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https://www.readbyqxmd.com/read/28060054/patient-reported-and-objectively-measured-function-before-and-after-reverse-shoulder-arthroplasty
#1
Wendy J Hurd, Melissa M Morrow, Emily J Miller, Robert A Adams, John W Sperling, Kenton R Kaufman
BACKGROUND AND PURPOSE: Documenting functional outcomes after reverse shoulder arthroplasty (RSA) is critical to advancing patient care. The interplay been self-reported and objectively measured outcome measures has not been widely described. The utilization of wearable devices to document upper extremity limb activity is a new approach for objectively measuring outcomes. Therefore, the purpose of this study was to evaluate changes in pain, and self-reported function and objectively measured limb activity after RSA...
January 5, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/28054081/imaging-metals-in-caenorhabditis-elegans
#2
REVIEW
M Aschner, C Palinski, M Sperling, U Karst, T Schwerdtle, J Bornhorst
Systemic trafficking and storage of essential metal ions play fundamental roles in living organisms by serving as essential cofactors in various cellular processes. Thereby metal quantification and localization are critical steps in understanding metal homeostasis, and how their dyshomeostasis might contribute to disease etiology and the ensuing pathologies. Furthermore, the amount and distribution of metals in organisms can provide insight into their underlying mechanisms of toxicity and toxicokinetics. While in vivo studies on metal imaging in mammalian experimental animals are complex, time- and resource-consuming, the nematode Caenorhabditis elegans (C...
January 5, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28007989/cad-mutations-and-uridine-responsive-epileptic-encephalopathy
#3
Johannes Koch, Johannes A Mayr, Bader Alhaddad, Christian Rauscher, Jörgen Bierau, Reka Kovacs-Nagy, Karlien L M Coene, Ingrid Bader, Monika Holzhacker, Holger Prokisch, Hanka Venselaar, Ron A Wevers, Felix Distelmaier, Tilman Polster, Steffen Leiz, Cornelia Betzler, Tim M Strom, Wolfgang Sperl, Thomas Meitinger, Saskia B Wortmann, Tobias B Haack
Unexplained global developmental delay and epilepsy in childhood pose a major socioeconomic burden. Progress in defining the molecular bases does not often translate into effective treatment. Notable exceptions include certain inborn errors of metabolism amenable to dietary intervention. CAD encodes a multifunctional enzyme involved in de novo pyrimidine biosynthesis. Alternatively, pyrimidines can be recycled from uridine. Exome sequencing in three families identified biallelic CAD mutations in four children with global developmental delay, epileptic encephalopathy, and anaemia with anisopoikilocytosis...
December 21, 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/27992822/thrombolytic-treatment-to-stroke-mimic-patients-via-telestroke
#4
Ganesh Asaithambi, Amy L Castle, Michael A Sperl, Jayashree Ravichandran, Aditi Gupta, Bridget M Ho, Sandra K Hanson
OBJECTIVE: The safety and outcomes of intravenous thrombolysis (IVT) to stroke patients via telestroke (TS) is similar to those presenting to stroke centers. Little is known on the accuracy of TS diagnosis among those receiving IVT. We sought to compare the rate of patients receiving IVT with diagnosis of ischemic stroke as opposed to stroke mimic (SM) in our TS network to those who presented to our comprehensive stroke center (CSC). MATERIALS AND METHODS: Consecutive patients receiving IVT between August 2014 and June 2015 were identified at our CSC and TS network...
December 14, 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27989841/cardiorespiratory-fitness-is-differentially-associated-with-cortical-thickness-in-young-and-older-adults
#5
Victoria Williams, Jasmeet P Hayes, Daniel E Forman, David H Salat, Reisa A Sperling, Mieke Verfaellie, Scott M Hayes
Aging is associated with reductions in gray matter volume and cortical thickness. One factor that may play a role in mitigating age-associated brain decline is cardiorespiratory fitness (CRF). Although previous work has identified a positive association between CRF and gray matter volume, the relationship between CRF and cortical thickness, which serves as a more sensitive indicator of gray matter integrity, has yet to be assessed in healthy young and older adults. To address this gap in the literature, 32 young and 29 older adults completed treadmill-based progressive maximal exercise testing to assess CRF (peak VO2), and structural magnetic resonance imaging (MRI) to determine vertex-wise surface-based cortical thickness metrics...
October 27, 2016: NeuroImage
https://www.readbyqxmd.com/read/27981905/natural-approaches-in-diabetes-management-a-review-of-diet-exercise-and-natural-products
#6
William M Schultz, Tina Varghese, Robert E Hein, Devinder S Dhindsa, Elliot N Mahlof, Hannah C Cai, Geoffrey Southmayd, Pratik B Sandesaraa, Danny J Eapen, Laurence S Sperling
Diabetes mellitus (DM) is a highly prevalent condition that causes significant morbidity and mortality in the United States and worldwide. Conventional therapies include lifestyle modification, oral pharmacological agents, and subcutaneous insulin. Emerging data suggest that natural approaches to the treatment of DM may help supplement current therapies for further glycemic control. Herein, we review the evidence of several natural modalities for DM treatment. We describe the pathophysiology of diabetes and its complications, provide an overview of current pharmacologic treatments, and finally, discuss natural approaches to diabetes management...
December 16, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27935031/interictal-epileptiform-discharges-impair-word-recall-in-multiple-brain-areas
#7
Peter C Horak, Stephen Meisenhelter, Yinchen Song, Markus E Testorf, Michael J Kahana, Weston D Viles, Krzysztof A Bujarski, Andrew C Connolly, Ashlee A Robbins, Michael R Sperling, Ashwini D Sharan, Gregory A Worrell, Laura R Miller, Robert E Gross, Kathryn A Davis, David W Roberts, Bradley Lega, Sameer A Sheth, Kareem A Zaghloul, Joel M Stein, Sandhitsu R Das, Daniel S Rizzuto, Barbara C Jobst
OBJECTIVES: Interictal epileptiform discharges (IEDs) have been linked to memory impairment, but the spatial and temporal dynamics of this relationship remain elusive. In the present study, we aim to systematically characterize the brain areas and times at which IEDs affect memory. METHODS: Eighty epilepsy patients participated in a delayed free recall task while undergoing intracranial electroencephalography (EEG) monitoring. We analyzed the locations and timing of IEDs relative to the behavioral data in order to measure their effects on memory...
December 9, 2016: Epilepsia
https://www.readbyqxmd.com/read/27933058/skewed-lung-ccr4-to-ccr6-cd4-t-cell-ratio-in-idiopathic-pulmonary-fibrosis-is-associated-with-pulmonary-function
#8
Ayodeji Adegunsoye, Cara L Hrusch, Catherine A Bonham, Mohammad R Jaffery, Kelly M Blaine, Meghan Sullivan, Matthew M Churpek, Mary E Strek, Imre Noth, Anne I Sperling
RATIONALE: Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal lung disease. While it has been suggested that T cells may contribute to IPF pathogenesis, these studies have focused primarily on T cells outside of the pulmonary interstitium. Thus, the role of T cells in the diseased lung tissue remains unclear. OBJECTIVE: To identify whether specific CD4(+) T cell subsets are differentially represented in lung tissue from patients with IPF. METHODS: CD4(+) T cell subsets were measured in lung tissue obtained from patients with IPF at the time of lung transplantation, and from age- and gender-matched organ donors with no known lung disease...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27901041/bainbridge-ropers-syndrome-caused-by-loss-of-function-variants-in-asxl3-a-recognizable-condition
#9
Alma Kuechler, Johanna Christina Czeschik, Elisabeth Graf, Ute Grasshoff, Ulrike Hüffmeier, Tiffany Busa, Stefanie Beck-Woedl, Laurence Faivre, Jean-Baptiste Rivière, Ingrid Bader, Johannes Koch, André Reis, Ute Hehr, Olaf Rittinger, Wolfgang Sperl, Tobias B Haack, Thomas Wieland, Hartmut Engels, Holger Prokisch, Tim M Strom, Hermann-Josef Lüdecke, Dagmar Wieczorek
Truncating ASXL3 mutations were first identified in 2013 by Bainbridge et al. as a cause of syndromic intellectual disability in four children with similar phenotypes using whole-exome sequencing. The clinical features - postulated by Bainbridge et al. to be overlapping with Bohring-Opitz syndrome - were developmental delay, severe feeding difficulties, failure to thrive and neurological abnormalities. This condition was included in OMIM as 'Bainbridge-Ropers syndrome' (BRPS, #615485). To date, a total of nine individuals with BRPS have been published in the literature in four reports (Bainbridge et al...
November 30, 2016: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/27825022/implementation-of-subjective-cognitive-decline-criteria-in-research-studies
#10
José L Molinuevo, Laura A Rabin, Rebecca Amariglio, Rachel Buckley, Bruno Dubois, Kathryn A Ellis, Michael Ewers, Harald Hampel, Stefan Klöppel, Lorena Rami, Barry Reisberg, Andrew J Saykin, Sietske Sikkes, Colette M Smart, Beth E Snitz, Reisa Sperling, Wiesje M van der Flier, Michael Wagner, Frank Jessen
INTRODUCTION: Subjective cognitive decline (SCD) manifesting before clinical impairment could serve as a target population for early intervention trials in Alzheimer's disease (AD). A working group, the Subjective Cognitive Decline Initiative (SCD-I), published SCD research criteria in the context of preclinical AD. To successfully apply them, a number of issues regarding assessment and implementation of SCD needed to be addressed. METHODS: Members of the SCD-I met to identify and agree on topics relevant to SCD criteria operationalization in research settings...
November 5, 2016: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/27806159/association-of-higher-cortical-amyloid-burden-with-loneliness-in-cognitively-normal-older-adults
#11
Nancy J Donovan, Olivia I Okereke, Patrizia Vannini, Rebecca E Amariglio, Dorene M Rentz, Gad A Marshall, Keith A Johnson, Reisa A Sperling
Importance: Emotional and behavioral symptoms in cognitively normal older people may be direct manifestations of Alzheimer disease (AD) pathophysiology at the preclinical stage, prior to the onset of mild cognitive impairment. Loneliness is a perceived state of social and emotional isolation that has been associated with cognitive and functional decline and an increased risk of incident AD dementia. We hypothesized that loneliness might occur in association with elevated cortical amyloid burden, an in vivo research biomarker of AD...
December 1, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27798509/multicenter-study-of-temporal-trends-in-the-achievement-of-atherosclerotic-cardiovascular-disease-risk-factor-goals-during-cardiac-rehabilitation
#12
Neil F Gordon, Richard D Salmon, Laurence S Sperling, Brenda S Wright, George C Faircloth, Terri L Gordon, Martin R Berk, Melvyn Rubenfire, Barry A Franklin
PURPOSE: Secondary prevention risk factor goals have been established by the American Heart Association/American College of Cardiology, and the American Heart Association has further delineated ideal cardiovascular health metrics. We evaluated risk factor goal achievement during early-outpatient cardiac rehabilitation (CR) and temporal trends in risk factor control. METHODS: Patients completed assessments on entry into and exit from CR at 35 centers between 2000 and 2009 and were categorized into 3 cohorts: entire (N = 12 984), 2000-2004 (n = 5468), and 2005-2009 (n = 7516) cohorts...
January 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/27796416/-intraoperative-multidimensional-visualization
#13
J Sperling, A Kauffels, M Grade, F Alves, P Kühn, B M Ghadimi
Modern intraoperative techniques of visualization are increasingly being applied in general and visceral surgery. The combination of diverse techniques provides the possibility of multidimensional intraoperative visualization of specific anatomical structures. Thus, it is possible to differentiate between normal tissue and tumor tissue and therefore exactly define tumor margins. The aim of intraoperative visualization of tissue that is to be resected and tissue that should be spared is to lead to a rational balance between oncological and functional results...
December 2016: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/27751558/research-priorities-to-reduce-the-global-burden-of-dementia-by-2025
#14
REVIEW
Hiral Shah, Emiliano Albanese, Cynthia Duggan, Igor Rudan, Kenneth M Langa, Maria C Carrillo, Kit Yee Chan, Yves Joanette, Martin Prince, Martin Rossor, Shekhar Saxena, Heather M Snyder, Reisa Sperling, Mathew Varghese, Huali Wang, Marc Wortmann, Tarun Dua
At the First WHO Ministerial Conference on Global Action Against Dementia in March, 2015, 160 delegates, including representatives from 80 WHO Member States and four UN agencies, agreed on a call for action to reduce the global burden of dementia by fostering a collective effort to advance research. To drive this effort, we completed a globally representative research prioritisation exercise using an adapted version of the Child Health and Nutrition Research Initiative method. We elicited 863 research questions from 201 participants and consolidated these questions into 59 thematic research avenues, which were scored anonymously by 162 researchers and stakeholders from 39 countries according to five criteria...
November 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27738998/cognitive-resilience-in-clinical-and-preclinical-alzheimer-s-disease-the-association-of-amyloid-and-tau-burden-on-cognitive-performance
#15
Dorene M Rentz, Elizabeth C Mormino, Kathryn V Papp, Rebecca A Betensky, Reisa A Sperling, Keith A Johnson
We explored the cross-sectional relationships between β-amyloid (Aβ) and inferior temporal tau deposition (IFT Tau) on cognitive performance and whether cognitive reserve (CR) modifies these associations. We studied 156 participants classified into groups of clinically normal (CN = 133), mild cognitive impairment (MCI = 17) and Alzheimer disease (AD = 6) dementia. AMNART IQ served as a proxy of CR and cognitive performance was assessed using the MMSE. In separate linear regression models predicting MMSE, we examined the interactions of CR x global Aβ and CR x IFT tau across all participants and within the CN group alone...
October 13, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27724996/the-influence-of-demographic-factors-on-subjective-cognitive-concerns-and-beta-amyloid
#16
Sarah L Aghjayan, Rachel F Buckley, Patrizia Vannini, Dorene M Rentz, Jonathan D Jackson, Reisa A Sperling, Keith A Johnson, Rebecca E Amariglio
BACKGROUND: Converging evidence suggests that subjective cognitive concerns (SCC) are associated with biomarker evidence of Alzheimer's disease (AD) prior to objective clinical impairment. However, the sensitivity of SCC reports in early AD may be biased by demographic factors. Here, we sought to investigate whether age, education, and sex influence the relationship between SCC and amyloid (Aβ) burden. METHODS: In this cross-sectional study, we examined 252 clinically normal (CN) individuals (57...
October 11, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27720142/patient-characteristics-associated-with-greater-blood-pressure-control-in-a-randomized-trial-of-home-blood-pressure-telemonitoring-and-pharmacist-management
#17
Stephen E Asche, Patrick J O'Connor, Steven P Dehmer, Beverly B Green, Anna R Bergdall, Michael V Maciosek, Rachel A Nyboer, Pamala A Pawloski, JoAnn M Sperl-Hillen, Nicole K Trower, Karen L Margolis
This paper reports subgroup analysis of a successful cluster-randomized trial to identify attributes of hypertensive patients who benefited more or less from an intervention combining blood pressure (BP) telemonitoring and pharmacist management. The end point was BP < 140/90 mm Hg at 6-month follow-up. Fourteen baseline patient characteristics were selected a priori as subgroup variables. Among the 351 trial participants, 44% were female, 84% non-Hispanic white, mean age was 60.9 years, and mean BP was 149/86 mm Hg...
November 2016: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/27716863/severe-vitamin-d-deficiency-in-human-immunodeficiency-virus-infected-pregnant-women-is-associated-with-preterm-birth
#18
Jennifer Jao, Laura Freimanis, Marisa M Mussi-Pinhata, Rachel A Cohen, Jacqueline Pontes Monteiro, Maria Leticia Cruz, Andrea Branch, Rhoda S Sperling, George K Siberry
Background Low maternal vitamin D has been associated with preterm birth (PTB). Human immunodeficiency virus (HIV)-infected pregnant women are at risk for PTB, but data on maternal vitamin D and PTB in this population are scarce. Methods In a cohort of Latin American HIV-infected pregnant women from the National Institute of Child Health and Human Development International Site Development Initiative protocol, we examined the association between maternal vitamin D status and PTB. Vitamin D status was defined as the following 25-hydroxyvitamin D levels: severe deficiency (< 10 ng/mL), deficiency (10-20 ng/mL), insufficiency (21-29 ng/mL), and sufficiency (≥30 ng/mL)...
October 7, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27692115/comprehensive-cardiovascular-risk-reduction-and-cardiac-rehabilitation-in-diabetes-and-the-metabolic-syndrome
#19
REVIEW
Robert E Heinl, Devinder S Dhindsa, Elliot N Mahlof, William M Schultz, Johnathan C Ricketts, Tina Varghese, Amirhossein Esmaeeli, Marc P Allard-Ratick, Anthony J Millard, Heval M Kelli, Pratik B Sandesara, Danny J Eapen, Laurence Sperling
The epidemic of obesity has contributed to a growing burden of metabolic syndrome (MetS) and diabetes mellitus (DM) worldwide. MetS is defined as central obesity along with associated factors such as hypertriglyceridemia, low high-density lipoprotein cholesterol, hyperglycemia, and hypertension. MetS and DM are associated with significant cardiovascular morbidity and mortality. Healthy behavioural modification is the cornerstone for reducing the atherosclerotic cardiovascular disease burden in this population...
October 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/27649320/correction-quantitative-amyloid-imaging-in-autosomal-dominant-alzheimer-s-disease-results-from-the-dian-study-group
#20
Yi Su, Tyler M Blazey, Christopher J Owen, Jon J Christensen, Karl Friedrichsen, Nelly Joseph-Mathurin, Qing Wang, Russ C Hornbeck, Beau M Ances, Abraham Z Snyder, Lisa A Cash, Robert A Koeppe, William E Klunk, Douglas Galasko, Adam M Brickman, Eric McDade, John M Ringman, Paul M Thompson, Andrew J Saykin, Bernardino Ghetti, Reisa A Sperling, Keith A Johnson, Stephen P Salloway, Peter R Schofield, Colin L Masters, Victor L Villemagne, Nick C Fox, Stefan Förster, Kewei Chen, Eric M Reiman, Chengjie Xiong, Daniel S Marcus, Michael W Weiner, John C Morris, Randall J Bateman, Tammie L S Benzinger
[This corrects the article DOI: 10.1371/journal.pone.0152082.].
2016: PloS One
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