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https://www.readbyqxmd.com/read/29134529/transcriptional-changes-measured-in-rice-roots-after-exposure-to-arsenite-contaminated-sediments
#1
Alexandra Brinke, Georg Reifferscheid, Roland Klein, Ute Feiler, Sebastian Buchinger
Transcriptional analyses are discussed to provide a deeper understanding of the molecular mechanisms underlying toxic effects. Thus, they can complement classic ecotoxicological test methods and potentially allow the identification of biomarkers associated to the exposure of chemical stressors and or adverse biological effects. This feasibility study intended to identify a set of potential gene expression biomarkers for arsenite-exposure in rice roots that could complement the informative value of an existing sediment-contact test with rice...
November 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29132167/smoldering-development-of-acute-megakaryoblastic-leukemia-with-clonal-evolution-in-an-infant-without-down-syndrome
#2
Eva Schmidt, Ute Fischer, Wolfgang Biskup, Claudia Haferlach, Roland Meisel, Michaela Kuhlen, Arndt Borkhardt
No abstract text is available yet for this article.
November 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/29131856/examination-of-sarcocystis-spp-of-giant-snakes-from-australia-and-southeast-asia-confirms-presence-of-a-known-pathogen-sarcocystis-nesbitti
#3
Marion Wassermann, Lisa Raisch, Jessica Ann Lyons, Daniel James Deans Natusch, Sarah Richter, Mareike Wirth, Piyarat Preeprem, Yuvaluk Khoprasert, Sulaiman Ginting, Ute Mackenstedt, Thomas Jäkel
We examined Sarcocystis spp. in giant snakes from the Indo-Australian Archipelago and Australia using a combination of morphological (size of sporocyst) and molecular analyses. We amplified by PCR nuclear 18S rDNA from single sporocysts in order to detect mixed infections and unequivocally assign the retrieved sequences to the corresponding parasite stage. Sarcocystis infection was generally high across the study area, with 78 (68%) of 115 examined pythons being infected by one or more Sarcocystis spp. Among 18 randomly chosen, sporocyst-positive samples (11 from Southeast Asia, 7 from Northern Australia) the only Sarcocystis species detected in Southeast Asian snakes was S...
2017: PloS One
https://www.readbyqxmd.com/read/29127258/homozygous-mutation-in-cep19-a-gene-mutated-in-morbid-obesity-in-bardet-biedl-syndrome-with-predominant-postaxial-polydactyly
#4
Esra Yıldız Bölükbaşı, Sara Mumtaz, Muhammad Afzal, Ute Woehlbier, Sajid Malik, Aslıhan Tolun
BACKGROUND: Bardet-Biedl syndrome (BBS) is a ciliopathy with extensive phenotypic variability and genetic heterogeneity. We aimed to discover the gene mutated in a consanguineous kindred with multiple cases of a BBS phenotype. METHODS: SNP genotype data were used for linkage analysis and exome sequencing to identify mutations. Modelling and in silico analysis were performed to predict mutation severity. RESULTS: Patients had postaxial polydactyly plus variable other clinical features including rod-cone dystrophy, obesity, intellectual disability, renal malformation, developmental delay, dental anomalies, speech disorder and enlarged fatty liver...
November 10, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29126446/detection-level-and-pattern-of-positive-lesions-using-psma-pet-ct-for-staging-prior-to-radiation-therapy
#5
Nina-Sophie Schmidt-Hegemann, Wolfgang Peter Fendler, Alexander Buchner, Christian Stief, Paul Rogowski, Maximilian Niyazi, Chukwuka Eze, Minglun Li, Peter Bartenstein, Claus Belka, Ute Ganswindt
BACKGROUND: To determine the potential role of (68)Ga-PSMA positron emission tomography/computed tomography (PET/CT) in radiotherapy (RT) planning for prostate cancer (PCa). METHODS: One hundred twenty-nine patients (pts) with (68)Ga-PSMA PET/CT were retrospectively analysed. Potentially influencing factors (androgen deprivation therapy, amount of (68)Ga-PSMA-HBED-CC, PSA doubling time ≤/> 10 months, PSA before PET/CT, T-/N-category and Gleason score) were evaluated by logistic regression analysis...
November 10, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29121956/regional-differences-in-prognostic-value-of-cardiac-valve-plane-displacement-in-systemic-light-chain-amyloidosis
#6
Marco M Ochs, Thomas Fritz, Nisha Arenja, Johannes Riffel, Florian Andre, Derliz Mereles, Fabian Aus dem Siepen, Ute Hegenbart, Stefan Schönland, Hugo A Katus, Matthias G W Friedrich, Sebastian J Buss
BACKGROUND: To compare the prognostic value of cardiac valve plane displacement (CVPD) on various locations in cardiac light chain (AL) amyloidosis. METHODS: Consecutive patients with biopsy-proven cardiac involvement in AL amyloidosis who had undergone cardiovascular magnetic resonance (CMR) between 2005 and 2014 in our institution, were retrospectively identified and data analyzed. The primary combined endpoint was all-cause mortality or heart transplantation...
November 9, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29121689/-public-health-practice-results-of-the-working-group-12-of-the-forum-future-public-health-berlin-2016
#7
Ute Teichert, Stefan Bräunling, Karin Müller, Gesine Bär
This report focuses on the topic of Public Health in practice. The article summarizes the discussion of the Working Group 12. A first diagram shows how broad the definition of "Public Health practice" can be. Challenges as well as visions were articulated. In order to ensure individual and diverse health promotion for all, public health must be integrated as a central vision for the future in the daily routine and in the various living environments of the people as part of social life. To achieve this goal, public health actors in general and the public health service in particular must work closely with policy makers, cost-bearers, science and teaching and complement each other's work, while respecting their spheres of action...
November 9, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29118782/influence-of-mild-cognitive-impairment-depression-and-anxiety-on-the-quality-of-life-of-patients-with-parkinson-disease
#8
Daniel Wiesli, Antonia Meyer, Peter Fuhr, Ute Gschwandtner
Background: Neuropsychiatric symptoms (NPS) and mild cognitive impairment (MCI) are common in Parkinson disease (PD) and have a negative impact on the patient's quality of life (QoL). We aim to describe the effect of NPS and MCI on each other and on QoL. Methods: Sixteen MCI and 37 non-MCI PD patients completed different self-assessment questionnaires including the Parkinson's Disease Questionnaire (PDQ-39), the Beck Depression Inventory (BD), the Beck Anxiety Inventory (BAI), and the Self-Report Manic Inventory (SRMI)...
September 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/29118434/supernatural-belief-is-not-modulated-by-intuitive-thinking-style-or-cognitive-inhibition
#9
Miguel Farias, Valerie van Mulukom, Guy Kahane, Ute Kreplin, Anna Joyce, Pedro Soares, Lluis Oviedo, Mathilde Hernu, Karolina Rokita, Julian Savulescu, Riikka Möttönen
According to the Intuitive Belief Hypothesis, supernatural belief relies heavily on intuitive thinking-and decreases when analytic thinking is engaged. After pointing out various limitations in prior attempts to support this Intuitive Belief Hypothesis, we test it across three new studies using a variety of paradigms, ranging from a pilgrimage field study to a neurostimulation experiment. In all three studies, we found no relationship between intuitive or analytical thinking and supernatural belief. We conclude that it is premature to explain belief in gods as 'intuitive', and that other factors, such as socio-cultural upbringing, are likely to play a greater role in the emergence and maintenance of supernatural belief than cognitive style...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29118359/visualization-and-quantification-of-injury-to-the-ciliated-epithelium-using-quantitative-flow-imaging-and-speckle-variance-optical-coherence-tomography
#10
Ute A Gamm, Brendan K Huang, Emily K Mis, Mustafa K Khokha, Michael A Choma
Mucociliary flow is an important defense mechanism in the lung to remove inhaled pathogens and pollutants. Disruption of ciliary flow can lead to respiratory infections. Multiple factors, from drugs to disease can cause an alteration in ciliary flow. However, less attention has been given to injury of the ciliated epithelium. In this study, we show how optical coherence tomography (OCT) can be used to investigate injury to the ciliated epithelium in a multi-contrast setting. We used particle tracking velocimetry (PTV-OCT) to investigate the cilia-driven flow field and 3D speckle variance imaging to investigate size and extent of injury caused to the skin of Xenopus embryos...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29117200/feasibility-of-including-patients-with-migration-background-in-a-structured-heart-failure-management-programme-a-prospective-case-control-study-exemplarily-on-turkish-migrants
#11
Roman Pfister, Peter Ihle, Birgit Mews, Elisabeth Kohnen, Marcus Wähner, Ute Karbach, Hasan Aslan, Hans-Wilhelm Höpp, Christian Alfons Schneider
AIMS: Structured management programmes deliver optimized care in heart failure patients and improve outcome. We examined the feasibility of including patients with migration background speaking little or no German in a heart failure management programme. METHODS AND RESULTS: After adaption of script material and staff to Turkish language we aimed to recruit 300 Turkish and 300 German (control group) patients within 18 months using the operational basis of a local heart failure management programme for screening, contact and inclusion...
2017: PloS One
https://www.readbyqxmd.com/read/29116668/shaping-luminescent-properties-of-yb-3-and-ho-3-co-doped-upconverting-core-shell-%C3%AE-nayf4-nanoparticles-by-dopant-distribution-and-spacing
#12
Aleksandra Pilch, Christian Würth, Martin Kaiser, Dominika Wawrzyńczyk, Michalina Kurnatowska, Sebastian Arabasz, Katarzyna Prorok, Marek Samoć, Wiesław Strek, Ute Resch-Genger, Artur Bednarkiewicz
At the core of luminescence color and lifetime tuning of rare earth doped upconverting nanoparticles (UCNPs), is the understanding of the impact of the particle architecture for commonly used sensitizer (S) and activator (A) ions. In this respect, a series of core@shell NaYF4 UCNPs doped with Yb(3+) and Ho(3+) ions are presented here, where the same dopant concentrations are distributed in different particle architectures following the scheme: YbHo core and YbHo@…, …@YbHo, Yb@Ho, Ho@Yb, YbHo@Yb, and Yb@YbHo core-shell NPs...
November 8, 2017: Small
https://www.readbyqxmd.com/read/29116204/tuberculosis-in-swiss-captive-asian-elephants-microevolution-of-mycobacterium-tuberculosis-characterized-by-multilocus-variable-number-tandem-repeat-analysis-and-whole-genome-sequencing
#13
Giovanni Ghielmetti, Mireia Coscolla, Maja Ruetten, Ute Friedel, Chloé Loiseau, Julia Feldmann, Hanspeter W Steinmetz, David Stucki, Sebastien Gagneux
Zoonotic tuberculosis is a risk for human health, especially when animals are in close contact with humans. Mycobacterium tuberculosis was cultured from several organs, including lung tissue and gastric mucosa, of three captive elephants euthanized in a Swiss zoo. The elephants presented weight loss, weakness and exercise intolerance. Molecular characterization of the M. tuberculosis isolates by spoligotyping revealed an identical profile, suggesting a single source of infection. Multilocus variable-number of tandem-repeat analysis (MLVA) elucidated two divergent populations of bacteria and mixed infection in one elephant, suggesting either different transmission chains or prolonged infection over time...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29114775/development-of-pointing-gestures-in-children-with-typical-and-delayed-language-acquisition
#14
Carina Lüke, Ute Ritterfeld, Angela Grimminger, Ulf Liszkowski, Katharina J Rohlfing
Purpose: This longitudinal study compared the development of hand and index-finger pointing in children with typical language development (TD) and children with language delay (LD). First, we examined whether the number and the form of pointing gestures during the second year of life are potential indicators of later LD. Second, we analyzed the influence of caregivers' gestural and verbal input on children's communicative development. Method: Thirty children with TD and 10 children with LD were observed together with their primary caregivers in a seminatural setting in 5 sessions between the ages of 12 and 21 months...
November 9, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29112438/-oligo-thiophene-functionalized-tetraazaperopyrenes-donor-acceptor-dyes-and-ambipolar-organic-semiconductors
#15
Lena Hahn, André Hermannsdorfer, Benjamin Günther, Tobias Wesp, Bastian Bühler, Ute Zschieschang, Hubert Wadepohl, Hagen Klauk, Lutz H Gade
Tetraazaperopyrenes (TAPPs) have been functionalized with thiophene and terthiophene units of different architecture resulting in a variety of organic donor-acceptor (D-A) compounds. The influence of the connection of the thiophenes to the TAPP core on their structural, photophysical and electrochemical properties has been studied in detail by a combination of X-ray crystallography, UV/Vis and fluorescence spectroscopy as well as cyclic voltammetry, which allowed the establishment of structure-property relationships...
November 7, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29109529/glomerulocapillary-mirna-response-to-hla-class-i-antibody-in-vitro-and-in-vivo
#16
Falko M Heinemann, Peter T Jindra, Clemens L Bockmeyer, Philip Zeuschner, Juliane Wittig, Heike Höflich, Marc Eßer, Mahmoud Abbas, Georg Dieplinger, Katharina Stolle, Udo Vester, Peter F Hoyer, Stephan Immenschuh, Andreas Heinold, Peter A Horn, Wentian Li, Ute Eisenberger, Jan U Becker
Changes in miRNA expression glomerular of capillaries during antibody-mediated rejection (ABMR) are poorly understood and could contribute to the deleterious inflammation and fibrosis of ABMR via suppression of target genes. A better understanding could lead to novel diagnostic tools and reveal novel therapeutic targets. We explored deregulated miRNAs in an glomeruloendothelial in vitro model of ABMR due to class I human leukocyte antigen (HLA) with and without complement activation. We studied a set of 16 promising candidate miRNAs in microdissected glomeruli a confirmation set of 20 human transplant biopsies (DSA+) compared to 10 matched controls without evidence for ABMR...
November 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29106754/right-heart-function-in-impaired-left-ventricular-diastolic-function-2d-speckle-tracking-echocardiography-based-and-doppler-tissue-imaging-based-analysis-of-right-atrial-and-ventricular-function
#17
Anna Brand, Marny Bathe, Sabine Oertelt-Prigione, Ute Seeland, Mirjam Rücke, Vera Regitz-Zagrosek, Karl Stangl, Fabian Knebel, Verena Stangl, Henryk Dreger
AIM: The aim of our study was to describe right atrial (RA) and right ventricular (RV) function, assessed by Doppler tissue imaging and 2D speckle tracking echocardiography (2DSTE), in women with signs of early impaired left ventricular diastolic function (DD). METHODS AND RESULTS: In a cross-sectional trial, standard parameters of diastolic and right heart function were investigated in 438 women of the Berlin Female Risk Evaluation (BEFRI) study. In a subset of women, average peak systolic RA strain (RAS), as well as the average peak systolic RV strain of the free wall (RVS free wall) and of all RV segments (average RV strain; RVS Avg), was analyzed using 2DSTE...
November 6, 2017: Echocardiography
https://www.readbyqxmd.com/read/29106498/introducing-occupational-health-management-in-the-german-armed-forces
#18
Ute Latza, Eva Hampel, Markus Wiencke, Michaela Prigge, Andreas Schlattmann, Sabine Sommer
process evaluation, qualitative methods, worksite, healthy settings, implementation.
July 3, 2017: Health Promotion International
https://www.readbyqxmd.com/read/29104819/significance-of-scapholunate-gap-width-as-measured-by-probe-from-midcarpal
#19
Steffen Löw, Holger Erne, Ute Strobl, Frank Unglaub, Christian K Spies
Background  Geissler's classification is widely accepted in arthroscopic diagnostics of scapholunate (SL) ligament injury. Thereby, probe insertion into the SL gap from the midcarpal would indicate treatment necessity in patients with SL tear as seen from radiocarpal view. Purpose  In this review, the SL gap width, examined by the probe from midcarpal, was arthroscopically assessed in patients with intact SL ligaments, who were treated for ulnar impaction syndrome. The review examined how often lax SL joints can be found in patients with no complaints with respect to the SL ligaments and in which the SL ligaments were proven to be intact from radiocarpal view...
November 2017: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/29104561/among-early-appearing-non-motor-signs-of-parkinson-s-disease-alteration-of-olfaction-but-not-electroencephalographic-spectrum-correlates-with-motor-function
#20
Vitalii V Cozac, Bianca Auschra, Menorca Chaturvedi, Ute Gschwandtner, Florian Hatz, Antonia Meyer, Antje Welge-Lüssen, Peter Fuhr
Olfactory decline is a frequent and early non-motor symptom in Parkinson's disease (PD), which is increasingly used for diagnostic purposes. Another early appearing sign of PD consists in electroencephalographic (EEG) alterations. The combination of olfactory and EEG assessment may improve the identification of patients with early stages of PD. We hypothesized that olfactory capacity would be correlated with EEG alterations and motor and cognitive impairment in PD patients. To the best of our knowledge, the mutual influence of both markers of PD-olfactory decrease and EEG changes-was not studied before...
2017: Frontiers in Neurology
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