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https://www.readbyqxmd.com/read/28504297/elemental-bioimaging-by-means-of-la-icp-oes-investigation-of-the-calcium-sodium-and-potassium-distribution-in-tobacco-plant-stems-and-leaf-petioles
#1
G M Thyssen, M Holtkamp, H Kaulfürst-Soboll, C A Wehe, M Sperling, A von Schaewen, U Karst
Laser ablation-inductively coupled plasma-optical emission spectroscopy (LA-ICP-OES) is presented as a valuable tool for elemental bioimaging of alkali and earth alkali elements in plants. Whereas LA-ICP-OES is commonly used for micro analysis of solid samples, laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) has advanced to the gold standard for bioimaging. However, especially for easily excitable and ubiquitous elements such as alkali and earth alkali elements, LA-ICP-OES holds some advantages regarding simultaneous detection, costs, contamination, and user-friendliness...
May 15, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28491280/ar2-a-novel-automatic-artifact-reduction-software-method-for-ictal-eeg-interpretation-validation-and-comparison-of-performance-with-commercially-available-software
#2
Shennan Aibel Weiss, Ali A Asadi-Pooya, Sitaram Vangala, Stephanie Moy, Dale H Wyeth, Iren Orosz, Michael Gibbs, Lara Schrader, Jason Lerner, Christopher K Cheng, Edward Chang, Rajsekar Rajaraman, Inna Keselman, Perdro Churchman, Christine Bower-Baca, Adam L Numis, Michael G Ho, Lekha Rao, Annapoorna Bhat, Joanna Suski, Marjan Asadollahi, Timothy Ambrose, Andres Fernandez, Maromi Nei, Christopher Skidmore, Scott Mintzer, Dawn S Eliashiv, Gary W Mathern, Marc R Nuwer, Michael Sperling, Jerome Engel, John M Stern
Objective: To develop a novel software method (AR2) for reducing muscle contamination of ictal scalp electroencephalogram (EEG), and validate this method on the basis of its performance in comparison to a commercially available software method (AR1) to accurately depict seizure-onset location. Methods: A blinded investigation used 23 EEG recordings of seizures from 8 patients. Each recording was uninterpretable with digital filtering because of muscle artifact and processed using AR1 and AR2 and reviewed by 26 EEG specialists...
2017: F1000Research
https://www.readbyqxmd.com/read/28488693/icos-protects-against-mortality-from-acute-lung-injury-through-activation-of-il-5-ilc2s
#3
C L Hrusch, S T Manns, D Bryazka, J Casaos, C A Bonham, M R Jaffery, K M Blaine, K A M Mills, P A Verhoef, A O Adegunsoye, J W Williams, M Y Tjota, T V Moore, M E Strek, I Noth, A I Sperling
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease causing irreversible lung scarring and loss of pulmonary function. IPF Patients suffer from a high rate of pulmonary infections and acute exacerbations of disease that further contribute to pulmonary decline. Low expression of the inducible T-cell costimulatory molecule (ICOS) in peripheral blood mononuclear cells predicts decreased survival of IPF patients, but the mechanisms by which ICOS protects are unclear. Using a model of bleomycin-induced lung injury and fibrosis, we now demonstrate that ICOS expression enhances survival from lung injury rather than regulating fibrogenesis...
May 10, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28474918/detector-independent-verification-of-quantum-light
#4
J Sperling, W R Clements, A Eckstein, M Moore, J J Renema, W S Kolthammer, S W Nam, A Lita, T Gerrits, W Vogel, G S Agarwal, I A Walmsley
We introduce a method for the verification of nonclassical light which is independent of the complex interaction between the generated light and the material of the detectors. This is accomplished by means of a multiplexing arrangement. Its theoretical description yields that the coincidence statistics of this measurement layout is a mixture of multinomial distributions for any classical light field and any type of detector. This allows us to formulate bounds on the statistical properties of classical states...
April 21, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28472627/neuroimaging-markers-associated-with-maintenance-of-optimal-memory-performance-in-late-life
#5
Maria Dekhtyar, Kathryn V Papp, Rachel Buckley, Heidi I L Jacobs, Aaron P Schultz, Keith A Johnson, Reisa A Sperling, Dorene M Rentz
BACKGROUND: Age-related memory decline has been well-documented; however, some individuals reach their 8th-10th decade while maintaining strong memory performance. OBJECTIVE: To determine which demographic and biomarker factors differentiated top memory performers (aged 75+, top 20% for memory) from their peers and whether top memory performance was maintained over 3 years. METHODS: Clinically normal adults (n=125, CDR=0; age: 79.5±3.57 years) from the Harvard Aging Brain Study underwent cognitive testing and neuroimaging (amyloid PET, MRI) at baseline and 3-year follow-up...
May 1, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28450713/decreased-body-mass-index-in-the-preclinical-stage-of-autosomal-dominant-alzheimer-s-disease
#6
Stephan Müller, Oliver Preische, Hamid R Sohrabi, Susanne Gräber, Mathias Jucker, Janko Dietzsch, John M Ringman, Ralph N Martins, Eric McDade, Peter R Schofield, Bernardino Ghetti, Martin Rossor, Neill R Graff-Radford, Johannes Levin, Douglas Galasko, Kimberly A Quaid, Stephen Salloway, Chengjie Xiong, Tammie Benzinger, Virginia Buckles, Colin L Masters, Reisa Sperling, Randall J Bateman, John C Morris, Christoph Laske
The relationship between body-mass index (BMI) and Alzheimer´s disease (AD) has been extensively investigated. However, BMI alterations in preclinical individuals with autosomal dominant AD (ADAD) have not yet been investigated. We analyzed cross-sectional data from 230 asymptomatic members of families with ADAD participating in the Dominantly Inherited Alzheimer Network (DIAN) study including 120 preclinical mutation carriers (MCs) and 110 asymptomatic non-carriers (NCs). Differences in BMI and their relation with cerebral amyloid load and episodic memory as a function of estimated years to symptom onset (EYO) were analyzed...
April 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28434860/direct-brain-stimulation-modulates-encoding-states-and-memory-performance-in-humans
#7
Youssef Ezzyat, James E Kragel, John F Burke, Deborah F Levy, Anastasia Lyalenko, Paul Wanda, Logan O'Sullivan, Katherine B Hurley, Stanislav Busygin, Isaac Pedisich, Michael R Sperling, Gregory A Worrell, Michal T Kucewicz, Kathryn A Davis, Timothy H Lucas, Cory S Inman, Bradley C Lega, Barbara C Jobst, Sameer A Sheth, Kareem Zaghloul, Michael J Jutras, Joel M Stein, Sandhitsu R Das, Richard Gorniak, Daniel S Rizzuto, Michael J Kahana
People often forget information because they fail to effectively encode it. Here, we test the hypothesis that targeted electrical stimulation can modulate neural encoding states and subsequent memory outcomes. Using recordings from neurosurgical epilepsy patients with intracranially implanted electrodes, we trained multivariate classifiers to discriminate spectral activity during learning that predicted remembering from forgetting, then decoded neural activity in later sessions in which we applied stimulation during learning...
May 8, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28426125/cerclage-use-a-review-of-3-national-guidelines
#8
Jeffrey D Sperling, Joshua D Dahlke, Juan M Gonzalez
Importance: Preterm birth is a major contributor to perinatal morbidity and mortality. The most common intervention performed to improve perinatal outcomes for a woman experiencing cervical dilation in the second trimester without signs or symptoms of preterm labor is the cerclage. Objective: We sought to review and compare available national guidelines on cerclage use. Evidence Acquisition: We performed a descriptive review of 3 national guidelines on cerclage: The American Congress of Obstetricians and Gynecologists Practice Bulletin on "Cerclage for the Management of Cervical Insufficiency," Green-top Guideline from the Royal College of Obstetricians and Gynaecologists entitled "Cervical Cerclage," and the Society of Obstetricians and Gynaecologists of Canada Clinical Practice Bulletin entitled "Cervical Insufficiency and Cervical Cerclage...
April 2017: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/28410856/regional-18f-fluorodeoxyglucose-hypometabolism-is-associated-with-higher-apathy-scores-over-time-in-early-alzheimer-disease
#9
Jennifer R Gatchel, Nancy J Donovan, Joseph J Locascio, J Alex Becker, Dorene M Rentz, Reisa A Sperling, Keith A Johnson, Gad A Marshall
OBJECTIVES: Apathy is among the earliest and most pervasive neuropsychiatric symptoms in prodromal and mild Alzheimer disease (AD) dementia that correlates with functional impairment and disease progression. We investigated the association of apathy with regional 18F-fluorodeoxyglucose (FDG) metabolism in cognitively normal, mild cognitive impairment, and AD dementia subjects from the Alzheimer's Disease Neuroimaging Initiative database. DESIGN: Cross-sectional and longitudinal studies...
January 4, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28391896/lipoprotein-x-disease-in-the-setting-of-severe-cholestatic-hepatobiliary-autoimmune-disease
#10
Robert E Heinl, Heather M Tennant, John C Ricketts, Claire R Rice, Cordelia B Robinson, Pratik B Sandesara, Patrick M Moriarty, Laurence Sperling
Severe cholestatic disease and hyperlipidemia are both commonly encountered by medical professionals. This article reviews the current pathophysiological model of lipoprotein-X syndrome related to 3 cases from 2 academic medical centers in the United States.
January 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28390910/genome-wide-snps-resolve-phylogenetic-relationships-in-the-north-american-spruce-budworm-choristoneura-fumiferana-species-complex
#11
J R Dupuis, B M T Brunet, H M Bird, L M Lumley, G Fagua, B Boyle, R Levesque, M Cusson, J A Powell, F A H Sperling
High throughput sequencing technologies have revolutionized the potential to reconcile incongruence between gene and species trees, and numerous approaches have been developed to take advantage of these advances. Genotyping-by-sequencing is becoming a regular tool for gathering phylogenetic data, yet comprehensive evaluations of phylogenetic methods using these data are sparse. Here we use multiple phylogenetic and population genetic methods for genotyping-by-sequencing data to assess species relationships in a group of forest insect pests, the spruce budworm (Choristoneura fumiferana) species complex...
April 5, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28381517/hippocampal-hypometabolism-in-older-adults-with-memory-complaints-and-increased-amyloid-burden
#12
Patrizia Vannini, Bernard Hanseeuw, Catherine E Munro, Rebecca E Amariglio, Gad A Marshall, Dorene M Rentz, Alvaro Pascual-Leone, Keith A Johnson, Reisa A Sperling
OBJECTIVE: To identify the functional and pathologic correlates underlying subjective memory complaints (SMCs) in cognitively normal older adults. METHODS: Two hundred fifty-one older adults underwent resting-state fluorodeoxyglucose (FDG)-PET and Pittsburg compound B-PET β-amyloid (Aβ) imaging and filled out a questionnaire regarding SMCs. Participants were classified into 2 groups based on their Aβ burden. Age-adjusted voxel-wise correlations were used to examine SMCs, amyloid status (Aβ(+) vs Aβ(-)), and the interaction between SMCs and Aβ status as predictors of metabolism...
May 2, 2017: Neurology
https://www.readbyqxmd.com/read/28377210/similar-patterns-of-neural-activity-predict-memory-function-during-encoding-and-retrieval
#13
James E Kragel, Youssef Ezzyat, Michael R Sperling, Richard Gorniak, Gregory A Worrell, Brent M Berry, Cory Inman, Jui-Jui Lin, Kathryn A Davis, Sandhitsu R Das, Joel M Stein, Barbara C Jobst, Kareem A Zaghloul, Sameer A Sheth, Daniel S Rizzuto, Michael J Kahana
Neural networks that span the medial temporal lobe (MTL), prefrontal cortex, and posterior cortical regions are essential to episodic memory function in humans. Encoding and retrieval are supported by the engagement of both distinct neural pathways across the cortex and common structures within the medial temporal lobes. However, the degree to which memory performance can be determined by neural processing that is common to encoding and retrieval remains to be determined. To identify neural signatures of successful memory function, we administered a delayed free-recall task to 187 neurosurgical patients implanted with subdural or intraparenchymal depth electrodes...
April 2, 2017: NeuroImage
https://www.readbyqxmd.com/read/28376456/strategies-to-prioritize-clinical-options-in-primary-care
#14
EDITORIAL
Patrick J O'Connor, JoAnn M Sperl-Hillen, Karen L Margolis, Thomas E Kottke
No abstract text is available yet for this article.
January 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/28361219/shoulder-arthroplasty-for-locked-anterior-shoulder-dislocation-a-role-for-the-reversed-design
#15
Joseph M Statz, Bradley S Schoch, Joaquin Sanchez-Sotelo, John W Sperling, Robert H Cofield
INTRODUCTION: Locked anterior shoulder dislocation (LASD) is an uncommon condition associated with bone, articular cartilage, and soft tissue damage. In selected cases, shoulder arthroplasty (SA) may be the best treatment. The purpose of this study was to assess outcomes of SA for LASD. MATERIALS AND METHODS: Between 1976 and 2013, 19 SAs [three hemiarthroplasties (HA), seven total shoulder arthroplasties (TSA), and nine reverse shoulder arthroplasties (RSA), mean age 62 years] were performed for LASD...
March 30, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28359695/use-of-a-shorter-humeral-stem-in-revision-reverse-shoulder-arthroplasty
#16
Eric R Wagner, Joseph M Statz, Matthew T Houdek, Robert H Cofield, Joaquin Sánchez-Sotelo, John W Sperling
BACKGROUND: The purpose of this study was to examine the outcomes of revision reverse arthroplasty using short bone-preserving humeral components in revising a long-stemmed component. METHODS: During a 7-year period, 39 patients who underwent revision reverse shoulder arthroplasty using the long to short humeral component technique were included. The mean age was 72 years. Prior implants used in the primary setting included anatomic (n = 26), hemiarthroplasty (n = 11), and reverse (n = 2)...
March 27, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28345255/lichenoid-folliculitis-a-unifying-concept
#17
Mamina M Turegano, Leonard C Sperling
Skin diseases presenting with keratotic papules, atrophy, cicatricial alopecia and/or "lichenoid" histopathologic changes have been described under at least 30 names. This family of diseases contains 2 subgroups, largely based on clinical features: keratosis pilaris atrophicans (KPA; including keratosis pilaris atrophicans faciei/ulerythema ophryogenes, atrophoderma vermiculata, and keratosis follicularis spinulosa decalvans); and the lichen planopilaris (LPP) subgroup (including LPP, frontal fibrosing alopecia, Graham-Little-Piccardi-Lassueur Syndrome and fibrosing alopecia in a pattern distribution)...
March 26, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28343962/contextually-mediated-spontaneous-retrieval-is-specific-to-the-hippocampus
#18
Nicole M Long, Michael R Sperling, Gregory A Worrell, Kathryn A Davis, Robert E Gross, Bradley C Lega, Barbara C Jobst, Sameer A Sheth, Kareem Zaghloul, Joel M Stein, Michael J Kahana
Although it is now well established that the hippocampus supports memory encoding [1, 2], little is known about hippocampal activity during spontaneous memory retrieval. Recent intracranial electroencephalographic (iEEG) work has shown that hippocampal activity during encoding predicts subsequent temporal organization of memories [3], supporting a role in contextual binding. It is an open question, however, whether the hippocampus similarly supports contextually mediated processes during retrieval. Here, we analyzed iEEG recordings obtained from 215 epilepsy patients as they performed a free recall task...
April 3, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28335018/dissecting-gamma-frequency-activity-during-human-memory-processing
#19
Michal T Kucewicz, Brent M Berry, Vaclav Kremen, Benjamin H Brinkmann, Michael R Sperling, Barbara C Jobst, Robert E Gross, Bradley Lega, Sameer A Sheth, Joel M Stein, Sandthitsu R Das, Richard Gorniak, S Matthew Stead, Daniel S Rizzuto, Michael J Kahana, Gregory A Worrell
Gamma frequency activity (30-150 Hz) is induced in cognitive tasks and is thought to reflect underlying neural processes. Gamma frequency activity can be recorded directly from the human brain using intracranial electrodes implanted in patients undergoing treatment for drug-resistant epilepsy. Previous studies have independently explored narrowband oscillations in the local field potential and broadband power increases. It is not clear, however, which processes contribute to human brain gamma frequency activity, or their dynamics and roles during memory processing...
March 13, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28283594/cued-memory-decline-in-biomarker-defined-preclinical-alzheimer-disease
#20
Kathryn V Papp, Dorene M Rentz, Elizabeth C Mormino, Aaron P Schultz, Rebecca E Amariglio, Yakeel Quiroz, Keith A Johnson, Reisa A Sperling
OBJECTIVE: To determine whether a decline in cued recall is observable in the preclinical stage of Alzheimer disease (AD) in clinically normal older adults with elevated β-amyloid (Aβ) burden on PET imaging. METHODS: Clinically normal older adults underwent baseline neuroimaging (PET to assess Aβ(+/-) status and MRI) and annual neuropsychological testing. Cox proportional hazards models were used to assess the relative risk of cued memory decline (drop of 1, 2, 3, or 4 points on the total score of the Free and Cued Selective Reminding Test) in relation to neuroimaging measures, functional status, age, sex, and education...
April 11, 2017: Neurology
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