lateralis biopsies were obtained from seven healthy middle-aged women (56 ± 5 years, BMI 26 ± 1, VO2max 27 ± 4) before and after 12 weeks of cycle training. Myosin heavy chain (MyHC) I- and II-associated satellite cell density and cross-sectional area was determined via immunohistochemistry...
September 2016: Physiological Reports
https://www.readbyqxmd.com/read/27438669/what-nurses-need-to-know-about-pku
#19
Janice Sampson, Megan Groshong, Denise M Wall Parilo
No abstract text is available yet for this article.
August 2016: Nursing
https://www.readbyqxmd.com/read/27266705/genome-wide-imputation-study-identifies-novel-hla-locus-for-pulmonary-fibrosis-and-potential-role-for-auto-immunity-in-fibrotic-idiopathic-interstitial-pneumonia
#20
Tasha E Fingerlin, Weiming Zhang, Ivana V Yang, Hannah C Ainsworth, Pamela H Russell, Rachel Z Blumhagen, Marvin I Schwarz, Kevin K Brown, Mark P Steele, James E Loyd, Gregory P Cosgrove, David A Lynch, Steve Groshong, Harold R Collard, Paul J Wolters, Williamson Z Bradford, Karl Kossen, Scott D Seiwert, Roland M du Bois, Christine Kim Garcia, Megan S Devine, Gunnar Gudmundsson, Helgi J Isaksson, Naftali Kaminski, Yingze Zhang, Kevin F Gibson, Lisa H Lancaster, Toby M Maher, Philip L Molyneaux, Athol U Wells, Miriam F Moffatt, Moises Selman, Annie Pardo, Dong Soon Kim, James D Crapo, Barry J Make, Elizabeth A Regan, Dinesha S Walek, Jerry J Daniel, Yoichiro Kamatani, Diana Zelenika, Elissa Murphy, Keith Smith, David McKean, Brent S Pedersen, Janet Talbert, Julia Powers, Cheryl R Markin, Kenneth B Beckman, Mark Lathrop, Brian Freed, Carl D Langefeld, David A Schwartz
BACKGROUND: Fibrotic idiopathic interstitial pneumonias (fIIP) are a group of fatal lung diseases with largely unknown etiology and without definitive treatment other than lung transplant to prolong life. There is strong evidence for the importance of both rare and common genetic risk alleles in familial and sporadic disease. We have previously used genome-wide single nucleotide polymorphism data to identify 10 risk loci for fIIP. Here we extend that work to imputed genome-wide genotypes and conduct new RNA sequencing studies of lung tissue to identify and characterize new fIIP risk loci...
June 7, 2016: BMC Genetics
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