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https://www.readbyqxmd.com/read/28304154/nanostructured-thermal-responsive-materials-synthesized-by-soft-templating
#1
Cedric Vancaeyzeele, Florian Olivier, Gwendoline Petroffe, Sebastien Peralta, Frederic Vidal
We capitalized herein the inherent tortuosity of bicontinuous microemulsion to conceive nanostructured drug delivery devices. First, we show that it is possible to synthesize bicontinuous materials with continuous hydrophilic domains of PNIPAM network entangled with continuous hydrophobic polymer domains, dual phase continuity being imposed by the bicontinuous microemulsions used as soft template. A particular attention is paid to the microemulsion formulations using a surfmer to preserve the one-to-one replication of the bicontinuous nanostructure after polymerization...
March 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28296671/the-use-of-thrombolytic-therapy-in-the-treatment-of-frostbite-injury
#2
Allyson Wexler, Sarah Zavala
Frostbite can lead to severe consequences including loss of digits and limbs. One of the mechanisms of frostbite includes vascular thrombosis. The use of tissue plasminogen activator (tPA) in frostbite has been shown to be effective in case reports and small prospective studies. A retrospective chart review was performed on all patients admitted for frostbite between January 2008 and April 2015, and six patients were identified as having received treatment with intravenous tPA. Patients received an initial bolus dose followed by a 6-hour infusion of tPA...
March 3, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28279492/group-2-innate-lymphoid-cells-are-recruited-to-the-nasal-mucosa-in-patients-with-aspirin-exacerbated-respiratory-disease
#3
Jacqueline J Eastman, Kellen J Cavagnero, Adam S Deconde, Alex S Kim, Maya R Karta, David H Broide, Bruce L Zuraw, Andrew A White, Sandra C Christiansen, Taylor A Doherty
BACKGROUND: Aspirin-exacerbated respiratory disease (AERD) is characterized by tissue eosinophilia and mast cell activation, including abundant production of prostaglandin D2 (PGD2). Group 2 innate lymphoid cells (ILC2s), which promote tissue eosinophilia and mast cell responses, undergo chemotaxis and cytokine production in response to PGD2, but it is unknown whether ILC2s are active in patients with AERD. OBJECTIVE: We sought to determine whether ILC2 numbers change in peripheral blood and the nasal mucosa during COX-1 inhibitor-induced reactions in patients with AERD...
January 27, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28277060/thrombelastographic-hypercoagulability-and-antiplatelet-therapy-after-coronary-artery-bypass-surgery-teg-cabg-trial-a-randomized-controlled-trial
#4
Sulman Rafiq, Pär I Johansson, Klaus F Kofoed, Jens T Lund, Peter S Olsen, Simon Bentsen, Daniel A Steinbrüchel
A hypercoagulable state has, in observational studies, been associated with increased risk of thromboembolic events. The aim of this trial was to study whether dual antiplatelet therapy (DAPT) with clopidogrel in addition to aspirin could reduce the rate of graft occlusions, thromboembolic events, and death compared to aspirin monotherapy in hypercoagulable patients undergoing coronary artery bypass surgery. A total of 1683 patients were screened for eligibility, among which 165 patients were randomized and 133 patients underwent multislice computed tomography scan to evaluate their grafts...
February 22, 2017: Platelets
https://www.readbyqxmd.com/read/28267249/once-versus-twice-daily-aspirin-after-coronary-bypass-surgery-a-randomized-trial
#5
J S Paikin, J Hirsh, J S Ginsberg, J I Weitz, N C Chan, R P Whitlock, G Pare, J W Eikelboom
BACKGROUND: Acetyl-salicylic acid (ASA) hyporesponsiveness occurs transiently after coronary artery bypass graft surgery (CABG) surgery and may compromise the effectiveness of ASA to reduce thrombotic graft failure. Reduced response to ASA 81mg once-daily after CABG surgery is overcome by four times-daily ASA dosing. OBJECTIVES: To determine whether ASA 325mg once-daily or 162mg twice-daily overcomes reduced response to ASA 81mg once-daily after CABG surgery. METHODS: Adults undergoing CABG surgery were randomized to ASA 81mg once-daily, 325mg once-daily or 162mg twice-daily...
March 7, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28261551/odd-couple-the-unexpected-partnership-of-glucocorticoid-hormones-and-cysteinyl-leukotrienes-in-the-extrinsic-regulation-of-murine-bone-marrow-eosinopoiesis
#6
REVIEW
Pedro Xavier-Elsas, Daniela Masid-de-Brito, Bruno Marques Vieira, Maria Ignez C Gaspar-Elsas
Granulopoiesis in murine bone-marrow is regulated by both intrinsic and extrinsic factors (including hormones, drugs, inflammatory mediators and cytokines). Eosinophils, a minor subpopulation of circulating leukocytes, which remains better understood in its contributions to tissue injury in allergic disease than in its presumably beneficial actions in host defense, provide a striking example of joint regulation of granulopoiesis within murine bone-marrow by all of these classes of extrinsic factors. We first described the upregulation of eosinopoiesis in bone-marrow of allergen-sensitized mice following airway allergen challenge...
February 20, 2017: World Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28245774/potential-usefulness-of-clopidogrel-pharmacogenetics-in-cerebral-endovascular-procedures-and-carotid-artery-stenting
#7
Jorge Duconge, Dagmar F Hernandez-Suarez
BACKGROUND: Previous reports have shown inadequate response to dual antiplatelet therapy (DAPT) with aspirin and clopidogrel in 5-30% of patients undergoing percutaneous coronary interventions (PCI), due mostly to clopidogrel resistance. This prevalence increases up to 66% in patients undergoing neurointerventional procedures. However, clinical significance of CYP2C19 genotypes in neurointerventional procedures or carotid artery stenting (CAS) is unknown. OBJECTIVE: The purpose of this review is to update our current knowledge and understanding of the pharmacogenetic basis for poor clopidogrel responsiveness in patients undergoing CAS and endovascular interventions as well as to explore usefulness of genotyping to reduce the rate of procedure-related thrombosis that results in ischemic complications...
February 27, 2017: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/28244660/bioactive-food-chemicals-and-gastrointestinal-symptoms-a-focus-of-salicylates
#8
REVIEW
Sreepurna Malakar
Bioactive food chemicals are substances present in food that are capable of interacting with living cells causing changes in physiological functions. Salicylic acid (SA), a plant hormone involved in plant immune response, is one such bioactive food chemical. Aspirin, a commercially available SA, might play beneficial roles in cardiovascular health and colon cancer. It may also cause urticaria, angioedema, asthma, and gastrointestinal symptoms in SA-sensitive individuals. Dietary SA might exert similar beneficial effects and/or may induce similar symptoms in hypersensitive individuals...
March 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28237086/pseudomonas-aeruginosa-produces-aspirin-insensitive-eicosanoids-and-contributes-to-the-eicosanoid-profile-of-polymicrobial-biofilms-with-candida-albicans
#9
Ruan Fourie, Ruan Ells, Gabré Kemp, Olihile M Sebolai, Jacobus Albertyn, Carolina H Pohl
The interaction of clinically relevant microorganisms is the focus of various studies, e.g. the interaction between the pathogenic yeast, Candida albicans, and the bacterium, Pseudomonas aeruginosa. During infection both release arachidonic acid, which they can transform into eicosanoids. This study evaluated the production of prostaglandin E2, prostaglandin F2α and 15-hydroxyeicosatetraenoic acid by biofilms of P. aeruginosa and C. albicans. The influence of co-incubation, acetylsalicylic acid and nordihydroguaiaretic acid on biofilm formation and eicosanoid production was evaluated...
February 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28219002/molecular-testing-for-gastrointestinal-cancer
#10
REVIEW
Hye Seung Lee, Woo Ho Kim, Yoonjin Kwak, Jiwon Koh, Jeong Mo Bae, Kyoung-Mee Kim, Mee Soo Chang, Hye Seung Han, Joon Mee Kim, Hwal Woong Kim, Hee Kyung Chang, Young Hee Choi, Ji Y Park, Mi Jin Gu, Min Jin Lhee, Jung Yeon Kim, Hee Sung Kim, Mee-Yon Cho
With recent advances in molecular diagnostic methods and targeted cancer therapies, several molecular tests have been recommended for gastric cancer (GC) and colorectal cancer (CRC). Microsatellite instability analysis of gastrointestinal cancers is performed to screen for Lynch syndrome, predict favorable prognosis, and screen patients for immunotherapy. The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor has been approved in metastatic CRCs with wildtype RAS (KRAS and NRAS exon 2-4). A BRAF mutation is required for predicting poor prognosis...
March 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28213094/aspirin-triggered-resolvin-d1-modified-materials-promote-the-accumulation-of-pro-regenerative-immune-cell-subsets-and-enhance-vascular-remodeling
#11
Mary Caitlin P Sok, Maxianne C Tria, Claire E Olingy, Cheryl L San Emeterio, Edward A Botchwey
Many goals in tissue engineering rely on modulating cellular localization and polarization of cell signaling, including the inhibition of inflammatory infiltrate, facilitation of inflammatory cell egress, and clearance of apoptotic cells. Omega-3 polyunsaturated fatty acid-derived resolvins are gaining increasing recognition for their essential roles in inhibition of neutrophil invasion into inflamed tissue and promotion of macrophage phagocytosis of cellular debris as well as their egress to the lymphatics...
February 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28210259/resolution-of-cancer-promoting-inflammation-a-new-approach-for-anticancer-therapy
#12
REVIEW
Qi Zhang, Bo Zhu, Yongsheng Li
Inflammation is a protective response that eliminates harmful stimuli and restores tissue homeostasis, whereas the failure to resolve inflammation leads to the development of malignancies. Immune cells in the tumor inflammatory microenvironment endow cancer cells with their specific hallmarks, including mutations, metabolic reprograming, angiogenesis, invasion, and metastasis. Targeting the inflammatory microenvironment with anti-inflammatory drugs (e.g., aspirin) or by enhancing antitumor immunity (e.g., chimeric antigen receptor T cell therapy) has been extensively investigated and has achieved promising results in many cancers...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28178170/use-of-susceptibility-weighted-imaging-in-assessing-ischemic-penumbra-a-case-report
#13
Xiujuan Wu, Song Luo, Ying Wang, Yang Chen, Jun Liu, Jing Bai, Jiachun Feng, Hongliang Zhang
RATIONALE: The ischemic penumbra assessment is essential for the subsequent therapy and prediction of evolution in patients with acute ischemic infraction. Although controversial as a perfect equivalence to penumbra, perfusion-weighted imaging (PWI)-diffusion-weighted imaging (DWI) mismatch may predict the response to thrombolysis. Due to the reliance of PWI on contrast agents, noninvasive alternatives remain an unmet need. PATIENT CONCERNS: We reported a 65-year-old man complained of paroxysmal hemiplegia of his right limbs and anepia for 2 days, whereas the symptoms lasted for about 12 hours when he admitted to the hospital...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28175380/100%C3%A2-differential-sex-response-to-aspirin-in-decreasing-aneurysm-rupture-in-humans-and-mice
#14
Nohra Chalouhi, Robert M Starke, Tatiana Correa, Pascal Jabbour, Mario Zanaty, Robert Brown, James Torner, David M Hasan
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28174051/simvastatin-protects-human-melanocytes-from-h2o2-induced-oxidative-stress-by-activating-nrf2
#15
Yuqian Chang, Shuli Li, Weinan Guo, Yuqi Yang, Weigang Zhang, Qian Zhang, Yuanmin He, Xiuli Yi, Tingting Cui, Yawen An, Pu Song, Zhe Jian, Ling Liu, Kai Li, Gang Wang, Tianwen Gao, Lin Wang, Chunying Li
The prevention of hydrogen peroxide (H2O2)-induced oxidative stress has been proved to be beneficial to vitiligo patients. Simvastatin possesses anti-oxidative capacity and has shown protective effect in various oxidative stress-related diseases. However, whether simvastatin can protect human melanocytes against oxidative stress has not been investigated. In the present study, we initially found that pre-treatment of 0.1 μM to 1.0 μM simvastatin led to increased cell viability and decreased cell apoptosis of melanocytes in response to H2O2...
February 4, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28173738/pregnancy-failure-in-patients-with-obstetric-antiphospholipid-syndrome-with-conventional-treatment-the-influence-of-a-triple-positive-antibody-profile
#16
J O Latino, S Udry, F M Aranda, S D A Perés Wingeyer, D S Fernández Romero, G F de Larrañaga
Conventional treatment of obstetric antiphospholipid syndrome fails in approximately 20-30% of pregnant women without any clearly identified risk factor. It is important to identify risk factors that are associated with these treatment failures. This study aimed to assess the impact of risk factors on pregnancy outcomes in women with obstetric antiphospholipid syndrome treated with conventional treatment. We carefully retrospectively selected 106 pregnancies in women with obstetric antiphospholipid syndrome treated with heparin + aspirin...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28167931/the-active-component-of-aspirin-salicylic-acid-promotes-staphylococcus-aureus-biofilm-formation-in-a-pia-dependent-manner
#17
Cristian Dotto, Andrea Lombarte Serrat, Natalia Cattelan, María S Barbagelata, Osvaldo M Yantorno, Daniel O Sordelli, Monika Ehling-Schulz, Tom Grunert, Fernanda R Buzzola
Aspirin has provided clear benefits to human health. But salicylic acid (SAL) -the main aspirin biometabolite- exerts several effects on eukaryote and prokaryote cells. SAL can affect, for instance, the expression of Staphylococcus aureus virulence factors. SAL can also form complexes with iron cations and it has been shown that different iron chelating molecules diminished the formation of S. aureus biofilm. The aim of this study was to elucidate whether the iron content limitation caused by SAL can modify the S...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28160159/aspirin-use-is-associated-with-lower-mammographic-density-in-a-large-screening-cohort
#18
REVIEW
Marie E Wood, Brian L Sprague, Andrew Oustimov, Marie B Synnstvedt, Melissa Cuke, Emily F Conant, Despina Kontos
BACKGROUND: Observational and biologic studies suggest that aspirin is a promising prevention therapy for breast cancer. However, clinical trials to date have not corroborated this evidence, potentially due to study design. We evaluated the effect of aspirin on mammographic density (MD), an established modifiable risk factor for breast cancer. METHODS: Electronic medical records from the University of Pennsylvania were evaluated for women who underwent screening mammography, saw their primary care provider, and had a confirmed list of medications during 2012-2013...
February 4, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28154807/hypersensitivity-to-ticagrelor-and-low-response-to-clopidogrel-a-case-report
#19
Jing Dai, Shuzheng Lyu, Changjiang Ge
Ticagrelor is widely used to treat acute coronary syndrome. Hypersensitivity reaction of ticagrelor is rarely recognized. A low response to clopidogrel, which occurs in up to 23% of patients, is an independent risk factor for stent thrombosis. Management of patients with a low response to clopidogrel and ticagrelor hypersensitivity who are undergoing antithrombotic therapy remains to be a challenge. Herein, we report a patient with low response to clopidogrel and ticagrelor hypersensitivity, who was successfully managed using aspirin and warfarin...
January 2017: Asia Pacific Allergy
https://www.readbyqxmd.com/read/28154202/aspirin-induced-chemoprevention-and-response-kinetics-are-enhanced-by-pik3ca-mutations-in-colorectal-cancer-cells
#20
Timothy J Zumwalt, Dominik Wodarz, Natalia L Komarova, Shusuke Toden, Jacob Turner, Jacob Cardenas, John Burn, Andrew T Chan, C Richard Boland, Ajay Goel
This study was designed to determine how aspirin influences the growth kinetics and characteristics of cultured colorectal cancer cells that harbor a variety of different mutational backgrounds, including PIK3CA- and KRAS-activating mutations, and the presence or absence of microsatellite instability. Colorectal cancer cell lines (HCT116, HCT116 + Chr3/5, RKO, SW480, HCT15, CACO2, HT29, and SW48) were treated with pharmacologically relevant doses of aspirin (0.5-10 mmol/L) and evaluated for proliferation and cell-cycle distribution...
March 2017: Cancer Prevention Research
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