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https://www.readbyqxmd.com/read/29762675/rxr-ligands-modulate-thyroid-hormone-signaling-competence-in-young-xenopus-laevis-tadpoles
#1
Brenda J Mengeling, Michael L Goodson, J David Furlow
Appropriate thyroid hormone (TH) signaling through thyroid hormone receptors (TRs) is essential for vertebrate development. Amphibian metamorphosis is initiated and sustained through the action of TH on TRs which are conserved across vertebrates. TRs heterodimerize with retinoid-X receptors (RXRs) on thyroid hormone-response elements (TREs) in the genome, yet in most cell line and adult animal studies, RXR ligands do not affect expression of TR target genes. We used a quantitative, precocious metamorphosis assay to interrogate the effects of the RXR agonist bexarotene (Bex) and the RXR antagonist UVI 3003 (UVI) on T3-induced resorption phenotypes in Xenopus laevis tadpoles one-week post-fertilization...
May 11, 2018: Endocrinology
https://www.readbyqxmd.com/read/29660239/the-population-genetic-test-tajima-s-d-identifies-genes-encoding-pathogen-associated-molecular-patterns-and-other-virulence-related-genes-in-ralstonia-solanacearum
#2
Noam Eckshtain-Levi, Alexandra J Weisberg, Boris A Vinatzer
Detection of pathogen-associated molecular patterns (PAMPs) by plant pattern receptors (PRRs) is an essential part of plant immunity. Until recently, elf18, an epitope of elongation factor tu (EF-Tu), was the sole confirmed PAMP of Ralstonia solanacearum, the causal agent of bacterial wilt disease, limiting our understanding of R. solanacearum - plant interactions. Therefore, we set out to identify additional R. solanacearum PAMPs based on the hypothesis that genes encoding PAMPs are under selection to avoid recognition by plant PRRs...
April 16, 2018: Molecular Plant Pathology
https://www.readbyqxmd.com/read/29652929/immunogenicity-and-safety-of-three-consecutive-production-lots-of-the-non-replicating-smallpox-vaccine-mva-a-randomised-double-blind-placebo-controlled-phase-iii-trial
#3
Edgar Turner Overton, Steven J Lawrence, Eva Wagner, Katrin Nopora, Siegfried Rösch, Philip Young, Darja Schmidt, Christian Kreusel, Sonja De Carli, Thomas P Meyer, Heinz Weidenthaler, Nathaly Samy, Paul Chaplin
BACKGROUND: Modified Vaccinia Ankara (MVA) is a live, viral vaccine under advanced development as a non-replicating smallpox vaccine. A randomised, double-blind, placebo-controlled phase III clinical trial was conducted to demonstrate the humoral immunogenic equivalence of three consecutively manufactured MVA production lots, and to confirm the safety and tolerability of MVA focusing on cardiac readouts. METHODS: The trial was conducted at 34 sites in the US. Vaccinia-naïve adults aged 18-40 years were randomly allocated to one of four groups using a 1:1:1:1 randomization scheme...
2018: PloS One
https://www.readbyqxmd.com/read/29464813/the-economic-burden-of-overactive-bladder-oab-and-its-effects-on-the-costs-associated-with-other-chronic-age-related-comorbidities-in-the-united-states
#4
Emily Durden, David Walker, Stephani Gray, Robert Fowler, Paul Juneau, Katherine Gooch
AIMS: The prevalence of OAB increases with age and is associated with several chronic comorbidities. However, the impact of OAB on the healthcare costs of patients with such comorbidities is not well-understood. This study aimed to quantify the impact of OAB on healthcare costs and assess the potential moderating effects of OAB on the costs of patients with chronic comorbidities. METHODS: Adults with evidence of OAB/OAB-related therapy between 1/1/2008-12/31/2013 were identified from two large, administrative claims databases...
February 21, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29339143/gene-silencing-reveals-multiple-functions-of-na-k-atpase-in-the-salmon-louse-lepeophtheirus-salmonis
#5
Anna Z Komisarczuk, Heidi Kongshaug, Frank Nilsen
Na+ /K+ -ATPase has a key function in a variety of physiological processes including membrane excitability, osmoregulation, regulation of cell volume, and transport of nutrients. While knowledge about Na+ /K+ -ATPase function in osmoregulation in crustaceans is extensive, the role of this enzyme in other physiological and developmental processes is scarce. Here, we report characterization, transcriptional distribution and likely functions of the newly identified L. salmonis Na+ /K+ -ATPase (LsalNa+ /K+ -ATPase) α subunit in various developmental stages...
February 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29327195/long-term-variations-of-the-riverine-input-of-potentially-toxic-dissolved-elements-and-the-impacts-on-their-distribution-in-jiaozhou-bay-china
#6
Changyou Wang, Jinqiang Guo, Shengkang Liang, Yunfei Wang, Yanqun Yang, Xiulin Wang
The concentrations of the potentially toxic dissolved elements (PTEs) As, Hg, Cr, Pb, Cd, and Cu in the main rivers into Jiaozhou Bay (JZB) during 1981-2006 were measured, and the impact of the fluvial PTE fluxes on their distributions in the bay was investigated. The overall average concentration in the rivers into JZB ranged from 8.8 to 39.6 μg L-1 for As, 10.1 to 632.6 ng L-1 for Hg, 4.1 to 3003.6 μg L-1 for Cr, 8.5 to 141.9 μg L-1 for Pb, 1.1 to 34.2 μg L-1 for Cd, and 13.2 to 1042.8 μg L-1 for Cu...
March 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29311201/travelling-wave-amplitudes-as-solutions-of-the-phase-field-crystal-equation
#7
I G Nizovtseva, P K Galenko
The dynamics of the diffuse interface between liquid and solid states is analysed. The diffuse interface is considered as an envelope of atomic density amplitudes as predicted by the phase-field crystal model (Elder et al. 2004 Phys. Rev. E 70 , 051605 (doi:10.1103/PhysRevE.70.051605); Elder et al. 2007 Phys. Rev. B 75 , 064107 (doi:10.1103/PhysRevB.75.064107)). The propagation of crystalline amplitudes into metastable liquid is described by the hyperbolic equation of an extended Allen-Cahn type (Galenko & Jou 2005 Phys...
February 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29258377/clinical-features-of-kidney-transplant-recipients-admitted-to-the-intensive-care-unit
#8
Flávio Geraldo Rezende Freitas, Fábio Lombardi, Eduardo Souza Pacheco, Tainá Veras de Sandes-Freitas, Laila Almeida Viana, Hélio Tedesco-Silva Junior, José Osmar Medina-Pestana, Antônio Tonete Bafi, Flavia Ribeiro Machado
INTRODUCTION: There is a paucity of data regarding the complications in kidney transplant patients who may require intensive care unit (ICU) management, despite being the most common solid organ transplant worldwide. OBJECTIVE: To identify the main reasons for ICU admission and to determine the factors associated with hospital mortality in kidney transplant recipients. DESIGN: This single-center retrospective cohort study was conducted between September 2013 and June 2014, including all consecutive kidney transplant patients requiring ICU admission...
March 2018: Progress in Transplantation
https://www.readbyqxmd.com/read/29090382/determinants-of-calcium-and-oxalate-excretion-in-subjects-with-calcium-nephrolithiasis-the-role-of-metabolic-syndrome-traits
#9
Andrea Ticinesi, Angela Guerra, Franca Allegri, Antonio Nouvenne, Gianfranco Cervellin, Marcello Maggio, Fulvio Lauretani, Loris Borghi, Tiziana Meschi
BACKGROUND: The association of metabolic syndrome (MetS) traits with urinary calcium (UCE) or oxalate excretion (UOE) is uncertain in calcium stone formers (CSFs). Our aim was to investigate this association in a large group of Caucasian CSFs. METHODS: We retrospectively reviewed data of CSFs evaluated at our Kidney Stone Clinic from 1984 to 2015. Data on body mass index (BMI), MetS traits defined according to international consensus, family history of urolithiasis, anti-hypertensive treatments, calcemia, renal function, and 24-h urinary profile of lithogenic risk were collected...
October 31, 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/29022159/modulation-of-trace-element-bioavailability-for-two-earthworm-species-after-biochar-amendment-into-a-contaminated-technosol
#10
Lilian Marchand, Sophie Brunel-Muguet, Isabelle Lamy, Michel Mench, Celine Pelosi
Biochars are used as amendments to improve soil quality, but their effects on edaphic organisms such as earthworms remain controversial. This study aimed to assess the effects of adding a poultry manure-derived biochar into a contaminated technosol on trace element (TE) (i.e. As, Cd, Cu, Pb, and Zn) bioavailability for two earthworm species, Aporrectodea icterica and Aporrectodea longa. Three components of the bioavailability concept were determined using a pot experiment: (1) total soil TE (potentially reactive) and TE concentrations in the soil pore water (environmental availability), (2) TE concentrations in depurated whole earthworm bodies (environmental bioavailability) and (3) ecophysiological and biochemical effects on earthworms (toxicological bioavailability)...
December 2017: Ecotoxicology
https://www.readbyqxmd.com/read/29017757/effects-of-retinoic-acid-signaling-on-extraocular-muscle-myogenic-precursor-cells-in-vitro
#11
Sadie L Hebert, Krysta R Fitzpatrick, Samantha A McConnell, Anja Cucak, Ching Yuan, Linda K McLoon
One major difference between limb and extraocular muscles (EOM) is the presence of an enriched population of Pitx2-positive myogenic precursor cells in EOM compared to limb muscle. We hypothesize that retinoic acid regulates Pitx2 expression in EOM myogenic precursor cells and that its effects would differ in leg muscle. The two muscle groups expressed differential retinoic acid receptor (RAR) and retinoid X receptor (RXR) levels. RXR co-localized with the Pitx2-positive cells but not with those expressing Pax7...
December 1, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28937695/trinuclear-complexes-of-palladium-ii-with-chalcogenated-n-heterocyclic-carbenes-catalysis-of-selective-nitrile-primary-amide-interconversion-and-sonogashira-coupling
#12
Pooja Dubey, Sonu Gupta, Ajai K Singh
3-Methyl-1-(2-(phenylthio/seleno)ethyl)-1H-benzo[d]imidazol-3-ium iodide (L1/L2), a precursor of sulfated/selenated N-heterocyclic carbene, was synthesized by the reaction of benzimidazole with 1,2-dichloroethane followed by treatment with PhS/SeNa and MeI. The reaction of L1/L2 with Ag2 O followed by treatment with [Pd(CH3 CN)2 Cl2 ] (metal to ligand ratio 3 : 2), i.e. transmetallation, resulted in trinuclear palladium(ii) complexes [Pd3 (L1/L2-HI)2 (CH3 CN)Cl6 ] (1-2). The complexes were characterized with1 H,13 C{1 H} and77 Se{1 H} NMR (2 only), elemental analyses, HR-MS and single-crystal X-ray diffraction...
October 3, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28691036/detection-of-secondary-causes-and-coexisting-diseases-in-hypertensive-patients-osa-and-pa-are-the-common-causes-associated-with-hypertension
#13
Lei Wang, Nanfang Li, Xiaoguang Yao, Guijuan Chang, Delian Zhang, Mulalibieke Heizhati, Menghui Wang, Qin Luo, Jianqiong Kong
BACKGROUND: Since the control rate of blood pressure is lower in mainland China, the aim of this study is to investigate the proportion of secondary causes and coexisting diseases of hypertension in hypertensive patients. METHODS: Data on consecutive patients with hypertension who visited the Hypertension Center. Diseases were detected using an established strict screening protocol. RESULTS: Detection rate of secondary causes and coexisting diseases of hypertension was 39...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28649951/video-motion-analysis-in-live-coronary-angiography-differentiates-levels-of-experience-and-provides-a-novel-method-of-skill-assessment
#14
Alexander E Rolls, Celia V Riga, Sybghat Rahim, Danail V Stoyanov, Isabelle Van Herzeele, Ghada Mikhail, Mohamad Hamady, Nicholas J Cheshire, Colin D Bicknell
AIMS: Video motion analysis (VMA) uses fluoroscopic sequences to derive catheter and guidewire movement, and is able to calculate 2D catheter-tip path length (PL) on the basis of frame-by-frame pixel coordinates. The objective of this study was to validate VMA in coronary angiography as a method of skill assessment. METHODS AND RESULTS: Forty-seven coronary interventions performed by 10 low- (<1,000 cases; group A), five medium- (1,000-4,000; group B) and six high- (>4,000; group C) experience-volume cardiologists were prospectively recorded and analysed using VMA software...
December 8, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28634056/new-and-accurate-predictive-model-for-the-efficacy-of-extracorporeal-shock-wave-therapy-in-managing-patients-with-chronic-plantar-fasciitis
#15
RANDOMIZED CONTROLLED TRIAL
Mengchen Yin, Ni Chen, Quan Huang, Anastasia Sulindro Marla, Junming Ma, Jie Ye, Wen Mo
OBJECTIVE: To identify factors for the outcome of a minimum clinically successful therapy and to establish a predictive model of extracorporeal shock wave therapy (ESWT) in managing patients with chronic plantar fasciitis. DESIGN: Randomized, controlled, prospective study. SETTING: Outpatient of local medical center settings. PARTICIPANTS: Patients treated for symptomatic chronic plantar fasciitis between 2014 and 2016 (N=278)...
December 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28584004/vaginal-birth-after-two-previous-caesarean-deliveries-in-a-patient-with-uterus-didelphys-and-an-interuterine-septal-defect
#16
Njoki Ng'ang'a, Jonathan Ratzersdorfer, Yaakov Abdelhak
Uterus didelphys is a congenital abnormality characterised by double uteri, double cervices and a double or single vagina that affects 0.3% to 11% of the general female population. A 23-year-old woman, gravida 3 para 3003, with uterus didelphys, acquired an iatrogenic interuterine septal defect during an otherwise routine primary caesarean delivery for fetal malpresentation. The defect was repaired but noted to have dehisced during her second pregnancy. A repeat caesarean section was performed due to fetal malpresentation after an unsuccessful external cephalic version...
June 5, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28489307/non-alcoholic-fatty-liver-and-advanced-fibrosis-in-the-elderly-results-from-a-community-based-polish-survey
#17
Marek Hartleb, Kamil Barański, Jan Zejda, Jerzy Chudek, Andrzej Więcek
BACKGROUND & AIMS: Development of non-alcoholic fatty liver (NAFL) is dependent on metabolic factors occurring at an increased frequency with advancing age. Until now, few studies have explored the prevalence of NAFL in aged populations. Our study aimed to determine the prevalence of NAFL and advanced fibrosis in the elderly population participating in a national survey of a community-based elderly cohort. METHODS: A total of 3003 participants (mean age 79.6 years, 46...
November 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28426386/new-zealanders-working-non-standard-hours-also-have-greater-exposure-to-other-workplace-hazards
#18
Sarah M Jay, Philippa H Gander, Amanda Eng, Soo Cheng, Jeroen Douwes, Lis Ellison-Loschmann, Dave McLean, Neil Pearce, Andrea 'tMannetje
Exposure to workplace hazards, such as dust, solvents, and fumes, has the potential to adversely affect the health of people. However, the effects of workplace hazards on health may differ when exposure occurs at different times in the circadian cycle, and among people who work longer hours or who do not obtain adequate sleep. The aim of the present study was to document exposures to workplace hazards across a national sample of New Zealanders, comparing people who work a standard 08:00 -17:00 h Monday-to-Friday working week (Std hours) and those who do not (N-Std hours)...
2017: Chronobiology International
https://www.readbyqxmd.com/read/28403475/cigarette-smoking-during-pregnancy-do-complete-abstinence-and-low-level-cigarette-smoking-have-similar-impact-on-birth-weight
#19
Ivan Berlin, Jean-Louis Golmard, Nelly Jacob, Marie-Laure Tanguy, Stephen J Heishman
Objectives: Despite awareness of negative health outcomes associated with smoking, pregnant smokers might reduce their tobacco consumption thinking that a low smoking rate reduces smoking-related negative birth outcomes. We aimed to assess in a clinical sample whether there is a smoking rate that would not impact on birth weight (BW). Methods: Pregnant smokers ≥18 years, gestational age of 9-20 weeks of amenorrhea, motivated to quit smoking, smoking ≥5 cigarettes/day (cpd) and their newborns (381 singleton, live births) were included in this secondary analysis of a French smoking cessation trial...
May 1, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28390604/protective-role-of-misoprostol-in-prevention-of-gentamicin-ototoxicity
#20
Murat Dogan, Halil Polat, Mehmet Yasar, Ali Bayram, Duran Karatas, İbrahim Hira, Ahmet Kale, Fatma Senel, İbrahim Özcan
OBJECTIVES: To demonstrate potential protective effect of misoprostol on cochlear toxicity caused by gentamicin with electrophysiological tests and histopathological studies. MATERIALS AND METHODS: The study included 80 ears of 40 rats with normal hearing threshold and DPOAE value in both ears. Animals were assigned into 4 groups. The rats were randomized into 4 groups. Group I (n = 10): Gentamicin, Group II (n = 10): Gentamicin plus misoprostol, Group III (n = 10): Saline; Group IV (n = 10): Misoprostol...
May 2017: International Journal of Pediatric Otorhinolaryngology
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