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https://www.readbyqxmd.com/read/28109179/quantitative-and-integrative-analysis-of-paracrine-hepatocyte-activation-by-non-parenchymal-cells-upon-lipopolysaccharide-induction
#1
Katharina Beuke, Frank A Schildberg, Federico Pinna, Ute Albrecht, Roman Liebe, Michaela Bissinger, Peter Schirmacher, Steven Dooley, Johannes G Bode, Percy A Knolle, Ursula Kummer, Kai Breuhahn, Sven Sahle
Gut-derived bacterial lipopolysaccharides (LPS) stimulate the secretion of tumor necrosis factor (TNF) from liver macrophages (MCs), liver sinusoidal endothelial cells (LSECs), and hepatic stellate cells (HSCs), which control the acute phase response in hepatocytes through activation of the NF-κB pathway. The individual and cooperative impact of non-parenchymal cells on this clinically relevant response has not been analysed in detail due to technical limitations. To gain an integrative view on this complex inter- and intracellular communication, we combined a multi-scale mathematical model with quantitative, time-resolved experimental data of different primary murine liver cell types...
January 21, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28107587/p450-bm3-catalyzed-regio-and-stereoselective-hydroxylation-aiming-at-the-synthesis-of-phthalides-and-isocoumarins
#2
Claudia Holec, Ute Hartrampf, Katharina Neufeld, Joerg Pietruszka
Cytochrome P450 BM3 monooxygenases are able to catalyze the regio- and stereoselective oxygenation of a broad range of substrates with promising potential for synthetic applications. To study the ability of P450 BM3 variants for the stereoselective benzylic hydroxylation of 2-alkylated benzoic acid esters, the biotransformation of methyl 2-ethylbenzoate was investigated resulting in both enantiomeric forms of 3-methylphthalide. In case of methyl 2-propylbenzoate as a substrate the regioselectivity of the reaction was shifted towards -hydroxylation resulting in the synthesis of enantioenriched (R)- and (S)-configured 3-methylisochroman-1-one...
January 20, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28106668/primidone-inhibits-trpm3-and-attenuates-thermal-nociception-in-vivo
#3
Ute Krügel, Isabelle Straub, Holger Beckmann, Michael Schaefer
The melastatin-related transient receptor potential channel TRPM3 is a nonselective cation channel expressed in nociceptive neurons and activated by heat. Since TRPM3-deficient mice show inflammatory thermal hyperalgesia, pharmacological inhibition of TRPM3 may exert antinociceptive properties. Fluorometric Ca influx assays and a compound library containing approved or clinically tested drugs were used to identify TRPM3 inhibitors. Biophysical properties of channel inhibition were assessed using electrophysiological methods...
January 12, 2017: Pain
https://www.readbyqxmd.com/read/28104500/photographic-assessment-of-retinal-hemorrhages-in-infant-head-injury-the-childhood-hemorrhagic-retinopathy-study
#4
Gaurav Bhardwaj, Mark B Jacobs, Frank J Martin, Kieran T Moran, Kristina Prelog, Craig Donaldson, Ute Vollmer-Conna, Minas T Coroneo
BACKGROUND: Retinal hemorrhages (RH) in babies in the absence of severe trauma or a medical cause have been strongly associated with abusive head trauma (AHT). We examined the pattern of RH in accidental head injury and AHT objectively using widefield retinal imaging. METHODS: A total of 118 infants and children 1-36 months of age admitted with head injuries at two centers were included in this prospective, consecutive, comparative cohort study. Dilated fundus examination was performed with indirect ophthalmoscopy and widefield imaging...
January 16, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28102423/synthesis-and-solution-stability-of-water-soluble-%C3%AE%C2%BA-2-n-%C3%AE%C2%BAo-bis-3-5-dimethylpyrazolyl-ethanol-manganese-i-tricarbonyl-bromide-corm-onn1
#5
Ralf Mede, Juliane Traber, Moritz Klein, Helmar Görls, Guido Gessner, Patrick Hoffmann, Michael Schmitt, Jürgen Popp, Stefan H Heinemann, Ute Neugebauer, Matthias Westerhausen
The reaction of (OC)5MnBr with bis(3,5-dimethyl-1-pyrazolyl)methane yields [{(Pz(Me2))2CH2}Mn(CO)3Br] (1). The use of tridentate heteroscorpionates such as bis(3,5-dimethyl-1-pyrazolyl)acetic acid and 2,2-bis(3,5-dimethyl-1-pyrazolyl)ethanol leads to the formation of mononuclear [(OC)3Mn{(Pz(Me2))2CH-CO2}] (2) and [(OC)3Mn{(Pz(Me2))2CH-CH2OH}]Br (3, CORM-ONN1). Salt-like photoCORM 3 is soluble in aqueous media up to a concentration of 200 μM, non-toxic up to an approx. 65 μM solution and releases all carbonyl ligands upon irradiation...
January 19, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28097818/staging-evaluation-and-response-criteria-harmonization-search-for-childhood-adolescent-and-young-adult-hodgkin-lymphoma-cayahl-methodology-statement
#6
Jamie E Flerlage, Kara M Kelly, Auke Beishuizen, Steve Cho, Pedro A De Alarcon, Ute Dieckmann, Richard A Drachtman, Bradford S Hoppe, Scott C Howard, Sue C Kaste, Regine Kluge, Lars Kurch, Judith Landman-Parker, Jocelyn Lewis, Michael P Link, Kathleen McCarten, Angela Punnett, Dietrich Stoevesandt, Stephan D Voss, William Hamish Wallace, Christine Mauz-Körholz, Monika L Metzger
International harmonization of staging evaluation and response criteria is needed for childhood, adolescence, and young adulthood Hodgkin lymphoma. Two Hodgkin lymphoma protocols from cooperative trials in Europe and North America were compared for areas in need of harmonization, and an evidence-based approach is currently underway to harmonize staging and response evaluations with a goal to enhance comparisons, expedite identification of effective therapies, and aid in the approval process for new agents by regulatory agencies...
January 18, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28097740/in%C3%A2-vivo-dearomatization-of-the-potent-antituberculosis-agent-btz043-via-meisenheimer-complex-formation
#7
Florian Kloss, Viktor Krchnak, Anna Krchnakova, Sebastian Schieferdecker, Julia Dreisbach, Volker Krone, Ute Möllmann, Michael Hoelscher, Marvin J Miller
Nitrobenzothiazinones are among the most potent antituberculosis agents. Herein, we disclose an unprecedented in vivo reduction process that affords Meisenheimer complexes of the clinical candidates BTZ043 and PBTZ169. The reduction is reversible, occurs in all mammalian species investigated, has a profound influence on the in vivo ADME characteristics, and has considerable implications for the design and implementation of clinical studies. The reduction was confirmed by chemical studies that enabled the complete characterization of the Meisenheimer complex and its subsequent chemistry...
January 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28097433/early-integration-of-palliative-supportive-cancer-care-healthcare-professionals-perspectives-on-the-support-needs-of-cancer-patients-and-their-caregivers-across-the-cancer-treatment-trajectory
#8
Amy Rohrmoser, Martina Preisler, Konrad Bär, Anne Letsch, Ute Goerling
PURPOSE: Delivering palliative/supportive cancer care (PSCC) early in the course of cancer care can enhance patients' and caregivers' quality of life, reduce anxiety and depression, and prolong patients' lives. However, their support needs are analyzed insufficiently from viewpoints other than their own. The goal of this study was to explore the perspectives of healthcare professionals on desirable standards of support for tumor patients and caregivers across the cancer treatment trajectory...
January 17, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28097321/diagnostic-yield-and-novel-candidate-genes-by-exome-sequencing-in-152-consanguineous-families-with-neurodevelopmental-disorders
#9
Miriam S Reuter, Hasan Tawamie, Rebecca Buchert, Ola Hosny Gebril, Tawfiq Froukh, Christian Thiel, Steffen Uebe, Arif B Ekici, Mandy Krumbiegel, Christiane Zweier, Juliane Hoyer, Karolin Eberlein, Judith Bauer, Ute Scheller, Tim M Strom, Sabine Hoffjan, Ehab R Abdelraouf, Nagwa A Meguid, Ahmad Abboud, Mohammed Ayman Al Khateeb, Mahmoud Fakher, Saber Hamdan, Amina Ismael, Safia Muhammad, Ebtessam Abdallah, Heinrich Sticht, Dagmar Wieczorek, André Reis, Rami Abou Jamra
Importance: Autosomal recessive inherited neurodevelopmental disorders are highly heterogeneous, and many, possibly most, of the disease genes are still unknown. Objectives: To promote the identification of disease genes through confirmation of previously described genes and presentation of novel candidates and provide an overview of the diagnostic yield of exome sequencing in consanguineous families. Design, Setting, and Participants: Autozygosity mapping in families and exome sequencing of index patients were performed in 152 consanguineous families (the parents descended from a same ancestor) with at least 1 offspring with intellectual disability (ID)...
January 11, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28093680/the-international-diffuse-intrinsic-pontine-glioma-registry-an-infrastructure-to-accelerate-collaborative-research-for-an-orphan-disease
#10
Joshua Baugh, Ute Bartels, James Leach, Blaise Jones, Brooklyn Chaney, Katherine E Warren, Jenavieve Kirkendall, Renee Doughman, Cynthia Hawkins, Lili Miles, Christine Fuller, Tim Hassall, Eric Bouffet, Adam Lane, Darren Hargrave, Jacques Grill, Lindsey M Hoffman, Chris Jones, Alex Towbin, Sharon A Savage, Michelle Monje, Xiao-Nan Li, David S Ziegler, Sophie Veldhuijzen van Zanten, Christof M Kramm, Dannis G van Vuurden, Maryam Fouladi
Diffuse intrinsic pontine glioma (DIPG), a rare, often fatal childhood brain tumor, remains a major therapeutic challenge. In 2012, investigators, funded by the DIPG Collaborative (a philanthropic partnership among 29 private foundations), launched the International DIPG Registry (IDIPGR) to advance understanding of DIPG. Comprised of comprehensive deidentified but linked clinical, imaging, histopathological, and genomic repositories, the IDIPGR uses standardized case report forms for uniform data collection; serial imaging and histopathology are centrally reviewed by IDIPGR neuro-radiologists and neuro-pathologists, respectively...
January 16, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28090666/quantitative-ultrashort-echo-time-imaging-for-assessment-of-massive-iron-overload-at-1-5-and-3-tesla
#11
Axel J Krafft, Ralf B Loeffler, Ruitian Song, Aaryani Tipirneni-Sajja, M Beth McCarville, Matthew D Robson, Jane S Hankins, Claudia M Hillenbrand
PURPOSE: Hepatic iron content (HIC) quantification via transverse relaxation rate (R2*)-MRI using multi-gradient echo (mGRE) imaging is compromised toward high HIC or at higher fields due to the rapid signal decay. Our study aims at presenting an optimized 2D ultrashort echo time (UTE) sequence for R2* quantification to overcome these limitations. METHODS: Two-dimensional UTE imaging was realized via half-pulse excitation and radial center-out sampling. The sequence includes chemically selective saturation pulses to reduce streaking artifacts from subcutaneous fat, and spatial saturation (sSAT) bands to suppress out-of-slice signals...
January 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28090655/30-second-bound-and-pore-water-concentration-mapping-of-cortical-bone-using-2d-ute-with-optimized-half-pulses
#12
Mary Kate Manhard, Kevin D Harkins, Daniel F Gochberg, Jeffry S Nyman, Mark D Does
PURPOSE: MRI of cortical bone has the potential to offer new information about fracture risk. Current methods are typically performed with 3D acquisitions, which suffer from long scan times and are generally limited to extremities. This work proposes using 2D UTE with half pulses for quantitatively mapping bound and pore water in cortical bone. METHODS: Half-pulse 2D UTE methods were implemented on a 3T Philips Achieva scanner using an optimized slice-select gradient waveform, with preparation pulses to selectively image bound or pore water...
January 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28090450/quantitative-magnetic-resonance-imaging-of-the-lumbar-intervertebral-discs
#13
REVIEW
Dosik Hwang, Sewon Kim, Nirusha A Abeydeera, Sheronda Statum, Koichi Masuda, Christine B Chung, Palanan Siriwanarangsun, Won C Bae
Human lumbar spine is composed of multiple tissue components that serve to provide structural stability and proper nutrition. Conventional magnetic resonance (MR) imaging techniques have been useful for evaluation of IVD, but inadequate at imaging the discovertebral junction and ligamentous tissues due primarily to their short T2 nature. Ultrashort time to echo (UTE) MR techniques acquire sufficient MR signal from these short T2 tissues, thereby allowing direct and quantitative evaluation. This article discusses the anatomy of the lumbar spine, MR techniques available for morphologic and quantitative MR evaluation of long and short T2 tissues of the lumbar spine, considerations for T2 relaxation modeling and fitting, and existing and new techniques for spine image post-processing, focusing on segmentation...
December 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28090449/ultrashort-time-to-echo-magnetic-resonance-techniques-for-the-musculoskeletal-system
#14
REVIEW
Palanan Siriwanarangsun, Sheronda Statum, Reni Biswas, Won C Bae, Christine B Chung
Magnetic resonance (MR) imaging has been widely implemented as a non-invasive modality to investigate musculoskeletal (MSK) tissue disease, injury, and pathology. Advancements in MR sequences provide not only enhanced morphologic contrast for soft tissues, but also quantitative biochemical evaluation. Ultrashort time to echo (UTE) sequence, in particular, enables novel morphologic and quantitative evaluation of previously unseen MSK tissues. By using short minimum echo times (TE) below 1 msec, the UTE sequence can unveil short T2 properties of tissues including the deepest layers of the articular cartilage, cartilaginous endplate at the discovertebral junction, the meniscus, and the cortical bone...
December 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28090199/mastr-ms-a-web-based-collaborative-laboratory-information-management-system-lims-for-metabolomics
#15
Adam Hunter, Saravanan Dayalan, David De Souza, Brad Power, Rodney Lorrimar, Tamas Szabo, Thu Nguyen, Sean O'Callaghan, Jeremy Hack, James Pyke, Amsha Nahid, Roberto Barrero, Ute Roessner, Vladimir Likic, Dedreia Tull, Antony Bacic, Malcolm McConville, Matthew Bellgard
BACKGROUND: An increasing number of research laboratories and core analytical facilities around the world are developing high throughput metabolomic analytical and data processing pipelines that are capable of handling hundreds to thousands of individual samples per year, often over multiple projects, collaborations and sample types. At present, there are no Laboratory Information Management Systems (LIMS) that are specifically tailored for metabolomics laboratories that are capable of tracking samples and associated metadata from the beginning to the end of an experiment, including data processing and archiving, and which are also suitable for use in large institutional core facilities or multi-laboratory consortia as well as single laboratory environments...
2017: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/28089870/large-dense-core-vesicle-exocytosis-from-mouse-dorsal-root-ganglion-neurons-is-regulated-by-neuropeptide-y
#16
Anneka Bost, Ali H Shaib, Yvonne Schwarz, Barbara A Niemeyer, Ute Becherer
Peptidergic dorsal root ganglion (DRG) neurons transmit sensory and nociceptive information from the periphery to the central nervous system. Their synaptic activity is profoundly affected by neuromodulatory peptides stored and released from large dense-core vesicles (LDCVs). However, the mechanism of peptide secretion from DRG neurons is poorly understood. Using total internal reflection fluorescence microscopy (TIRFM), we visualized individual LDCVs loaded with fluorescent neuropeptide Y (NPY) and analyzed their stimulation-dependent release...
January 12, 2017: Neuroscience
https://www.readbyqxmd.com/read/28088288/a-novel-mouse-model-of-staphylococcus-aureus-vascular-graft-infection-noninvasive-imaging-of-biofilm-development-in%C3%A2-vivo
#17
Hélène Van de Vyver, Philipp R Bovenkamp, Verena Hoerr, Katrin Schwegmann, Lorena Tuchscherr, Silke Niemann, Laura Kursawe, Christina Grosse, Annette Moter, Uwe Hansen, Ute Neugebauer, Michael T Kuhlmann, Georg Peters, Sven Hermann, Bettina Löffler
Staphylococcus aureus causes very serious infections of vascular grafts. Knowledge of the molecular mechanisms of this disease is largely lacking because of the absence of representable models. Therefore, the aim of this study was to set up a mouse model of vascular graft infections that closely mimics the human situation. A catheter was inserted into the right carotid artery of mice, which acted as a vascular graft. Mice were infected i.v. using 8 different S. aureus strains, and development of the infection was followed up...
January 4, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28087238/lymphocyte-circadian-clocks-control-lymph-node-trafficking-and-adaptive-immune-responses
#18
David Druzd, Olga Matveeva, Louise Ince, Ute Harrison, Wenyan He, Christoph Schmal, Hanspeter Herzel, Anthony H Tsang, Naoto Kawakami, Alexei Leliavski, Olaf Uhl, Ling Yao, Leif Erik Sander, Chien-Sin Chen, Kerstin Kraus, Alba de Juan, Sophia Martina Hergenhan, Marc Ehlers, Berthold Koletzko, Rainer Haas, Werner Solbach, Henrik Oster, Christoph Scheiermann
Lymphocytes circulate through lymph nodes (LN) in search for antigen in what is believed to be a continuous process. Here, we show that lymphocyte migration through lymph nodes and lymph occurred in a non-continuous, circadian manner. Lymphocyte homing to lymph nodes peaked at night onset, with cells leaving the tissue during the day. This resulted in strong oscillations in lymphocyte cellularity in lymph nodes and efferent lymphatic fluid. Using lineage-specific genetic ablation of circadian clock function, we demonstrated this to be dependent on rhythmic expression of promigratory factors on lymphocytes...
January 17, 2017: Immunity
https://www.readbyqxmd.com/read/28076365/gene-expression-profiling-in-slow-type-calf-soleus-muscle-of-30-days-space-flown-mice
#19
Guido Gambara, Michele Salanova, Stefano Ciciliot, Sandra Furlan, Martina Gutsmann, Gudrun Schiffl, Ute Ungethuem, Pompeo Volpe, Hanns-Christian Gunga, Dieter Blottner
Microgravity exposure as well as chronic disuse are two main causes of skeletal muscle atrophy in animals and humans. The antigravity calf soleus is a reference postural muscle to investigate the mechanism of disuse-induced maladaptation and plasticity of human and rodent (rats or mice) skeletal musculature. Here, we report microgravity-induced global gene expression changes in space-flown mouse skeletal muscle and the identification of yet unknown disuse susceptible transcripts found in soleus (a mainly slow phenotype) but not in extensor digitorum longus (a mainly fast phenotype dorsiflexor as functional counterpart to soleus)...
2017: PloS One
https://www.readbyqxmd.com/read/28075593/formation-of-nickel-clusters-wrapped-in-carbon-cages-toward-new-endohedral-metallofullerene-synthesis
#20
Alexander S Sinitsa, Thomas W Chamberlain, Thilo Zoberbier, Irina V Lebedeva, Andrey M Popov, Andrey A Knizhnik, Robert L McSweeney, Johannes Biskupek, Ute Kaiser, Andrei N Khlobystov
Despite the high potential of endohedral metallofullerenes (EMFs) for application in biology, medicine and molecular electronics, and recent efforts in EMF synthesis, the variety of EMFs accessible by conventional synthetic methods remains limited and does not include, for example, EMFs of late transition metals. We propose a method in which EMF formation is initiated by electron irradiation in aberration-corrected high-resolution transmission electron spectroscopy (AC-HRTEM) of a metal cluster surrounded by amorphous carbon inside a carbon nanotube serving as a nanoreactor and apply this method for synthesis of nickel EMFs...
January 18, 2017: Nano Letters
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