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https://www.readbyqxmd.com/read/28227673/colorimetric-determinations-of-lithium-levels-in-drop-volumes-of-human-plasma-for-monitoring-patients-with-bipolar-mood-disorder
#1
M Qassem, M Hickey, P A Kyriacou, M Qassem, M Hickey, P A Kyriacou, M Qassem, M Hickey, P A Kyriacou
Lithium preparations are considered the most reliable form of mood stabilizing medication for patients with Bipolar disorder. Nevertheless, lithium is a toxic element and its therapeutic range is extremely narrow, with levels of 0.61.0 mEq considered normal, whereas levels above 1.5 mEq are toxic. Thus unfortunately, many patients reach toxic levels that lead to unnecessary complications. It is believed that personal monitoring of blood lithium levels would benefit patients taking lithium medication. Therefore, our aim is to develop a personal lithium blood level analyzer for patients with bipolar mood disorder, and we report here our initial results of a colorimetric-based method used to test drop-volumes of human plasma that had been spiked with lithium...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227351/video-based-depression-detection-using-local-curvelet-binary-patterns-in-pairwise-orthogonal-planes
#2
Anastasia Pampouchidou, Kostas Marias, Manolis Tsiknakis, Panagiotis Simos, Fan Yang, Guillaume Lemaitre, Fabrice Meriaudeau, Anastasia Pampouchidou, Kostas Marias, Manolis Tsiknakis, Panagiotis Simos, Fan Yang, Guillaume Lemaitre, Fabrice Meriaudeau, Fabrice Meriaudeau, Guillaume Lemaitre, Manolis Tsiknakis, Kostas Marias, Anastasia Pampouchidou, Panagiotis Simos, Fan Yang
Depression is an increasingly prevalent mood disorder. This is the reason why the field of computer-based depression assessment has been gaining the attention of the research community during the past couple of years. The present work proposes two algorithms for depression detection, one Frame-based and the second Video-based, both employing Curvelet transform and Local Binary Patterns. The main advantage of these methods is that they have significantly lower computational requirements, as the extracted features are of very low dimensionality...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226853/generalized-binary-noise-stimulation-enables-time-efficient-identification-of-input-output-brain-network-dynamics
#3
Yuxiao Yang, Maryam M Shanechi, Yuxiao Yang, Maryam M Shanechi, Yuxiao Yang, Maryam M Shanechi
Identification of input-output (IO) dynamics of brain networks in response to electrical stimulation is essential for devising closed-loop therapies for neurological disorders such as major depression. A critical component for accurate IO identification is the stimulation input design. The time available for open-loop stimulation to perform system identification is typically limited. While our prior design of a binary noise (BN) modulated input pattern satisfies the requirements for optimal identification and clinical safety, it does not incorporate any prior information about the underlying network...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28222537/timing-and-kinetics-of-nonmotor-fluctuations-in-advanced-parkinson-s-disease
#4
Christiana Ossig, Daniel Sippel, Mareike Fauser, Florin Gandor, Wolfgang H Jost, Georg Ebersbach, Alexander Storch
BACKGROUND: Nonmotor symptoms (NMS) are known to fluctuate together with motor oscillations in advanced PD, but their timing and kinetics remains enigmatic. OBJECTIVE: To evaluate timing and kinetics of NMS fluctuations. METHODS: Analysis of diary data from 17 fluctuating PD patients. Diaries were completed by rating NMS as absent (defined herein as NMS On state) or present (NMS Off state) and motor function for every hour for 5 consecutive days...
February 8, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28222508/chronic-lithium-treatment-in-a-rat-model-of-basal-forebrain-cholinergic-depletion-effects-on-memory-impairment-and-neurodegeneration
#5
Francesca Gelfo, Debora Cutuli, Annalisa Nobili, Paola De Bartolo, Marcello D'Amelio, Laura Petrosini, Carlo Caltagirone
Alzheimer's disease (AD) is an age-related neurodegenerative disorder with multifactorial etiopathogenesis, characterized by progressive loss of memory and other cognitive functions. A fundamental neuropathological feature of AD is the early and severe brain cholinergic neurodegeneration. Lithium is a monovalent cation classically utilized in the treatment of mood disorders, but recent evidence also advances a beneficial potentiality of this compound in neurodegeneration. Interestingly, lithium acts on several processes whose alterations characterize the brain cholinergic impairment at short and long term...
February 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28219749/behavioral-phenotypes-associated-with-mptp-induction-of-partial-lesions-in-common-marmosets-callithrix-jacchus
#6
Kimberley A Phillips, Corinna N Ross, Jennifer Spross, Catherine J Cheng, Alyssa Izquierdo, K C Biju, Cang Chen, Senlin Li, Suzette D Tardif
Parkinson's disease is a chronic neurodegenerative disorder with the core motor features of resting tremor, bradykinesia, rigidity, and postural instability. Non-motor symptoms also occur, and include cognitive dysfunction, mood disorders, anosmia (loss of smell), and REM sleep disturbances. As the development of medications and other therapies for treatment of non-motor symptoms is ongoing, it is essential to have animal models that aid in understanding the neural changes underlying non-motor PD symptoms and serve as a testing ground for potential therapeutics...
February 17, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28218465/compliance-with-national-guidelines-on-isotretinoin-where-are-we-2-years-since-the-last-audit-results-of-the-national-isotretinoin-re-audit-2014
#7
L S Exton, S T Cheung, A G Brain, M F Mohd Mustapa, D A R de Berker
BACKGROUND: In 2010, the British Association of Dermatologists (BAD) published clinical guidelines for the safe introduction and continued use of isotretinoin in patients with acne in the UK. The BAD provides UK dermatologists with a facility for national audit, and it undertook an audit on compliance with these guidelines in 2012. AIM: To determine current clinical practices relating to use of isotretinoin among dermatologists in the UK (including geographical variations) as measured against BAD standards, and to ascertain any improvement since the 2012 audit...
February 20, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28218343/immediate-affective-responses-of-gait-training-in-neurological-rehabilitation-a-randomized-crossover-trial
#8
Martin Niedermeier, Larissa Ledochowski, Andreas Mayr, Leopold Saltuari, Martin Kopp
OBJECTIVE: To examine the immediate effects of physical therapy and robotic-assisted gait training on affective responses of gait training in neurological rehabilitation. DESIGN: Randomized crossover trial with blinded observers. PATIENTS: Sixteen patients with neurological disorders (stroke, traumatic brain injury, spinal cord injury, multiple sclerosis). METHODS: All patients underwent 2 single treatment sessions: physical therapy and robotic-assisted gait training...
February 16, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28216087/neural-consequences-of-post-exertion-malaise-in-myalgic-encephalomyelitis-chronic-fatigue-syndrome
#9
Dane B Cook, Alan R Light, Kathleen C Light, Gordon Broderick, Morgan R Shields, Ryan J Dougherty, Jacob D Meyer, Stephanie VanRiper, Aaron J Stegner, Laura D Ellingson, Suzanne D Vernon
Post exertion malaise is one of the most debilitating aspects of Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome, yet the neurobiological consequences are largely unexplored. The objective of the study was to determine the neural consequences of acute exercise using functional brain imaging. Fifteen female Myalgic Encephalomyelitis/Chronic Fatigue Syndrome patients and 15 healthy female controls completed 30 minutes of submaximal exercise (70% of peak heart rate) on a cycle ergometer. Symptom assessments (e...
February 16, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28213121/determination-of-a-clinically-important-difference-and-definition-of-a-responder-threshold-for-the-ucsd-performance-based-skills-assessment-upsa-in-patients-with-major-depressive-disorder
#10
Philip D Harvey, William Jacobson, Wei Zhong, George G Nomikos, Christina Kurre Olsen, Elizabeth Merikle, Michael Cronquist Christensen
BACKGROUND: This article reports an evaluation of the psychometric properties and clinically important difference (CID) threshold of the UCSD Performance-Based Skills Assessment (UPSA) in major depressive disorder (MDD), using data from a large-scale study of the effects of vortioxetine on cognitive functioning and functional capacity in MDD patients. METHODS: Adults with moderate-to-severe recurrent MDD and self-reported cognitive dysfunction were randomized to 8 weeks of double-blind treatment with vortioxetine 10/20mg QD (flexible), duloxetine 60mg QD, or placebo...
February 14, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28205135/apium-graveolens-extract-influences-mood-and-cognition-in-healthy-mice
#11
Phetcharat Boonruamkaew, Wanida Sukketsiri, Pharkphoom Panichayupakaranant, Wijittra Kaewnam, Supita Tanasawet, Varomyalin Tipmanee, Pilaiwanwadee Hutamekalin, Pennapa Chonpathompikunlert
Apium graveolens is a food flavoring which possesses various health promoting effects. This study investigates the effect of a sub-acute administration of A. graveolens on cognition and anti-depression behaviors via antioxidant and related neurotransmitter systems in mice brains. Cognition and depression was assessed by various models of behavior. The antioxidant system of glutathione peroxidase (GPx), % inhibition of superoxide anion (O2(-)), and lipid peroxidation were studied. In addition, neurochemical parameters including acetylcholinesterase (AChE) and monoamine oxidase-type A (MAO-A) were also evaluated...
February 15, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28203140/tamoxifen-activation-of-cre-recombinase-has-no-persisting-effects-on-adult-neurogenesis-or-learning-and-anxiety
#12
Peter Rotheneichner, Pasquale Romanelli, Lara Bieler, Sebastian Pagitsch, Pia Zaunmair, Christina Kreutzer, Richard König, Julia Marschallinger, Ludwig Aigner, Sébastien Couillard-Després
Adult neurogenesis is a tightly regulated process continuously taking place in the central nervous system of most mammalian species. In neuroscience research, transgenic animals bearing the tamoxifen-inducible CreER(T2)-Lox system are widely used. In this study, we made use of a Nestin-CreER(T2)/R26R-YFP transgenic mouse model in which the CreER(T2) activates the expression of YFP in multipotent neural stem cells upon tamoxifen application. Humoral factors, such as the levels of estrogens, have been reported to affect the hippocampal neurogenesis...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28192175/increased-anxiety-like-phenotype-in-female-guinea-pigs-following-reduced-neurosteroid-exposure-in-utero
#13
Angela L Cumberland, Hannah K Palliser, Gabrielle K Crombie, David W Walker, Jonathan J Hirst
Neurosteroids are essential for aiding proper fetal neurodevelopment. Pregnancy compromises such as preterm birth, prenatal stress and intrauterine growth restriction are associated with an increased risk of developing behavioural and mood disorders, particularly during adolescence. These pathologies involve the premature loss or alteration of trophic steroid hormones reaching the fetus leading to impaired neurodevelopment. While the specific programming mechanisms are yet to be fully elucidated, in adult life, dysfunctions of allopregnanolone action are prevalent in individuals with depression, post-traumatic stress disorder and anxiety disorders...
February 9, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28191365/thinking-and-feeling-individual-differences-in-habitual-emotion-regulation-and-stress-related-mood-are-associated-with-prefrontal-executive-control
#14
Matthew A Scult, Annchen R Knodt, Johnna R Swartz, Bartholomew D Brigidi, Ahmad R Hariri
Calculating math problems from memory may seem unrelated to everyday processing of emotions, but they have more in common than one might think. Prior research highlights the importance of the dorsolateral prefrontal cortex (dlPFC) in executive control, intentional emotion regulation, and experience of dysfunctional mood and anxiety. While it has been hypothesized that emotion regulation may be related to 'cold' (ie. not emotion-related) executive control, this assertion has not been tested. We address this gap by providing evidence that greater dlPFC activity during 'cold' executive control is associated with increased use of cognitive reappraisal to regulate emotions in everyday life...
2017: Clinical Psychological Science
https://www.readbyqxmd.com/read/28189942/functional-impairment-and-cognitive-performance-in-mood-disorders-a-community-sample-of-young-adults
#15
Amanda N Reyes, Taiane A Cardoso, Karen Jansen, Thaíse C Mondin, Luciano D M Souza, Pedro V S Magalhães, Flavio Kapczinski, Ricardo A Silva
The aim of this study was to compare the global functioning and cognitive performance in a community sample of young adults with mood disorders versus community controls. This was a cross-sectional study nested in a cohort study with a community sample. Data was collected from February 2012 to June 2014; specifically, at a mean of five years after the first phase, all young adults were invited to participate in a re-evaluation. Mini International Neuropsychiatric Interview - PLUS (MINI-PLUS) was used for the diagnosis of mood disorders...
January 24, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28189925/impact-of-alcohol-use-motives-and-internalizing-symptoms-on-mood-changes-in-response-to-drinking-an-ecological-momentary-assessment-investigation
#16
Stephanie M Gorka, Donald Hedeker, Thomas M Piasecki, Robin Mermelstein
BACKGROUND: Theory implies that individuals who use alcohol to cope with negative emotions experience the acute mood-altering effects they desire. However, no study to date has directly tested whether alcohol coping motives map onto alcohol-induced changes in mood in real-time or how co-occurring internalizing symptoms (i.e., depression and anxiety) impact the relation between coping motives and alcohol-induced changes in mood. METHOD: The current study tested the unique and interactive effects of alcohol coping motives and internalizing symptoms on mood changes during drinking using ecological momentary assessment (EMA) in a sample of young adults (n=257)...
January 28, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28189098/telmisartan-attenuates-diabetes-induced-depression-in-rats
#17
Urmila Aswar, Shilpa Chepurwar, Sumit Shintre, Manoj Aswar
BACKGROUND: Role of brain renin angiotensin system (RAS) is well understood and various clinical studies have proposed neuroprotective effects of ARB's. It is also assumed that diabetic depression is associated with activation of brain RAS, HPA axis dysregulation and brain inflammatory events. Therefore, the present study was designed to investigate the antidepressant effect of low dose telmisartan (TMS) in diabetes induced depression (DID) in rats. METHODS: Diabetes was induced by injecting streptozotocin...
December 9, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28185899/lurasidone-versus-treatment-as-usual-for-cognitive-impairment-in-euthymic-patients-with-bipolar-i-disorder-a-randomised-open-label-pilot-study
#18
Lakshmi N Yatham, Sylvia Mackala, Jayasree Basivireddy, Sharon Ahn, Nazlin Walji, Chen Hu, Raymond W Lam, Ivan J Torres
BACKGROUND: Cognitive impairment is present in euthymic patients with bipolar disorder and correlates with impairments in everyday functioning. We aimed to examine the efficacy of lurasidone adjunctive therapy compared with treatment as usual (TAU) in improving cognition. METHODS: For this randomised, open-label, pilot study, we recruited patients aged 19-65 years with euthymic bipolar I disorder from the Mood Disorder Centre in UBC Hospital (Vancouver, Canada)...
February 6, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28182138/construct-validity-of-the-depression-and-somatic-symptoms-scale-evaluation-by-mokken-scale-analysis
#19
Ya-Hsin Chou, Chin-Pang Lee, Chia-Yih Liu, Ching-I Hung
OBJECTIVE: Previous studies of the Depression and Somatic Symptoms Scale (DSSS), a free scale, have been based on the classical test theory, and the construct validity and dimensionality of the DSSS are as yet uncertain. The aim of this study was to use Mokken scale analysis (MSA) to assess the dimensionality of the DSSS. METHODS: A sample of 214 psychiatric outpatients with mood and anxiety disorders were enrolled at a medical center in Taiwan (age: mean [SD] =38...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28171810/short-versus-long-small-sided-game-training-during-ramadan-in-soccer-players
#20
Hana Baklouti, Noureddine Rejeb, Asma Aloui, Hamdi Jaafar, Achraf Ammar, Hamdi Chtourou, Olivier Girard, Nizar Souissi
OBJECTIVE: To compare the effects of two small-sided game (SSG) training formats (4 × 4 min (SSG-S) and 2 × 8 min (SSG-L)) conducted during Ramadan on Hoff and five-jump (5JT) tests' performances and session rating of perceived exertion (sRPE). DESIGN: Three group, case-control. SETTING: Field tests. PARTICIPANTS: Twenty-four male soccer players were divided into 3 groups: 2 groups undertaking 4 weeks of SSG-S (n = 8) or SSG-L (n = 8) during Ramadan and a control group (n = 8)...
October 24, 2016: Physical Therapy in Sport
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