keyword
MENU ▼
Read by QxMD icon Read
search

Sperling M

keyword
https://www.readbyqxmd.com/read/29614677/18f-flortaucipir-binding-in-choroid-plexus-related-to-race-and-hippocampus-signal
#1
Christopher M Lee, Heidi I L Jacobs, Marta Marquié, John A Becker, Nicolas V Andrea, David S Jin, Aaron P Schultz, Matthew P Frosch, Teresa Gómez-Isla, Reisa A Sperling, Keith A Johnson
BACKGROUND: On target 18F-Flortaucipir (FTP) binding of Alzheimer's disease tau aggregates and off-target binding of melanocytes have been demonstrated with autoradiography. OBJECTIVE: We aimed to investigate the hypothesis that if binding in choroid plexus (CP) is due to melanocytes, the signal would be elevated in Black/African American (B/AA) compared to White (W) participants. In addition, we examined whether CP signal affects measurements in adjacent regions, and whether correcting for spill-in effects has an influence on associations between hippocampus (HC) FTP and amyloid or cognition...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29604050/common-data-elements-for-epilepsy-mobile-health-systems
#2
Daniel M Goldenholz, Robert Moss, David A Jost, Nathan E Crone, Gregory Krauss, Rosalind Picard, Chiara Caborni, Jose E Cavazos, John Hixson, Tobias Loddenkemper, Tracy Dixon Salazar, Laura Lubbers, Lauren C Harte-Hargrove, Vicky Whittemore, Jonas Duun-Henriksen, Eric Dolan, Nitish Kasturia, Mark Oberemk, Mark J Cook, Mark Lehmkuhle, Michael R Sperling, Patricia O Shafer
OBJECTIVE: Common data elements (CDEs) are currently unavailable for mobile health (mHealth) in epilepsy devices and related applications. As a result, despite expansive growth of new digital services for people with epilepsy, information collected is often not interoperable or directly comparable. We aim to correct this problem through development of industry-wide standards for mHealth epilepsy data. METHODS: Using a group of stakeholders from industry, academia, and patient advocacy organizations, we offer a consensus statement for the elements that may facilitate communication among different systems...
March 31, 2018: Epilepsia
https://www.readbyqxmd.com/read/29580269/comparison-of-an-injectable-toltrazuril-gleptoferron-forceris%C3%A2-and-an-oral-toltrazuril-baycox%C3%A2-injectable-iron-dextran-for-the-control-of-experimentally-induced-piglet-cystoisosporosis
#3
Anja Joachim, Aruna Shrestha, Barbara Freudenschuss, Nicola Palmieri, Barbara Hinney, Hamadi Karembe, Daniel Sperling
BACKGROUND: Cystoisospora suis causes diarrhoeal disease and reduced weight gain in suckling piglets, and a toltrazuril-based oral suspension is available for treatment. Recently a combinatorial product with toltrazuril plus iron has been developed for parenteral application. In this study we compared the efficacy of the injectable product with the oral suspension against experimentally induced piglet cystoisosporosis. METHODS: In a randomised controlled study, three groups of piglets (n = 10-13) were treated either with a fixed dose of 45 mg toltrazuril + 200 mg gleptoferron i...
March 27, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29576219/bi-allelic-mutations-in-the-mitochondrial-ribosomal-protein-mrps2-cause-sensorineural-hearing-loss-hypoglycemia-and-multiple-oxphos-complex-deficiencies
#4
Thatjana Gardeitchik, Miski Mohamed, Benedetta Ruzzenente, Daniela Karall, Sergio Guerrero-Castillo, Daisy Dalloyaux, Mariël van den Brand, Sanne van Kraaij, Ellyze van Asbeck, Zahra Assouline, Marlene Rio, Pascale de Lonlay, Sabine Scholl-Buergi, David F G J Wolthuis, Alexander Hoischen, Richard J Rodenburg, Wolfgang Sperl, Zsolt Urban, Ulrich Brandt, Johannes A Mayr, Sunnie Wong, Arjan P M de Brouwer, Leo Nijtmans, Arnold Munnich, Agnès Rötig, Ron A Wevers, Metodi D Metodiev, Eva Morava
Biogenesis of the mitochondrial oxidative phosphorylation system, which produces the bulk of ATP for almost all eukaryotic cells, depends on the translation of 13 mtDNA-encoded polypeptides by mitochondria-specific ribosomes in the mitochondrial matrix. These mitoribosomes are dual-origin ribonucleoprotein complexes, which contain mtDNA-encoded rRNAs and tRNAs and ∼80 nucleus-encoded proteins. An increasing number of gene mutations that impair mitoribosomal function and result in multiple OXPHOS deficiencies are being linked to human mitochondrial diseases...
April 5, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29552690/outcomes-of-shoulder-arthroplasty-in-diabetic-patients-as-assessed-by-peri-operative-a1c
#5
Joseph M Statz, Eric R Wagner, John W Sperling, Robert H Cofield
PURPOSE: Although diabetes mellitus (DM) has an adverse effect on complication rates in orthopaedic surgery, neither the effect of DM nor the association between haemoglobin A1C (HbA1C) and outcomes after shoulder arthroplasty (SA) has been studied. METHODS: A retrospective review of 406 SAs (70 HAs, 188 total shoulder arthroplasties [TSAs], 148 reverse total shoulder arthroplasties [RSAs]) with HbA1Cs within 90 days of surgery was conducted. The average age was 70 years (range 27-97) and 55% were female...
March 18, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29522363/mri-to-investigate-iliac-artery-wall-thickness-in-triathletes
#6
Susanne Regus, Veronika Almási-Sperling, Rolf Janka, Ulrich Rother, Michael Lell, Alexander Meyer, Werner Lang
OBJECTIVES: Endofibrosis was first described in endurance athletes. This rare disease is characterized by intimal hyperplasia of iliac arteries. Due to non-specific symptoms diagnosing could be very challenging and delayed. This represents a serious problem not only for affected athletes but also for consulting physicians. The aim of this study was to analyze intimal thickness of iliac arteries using non-contrast magnetic resonance imaging (MRI) in competitive triathletes suffering from exercise induced leg pain consistent with symptoms caused by endofibrosis...
March 9, 2018: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/29522171/preferential-degradation-of-cognitive-networks-differentiates-alzheimer-s-disease-from-ageing
#7
Jasmeer P Chhatwal, Aaron P Schultz, Keith A Johnson, Trey Hedden, Sehily Jaimes, Tammie L S Benzinger, Clifford Jack, Beau M Ances, John M Ringman, Daniel S Marcus, Bernardino Ghetti, Martin R Farlow, Adrian Danek, Johannes Levin, Igor Yakushev, Christoph Laske, Robert A Koeppe, Douglas R Galasko, Chengjie Xiong, Colin L Masters, Peter R Schofield, Kirsi M Kinnunen, Stephen Salloway, Ralph N Martins, Eric McDade, Nigel J Cairns, Virginia D Buckles, John C Morris, Randall Bateman, Reisa A Sperling
Converging evidence from structural, metabolic and functional connectivity MRI suggests that neurodegenerative diseases, such as Alzheimer's disease, target specific neural networks. However, age-related network changes commonly co-occur with neuropathological cascades, limiting efforts to disentangle disease-specific alterations in network function from those associated with normal ageing. Here we elucidate the differential effects of ageing and Alzheimer's disease pathology through simultaneous analyses of two functional connectivity MRI datasets: (i) young participants harbouring highly-penetrant mutations leading to autosomal-dominant Alzheimer's disease from the Dominantly Inherited Alzheimer's Network (DIAN), an Alzheimer's disease cohort in which age-related comorbidities are minimal and likelihood of progression along an Alzheimer's disease trajectory is extremely high; and (ii) young and elderly participants from the Harvard Aging Brain Study, a cohort in which imaging biomarkers of amyloid burden and neurodegeneration can be used to disambiguate ageing alone from preclinical Alzheimer's disease...
March 7, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29488707/the-hephiv-2017-conference-in-malta-joining-forces-for-the-earlier-diagnosis-of-hiv-and-viral-hepatitis
#8
REVIEW
D Raben, M Hoekstra, I Sperle, A J Amato Gauci, C Gauci, B West, A Sullivan, J V Lazarus, T Platteau, J K Rockstroh
OBJECTIVES: The objective of the article is to provide an overview of the results of the HepHIV 2017 Conference organized by the HIV in Europe initiative under the Maltese EU Presidency in January 2017. METHODS: A thourough review of all conference presentations (oral and poster presentations) was performed to retrieve the key outcomes of the conference. RESULTS: The key result from the conference was a call to action summarising key priorities in HIV and viral hepatitis testing and linkage to care...
February 2018: HIV Medicine
https://www.readbyqxmd.com/read/29481264/incomplete-detection-of-nonclassical-phase-space-distributions
#9
M Bohmann, J Tiedau, T Bartley, J Sperling, C Silberhorn, W Vogel
We implement the direct sampling of negative phase-space functions via unbalanced homodyne measurement using click-counting detectors. The negativities significantly certify nonclassical light in the high-loss regime using a small number of detectors which cannot resolve individual photons. We apply our method to heralded single-photon states and experimentally demonstrate the most significant certification of nonclassicality for only two detection bins. By contrast, the frequently applied Wigner function fails to directly indicate such quantum characteristics for the quantum efficiencies present in our setup without applying additional reconstruction algorithms...
February 9, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29475874/diastolic-blood-pressure-and-adverse-outcomes-in-the-topcat-treatment-of-preserved-cardiac-function-heart-failure-with-an-aldosterone-antagonist-trial
#10
Pratik B Sandesara, Wesley T O'Neal, Heval M Kelli, Matthew Topel, Ayman Samman-Tahhan, Laurence S Sperling
BACKGROUND: Although diastolic blood pressure (DBP) is independently associated with an increased risk of adverse cardiovascular outcomes in the general population, it is unclear if a similar relationship exists in patients with heart failure with preserved ejection fraction. METHODS AND RESULTS: This analysis included 1703 (mean age, 72±10 years; 50% men; 78% white) patients with heart failure with preserved ejection fraction enrolled in the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist) Trial from the Americas who were treated for hypertension...
February 23, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29467150/high-sensitivity-troponin-i-levels-and-coronary-artery-disease-severity-progression-and-long-term-outcomes
#11
Ayman Samman Tahhan, Pratik Sandesara, Salim S Hayek, Muhammad Hammadah, Ayman Alkhoder, Heval M Kelli, Matthew Topel, Wesley T O'Neal, Nima Ghasemzadeh, Yi-An Ko, Mohamad Mazen Gafeer, Naser Abdelhadi, Fahad Choudhary, Keyur Patel, Agim Beshiri, Gillian Murtagh, Jonathan Kim, Peter Wilson, Leslee Shaw, Viola Vaccarino, Stephen E Epstein, Laurence Sperling, Arshed A Quyyumi
BACKGROUND: The associations between high-sensitivity troponin I (hsTnI) levels and coronary artery disease (CAD) severity and progression remain unclear. We investigated whether there is an association between hsTnI and angiographic severity and progression of CAD and whether the predictive value of hsTnI level for incident cardiovascular outcomes is independent of CAD severity. METHODS AND RESULTS: In 3087 patients (aged 63±12 years, 64% men) undergoing cardiac catheterization without evidence of acute myocardial infarction, the severity of CAD was calculated by the number of major coronary arteries with ≥50% stenosis and the Gensini score...
February 21, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29467145/electrophysiological-signatures-of-spatial-boundaries-in-the-human-subiculum
#12
Sang Ah Lee, Jonathan F Miller, Andrew J Watrous, Michael R Sperling, Ashwini Sharan, Gregory A Worrell, Brent M Berry, Joshua P Aronson, Kathryn A Davis, Robert E Gross, Bradley Lega, Sameer Sheth, Sandhitsu R Das, Joel M Stein, Richard Gorniak, Daniel S Rizzuto, Joshua Jacobs
Environmental boundaries play a crucial role in spatial navigation and memory across a wide range of distantly-related species. In rodents, boundary representations have been identified at the single-cell level in the subiculum and entorhinal cortex of the hippocampal formation. While studies of hippocampal function and spatial behavior suggest that similar representations might exist in humans, boundary-related neural activity has not been identified electrophysiologically in humans until now. To address this gap in the literature, we analyzed intracranial recordings from the hippocampal formation of surgical epilepsy patients (of both sexes) while they performed a virtual spatial navigation task and compared the power in three frequency bands (1-4 Hz, 4-10 Hz, 30-90 Hz) for target locations near and far from the environmental boundaries...
February 21, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29435558/association-between-amyloid-and-tau-accumulation-in-young-adults-with-autosomal-dominant-alzheimer-disease
#13
Yakeel T Quiroz, Reisa A Sperling, Daniel J Norton, Ana Baena, Joseph F Arboleda-Velasquez, Danielle Cosio, Aaron Schultz, Molly Lapoint, Edmarie Guzman-Velez, John B Miller, Leo A Kim, Kewei Chen, Pierre N Tariot, Francisco Lopera, Eric M Reiman, Keith A Johnson
Importance: It is critically important to improve our ability to diagnose and track Alzheimer disease (AD) as early as possible. Individuals with autosomal dominant forms of AD can provide clues as to which and when biological changes are reliably present prior to the onset of clinical symptoms. Objective: To characterize the associations between amyloid and tau deposits in the brains of cognitively unimpaired and impaired carriers of presenilin 1 (PSEN1) E280A mutation...
February 12, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29411124/malignancy-and-chemotherapy-induced-haemophagocytic-lymphohistiocytosis-in-children-and-adolescents-a-single-centre-experience-of-20%C3%A2-years
#14
Volker Strenger, Gerald Merth, Herwig Lackner, Stephan W Aberle, Harald H Kessler, Markus G Seidel, Wolfgang Schwinger, Daniela Sperl, Petra Sovinz, Anna Karastaneva, Martin Benesch, Christian Urban
Haemophagocytic lymphohistiocytosis (HLH) is a possibly life-threatening syndrome of immune dysregulation and can be divided into primary (hereditary) and secondary forms (including malignancy-associated HLH (M-HLH)). We retrospectively analysed epidemiological, clinical, virological and laboratory data from patients with M-HLH treated at our department between 1995 and 2014. Out of 1.706 haemato-/oncologic patients treated at our department between 1995 and 2014, we identified 22 (1.29%) patients with secondary HLH (1...
February 6, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29410414/closed-loop-stimulation-of-temporal-cortex-rescues-functional-networks-and-improves-memory
#15
Youssef Ezzyat, Paul A Wanda, Deborah F Levy, Allison Kadel, Ada Aka, Isaac Pedisich, Michael R Sperling, Ashwini D Sharan, Bradley C Lega, Alexis Burks, Robert E Gross, Cory S Inman, Barbara C Jobst, Mark A Gorenstein, Kathryn A Davis, Gregory A Worrell, Michal T Kucewicz, Joel M Stein, Richard Gorniak, Sandhitsu R Das, Daniel S Rizzuto, Michael J Kahana
Memory failures are frustrating and often the result of ineffective encoding. One approach to improving memory outcomes is through direct modulation of brain activity with electrical stimulation. Previous efforts, however, have reported inconsistent effects when using open-loop stimulation and often target the hippocampus and medial temporal lobes. Here we use a closed-loop system to monitor and decode neural activity from direct brain recordings in humans. We apply targeted stimulation to lateral temporal cortex and report that this stimulation rescues periods of poor memory encoding...
February 6, 2018: Nature Communications
https://www.readbyqxmd.com/read/29407307/acute-liver-failure-due-to-amanita-phalloides-poisoning-therapeutic-approach-and-outcome
#16
E Kieslichova, S Frankova, M Protus, D Merta, E Uchytilova, J Fronek, J Sperl
INTRODUCTION: Amanita phalloides poisoning is a potentially fatal cause of acute liver failure. The aim of this study was to analyze the impact of initial patients' characteristics and different treatment modalities on the outcome of patients with liver failure caused by Amanita poisoning. MATERIAL AND METHODS: We retrospectively evaluated 23 patients admitted to our center between July 2007 and August 2016. RESULTS: Mean time interval between Amanita phalloides ingestion and the onset of gastrointestinal symptoms was 12...
January 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29404403/electrical-stimulation-modulates-high-%C3%AE-activity-and-human-memory-performance
#17
Michal T Kucewicz, Brent M Berry, Vaclav Kremen, Laura R Miller, Fatemeh Khadjevand, Youssef Ezzyat, Joel M Stein, Paul Wanda, Michael R Sperling, Richard Gorniak, Kathryn A Davis, Barbara C Jobst, Robert E Gross, Bradley Lega, S Matt Stead, Daniel S Rizzuto, Michael J Kahana, Gregory A Worrell
Direct electrical stimulation of the brain has emerged as a powerful treatment for multiple neurological diseases, and as a potential technique to enhance human cognition. Despite its application in a range of brain disorders, it remains unclear how stimulation of discrete brain areas affects memory performance and the underlying electrophysiological activities. Here, we investigated the effect of direct electrical stimulation in four brain regions known to support declarative memory: hippocampus (HP), parahippocampal region (PH) neocortex, prefrontal cortex (PF), and lateral temporal cortex (TC)...
January 2018: ENeuro
https://www.readbyqxmd.com/read/29403032/structural-tract-alterations-predict-downstream-tau-accumulation-in-amyloid-positive-older-individuals
#18
Heidi I L Jacobs, Trey Hedden, Aaron P Schultz, Jorge Sepulcre, Rodrigo D Perea, Rebecca E Amariglio, Kathryn V Papp, Dorene M Rentz, Reisa A Sperling, Keith A Johnson
Animal models of Alzheimer's disease have suggested that tau pathology propagation, facilitated by amyloid pathology, may occur along connected pathways. To investigate these ideas in humans, we combined amyloid scans with longitudinal data on white matter connectivity, hippocampal volume, tau positron emission tomography and memory performance in 256 cognitively healthy older individuals. Lower baseline hippocampal volume was associated with increased mean diffusivity of the connecting hippocampal cingulum bundle (HCB)...
February 5, 2018: Nature Neuroscience
https://www.readbyqxmd.com/read/29389750/18f-florbetapir-positron-emission-tomography-determined-cerebral-%C3%AE-amyloid-deposition-and-neurocognitive-performance-after-cardiac-surgery
#19
Rebecca Y Klinger, Olga G James, Salvador Borges-Neto, Tiffany Bisanar, Yi-Ju Li, Wenjing Qi, Miles Berger, Niccolò Terrando, Mark F Newman, P Murali Doraiswamy, Joseph P Mathew
BACKGROUND: Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patients manifesting cognitive dysfunction at 6 weeks postoperatively. METHODS: Amyloid deposition was evaluated in cardiac surgical patients at 6 weeks (n = 40) and 1 yr (n = 12); neurocognitive function was assessed at baseline (n = 40), 6 weeks (n = 37), 1 yr (n = 13), and 3 yr (n = 9)...
April 2018: Anesthesiology
https://www.readbyqxmd.com/read/29378247/convergent-herbivory-on-conifers-by-choristoneura-moths-after-boreal-forest-formation
#20
Giovanny Fagua, Fabien L Condamine, Bryan M T Brunet, Anne-Laure Clamens, Jérôme Laroche, Roger C Levesque, Michel Cusson, Felix A H Sperling
Mitogenomes are useful markers for phylogenetic studies across a range of taxonomic levels. Here, we focus on mitogenome variation across the tortricid moth genus Choristoneura and particularly the spruce budworm (Choristoneura fumiferana) species complex, a notorious pest group of North American conifer forests. Phylogenetic relationships of Tortricidae, representing two subfamilies, four tribes and nine genera, were analyzed using 21 mitogenomes. These included six newly-sequenced mitogenomes for species in the spruce budworm complex plus three additional Choristoneura species and 12 previously published mitogenomes from other tortricids and one from the Cossidae...
January 26, 2018: Molecular Phylogenetics and Evolution
keyword
keyword
60601
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"