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https://www.readbyqxmd.com/read/28103644/flow-cytometric-osmotic-fragility-test-increased-assay-sensitivity-for-clinical-application-in-pediatric-hematology
#1
Olga Ciepiela, Anna Adamowicz-Salach, Agata Zgodzińska, Magdalena Łazowska, Iwona Kotuła
BACKGROUND: Osmotic Fragility Test (OFT) is widely considered as a sensitive indicator of red blood cells' sensitivity to the hypotonic solution. It is often used as a screening test for the diagnosis of hereditary spherocytosis (HS). Nowadays, the osmotic fragility test based on flow cytometric analysis (FCM OF) is widely used in laboratory practice. The purpose of this study was to optimize the assay sensitivity and to validate its clinical application in the diagnostic screening of childhood anemias...
January 19, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/28103632/global-health-and-emergency-care-defining-clinical-research-priorities
#2
Bhakti Hansoti, Adam R Aluisio, Meagan A Barry, Kevin Davey, Brian A Lentz, Payal Modi, Jennifer A Newberry, Melissa H Patel, Tricia A Smith, Alexandra M Vinograd, Adam C Levine
OBJECTIVES: Despite recent strides in the development of Global Emergency Medicine (EM), the field continues to lag in applying a scientific approach to identifying critical knowledge gaps and advancing evidence-based solutions to clinical and public health problems seen in emergency departments worldwide. Here, progress on the Global EM research agenda created at the 2013 Academic Emergency Medicine Global Health and Emergency Care Consensus Conference is evaluated and critical areas for future development in emergency care research internationally are identified...
January 19, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28103570/an-extreme-learning-machine-approach-to-density-estimation-problems
#3
Cristiano Cervellera, Danilo Maccio
In this paper, we discuss how the extreme learning machine (ELM) framework can be effectively employed in the unsupervised context of multivariate density estimation. In particular, two algorithms are introduced, one for the estimation of the cumulative distribution function underlying the observed data, and one for the estimation of the probability density function. The algorithms rely on the concept of $F$-discrepancy, which is closely related to the Kolmogorov-Smirnov criterion for goodness of fit. Both methods retain the key feature of the ELM of providing the solution through random assignment of the hidden feature map and a very light computational burden...
January 17, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28103566/exact-and-approximate-stability-of-solutions-to-traveling-salesman-problems
#4
Moritz Niendorf, Anouck R Girard
This paper presents the stability analysis of an optimal tour for the symmetric traveling salesman problem (TSP) by obtaining stability regions. The stability region of an optimal tour is the set of all cost changes for which that solution remains optimal and can be understood as the margin of optimality for a solution with respect to perturbations in the problem data. It is known that it is not possible to test in polynomial time whether an optimal tour remains optimal after the cost of an arbitrary set of edges changes...
January 17, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28103564/mograms-a-network-based-methodology-for-visualizing-the-set-of-nondominated-solutions-in-multiobjective-optimization
#5
Krzysztof Trawinski, Manuel Chica, David P Pancho, Sergio Damas, Oscar Cordon
An appropriate visualization of multiobjective nondominated solutions is a valuable asset for decision making. Although there are methods for visualizing the solutions in the design space, they do not provide any information about their relationship. In this paper, we propose a novel methodology that allows the visualization of the nondominated solutions in the design space and their relationships by means of a network. The nodes represent the solutions in the objective space while the edges show the relationships among the solutions in the design space...
January 16, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28103552/extending-the-utility-of-the-parabolic-approximation-in-medical-ultrasound-using-wide-angle-diffraction-modeling
#6
Joshua E Soneson
Wide-angle parabolic models are commonly used in geophysics and underwater acoustics but have seen little application in medical ultrasound. Here a wide-angle model for continuous-wave high-intensity ultrasound beams is derived which approximates the diffraction process more accurately than the commonly-used Khokhlov-Zabolotskaya-Kuznetsov (KZK) equation without increasing implementation complexity or computing time. A method for preventing the high spatial frequencies often present in source boundary conditions from corrupting the solution is presented...
January 16, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28103548/dimensionality-reduction-on-spd-manifolds-the-emergence-of-geometry-aware-methods
#7
Mehrtash Harandi, Mathieu Salzmann, Richard Hartley
Representing images and videos with Symmetric Positive Definite (SPD) matrices, and considering the Riemannian geometry of the resulting space, has been shown to yield high discriminative power in many visual recognition tasks. Unfortunately, computation on the Riemannian manifold of SPD matrices -especially of high-dimensional ones- comes at a high cost that limits the applicability of existing techniques. In this paper, we introduce algorithms able to handle high-dimensional SPD matrices by constructing a lower-dimensional SPD manifold...
January 18, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28103543/-digitally-inking-in-the-21st-century
#8
Michelle Annett
The ubiquity and mobility of contemporary computing devices has enabled users to consume content, anytime, anywhere. Yet, when we need to create content, touch input is far from perfect. When coupled with touch input, the stylus should enable users to simultaneously ink, manipulate the page, and switch between tools with ease, so why has the stylus yet to achieve universal adoption? Michelle Annett's thesis sought to understand the usability barriers and tensions that have prevented stylus input from gaining traction and reaching widespread adoption...
January 2017: IEEE Computer Graphics and Applications
https://www.readbyqxmd.com/read/28103518/adsorption-of-quinolone-tetracycline-and-penicillin-antibiotics-from-aqueous-solution-using-activated-carbons-review
#9
REVIEW
Muthanna J Ahmed
Antibiotics, an important type of pharmaceutical pollutant, have attracted many researchers to the study of their removal from aqueous solutions. Activated carbon (AC) has been widely used as highly effective adsorbent for antibiotics because of its large specific surface area, high porosity, and favorable pore size distribution. In this article, the adsorption performance of AC towards three major types of antibiotics such as tetracyclines, quinolones, and penicillins were reviewed. According to collected data, maximum adsorption capacities of 1340...
January 16, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28103489/enhanced-degradation-of-organic-contaminants-in-water-by-peroxydisulfate-coupled-with-bisulfite
#10
Chengdu Qi, Xitao Liu, Yang Li, Chunye Lin, Jun Ma, Xiaowan Li, Huijuan Zhang
In this study, the bisulfite-peroxydisulfate system (S(IV)/PDS) widely used in polymerization was innovatively applied for organic contaminants degradation in water. The addition of S(IV) into PDS system remarkably enhanced the degradation efficiency of bisphenol A (BPA, a frequently detected endocrine disrupting chemical in the environments) from 17.0% to 84.7% within 360 min. The degradation efficiency of BPA in the S(IV)/PDS system followed pseudo-first-order kinetics, with rate constant values ranging from 0...
January 10, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28103450/paper-based-analytical-devices-for-clinical-diagnosis-recent-advances-in-the-fabrication-techniques-and-sensing-mechanisms
#11
Mazhar Sher, Rachel Zhuang, Utkan Demirci, Waseem Asghar
There is a significant interest in developing inexpensive portable biosensing platforms for various applications including disease diagnostics, environmental monitoring, food safety, and water testing at the point-of-care (POC) settings. Current diagnostic assays available in the developed world require sophisticated laboratory infrastructure and expensive reagents. Hence, they are not suitable for resource-constrained settings with limited financial resources, basic health infrastructure, and few trained technicians...
January 19, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28103444/efficacy-and-safety-of-a-recombinant-factor-viii-produced-from-a-human-cell-line-simoctocog-alfa
#12
Massimo Franchini, Pier Mannuccio Mannucci
The development of inhibitors against infused factor VIII (FVIII) has a detrimental impact on health and quality of life of patients with hemophilia A. Several observational studies and a recently published randomized trial indicate that the inhibitor risk in previously untreated patients (PUPs) is higher following the use of recombinant FVIII (rFVIII) products compared with plasma-derived FVIII concentrates. There is currently a great interest towards newer rFVIII products that adopt various technological solutions to reduce the inhibitor risk...
January 19, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28103428/aqueous-biphasic-systems-for-the-synthesis-of-formates-via-catalytic-co2-hydrogenation-integrated-reaction-and-catalyst-separation-for-co2-scrubbing-solutions
#13
Martin Scott, Beatriz Blas Molinos, Christian Westhues, Giancarlo Franciò, Walter Leitner
Aqueous biphasic systems were investigated for the production of formate-amine-adducts via metal-catalyzed CO2-hydrogenation. Different hydrophobic organic solvents and ionic liquids could be employed as the stationary phase for cis-Ru(dppm)2Cl2 as prototypical catalyst without any modification or tagging of the complex. The solvent pair methyl-isobutylcarbinol (MIBC) and water led to the most practical and productive system and repetitive use of the catalyst phase was demonstrated achieving high endurance with a total TON 150...
January 19, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28103317/genetically-thermo-stabilised-immunogenic-poliovirus-empty-capsids-a-strategy-for-non-replicating-vaccines
#14
Helen Fox, Sarah Knowlson, Philip D Minor, Andrew J Macadam
While wild type polio has been nearly eradicated there will be a need to continue immunisation programmes for some time because of the possibility of re-emergence and the existence of long term excreters of poliovirus. All vaccines in current use depend on growth of virus and most of the non-replicating (inactivated) vaccines involve wild type viruses known to cause poliomyelitis. The attenuated vaccine strains involved in the eradication programme have been used to develop new inactivated vaccines as production is thought safer...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28103195/the-enhancement-of-nasal-drug-absorption-from-powder-formulations-by-the-addition-of-sodium-carboxymethyl-cellulose
#15
Akiko Tanaka, Tomoyuki Furubayashi, Hitomi Yamasaki, Katsuko Takano, Mayuko Kawakami, Shunsuke Kimura, Daisuke Inoue, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto
For nasal drug absorption, powder formulations can be expected to provide many advantages. The first aim of this study was to examine drug absorption following nasal administration of powder formulations in rats. Pharmaceutical excipients are typically added to most powder formulations. The second aim was to investigate the change in nasal drug absorption of powder formulations in the presence of sodium carboxymethyl cellulose (CMC-Na). Model drugs used were norfloxacin (NFX), warfarin (WF), and piroxicam (PXC)...
January 4, 2017: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/28103188/numerical-inversion-of-srnf-maps-for-elastic-shape-analysis-of-genus-zero-surfaces
#16
Hamid Laga, Qian Xie, Ian H Jermyn, Anuj Srivastava
Recent developments in elastic shape analysis (ESA) are motivated by the fact that it provides a comprehensive framework for simultaneous registration, deformation, and comparison of shapes. These methods achieve computational efficiency using certain square-root representations that transform invariant elastic metrics into Euclidean metrics, allowing for the application of standard algorithms and statistical tools. For analyzing shapes of embeddings of S2 in R3, Jermyn et al. [1] introduced square-root normal fields (SRNFs), which transform an elastic metric, with desirable invariant properties, into the L2 metric...
January 5, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28103187/convexity-shape-prior-for-binary-segmentation
#17
Lena Gorelick, Olga Veksler, Yuri Boykov, Claudia Nieuwenhuis
Convexity is a known important cue in human vision. We propose shape convexity as a new high-order regularization constraint for binary image segmentation. In the context of discrete optimization, object convexity is represented as a sum of three-clique potentials penalizing any 1- 0- 1 configuration on all straight lines. We show that these non-submodular potentials can be efficiently optimized using an iterative trust region approach. At each iteration the energy is linearly approximated and globally optimized within a small trust region around the current solution...
February 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28103165/burn-wound-healing-present-concepts-treatment-strategies-and-future-directions
#18
A Oryan, E Alemzadeh, A Moshiri
Burns are the most extensive forms of soft tissue injuries occasionally resulting in extensive and deep wounds and death. Burns can lead to severe mental and emotional distress, because of excessive scarring and skin contractures. Treatment of burns has always been a difficult medical problem and many different methods have been used to treat such injuries, locally. Biofilms are a collection of microorganisms that delay wound healing. One of the new methods of prevention and treatment of burn wound infections is application of antimicrobials, which act on biofilms and prevent the wound infection...
January 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28103121/comparison-of-helicopter-emergency-medical-services-transport-types-and-delays-on-patient-outcomes-at-two-level-i-trauma-centers
#19
Brodie Nolan, Homer Tien, Bruce Sawadsky, Sandro Rizoli, Amanda McFarlan, Andrea Phillips, Alun Ackery
BACKGROUND: Helicopter emergency medical services (HEMS) have become an engrained component of trauma systems. In Ontario, transportation for trauma patients is through one of three ways: scene call, modified scene call, or interfacility transfer. We hypothesize that differences exist between these types of transports in both patient demographics and patient outcomes. This study compares the characteristics of patients transported by each of these methods to two level 1 trauma centers and assesses for any impact on morbidity or mortality...
January 19, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28103060/a-new-algorithm-using-the-non-dominated-tree-to-improve-non-dominated-sorting
#20
Patrik Gustavsson, Anna Syberfeldt
Non-dominated sorting is a technique often used in evolutionary algorithms to determine the quality of solutions in a population. The most common algorithm is the Fast Non-dominated Sort (FNS). This algorithm, however, has the drawback that its performance deteriorates when the population size grows. The same drawback applies also to other non-dominating sorting algorithms such as the Efficient Non-dominated Sort with Binary Strategy (ENS-BS). An algorithm suggested to overcome this drawback is the Divide-and-Conquer Non-dominated Sort (DCNS) which works well on a limited number of objectives but deteriorates when the number of objectives grows...
January 19, 2017: Evolutionary Computation
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