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Diabetes mellitus prevention

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https://www.readbyqxmd.com/read/29675916/serum-apoa4-levels-predicted-the-progression-of-renal-impairment-in-t2dm
#1
Chao-Wen Cheng, Che-Chang Chang, Hsiu-Wen Chen, Ching-Yu Lin, Jin-Shuen Chen
BACKGROUND: Among multiple causes, diabetic nephropathy (DN) is the major underlying renal disease that leads to end-stage renal disease (ESRD), and early diagnosis can effectively prevent or delay the progression to ESRD. Therefore, the current study aimed to develop non-invasive, accurate detection markers. MATERIALS & METHODS: For this study, 62 diabetes mellitus (DM) patients, 59 DN patients, and 21 healthy controls (HCs) were recruited. All participants' serum samples were subjected to concavanalin (Con) A affinity chromatography, which utilizes glycoproteins to discover potential markers...
April 19, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29675479/associations-of-diabetic-retinopathy-with-retinal-neurodegeneration-on-the-background-of-diabetes-mellitus-overview-of-recent-medical-studies-with-an-assessment-of-the-impact-on-healthcare-systems
#2
Rafał Muc, Agnieszka Saracen, Iwona Grabska-Liberek
Diabetes Mellitus (DM) is one of the biggest healthcare and financial problems worldwide. The disease is strongly associated with microvascular and macrovascular complications, causing co-existing diseases like Diabetic Retinopathy, Diabetic Neuropathy and Diabetic Nephropathy. Annual healthcare expenditures for diabetes treatment and complications prevention cost 727 billion USD in year 2017. Diabetes Mellitus, Diabetic Retinopathy and Diabetic Retinal Neuropathy are closely related diseases - originating from incorrectly controlled glycemia, blood pressure and lipid levels in the course of increasing resistance of the body tissues to insulin...
2018: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/29674522/smoking-and-risk-of-ischemic-stroke-in-young-men
#3
Janina Markidan, John W Cole, Carolyn A Cronin, Jose G Merino, Michael S Phipps, Marcella A Wozniak, Steven J Kittner
BACKGROUND AND PURPOSE: There is a strong dose-response relationship between smoking and risk of ischemic stroke in young women, but there are few data examining this association in young men. We examined the dose-response relationship between the quantity of cigarettes smoked and the odds of developing an ischemic stroke in men under age 50 years. METHODS: The Stroke Prevention in Young Men Study is a population-based case-control study of risk factors for ischemic stroke in men ages 15 to 49 years...
April 19, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29673658/first-trimesters-pregnancy-associated-plasma-protein-a-levels-value-to-predict-gestational-diabetes-mellitus-a-systematic-review-and-meta-analysis-of-the-literature
#4
REVIEW
Zahra Hadizadeh Talasaz, Ramin Sadeghi, Fariba Askari, Salmeh Dadgar, Atiyeh Vatanchi
Detecting pregnant women at risk of diabetes in first months can help them by early intervention for delaying or preventing onset of GDM. In this study, we aimed to assess the Predictive value of first trimester Pregnancy related plasma protein-A (PAPP-A) levels for detecting Gestational diabetes Mellitus (GDM). This systematic review and meta-analysis was conducted through probing in databases. PubMed, Scopus, Medline and Google scholar citations were searched to find the published papers from 1974 to 2017...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29673349/severe-dyslipidemia-and-concomitant-risk-factors-in-the-middle-aged-lithuanian-adults-a-cross-sectional-cohort-study
#5
Sandra Kutkienė, Žaneta Petrulionienė, Aleksandras Laucevičius, Marija Petrylaitė, Diana Maskeliūnaitė, Roma Puronaitė, Milda Kovaitė, Irma Kalibaitaitė, Egidija Rinkūnienė, Vilma Dženkevičiūtė, Vytautas Kasiulevičius
BACKGROUND: Dyslipidemia is highly prevalent and is one of the major risk factors for cardiovascular disease in Lithuania. The purpose of this study was to determine the prevalence of severe dyslipidemia in Lithuanian middle aged primary prevention population and to investigate cardiovascular risk profile. METHODS: The group of 83,376 people were examined in the Lithuanian High Cardiovascular Risk primary prevention program (LitHiR), during 2009-2015 years. This study recruited middle aged men and women without overt cardiovascular disease...
April 19, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29673333/protocol-for-the-chord-project-community-health-outreach-to-reduce-diabetes-a-cluster-randomized-community-health-worker-trial-to-prevent-diabetes
#6
Nadia Islam, Thomas Gepts, Isaac Lief, Radhika Gore, Natalie Levy, Michael Tanner, Yixin Fang, Scott E Sherman, Mark D Schwartz
BACKGROUND: Type 2 diabetes mellitus (DM) affects 9.4% of US adults and children, while another 33.9% of Americans are at risk of DM. Health care institutions face many barriers to systematically delivering the preventive care needed to decrease DM incidence. Community health workers (CHWs) may, as frontline public health workers bridging clinic and community, help overcome these challenges. This paper presents the protocol for a pragmatic, cluster-randomized trial integrating CHWs into two primary care clinics to support DM prevention for at-risk patients...
April 19, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29671868/secondary-prevention-and-lifestyle-indices-after-stroke-in-a-long-term-perspective
#7
A C Jönsson, H Delavaran, H Lövkvist, M Baturova, S Iwarsson, A Ståhl, B Norrving, A Lindgren
OBJECTIVES: To describe the long-term perspective regarding prevalence of risk factors, secondary stroke prevention, and lifestyle indices after stroke. METHODS: From a population-based one-year cohort (n = 416), we performed an observational study of 145 survivors at 16 months and 10 years after stroke (age 27-97 years) regarding secondary prevention including reaching acceptable treatment goals; nutritional status with focus on underweight; and the lifestyle indices: living situation, level of dependence, and self-assessed health condition...
April 19, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29671556/dpp-4-inhibitors-and-glp-1-receptor-agonists-for-prevention-or-delay-of-type-2-diabetes-mellitus-and-associated-complications
#8
Dustin K Smith, Matthew J Wessner
No abstract text is available yet for this article.
April 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29671539/evaluation-of-suspected-dementia
#9
Nathan Falk, Ariel Cole, T Jason Meredith
Dementia is a significant and costly health condition that affects 5 million adults and is the fifth leading cause of death among Americans older than 65 years. The prevalence of dementia will likely increase in the future because the number of Americans older than 65 years is expected to double by 2060. Risk factors for dementia include age; family history of dementia; personal history of cardiovascular disease, cerebrovascular disease, diabetes mellitus, or midlife obesity; use of anticholinergic medications; apolipoprotein E4 genotype; and lower education level...
March 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29671398/identifying-diseases-related-metabolites-using-random-walk
#10
Yang Hu, Tianyi Zhao, Ningyi Zhang, Tianyi Zang, Jun Zhang, Liang Cheng
BACKGROUND: Metabolites disrupted by abnormal state of human body are deemed as the effect of diseases. In comparison with the cause of diseases like genes, these markers are easier to be captured for the prevention and diagnosis of metabolic diseases. Currently, a large number of metabolic markers of diseases need to be explored, which drive us to do this work. METHODS: The existing metabolite-disease associations were extracted from Human Metabolome Database (HMDB) using a text mining tool NCBO annotator as priori knowledge...
April 11, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29671081/type-2-diabetes-mellitus-the-metabolic-syndrome-and-its-components-in-adult-survivors-of-acute-lymphoblastic-leukemia-and-hematopoietic-stem-cell-transplantations
#11
REVIEW
Bella Bielorai, Orit Pinhas-Hamiel
PURPOSE OF REVIEW: A growing number of pediatric acute lymphoblastic leukemia (ALL) and hematopoietic stem cell transplantation (HSCT) survivors reach adulthood and face long-term health-related problems. We review risk factors and the prevalence of the metabolic syndrome (MetS), a cluster of obesity-related comorbidities, including abdominal obesity, atherogenic dyslipidemia, elevated blood pressure, impaired glucose metabolism, and type 2 diabetes in ALL and HSCT survivors. RECENT FINDINGS: Components of the MetS are already detected during the first year of ALL maintenance therapy and significantly worsen over time...
April 18, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29670899/guava-leaf-extract-diminishes-hyperglycemia-and-oxidative-stress-prevents-%C3%AE-cell-death-inhibits-inflammation-and-regulates-nf-kb-signaling-pathway-in-stz-induced-diabetic-rats
#12
Muthukumaran Jayachandran, Ramachandran Vinayagam, Ranga Rao Ambati, Baojun Xu, Stephen Sum Man Chung
Traditional Chinese medication has been utilized by Chinese medical practitioners to treat the varied symptoms of diabetes mellitus (DM). Notably, guava leaf has been used to treat diabetes in Asia. Our present study has been designed to analyze the action of guava leaf extract (GLE) at the molecular level in treating DM. A low dose of streptozotocin (STZ) was used to induce experimental diabetes in animals. Rats were treated with GLE at different concentrations (100, 200, and 400 mg/kg b.w.). The standard drug glibenclamide (GB) (600  μ g/kg b...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29667921/glycemic-control-of-type-2-diabetes-mellitus-across-stages-of-renal-impairment-information-for-primary-care-providers
#13
Lili Tong, Sharon Adler
Chronic kidney disease (CKD) is a frequent complication of type 2 diabetes mellitus (T2DM) and elevates individuals' risk for cardiovascular disease, the leading cause of morbidity and mortality in T2DM. Achieving and maintaining tight glycemic control is key to preventing development or progression of CKD; however, improving glycemic control may be limited by effects of renal impairment on the efficacy and safety of T2DM treatments, necessitating dosing adjustments and careful evaluation of contraindications...
April 18, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29665986/prevention-and-treatment-of-type-2-diabetes-a-pathophysiological-based-approach
#14
REVIEW
Dorit Samocha-Bonet, Sophie Debs, Jerry R Greenfield
Prediabetes affects approximately 40% of American adults. Randomized trials report that a proportion of individuals with prediabetes develop diabetes despite caloric restriction, physical activity, and/or when treated with metformin, the first-line medication for patients with type 2 diabetes mellitus (T2DM). Currently, there are no valid predictors of the effectiveness of these measures in determining who will and who will not progress to the T2DM state. Few studies have examined the clinical and phenotypic predictors of better and worse glycemic response to lifestyle interventions and metformin in prediabetes and diabetes...
April 14, 2018: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/29665834/inequalities-in-the-prevalence-of-diabetes-mellitus-and-its-risk-factors-in-sri-lanka-a-lower-middle-income-country
#15
Ambepitiyawaduge Pubudu De Silva, Sudirikku Hennadige Padmal De Silva, Rashan Haniffa, Isurujith Kongala Liyanage, Saroj Jayasinghe, Prasad Katulanda, Chandrika Neelakanthi Wijeratne, Sumedha Wijeratne, Lalini Chandika Rajapaksa
BACKGROUND: Explorations into quantifying the inequalities for diabetes mellitus (DM) and its risk factors are scarce in low and lower middle income countries (LICs/LMICs). The aims of this study were to assess the inequalities of DM and its risk factors in a suburban district of Sri Lanka. METHODS: A sample of 1300 participants, (aged 35-64 years) randomly selected using a stratified multi-stage cluster sampling method, were studied employing a cross sectional descriptive design...
April 17, 2018: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29663879/anti-cancer-effects-of-metformin-recent-evidences-for-its-role-in-prevention-and-treatment-of-cancer
#16
Masoumeh Kheirandish, Hamidreza Mahboobi, Maryam Yazdanparast, Warda Kamal, Mohammad A Kamal
Metformin is widely used for the management of type 2 diabetes mellitus (T2DM). Recently growing evidence has shown its anti-cancer effects. The results are mainly obtained from observational studies and thus, little information is available concerning the mechanisms of action. Adenosine monophosphate (AMP)-activated protein kinase (AMPK) plays an important role in the mechanism of action of metformin. The anti-cancer mechanisms of metformin include direct and indirect effects. The direct effects of metformin include AMPK-independent and AMPK-dependent effects, whereas the decrease in glucose level, hyperinsulinemia, and Insulin-like growth factor 1 (IGF-1) level was considered its indirect effects...
April 16, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29663489/high-glucose-induced-excessive-reactive-oxygen-species-promote-apoptosis-through-mitochondrial-damage-in-rat-cartilage-endplate-cells
#17
Zengxin Jiang, Wei Lu, Qingmin Zeng, Defang Li, Lei Ding, Jingping Wu
PURPOSE: Diabetes mellitus (DM) is an important factor in intervertebral disc degeneration (IDD). Apoptosis of cartilage endplate (CEP) cells is one of the initiators of IDD. However, the effects of high glucose on CEP cells are still unknown. Therefore, we conducted the present study to evaluate the effects of high glucose on CEP cells and to identify the mechanisms of those effects. METHODS: Rat CEP cells were isolated and cultured in 10% foetal bovine serum (FBS, normal control) or high-glucose medium (10% FBS + 0...
April 16, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29662887/characteristics-of-heat-illness-during-hajj-a-cross-sectional-study
#18
Doaa A Abdelmoety, Nahid K El-Bakri, Wedian O Almowalld, Zyad A Turkistani, Bassam H Bugis, Eshraq A Baseif, Mohamed H Melbari, Khaled AlHarbi, Amani Abu-Shaheen
Introduction: Data regarding the characteristics and outcomes of heat illness are lacking in the literature. The present study aimed to identify the clinical characteristics, morbidity, management, and mortality associated with heat illness among Hajj participants. Methods: A cross-sectional study was conducted during the Hajj in 2016 on patients who presented to emergency departments and were diagnosed with heat exhaustion or heatstroke. Data were collected using a structured collection sheet developed based on the literature...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29658833/gonadopenia-and-aging-in-men
#19
Sandeep Singh Dhindsa, Michael S Irwig, Kathleen Wyne
OBJECTIVE: The decrease in testosterone levels that occurs with aging has become an important clinical issue both due to the growth of the geriatric population and patient interest in testosterone therapy. The decision to assess for testosterone deficiency and the ability to determine whether the benefits exceed the risks require a comprehensive evaluation of the aging patient. This article is part of a series of papers focused on the endocrinology of aging. This review addresses common issues needed for clinical decision making, including how to interpret test results, differential diagnosis, potential impact of testosterone treatment on insulin resistance and cardiovascular disease, and options for therapy...
April 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29657211/etiological-profile-of-chronic-kidney-disease-a-single-center-retrospective-hospital-based-study
#20
Manjuri Sharma, Prodip Doley, Himanab Jyoti Das
Chronic kidney disease (CKD) is one of the leading causes of chronic diseases globally, with rising incidence and prevalence. It is a major risk factor for cerebrovascular disease and coronary artery disease, which are the main causes of death in this population. The etiology of CKD is varied. This study was performed to evaluate the various etiologies of CKD among patients presenting to the Department of Nephrology, Guwahati Medical College, a tertiary referral center. A total of 5718 CKD patients were evaluated to identify the cause of CKD...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
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