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Chagas disease congenital

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https://www.readbyqxmd.com/read/28892479/towards-chagas-disease-elimination-neonatal-screening-for-congenital-transmission-in-rural-communities
#1
Pamela Marie Pennington, José Guillermo Juárez, Margarita Rivera Arrivillaga, Sandra María De Urioste-Stone, Katherine Doktor, Joe P Bryan, Clara Yaseli Escobar, Celia Cordón-Rosales
Chagas disease is a neglected tropical disease that continues to affect populations living in extreme poverty in Latin America. After successful vector control programs, congenital transmission remains as a challenge to disease elimination. We used the PRECEDE-PROCEED planning model to develop strategies for neonatal screening of congenital Chagas disease in rural communities of Guatemala. These communities have persistent high triatomine infestations and low access to healthcare. We used mixed methods with multiple stakeholders to identify and address maternal-infant health behaviors through semi-structured interviews, participatory group meetings, archival reviews and a cross-sectional survey in high risk communities...
September 11, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28820896/a-strategy-for-scaling-up-access-to-comprehensive-care-in-adults-with-chagas-disease-in-endemic-countries-the-bolivian-chagas-platform
#2
Maria-Jesus Pinazo, Jimy Pinto, Lourdes Ortiz, Jareth Sánchez, Wilson García, Ruth Saravia, Mirko-R Cortez, Silvia Moriana, Enric Grau, Daniel Lozano, Joaquim Gascon, Faustino Torrico
BACKGROUND: Bolivia has the highest prevalence of Chagas disease (CD) in the world (6.1%), with more than 607,186 people with Trypanosoma cruzi infection, most of them adults. In Bolivia CD has been declared a national priority. In 2009, the Chagas National Program (ChNP) had neither a protocol nor a clear directive for diagnosis and treatment of adults. Although programs had been implemented for congenital transmission and for acute cases, adults remained uncovered. Moreover, health professionals were not aware of treatment recommendations aimed at this population, and research on CD was limited; it was difficult to increase awareness of the disease, understand the challenges it presented, and adapt strategies to cope with it...
August 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28777208/survey-of-pediatric-infectious-diseases-society-members-about-congenital-chagas-disease
#3
Morven S Edwards, Francisca A Abanyie, Susan P Montgomery
Participants in a survey about congenital Chagas disease, distributed electronically to Pediatric Infectious Diseases Society members, perceived having limited knowledge about congenital Trypanosoma cruzi infection. Most rarely or never consider the diagnosis in infants born to parents from Latin America. Improved awareness of congenital Chagas disease and assessment of at-risk infants is needed.
August 1, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28727985/comparative-study-and-analytical-verification-of-pcr-methods-for-the-diagnosis-of-congenital-chagas-disease
#4
Carolina Inés Cura, Juan Carlos Ramírez, Marcelo Rodríguez, Constanza Lopez-Albízu, Lucía Irazu, Karenina Scollo, Sergio Sosa-Estani
Congenital infection is currently the first cause of new cases of Chagas disease in Argentina and nonendemic areas worldwide. Its diagnosis is of utmost importance to guarantee curative treatment. To improve such diagnosis, a transfer process of PCR tests to the national laboratory network has been initiated. We performed a comparative study of four PCR assays [two end-point PCR and two duplex real-time quantitative PCR (qPCR) procedures] to detect Trypanosoma cruzi DNA in blood samples. Because satellite DNA and kinetoplastid DNA qPCR methods have the best performance and the use of two different molecular targets for confirmatory purposes has been recommended, these methods selected to perform the transfer process and, in consequence, subjected to an analytical verification protocol based on international guidelines...
July 17, 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/28727723/analytical-sensitivity-and-specificity-of-a-loop-mediated-isothermal-amplification-lamp-kit-prototype-for-detection-of-trypanosoma-cruzi-dna-in-human-blood-samples
#5
Susana A Besuschio, Mónica Llano Murcia, Alejandro F Benatar, Severine Monnerat, Israel Cruz, Albert Picado, María de Los Ángeles Curto, Yutaka Kubota, Diana P Wehrendt, Paula Pavia, Yasuyoshi Mori, Concepción Puerta, Joseph M Ndung'u, Alejandro G Schijman
This study aimed to assess analytical parameters of a prototype LAMP kit that was designed for detection of Trypanosoma cruzi DNA in human blood. The prototype is based on the amplification of the highly repetitive satellite sequence of T.cruzi in microtubes containing dried reagents on the inside of the caps. The reaction is carried out at 65°C during 40 minutes. Calcein allows direct detection of amplified products with the naked eye. Inclusivity and selectivity were tested in purified DNA from Trypanosoma cruzi stocks belonging to the six discrete typing units (DTUs), in DNA from other protozoan parasites and in human DNA...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28720492/prevention-of-congenital-chagas-disease-by-benznidazole-treatment-in-reproductive-age-women-an-observational-study
#6
María G Álvarez, Carlos Vigliano, Bruno Lococo, Graciela Bertocchi, Rodolfo Viotti
Since the decline in new cases of infection by insect/vector, congenital Chagas disease has become more relevant in the transmission of Chagas disease. Treatment with benznidazole significantly reduces the parasitemia, which constitutes an important factor linked to vertical transmission. The objective of this study was to evaluate whether treatment with benznidazole previously administered to women of childbearing age can prevent or reduce the incidence of new cases of congenital Chagas disease. An historical cohort study that included all women in reproductive age (15-45 years) assisted in our center was designed...
October 2017: Acta Tropica
https://www.readbyqxmd.com/read/28582629/molecular-diagnostics-for-chagas-disease-up-to-date-and-novel-methodologies
#7
Julio Alonso-Padilla, Montserrat Gallego, Alejandro G Schijman, Joaquim Gascon
Chagas disease is caused by the parasite Trypanosoma cruzi. It affects 7 million people, mainly in Latin America. Diagnosis is usually made serologically, but at some clinical scenarios serology cannot be used. Then, molecular detection is required for early detection of congenital transmission, treatment response follow up, and diagnosis of immune-suppression reactivation. However, present tests are technically demanding and require well-equipped laboratories which make them unfeasible in low-resources endemic regions...
July 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28500812/the-prevalence-of-chagas-disease-among-latin-american-immigrants-with-pacemakers-in-los-angeles-california
#8
Sandy Park, Daniel R Sanchez, Mahmoud I Traina, Jason S Bradfield, Salvador Hernandez, Alvaro Joaquin Altamirano Ufion, Jalal Dufani, Patrick Bergin, Robin Y Wachsner, Sheba K Meymandi
AbstractChagas disease (CD), with associated conduction abnormalities, is a common indication for pacemaker implantation in Latin America. The prevalence of CD in Latin American immigrants with pacemakers residing in the United States has never been studied. This single-center cross-sectional study included pacemaker patients who were aged 18 years or more with a previous residence in Latin America for at least 6 months. Patients with an implantable cardioverter-defibrillator, cardiac resynchronization therapy, or iatrogenic and/or congenital heart block were excluded...
May 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28443980/chagas-disease-national-survey-of-seroprevalence-in-children-under-five-years-of-age-conducted-in-2008
#9
Graciela Russomando, Blanca Cousiño, Zunilda Sanchez, Laura X Franco, Eva M Nara, Lilian Chena, Magaly Martínez, María E Galeano, Lucio Benitez
BACKGROUND: Since the early 1990s, programs to control Chagas disease in South America have focused on eradicating domiciliary Triatoma infestans, the main vector. Seroprevalence studies of the chagasic infection are included as part of the vector control programs; they are essential to assess the impact of vector control measures and to monitor the prevention of vector transmission. OBJECTIVE: To assess the interruption of domiciliary vector transmission of Chagas disease by T...
May 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28435013/modeling-chagas-disease-in-chile-from-vector-to-congenital-transmission
#10
Mauricio Canals, Dante Cáceres, Sergio Alvarado, Andrea Canals, Pedro E Cattan
Chagaś disease is a human health problem in Latin America. It is highly prevalent in northern Chile between the Arica-Parinacota and Coquimbo regions, with reported incidence of 3-11/100000 inhabitants and mortality of 0.3-0.4/100000. The interruption of vector transmission was reported in 1999 by means of the elimination of the primary vector, Triatoma infestans, from human dwellings, thus the epidemiologic dynamics of this disease should be modified. Here we model the dynamics of Chagaś disease based on previous models for vector and congenital transmission, propose a model that includes both transmission forms and perform simulations...
April 20, 2017: Bio Systems
https://www.readbyqxmd.com/read/28428122/challenges-in-the-management-of-chagas-disease-in-latin-american-migrants-in-europe
#11
REVIEW
B Monge-Maillo, R López-Vélez
Chagas disease is endemic in Latin America. Due to migration the infection has crossed borders and it is estimated that 68,000-120,000 people with Chagas disease are currently living in Europe and 30% of them may develop visceral involvement. However, up to 90% of Chagas disease cases in Europe remain undiagnosed. The challenges which have to be overcome in Chagas disease in non-endemic countries are focused on related downing barriers to health care access, and related to screening, diagnostic tools and therapeutic management...
April 17, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28419477/the-effectiveness-of-riboflavin-and-ultraviolet-light-pathogen-reduction-technology-in-eliminating-trypanosoma-cruzi-from-leukoreduced-whole-blood
#12
Teresa Jimenez-Marco, Beatriz Cancino-Faure, Enrique Girona-Llobera, M Magdalena Alcover, Cristina Riera, Roser Fisa
BACKGROUND: The parasitic Chagas disease is caused by the protozoan Trypanosoma cruzi, which is mainly transmitted by insect vectors. Other infection routes, both in endemic and in nonendemic areas, include organ and marrow transplantation, congenital transmission, and blood transfusion. Asymptomatic chronic chagasic individuals may have a low and transient parasitemia in peripheral blood and, consequently, they can unknowingly transmit the disease via blood transfusion. Riboflavin and ultraviolet (UV) light pathogen reduction is a method to reduce pathogen transfusion transmission risk based on damage to the pathogen nucleic acids...
June 2017: Transfusion
https://www.readbyqxmd.com/read/28411096/-seroprevalence-and-vertical-transmission-of-chagas-disease-in-a-cohort-of-latin-american-pregnant-women-in-a-tertiary-hospital-in-madrid
#13
Laura Francisco-González, Teresa Gastañaga-Holguera, Beatriz Jiménez Montero, Zarife Daoud Pérez, Marta Illán Ramos, Paloma Merino Amador, Miguel Ángel Herráiz Martínez, José Tomás Ramos Amador
BACKGROUND: Chagas disease, caused by Trypanosoma cruzi (T. cruzi), is endemic in Latin-America and is emerging in Spain due to immigration. The vertical transmission rate is around 5%. A routine prenatal screening with serology of all pregnant women from endemic areas is recommended to identify infected newborns, allowing early treatment and cure. OBJECTIVE: The aim of this study was to estimate the prevalence of positive Chagas serology in a cohort of pregnant women from Latin-America and its vertical transmission...
April 12, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28369287/toward-improving-early-diagnosis-of-congenital-chagas-disease-in-an-endemic-setting
#14
Louisa A Messenger, Robert H Gilman, Manuela Verastegui, Gerson Galdos-Cardenas, Gerardo Sanchez, Edward Valencia, Leny Sanchez, Edith Malaga, Victoria R Rendell, Malasa Jois, Vishal Shah, Nicole Santos, Maria Del Carmen Abastoflor, Carlos LaFuente, Rony Colanzi, Ricardo Bozo, Caryn Bern
Background: Congenital Trypanosoma cruzi transmission is now estimated to account for 22% of new infections, representing a significant public health problem across Latin America and internationally. Treatment during infancy is highly efficacious and well tolerated, but current assays for early detection fail to detect >50% of infected neonates, and 9-month follow-up is low. Methods: Women who presented for delivery at 2 urban hospitals in Santa Cruz Department, Bolivia, were screened by rapid test...
July 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28325368/chagas-disease-diagnostic-applications-present-knowledge-and-future-steps
#15
REVIEW
V Balouz, F Agüero, C A Buscaglia
Chagas disease, caused by the protozoan Trypanosoma cruzi, is a lifelong and debilitating illness of major significance throughout Latin America and an emergent threat to global public health. Being a neglected disease, the vast majority of Chagasic patients have limited access to proper diagnosis and treatment, and there is only a marginal investment into R&D for drug and vaccine development. In this context, identification of novel biomarkers able to transcend the current limits of diagnostic methods surfaces as a main priority in Chagas disease applied research...
2017: Advances in Parasitology
https://www.readbyqxmd.com/read/28319561/pediatric-enteric-neuropathies-diagnosis-and-current-management
#16
Maggie L Westfal, Allan M Goldstein
PURPOSE OF REVIEW: Neurointestinal diseases are increasingly recognized as causes of significant gastrointestinal morbidity in children. This review highlights the most common pediatric enteric neuropathies and their diagnosis and management, emphasizing insights and discoveries from the most recent literature available. RECENT FINDINGS: The embryologic and histopathologic causes of enteric neuropathies are varied. They range from congenital aganglionosis in Hirschsprung disease, to autoimmune-mediated loss of neuronal subtypes in esophageal achalasia and Chagas disease, to degenerative neuropathies in some cases of chronic intestinal pseudo-obstruction and gastroparesis...
June 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28202792/towards-a-new-strategy-for-diagnosis-of-congenital-trypanosoma-cruzi-infection
#17
Alba Abras, Carmen Muñoz, Cristina Ballart, Pere Berenguer, Teresa Llovet, Mercedes Herrero, Silvia Tebar, María-Jesús Pinazo, Elizabeth Posada, Carmen Martí, Victoria Fumadó, Jordi Bosch, Oriol Coll, Teresa Juncosa, Gemma Ginovart, Josep Armengol, Joaquim Gascón, Montserrat Portús, Montserrat Gállego
The immigration of Latin American women of childbearing age has spread the congenital transmission of Chagas disease to areas of nonendemicity, and the disease is now a worldwide problem. Some European health authorities have implemented screening programs to prevent vertical transmission, but the lack of a uniform protocol calls for the urgent establishment of a new strategy common to all laboratories. Our aims were to (i) analyze the trend of passive IgG antibodies in the newborn by means of five serological tests for the diagnosis and follow-up of congenital Trypanosoma cruzi infection, (ii) assess the utility of these techniques for diagnosing a congenital transmission, and (iii) propose a strategy for a prompt, efficient, and cost-effective diagnosis of T...
May 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28095511/epidemiology-and-molecular-typing-of-trypanosoma-cruzi-in-naturally-infected-hound-dogs-and-associated-triatomine-vectors-in-texas-usa
#18
Rachel Curtis-Robles, Karen F Snowden, Brandon Dominguez, Lewis Dinges, Sandy Rodgers, Glennon Mays, Sarah A Hamer
BACKGROUND: Trypanosoma cruzi is the etiologic agent of Chagas disease throughout the Americas. Few population-level studies have examined the epidemiology of canine infection and strain types of T. cruzi that infect canines in the USA. We conducted a cross-sectional study of T. cruzi infection in working hound dogs in south central Texas, including analysis of triatomine vectors collected within kennel environments. METHODOLOGY/PRINCIPLE FINDINGS: Paired IFA and Chagas Stat-Pak serological testing showed an overall seroprevalence of 57...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28076583/-social-factors-associated-with-use-of-prenatal-care-in-ecuador
#19
Amaya Sánchez-Gómez, William Cevallos, Mario J Grijalva, Luis C Silva-Ayçaguer, Susana Tamayo, Jerry O Jacobson, Jaime A Costales, Rodrigo Jiménez-Garcia, Valentín Hernández-Barrera, Suzanne Serruya, Celia Riera
Objectives: Prenatal care is a pillar of public health, enabling access to interventions including prevention of mother-to-child transmission of HIV and congenital syphilis. This paper describes social factors related to use of prenatal care in Ecuador. Methods: In 2011 and 2012, participant clinical history and interview information was analyzed from a national probability sample of 5 998 women presenting for delivery or miscarriage services in 15 healthcare facilities in Ecuador, to estimate prevalence of HIV, syphilis, and Chagas disease, and prenatal care coverage...
November 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28031550/bug-smash-bug-splash-a-case-report-of-an-unusual-transmission-of-american-trypanosomiasis-with-a-brief-review-of-the-literature
#20
REVIEW
Rafael Hernán Navarrete-Sandoval, Maximiliano Servín-Rojas
BACKGROUND Chagas disease is a chronic parasitosis transmitted by the inoculation of infected triatomine feces into wounds or conjunctival sac, transfusion, congenitally, organ transplantation, and ingestion of contaminated food. The disease is classified into an acute and chronic phase; the latter is a life-long infection that can be asymptomatic or progress to cardiac or digestive complications. CASE REPORT We report a case of acute-phase Chagas disease, transmitted by the splash of gut content from an infected triatomine into the conjunctival mucosa...
December 29, 2016: American Journal of Case Reports
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