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https://www.readbyqxmd.com/read/28092898/florid-erythrophagocytosis-by-neutrophils-in-peripheral-blood
#1
Weijie Li, Naresh Reddivalla
No abstract text is available yet for this article.
August 4, 2016: Blood
https://www.readbyqxmd.com/read/28087963/vitamin-d-deficiency-rickets-even-with-abundant-sunlight-a-case-to-highlight-emerging-problem
#2
T H Ting, A S Devnani
We describe a case of vitamin-D-deficiency rickets in a young child to highlight its existence in Malaysia where sunlight is abundant throughout the year. The child presented with deformity of both legs. He came from an educated urban family but remained indoors most of the time. Radiographs of knees and wrists showed changes of florid rickets. Low serum 25-hydoxyvitamin-D, high parathyroid hormone, normal serum phosphate and calcium levels, and normal renal function clinched the diagnosis of vitamin-D-deficiency rickets...
December 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28087919/presumptive-spontaneous-lysosomal-storage-like-disease-in-a-crl-cd1-icr-mouse
#3
Krista M
A clinically unremarkable 4.5-mo-old female Crl:CD1(ICR) VAF/Elite mouse was euthanized for scheduled sentinel processing.Gross necropsy findings included significant hepatosplenomegaly and visceral lymphadenomegaly, resulting in a preliminarygross diagnosis of lymphoma. Histology revealed florid accumulations of large, 'foamy' macrophages present in the bone marrow, small intestines, and viscera including liver, spleen, lymph nodes, thymus, uterus, and ovaries. The cytoplasm of these cells was abundant, stained pale blue with Wright-Giemsa and was periodic acid-Schiff positive...
January 13, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28071741/loss-of-coupling-distinguishes-gjb1-mutations-associated-with-cns-manifestations-of-cmt1x-from-those-without-cns-manifestations
#4
Charles K Abrams, Mikhail Goman, Sarah Wong, Steven S Scherer, Kleopas A Kleopa, Alejandro Peinado, Mona M Freidin
CMT1X, an X-linked inherited neuropathy, is caused by mutations in GJB1, which codes for Cx32, a gap junction protein expressed by Schwann cells and oligodendrocytes. Many GJB1 mutations cause central nervous system (CNS) abnormality in males, including stable subclinical signs and, less often, short-duration episodes characterized by motor difficulties and altered consciousness. However, some mutations have no apparent CNS effects. What distinguishes mutations with and without CNS manifestations has been unclear...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28045749/histologic-assessment-of-lichenoid-dermatitis-observed-in-patients-with-advanced-malignancies-on-antiprogramed-cell-death-1-anti-pd-1-therapy-with-or-without-ipilimumab
#5
Shaun Chou, Shelley Ji Eun Hwang, Giuliana Carlos, Deepal Wakade, Pablo Fernandez-Penas
Lichenoid drug reaction is a common adverse reaction in patients taking immune-modulatory agents such as antiprogramed cell death (PD-1) and cytotoxic T lymphocyte antigen-4 agents. The authors describe the clinical and histologic features of lichenoid drug reaction in 20 biopsies from 15 patients on anti-PD-1 agents and 9 biopsies from 7 patients on anti-PD-1 plus ipilimumab therapy. Clinically, all except 2 patients presented with discrete, violaceous exanthematous papules to plaques. The lichenoid inflammation in the majority (18 of 29 biopsies) was florid although histology was quite heterogeneous...
January 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28024511/-clinico-pathologic-characteristics-of-adult-patients-with-atypical-infectious-mononucleosis
#6
Ya-Ping Yu, Ping Song, Zhi-Ming An, Xiao-Gang Zhou, Feng Li, Li-Ping Wang, Jian-Gang Mei, Yong-Ping Zhai
OBJECTIVE: To investigate the clinicopathologic characteristics of adult patients with atypical infectious mononucleosis(IM). METHODS: From January 2003 to December 2013, a total of 5 cases of atypical IM misdiagnosed as lymphoma were selected, and the clinico-pathological characteristics and efficacy of treatment were analyzed. Biopsy of lymph node or tonsil was performed to evaluate the possibility of lymphoma. Peripheral blood EBV antibody and EBV-DNA were examined by ELISA and real-time fluorescence quantitative PCR, respectively...
December 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28009405/fulminant-idiopathic-intracranial-hypertension-and-venous-stasis-retinopathy-resulting-in-severe-bilateral-visual-impairment
#7
Alexander Voldman, Breanna Durbin, John Nguyen, Brian Ellis, Monique Leys
PURPOSE: To report a complicated case of fulminant idiopathic intracranial hypertension and concomitant venous stasis retinopathy leading to postpapilledema optic atrophy. METHODS: Case report. RESULTS: A 34-year-old morbidly obese woman with a history of idiopathic intracranial hypertension (IIH) presented with a 1-month history of bilateral vision loss, diplopia, and left eye pain after being lost to follow-up for 6 years. Fundus examination revealed florid papilledema with venous tortuosity bilaterally...
December 6, 2016: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28005783/florid-cemento-osseous-dysplasia-simultaneous-the-chronic-suppurative-osteomyelitis-in-mandible
#8
Mateus Barros Cavalcante, Amanda Laísa de Oliveira Lima, Marcus Antônio Brêda Júnior, Milkle Bruno Pessoa Santos
INTRODUCTION: The florid cemento-osseous dysplasia is an uncommon condition nonneoplastic, of unknown cause with higher prevalence in melanodermic women, limited the maxillary bones, is characterized by the presence of dispersed and diffuse radiopaque calcifications, constituted of bone and dense cemento; however, when the bone is infected it induces the suppuration and formation of osseous sequestra, thus resulting in an osteomyelitis frame. CLINICAL REPORT: The patient was attended in a Dental Specialties Center in the state of Alagoas, Brazil, presenting on clinical examination edema and extra oral fistula with pus drainage in hemiface submandibular of the right side...
November 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28002343/florid-reactive-periostitis-in-the-fifth-phalange-of-a-professional-boxer-a-case-report
#9
Yuji Tomori, Ryuji Ohashi, Zenya Naito, Mitsuhiko Nanno, Shinro Takai
RATIONALE: Florid reactive periostitis is a rare, benign bone and chondrogenic lesion that develops most frequently in the phalanges of the hands. Although the definitive cause of florid reactive periostitis is unknown, the major inciting factor is generally considered to be trauma, including repetitive minor trauma. PATIENT CONCERNS: We present a case of florid reactive periostitis affecting two contiguous phalangeal bones of the left fifth phalange of a 23-year-old male professional boxer...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27992143/kompressionstherapie-versorgungspraxis-informationsstand-von-patienten-mit-ulcus-cruris-venosum
#10
Kerstin Protz, Kristina Heyer, Joachim Dissemond, Barbara Temme, Karl-Christian Münter, Ida Verheyen-Cronau, Katharina Klose, Carsten Hampel-Kalthoff, Matthias Augustin
HINTERGRUND UND ZIELE: Eine Säule der kausalen Therapie bei Patienten mit Ulcus cruris venosum ist die Kompressionstherapie. Sie unterstützt die Abheilung, reduziert Schmerzen und Rezidive und steigert die Lebensqualität. Bislang existieren kaum wissenschaftliche Daten zu dem Versorgungsstand und fachspezifischem Wissen von Patienten mit Ulcus cruris venosum. PATIENTEN UND METHODIK: Standardisierte Fragebögen wurden bundesweit in 55 Pflegediensten, 32 Arztpraxen, vier Wundzentren und -sprechstunden sowie einem Pflegetherapiestützpunkt von Patienten mit Ulcus cruris venosum bei Erstvorstellung anonym ausgefüllt...
December 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27992134/compression-therapy-current-practice-of-care-level-of-knowledge-in-patients-with-venous-leg-ulcers
#11
Kerstin Protz, Kristina Heyer, Joachim Dissemond, Barbara Temme, Karl-Christian Münter, Ida Verheyen-Cronau, Katharina Klose, Carsten Hampel-Kalthoff, Matthias Augustin
BACKGROUND AND OBJECTIVES: Compression therapy is a mainstay in the causal treatment of patients with venous leg ulcers. It facilitates healing, reduces pain and recurrences, and increases quality of life. Up until now, there is a scarcity of scientific data with respect to the level of care and the specific knowledge of patients with venous leg ulcers. PATIENTS AND METHODS: At first presentation, patients with venous leg ulcers anonymously answered a standardized questionnaire...
December 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27966012/-surface-replacement-of-proximal-interphalangeal-joints-using-capflex-pip
#12
S F Schindele, A Altwegg, S Hensler
OBJECTIVE OF SURGERY: The cementless implantation of the surface replacement CapFlex-PIP enables pain relief, preservation of motion, improves lateral stability and corrects axis deviation in proximal interphalangeal (PIP) joints of patients with primary and secondary PIP osteoarthritis. INDICATIONS: Painful PIP joints as a result of degenerative or posttraumatic osteoarthritis with restriction of motion. Secondary inflammatory destruction of PIP joints in rheumatoid arthritis with low inflammatory activity and good bone conditions...
December 13, 2016: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/27913482/update-on-the-diagnosis-and-management-of-paroxysmal-nocturnal-hemoglobinuria
#13
Charles J Parker
Once suspected, the diagnosis of paroxysmal nocturnal hemoglobinuria (PNH) is straightforward when flow cytometric analysis of the peripheral blood reveals a population of glycosyl phosphatidylinositol anchor protein-deficient cells. But PNH is clinically heterogeneous, with some patients having a disease process characterized by florid intravascular, complement-mediated hemolysis, whereas in others, bone marrow failure dominates the clinical picture with modest or even no evidence of hemolysis observed. The clinical heterogeneity is due to the close, though incompletely understood, relationship between PNH and immune-mediated bone marrow failure, and that PNH is an acquired, nonmalignant clonal disease of the hematopoietic stem cells...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27884577/low-pressure-pericardial-tamponade-case-report-and-review-of-the-literature
#14
Brooks M Walsh, Lauren A Tobias
BACKGROUND: Focused cardiac ultrasound (FoCUS) is accurate for determining the presence of a pericardial effusion. Using FoCUS to evaluate for pericardial tamponade, however, is more involved. Many experts teach that tamponade is unlikely if the inferior vena cava (IVC) shows respiratory variation and is not distended. CASE REPORT: A 53-year-old woman presented to the emergency department (ED) with severe orthostatic hypotension, exertional dyspnea, and hypoxia...
November 21, 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27857465/unusual-imaging-presentation-of-infantile-atypical-kawasaki-disease
#15
Nishith Kumar, Mahesh Kumar Mittal, Mukul Sinha, Arpita Gupta, Brij Bhushan Thukral
Kawasaki disease is a systemic medium vessel vasculitis of unknown etiology affecting children under 5 years of age. There are no specific diagnostic tests, and thus, the diagnosis of the disease is primarily made on the basis of clinical criteria. Unusual presentations of Kawasaki disease have been variably reported from different parts of the world. However, presentation of the disease in the form of peripheral thromboembolism and florid non-coronary aneurysms has rarely been described This report describes the imaging findings in infantile atypical Kawasaki disease with aneurysms of multiple medium-sized arteries, including coronary arteries, emphasizing the detection of clinically silent aneurysms in the disease...
July 2016: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/27842573/pseudocarcinomatous-hyperplasia-of-the-fallopian-tube-mimicking-tubal-cancer-a-radiological-and-pathological-diagnostic-challenge
#16
Nam Kyung Lee, Kyung Un Choi, Ga Jin Han, Byung Su Kwon, Yong Jung Song, Dong Soo Suh, Ki Hyung Kim
BACKGROUND: Pseudocarcinomatous hyperplasia of the fallopian tube is a rare, benign disease characterized by florid epithelial hyperplasia. CASE PRESENTATION: The authors present the history and details of a 22-year-old woman with bilateral pelvic masses and a highly elevated serum CA-125 level (1,056 U/ml). Ultrasonography and magnetic resonance imaging (MRI) of the pelvis showed bilateral adnexal complex cystic masses with a fusiform or sausage-like shape. Contrast-enhanced fat-suppressed T1-weighted images showed enhancement of papillary projections of the right adnexal mass and enhancement of an irregular thick wall on the left adnexal mass, suggestive of tubal cancer...
November 14, 2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27831531/subareolar-sclerosing-ductal-hyperplasia
#17
Esther Cheng, Timothy M D'Alfonso, Maria Arafah, Rebecca Marrero Rolon, Paula S Ginter, Syed A Hoda
Subareolar sclerosing duct hyperplasia (SSDH) remains to be fully characterized nearly 20 years after initial description. Thirty-five SSDH cases diagnosed over a 16-year period (January 2000 to December 2015) were reviewed. All patients were female (mean age = 59 years, range = 18-80) who had presented with a unilateral solitary lesion (left 22, right 13) with a mean size of 1.3 cm (range = 0.4-3.0 cm), and showed florid and papillary epithelial hyperplasia with dense sclerosis without involvement of nipple or areolar epidermis...
February 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27825664/-florid-osseous-dysplasia-management-of-a-symptomatic-case
#18
M Maccotta, L Radoï
INTRODUCTION: Florid osseous dysplasia is a rare and benign fibro-osseous pathology, in which bone is replaced by fibrous tissue and metaplastic bone. It can remain asymptomatic for a long time and is most often discovered incidentally during a radiological examination. Sometimes, patients are seen because of an infectious complication. OBSERVATION: An edentulous 62 years-old woman was referred for a painful mandibular swelling preventing insertion of her removable denture...
December 2016: Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale
https://www.readbyqxmd.com/read/27797809/timing-and-significance-of-pathological-features-in-c9orf72-expansion-associated-frontotemporal-dementia
#19
Sarat C Vatsavayai, Soo Jin Yoon, Raquel C Gardner, Tania F Gendron, Jose Norberto S Vargas, Andrew Trujillo, Mochtar Pribadi, Joanna J Phillips, Stephanie E Gaus, John D Hixson, Paul A Garcia, Gil D Rabinovici, Giovanni Coppola, Daniel H Geschwind, Leonard Petrucelli, Bruce L Miller, William W Seeley
SEE SCABER AND TALBOT DOI101093/AWW264 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: A GGGGCC repeat expansion in C9orf72 leads to frontotemporal dementia and/or amyotrophic lateral sclerosis. Diverse pathological features have been identified, and their disease relevance remains much debated. Here, we describe two illuminating patients with frontotemporal dementia due to the C9orf72 repeat expansion. Case 1 was a 65-year-old female with behavioural variant frontotemporal dementia accompanied by focal degeneration in subgenual anterior cingulate cortex, amygdala, and medial pulvinar thalamus...
December 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/27776522/inositol-1-4-5-trisphosphate-receptor-type-1-autoantibodies-in-paraneoplastic-and-non-paraneoplastic-peripheral-neuropathy
#20
Sven Jarius, Marius Ringelstein, Jürgen Haas, Irina I Serysheva, Lars Komorowski, Kai Fechner, Klaus-Peter Wandinger, Philipp Albrecht, Harald Hefter, Andreas Moser, Eva Neuen-Jacob, Hans-Peter Hartung, Brigitte Wildemann, Orhan Aktas
BACKGROUND: Recently, we described a novel autoantibody, anti-Sj/ITPR1-IgG, that targets the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in patients with cerebellar ataxia. However, ITPR1 is expressed not only by Purkinje cells but also in the anterior horn of the spinal cord, in the substantia gelatinosa and in the motor, sensory (including the dorsal root ganglia) and autonomic peripheral nervous system, suggesting that the clinical spectrum associated with autoimmunity to ITPR1 may be broader than initially thought...
October 24, 2016: Journal of Neuroinflammation
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