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https://www.readbyqxmd.com/read/28319044/fibroblastic-niches-prime-t-cell-alloimmunity-through-delta-like-notch-ligands
#1
Jooho Chung, Christen L Ebens, Eric Perkey, Vedran Radojcic, Ute Koch, Leonardo Scarpellino, Alexander Tong, Frederick Allen, Sherri Wood, Jiane Feng, Ann Friedman, David Granadier, Ivy T Tran, Qian Chai, Lucas Onder, Minhong Yan, Pavan Reddy, Bruce R Blazar, Alex Y Huang, Todd V Brennan, D Keith Bishop, Burkhard Ludewig, Christian W Siebel, Freddy Radtke, Sanjiv A Luther, Ivan Maillard
Alloimmune T cell responses induce graft-versus-host disease (GVHD), a serious complication of allogeneic bone marrow transplantation (allo-BMT). Although Notch signaling mediated by Delta-like 1/4 (DLL1/4) Notch ligands has emerged as a major regulator of GVHD pathogenesis, little is known about the timing of essential Notch signals and the cellular source of Notch ligands after allo-BMT. Here, we have shown that critical DLL1/4-mediated Notch signals are delivered to donor T cells during a short 48-hour window after transplantation in a mouse allo-BMT model...
March 20, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28318066/three-dimensional-ultrashort-echo-time-cones-t1%C3%AF-3d-ute-cones-t1%C3%AF-imaging
#2
Ya-Jun Ma, Michael Carl, Hongda Shao, Anthony S Tadros, Eric Y Chang, Jiang Du
We report a novel three-dimensional (3D) ultrashort echo time (UTE) sequence employing Cones trajectory and T1ρ preparation (UTE-Cones-T1ρ ) for quantitative T1ρ assessment of short T2 tissues in the musculoskeletal system. A basic 3D UTE-Cones sequence was combined with a spin-locking preparation pulse for T1ρ contrast. A relatively short TR was used to decrease the scan time, which required T1 measurement and compensation using 3D UTE-Cones data acquisitions with variable TRs. Another strategy to reduce the total scan time was to acquire multiple Cones spokes (Nsp ) after each T1ρ preparation and fat saturation...
March 20, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28315462/implications-of-cerebrovascular-atp-binding-cassette-transporter-g1-abcg1-and-apolipoprotein-m-in-cholesterol-transport-at-the-blood-brain-barrier
#3
Alexandra Carmen Kober, Anil Paul Chirackal Manavalan, Carmen Tam-Amersdorfer, Andreas Holmér, Ahmed Saeed, Elham Fanaee Danesh, Martina Zandl, Nicole Maria Albrecher, Ingemar Björkhem, Gerhard M Kostner, Björn Dahlbäck, Ute Panzenboeck
Impaired cholesterol/lipoprotein metabolism is linked to neurodegenerative diseases such as Alzheimer's disease (AD). Cerebral cholesterol homeostasis is maintained by the highly efficient blood-brain barrier (BBB) and flux of the oxysterols 24(S)-hydroxycholesterol and 27-hydroxycholesterol, potent liver-X-receptor (LXR) activators. HDL and their apolipoproteins are crucial for cerebral lipid transfer, and loss of ATP binding cassette transporters (ABC)G1 and G4 results in toxic accumulation of oxysterols in the brain...
March 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28301421/persistence-of-hiv-drug-resistance-among-south-african-children-given-nevirapine-to-prevent-mother-to-child-transmission
#4
Ruth Kanthula, Theresa Rossouw, Ute D Feucht, Gisela Van Dyk, Ingrid A Beck, Rachel Silverman, Scott Olson, Christen Salyer, Sharon Cassol, Lisa M Frenkel
OBJECTIVES: We set out to examine the prevalence and persistence of mutations conferring high-level nonnucleoside-reverse-transcriptase (NNRTI)-resistance in a cohort of HIV-infected children who had failed prophylaxis to prevent mother-to-child-transmission (PMTCT). DESIGN: A prospective observational cohort study at the Pediatric HIV Clinic at Kalafong Provincial Tertiary Hospital in Pretoria, South Africa. METHODS: Children referred for initiation of ART were enrolled from July 2010 through February 2013...
March 15, 2017: AIDS
https://www.readbyqxmd.com/read/28300840/ganetespib-synergizes-with-cyclophosphamide-to-improve-survival-of-mice-with-autochthonous-tumors-in-a-mutant-p53-dependent-manner
#5
Evguenia M Alexandrova, Sulan Xu, Ute M Moll
The DNA-alkylating cytotoxic agent cyclophosphamide (CTX) is commonly used in the clinic to treat hematological malignancies like lymphomas and leukemias as well as solid tumors, but shows dose-dependent potentially life-threatening toxicities and can induce secondary malignancies. Thus, the clinical utility of CTX would be improved if a companion drug could be identified that allows lowering the CTX dose, while maintaining or even increasing its antineoplastic therapeutic efficacy. In mouse models, high-dose CTX (300 mg/kg) is effective in treating T-lymphomas, while low dose (defined here as 100 mg/kg) is ineffective...
March 16, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28296979/feasibility-of-assessing-bone-matrix-and-mineral-properties-in-vivo-by-combined-solid-state-1h-and-31p-mri
#6
Xia Zhao, Hee Kwon Song, Alan C Seifert, Cheng Li, Felix W Wehrli
PURPOSE: To develop and evaluate an integrated imaging protocol for bone water and phosphorus quantification in vivo by solid-state 1H and 31P MRI. MATERIALS AND METHODS: All studies were HIPAA-compliant and were performed with institutional review board approval and written informed consent. Proton (1H) ultra-short echo-time (UTE) and phosphorus (31P) zero echo-time (ZTE) sequences were designed and implemented on a 3 T clinical MR scanner to quantify bone water and mineral in vivo...
2017: PloS One
https://www.readbyqxmd.com/read/28296892/blue-light-induced-accumulation-of-reactive-oxygen-species-is-a-consequence-of-the-drosophila-cryptochrome-photocycle
#7
Louis-David Arthaut, Nathalie Jourdan, Ali Mteyrek, Maria Procopio, Mohamed El-Esawi, Alain d'Harlingue, Pierre-Etienne Bouchet, Jacques Witczak, Thorsten Ritz, André Klarsfeld, Serge Birman, Robert J Usselman, Ute Hoecker, Carlos F Martino, Margaret Ahmad
Cryptochromes are evolutionarily conserved blue-light absorbing flavoproteins which participate in many important cellular processes including in entrainment of the circadian clock in plants, Drosophila and humans. Drosophila melanogaster cryptochrome (DmCry) absorbs light through a flavin (FAD) cofactor that undergoes photoreduction to the anionic radical (FAD•-) redox state both in vitro and in vivo. However, recent efforts to link this photoconversion to the initiation of a biological response have remained controversial...
2017: PloS One
https://www.readbyqxmd.com/read/28296130/determinants-of-quality-of-life-outcomes-for-survivors-of-pediatric-brain-tumors
#8
Maru Barrera, Eshetu G Atenafu, Fiona Schulte, Ute Bartels, Lillian Sung, Laura Janzen, Joanna Chung, Danielle Cataudella, Kelly Hancock, Amani Saleh, Douglas Strother, Dina McConnell, Andrea Downie, Juliette Hukin, Shayna Zelcer
INTRODUCTION: To describe the quality of life (QOL) of pediatric brain tumor survivors (PBTSs) prospectively and to identify potential medical, personal and family contextual factors associated with QOL. METHODS: Ninety-one PBTSs (8-16 years) who were off treatment and attending a regular classroom participated. Self- and caregiver-proxy-reported on QOL at baseline, 2 and 8 months. At baseline, cognitive, executive function, attention and memory, medical and demographics information were attained...
March 10, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28293223/bacterial-community-and-phb-accumulating-bacteria-associated-with-the-wall-and-specialized-niches-of-the-hindgut-of-the-forest-cockchafer-melolontha-hippocastani
#9
Pol Alonso-Pernas, Erika Arias-Cordero, Alexey Novoselov, Christina Ebert, Jürgen Rybak, Martin Kaltenpoth, Martin Westermann, Ute Neugebauer, Wilhelm Boland
A characterization of the bacterial community of the hindgut wall of two larval and the adult stages of the forest cockchafer (Melolontha hippocastani) was carried out using amplicon sequencing of the 16S rRNA gene fragment. We found that, in second-instar larvae, Caulobacteraceae and Pseudomonadaceae showed the highest relative abundances, while in third-instar larvae, the dominant families were Porphyromonadaceae and Bacteroidales-related. In adults, an increase of the relative abundance of Bacteroidetes, Proteobacteria (γ- and δ- classes) and the family Enterococcaceae (Firmicutes) was observed...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28289534/dysphagia-after-arteria-lusoria-dextra-surgery-anatomical-considerations-before-redo-surgery
#10
Judith Mayer, Natascha van der Werf-Grohmann, Johannes Kroll, Ute Spiekerkoetter, Brigitte Stiller, Jochen Grohmann
Aberrant right subclavian artery (arteria lusoria) is the most common congenital root anomaly, remaining asymptomatic in most cases. Nevertheless, some of the 20%-40% of those affected present tracheo-esophageal symptoms. We report on a 6-year-old previously healthy girl presenting with progressive dysphagia over 4 wk. Diagnostics including barium swallow, echocardiography and magnetic resonance angiography (MRA) revealed a retro-esophageal compression by an aberrant right subclavian artery. Despite the successful, uneventful transposition of this arteria lusoria to the right common carotid via right-sided thoracotomy, the girl was suffering from persisting dysphagia...
February 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28287781/stability-and-change-in-subjective-well-being-the-role-of-performance-based-and-self-rated-cognition
#11
Tina Braun, Stefan C Schmukle, Ute Kunzmann
The primary goal of this study was to address the stability-despite-loss paradox of subjective well-being. Performance-based and self-evaluative measures of cognitive functioning were examined as predictors of subjective well-being in middle-aged and older adults using data from the Interdisciplinary Longitudinal Study of Adult Development (ILSE). Consistent with past work, subjective well-being remained relatively stable over a period of 12 years in both age groups, although performance-based and self-rated cognition declined over time...
March 2017: Psychology and Aging
https://www.readbyqxmd.com/read/28287735/targeted-antibiotic-delivery-selective-siderophore-conjugation-with-daptomycin-confers-potent-activity-against-multi-drug-resistant-acinetobacter-baumannii-both-in-vitro-and-in-vivo
#12
Manuka Ghosh, Patricia A Miller, Ute Möllmann, William D Claypool, Valerie A Schroeder, William R Wolter, Mark Suckow, Honglin Yu, Shuang Li, Weiqiang Huang, Jaroslav Zajicek, Marvin J Miller
In order to address the dire need for new antibiotics to treat specific strains of drug resistant Gram-negative bacterial infections, a mixed ligand analog of the natural Acinetobacter baumannii selective siderophore, fimsbactin, was coupled to daptomycin, a Gram-positive only antibiotic. The resulting conjugate, 11, has potent activity against multi-drug resistant strains of A. baumannii, both in vitro and in vivo. The study also indicates that conjugation of siderophores to "drugs" that are much larger than the siderophore (iron transport agent) itself facilitates active uptake that circumvents the normal permeability problems in Gram-negative bacteria...
March 13, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28287277/inhibitory-potential-of-strepthonium-a-against-shiga-toxin-production-in-enterohemorrhagic-escherichia-coli-ehec-strain-edl933
#13
Cheng Cheng, Srikkanth Balasubramanian, Agnes Fekete, Markus Krischke, Martin J Mueller, Ute Hentschel, Tobias A Oelschlaeger, Usama Ramadan Abdelmohsen
The production of shiga toxin (Stx) is a critical step in the establishment and progress of enterohemorrhagic Escherichia coli (EHEC) infections. The possible release of Stx from dead and dying bacteria, and the risk of resistance development have restricted the usage of antibiotics against EHEC. The chlorinated quaternary ammonium compound, strepthonium A, was isolated from the culture of Streptomyces sp. SBT345 that was cultivated from the Mediterranean sponge Agelas oroides. The structure was elucidated and confirmed by spectroscopic analyses including 1D and 2D NMR, ESI-HRMS, as well as ESI-HRMS(2)...
March 13, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28283853/long-t2-suppression-in-native-lung-3-d-imaging-using-k-space-reordered-inversion-recovery-dual-echo-ultrashort-echo-time-mri
#14
Neville D Gai, Ashkan A Malayeri, David A Bluemke
OBJECTIVE: Long T2 species can interfere with visualization of short T2 tissue imaging. For example, visualization of lung parenchyma can be hindered by breathing artifacts primarily from fat in the chest wall. The purpose of this work was to design and evaluate a scheme for long T2 species suppression in lung parenchyma imaging using 3-D inversion recovery double-echo ultrashort echo time imaging with a k-space reordering scheme for artifact suppression. MATERIALS AND METHODS: A hyperbolic secant (HS) pulse was evaluated for different tissues (T1/T2)...
March 10, 2017: Magma
https://www.readbyqxmd.com/read/28283847/increased-plasma-concentrations-of-soluble-st2-independently-predict-mortality-but-not-cardiovascular-events-in-stable-coronary-heart-disease-patients-13-year-follow-up-of-the-karola-study
#15
Vanessa Pfetsch, Veronika Sanin, Andrea Jaensch, Dhayana Dallmeier, Ute Mons, Hermann Brenner, Wolfgang Koenig, Dietrich Rothenbacher
PURPOSE: sST2 (soluble suppression of tumorigenicity 2), a member of the interleukin-1 family, has been suggested to play a role in cardiac remodeling and inflammatory signaling. We assessed the association between sST2 in patients with stable coronary heart disease (CHD) with multiple cardiovascular outcomes and total mortality, simultaneously controlling for a large number of potential confounders. METHODS: Plasma concentrations of sST2 (ELISA, Critical Diagnostics) were measured at baseline in a cohort of 1081 patients...
March 10, 2017: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/28283652/brca2-hypomorphic-missense-variants-confer-moderate-risks-of-breast-cancer
#16
Hermela Shimelis, Romy L S Mesman, Catharina Von Nicolai, Asa Ehlen, Lucia Guidugli, Charlotte Martin, Fabienne Mgr Calleja, Huong Meeks, Emily Hallberg, Jamie Hinton, Jenna Lilyquist, Chunling Hu, Cora M Aalfs, Kristiina Aittomaki, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Matthias W Beckmann, Javier J Benitez, Natalia Bogdanova, Stig E Bojesen, Manjeet K Bolla, Anne-Lise Borresen-Dale, Hiltrud Brauch, Paul Brennan, Hermann Brenner, Annegien Broeks, Barbara Brouwers, Thomas Bruning, Barbara Burwinkel, Jenny Chang-Claude, Georgia Chenevix-Trench, Ching-Yu Cheng, Ji-Yeob Choi, J Margriet Collée, Angela Cox, Simon S Cross, Kamila Czene, Hatef Darabi, Joe Dennis, Thilo Dork, Isabel Dos Santos Silva, Alison M Dunning, Peter A Fasching, Jonine D Figueroa, Henrik Flyger, Montserrat Garcia-Closas, Graham G Giles, Gord Glendon, Pascal Guenel, Christopher A Haiman, Per Hall, Ute Hamann, Mikael Hartman, Frans B L Hogervorst, Antoinette Hollestelle, John L Hopper, Hidemi Ito, Anna Jakubowska, Daehee Kang, Veli-Matti Kosma, Vessela Kristensen, Kah-Nyin Lai, Diether Lambrechts, Loic Le Marchand, Jingmei Li, Annika Lindblom, Artitaya Lophatananon, Jan Lubinski, Eva Machackova, Arto Mannermaa, Sara Margolin, Frederik Marme, Keitaro Matsuo, Hui Miao, Kyriaki Michailidou, Roger L Milne, Kenneth Muir, Susan L Neuhausen, Heli Nevanlinna, Janet E Olson, Curtis Olswold, Jan C Oosterwijk, Ana Osorio, Paolo Peterlongo, Julian Peto, Paul D P Pharoah, Katri Pylkäs, Paolo Radice, Muhammad U Rashid, Valerie Rhenius, Anja Rudolph, Suleeporn Sangrajrang, Elinor J Sawyer, Marjanka K Schmidt, Minouk J Schoemaker, Caroline M Seynaeve, Mitul Shah, Chen-Yang Shen, Martha J Shrubsole, Xiao-Ou Shu, Susan L Slager, Melissa C Southey, Daniel O Stram, Anthony J Swerdlow, Soo Hwang Teo, Ian Tomlinson, Diana Torres, Therese Truong, Christi J van Asperen, Lizet E van der Kolk, Qin Wang, Robert Winqvist, Anna H Wu, Jyh-Cherng Yu, Wei Zheng, Ying Zheng, Jennifer Leary, Logan C Walker, Lenka Foretova, Florentia Fostira, Kathleen Claes, Liliana Varesco, Setareh Moghadasi, Douglas F Easton, Amanda B Spurdle, Peter Devilee, Harry Vrieling, Alvaro N Monteiro, David E Goldgar, Aura Carreira, Maaike P G Vreeswijk, Fergus J Couch
Breast cancer risks conferred by many germline missense variants in the BRCA1 and BRCA2 genes, often referred to as variants of uncertain significance (VUS), have not been established. In this study, associations between 19 BRCA1 and 33 BRCA2 missense substitution variants and breast cancer risk were investigated through a breast cancer case control study using genotyping data from 38 studies of predominantly European ancestry (41,890 cases and 41,607 controls) and nine studies of Asian ancestry (6,269 cases and 6,624 controls)...
March 10, 2017: Cancer Research
https://www.readbyqxmd.com/read/28282092/nir-emitting-and-photo-thermal-active-nanogold-as-mitochondria-specific-probes
#17
Sabyasachi Chakrabortty, Miguel Sison, Yuzhou Wu, Anita Ladenburger, Goutam Pramanik, Johannes Biskupek, Jerome Extermann, Ute Kaiser, Theo Lasser, Tanja Weil
We report a bioinspired multifunctional albumin derived polypeptide coating comprising grafted poly(ethylene oxide) chains, multiple copies of the HIV TAT derived peptide enabling cellular uptake as well as mitochondria targeting triphenyl-phosphonium (TPP) groups. Exploring these polypeptide copolymers for passivating gold nanoparticles (Au NPs) yielded (i) NIR-emitting markers in confocal microscopy and (ii) photo-thermal active probes in optical coherence microscopy. We demonstrate the great potential of such multifunctional protein-derived biopolymer coatings for efficiently directing Au NP into cells and to subcellular targets to ultimately probe important cellular processes such as mitochondria dynamics and vitality inside living cells...
March 10, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28280570/a-method-for-detecting-characteristic-patterns-in-social-interactions-with-an-application-to-handover-interactions
#18
Nikolai W F Bode, Andrew Sutton, Lindsey Lacey, John G Fennell, Ute Leonards
Social interactions are a defining behavioural trait of social animals. Discovering characteristic patterns in the display of such behaviour is one of the fundamental endeavours in behavioural biology and psychology, as this promises to facilitate the general understanding, classification, prediction and even automation of social interactions. We present a novel approach to study characteristic patterns, including both sequential and synchronous actions in social interactions. The key concept in our analysis is to represent social interactions as sequences of behavioural states and to focus on changes in behavioural states shown by individuals rather than on the duration for which they are displayed...
January 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28277540/p53-loss-of-heterozygosity-is-a-necessary-prerequisite-for-mutant-p53-stabilization-and-gain-of-function-in-vivo
#19
Evguenia M Alexandrova, Safia A Mirza, Sulan Xu, Ramona Schulz-Heddergott, Natalia D Marchenko, Ute M Moll
Missense mutations in TP53 comprise >75% of all p53 alterations in cancer, resulting in highly stabilized mutant p53 proteins that not only lose their tumor-suppressor activity, but often acquire oncogenic gain-of-functions (GOFs). GOF manifests itself in accelerated tumor onset, increased metastasis, increased drug resistance and shortened survival in patients and mice. A known prerequisite for GOF is mutant p53 protein stabilization, which itself is linked to aberrant protein conformation. However, additional determinants for mutant p53 stabilization likely exist...
March 9, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28276471/meprin-metalloproteases-generate-biologically-active-soluble-interleukin-6-receptor-to-induce-trans-signaling
#20
Philipp Arnold, Inga Boll, Michelle Rothaug, Neele Schumacher, Frederike Schmidt, Rielana Wichert, Janna Schneppenheim, Juliane Lokau, Ute Pickhinke, Tomas Koudelka, Andreas Tholey, Björn Rabe, Jürgen Scheller, Ralph Lucius, Christoph Garbers, Stefan Rose-John, Christoph Becker-Pauly
Soluble Interleukin-6 receptor (sIL-6R) mediated trans-signaling is an important pro-inflammatory stimulus associated with pathological conditions, such as arthritis, neurodegeneration and inflammatory bowel disease. The sIL-6R is generated proteolytically from its membrane bound form and A Disintegrin And Metalloprotease (ADAM) 10 and 17 were shown to perform ectodomain shedding of the receptor in vitro and in vivo. However, under certain conditions not all sIL-6R could be assigned to ADAM10/17 activity. Here, we demonstrate that the IL-6R is a shedding substrate of soluble meprin α and membrane bound meprin β, resulting in bioactive sIL-6R that is capable of inducing IL-6 trans-signaling...
March 9, 2017: Scientific Reports
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