keyword
https://read.qxmd.com/read/36657239/coupling-elisa-to-smartphones-for-poct-of-chronic-and-congenital-chagas-disease
#21
JOURNAL ARTICLE
Federico Schaumburg, Nazarena Pujato, Luz María Peverengo, Iván Sergio Marcipar, Claudio Luis Alberto Berli
Chagas disease (CD) affects about 7 million people worldwide, presents a large prevalence in Latin America, and is growing in the rest of the world, where congenital CD is the main mode of transmission. Point-of-care testing (POCT) methods are increasingly required to ease early diagnostics and increase treatment success. This work presents the development and validation of a smartphone-integrated ELISA-based POCT system for the detection of both chronic and congenital CD. Expensive and bulky equipment used for ELISA in conventional laboratories was replaced as follows...
January 5, 2023: Talanta
https://read.qxmd.com/read/36584322/assessment-of-fetal-heart-aortic-and-pulmonary-valve-annulus-area-by-three-dimensional-ultrasonography-reference-curves-and-applicability-in-congenital-heart-diseases
#22
JOURNAL ARTICLE
Caroline Cervante Chagas, Ana Letícia Siqueira Pontes, Nathalie Jeanne Bravo-Valenzuela, Alberto Borges Peixoto, Ilenia Mappa, Clementina Viscardi, Giuseppe Rizzo, Edward Araujo Júnior
OBJECTIVES: To determine reference curves for fetal aortic and pulmonary valve annulus area by three-dimensional ultrasonography using the spatio-temporal image correlation (STIC) in the rendering mode, and to ascertain its applicability in congenital heart disease (CHD). METHODS: We performed a retrospective cross-sectional study of 328 normal fetuses and 42 fetuses with CHD between 20 and 33 weeks 6 days of gestation. The outflow plane view of the great vessels was used to measure the areas of the valvar annuli, and the measurements were performed in systole...
January 2, 2023: Journal of Perinatal Medicine
https://read.qxmd.com/read/36565805/effects-of-acute-and-chronic-trypanosoma-cruzi-infection-on-pregnancy-outcomes-in-mice-parasite-transmission-mortality-delayed-growth-and-organ-damage-in-pups
#23
JOURNAL ARTICLE
Lizette Elaine Rios, Nandadeva Lokugamage, Nisha Jain Garg
Chagas disease is caused by Trypanosoma cruzi. This study aimed to determine the effects of T. cruzi infection on fertility rate and health of the newborn pups in pregnant mice. Female mice were challenged with T. cruzi and mated at 21-days (acute parasitemic phase) or 90-days (chronic parasite persistence phase) post-infection. Pups were examined for growth up to 20-days post-birth and parasite burden in brain, heart, skeletal muscle, and intestine was measured by qPCR. The inflammatory infiltrate, necrosis, and fibrosis in pups' heart and brain tissues were evaluated by histology...
December 21, 2022: American Journal of Pathology
https://read.qxmd.com/read/36490362/kidney-pathology-of-tropical-and-nontropical-infectious-diseases-in-the-pediatric-population
#24
JOURNAL ARTICLE
Morgan Williams, Jenna Reisler, Tyler James, Marjan Afrouzian
OBJECTIVES: To review kidney pathology of tropical and nontropical infectious diseases in the pediatric population. METHODS: We review 4 tropical and 2 nontropical infectious diseases that affect the kidneys of children in terms of their direct and indirect pathogenetic mechanism in inducing kidney damage. RESULTS: We demonstrate clinical manifestations, pathogenesis, kidney pathology, and laboratory diagnostic methods for (1) renal cryptococcosis, which represents involvement of a pure direct pathway; (2) schistosomiasis and dengue fever as examples of dual direct and indirect pathways; and (3) congenital syphilis, visceral leishmaniasis, and Chagas disease, which represent indirect pathways...
December 9, 2022: American Journal of Clinical Pathology
https://read.qxmd.com/read/36395748/diagnosis-of-acute-chagas-disease-in-a-belizean-child-with-evidence-of-a-multiclonal-trypanosoma-cruzi-infection
#25
Kristy O Murray, Miguel A Saldaña, Sarah M Gunter, Russell Manzanero, Emily Zielinski-Gutierrez, Claudia Herrera, Julie M Thompson, Adrianna Maliga, Kim Bautista, Allison Lino, Ella Hawes, Shannon E Ronca, Francis Morey, Rafael Chacon Fuentes, Beatriz Lopez, Eric Dumonteil, Gerhaldine H Morazan
In January 2020, we instituted acute febrile illness surveillance in 11 hospitals and clinics across Belize. Within 3 months, we diagnosed an acute case of Chagas disease by polymerase chain reaction in a 7-year-old child in the northern part of the country. Phylogenetic analyses of the parasite from the acute blood specimen revealed a multiclonal Trypanosoma cruzi infection, including parasites from the TcII (25.0% of haplotypes), TcIV (2.5% of haplotypes), and TcV (72.5% of haplotypes) discrete typing units...
November 14, 2022: American Journal of Tropical Medicine and Hygiene
https://read.qxmd.com/read/36342961/estimation-of-the-morbidity-and-mortality-of-congenital-chagas-disease-a-systematic-review-and-meta-analysis
#26
JOURNAL ARTICLE
Sarah Matthews, Ayzsa Tannis, Karl Philipp Puchner, Maria Elena Bottazzi, Maria Luisa Cafferata, Daniel Comandé, Pierre Buekens
Chagas disease is caused by the parasite Trypanosoma cruzi which can be transmitted from mother to baby during pregnancy. There is no consensus on the proportion of infected infants with clinical signs of congenital Chagas disease (cCD). The objective of this systematic review is to determine the burden of cCD. Articles from journal inception to 2020 reporting morbidity and mortality associated with cCD were retrieved from academic search databases. Observational studies, randomized-control trials, and studies of babies diagnosed with cCD were included...
November 2022: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/36334212/fetal-heart-foramen-ovale-area-by-three-dimensional-ultrasound-using-stic-in-the-rendering-mode-reference-range-and-applicability-in-congenital-heart-diseases
#27
JOURNAL ARTICLE
Ana Letícia Siqueira Pontes, Caroline Cervantes Chagas, Nathalie Jeanne Bravo-Valenzuela, Alberto Borges Peixoto, Ilenia Mappa, Giuseppe Rizzo, Gabriele Tonni, Edward Araujo Júnior
To determine reference values for the foramen ovale (FO) area of fetal hearts by three-dimensional (3D) ultrasound using spatio-temporal image correlation (STIC) method in the rendering mode, as well as applicability in fetuses with congenital heart disease (CHD). A retrospective and prospective study was performed of 242 normal fetuses and 36 fetuses with CHD between 20 and 33 + 6 weeks of gestation. The FO area was determined in the four-chamber view with manual delineation. To determine the reference curve of the FO area as a function of gestational age (GA), a linear regression model was utilized with an adjusted coefficient of determination (R2 )...
November 5, 2022: International Journal of Cardiovascular Imaging
https://read.qxmd.com/read/36297229/animal-models-of-trypanosoma-cruzi-congenital-transmission
#28
REVIEW
Eduardo E Avalos-Borges, Lizette E Rios, Matilde Jiménez-Coello, Antonio Ortega-Pacheco, Nisha J Garg
Chagas disease, initiated by the etiological agent Trypanosoma cruzi , is an endemic infection in the American continent. Although vectorial transmission of T. cruzi is recognized as the main mode of infection, other routes such as congenital and blood transfusion are also documented as important methods of transmission. T. cruzi maternal-fetal transmission has been recorded in humans and examined by some investigators in naturally and experimentally infected mammals. Dogs are recognized as the major reservoir host in maintaining the domestic transmission of T...
October 11, 2022: Pathogens
https://read.qxmd.com/read/36190410/parasitemia-levels-in-trypanosoma-cruzi-infection-in-spain-an-area-where-the-disease-is-not-endemic-trends-by-different-molecular-approaches
#29
JOURNAL ARTICLE
Maria D Flores-Chavez, Alba Abras, Cristina Ballart, Ismael Ibáñez-Perez, Pilar Perez-Gordillo, Montserrat Gállego, Carmen Muñoz, Zaira Moure, Elena Sulleiro, Javier Nieto, Emilia García Diez, Lorena Simón, Israel Cruz, Albert Picado
Trypanosoma cruzi infection has expanded globally through human migration. In Spain, the mother-to-child route is the mode of transmission contributing to autochthonous Chagas disease (CD); however, most people acquired the infection in their country of origin and were diagnosed in the chronic phase (imported chronic CD). In this context, we assessed the quantitative potential of the Loopamp Trypanosoma cruzi detection kit (Sat-TcLAMP) based on satellite DNA (Sat-DNA) to determine parasitemia levels compared to those detected by real-time quantitative PCRs (qPCRs) targeting Sat-DNA (Sat-qPCR) and kinetoplast DNA minicircles (kDNA-qPCR)...
October 3, 2022: Microbiology Spectrum
https://read.qxmd.com/read/35951245/chronic-chagas-disease-the-potential-role-of-reinfections-in-cardiomyopathy-pathogenesis
#30
REVIEW
Christian Olivo Freites, Hendrik Sy, Amal Gharamti, Nelson I Agudelo Higuita, Carlos Franco-Paredes, José Antonio Suárez, Andrés F Henao-Martínez
PURPOSE OF THE REVIEW: Chagas disease is a neglected anthropozoonosis of global importance with significant cardiovascular-associated mortality. This review focuses on the Trypanosoma cruzi reinfections' role in chronic Chagas cardiomyopathy pathogenesis. We discuss and summarize the available data related to pathology, pathogenesis, diagnosis, and treatment of reinfections. RECENT FINDINGS: Reinfections influence the genetic and regional diversity of T. cruzi, tissue tropism, modulation of the host's immune system response, clinical manifestations, the risk for congenital infections, differences in diagnostics performances, response to antiparasitic therapy, and the natural history of the disease...
August 11, 2022: Current Heart Failure Reports
https://read.qxmd.com/read/35766782/chagas-disease-affects-the-human-placental-barrier-s-turnover-dynamics-during-pregnancy
#31
JOURNAL ARTICLE
Luciana Mezzano, Joana Paola Morán, María José Moreira-Espinoza, María Fernanda Triquell, Julieta Mezzano, Cintia María Díaz-Luján, Ricardo Emilio Fretes
BACKGROUND: Trypanosoma cruzi crosses the placental barrier and produces the congenital transmission of Chagas disease (CD). Structural alterations of the chorionic villi by this parasite have been described in vitro, but little is known about trophoblast turnover in placentas from women with CD. OBJECTIVE: To analyze the proliferation and fusion processes in placentas from women with CD. METHODS: Archived human term placenta paraffin-embedded blocks were used, from women with CD (CDP), and no pathology (NP)...
2022: Memórias do Instituto Oswaldo Cruz
https://read.qxmd.com/read/35731040/updated-estimates-and-mapping-for-prevalence-of-chagas-disease-among-adults-united-states
#32
REVIEW
Amanda Irish, Jeffrey D Whitman, Eva H Clark, Rachel Marcus, Caryn Bern
We combined American Community Survey data with age-specific Trypanosoma cruzi prevalence derived from US surveys and World Health Organization reports to yield estimates of Chagas disease in the United States, which we mapped at the local level. In addition, we used blood donor data to estimate the relative prevalence of autochthonous T. cruzi infection. Our estimates indicate that 288,000 infected persons, including 57,000 Chagas cardiomyopathy patients and 43,000 infected reproductive-age women, currently live in the United States; 22-108 congenital infections occur annually...
July 2022: Emerging Infectious Diseases
https://read.qxmd.com/read/35688417/family-cluster-of-chagas-disease-among-bolivian-immigrants-in-italy-high-rate-of-materno-fetal-transmission
#33
JOURNAL ARTICLE
Spinello Antinori, Laura Galimberti, Romualdo Grande, Davide Ricaboni, Stefania Sala, Vania Giacomet, Valeria Colombo, Mario Corbellino, Andrea Angheben, Andrea Giacomelli, Anna Lisa Ridolfo
BACKGROUND: Chagas disease (CD) or American trypanosomiasis is a neglected anthropozoonosis caused by Trypanosoma cruzi that affects 6-8 million people worldwide (mainly in Latin America), 30-40% of whom develop cardiac or digestive complications. Once confined to endemic areas of Latin America, CD has more recently become a global disease as a result of migration flows from endemic to non-endemic regions, particularly in northern America and Europe. Congenital transmission is a particular challenge as it may be sustained for multiple generations and perpetuate the infection even in non-endemic countries...
June 7, 2022: Travel Medicine and Infectious Disease
https://read.qxmd.com/read/35613155/parasitological-serological-and-molecular-diagnosis-of-acute-and-chronic-chagas-disease-from-field-to-laboratory
#34
JOURNAL ARTICLE
Alejandro Gabriel Schijman, Julio Alonso-Padilla, Silvia Andrea Longhi, Albert Picado
There is no consensus on the diagnostic algorithms for many scenarios of Trypanosoma cruzi infection, which hinders the establishment of governmental guidelines in endemic and non-endemic countries. In the acute phase, parasitological methods are currently employed, and standardised surrogate molecular tests are being introduced to provide higher sensitivity and less operator-dependence. In the chronic phase, IgG-based serological assays are currently used, but if a single assay does not reach the required accuracy, PAHO/WHO recommends at least two immunological tests with different technical principles...
2022: Memórias do Instituto Oswaldo Cruz
https://read.qxmd.com/read/35584508/emerging-and-reemerging-forms-of-trypanosoma-cruzi-transmission
#35
JOURNAL ARTICLE
Maria Aparecida Shikanai Yasuda
This review aims to update and discuss the main challenges in controlling emergent and reemergent forms of Trypanosoma cruzi transmission through organ transplantation, blood products and vertical transmission in endemic and non-endemic areas as well as emergent forms of transmission in endemic countries through contaminated food, currently representing the major cause of acute illness in several countries. As a neglected tropical disease potentially controllable with a major impact on morbimortality and socioeconomic aspects, Chagas disease (CD) was approved at the WHO global plan to interrupt four transmission routes by 2030 (vector/blood transfusion/organ transplant/congenital)...
2022: Memórias do Instituto Oswaldo Cruz
https://read.qxmd.com/read/35522804/the-cuida-chagas-project-towards-the-elimination-of-congenital-transmission-of-chagas-disease-in-bolivia-brazil-colombia-and-paraguay
#36
JOURNAL ARTICLE
Andréa Silvestre de Sousa, Debbie Vermeij, Gabriel Parra-Henao, Vidalia Lesmo, Evelin Fortún Fernández, José Jorge Chura Aruni, Fernanda de Souza Nogueira Sardinha Mendes, Laura C Bohorquez, Alejandro O Luquetti
BACKGROUND: Mother-to-child transmission of Chagas disease (CD) has become a relevant problem in both endemic and non-endemic areas. METHODS: Description of the CUIDA Chagas Project - Communities United for Innovation, Development and Attention for Chagas disease'. RESULTS: Through innovative and strategic research, this project will provide improved diagnostic and treatment options as well as replicable implementation models that are adaptable to different contexts...
2022: Revista da Sociedade Brasileira de Medicina Tropical
https://read.qxmd.com/read/35389951/emergence-of-congenital-chagas-disease-in-ireland
#37
JOURNAL ARTICLE
Roy G Stone, Patrick Gavin, Peter Chiodini, Debbie Nolder, Padraig McGettrick, Anna Keogh, Noel Mc Entagart, Richard Drew, Jack Lambert, Wendy Ferguson
Chagas disease (CD) is an under-diagnosed tropical disease that is increasingly being observed outside of Latin America. We describe the first 2 infants with congenital Chagas Disease (cCD) in Ireland. Clinicians in nonendemic countries need to be aware of the potential for cCD due to the migration of women from countries of high prevalence.
July 1, 2022: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/35335694/-calomys-callosus-an-experimental-animal-model-applied-to-parasitic-diseases-investigations-of-public-health-concern
#38
REVIEW
Rafael Borges Rosa, Mylla Spirandelli da Costa, Samuel Cota Teixeira, Emilene Ferreira de Castro, Willyenne Marília Dantas, Eloisa Amália Vieira Ferro, Murilo Vieira da Silva
The appearance and spread of parasitic diseases around the world aroused the interest of the scientific community to discover new animal models for improving the quality and specificity of surveys. Calomys callosus is a rodent native to South America, an easy handling model, with satisfactory longevity and reproducibility. C. callosus is susceptible to toxoplasmosis and can be used as experimental model for the study the pathogenesis, treatment, vertical transmission, and ocular toxoplasmosis. C. callosus can also be used to study cutaneous and visceral leishmaniasis, as the animals present cutaneous lesions, as well as parasites in the organs...
March 17, 2022: Pathogens
https://read.qxmd.com/read/35335686/ex-vivo-infection-of-human-placental-explants-by-trypanosoma-cruzi-reveals-a-microrna-profile-similar-to-that-seen-in-trophoblast-differentiation
#39
JOURNAL ARTICLE
Lisvaneth Medina, Jesús Alejandro Guerrero-Muñoz, Ana Isabel Liempi, Christian Castillo, Yessica Ortega, Alfredo Sepúlveda, Fernando Salomó, Juan Diego Maya, Ulrike Kemmerling
Congenital Chagas disease, caused by the protozoan parasite Trypanosoma cruzi , is responsible for 22.5% of new cases each year. However, placental transmission occurs in only 5% of infected mothers and it has been proposed that the epithelial turnover of the trophoblast can be considered a local placental defense against the parasite. Thus, Trypanosoma cruzi induces cellular proliferation, differentiation, and apoptotic cell death in the trophoblast, which are regulated, among other mechanisms, by small non-coding RNAs such as microRNAs...
March 16, 2022: Pathogens
https://read.qxmd.com/read/35082900/aleatory-trypanosoma-cruzi-vertical-transmission-in-chiapas-mexico-a-case-report
#40
Sury Antonio López-Cancino, Jorge Fernando Méndez-Galván, Mariana Soria-Guerrero, Marcos Meneses-Mayo, Sergio Agustin Islas-Andrade, Enedina Jiménez-Cardoso
Congenital Chagas disease is considered a form of dispersion of Trypanosoma cruzi related to human migration from endemic, often rural to previously non-endemic urban areas. This fact increases the Chagas disease establishment risk inside of family members by vertical transmission pathway. Congenital Chagas disease cases in newborns could not identified by the health professional even in endemic regions. Here we present the first family cluster of Chagas disease cases from Chiapas: one of the most important endemic areas in South of Mexico, where vertical T...
October 2021: Iranian Journal of Parasitology
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