Mariane Le Fur, Brianna F Moon, Iris Y Zhou, Samantha Zygmont, Avery Boice, Nicholas J Rotile, Ilknur Ay, Pamela Pantazopoulos, Adam S Feldman, Ivy A Rosales, Ira Doressa Anne L How, David Izquierdo-Garcia, Lida P Hariri, Andrei V Astashkin, Brian P Jackson, Peter Caravan
Background Gadolinium retention has been observed in organs of patients with normal renal function; however, the biodistribution and speciation of residual gadolinium is not well understood. Purpose To compare the pharmacokinetics, distribution, and speciation of four gadolinium-based contrast agents (GBCAs) in healthy rats using MRI, mass spectrometry, elemental imaging, and electron paramagnetic resonance (EPR) spectroscopy. Materials and Methods In this prospective animal study performed between November 2021 and September 2022, 32 rats received a dose of gadoterate, gadoteridol, gadobutrol, or gadobenate (2...
October 2023: Radiology