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Daniel G Pankratz, Yoonha Choi, Urooj Imtiaz, Grażyna M Fedorowicz, Jessica D Anderson, Thomas V Colby, Jeffrey L Myers, David A Lynch, Kevin K Brown, Kevin R Flaherty, Mark P Steele, Steve D Groshong, Ganesh Raghu, Neil M Barth, P Sean Walsh, Jing Huang, Giulia C Kennedy, Fernando J Martinez
RATIONALE: Usual interstitial pneumonia (UIP) is the histopathologic hallmark of idiopathic pulmonary fibrosis. While UIP can be detected by high-resolution computed tomography (HRCT) of the chest, HRCT results are frequently inconclusive, and pathology from transbronchial biopsy (TBB) has poor sensitivity. Surgical lung biopsy (SLB) may be necessary for a definitive diagnosis. OBJECTIVES: To develop a genomic classifier in tissue obtained by TBB that distinguishes UIP from non-UIP, trained against central pathology as the reference standard...
June 22, 2017: Annals of the American Thoracic Society
Yoshinori Hashimoto, Takanori Fukuta, Junko Maruyama, Hiromi Omura, Takayuki Tanaka
Objective Although use of the peripherally inserted central venous catheter (PICC) has become increasingly common, there are few reports of PICCs used for patients with hematologic diseases. In this study, we analyzed the safety of PICC placement in patients with hematologic diseases where PICCs had been placed to perform blood collection, blood transfusion, drug administration, and hematopoietic stem cell transplantation. Methods This study included 142 PICCs placed in 95 patients managed at our department from November 2013 to December 2015...
2017: Internal Medicine
Mark D Chappell, Renhua Li, Stephon C Smith, Bruce A Dressman, Eric G Tromiczak, Allie E Tripp, Maria-Jesus Blanco, Tatiana Vetman, Steven J Quimby, James Matt, Thomas C Britton, Adam M Fivush, Jeffrey M Schkeryantz, Daniel Mayhugh, Jon A Erickson, Mark G Bures, Carlos Jaramillo, Mercedes Carpintero, José Eugenio de Diego, Mario Barberis, Susana Garcia-Cerrada, José F Soriano, Stephen Antonysamy, Shane Atwell, Iain MacEwan, Bradley Condon, Christine Sougias, Jing Wang, Aiping Zhang, Kris Conners, Chris Groshong, Stephen R Wasserman, John W Koss, Jeffrey M Witkin, Xia Li, Carl Overshiner, Keith A Wafford, Wesley Seidel, Xu-Shan Wang, Beverly A Heinz, Steven Swanson, John T Catlow, David W Bedwell, James A Monn, Charles H Mitch, Paul L Ornstein
As part of our ongoing efforts to identify novel ligands for the metabotropic glutamate 2 and 3 (mGlu2/3) receptors, we have incorporated substitution at the C3 and C4 positions of the (1S,2R,5R,6R)-2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid scaffold to generate mGlu2/3 antagonists. Exploration of this structure-activity relationship (SAR) led to the identification of (1S,2R,3S,4S,5R,6R)-2-amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid hydrochloride (LY3020371·HCl, 19f), a potent, selective, and maximally efficacious mGlu2/3 antagonist...
December 22, 2016: Journal of Medicinal Chemistry
Lisa Groshong, Sonja A Wilhelm Stanis, Andrew T Kaczynski, J Aaron Hipp, Gina M Besenyi
BACKGROUND: Public parks hold promise for promoting population-level PA, but studies show a significant portion of park use is sedentary. Past research has documented the effectiveness of message-based strategies for influencing diverse behaviors in park settings and for increasing PA in nonpark contexts. Therefore, to inform message-based interventions (eg, point-ofdecision prompts) to increase park-based PA, the purpose of this study was to elicit insights about key attitudes, perceived norms, and personal agency that affect park use and park-based PA in low-income urban neighborhoods...
February 2017: Journal of Physical Activity & Health
Soichi Kojima, Takao Hiraki, Hideo Gobara, Toshihiro Iguchi, Hiroyasu Fujiwara, Yusuke Matsui, Toshiharu Mitsuhashi, Susumu Kanazawa
PURPOSE: To evaluate retrospectively the fracture risk of totally implanted venous access devices connected to Groshong silicone (SC) versus polyurethane (PU) catheters, inserted via the internal jugular vein. MATERIALS AND METHODS: The study population comprised 384 SC and 221 PU central venous catheters implanted via the internal jugular vein. The presence of catheter fracture was evaluated. Variables possibly related to catheter fracture were evaluated. First, in order to determine the factors associated with fracture, fracture rates were compared with the log-rank test between the two groups divided by each of the variables...
November 2, 2016: Journal of Vascular Access
Weimin Liu, Sucai Liu, Mukesh Verma, Iram Zafar, James T Good, Donald Rollins, Stephen Groshong, Magdalena M Gorska, Richard J Martin, Rafeul Alam
BACKGROUND: The mechanism of TH2/TH17-predominant and TH2/TH17-low asthma is unknown. OBJECTIVE: We sought to study the immune mechanism of TH2/TH17-predominant and TH2/TH17-low asthma. METHODS: In a previously reported cohort of 60 asthmatic patients, 16 patients were immunophenotyped with TH2/TH17-predominant asthma and 22 patients with TH2/TH17-low asthma. We examined bronchoalveolar lavage (BAL) fluid leukocytes, cytokines, mediators, and epithelial cell function for these asthma subgroups...
May 2017: Journal of Allergy and Clinical Immunology
Kevin A Murach, R Grace Walton, Christopher S Fry, Sami L Michaelis, Jason S Groshong, Brian S Finlin, Philip A Kern, Charlotte A Peterson
This investigation evaluated whether moderate-intensity cycle ergometer training affects satellite cell and molecular responses to acute maximal concentric/eccentric resistance exercise in middle-aged women. Baseline and 72 h postresistance exercise vastus lateralis biopsies were obtained from seven healthy middle-aged women (56 ± 5 years, BMI 26 ± 1, VO2max 27 ± 4) before and after 12 weeks of cycle training. Myosin heavy chain (MyHC) I- and II-associated satellite cell density and cross-sectional area was determined via immunohistochemistry...
September 2016: Physiological Reports
Janice Sampson, Megan Groshong, Denise M Wall Parilo
No abstract text is available yet for this article.
August 2016: Nursing
Tasha E Fingerlin, Weiming Zhang, Ivana V Yang, Hannah C Ainsworth, Pamela H Russell, Rachel Z Blumhagen, Marvin I Schwarz, Kevin K Brown, Mark P Steele, James E Loyd, Gregory P Cosgrove, David A Lynch, Steve Groshong, Harold R Collard, Paul J Wolters, Williamson Z Bradford, Karl Kossen, Scott D Seiwert, Roland M du Bois, Christine Kim Garcia, Megan S Devine, Gunnar Gudmundsson, Helgi J Isaksson, Naftali Kaminski, Yingze Zhang, Kevin F Gibson, Lisa H Lancaster, Toby M Maher, Philip L Molyneaux, Athol U Wells, Miriam F Moffatt, Moises Selman, Annie Pardo, Dong Soon Kim, James D Crapo, Barry J Make, Elizabeth A Regan, Dinesha S Walek, Jerry J Daniel, Yoichiro Kamatani, Diana Zelenika, Elissa Murphy, Keith Smith, David McKean, Brent S Pedersen, Janet Talbert, Julia Powers, Cheryl R Markin, Kenneth B Beckman, Mark Lathrop, Brian Freed, Carl D Langefeld, David A Schwartz
BACKGROUND: Fibrotic idiopathic interstitial pneumonias (fIIP) are a group of fatal lung diseases with largely unknown etiology and without definitive treatment other than lung transplant to prolong life. There is strong evidence for the importance of both rare and common genetic risk alleles in familial and sporadic disease. We have previously used genome-wide single nucleotide polymorphism data to identify 10 risk loci for fIIP. Here we extend that work to imputed genome-wide genotypes and conduct new RNA sequencing studies of lung tissue to identify and characterize new fIIP risk loci...
2016: BMC Genetics
Ted Groshong
No abstract text is available yet for this article.
November 2015: Missouri Medicine
Renata Błasiak, Michał Ławiński, Krystyna Majewska, Aleksandra Gradowska
UNLABELLED: According to the ESPEN and ASPEN guidelines, in the case of a long-term (>3-month) parenteral nutrition should be administered via a subcutaneous central venous catheter (CVC). There are three types of mechanical complications of tunnelled central catheter: catheter rupture, occlusion by TPN depositing and thrombofibrotic occlusion. The aim of the study was to analyse the incidence of complications central catheter in a group of patients receiving HPN. MATERIAL AND METHODS: Between January 2010 and June 2014, HPN was conducted in 584 patients (306 women and 278 men), ninety-nine patients were enrolled in the study: 67 women and 32 men in whom mechanical complications of central catheters were found...
November 2015: Polski Przeglad Chirurgiczny
Matthew A Schiffler, Stephen Antonysamy, Shobha N Bhattachar, Kristina M Campanale, Srinivasan Chandrasekhar, Bradley Condon, Prashant V Desai, Matthew J Fisher, Christopher Groshong, Anita Harvey, Michael J Hickey, Norman E Hughes, Scott A Jones, Euibong J Kim, Steven L Kuklish, John G Luz, Bryan H Norman, Richard E Rathmell, John R Rizzo, Thomas W Seng, Stefan J Thibodeaux, Timothy A Woods, Jeremy S York, Xiao-Peng Yu
As part of a program aimed at the discovery of antinociceptive therapy for inflammatory conditions, a screening hit was found to inhibit microsomal prostaglandin E synthase-1 (mPGES-1) with an IC50 of 17.4 μM. Structural information was used to improve enzyme potency by over 1000-fold. Addition of an appropriate substituent alleviated time-dependent cytochrome P450 3A4 (CYP3A4) inhibition. Further structure-activity relationship (SAR) studies led to 8, which had desirable potency (IC50 = 12 nM in an ex vivo human whole blood (HWB) assay) and absorption, distribution, metabolism, and excretion (ADME) properties...
January 14, 2016: Journal of Medicinal Chemistry
Milamari A Cunningham, Elizabeth James, Ted Groshong, Patricia J Blair, Giorgi Tsilosani
No abstract text is available yet for this article.
September 2015: Missouri Medicine
Beau Wager, Dana K Shaw, Ashley M Groshong, Jon S Blevins, Jon T Skare
Borrelia burgdorferi, the etiologic agent of Lyme disease, produces a variety of proteins that promote survival and colonization in both the Ixodes species vector and various mammalian hosts. We initially identified BB0744 (also known as p83/100) by screening for B. burgdorferi strain B31 proteins that bind to α1β1 integrin and hypothesized that, given the presence of a signal peptide, BB0744 may be a surface-exposed protein. In contrast to this expectation, localization studies suggested that BB0744 resides in the periplasm...
September 2015: Infection and Immunity
James R Henry, Michael D Kaufman, Sheng-Bin Peng, Yu Mi Ahn, Timothy M Caldwell, Lakshminarayana Vogeti, Hanumaiah Telikepalli, Wei-Ping Lu, Molly M Hood, Thomas J Rutkoski, Bryan D Smith, Subha Vogeti, David Miller, Scott C Wise, Lawrence Chun, Xiaoyi Zhang, Youyan Zhang, Lisa Kays, Philip A Hipskind, Aaron D Wrobleski, Karen L Lobb, Julia M Clay, Jeffrey D Cohen, Jennie L Walgren, Denis McCann, Phenil Patel, David K Clawson, Sherry Guo, Danalyn Manglicmot, Chris Groshong, Cheyenne Logan, James J Starling, Daniel L Flynn
The RAS-RAF-MEK-MAPK cascade is an essential signaling pathway, with activation typically mediated through cell surface receptors. The kinase inhibitors vemurafenib and dabrafenib, which target oncogenic BRAF V600E, have shown significant clinical efficacy in melanoma patients harboring this mutation. Because of paradoxical pathway activation, both agents were demonstrated to promote growth and metastasis of tumor cells with RAS mutations in preclinical models and are contraindicated for treatment of cancer patients with BRAF WT background, including patients with KRAS or NRAS mutations...
May 28, 2015: Journal of Medicinal Chemistry
Michael P Mohning, William J Janssen, Steve D Groshong, E Michael Canham
No abstract text is available yet for this article.
March 2015: Annals of the American Thoracic Society
Ted Groshong
No abstract text is available yet for this article.
November 2014: Missouri Medicine
Jonathan A Kropski, Jason M Pritchett, Donald F Zoz, Peter F Crossno, Cheryl Markin, Errine T Garnett, Amber L Degryse, Daphne B Mitchell, Vasiliy V Polosukhin, Otis B Rickman, Leena Choi, Dong-Sheng Cheng, Melinda E McConaha, Brittany R Jones, Linda A Gleaves, Frank B McMahon, John A Worrell, Joseph F Solus, Lorraine B Ware, Jae Woo Lee, Pierre P Massion, Rinat Zaynagetdinov, Eric S White, Jonathan D Kurtis, Joyce E Johnson, Steve D Groshong, Lisa H Lancaster, Lisa R Young, Mark P Steele, John A Phillips Iii, Joy D Cogan, James E Loyd, William E Lawson, Timothy S Blackwell
RATIONALE: Asymptomatic relatives of patients with familial interstitial pneumonia (FIP), the inherited form of idiopathic interstitial pneumonia, carry increased risk for developing interstitial lung disease. OBJECTIVES: Studying these at-risk individuals provides a unique opportunity to investigate early stages of FIP pathogenesis and develop predictive models of disease onset. METHODS: Seventy-five asymptomatic first-degree relatives of FIP patients (mean age, 50...
February 15, 2015: American Journal of Respiratory and Critical Care Medicine
Jonathan H Chung, Ashish Chawla, Anna L Peljto, Carlyne D Cool, Steve D Groshong, Janet L Talbert, David F McKean, Kevin K Brown, Tasha E Fingerlin, Marvin I Schwarz, David A Schwartz, David A Lynch
BACKGROUND: The current usual interstitial pneumonitis (UIP)/idiopathic pulmonary fibrosis CT scan classification system excludes probable UIP as a diagnostic category. We sought to determine the predictive effect of probable UIP on CT scan on histology and the effect of the promoter polymorphism in MUC5B (rs35705950) on histologic and CT scan UIP diagnosis. METHODS: The cohort included 201 subjects with pulmonary fibrosis who had lung tissue samples obtained within 1 year of chest CT scan...
February 2015: Chest
Michael Russell, Theodore Goodman, Qiang Wang, Bennett Groshong, Bruce G Lyeth
Low current transcranial electrical stimulation (tCS) is an effective but somewhat inconsistent tool for augmenting neuromodulation. In this study, we used 3D MRI guided electrical transcranial stimulation modeling to estimate the range of current intensities received at cortical brain tissues. Combined T1, T2, and proton density MRIs from 24 adult subjects (12 male and 12 female) were modeled with virtual electrodes placed at F3, F4, C3, and C4. Two sizes of electrodes 20 mm round and 50 mm × 45 mm were examined at 0...
2014: Frontiers in Psychiatry
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