Yuying Wu, Weiling Chen, Yang Zhao, Minqi Gu, Yajuan Gao, Yamin Ke, Longkang Wang, Mengmeng Wang, Wenkai Zhang, Yaobing Chen, Weifeng Huo, Xueru Fu, Xi Li, Dongdong Zhang, Pei Qin, Fulan Hu, Yu Liu, Xizhuo Sun, Ming Zhang, Dongsheng Hu
Our study aimed to investigate the association between the transition of the TXNIP gene methylation level and the risk of incident type 2 diabetes mellitus (T2DM). This study included 263 incident cases of T2DM and 263 matched non-T2DM participants. According to the methylation levels of five loci (CpG1-5; chr1:145441102-145442001) on the TXNIP gene, the participants were classified into four transition groups: maintained low, low to high, high to low, and maintained high methylation levels. Compared with individuals whose methylation level of CpG2-5 at the TXNIP gene was maintained low, individuals with maintained high methylation levels showed a 61-87% reduction in T2DM risk (66% for CpG2 [OR: 0...
March 25, 2024: Journal of Human Genetics