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Surgery and ibd

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https://www.readbyqxmd.com/read/28426451/quality-of-care-and-outcomes-among-hospitalized-inflammatory-bowel-disease-patients-a-multicenter-retrospective-study
#1
Geoffrey C Nguyen, Sanjay K Murthy, Brian Bressler, Mindy C W Lam, Ali Alali, Asmae Toumi, Jason Reinglas, Adam Rampersad, Adam V Weizman, Waqqas Afif
BACKGROUND: Half of patients with inflammatory bowel disease (IBD) require hospitalization. We sought to characterize inpatient quality indicators of care and outcomes during IBD-related hospitalizations at 4 major IBD referral centers in Canada. METHODS: We conducted a multicenter retrospective cohort study of patients with IBD admitted from 2011 to 2013 to tertiary centers in Toronto, Montreal, Ottawa, and Vancouver. We assessed the following inpatient indicators of care: pharmacological venous thromboembolism (VTE) prophylaxis, Clostridium difficile testing, and medical rescue therapy for steroid-refractory ulcerative colitis (UC)...
May 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28410345/development-of-a-novel-predictive-model-for-the-clinical-course-of-crohn-s-disease-results-from-the-connect-study
#2
Yehyun Park, Jae Hee Cheon, Yi Lang Park, Byong Duk Ye, You Sun Kim, Dong Soo Han, Joo Sung Kim, Sung Noh Hong, Young Ho Kim, Seong Ran Jeon, Won Ho Kim
BACKGROUND: A considerable number of patients with Crohn's disease (CD) develop irreversible intestinal damage, although the early administration of immunomodulatory or biological therapies might prevent this. The aims of our study were to develop and validate a novel predictive model that can be used to predict the risk of surgical intervention in Korean patients with CD. METHODS: The prognostic model was derived from the multicenter longitudinal CONNECT (CrOhn's disease cliNical NEtwork and CohorT) study cohort consisting of 1338 patients with CD, who were split into training and validation sets...
April 13, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28410342/sarcopenia-is-common-in-overweight-patients-with-inflammatory-bowel-disease-and-may-predict-need-for-surgery
#3
Dawn W Adams, Shelly Gurwara, Heidi J Silver, Sara N Horst, Dawn B Beaulieu, David A Schwartz, Douglas L Seidner
BACKGROUND: Inflammatory bowel disease (IBD) is associated with altered body composition, such as low muscle mass, which affects clinical outcomes. Body composition changes in overweight patients with IBD are less understood. The study aim was to determine the prevalence of sarcopenic overweight and obese patients in a cohort of patients with IBD starting new anti-tumor necrosis factor-α therapy and examine differences in response. METHODS: This is a retrospective review of patients with IBD starting a new anti-tumor necrosis factor-α medication that had computed tomography within 3 months of initiation...
April 13, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28410340/inflammatory-bowel-disease-is-similar-in-patients-with-older-onset-and-younger-onset
#4
Bharati Kochar, Millie D Long, Joseph Galanko, Laura E Raffals, Ashwin Ananthakrishnan, Robert S Sandler
BACKGROUND: As the American population is aging, the number of older people with inflammatory bowel disease is increasing. We used clinical data from the Sinai-Helmsley Alliance for Research Excellence (SHARE), a prospective cohort, to examine disease and treatment differences in older adults. METHODS: We performed a cross-sectional study assessing demographics and disease behavior by age at diagnosis with univariate, bivariate, and multivariate analyses. "Older-onset" patients were diagnosed after age 60, "younger-onset" patients were diagnosed before age 60 but are older than 60 years, and the remainder were "young...
April 13, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28408996/risk-factors-for-complications-after-ileocolonic-resection-for-crohn-s-disease-with-a-major-focus-on-the-impact-of-preoperative-immunosuppressive-and-biologic-therapy-a-retrospective-international-multicentre-study
#5
Takayuki Yamamoto, Antonino Spinelli, Yasuo Suzuki, Rogerio Saad-Hossne, Fabio Vieira Teixeira, Idblan Carvalho de Albuquerque, Rodolff Nunes da Silva, Ivan Folchini de Barcelos, Ken Takeuchi, Akihiro Yamada, Takahiro Shimoyama, Lorete Maria da Silva Kotze, Matteo Sacchi, Silvio Danese, Paulo Gustavo Kotze
BACKGROUND: Author note: TY, AS, YS, FVT and PGK designed the study. All authors did data collection and gave scientific contribution to the study design and discussion. TY, AS and PGK drafted the article. All authors read and approved the final version of the manuscript.In the era of biologic agents, risk factors for complications following resection for Crohn's disease have not been fully identified. In particular, the association of preoperative use of immunosuppressive and biologic agents with the incidence of complications after resection remains to be elucidated...
December 2016: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28402523/role-of-short-chain-fatty-acids-in-colonic-inflammation-carcinogenesis-and-mucosal-protection-and-healing
#6
Christina M van der Beek, Cornelis H C Dejong, Freddy J Troost, Ad A M Masclee, Kaatje Lenaerts
Short-chain fatty acids (SCFAs), mainly acetate, propionate, and butyrate, produced by microbial fermentation of undigested food substances are believed to play a beneficial role in human gut health. Short-chain fatty acids influence colonic health through various mechanisms. In vitro and ex vivo studies show that SCFAs have anti-inflammatory and anticarcinogenic effects, play an important role in maintaining metabolic homeostasis in colonocytes, and protect colonocytes from external harm. Animal studies have found substantial positive effects of SCFAs or dietary fiber on colonic disease, but convincing evidence in humans is lacking...
April 10, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28401051/surgery-in-pediatric-crohn-s-disease-indications-timing-and-post-operative-management
#7
REVIEW
Seung Kim
Pediatric onset Crohn's disease (CD) tends to have complicated behavior (stricture or penetration) than elderly onset CD at diagnosis. Considering the longer duration of the disease in pediatric patients, the accumulative chance of surgical treatment is higher than in adult onset CD patients. Possible operative indications include perianal CD, intestinal stricture or obstruction, abdominal abscess or fistula, intestinal hemorrhage, neoplastic changes and medically untreatable inflammation. Growth retardation is an operative indication only for pediatric patients...
March 2017: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/28400196/association-of-rnaset2-gene-polymorphisms-with-decreased-expression-and-clinical-characteristics-of-severity-in-crohn-s-disease
#8
Rivkah Gonsky, Phillip Fleshner, Richard L Deem, Eva Biener-Ramanujan, Dalin Li, Alka A Potdar, Janine Bilsborough, Shaohong Yang, Dermot P B McGovern, Stephan R Targan
BACKGROUND & AIMS: Variants in the tumor necrosis factor superfamily member 15 gene (TNFSF15, also called TL1A) have been associated with risk for inflammatory bowel diseases (IBD). TL1A affects expression of multiple cytokines to promote mucosal inflammation. Little is known about the TL1A-response pathways that regulate cytokine expression. We investigated T-cell gene expression patterns to determine the mechanisms by which TL1A regulates cytokine production, and whether these associate with outcomes of patients with Crohn's disease (CD)...
April 8, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28397701/cytomegalovirus-infection-associated-with-inflammatory-bowel-disease
#9
REVIEW
Britta Siegmund
Refractory colitis in patients with inflammatory bowel disease is a complicated clinical disorder that might, in some patients, even necessitate surgery. Hence the diagnosis of additional complications is of utmost importance. Colitis mediated by cytomegalovirus is one such complication. The high seroprevalence and latent nature of cytomegalovirus, with the possibility of viral replication without mediating disease, poses a real challenge for the diagnosis of cytomegalovirus-mediated colitis. The challenge in daily clinical practice is to distinguish cytomegalovirus replication from cytomegalovirus-mediated colitis in patients with inflammatory bowel disease who have refractory colitis...
May 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28391412/role-of-mirnas-in-inflammatory-bowel-disease
#10
REVIEW
Bo Cao, Xin Zhou, Jiaojiao Ma, Wei Zhou, Wanli Yang, Daiming Fan, Liu Hong
Inflammatory bowel diseases (IBD), mainly including Crohn's disease and ulcerative colitis, are characterized by chronic inflammation of the gastrointestinal tract. Despite improvements in detection, drug treatment and surgery, the pathogenesis of IBD has not been clarified. A number of miRNAs have been found to be involved in the initiation, development and progression of IBD, and they may have the potential to be used as biomarkers and therapeutic targets. Here, we have summarized the recent advances about the roles of miRNAs in IBD and analyzed the contribution of miRNAs to general diagnosis, differential diagnosis and activity judgment of IBD...
April 8, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28381939/laparoscopy-for-benign-diseases-of-the-colon
#11
REVIEW
Radhika Smith, David J Maron
Laparoscopic surgery has revolutionized the delivery of care to the surgical patient undergoing colorectal resection. Since the first laparoscopic-assisted colectomy in 1991, significant advances have been made in minimally invasive colorectal surgery. For many benign conditions, laparoscopic colectomy has been proven to be safe and effective, and in some instances superior when compared with open surgery. Complex laparoscopic resections such as those for diverticulitis and inflammatory bowel disease have also been shown to have equivalent outcomes when compared with open surgery...
April 2017: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/28379857/postsurgical-pyoderma-gangrenosum-versus-necrotizing-fasciitis-can-we-spot-the-difference
#12
Leila L Touil, Dilnath A R Gurusinghe, Amir Sadri, Ahmed El-Gawad, Fahmy S Fahmy
BACKGROUND: Pyoderma gangrenosum is a rare noninfectious cutaneous disease characterized by expanding areas of skin ulceration around necrotic centers with purulent debris. Exceptionally, it can be precipitated by surgery alone, and this entity has been described as postsurgical pyoderma gangrenosum (PSPG). Cases of PSPG in the literature are rare. METHODS: We performed a retrospective review of the current literature on PSPG and highlight some observed differences between these conditions...
May 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28378692/can-we-predict-disease-course-with-clinical-factors
#13
Zsuzsanna Vegh, Zsuzsanna Kurti, Petra Anna Golovics, Laszlo Lakatos
The disease phenotype at diagnosis and the disease course of Crohn's disease (CD) and ulcerative colitis (UC) show remarkable heterogeneity across patients. In recent population-based epidemiological and referral cohort studies, the evolution of disease phenotype of CD and UC varied significantly. Most CD and severe UC patients still requires hospitalization or surgery/colectomy during follow-up. A change in the natural history of IBD with improved outcomes in parallel with tailored positioning of aggressive immunomodulator and biological therapy has been suspected according to the recently available literature...
March 28, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28369422/ileal-pouch-anal-anastomosis-for-dysplasia-or-cancer-complicating-inflammatory-bowel-disease-is-total-mesorectal-excision-always-mandatory-an-analysis-of-36-consecutive-patients
#14
Chloé Coton, Léon Maggiori, Diane Mège, Clotilde Naudot, Justine Prost À la Denise, Yves Panis
Background & Aim: The extent of lymph node harvesting during surgery for colorectal neoplasm (dysplasia and/or cancer) complicating inflammatory bowel disease (IBD) is the matter of debate. This study aimed to assess the risk of invasive rectal cancer in patients undergoing ileal pouch-anal anastomosis (IPAA) for colonic neoplasm complicating IBD, and thus to clarify if a systematic total mesorectal excision (TME) should be systematically performed or not in those patients. Methods: From 1998 to 2015, all patients who underwent IPAA for colorectal neoplasm complicating IBD were included...
March 22, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28365486/improved-long-term-outcomes-of-patients-with-inflammatory-bowel-disease-receiving-proactive-compared-with-reactive-monitoring-of-serum-concentrations-of-infliximab
#15
Konstantinos Papamichael, Karen A Chachu, Ravy Vajravelu, Byron P Vaughn, Josephine Ni, Mark T Osterman, Adam S Cheifetz
BACKGROUND & AIMS: Monitoring serum concentrations of tumor necrosis factor antagonists in patients receiving these drugs as treatment for inflammatory bowel disease (IBD), also called therapeutic drug monitoring, is performed either after patient loss of response (reactive drug monitoring) or in patients in clinical remission whose drug has been titrated to a target concentration (proactive drug monitoring). We compared long-term outcomes of patients with IBD undergoing proactive vs reactive monitoring of serum concentrations of infliximab...
March 29, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28361220/disease-severity-and-treatment-requirements-in-familial-inflammatory-bowel-disease
#16
María Pilar Ballester, David Martí, Joan Tosca, Marta Maia Bosca-Watts, Ana Sanahuja, Pablo Navarro, Isabel Pascual, Rosario Antón, Francisco Mora, Miguel Mínguez
PURPOSE: Several studies demonstrate an increased prevalence and concordance of inflammatory bowel disease among the relatives of patients. Other studies suggest that genetic influence is over-estimated. The aims of this study are to evaluate the phenotypic expression and the treatment requirements in familial inflammatory bowel disease, to study the relationship between number of relatives and degree of kinship with disease severity and to quantify the impact of family aggregation compared to other environmental factors...
March 31, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28359559/preoperative-anemia-and-outcomes-in-patients-undergoing-surgery-for-inflammatory-bowel-disease
#17
M Michailidou, V N Nfonsam
BACKGROUND: Anemia is the most common extraintestinal manifestation in patients with inflammatory bowel disease (IBD), and has been linked to severity of the disease. The aim of the study was to assess the impact of anemia on postoperative outcomes in patients with IBD. METHODS: We retrospectively reviewed patients with IBD from the NSQIP database over an 8-year period. Patients were grouped based on the presence of anemia. The impact of anemia on postoperative morbidity, mortality and length of stay was assessed...
March 14, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28350740/prevalence-of-hepatitis-b-and-c-and-factors-for-infection-and-nonimmune-in-inflammatory-bowel-disease-patients-in-china
#18
Dafan Chen, Shengzheng Luo, Qiwen Ben, Lungen Lu, Xinjian Wan, Jianjiong Wu
OBJECTIVE: The aims of this study were to investigate the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in inflammatory bowel disease (IBD) patients and the risk factors related to the infection and nonimmune status. METHODS: A retrospective study was carried out at two clinical centers. The prevalence of viral markers and risk factors related to HBV and HCV infection and nonimmune status were analyzed in IBD patients. Age-matched and sex-matched healthy individuals were recruited as the controls...
May 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28348756/amoeboma-in-a-saudi-resident-a-case-report
#19
Sanaa Al Rehily, Reham Kaki, Fahad Al Ghamdi, Dalia El-Hossary
INTRODUCTION: Amoebiasis is the third most frequent cause of mortality after malaria and schistosomiasis. In developed countries, amebiasis is also seen in migrants who have travelled to endemic areas. The factors responsible for its progression from intestinal amebiasis to an amebic liver abscess are not fully understood. CASE PRESENTATION: A 54-year-old man presented with abdominal pain, fever and diarrhoea. Laparotomy confirmed an inflammatory mass involving the right colon, and he underwent a right hemicolectomy...
June 2016: JMM Case Reports
https://www.readbyqxmd.com/read/28337230/health-related-quality-of-life-assessment-among-patients-with-inflammatory-bowel-diseases-after-surgery-review
#20
REVIEW
Grażyna Bączyk, Dorota Formanowicz, Łukasz Gmerek, Piotr Krokowicz
Aim of the work was to review systematically the published literature addressing whether quality of life (QoL) and health-related QoL (HRQoL) are influenced by surgery among patients with inflammatory bowel disease (IBD). Electronic databases and published articles were searched to identify relevant studies published in the years 1990-2015. Then, a multistep selection was undertaken to identify articles that met specific selection criteria, such us specific key-words (IBD, HRQoL, ulcerative colitis (UC), Crohn's disease (CD), and surgery), and the population was assessed (studies concerning patients < 18 years old were excluded)...
2017: Przegla̜d Gastroenterologiczny
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