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https://www.readbyqxmd.com/read/28655029/breast-cancer-screening-with-mammography-plus-ultrasonography-or-magnetic-resonance-imaging-in-women-50-years-or-younger-at-diagnosis-and-treated-with-breast-conservation-therapy
#1
Nariya Cho, Wonshik Han, Boo-Kyung Han, Min Sun Bae, Eun Sook Ko, Seok Jin Nam, Eun Young Chae, Jong Won Lee, Sung Hun Kim, Bong Joo Kang, Byung Joo Song, Eun-Kyung Kim, Hee Jung Moon, Seung Il Kim, Sun Mi Kim, Eunyoung Kang, Yunhee Choi, Hak Hee Kim, Woo Kyung Moon
Importance: Younger women (aged ≤50 years) who underwent breast conservation therapy may benefit from breast magnetic resonance imaging (MRI) screening as an adjunct to mammography. Objective: To prospectively determine the cancer yield and tumor characteristics of combined mammography with MRI or ultrasonography screening in women who underwent breast conservation therapy for breast cancers and who were 50 years or younger at initial diagnosis. Design, Setting, and Participants: This multicenter, prospective, nonrandomized study was conducted from December 1, 2010, to January 31, 2016, at 6 academic institutions...
June 22, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28654940/consonant-acoustics-in-parkinson-s-disease-and-multiple-sclerosis-comparison-of-clear-and-loud-speaking-conditions
#2
Kris Tjaden, Vincent Martel-Sauvageau
Purpose: The impact of clear speech or an increased vocal intensity on consonant spectra was investigated for speakers with mild dysarthria secondary to multiple sclerosis or Parkinson's disease and healthy controls. Method: Sentences were read in habitual, clear, and loud conditions. Spectral moment coefficients were obtained for word-initial and word-medial /s/, /ʃ/, /t/, and /k/. Global production differences among conditions were confirmed with measures of vocal intensity and articulation rate...
June 22, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28654799/neurobehavioral-consequences-of-continuous-spike-and-waves-during-slow-sleep-csws-in-a-pediatric-population-a-pattern-of-developmental-hindrance
#3
Valentina De Giorgis, Melissa Filippini, Joyce Ann Macasaet, Silvia Masnada, Pierangelo Veggiotti
INTRODUCTION: Continuous spike and waves during slow sleep (CSWS) is a typical EEG pattern defined as diffuse, bilateral and recently also unilateral or focal localization spike-wave occurring in slow sleep or non-rapid eye movement sleep. Literature results so far point out a progressive deterioration and decline of intellectual functioning in CSWS patients, i.e. a loss of previously normally acquired skills, as well as persistent neurobehavioral disorders, beyond seizure and EEG control...
June 24, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28654612/evidence-based-medicine-breast-augmentation
#4
Michael R Schwartz
LEARNING OBJECTIVES: After reading this article, the participant should be able to: 1. Understand the key decisions in patient evaluation for cosmetic breast augmentation. 2. Cite key decisions in preoperative planning. 3. Discuss the risks and complications, and key patient education points in breast augmentation. SUMMARY: Breast augmentation remains one of the most popular procedures in plastic surgery. The integral information necessary for proper patient selection, preoperative assessment, and surgical approaches are discussed...
July 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28653986/3d-qsar-and-molecular-docking-studies-on-the-tcpmca1-mediated-detoxification-of-scopoletin-and-coumarin-derivatives
#5
Qiu-Li Hou, Jin-Xiang Luo, Bing-Chuan Zhang, Gao-Fei Jiang, Wei Ding, Yong-Qiang Zhang
The carmine spider mite, Tetranychus cinnabarinus (Boisduval), is an economically important agricultural pest that is difficult to prevent and control. Scopoletin is a botanical coumarin derivative that targets Ca(2+)-ATPase to exert a strong acaricidal effect on carmine spider mites. In this study, the full-length cDNA sequence of a plasma membrane Ca(2+)-ATPase 1 gene (TcPMCA1) was cloned. The sequence contains an open reading frame of 3750 bp and encodes a putative protein of 1249 amino acids. The effects of scopoletin on TcPMCA1 expression were investigated...
June 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28652931/piwi1-is-essential-for-gametogenesis-in-mollusk-chlamys-farreri
#6
Xiaoshi Ma, Aichang Ji, Zhifeng Zhang, Dandan Yang, Shaoshuai Liang, Yuhan Wang, Zhenkui Qin
Piwi (P-element induced wimpy testis) is an important gene involved in stem cell maintenance and gametogenesis in vertebrates. However, in most invertebrates, especially mollusks, the function of Piwi during gametogenesis remains largely unclear. To further understand the function of Piwi during gametogenesis, full-length cDNA of Piwi1 from scallop Chlamys farreri (Cf-Piwi1) was characterized, which consisted of a 2,637 bp open reading frame encoding an 878-amino acid protein. Cf-Piwi1 mRNA was mainly localized in the spermatogonia, spermatocytes, oogonia, oocytes of early development and intra-gonadal somatic cells...
2017: PeerJ
https://www.readbyqxmd.com/read/28652370/small-mitochondrial-arf-smarf-protein-corrects-p53-independent-developmental-defects-of-arf-tumor-suppressor-deficient-mice
#7
Jolieke G van Oosterwijk, Chunliang Li, Xue Yang, Joseph T Opferman, Charles J Sherr
The mouse p19(Arf) (human p14(ARF)) tumor suppressor protein, encoded in part from an alternative reading frame of the Ink4a (Cdkn2a) gene, inhibits the Mdm2 E3 ubiquitin ligase to activate p53. Arf is not expressed in most normal tissues of young mice but is induced by high thresholds of aberrant hyperproliferative signals, thereby activating p53 in incipient tumor cells that have experienced oncogene activation. The single Arf mRNA encodes two distinct polypeptides, including full-length p19(Arf) and N-terminally truncated and unstable p15(smArf) ("small mitochondrial Arf") initiated from an internal in-frame AUG codon specifying methionine-45...
June 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28651927/doxorubicin-plus-evofosfamide-versus-doxorubicin-alone-in-locally-advanced-unresectable-or-metastatic-soft-tissue-sarcoma-th-cr-406-sarc021-an-international-multicentre-open-label-randomised-phase-3-trial
#8
William D Tap, Zsuzsanna Papai, Brian A Van Tine, Steven Attia, Kristen N Ganjoo, Robin L Jones, Scott Schuetze, Damon Reed, Sant P Chawla, Richard F Riedel, Anders Krarup-Hansen, Maud Toulmonde, Isabelle Ray-Coquard, Peter Hohenberger, Giovanni Grignani, Lee D Cranmer, Scott Okuno, Mark Agulnik, William Read, Christopher W Ryan, Thierry Alcindor, Xavier F Garcia Del Muro, G Thomas Budd, Hussein Tawbi, Tillman Pearce, Stew Kroll, Denise K Reinke, Patrick Schöffski
BACKGROUND: Evofosfamide is a hypoxia-activated prodrug of bromo-isophosphoramide mustard. We aimed to assess the benefit of adding evofosfamide to doxorubicin as first-line therapy for advanced soft-tissue sarcomas. METHODS: We did this international, open-label, randomised, phase 3, multicentre trial (TH CR-406/SARC021) at 81 academic or community investigational sites in 13 countries. Eligible patients were aged 15 years or older with a diagnosis of an advanced unresectable or metastatic soft-tissue sarcoma, of intermediate or high grade, for which no standard curative therapy was available, an Eastern Cooperative Oncology Group performance status of 0-1, and measurable disease by Response Evaluation Criteria in Solid Tumors version 1...
June 23, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28651801/physician-attitudes-toward-the-first-pediatric-appropriate-use-criteria-and-engagement-with-educational-intervention-to-improve-the-appropriateness-of-outpatient-echocardiography
#9
Ritu Sachdeva, Michael S Kelleman, Courtney E McCracken, Robert M Campbell, Wyman W Lai, Leo Lopez, Kenan W D Stern, Elizabeth Welch, Pamela S Douglas
BACKGROUND: A survey of pediatric cardiologists who participated in the Pediatric Appropriate Use of Echocardiography study was conducted to assess attitudes toward appropriate use criteria (AUC) and the relationship between perceptions of usefulness of a multifaceted educational intervention (EI) and the appropriateness of transthoracic echocardiography (TTE). METHODS: Self-reported helpfulness and impact of a four-component EI (feedback of personal appropriateness data before EI, lecture, self-assignment of AUC indications, and monthly feedback) was surveyed...
June 23, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28651096/predicting-actions-from-subtle-preparatory-movements
#10
Maryam Vaziri-Pashkam, Sarah Cormiea, Ken Nakayama
To study how people anticipate others' actions, we designed a competitive reaching task. Subjects faced each other separated by a Plexiglas screen and their finger movements in 3D space were recorded with sensors. The first subject (Attacker) was instructed to touch one of two horizontally arranged targets on the screen. The other subject (Blocker) touched the same target as quickly as possible. Average finger reaction times (fRTs) were fast, much faster than reactions to a dot moving on the screen in the same manner as the Attacker's finger...
June 23, 2017: Cognition
https://www.readbyqxmd.com/read/28650924/comparison-of-approaches-for-notification-and-authorization-in-pragmatic-clinical-research-evaluating-commonly-used-medical-practices
#11
Kevin P Weinfurt, Juli M Bollinger, Kathleen M Brelsford, Martina Bresciani, Zachary Lampron, Li Lin, Rachel J Topazian, Jeremy Sugarman
BACKGROUND: For pragmatic clinical research comparing commonly used treatments, questions exist about if and how to notify participants about it and secure their authorization for participation. OBJECTIVE: To determine how patients react when they seek clinical care and encounter one of several different pragmatic clinical research studies. RESEARCH DESIGN: In an online survey using a between-subjects experimental design, respondents read and responded to 1 of 24 hypothetical research scenarios reflecting different types of studies and approaches to notification and authorization (eg, general notification, oral consent, written consent)...
June 23, 2017: Medical Care
https://www.readbyqxmd.com/read/28649424/an-alanine-expanded-pabpn1-causes-increased-utilization-of-intronic-polyadenylation-sites
#12
Tooba Abbassi-Daloii, Soheil Yousefi, Eleonora de Klerk, Laurens Grossouw, Muhammad Riaz, Peter A C 't Hoen, Vered Raz
In eukaryote genomes, the polyadenylation site marks termination of mature RNA transcripts by a poly-adenine tail. The polyadenylation site is recognized by a dynamic protein complex, among which the poly-adenine-binding protein nuclear1 plays a key role. Reduced poly-adenine-binding protein nuclear1 levels are found in aged muscles and are even lower in oculopharyngeal muscular dystrophy patients. Oculopharyngeal muscular dystrophy is a rare, late onset autosomal dominant myopathy, and is caused by an alanine expansion mutation in poly-adenine-binding protein nuclear1...
2017: NPJ Aging and Mechanisms of Disease
https://www.readbyqxmd.com/read/28649169/form-overrides-meaning-when-bilinguals-monitor-for-errors
#13
Iva Ivanova, Victor S Ferreira, Tamar H Gollan
Bilinguals rarely produce unintended language switches, which may in part be because switches are detected and corrected by an internal monitor. But are language switches easier or harder to detect than within-language semantic errors? To approximate internal monitoring, bilinguals listened (Experiment 1) or read aloud (Experiment 2) stories, and detected language switches (translation equivalents or semantically unrelated to expected words) and within-language errors (semantically related or unrelated to expected words)...
June 2017: Journal of Memory and Language
https://www.readbyqxmd.com/read/28648286/yeast-diversity-during-the-fermentation-of-andean-chicha-a-comparison-of-high-throughput-sequencing-and-culture-dependent-approaches
#14
Lucía M Mendoza, Alexander Neef, Graciela Vignolo, Carmela Belloch
Diversity and dynamics of yeasts associated with the fermentation of Argentinian maize-based beverage chicha was investigated. Samples taken at different stages from two chicha productions were analyzed by culture-dependent and culture-independent methods. Five hundred and ninety six yeasts were isolated by classical microbiological methods and 16 species identified by RFLPs and sequencing of D1/D2 26S rRNA gene. Genetic typing of isolates from the dominant species, Saccharomyces cerevisiae, by PCR of delta elements revealed up to 42 different patterns...
October 2017: Food Microbiology
https://www.readbyqxmd.com/read/28647830/the-comprehension-of-syntactic-and-affective-prosody-by-adults-with-autism-spectrum-disorder-without-accompanying-cognitive-deficits
#15
Maria Martzoukou, Despina Papadopoulou, Mary-Helen Kosmidis
The present study investigates the comprehension of syntactic and affective prosody in adults with autism spectrum disorder without accompanying cognitive deficits (ASD w/o cognitive deficits) as well as age-, education- and gender-matched unimpaired adults, while processing orally presented sentences. Two experiments were conducted: (a) an on-line sentence completion task containing local subject/object ambiguities and (b) an affective prosody task exploring the comprehension of six emotions. The syntactic prosody task revealed that the experimental group performed similar to the control group on the fillers and the object condition...
June 24, 2017: Journal of Psycholinguistic Research
https://www.readbyqxmd.com/read/28647817/molecular-characterization-of-the-cd79a-and-cd79b-and-its-role-against-aeromonas-hydrophila-infection-in-chinese-sucker-myxocyprinus-asiaticus
#16
Huan Li, Yujin Li, Xiaoping Zhang, Yafeng Wang, Wufeng Zhang, Xia Wu, Zhijian Wang
CD79a and CD79b heterodimers are the important signaling components of B cell receptor (BCR) complex which plays a crucial role in B cell development and antibody production. In the present study, CD79a and CD79b homologues from Chinese sucker (Myxocyprinus asiaticus), namely MaCD79a and MaCD79b, were identified and their expression at early developmental stages and under constitutive and stimulated conditions were investigated. The cDNA sequences for MaCD79a and MaCD79b contained open reading frame of 678 and 636 bp in length for 225 and 211 amino acid residues, respectively...
June 25, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28647744/effectiveness-of-supported-self-help-in-recurrent-depression-a-randomized-controlled-trial-in-primary-care
#17
Karolien E M Biesheuvel-Leliefeld, Sandra M A Dijkstra-Kersten, Digna J F van Schaik, Harm W J van Marwijk, Filip Smit, Henriette E van der Horst, Claudi L H Bockting
BACKGROUND: The burden and economic consequences of depression are high, mostly due to its recurrent nature. Due to current budget and time restraints, a preventive, low- cost, accessible minimal intervention is much needed. In this study, we evaluated the effectiveness of a supported self-help preventive cognitive therapy (S-PCT) added to treatment as usual (TAU) in primary care, compared to TAU alone. METHODS: We conducted a randomized controlled trial among 248 patients with a history of depression, currently in full or partial remission or recovery...
June 24, 2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28647560/transcript-expression-bias-of-phosphatidylethanolamine-binding-protein-gene-in-bumblebee-bombus-lantschouensis-hymenoptera-apidae
#18
Jie Dong, Lei Han, Ye Wang, Jiaxing Huang, Jie Wu
The phosphatidylethanolamine-binding protein (PEBP) family is a highly conserved group of proteins found in a wide range of organism. It plays an important role in innate immunity of insects. Little is known on the expression characteristic and function of PEBP in bees. In the current study, we cloned the pebp gene and investigated its expression profiles at different developmental stages and reproductive status from bumblebee, Bombus lantschouensis (Vogt), which is one of the most abundant pollinators for wild plants and crops in Northern China...
June 21, 2017: Gene
https://www.readbyqxmd.com/read/28646994/reading-the-tree-leaves-how-to-enrich-clinical-trials-of-diabetic-kidney-disease
#19
Helen C Looker, Robert G Nelson
Most participants selected for clinical trials of renoprotective drugs do not reach approved endpoints; thus, large trials or prolonged follow-up are needed to achieve adequate statistical power. Yamanouchi et al. used a classification and regression trees analysis to enrich enrollment criterion for patients at the highest risk of reaching these outcomes. Their findings suggest a greater role for newly identified biomarkers of diabetic kidney disease in the selection of participants for clinical trials.
July 2017: Kidney International
https://www.readbyqxmd.com/read/28646750/phonological-and-orthographic-coding-in-deaf-skilled-readers
#20
Noemi Fariña, Jon Andoni Duñabeitia, Manuel Carreiras
Written language is very important in daily life. However, most deaf people do not achieve good reading levels compared to their hearing peers. Previous research has mainly focused on their difficulties when reading in a language with an opaque orthography such as English. In the present study, we investigated visual word recognition of deaf adult skilled readers while reading in Spanish, a language with a transparent orthography, for which obligatory phonological mediation has been claimed. Experiment 1 showed a pseudohomophone inhibitory effect in hearing but not in deaf people...
June 21, 2017: Cognition
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