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https://www.readbyqxmd.com/read/28345255/lichenoid-folliculitis-a-unifying-concept
#1
Mamina M Turegano, Leonard C Sperling
Skin diseases presenting with keratotic papules, atrophy, cicatricial alopecia, and/or "lichenoid" histopathologic changes have been described under at least 30 names. This family of diseases contains two subgroups, largely based on clinical features: keratosis pilaris atrophicans (KPA; including keratosis pilaris atrophicans faciei/ulerythema ophryogenes, atrophoderma vermiculata , and keratosis follicularis spinulosa decalvans); and the lichen planopilaris (LPP) subgroup (including LPP, frontal fibrosing alopecia, Graham-Little-Piccardi-Lassueur Syndrome, and fibrosing alopecia in a pattern distribution)...
March 26, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28343962/contextually-mediated-spontaneous-retrieval-is-specific-to-the-hippocampus
#2
Nicole M Long, Michael R Sperling, Gregory A Worrell, Kathryn A Davis, Robert E Gross, Bradley C Lega, Barbara C Jobst, Sameer A Sheth, Kareem Zaghloul, Joel M Stein, Michael J Kahana
Although it is now well established that the hippocampus supports memory encoding [1, 2], little is known about hippocampal activity during spontaneous memory retrieval. Recent intracranial electroencephalographic (iEEG) work has shown that hippocampal activity during encoding predicts subsequent temporal organization of memories [3], supporting a role in contextual binding. It is an open question, however, whether the hippocampus similarly supports contextually mediated processes during retrieval. Here, we analyzed iEEG recordings obtained from 215 epilepsy patients as they performed a free recall task...
March 8, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28335018/dissecting-gamma-frequency-activity-during-human-memory-processing
#3
Michal T Kucewicz, Brent M Berry, Vaclav Kremen, Benjamin H Brinkmann, Michael R Sperling, Barbara C Jobst, Robert E Gross, Bradley Lega, Sameer A Sheth, Joel M Stein, Sandthitsu R Das, Richard Gorniak, S Matthew Stead, Daniel S Rizzuto, Michael J Kahana, Gregory A Worrell
Gamma frequency activity (30-150 Hz) is induced in cognitive tasks and is thought to reflect underlying neural processes. Gamma frequency activity can be recorded directly from the human brain using intracranial electrodes implanted in patients undergoing treatment for drug-resistant epilepsy. Previous studies have independently explored narrowband oscillations in the local field potential and broadband power increases. It is not clear, however, which processes contribute to human brain gamma frequency activity, or their dynamics and roles during memory processing...
March 13, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28283594/cued-memory-decline-in-biomarker-defined-preclinical-alzheimer-disease
#4
Kathryn V Papp, Dorene M Rentz, Elizabeth C Mormino, Aaron P Schultz, Rebecca E Amariglio, Yakeel Quiroz, Keith A Johnson, Reisa A Sperling
OBJECTIVE: To determine whether a decline in cued recall is observable in the preclinical stage of Alzheimer disease (AD) in clinically normal older adults with elevated β-amyloid (Aβ) burden on PET imaging. METHODS: Clinically normal older adults underwent baseline neuroimaging (PET to assess Aβ(+/-) status and MRI) and annual neuropsychological testing. Cox proportional hazards models were used to assess the relative risk of cued memory decline (drop of 1, 2, 3, or 4 points on the total score of the Free and Cued Selective Reminding Test) in relation to neuroimaging measures, functional status, age, sex, and education...
March 10, 2017: Neurology
https://www.readbyqxmd.com/read/28276064/instruction-manual-for-the-ilae-2017-operational-classification-of-seizure-types
#5
Robert S Fisher, J Helen Cross, Carol D'Souza, Jacqueline A French, Sheryl R Haut, Norimichi Higurashi, Edouard Hirsch, Floor E Jansen, Lieven Lagae, Solomon L Moshé, Jukka Peltola, Eliane Roulet Perez, Ingrid E Scheffer, Andreas Schulze-Bonhage, Ernest Somerville, Michael Sperling, Elza Márcia Yacubian, Sameer M Zuberi
This companion paper to the introduction of the International League Against Epilepsy (ILAE) 2017 classification of seizure types provides guidance on how to employ the classification. Illustration of the classification is enacted by tables, a glossary of relevant terms, mapping of old to new terms, suggested abbreviations, and examples. Basic and extended versions of the classification are available, depending on the desired degree of detail. Key signs and symptoms of seizures (semiology) are used as a basis for categories of seizures that are focal or generalized from onset or with unknown onset...
March 8, 2017: Epilepsia
https://www.readbyqxmd.com/read/28271960/performance-evaluation-of-a-natural-treatment-system-for-small-communities-composed-of-a-uasb-reactor-maturation-ponds-baffled-and-unbaffled-and-a-granular-rock-filter-in-series
#6
D F C Dias, R G Passos, V A J Rodrigues, M P de Matos, C R S Santos, M von Sperling
Post-treatment of anaerobic reactor effluent with maturation ponds is a good option for small to medium-sized communities in tropical climates. The treatment line investigated, operating in Brazil, with an equivalent capacity to treat domestic sewage from 250 inhabitants, was comprised of a UASB reactor followed by two shallow maturation ponds (unbaffled and baffled) and a granular rock filter (decreasing grain size) in series, requiring an area of only 1.5 m(2).inhabitant(-1). With an overall hydraulic retention time of only 6...
March 8, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28253546/fdg-metabolism-associated-with-tau-amyloid-interaction-predicts-memory-decline
#7
Bernard J Hanseeuw, Rebecca A Betensky, Aaron P Schultz, Kate V Papp, Elizabeth C Mormino, Jorge Sepulcre, John S Bark, Danielle M Cosio, Molly LaPoint, Jasmeer P Chhatwal, Dorene M Rentz, Reisa A Sperling, Keith Johnson
OBJECTIVE: To evaluate in normal older adults and preclinical Alzheimer's disease (AD) the impact of amyloid and regional tauopathy on cerebral glucose metabolism and subsequent memory decline. METHODS: We acquired positron emission tomography using F18 Flortaucipir (tau), C11 Pittsburgh Compound B (amyloid) and F18 Fluorodeoxyglucose in 90 clinically normal elderly of the Harvard Aging Brain Study. RESULTS: Posterior cingulate metabolism decreased when both amyloid and neocortical tau were high and predicted subsequent memory decline in a larger sample of normal elderly...
March 2, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28253478/early-and-late-change-on-the-preclinical-alzheimer-s-cognitive-composite-in-clinically-normal-older-individuals-with-elevated-amyloid-%C3%AE
#8
Elizabeth C Mormino, Kathryn V Papp, Dorene M Rentz, Michael C Donohue, Rebecca Amariglio, Yakeel T Quiroz, Jasmeer Chhatwal, Gad A Marshall, Nancy Donovan, Jonathan Jackson, Jennifer R Gatchel, Bernard J Hanseeuw, Aaron P Schultz, Paul S Aisen, Keith A Johnson, Reisa A Sperling
INTRODUCTION: Sensitive detection of cognitive decline over the course of preclinical Alzheimer's disease is critical as the field moves toward secondary prevention trials. METHODS: We examined amyloid-β (Aβ)-related change in several variations of the preclinical Alzheimer cognitive composite (PACC) and each individual PACC component in clinically normal (CN) older participants in the Harvard Aging Brain Study. We then examined the PACC variations in the Alzheimer's Disease Cooperative Study Prevention Instrument Study as a replication cohort...
February 28, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28243661/reversible-dna-micro-patterning-using-the-fluorous-effect
#9
Gabriella E Flynn, Jamie M Withers, Gerard Macias, Justin R Sperling, Sarah L Henry, Jonathan M Cooper, Glenn A Burley, Alasdair W Clark
We describe a new method for the immobilisation of DNA into defined patterns with sub-micron resolution, using the fluorous effect. The method is fully reversible via a simple solvent wash, allowing the patterning, regeneration and re-patterning of surfaces with no degradation in binding efficiency following multiple removal/attachment cycles of different DNA sequences.
February 28, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28236572/comparison-of-bacterial-16s-rrna-variable-regions-for-microbiome-surveys-of-ticks
#10
Janet L Sperling, K L Silva-Brandão, M M Brandão, V K Lloyd, S Dang, C S Davis, F A H Sperling, K E Magor
Ticks vector diverse pathogenic bacteria that are important to identify in public health and veterinary contexts. Technological advances in high throughput sequencing have given an unprecedented opportunity to comprehensively characterize bacterial associates of ticks, but recent studies have used different 16S rRNA variable regions and sequence read lengths with little consideration of whether they reveal the same bacterial diversity. We compare the effectiveness of bacterial surveys using three library preparations across nine 16S variable regions and a set of 12 tick specimens (Acari: Ixodidae)...
February 9, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28231417/genetic-and-genomic-evidence-of-niche-partitioning-and-adaptive-radiation-in-mountain-pine-beetle-fungal-symbionts
#11
Dario I Ojeda Alayon, Clement K M Tsui, Nicolas Feau, Arnaud Capron, Braham Dhillon, Yiyuan Zhang, Sepideh Massoumi Alamouti, Celia K Boone, Allan L Carroll, Janice E K Cooke, Amanda D Roe, Felix A H Sperling, Richard C Hamelin
Bark beetles form multipartite symbiotic associations with blue stain fungi (Ophiostomatales, Ascomycota). These symbionts play an important role during the beetle's life cycle by providing nutritional supplementation, overcoming tree defenses and modifying host tissues to favor brood development. The maintenance of stable multipartite symbioses with seemingly less competitive symbionts in similar habitats is of fundamental interest to ecology and evolution. We tested the hypothesis that the coexistence of three fungal species associated with the mountain pine beetle is the result of niche partitioning and adaptive radiation using SNP genotyping coupled with genotype-environment association analysis and phenotypic characterization of growth rate under different temperatures...
February 23, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28207335/housing-assistance-programs-and-adult-health-in-the-united-states
#12
Andrew Fenelon, Patrick Mayne, Alan E Simon, Lauren M Rossen, Veronica Helms, Patricia Lloyd, Jon Sperling, Barry L Steffen
OBJECTIVES: To examine whether access to housing assistance is associated with better health among low-income adults. METHODS: We used National Health Interview Survey data (1999-2012) linked to US Department of Housing and Urban Development (HUD) administrative records (1999-2014) to examine differences in reported fair or poor health and psychological distress. We used multivariable models to compare those currently receiving HUD housing assistance (public housing, housing choice vouchers, and multifamily housing) with those who will receive housing assistance within 2 years (the average duration of HUD waitlists) to account for selection into HUD assistance...
April 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28159228/isobaric-dilution-analysis-as-a-calibration-tool-for-long-lived-radionuclides-in-icp-ms
#13
David Clases, Marvin Birka, Michael Sperling, Andreas Faust, Uwe Karst
A novel quantification method named isobaric dilution analysis (IBDA) is introduced for internal calibration using inductively coupled plasma mass spectrometry (ICP-MS). Unlike isotope dilution analysis (IDA), where a sample to be analysed for a target analyte element is spiked with an isotopically enriched solution of the same element, IBDA uses the fact that conventional mass analysers cannot distinguish between two isobaric isotopes of different elements. Therefore, in IBDA, the sample with the element of interest is spiked with a solution of a different element, which shares at least one isobaric isotope and shows similar chemical properties resulting in a similar response...
March 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28094177/cognitive-outcomes-after-coronary-artery-bypass-grafting
#14
REVIEW
Deepak Bhamidipati, Jordan E Goldhammer, Michael R Sperling, Marc C Torjman, Melissa M McCarey, David J Whellan
No abstract text is available yet for this article.
September 28, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28060054/patient-reported-and-objectively-measured-function-before-and-after-reverse-shoulder-arthroplasty
#15
Wendy J Hurd, Melissa M Morrow, Emily J Miller, Robert A Adams, John W Sperling, Kenton R Kaufman
BACKGROUND AND PURPOSE: Documenting functional outcomes after reverse shoulder arthroplasty (RSA) is critical to advancing patient care. The interplay been self-reported and objectively measured outcome measures has not been widely described. The utilization of wearable devices to document upper extremity limb activity is a new approach for objectively measuring outcomes. Therefore, the purpose of this study was to evaluate changes in pain, and self-reported function and objectively measured limb activity after RSA...
January 5, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/28054081/imaging-metals-in-caenorhabditis-elegans
#16
REVIEW
M Aschner, C Palinski, M Sperling, U Karst, T Schwerdtle, J Bornhorst
Systemic trafficking and storage of essential metal ions play fundamental roles in living organisms by serving as essential cofactors in various cellular processes. Thereby metal quantification and localization are critical steps in understanding metal homeostasis, and how their dyshomeostasis might contribute to disease etiology and the ensuing pathologies. Furthermore, the amount and distribution of metals in organisms can provide insight into their underlying mechanisms of toxicity and toxicokinetics. While in vivo studies on metal imaging in mammalian experimental animals are complex, time- and resource-consuming, the nematode Caenorhabditis elegans (C...
January 5, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28007989/cad-mutations-and-uridine-responsive-epileptic-encephalopathy
#17
Johannes Koch, Johannes A Mayr, Bader Alhaddad, Christian Rauscher, Jörgen Bierau, Reka Kovacs-Nagy, Karlien L M Coene, Ingrid Bader, Monika Holzhacker, Holger Prokisch, Hanka Venselaar, Ron A Wevers, Felix Distelmaier, Tilman Polster, Steffen Leiz, Cornelia Betzler, Tim M Strom, Wolfgang Sperl, Thomas Meitinger, Saskia B Wortmann, Tobias B Haack
Unexplained global developmental delay and epilepsy in childhood pose a major socioeconomic burden. Progress in defining the molecular bases does not often translate into effective treatment. Notable exceptions include certain inborn errors of metabolism amenable to dietary intervention. CAD encodes a multifunctional enzyme involved in de novo pyrimidine biosynthesis. Alternatively, pyrimidines can be recycled from uridine. Exome sequencing in three families identified biallelic CAD mutations in four children with global developmental delay, epileptic encephalopathy, and anaemia with anisopoikilocytosis...
December 21, 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/27992822/thrombolytic-treatment-to-stroke-mimic-patients-via-telestroke
#18
Ganesh Asaithambi, Amy L Castle, Michael A Sperl, Jayashree Ravichandran, Aditi Gupta, Bridget M Ho, Sandra K Hanson
OBJECTIVE: The safety and outcomes of intravenous thrombolysis (IVT) to stroke patients via telestroke (TS) is similar to those presenting to stroke centers. Little is known on the accuracy of TS diagnosis among those receiving IVT. We sought to compare the rate of patients receiving IVT with diagnosis of ischemic stroke as opposed to stroke mimic (SM) in our TS network to those who presented to our comprehensive stroke center (CSC). MATERIALS AND METHODS: Consecutive patients receiving IVT between August 2014 and June 2015 were identified at our CSC and TS network...
February 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27989841/cardiorespiratory-fitness-is-differentially-associated-with-cortical-thickness-in-young-and-older-adults
#19
Victoria J Williams, Jasmeet P Hayes, Daniel E Forman, David H Salat, Reisa A Sperling, Mieke Verfaellie, Scott M Hayes
Aging is associated with reductions in gray matter volume and cortical thickness. One factor that may play a role in mitigating age-associated brain decline is cardiorespiratory fitness (CRF). Although previous work has identified a positive association between CRF and gray matter volume, the relationship between CRF and cortical thickness, which serves as a more sensitive indicator of gray matter integrity, has yet to be assessed in healthy young and older adults. To address this gap in the literature, 32 young and 29 older adults completed treadmill-based progressive maximal exercise testing to assess CRF (peak VO2), and structural magnetic resonance imaging (MRI) to determine vertex-wise surface-based cortical thickness metrics...
February 1, 2017: NeuroImage
https://www.readbyqxmd.com/read/27981905/natural-approaches-in-diabetes-management-a-review-of-diet-exercise-and-natural-products
#20
William M Schultz, Tina Varghese, Robert E Hein, Devinder S Dhindsa, Elliot N Mahlof, Hannah C Cai, Geoffrey Southmayd, Pratik B Sandesaraa, Danny J Eapen, Laurence S Sperling
Diabetes mellitus (DM) is a highly prevalent condition that causes significant morbidity and mortality in the United States and worldwide. Conventional therapies include lifestyle modification, oral pharmacological agents, and subcutaneous insulin. Emerging data suggest that natural approaches to the treatment of DM may help supplement current therapies for further glycemic control. Herein, we review the evidence of several natural modalities for DM treatment. We describe the pathophysiology of diabetes and its complications, provide an overview of current pharmacologic treatments, and finally, discuss natural approaches to diabetes management...
December 16, 2016: Current Pharmaceutical Design
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