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https://www.readbyqxmd.com/read/29909305/the-association-of-duration-and-severity-of-disease-with-executive-function-differences-between-drug-na%C3%A3-ve-patients-with-bipolar-and-unipolar-depression
#1
Tao Yang, Guoqing Zhao, Ruizhi Mao, Jia Huang, Xianrong Xu, Yousong Su, Na Zhu, Rubai Zhou, Xiao Lin, Weiping Xia, Fan Wang, Rui Liu, Xing Wang, Zhijia Huang, Yong Wang, Yingyan Hu, Lan Cao, Chengmei Yuan, Zuowei Wang, Raymond W Lam, Jun Chen, Yiru Fang
BACKGROUND: The aims of this study were to investigate the differences in executive function and the relationship with clinical factors between drug-naïve patients with bipolar depression (BDD) and unipolar depression (UPD). METHODS: Drug-naïve patients with BDD, UPD and healthy controls (HC) were recruited (30 cases in each group). All patients were assessed with Hamilton Rating Scale for Anxiety (HAM-A), Hamilton Rating Scale for Depression-17 (HAM-D), and Young Mania Rating Scale (YMRS)...
May 29, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29909293/learning-to-actively-cope-with-stress-in-female-mice
#2
David M Lyons, Christine L Buckmaster, Alan F Schatzberg
Repeated exposure to a same-sex resident stranger enhances subsequent indications of active coping that generalize across multiple contexts in intruder male mice. Here we investigate female mice for comparable learning to cope training effects. Stress coping research focused on females is important because stress related mood and anxiety disorders are more prevalent in women than men. Female mice were monitored for coping behavior in open-field, object-exploration, and tail-suspension tests conducted after repeated exposure to a same-sex resident stranger...
June 9, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29908775/insulin-resistance-is-associated-with-depression-risk-in-polycystic-ovary-syndrome
#3
Eleni A Greenwood, Lauri A Pasch, Marcelle I Cedars, Richard S Legro, Esther Eisenberg, Heather G Huddleston
OBJECTIVE: To test the hypothesis that insulin resistance is associated with depression risk in polycystic ovary syndrome (PCOS). DESIGN: Secondary analysis of data from a multicenter randomized trial. SETTING: Multicenter university-based clinical practices. PATIENT(S): Seven hundred thirty-eight women with PCOS by modified Rotterdam criteria seeking pregnancy enrolled in a randomized clinical trial comparing clomiphene citrate versus letrozole...
June 13, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29908383/cognition-mood-and-quality-of-life-outcomes-among-low-literacy-adults-living-with-epilepsy-in-rural-kenya-a-preliminary-study
#4
Patrick N Mwangala, Symon M Kariuki, Moses K Nyongesa, Paul Mwangi, Esther Chongwo, Charles R Newton, Amina Abubakar
Epilepsy is frequently associated with neurocognitive impairments, mental health, and psychosocial problems but these are rarely documented in low- and middle-income countries. The aim of this study was to examine the neurocognitive outcomes, depressive symptoms, and psychosocial adjustments of people with epilepsy (PWE) in Kilifi, Kenya. We evaluated the impact of these outcomes on health-related quality of life. Self-report, interviewer-administered measures of depression (Major Depression Inventory) and quality of life (RAND SF-36) were administered to 63 PWE and 83 community controls...
June 12, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29905117/melanopsin-expression-in-the-cornea
#5
Anton Delwig, Shawnta Y Chaney, Andrea S Bertke, Jan Verweij, Susana Quirce, Delaine D Larsen, Cindy Yang, Ethan Buhr, Russell VAN Gelder, Juana Gallar, Todd Margolis, David R Copenhagen
A unique class of intrinsically photosensitive retinal ganglion cells in mammalian retinae has been recently discovered and characterized. These neurons can generate visual signals in the absence of inputs from rods and cones, the conventional photoreceptors in the visual system. These light sensitive ganglion cells (mRGCs) express the non-rod, non-cone photopigment melanopsin and play well documented roles in modulating pupil responses to light, photoentrainment of circadian rhythms, mood, sleep and other adaptive light functions...
January 2018: Visual Neuroscience
https://www.readbyqxmd.com/read/29900753/a-patient-centered-activity-regimen-improves-participation-in-physical-activity-interventions-in-advanced-stage-lung-cancer
#6
Brett C Bade, J Madison Hyer, Benjamin T Bevill, Alex Pastis, Alana M Rojewski, Benjamin A Toll, Gerard A Silvestri
INTRODUCTION: Physical activity (PA) is a potential therapy to improve quality of life in patients with advanced-stage lung cancer (LC), but no PA regimen has been shown to be beneficial, clinically practical, and sustainable. We sought to test the hypothesis that a patient-centered activity regimen (PCAR) will improve patient participation and PA more effectively than weekly phone calls. METHODS: In patients with advanced-stage LC, we implemented a walking-based activity regimen and motivated patients via either weekly phone calls (n = 29; FitBit Zip accelerometer) or PCAR (n = 15; FitBit Flex, an educational session, and twice-daily gain-framed text messages)...
June 1, 2018: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29898451/pathophysiology-of-depression-molecular-regulation-of-melatonin-homeostasis-current-status
#7
REVIEW
Monika Dmitrzak-Weglarz, Edyta Reszka
Circadian rhythm alterations resulting in disturbed sleep and disturbed melatonin secretion are flagship features of depression. Melatonin, known as a hormone of darkness, is secreted by the pineal gland located near to the center of the brain between the two hemispheres. Melatonin has an antidepressant effect by maintaining the body's circadian rhythm, by regulating the pattern of expression of the clock genes in the suprachiasmatic nucleus (SCN) and modifying the key genes of serotoninergic neurotransmission that are linked with a depressive mood...
June 13, 2018: Neuropsychobiology
https://www.readbyqxmd.com/read/29895009/stability-of-cellular-immune-parameters-over-12-weeks-in-patients-with-major-depression-or-somatoform-disorder-and-in-healthy-controls
#8
Daniela Krause, Theresa M Stapf, Verena B Kirnich, Anika Hennings, Sabine Riemer, Agnieszka Chrobok, Daniel R Fries, Francisco Pedrosa Gil, Winfried Rief, Markus J Schwarz, Ralf Schmidmaier
OBJECTIVE: Cellular immune status in major depression (MD) patients differs from that in somatoform disorder (SFD) patients and healthy controls (HC). It is still questionable whether the patterns of immune parameters remain stable over time. Therefore, we studied lymphocyte and monocyte cell counts and neopterin levels in peripheral blood of MD and SFD patients and HC over 12 weeks and tested for correlations between biochemical and psychometric parameters. METHODS: Thirty-nine patients with MD, 27 with SFD, and 51 HC were recruited...
June 12, 2018: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29894931/the-user-experiences-and-clinical-outcomes-of-an-online-personal-health-record-to-support-self-management-of-bipolar-disorder-a-pretest-posttest-pilot-study
#9
Silvio C G H van den Heuvel, Daniëlle Meije, Eline J Regeer, Henny Sinnema, Rixt F Riemersma, Ralph W Kupka
BACKGROUND: Self-management comprises knowledge, behavior, activities and resources providing people with bipolar disorder (BD) control over fluctuating mood and activity-patterns. The 'Self-management and Dialogue in Bipolar Disorder' project entailed the tailoring of an online personal health record (PHR) originally designed for the chronically ill to monitor condition and share information with their clinician to people with BD (PHR-BD). The aim of this study was to evaluate the feasibility, utility and user-experiences of participants with BD, relatives, and healthcare professionals who worked with the PHR-BD...
June 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29894448/neurologic-outcomes-after-extracorporeal-membrane-oxygenation-a-systematic-review
#10
Katharine Boyle, Ryan Felling, Alvin Yiu, Wejdan Battarjee, Jamie McElrath Schwartz, Cynthia Salorio, Melania M Bembea
OBJECTIVES: The goal of this systematic review of the literature was to summarize neurologic outcomes following neonatal and pediatric extracorporeal membrane oxygenation. DATA SOURCES: We conducted electronic searches of PubMed, Scopus, Web of Science, CINAHL, Cochrane, and EMBASE. STUDY SELECTION: Inclusion criteria included publication dates 2000-2016, patient ages 0-18 years, and use of standardized measures to evaluate outcomes after extracorporeal membrane oxygenation...
June 11, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29893160/lithium-effects-on-serine-threonine-kinases-activity-high-throughput-kinomic-profiling-of-lymphoblastoid-cell-lines-from-excellent-responders-and-non-responders-bipolar-patients
#11
Jeverson Moreira, Gaëlle Noe, Savithri Rangarajan, Cindie Courtin, Bruno Etain, Pierre A Geoffroy, Jean-Louis Laplanche, Michel Vidal, Frank Bellivier, Cynthia Marie-Claire
OBJECTIVES: Lithium (Li) is the leading mood stabilizer for maintenance treatment in bipolar disorder (BD). However, response to lithium is heterogeneous with more than 60% of patients experiencing partial or no response. In vitro and in vivo molecular studies have reported the implication of kinases in the pathophysiology of BD. METHODS: Since kinases are putative targets for lithium therapeutic action, we conducted the first pilot study using kinase array technology to evaluate the global serine/threonine kinases (STK) profiles in cell lines from BD I subtype patients classified as Li excellent-responders (ER) and non-responder (NR) to Li treatment...
June 12, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29892235/reduced-prefrontal-activation-during-the-tower-of-london-and-verbal-fluency-task-in-patients-with-bipolar-depression-a-multi-channel-nirs-study
#12
Linyan Fu, Dan Xiang, Jiawei Xiao, Lihua Yao, Ying Wang, Ling Xiao, Huiling Wang, Gaohua Wang, Zhongchun Liu
Background: The Tower of London (TOL) task is one of the most commonly used tests for evaluating executive functions, and can indicate planning and problem-solving abilities. The aim of this study was to evaluate hemodynamic changes between the task period and rest period in patients with bipolar depression during the TOL task and the verbal fluency task (VFT) using near-infrared spectroscopy (NIRS). Methods: Forty-three patients with bipolar depression and 32 healthy controls (HCs) matched for sex, age, handedness, and years of education were enrolled in this study...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29892141/delayed-complications-and-long-term-management-of-sulfur-mustard-poisoning-a-narrative-review-of-recent-advances-by-iranian-researchers-part-%C3%B0-%C3%B0-clinical-management-and-therapy
#13
REVIEW
Leila Etemad, Mohammad Moshiri, Mahdi Balali-Mood
The present study aimed to review and discuss the recommended and recently suggested protocols by Iranian researchers for a long-term treatment of delayed complications of sulfur mustard (DCSM) in veterans. As indicated clinically, patients who suffer from delayed ocular complications of sulfur mustard (DOCS) benefit from treatments for dry eyes, therapeutic contact lenses, amniotic membrane transplantation; blepharorrhaphy, tarsorrhaphy, limbal stem cell transplantation; corneal transplantation, topical steroids, and immunosuppressive...
May 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29891215/effect-of-electroconvulsive-therapy-on-neural-response-to-affective-pictures-a-randomized-sham-controlled-fmri-study
#14
K W Miskowiak, J Macoveanu, M B Jørgensen, C V Ott, M M Støttrup, H M Jensen, A Jørgensen, C J Harmer, O B Paulson, H R Siebner, L V Kessing
Electroconvulsive therapy (ECT) is the most effective treatment for severe depression but its neurocognitive mechanisms are unclear. This randomized, sham-controlled functional magnetic resonance imaging (fMRI) study explored the effects of a single ECT on neural response to affective pictures. Twenty-seven patients with major depressive disorder were randomized to a single active ECT (N = 15) or sham (N = 12) session in a double-blind, parallel-group design. On the following day, patients underwent fMRI during which they viewed pleasant, unpleasant and neutral pictures and performed a free recall test after the scan...
June 8, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29888314/reduced-left-ventricular-dimension-and-function-following-early-life-stress-a-thrifty-phenotype-hypothesis-engendering-risk-for-mood-and-anxiety-disorders
#15
Jeremy D Coplan, Anna V Rozenboym, Sasha L Fulton, Venkatesh Panthangi, Jean Tang, Lakshmi Thiramangalakdi, Tarique D Perera, Yang Liu, Haroon Kamran, Michael J Owens, Charles B Nemeroff, Leonard A Rosenblum, John G Kral, Louis Salciccioli, Jason Lazar
Background: Early life stress (ELS) in macaques in the form of insecure maternal attachment putatively induces epigenetic adaptations resulting in a "thrifty phenotype" throughout the life cycle. For instance, ELS induces persistent increases in insulin resistance, hippocampal and corpus callosum atrophy and reduced "behavioral plasticity", which, taken together, engenders an increased risk for mood and anxiety disorders in humans but also a putative sparing of calories...
February 2018: Neurobiology of Stress
https://www.readbyqxmd.com/read/29888305/evidence-for-altered-brain-reactivity-to-norepinephrine-in-veterans-with-a-history-of-traumatic-stress
#16
Rebecca C Hendrickson, Murray A Raskind, Steven P Millard, Carl Sikkema, Garth E Terry, Kathleen F Pagulayan, Ge Li, Elaine R Peskind
Background: Increases in the quantity or impact of noradrenergic signaling have been implicated in the pathophysiology of posttraumatic stress disorder (PTSD). This increased signaling may result from increased norepinephrine (NE) release, from altered brain responses to NE, or from a combination of both factors. Here, we tested the hypothesis that Veterans reporting a history of trauma exposure would show an increased association between brain NE and mental health symptoms commonly observed after trauma, as compared to Veterans who did not report a history of trauma exposure, consistent with the possibility of increased brain reactivity to NE after traumatic stress...
February 2018: Neurobiology of Stress
https://www.readbyqxmd.com/read/29888231/exon-array-biomarkers-for-the-differential-diagnosis-of-schizophrenia-and-bipolar-disorder
#17
Marquis Philip Vawter, Robert Philibert, Brandi Rollins, Patricia L Ruppel, Terry W Osborn
This study developed potential blood-based biomarker tests for diagnosing and differentiating schizophrenia (SZ), bipolar disorder type I (BD), and normal control (NC) subjects using mRNA gene expression signatures. A total of 90 subjects ( n = 30 each for the three groups of subjects) provided blood samples at two visits. The Affymetrix exon microarray was used to profile the expression of over 1.4 million probesets. We selected potential biomarker panels using the temporal stability of the probesets and also back-tested them at two different visits for each subject...
May 2018: Molecular Neuropsychiatry
https://www.readbyqxmd.com/read/29886201/long-term-treatment-with-supraphysiologic-doses-of-levothyroxine-in-treatment-refractory-mood-disorders-a-prospective-study-of-cardiovascular-tolerability
#18
Maximilian Pilhatsch, Anne Berghöfer, René Mayer-Pelinski, Gunnar Berghöfer, Roland Ricken, Martin Möckel, York Kühnle, Cathrin Sauer, Peter C Whybrow, Michael Bauer
BACKGROUND: To investigate long-term effects of adjunctive prophylactic treatment with supraphysiologic doses of levothyroxine (L-T4) on cardiovascular tolerability in 23 patients with treatment-refractory mood disorders. METHODS: Starting point for a comprehensive cardiovascular assessment in patients was the indication for long-term maintenance treatment with L-T4 (mean dose 463 mcg/day). Prospective longitudinal assessment of the cardiovascular risk profile included in addition to a physical examination and blood pressure measurement, several technical investigations: resting electrocardiogram, transthoracic echocardiogram, cardiac stress test, and holter electrocardiogram...
May 30, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29885591/examining-the-link-between-weight-suppression-and-non-suicidal-self-injurious-behaviors
#19
Pamela K Keel, K Jean Forney, Jennifer M Buchman-Schmitt, Grace A Kennedy, Thomas E Joiner
BACKGROUND: Given the negative consequences of excess weight, a large portion of the US population is seeking to obtain and maintain weight loss. Weight Suppression (WS) represents the difference between previous highest adult weight and current weight and may have negative psychological consequences. The current study examined the link between WS and lifetime non-suicidal self-injurious (NSSI) behavior and explored indirect effects in this link using survey data in two large samples...
June 2, 2018: Eating Behaviors
https://www.readbyqxmd.com/read/29885324/how-does-drinking-water-affect-attention-and-memory-the-effect-of-mouth-rinsing-and-mouth-drying-on-children-s-performance
#20
Caroline J Edmonds, Naomi Harte, Mark Gardner
There is general consensus that drinking water facilitates certain cognitive processes. However, it is not yet known what mechanism underlies the effect of drinking on performance and these may be different for different cognitive processes. We sought to elucidate the mechanisms involved by establishing at what stage of the drinking process cognitive performance is influenced. We examined the effect of mouth rinsing and mouth drying on subjective thirst and mood, visual attention and short term memory in children...
June 6, 2018: Physiology & Behavior
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