keyword
https://read.qxmd.com/read/38541026/a-cross-sectional-study-on-the-role-of-a-lab-test-screening-program-in-defining-cardiovascular-disease-risk-prevalence
#21
JOURNAL ARTICLE
Antoanela Curici, Mihaela Roxana Popescu, Viviana Adriana Pîrvuleț, Gabriela-Irina Marinescu, Ana Corina Ionescu
Recent epidemiologic studies carried out in Romania confirmed an ascending trend for cardiovascular disease (CVD) risk factor prevalence such as diabetes mellitus (DM), obesity and dyslipidemia. The aim of this study is to describe the CVD risk factor profile and preventative behavior in a representative sample of the general adult population of an Eastern Romanian urban area. More than 70% of the studied population had a body mass index (BMI) above the normal range for their age, with 36.7% of the subjects residing in obesity and severe obesity clusters...
March 4, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38539988/progesterone-related-diabetes-mellitus-in-the-bitch-current-knowledge-the-role-of-pyometra-and-relevance-in-practice
#22
REVIEW
Álan Gomes Pöppl, José Lucas Xavier Lopes, Taís Bock Nogueira, Denise Iparraguirre da Silva, Bruna Dos Santos Machado
Progesterone-related diabetes mellitus (PRDM) in dogs is known for its particular potential for diabetes remission. This narrative review aims to provide relevant detailed information on (1) the canine estrus cycle and its impact on canine diabetes mellitus (CDM) etiology and management, (2) the role of pyometra as a further cause of insulin resistance, and (3) useful individual therapeutic and preventive strategies. PRDM is recognized due to diestrus, exogenous progestogen exposure, pregnancy, and P4-production ovarian dysfunction...
March 14, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38539811/genetic-and-transcriptomic-background-of-oxidative-stress-and-antioxidative-therapies-in-late-complications-of-type-2-diabetes-mellitus-a-systematic-review
#23
REVIEW
Gašper Tonin, Vita Dolžan, Jasna Klen
This systematic review extensively investigated the role of the genetic and transcriptomic factors in late complications of type 2 diabetes mellitus (T2DM) and the current approaches targeting oxidative-stress-related pathways with antioxidant therapies. To cover our broad research area, we have conducted two systematic searches, the first focusing on genetic and transcriptomic factors affecting oxidative stress and the second one focusing on the antioxidant therapies in late complications of T2DM. The final review included 33 genetic and transcriptomic studies and 23 interventional randomized clinical trials...
February 24, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38536196/offloading-and-adherence-through-technological-advancements-modern-approaches-for-better-foot-care-in-diabetes
#24
REVIEW
Sicco A Bus, Neil D Reeves, David G Armstrong, Bijan Najafi
OBJECTIVE: This manuscript aims to provide a review and synthesis of contemporary advancements in footwear, sensor technology for remote monitoring, and digital health, with a focus on improving offloading and measuring and enhancing adherence to offloading in diabetic foot care. METHODS: A narrative literature review was conducted by sourcing peer-reviewed articles, clinical studies, and technological innovations. This paper includes a review of various strategies, from specifically designed footwear, smart insoles and boots to using digital health interventions, which aim to offload plantar pressure and help prevent and manage wounds more effectively by improving the adherence to such offloading...
February 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38535079/skin-lesions-with-loss-of-tissue-and-cutaneous-onset-sepsis-the-skin-infection-sepsis-relationship
#25
JOURNAL ARTICLE
Adriana-Ionela Pătrașcu, Dan Vâță, Doinița Temelie-Olinici, Mădălina Mocanu, Dumitrița-Lenuța Guguluș, Mădălina Marinescu, Liviu Stafie, Bogdan-Marian Tarcău, Ioana Creţu, Ioana-Adriana Popescu, Carmen-Diana Cimpoeșu, Laura Gheucă-Solovăstru
Infectious and inflammatory dermatoses featuring skin lesions with loss of tissue expose skin layers to microbial invasions, disrupt the normal skin microbiome, and potentially lead to sepsis. However, literature data on the incidence of cutaneous-onset sepsis are scarce. This retrospective observational study assessed hospital admissions for primary skin lesions without bacterial infections and sepsis during 2020-2022 in the largest emergency hospital in NE Romania. Of 509 patients, 441 had infected lesions, 78 had sepsis caused by venous ulcers from microbial eczema cellulitis, superinfected bullous dermatoses, erysipelas, and erythroderma...
March 21, 2024: Diagnostics
https://read.qxmd.com/read/38534428/probiotics-supplementation-during-pregnancy-can-they-exert-potential-beneficial-effects-against-adverse-pregnancy-outcomes-beyond-gestational-diabetes-mellitus
#26
JOURNAL ARTICLE
Efthymios Poulios, Eleni Pavlidou, Sousana K Papadopoulou, Kalliopi Rempetsioti, Athanasios Migdanis, Maria Mentzelou, Maria Chatzidimitriou, Ioannis Migdanis, Odysseas Androutsos, Constantinos Giaginis
BACKGROUND: Probiotics, as supplements or food ingredients, are considered to exert promising healthy effects when administered in adequate quantity. Probiotics' healthy effects are related with the prevention of many diseases, as well as decreasing symptom severity. Currently, the most available data concerning their potential health effects are associated with metabolic disorders, including gestational diabetes mellitus. There is also clinical evidence supporting that they may exert beneficial effects against diverse adverse pregnancy outcomes...
February 28, 2024: Biology
https://read.qxmd.com/read/38532435/liver-stiffness-and-associated-risk-factors-among-people-with-a-history-of-injecting-drugs-a-prospective-cohort-study
#27
JOURNAL ARTICLE
Karl Trygve Druckrey-Fiskaaen, Jørn Henrik Vold, Tesfaye Madebo, Håvard Midgard, Olav Dalgard, Rafael Alexander Leiva, Lars T Fadnes
BACKGROUND: Persons with opioid use disorders (OUD) and persons with substance use disorders (SUD) who inject substances have a reduced life expectancy of up to 25 years compared with the general population. Chronic liver diseases are a substantial cause of this. Screening strategies based on liver stiffness measurements (LSM) may facilitate early detection, timely intervention, and treatment of liver disease. This study aims to investigate the extent of chronic liver disease measured with transient elastography and the association between LSM and various risk factors, including substance use patterns, hepatitis C virus (HCV) infection, alcohol use, body mass index, age, type 2 diabetes mellitus, and high-density lipoprotein (HDL) cholesterol among people with OUD or with SUD who inject substances...
March 26, 2024: Substance Abuse Treatment, Prevention, and Policy
https://read.qxmd.com/read/38532282/glucocorticoid-induced-hyperglycemia-a-neglected-problem
#28
JOURNAL ARTICLE
Jung-Hwan Cho, Sunghwan Suh
Glucocorticoids provide a potent therapeutic response and are widely used to treat a variety of diseases, including coronavirus disease 2019 (COVID-19) infection. However, the issue of glucocorticoid-induced hyperglycemia (GIH), which is observed in over one-third of patients treated with glucocorticoids, is often neglected. To improve the clinical course and prognosis of diseases that necessitate glucocorticoid therapy, proper management of GIH is essential. The key pathophysiology of GIH includes systemic insulin resistance, which exacerbates hepatic steatosis and visceral obesity, as well as proteolysis and lipolysis of muscle and adipose tissue, coupled with β-cell dysfunction...
March 27, 2024: Endocrinology and Metabolism
https://read.qxmd.com/read/38532020/contemporary-pharmacological-treatment-and-management-of-heart-failure
#29
REVIEW
Biykem Bozkurt
The prevention and treatment strategies for heart failure (HF) have evolved in the past two decades. The stages of HF have been redefined, with recognition of the pre-HF state, which encompasses asymptomatic patients who have developed either structural or functional cardiac abnormalities or have elevated plasma levels of natriuretic peptides or cardiac troponin. The first-line treatment of patients with HF with reduced ejection fraction includes foundational therapies with angiotensin receptor-neprilysin inhibitors, angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, β-blockers, mineralocorticoid receptor antagonists, sodium-glucose cotransporter 2 (SGLT2) inhibitors and diuretics...
March 26, 2024: Nature Reviews. Cardiology
https://read.qxmd.com/read/38531534/comprehensive-assessment-of-risk-factors-and-pathogenic-characteristics-of-wound-infections-following-thoracoscopic-radical-resection-for-lung-cancer
#30
JOURNAL ARTICLE
Jian Xu, Jianhua Zhu
Lung cancer remains a leading cause of cancer-related mortality, with surgical resection as a primary treatment modality. However, postoperative wound infections (PWIs) pose significant risks following thoracoscopic radical resection. This study aims to identify the risk factors and pathogenetic characteristics associated with PWIs in lung cancer surgery. A comprehensive retrospective study was conducted from August 2021 to June 2023 at our institution. The study included 30 patients who developed PWIs and 60 controls who did not, following thoracoscopic radical resection for lung cancer...
April 2024: International Wound Journal
https://read.qxmd.com/read/38531488/the-dysregulated-autophagy-in-osteoarthritis-revisiting-molecular-profile
#31
JOURNAL ARTICLE
Liang Liu, Jie Wang, Lu Liu, Wenling Shi, Huajie Gao, Lun Liu
The risk factors of osteoarthritis (OA) are different and obesity, lifestyle, inflammation, cell death mechanisms and diabetes mellitus are among them. The changes in the biological mechanisms are considered as main regulators of OA pathogenesis. The dysregulation of autophagy is observed in different human diseases. During the pathogenesis of OA, the autophagy levels (induction or inhibition) change. The supportive and pro-survival function of autophagy can retard the progression of OA. The protective autophagy prevents the cartilage degeneration...
March 24, 2024: Progress in Biophysics and Molecular Biology
https://read.qxmd.com/read/38530908/adiponectin-reduces-glomerular-endothelial-glycocalyx-disruption-and-restores-glomerular-barrier-function-in-a-mouse-model-of-type-2-diabetes
#32
JOURNAL ARTICLE
Sarah Fawaz, Aldara Martin Alonso, Yan Qiu, Raina Ramnath, Holly Stowell-Connolly, Monica Gamez, Carl May, Colin Down, Richard J Coward, Matthew J Butler, Gavin I Welsh, Simon C Satchell, Rebecca R Foster
Adiponectin has vascular anti-inflammatory and protective effects. Whilst adiponectin is known to protect against the development of albuminuria, historically the focus has been on podocyte protection within the glomerular filtration barrier (GFB). The first barrier to albumin in the GFB is the endothelial glycocalyx (eGlx), a surface gel-like barrier covering glomerular endothelial cells (GEnC). In diabetes, eGlx dysfunction occurs before podocyte damage, hence we hypothesized that adiponectin could protect from eGlx damage to prevent early vascular damage in diabetic kidney disease (DKD)...
March 26, 2024: Diabetes
https://read.qxmd.com/read/38529400/causal-relationship-between-genetically-predicted-type-2-diabetes-mellitus-and-male-infertility
#33
JOURNAL ARTICLE
Cuihua Fan, Jiandong Zhang, Dongbiao Qiu
BACKGROUND: Diabetes mellitus (DM) stands as the most prevalent endocrine abnormality affecting the physiological systems and organs and impairing the male reproductive functions. Type 2 Diabetes Mellitus (T2DM), accounting for about 90-95% of DM, is closely associated with male infertility. However, the magnitude of the causal relationships between T2DM and male infertility remains unclear. The current investigation was to explore the causal relationship between T2DM and male infertility utilizing the Mendelian Randomization (MR) analysis...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38529167/new-insights-into-the-effects-of-sars-cov-2-on-metabolic-organs-a-narrative-review-of-covid-19-induced-diabetes
#34
REVIEW
Lu Li, Lin Li, Xianhui Cai, Zongfu Pan
Coronavirus disease 2019 (COVID-19)-induced new-onset diabetes has raised widespread concerns. Increased glucose concentration and insulin resistance levels were observed in the COVID-19 patients. COVID-19 patients with newly diagnosed diabetes may have worse clinical outcomes and can have serious consequences. The types and exact mechanisms of COVID-19-caused diabetes are not well understood. Understanding the direct effects of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on pancreatic beta cells and insulin target metabolism organs, such as the liver, muscle, and adipose tissues, will provide new ideas for preventing and treating the new-onset diabetes induced by COVID-19...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38528847/hyperbaric-oxygen-therapy-for-diabetic-foot-ulcers-based-on-wagner-grading-a-systematic-review-and-meta-analysis
#35
JOURNAL ARTICLE
Mendy Hatibie Oley, Maximillian Christian Oley, Billy Johnson Kepel, Muhammad Faruk, Angelica Maurene Joicetine Wagiu, Irawan Sukarno, Marcella Tirsa Tulong, Vania Sukarno
BACKGROUND: Diabetic foot ulcers (DFUs) are common complications of uncontrolled diabetes mellitus that can result in infection and amputation of the lower extremities. This study compared the benefits and risks of hyperbaric oxygen therapy with those of other DFU treatments, based on the Wagner grading system. METHODS: Systematic searches for randomly controlled trials using hyperbaric oxygen therapy for DFUs were performed using PubMed, the Cochrane Library, and Embase...
March 2024: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/38528822/maladaptive-response-following-glucose-overload-in-glut4-overexpressing-h9c2-cardiomyoblasts
#36
JOURNAL ARTICLE
Bernd Stratmann, Britta Eggers, Yvonne Mattern, Tayana Silva de Carvalho, Katrin Marcus-Alic, Diethelm Tschoepe
BACKGROUND: Glucose overload drives diabetic cardiomyopathy by affecting the tricarboxylic acid pathway. However, it is still unknown how cells could overcome massive chronic glucose influx on cellular and structural level. METHODS/MATERIALS: Expression profiles of hyperglycemic, glucose transporter-4 (GLUT4) overexpressing H9C2 (KE2) cardiomyoblasts loaded with 30 mM glucose (KE230L) and wild type (WT) cardiomyoblasts loaded with 30 mM glucose (WT30L) were compared using proteomics, real-time polymerase quantitative chain reaction analysis, or Western blotting, and immunocytochemistry...
March 26, 2024: Diabetes, Obesity & Metabolism
https://read.qxmd.com/read/38528508/triglyceride-glucose-index-in-early-pregnancy-predicts-the-risk-of-gestational-diabetes-a-prospective-cohort-study
#37
JOURNAL ARTICLE
Yufeng Guo, Junwen Lu, Mailiman Bahani, Guifeng Ding, Lei Wang, Yuxia Zhang, Huanmei Zhang, Chengyao Liu, Lijun Zhou, Xiaolan Liu, Fangshen Li, Xiaoli Wang, Hong Ding
OBJECTIVE: This study aimed to investigate the association between the triglyceride-glucose (TyG) index in early pregnancy and the development of gestational diabetes mellitus (GDM) in the second trimester. The primary objectives were to evaluate the predictive potential of the TyG index for GDM, determine the optimal threshold value of the TyG index for GDM assessment, and compare the predictive performance of the TyG index alone versus its combination with maternal age and pre-pregnancy body mass index on GDM...
March 25, 2024: Lipids in Health and Disease
https://read.qxmd.com/read/38528482/effect-of-multidisciplinary-care-on-diabetic-kidney-disease-a-retrospective-cohort-study
#38
JOURNAL ARTICLE
Ayano Hayashi, Kayoko Mizuno, Kanna Shinkawa, Kazunori Sakoda, Satomi Yoshida, Masato Takeuchi, Motoko Yanagita, Koji Kawakami
BACKGROUND: Diabetic kidney disease (DKD) is the most common disease among patients requiring dialysis for the first time in Japan. Multidisciplinary care (MDC) may prevent the progression of kidney failure. However, the effectiveness and timing of MDC to preserve kidney function in patients with DKD is unclear. Therefore, the aim of this study was to investigate whether MDC for patients with DKD affects the preservation of kidney function as well as the timing of MDC in clinical practice...
March 25, 2024: BMC Nephrology
https://read.qxmd.com/read/38528048/visit-to-visit-transition-in-txnip-gene-methylation-and-the-risk-of-type-2-diabetes-mellitus-a-nested-case-control-study
#39
JOURNAL ARTICLE
Yuying Wu, Weiling Chen, Yang Zhao, Minqi Gu, Yajuan Gao, Yamin Ke, Longkang Wang, Mengmeng Wang, Wenkai Zhang, Yaobing Chen, Weifeng Huo, Xueru Fu, Xi Li, Dongdong Zhang, Pei Qin, Fulan Hu, Yu Liu, Xizhuo Sun, Ming Zhang, Dongsheng Hu
Our study aimed to investigate the association between the transition of the TXNIP gene methylation level and the risk of incident type 2 diabetes mellitus (T2DM). This study included 263 incident cases of T2DM and 263 matched non-T2DM participants. According to the methylation levels of five loci (CpG1-5; chr1:145441102-145442001) on the TXNIP gene, the participants were classified into four transition groups: maintained low, low to high, high to low, and maintained high methylation levels. Compared with individuals whose methylation level of CpG2-5 at the TXNIP gene was maintained low, individuals with maintained high methylation levels showed a 61-87% reduction in T2DM risk (66% for CpG2 [OR: 0...
March 25, 2024: Journal of Human Genetics
https://read.qxmd.com/read/38526862/effect-of-regular-physical-activity-and-lifestyle-changes-on-insulin-resistance-in-patients-after-kidney-transplantation
#40
JOURNAL ARTICLE
Karol Granak, Matej Vnucak Monika Beliancinova, Ivana Dedinska
Insulin resistance (IR) is the most significant risk factor for post-transplant diabetes mellitus (PTDM). This study aimed to determine the effects of regular physical activity on IR and PTDM in patients after kidney transplantation (KT). The study group (n = 22) participated in aerobic or combined sports (aerobic and anaerobic). Monitoring was provided by a sports tracker (Xiaomi Mi Band 4, compatible with the Mi Fit mobile application). Waist circumference was significantly lower (p = 0.0437, p = 0...
2024: Bratislavské Lekárske Listy
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