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Diabetes mellitus prevention

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https://www.readbyqxmd.com/read/29907995/fifteen-years-of-life-losartan-intervention-for-endpoint-reduction-in-hypertension-lessons-learned-for-losartan-an-old-dog-playing-good-tricks
#1
REVIEW
Niki Katsiki, Konstantinos Tsioufis, Dilek Ural, Massimo Volpe
There is an unmet need to prevent cardiovascular disease and chronic kidney disease development and progression worldwide. Losartan, the first angiotensin receptor blocker, was shown to exert significant cardioprotective and renoprotective effects in the LIFE (Losartan Intervention for Endpoint Reduction in Hypertension) and RENAAL (Reduction of Endpoints in NIDDM With the Angiotensin II Antagonist Losartan) trials. Losartan significantly prevented stroke and decreased serum uric acid levels and the rates of new-onset diabetes mellitus and atrial fibrillation...
June 15, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29906751/resveratrol-promotes-neuroprotection-and-attenuates-oxidative-and-nitrosative-stress-in-the-small-intestine-in-diabetic-rats
#2
Paulo Emilio Botura Ferreira, Evandro José Beraldi, Stephanie Carvalho Borges, Maria Raquel Marçal Natali, Nilza Cristina Buttow
Damages to the enteric nervous system caused by diabetes mellitus (DM) are frequently attributed to oxidative and nitrosative stress. We aimed to investigate the effect of Resveratrol (RSV) (10 mg/kg) on oxidative and nitrosative stress in the intestinal wall and morphoquantitative aspects of the myenteric plexus of the duodenum, jejunum and ileum in diabetic rats. Twenty-four rats were distributed into four groups (n = 6/group): control (C group), control treated with RSV (CR group), diabetic (D group), and diabetic treated with RSV (DR group) for 120 days...
June 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29903525/impacts-of-self-management-education-on-glycaemic-control-in-patients-with-type-2-diabetes-mellitus
#3
Deldar Morad Abdulah, Alan Bapeer Hassan, Farsat Saeed Saadi, Ary Habeeb Mohammed
OBJECTIVES: Dietary and physical activity advice have been considered to be seminal ingredients in prevention and management of type 2 diabetes mellitus. In this regard, the impacts of a three-month self-management intervention on glycemic control in patients with type 2 diabetes were examined in the present study. STUDY DESIGN: A Double-arm post-test intervention study. METHODS: In the current post-test intervention study, three two-hour educational sessions on dietary habits and physical activity designed according to Health Belief Model were presented to 16 non-complicated type 2 diabetic patients and their dietary, physical activities, and biochemical outcomes were compared to a 23 patient-control arm in Iraq in 2017...
June 7, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29902224/premorbid-risk-perception-lifestyle-adherence-and-coping-strategies-of-people-with-diabetes-mellitus-a-phenomenological-study-in-the-brong-ahafo-region-of-ghana
#4
Philip Teg-Nefaah Tabong, Vitalis Bawontuo, Doris Ningwiebe Dumah, Joseph Maaminu Kyilleh, Tolgou Yempabe
BACKGROUND: One of the non-communicable diseases which is on the rise is type 2 diabetes (T2D). T2D is largely preventable with healthy lifestyle. We therefore conducted this study to explore premorbid perception of risk, behavioural practices and the coping strategies of patients with T2D. METHODS: Using descriptive phenomenology approach to qualitative enquiry, we conducted eight focus group discussions (N = 73) with diabetic patients; four among males (N = 36) and four among females (N = 37)...
2018: PloS One
https://www.readbyqxmd.com/read/29900143/long-chain-n-3-fatty-acids-improve-depression-syndrome-in-type-2-diabetes-mellitus
#5
Maryam Mazaherioun, Ahmad Saedisomeolia, Mohammad Hassan Javanbakht, Fariba Koohdani, Mahnaz Zarei, Samaneh Ansari, Fatemeh Khoshkhoo Bazargani, Mahmoud Djalali
Background: Type 2 diabetes mellitus (T2DM) is commonly associated with depressive symptoms, which affect prognosis and quality of life. We investigated the antidepressant effects of n-3 fatty acids (n-3FAs) monotherapy (without conventional antidepressants) for T2DM patients with mild to moderate depressive symptoms. Methods: A 10-wk, placebo-controlled, double-blind, parallel-group (1:1 ratio) randomized trial of n-3FAs (2700 mg/day EPA: DHA ratio=2) versus placebo in 88 Iranian diabetic patients with mild to moderate depression based on Beck Depression Inventory II (BDI-II-PERSIAN) was conducted...
April 2018: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29899044/human-genetics-of-obesity-and-type-2-diabetes-mellitus-past-present-and-future
#6
REVIEW
Erik Ingelsson, Mark I McCarthy
Type 2 diabetes mellitus (T2D) and obesity already represent 2 of the most prominent risk factors for cardiovascular disease, and are destined to increase in importance given the global changes in lifestyle. Ten years have passed since the first round of genome-wide association studies for T2D and obesity. During this decade, we have witnessed remarkable developments in human genetics. We have graduated from the despair of candidate gene-based studies that generated few consistently replicated genotype-phenotype associations, to the excitement of an exponential harvest of loci robustly associated with medical outcomes through ever larger genome-wide association study meta-analyses...
June 2018: Circulation. Genomic and precision medicine
https://www.readbyqxmd.com/read/29898442/a-novel-early-pregnancy-risk-prediction-model-for-gestational-diabetes-mellitus
#7
Arianne N Sweeting, Jencia Wong, Heidi Appelblom, Glynis P Ross, Heikki Kouru, Paul F Williams, Mikko Sairanen, Jon A Hyett
INTRODUCTION: Accurate early risk prediction for gestational diabetes mellitus (GDM) would target intervention and prevention in women at the highest risk. We evaluated novel biomarker predictors to develop a first-trimester risk prediction model in a large multiethnic cohort. METHODS: Maternal clinical, aneuploidy and pre-eclampsia screening markers (PAPP-A, free hCGβ, mean arterial pressure, uterine artery pulsatility index) were measured prospectively at 11-13+6 weeks' gestation in 980 women (248 with GDM; 732 controls)...
June 13, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29896313/diabetes-care-in-figures-current-pitfalls-and-future-scenario
#8
REVIEW
Alexandre Assuane Duarte, Shahriar Mohsin, Olga Golubnitschaja
Diabetes mellitus (DM) epidemic-on a global scale-is a major and snowballing threat to public health, healthcare systems and economy, due to the cascade of pathologies triggered in a long-term manner after the DM manifestation. There are remarkable differences in the geographic disease spread and acceleration of an increasing DM prevalence recorded. Specifically, the highest initial prevalence of DM was recorded in the Eastern-Mediterranean region in 1980 followed by the highest acceleration of the epidemic characterised by 0...
June 2018: EPMA Journal
https://www.readbyqxmd.com/read/29896075/sweetener-content-and-cariogenic-potential-of-pediatric-oral-medications-a-literature
#9
REVIEW
Jehan Al Humaid
Sweetened oral medications are widely used for children to facilitate compliance. A variety of natural and artificial sweeteners are used in these drug formulations to augment the sweetness and thereby palatability of the product. There is growing concern among dentists about the increased consumption of sugars in these medications by children, especially those who are chronically ill as it may contribute to diabetes mellitus, dental erosion, and dental caries. This literature review provides information about the sweetener content and cariogenic potential of commonly prescribed pediatric oral medications that are used for managing acute and chronic conditions in children and measures for oral health prevention...
May 2018: International Journal of Health Sciences
https://www.readbyqxmd.com/read/29895330/rationale-and-design-of-study-of-dapagliflozin-versus-sitagliptin-treatment-efficacy-on-prevention-of-cardiovascular-risk-factors-in-type-2-diabetes-patients-the-diversity-cvr-study
#10
Fumika Shigiyama, Naoki Kumashiro, Ayako Fuchigami, Takahisa Hirose
BACKGROUND: Recent studies reported that sodium glucose cotransporter 2 (SGLT2) inhibitors reduced the cardiovascular morbidity and mortality in patients with type 2 diabetes mellitus (T2DM) compared to placebo in contrast to no reduction with dipeptidyl peptidase 4 (DPP4) inhibitors. However, there are no comparative studies on the effects of SGLT2 inhibitors and DPP4 inhibitors on HbA1c, body weight and hypoglycemia as risk factors of cardiovascular diseases. The aim of the present ongoing study is to compare the effects of dapagliflozin, a SGLT2 inhibitor, with those of sitagliptin, a DPP4 inhibitor, on cardiovascular risk factors in T2DM patients with inadequate glycemic control...
June 12, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29890554/the-effect-of-metformin-therapy-for-preventing-gestational-diabetes-mellitus-in-women-with-polycystic-ovary-syndrome-a-meta-analysis
#11
Jing Zhao, Xiaoyan Liu, Wenhua Zhang
OBJECTIVE: This study was to analyze the efficacy of metformin intervention in preventing gestational diabetes mellitus (GDM). METHODS: A systematic review and meta-analysis of clinical trials or observational studies of metformin intervention in preventing symptoms of GDM during pregnancy were performed. Medline, Embase, and Cochrane Library were searched through to now. The main evaluated primary outcomes were incident of GDM, miscarriage, preterm delivery, and neonatal mortality...
June 11, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29889746/postpartum-testing-to-detect-persistent-dysglycemia-in-women-with-gestational-diabetes-mellitus
#12
Michael P Carson, Cande V Ananth, Cynthia Gyamfi-Bannerman, John Smulian, Ronald J Wapner
The rate of gestational diabetes has doubled, and identifying the 30% with persistent postpartum dysglycemia (prediabetes or diabetes mellitus) is important because low-cost interventions have been proven to prevent overt diabetes mellitus, improve health for women, and potentially decrease the risk for birth defects in future pregnancies. Consensus guidelines continue to recommend a 4- to 12-week postpartum 2-hour oral glucose tolerance test (OGTT) despite persistent reports that only 35% of women complete the test...
June 6, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29888950/comparison-of-amlodipine-versus-other-calcium-channel-blockers-on-blood-pressure-variability-in-hypertensive-patients-in-china-a-retrospective-propensity-score-matched-analysis
#13
Lin Zhang, JinKui Yang, LanTing Li, DongDong Liu, XiaoPing Xie, Peng Dong, Yong Lin
AIM: Reducing the fluctuation of blood pressure has recently been recognized as a potential target for improving management of hypertension to prevent cardiovascular events, particularly for strokes. Some randomized controlled trials demonstrated that amlodipine can effectively reduce blood pressure as a well-established, long-acting calcium channel blocker (CCB). However, few data are available for amlodipine on blood pressure variability (BPV) in China in a real-world setting. This study aimed to assess the effect of amlodipine versus other CCB antihypertensive agents on BPV...
June 11, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/29888323/circulating-neurotoxic-5-ht2a-receptor-agonist-autoantibodies-in-adult-type-2-diabetes-with-parkinson-s-disease
#14
Mark B Zimering
Aims: To test whether circulating neurotoxic autoantibodies increase in adult type 2 diabetes mellitus with Parkinson's disease (PD) or dementia. To identify the G-protein coupled receptor on neuroblastoma cells mediating neural inhibitory effects in diabetic Parkinson's disease plasma autoantibodies. To determine the mechanism of accelerated neuroblastoma cell death and acute neurite retraction induced by diabetic Parkinson's disease and dementia autoantibodies. Methods: Protein-A eluates from plasma of twelve older adult male diabetic patients having Parkinson's disease (n=10) or dementia (n=2), and eight age-matched control diabetic patients were tested for ability to cause accelerated N2A neuroblastoma cell death and acute neurite retraction...
2018: Journal of Endocrinology and Diabetes
https://www.readbyqxmd.com/read/29887923/comorbidity-and-intercurrent-diseases-in-geriatric-stroke-rehabilitation-a-multicentre-observational-study-in-skilled-nursing-facilities
#15
Anouk D Kabboord, Monica Van Eijk, Bianca I Buijck, Raymond T C M Koopmans, Romke van Balen, Wilco P Achterberg
Background: Older patients often have multiple comorbidities and are susceptible to develop intercurrent diseases during rehabilitation. This study investigates intercurrent diseases and associated factors in patients undergoing geriatric stroke rehabilitation, focussing on pre-existing comorbid conditions, overall comorbidity and baseline functional status. Materials and methods: This multicentre prospective cohort study included 15 skilled nursing facilities. Data were collected at baseline and at discharge...
2018: European Geriatric Medicine
https://www.readbyqxmd.com/read/29887834/diabetes-mellitus-and-infertility-different-pathophysiological-effects-in-type-1-and-type-2-on-sperm-function
#16
Rosita A Condorelli, Sandro La Vignera, Laura M Mongioì, Angela Alamo, Aldo E Calogero
Although the prevalence of sub-infertility in diabetic patients in childbearing age is known, the mechanisms by which diabetes mellitus (DM) causes male infertility are not completely explained. This detrimental effect is achieved with a variety of mechanisms that include pre-testicular, testicular, and post-testicular pathogenetic moments and can be different in type 1 diabetes mellitus (DM1) and type 2 diabetes mellitus (DM2) patients because of type of diabetes, duration of disease, and glycemic metabolic compensation...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29885537/impact-of-obesity-on-autoimmune-arthritis-and-its-cardiovascular-complications
#17
REVIEW
Katrien Van Raemdonck, Sadiq Umar, Zoltán Szekanecz, Ryan K Zomorrodi, Shiva Shahrara
Obesity can instigate and sustain a systemic low-grade inflammatory environment that can amplify autoimmune disorders and their associated comorbidities. Metabolic changes and inflammatory factors produced by the adipose tissue have been reported to aggravate autoimmunity and predispose the patient to cardiovascular disease (CVD) and metabolic comorbidities. Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are autoimmune arthritic diseases, often linked with altered body mass index (BMI). Severe joint inflammation and bone destruction have a debilitating impact on the patient's life; there is also a staggering risk of cardiovascular morbidity and mortality...
June 6, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29885108/effect-of-empagliflozin-a-selective-sodium-glucose-cotransporter-2-inhibitor-on-kidney-and-peripheral-nerves-in-streptozotocin-induced-diabetic-rats
#18
Kyung Ae Lee, Heung Yong Jin, Na Young Lee, Yu Ji Kim, Tae Sun Park
The effect of sodium-glucose cotransporter 2 inhibitors on peripheral nerves and kidneys in diabetes mellitus (DM) remains unexplored. Therefore, this study aimed to explore the effect of empagliflozin in diabetic rats. DM in rats was induced by streptozotocin injection, and diabetic rats were treated with empagliflozin 3 or 10 mg/kg. Following 24-week treatment, response thresholds to four different stimuli were tested and found to be lower in diabetic rats than in normal rats. Empagliflozin significantly prevented hypersensitivity (P<0...
April 25, 2018: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/29884657/cluster-randomized-trial-to-evaluate-a-centralized-clinical-pharmacy-service-in-private-family-medicine-offices
#19
Barry L Carter, Barcey Levy, Brian Gryzlak, Yinghui Xu, Elizabeth Chrischilles, Jeffrey Dawson, Mark Vander Weg, Alan Christensen, Paul James, Linnea Polgreen
BACKGROUND: The use of clinical pharmacists in primary care has improved the control of several chronic cardiovascular conditions. However, many private physician practices lack the resources to implement team-based care with pharmacists. The purpose of this study was to evaluate whether a centralized, remote, clinical pharmacy service could improve guideline adherence and secondary measures of cardiovascular risk in primary care offices in rural and small communities. METHODS AND RESULTS: This study was a prospective trial in 12 family medicine offices cluster randomized to either the intervention or usual care...
June 2018: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29882903/the-emerging-role-of-biomarkers-in-the-diagnosis-of-gestational-diabetes-mellitus
#20
REVIEW
Natassia Rodrigo, Sarah J Glastras
Gestational diabetes mellitus (GDM) is a common complication of pregnancy; its rising incidence is a result of increased maternal obesity and older maternal age together with altered diagnostic criteria identifying a greater proportion of pregnant women with GDM. Its consequences are far-reaching, associated with poorer maternal and neonatal outcomes compared to non-GDM pregnancies, and GDM has implications for metabolic health in both mother and offspring. Objective markers to identify women at high risk for the development of GDM are useful to target therapy and potentially prevent its development...
May 23, 2018: Journal of Clinical Medicine
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