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https://www.readbyqxmd.com/read/29050222/beneficial-effect-of-fluoxetine-treatment-aganist-psychological-stress-is-mediated-by-increasing-bdnf-expression-in-selected-brain-areas
#1
Gongying Li, Ping Jing, Zhidong Liu, Zhiruo Li, Hongxia Ma, Wenzhen Tu, Wei Zhang, Chuanjun Zhuo
SSRI antidepressant fluoxetine is widely used to treat psychological stress related disorders, however the underlying working mechanisms is not fully understood, as SSRIs can rapidly increase the extracellular serotonin levels but it normally takes weeks to reveal their therapeutic effect in the stress-related psychological disorders. Our previous study demonstrated that purely psychological stress without any physic stimuli induces a biphasic change in the expression of brain-derived neurotrophic factor (BDNF), which immediately decrease and then gradually increase after the stress; and that the latter BDNF increase in response to the psychological stress involves the activation of serotonin system...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050025/conventional-preventive-therapies-fluoride-on-root-caries-lesions
#2
Ana Carolina Magalhães
Root caries lesions (RCLs) are highly prevalent in elderly and can negatively impact the quality of life. Therefore, preventive therapies should be applied to control or to arrest RCLs. This chapter will discuss the application of fluoride, a conventional preventive therapy, to control RCLs. Among the self-applied products, there is strong evidence that 5,000 ppm F toothpaste is more effective in arresting RCLs (by increasing hardness) and in preventing new lesions (PF of 51%) compared to 1,100-1,450 ppm F toothpastes, in 6-month clinical trials...
2017: Monographs in Oral Science
https://www.readbyqxmd.com/read/29049988/magnolia-officinalis-bark-extract-induces-depolarization-of-pacemaker-potentials-through-m2-and-m3-muscarinic-receptors-in-cultured-murine-small-intestine-interstitial-cells-of-cajal
#3
Hyun Jung Kim, Taewon Han, Yun Tai Kim, Insuk So, Byung Joo Kim
BACKGROUND: Magnolia officinalis Rehder and EH Wilson (M. officinalis) are traditional Chinese medicines widely used for gastrointestinal (GI) tract motility disorder in Asian countries. We investigated the effects of an ethanol extract of M. officinalis (MOE) on the pacemaker potentials of cultured interstitial cells of Cajal (ICCs) in vitro and its effects on GI motor functions in vivo. METHODS: We isolated ICCs from small intestines, and the whole-cell patch-clamp configuration was used to record the pacemaker potentials in cultured ICCs in vitro...
October 19, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29049967/halogenated-fatty-amides-a-brand-new-class-of-disinfection-by-products
#4
Dmitry S Kosyakov, Nikolay V Ul'yanovskii, Mark S Popov, Tomas B Latkin, Albert T Lebedev
An array of similar halogenated nitrogen-containing compounds with elemental composition CnH2nNO2X, CnH2n-2NO2X and CnH2n-1NOX2 (X = Cl, Br; n = 16, 18, 22) was detected in drinking water with high performance liquid chromatography - high resolution mass spectrometry (HPLC-HRMS) method. Compounds of this type were never mentioned among disinfection by-products. Tandem mass spectrometry allowed referring them to halohydrines or dihalogenated fatty amides, the products of conjugated electrophilic addition of halogens to the double bonds of unsaturated fatty amides...
October 6, 2017: Water Research
https://www.readbyqxmd.com/read/29049956/adsorption-and-biodegradation-of-dye-in-wastewater-with-fe3o4-mil-100-fe-core-shell-bio-nanocomposites
#5
Jixiang Fan, Dongyun Chen, Najun Li, Qingfeng Xu, Hua Li, Jinghui He, Jianmei Lu
Adsorption and improved biodegradation of dyes in wastewater was achieved with Fe3O4@MIL-100 core-shell bio-nanocomposites, which were prepared by a step-by-step strategy and attached to the surface of bacteria via zero-length carbodiimide chemistry. The Fe3O4@MIL-100 (Fe) nano-composite showed excellent dye adsorption properties and the overall dye removal process followed second-order kinetics. The dye AO10 was completely eliminated from solution by the combined effects of adsorption and biodegradation within 15 and 25 h from initial dye concentrations of 25 and 50 mg/L, respectively...
October 10, 2017: Chemosphere
https://www.readbyqxmd.com/read/29049953/biomimetic-fabrication-of-antibacterial-calcium-phosphates-mediated-by-polydopamine
#6
Lucia Forte, Paola Torricelli, Francesca Bonvicini, Elisa Boanini, Giovanna Angela Gentilomi, Gigliola Lusvardi, Elena Della Bella, Milena Fini, Edoardo Vecchio Nepita, Adriana Bigi
In this work we developed new antibacterial composite materials using polydopamine (PDA) to trigger the deposition of silver nanoparticles (AgNPs) onto calcium phosphates, namely octacalcium phosphate (OCP) and α-tricalcium phosphate (αTCP). Functionalization of OCP and αTCP with a self-polymerized polydopamine layer was obtained by soaking the calcium phosphates in dopamine solution. The PDA surface of functionalized calcium phosphates (OCPd and αTCPd) promoted the deposition of AgNPs by reducing silver ions when soaked in a silver nitrate solution...
October 10, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29049942/bioaugmentation-of-thiabendazole-contaminated-soils-from-a-wastewater-disposal-site-factors-driving-the-efficacy-of-this-strategy-and-the-diversity-of-the-indigenous-soil-bacterial-community
#7
Evangelia S Papadopoulou, Savvas Genitsaris, Michalis Omirou, Chiara Perruchon, Anastasia Stamatopoulou, Ioannis Ioannides, Dimitrios G Karpouzas
The application of the fungicide thiabendazole (TBZ) in fruit packaging plants (FPP) results in the production of effluents which are often disposed in adjacent field sites. These require remediation to prevent further environmental dispersal of TBZ. We assessed the bioaugmentation potential of a newly isolated TBZ-degrading bacterial consortium in a naturally contaminated soil (NCS) exhibiting a natural gradient of TBZ levels (12000, 400, 250 and 12 mg kg(-1)). The effect of aging on bioaugmentation efficacy was comparatively tested in a soil with similar physicochemical properties and soil microbiota, which was artificially, contaminated with the same TBZ levels (ACS)...
October 16, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29049941/induced-structural-changes-of-humic-acid-by-exposure-of-polystyrene-microplastics-a-spectroscopic-insight
#8
Wei Chen, Zhen-Yu Ouyang, Chen Qian, Han-Qing Yu
The occurrence of microplastics (MPs) as emerging contaminants in the environment may cause changes in water or sediment characteristics, and further affect their biogeochemical cycles. Thus, insights into the interactions between dissolved organic matter (DOM) and MPs are essential for the assessment of environmental impacts of MPs in ecosystems. Integrating spectroscopic methods with chemometric analyses, this work explored the chemical and microstructural changes of DOM-MP complex to reveal the mechanism of DOM-MP interaction at a molecular level...
October 16, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29049871/a-table-top-pxi-based-low-field-spectrometer-for-solution-dynamic-nuclear-polarization
#9
Joshua R Biller, Karl F Stupic, J Moreland
We present the development of a portable dynamic nuclear polarization (DNP) instrument based on the PCI eXtensions for Instrumentation (PXI) platform. The main purpose of the instrument is for study of (1) H polarization enhancements in solution through the Overhauser mechanism at low magnetic fields. A DNP probe set was constructed for use at 6.7 mT, using a modified Alderman-Grant (MAG) resonator at 241 MHz for saturation of the electron transition. The solenoid for detection of the enhanced (1) H signal at 288 kHz was constructed with Litz wire...
October 19, 2017: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/29049870/dendrimers-breaking-the-paradigm-of-current-musculoskeletal-autoimmune-therapies
#10
REVIEW
Daniel B Rodrigues, Joaquim M Oliveira, Tírcia C Santos, Rui L Reis
The advances achieved by cell-based therapies to treat autoimmune diseases such as rheumatoid arthritis (RA) and multiple sclerosis (MS), despite promising, are still insufficient for the current demands. RA and MS therapeutic approaches follow world guidelines to use disease modifying drugs and biological agents which, regardless of some good results in clinical outcomes, are well known for several systemic secondary side effects. Dendrimers are custom-made nanoparticles with proved clinical potential, displaying proper size, chemistries, immunomodulatory and anti-inflammatory properties...
October 19, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29049743/additional-veno-venous-gas-exchange-as-a-problem-solving-strategy-for-an-oxygenator-not-transferring-oxygen-in-paediatric-cardiopulmonary-bypass
#11
Wolfgang Boettcher, Nicodème Sinzobahamvya, Frank Dehmel, Andreas Matschke, Andre Iben, Mi-Young Cho, Mathias Redlin, Joachim Photiadis
OBJECTIVES: Oxygenator failure during cardiopulmonary bypass constitutes a life-threatening event, especially when perfusion is conducted under normothermia. An alternative solution to emergency oxygenator changeover is described. METHODS: A supplementary oxygenator is added in the venous line without interrupting perfusion. De-airing is achieved through the cardiotomy reservoir. Oxygen supply is adapted to ensure physiologic partial oxygen pressure. RESULTS: On 5 occasions in the past 4 years, Capiox Baby FX 05 oxygenator ( n  = 4) and Capiox FX15 ( n  = 1) failed to exchange blood gases after bypass run ranging from 290 min to 563 min...
June 20, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049705/follow-up-of-a-simple-method-for-aortic-valve-reconstruction-with-fixed-pericardium-in-children
#12
Amir-Reza Hosseinpour, Alejandro Adsuar-Gómez, Antonio González-Calle, Antonio Moruno-Tirado, Francisco García-Angleu, Israel Valverde, Felix Coserria-Sánchez, Begoña Manso-García
In 2013, we published a simple method for aortic valve reconstruction in children using fixed pericardium in this journal. This was not expected to be a durable solution but a temporizing measure in the absence of other solutions, in order to buy time for growth that would allow subsequent prosthetic valve insertion. As such, this was implemented in 3 patients with excellent immediate results, as reported in our original publication. We are now writing to provide longer term information. In 2 cases, a newborn and a 12-year-old boy, the valve calcified heavily at 4 years' follow-up...
July 21, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049542/nanoparticle-optimization-for-enhanced-targeted-anti-cancer-drug-delivery
#13
Ibrahim Chamseddine, Michael Kokkolaras
Nanoparticle-based drug delivery is a promising method to increase the therapeutic index of anti-cancer agents with low median toxic dose. The delivery efficiency, corresponding to the fraction of the injected nanoparticles that adhere to the tumor site, depends on nanoparticle size $a$ and aspect ratio $AR$. Currently, values for these variables are chosen empirically, and may not yield optimal targeted drug delivery. This study applies rigorous optimization to the design of nanoparticles. A preliminary investigation revealed that delivery efficiency increases monotonically with $a$ and $AR$...
October 16, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29049392/multiple-co-clustering-based-on-nonparametric-mixture-models-with-heterogeneous-marginal-distributions
#14
Tomoki Tokuda, Junichiro Yoshimoto, Yu Shimizu, Go Okada, Masahiro Takamura, Yasumasa Okamoto, Shigeto Yamawaki, Kenji Doya
We propose a novel method for multiple clustering, which is useful for analysis of high-dimensional data containing heterogeneous types of features. Our method is based on nonparametric Bayesian mixture models in which features are automatically partitioned (into views) for each clustering solution. This feature partition works as feature selection for a particular clustering solution, which screens out irrelevant features. To make our method applicable to high-dimensional data, a co-clustering structure is newly introduced for each view...
2017: PloS One
https://www.readbyqxmd.com/read/29049382/reaching-the-end-of-the-line-operational-issues-with-implementing-phone-based-unannounced-pill-counts-in-resource-limited-settings
#15
Yael Hirsch-Moverman, Camilla Burkot, Suzue Saito, Koen Frederix, Blanche Pitt, Zenebe Melaku, Tsigereda Gadisa, Andrea A Howard
INTRODUCTION: Accurate measurement of adherence is necessary to ensure that therapeutic outcomes can be attributed to the recommended treatment. Phone-based unannounced pill counts were shown to be feasible and reliable measures of adherence in developed settings; and have been further used as part of medication adherence interventions. However, it is not clear whether this method can be implemented successfully in resource-limited settings, where cellular network and mobile phone coverage may be low...
2017: PloS One
https://www.readbyqxmd.com/read/29049335/structural-prediction-of-two-novel-human-atypical-slc-transporters-mfsd4a-and-mfsd9-and-their-neuroanatomical-distribution-in-mice
#16
Emelie Perland, Sofie Victoria Hellsten, Nadine Schweizer, Vasiliki Arapi, Fatemah Rezayee, Mona Bushra, Robert Fredriksson
Out of the 430 known solute carriers (SLC) in humans, 30% are still orphan transporters regarding structure, distribution or function. Approximately one third of all SLCs belong to the evolutionary conserved and functionally diverse Major Facilitator Superfamily (MFS). Here, we studied the orphan proteins, MFSD4A and MFSD9, which are atypical SLCs of MFS type. Hidden Markov Models were used to identify orthologues in several vertebrates, and human MFSD4A and MFSD9 share high sequence identity with their identified orthologues...
2017: PloS One
https://www.readbyqxmd.com/read/29049280/ethoscopes-an-open-platform-for-high-throughput-ethomics
#17
Quentin Geissmann, Luis Garcia Rodriguez, Esteban J Beckwith, Alice S French, Arian R Jamasb, Giorgio F Gilestro
Here, we present the use of ethoscopes, which are machines for high-throughput analysis of behavior in Drosophila and other animals. Ethoscopes provide a software and hardware solution that is reproducible and easily scalable. They perform, in real-time, tracking and profiling of behavior by using a supervised machine learning algorithm, are able to deliver behaviorally triggered stimuli to flies in a feedback-loop mode, and are highly customizable and open source. Ethoscopes can be built easily by using 3D printing technology and rely on Raspberry Pi microcomputers and Arduino boards to provide affordable and flexible hardware...
October 2017: PLoS Biology
https://www.readbyqxmd.com/read/29049210/topical-use-of-tranexamic-acid-can-effectively-decrease-hidden-blood-loss-during-posterior-lumbar-spinal-fusion-surgery-a-retrospective-study
#18
Zhinan Ren, Shugang Li, Lin Sheng, Qianyu Zhuang, Zheng Li, Derong Xu, Xin Chen, Pengxiang Jiang, Xiao Zhang
In spinal fusion surgery, total blood loss (TBL) is composed of visible blood loss from the surgical field and wound drainage, and hidden blood loss (HBL). Until now, no published studies exist reporting the effect of topical use of tranexamic acid (tTXA) on HBL in patients undergoing posterior lumbar spinal fusion surgery. This study aimed to explore the effect of tTXA on HBL during primary posterior lumbar spinal fusion surgery. Between September 2014 and September 2016, 100 adult patients (age > 18 years) with lumbar disc herniation or lumbar spinal stenosis undergoing primary posterior lumbar instrumented spinal fusions at 1 institution were divided into tTXA and control groups...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049112/america-s-opioid-epidemic-supply-and-demand-considerations
#19
David J Clark, Mark A Schumacher
America is in the midst of an opioid epidemic characterized by aggressive prescribing practices, highly prevalent opioid misuse, and rising rates of prescription and illicit opioid overdose-related deaths. Medical and lay public sentiment have become more cautious with respect to prescription opioid use in the past few years, but a comprehensive strategy to reduce our reliance on prescription opioids is lacking. Addressing this epidemic through reductions in unnecessary access to these drugs while implementing measures to reduce demand will be important components of any comprehensive solution...
November 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29049075/insight-into-our-technology-anesthesia-information-management-systems
#20
Allan F Simpao, Mohamed A Rehman
Anesthesia information management systems (AIMS) have evolved from simple, automated intraoperative record keepers in a select few institutions to widely adopted, sophisticated hardware and software solutions that are integrated into a hospital's electronic health record system and used to manage and document a patient's entire perioperative experience. AIMS implementations have resulted in numerous billing, research, and clinical benefits, yet there remain challenges and areas of potential improvement to AIMS utilization...
October 17, 2017: Anesthesia and Analgesia
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