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https://www.readbyqxmd.com/read/30246167/maternal-cerebrospinal-fluid-glutamate-in-response-to-variable-foraging-demand-relationship-to-cerebrospinal-fluid-serotonin-metabolites-in-grown-offspring
#1
Jeremy D Coplan, Nishant K Gupta, Sarah K Flynn, Wade J Reiner, David Gaita, Sasha L Fulton, Anna V Rozenboym, Jean E Tang, Thomas B Cooper, J John Mann
Background: Maternal response to allostatic overload during infant rearing may alter neurobiological measures in grown offspring, potentially increasing susceptibility to mood and anxiety disorders. We examined maternal cerebrospinal fluid (CSF) glutamate response during exposure to variable foraging demand (VFD), a bonnet macaque model of allostatic overload, testing whether activation relative to baseline predicted concomitant CSF elevations of the stress neuropeptide, corticotropin-releasing factor...
January 2018: Chronic Stress
https://www.readbyqxmd.com/read/30244920/lentiviral-mediated-let-7d-microrna-overexpression-induced-anxiolytic-and-anti-depressant-like-behaviors-and-impaired-dopamine-d3-receptor-expression
#2
Amine Bahi, Jean-Luc Dreyer
Generalized anxiety and major depression disorders (MDD) are severe debilitating mood disorders whose etiology are not fully understood, but growing evidence indicates that microRNAs (miRNAs) might play a key role in their neuropathophysiological mechanisms. In the current study, we investigate the role of Lethal-7 (let-7d) miRNA, and its direct target dopamine D3 receptor (D3R) gain-of-function, in the hippocampus, in preclinical models of anxiety and depression in mice. For this purpose, we have constructed a lentiviral vector carrying let-7d miRNA and its anxiolytic effect was investigated by employing the open-field (OF) and the elevated plus maze (EPM) tests...
September 20, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30244217/protocol-for-the-insight-study-a-randomised-controlled-trial-of-single-dose-tocilizumab-in-patients-with-depression-and-low-grade-inflammation
#3
Golam M Khandaker, Bianca P Oltean, Muzaffer Kaser, Claire R M Dibben, Rajini Ramana, Deepak R Jadon, Robert Dantzer, Alasdair J Coles, Glyn Lewis, Peter B Jones
INTRODUCTION: Observational studies indicate a potentially causal role for interleukin 6 (IL-6), a proinflammatory cytokine, in pathogenesis of depression, but interventional studies based on patients with depression have not been conducted. Tocilizumab, anti-inflammatory drug, is a humanised monoclonal antibody that inhibits IL-6 signalling and is licensed in the UK for treatment of rheumatoid arthritis. The main objectives of this study are to test whether IL-6 contributes to the pathogenesis of depression and to examine potential mechanisms by which IL-6 affects mood and cognition...
September 21, 2018: BMJ Open
https://www.readbyqxmd.com/read/30244099/cognitive-function-and-quality-of-life-in-vorinostat-treated-patients-following-matched-unrelated-donor-myeloablative-conditioning-hematopoietic-cell-transplant
#4
Flora Hoodin, Leah LaLonde, Josh Errickson, Kristen Votruba, Rachel Kentor, Erin Gatza, Pavan Reddy, Sung Won Choi
Myeloablative conditioning allogeneic hematopoietic cell transplantation (HCT) puts patients at greater risk for significant cognitive and quality of life decline compared with recipients of reduced intensity conditioning or autologous HCT. Vorinostat, an HDAC inhibitor, has been shown to have neuroprotective and neurorestorative effects in preclinical models of neurological diseases. Thus, within the context of a myeloablative conditioning phase II clinical trial of vorinostat combined with tacrolimus and methotrexate for GVHD prophylaxis, we conducted an ancillary study to evaluate feasibility of assessing associations between Vorinostat and neurocognitive function and quality of life (ClinicalTrials...
September 19, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/30243986/early-intrathecal-infusion-of-everolimus-restores-cognitive-function-and-mood-in-a-murine-model-of-alzheimer-s-disease
#5
Tommaso Cassano, Alessandro Magini, Stefano Giovagnoli, Alice Polchi, Silvio Calcagnini, Lorenzo Pace, Michele Angelo Lavecchia, Caterina Scuderi, Maria Rosanna Bronzuoli, Loredana Ruggeri, Maria Pia Gentileschi, Adele Romano, Silvana Gaetani, Federico De Marco, Carla Emiliani, Diego Dolcetta
The discovery that mammalian target of rapamycin (mTOR) inhibition increases lifespan in mice and restores/delays many aging phenotypes has led to the identification of a novel potential therapeutic target for the treatment of Alzheimer's disease (AD). Among mTOR inhibitors, everolimus, which has been developed to improve the pharmacokinetic characteristics of rapamycin, has been extensively profiled in preclinical and clinical studies as anticancer and immunosuppressive agent, but no information is available about its potential effects on neurodegenerative disorders...
September 19, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/30241979/the-impact-of-follow-up-visits-and-diaries-on-patient-outcome-after-discharge-from-intensive-care-a-descriptive-and-explorative-study
#6
Eva Åkerman, Ann Langius-Eklöf
OBJECTIVES: To explore the possible effects of intensive care follow-up visits and diaries on patients physical and psychosocial problems at 2, 6, and 12 months after unit discharge as well as the patient' experiences of follow-up visits and diaries. METHODS: A descriptive and explorative cohort design. Patients (n = 441) with a length of ICU stay for ≥24 hours, who responded to the 3-set 4P questionnaire were included. Patients were divided into groups depending on when they responded to the questionnaire and if had or had not a follow-up visit or a diary...
September 18, 2018: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/30241453/do-powered-over-ground-lower-limb-robotic-exoskeletons-affect-outcomes-in-the-rehabilitation-of-people-with-acquired-brain-injury
#7
Nicola Postol, Jodie Marquez, Stephanie Spartalis, Andrew Bivard, Neil James Spratt
PURPOSE: To assess the effects of lower limb robotic exoskeletons on outcomes in the rehabilitation of people with acquired brain injury. MATERIALS AND METHODS: A systematic review of seven electronic databases was conducted. The primary outcome of interest was neuromuscular function. Secondary outcomes included quality of life, mood, acceptability and safety. Studies were assessed for methodological quality and recommendations were made using the GRADE system. RESULTS: Of 2469 identified studies, 13 (n = 322) were included in the review...
September 21, 2018: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/30240533/education-and-the-balance-between-dynamic-and-stationary-functional-connectivity-jointly-support-executive-functions-in-relapsing-remitting-multiple-sclerosis
#8
Sue-Jin Lin, Irene Vavasour, Brenda Kosaka, David K B Li, Anthony Traboulsee, Alex MacKay, Martin J McKeown
Graphical network characteristics and nonstationary functional connectivity features, both derived from resting-state functional magnetic resonance imaging (rsfMRI) data, have been associated with cognitive performance in healthy subjects. How these features jointly relate to cognition in diseased states has not been investigated. In this study, 46 relapsing-remitting multiple sclerosis subjects underwent rsfMRI scans and a focused cognitive battery. With a sliding window approach, we examined six dynamic network features that indicated how connectivity changed over time as well as six measures derived from graph theory to reflect static network characteristics...
September 21, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/30239762/making-sense-of-rodent-models-of-anhedonia
#9
Simona Scheggi, Maria Graziella De Montis, Carla Gambarana
A markedly reduced interest or pleasure in activities previously considered pleasurable is a main symptom in mood disorder and psychosis, and is often present in other psychiatric disorders and neurodegenerative diseases. This condition can be labeled as "anhedonia", although in its most rigorous connotation the term refers to the lost capacity to feel pleasure that is one aspect of the complex phenomenon of processing and responding to reward. The responses to rewarding stimuli are relatively easy to study in rodents, and the experimental conditions that consistently and persistently impair these responses are used to model anhedonia...
September 20, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30237691/sleep-disturbances-in-diabetic-peripheral-neuropathy-patients-a-clinical-and-polysomnographic-study
#10
Wafik Said Bahnasy, Yasser Abo Elfotoh El-Heneedy, Ehab Ahmed Shawky El-Seidy, Nema Ata Allah Labib, Ibrahim Salah Eldeen Ibrahim
Background: Disordered sleep breathing is a common complication of diabetic peripheral neuropathy (DPN) manifested by excessive daytime sleepiness, morning headache, morning dizziness, cognitive decline, and mood changes. Methods: This study was performed on 30 non-obese type 2 diabetic patients; 20 with clinically evident DPN and 10 without. Ten age-, sex-, and body mass index-matched healthy control subjects were also included. Patients and control were subjected to history taking, neurological examination, glycated hemoglobin, and clinical assessment of the sensori-motor manifestations by the neuropathy symptom score and neuropathy disability score...
2018: The Egyptian journal of neurology, psychiatry and neurosurgery
https://www.readbyqxmd.com/read/30236748/alterations-in-temporal-summation-of-pain-and-conditioned-pain-modulation-across-an-episode-of-experimental-exercise-induced-low-back-pain
#11
Megan McPhee, Thomas Graven-Nielsen
Persistent pain conditions, including low back pain (LBP), are often accompanied by alterations in pro-nociceptive and anti-nociceptive mechanisms, as quantified by Temporal Summation of Pain (TSP) and Conditioned Pain Modulation (CPM). It remains unclear whether altered pain sensitivity, CPM and/or TSP are a consequence of pain presence, or determine the degree of pain development. Pressure pain sensitivity, TSP, and CPM were assessed across an episode of exercise-induced-LBP maintained for several days. Thirty healthy individuals participated in three experimental sessions: Before (Day-0), two-days after fatiguing back muscle exercise with exercise-induced-LBP present (Day-2), and after pain resolution (Day-7)...
September 17, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/30235919/protein-kinase-c-activity-and-delayed-recovery-of-sleep-wake-cycle-in-mouse-model-of-bipolar-disorder
#12
Eunsoo Moon, Byeong-Moo Choe, Je-Min Park, Young In Chung, Byung Dae Lee, Jae-Hong Park, Young Min Lee, Hee Jeong Jeong, YongJun Cheon, Yoonmi Choi, Jeonghyun Park
OBJECTIVE: Previous studies reported the delayed recovery group after circadian rhythm disruption in mice showed higher quinpiroleinduced locomotor activity. This study aimed to compare not only Protein Kinase C (PKC) activities in frontal, striatal, hippocampus and cerebellum, but also relative PKC activity ratios among brain regions according to recovery of circadian rhythm. METHODS: The circadian rhythm disruption protocol was applied to eight-week-old twenty male Institute Cancer Research mice...
September 2018: Psychiatry Investigation
https://www.readbyqxmd.com/read/30233313/a-single-dose-of-5-meo-dmt-stimulates-cell-proliferation-neuronal-survivability-morphological-and-functional-changes-in-adult-mice-ventral-dentate-gyrus
#13
Rafael Vitor Lima da Cruz, Thiago C Moulin, Lyvia Lintzmaier Petiz, Richardson N Leão
The subgranular zone (SGZ) of dentate gyrus (DG) is one of the few regions in which neurogenesis is maintained throughout adulthood. It is believed that newborn neurons in this region encode temporal information about partially overlapping contextual memories. The 5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a naturally occurring compound capable of inducing a powerful psychedelic state. Recently, it has been suggested that DMT analogs may be used in the treatment of mood disorders. Due to the strong link between altered neurogenesis and mood disorders, we tested whether 5-MeO-DMT is capable of increasing DG cell proliferation...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/30233288/high-fat-feeding-improves-anxiety-type-behavior-induced-by-ovariectomy-in-rats
#14
Ana P S Dornellas, Valter T Boldarine, Amanda P Pedroso, Lorenza O T Carvalho, Iracema S de Andrade, Tânia M Vulcani-Freitas, Carla C C Dos Santos, Cláudia M da Penha Oller do Nascimento, Lila M Oyama, Eliane B Ribeiro
Menopause-induced changes may include increased incidence of both depression/anxiety and obesity. We hypothesized that behavioral changes that may develop after ovarian failure could be related to neurochemical and metabolic aspects affected by this condition and that high-fat intake may influence these associations. The present study investigated in rats the effects of ovariectomy, either alone or combined with high-fat diets enriched with either lard or fish-oil, on metabolic, behavioral and monoaminergic statuses, and on gene expression of neuropeptides and receptors involved in energy balance and mood regulation...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/30233264/physical-activity-and-sociodemographic-variables-related-to-global-health-quality-of-life-and-psychological-factors-in-breast-cancer-survivors
#15
Efrossini D Patsou, George T Alexias, Fotios G Anagnostopoulos, Michalis V Karamouzis
Background: Breast cancer is one of the most common cancers affecting women worldwide and depression and anxiety are disturbing side effects of cancer diagnosis and treatment. The aim of this study was to examine the associations of physical activity in global health, quality of life (QoL), and psychological factors (depressive symptoms, self-esteem, and anxiety) in breast cancer survivors after completing cancer treatment and through survivorship. Demographic variables (marital status, education, income), medical status (cancer stage), and level of physical activity (metabolic equivalent of task [MET]) were tested as predictors of depressive mood, anxiety, self-esteem, and QoL in younger and older breast cancer survivors...
2018: Psychology Research and Behavior Management
https://www.readbyqxmd.com/read/30233149/medication-adherence-in-chronic-illness-do-beliefs-about-medications-play-a-role
#16
Jacinthe Lemay, Mohammad Waheedi, Sarah Al-Sharqawi, Tania Bayoud
Background: Several medicines are prescribed for chronic disease management; however, adherence to long-term therapy remains poor. Culture influences beliefs about medications and, ultimately, adherence to treatment. There is a paucity of data with regard to beliefs about medications in the Middle East region, and it remains to be determined how these beliefs would impact treatment adherence. Objectives: To investigate the relationship between patients' beliefs about medications with self-reported adherence to treatment among a chronically ill multicultural patient population...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/30231300/neuropsychological-and-criminological-features-of-female-homicide-offenders
#17
Jaclyn M Fox, Michael Brook, Robert L Heilbronner, Teresa Susmaras, Robert E Hanlon
Few studies have examined life history and cognitive characteristics unique to female homicide offenders. Understanding these characteristics could aid in risk assessment for extreme violence in this group of offenders. The current study utilized t-tests or chi-square tests to compare 27 female and 81 male homicide offenders on psychiatric, neurologic, criminal, and cognitive characteristics. Additionally, we explored the role of abuse history in female offenders through Kruskal-Wallis or Fisher's exact tests...
September 19, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/30229855/hypothalamus-enlargement-in-mood-disorders
#18
S Schindler, L Schmidt, M Stroske, M Storch, A Anwander, R Trampel, M Strauß, U Hegerl, S Geyer, P Schönknecht
OBJECTIVE: The purpose of this study was to determine, in vivo, whether the hypothalamus volume is reduced in patients with mood disorders. METHODS: The cross-sectional study included 20 unmedicated (MDDu) and 20 medicated patients with major depressive disorder, 21 patients with bipolar disorder, and 23 controls. Twenty of the controls were matched to the MDDu. Seven Tesla, T1-weighted magnetic resonance images were acquired and processed using methods specifically developed for high-precision volumetry of the hypothalamus...
September 19, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/30227315/similar-profiles-of-cognitive-domain-deficits-between-medication-na%C3%A3-ve-patients-with-bipolar-ii-depression-and-those-with-major-depressive-disorder
#19
Tao Liu, Shuming Zhong, Bing Wang, Xiaoxiao Liao, Shunkai Lai, Yanbin Jia
BACKGROUND: Bipolar disorder (BD) II is more likely to be misdiagnosed as major depressive disorder (MDD) than other types of BD, leading to incorrect treatment and poor outcomes. Previous studies have shown inconsistent results regarding the differences in cognitive deficits between the two disorders. To eliminate the compounding effects of medication and aging, we sought to investigate changes in cognitive function in medication-naïve, non-late-life patients with BDII and MDD. METHODS: Three subject groups were enrolled: 30 depressed BDII patients, 30 depressed MDD patients and 30 healthy controls...
May 31, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/30223002/probiotics-modify-body-weight-together-with-anxiety-states-via-pro-inflammatory-factors-in-hfd-treated-syrian-golden-hamster
#20
Ennio Avolio, Gilda Fazzari, Merylin Zizza, Antonino De Lorenzo, Laura Di Renzo, Raffaella Alò, Rosa Maria Facciolo, Marcello Canonaco
Emerging studies are beginning to suggest that emotional states together with healthful measures constitute pertinent features of our lifestyle in which bad eating habits but more importantly what our gut has to host are causing great concern. It is well known that humans have established mutual relationships with a wide array of colonized microbes (collectively called gut microbiota) consisting of bacteria, fungi, eukaryotic parasites and viruses. The gut microbiota has exhibited a notable ability of communicating with the brain via a two-way system that includes the vagus nerve, immune sites, and a number of neurotransmitters...
September 14, 2018: Behavioural Brain Research
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