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https://www.readbyqxmd.com/read/27555146/ultrashort-acting-remifentanil-is-not-superior-to-long-acting-sufentanil-in-preserving-cognitive-function-a-randomized-study
#1
Linda A Rasmussen, Pia K Ryhammer, Jacob Greisen, Rajesh R Bhavsar, Anne-Grethe Lorentzen, Carl-Johan Jakobsen
STUDY OBJECTIVE: Postoperative cognitive dysfunction (POCD) is a well-known complication after cardiac surgery and may cause permanent disabilities with severe consequences for quality of life. The objectives of this study were, first, to estimate the frequency of POCD after on-pump cardiac surgery in patients randomized to remifentanil- or sufentanil-based anesthesia and, second, to evaluate the association between POCD and quality of recovery and perioperative hemodynamics, respectively...
September 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27043785/the-beneficial-effect-of-hypnosis-in-elective-cardiac-surgery-a-preliminary-study
#2
Ahmet Akgul, Beyhan Guner, Musa Çırak, Derya Çelik, Oya Hergünsel, Sevim Bedirhan
Background Single-session hypnosis has never been evaluated as a premedication technique in patients undergoing coronary artery bypass grafting (CABG). The aim of the present study was to evaluate the beneficial effects of clinical hypnotherapy on perioperative anxiety, pain perception, sedation, and necessity for ventilator assistance in patients undergoing CABG. Methods Double-blind, randomized, clinical trial was performed. Forty-four patients undergoing CABG surgery were randomized into two groups. The patients in group A received preprocedural hypnosis by an anesthesiologist...
April 4, 2016: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/27021174/remifentanil-compared-with-sufentanil-does-not-enhance-fast-track-possibilities-in-cardiac-surgery-a-randomized-study
#3
Rajesh Bhavsar, Pia Katerina Ryhammer, Jacob Greisen, Linda A Rasmussen, Carl-Johan Jakobsen
OBJECTIVE: Progressive cost containment has resulted in a growing interest for fast-track cardiac surgery. Ventilation time and length of stay (LOS) in the intensive care unit (ICU) are important factors in patient turnover, a more efficient use of resources, and early patient mobilization. However, LOS in ICU is not an objective measure because, in addition to medical factors, patient discharge may be guided by logistics and policy, and thus more objective measures are warranted. The authors hypothesized that remifentanil compared with sufentanil would reduce ventilation time and LOS in the ICU and that remifentanil would have beneficial effects on the overall quality of recovery...
October 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/26910295/the-impact-of-robotic-versus-conventional-coronary-artery-bypass-grafting-on-in-hospital-narcotic-use-a-propensity-matched-analysis
#4
Wissam N Raad, Stephen Forest, Marco Follis, Patricia Friedmann, Joseph J DeRose
OBJECTIVE: The aim of this study was to compare narcotic use in the perioperative hospital stay as a measure of pain in patients undergoing robotic versus conventional coronary artery bypass grafting (CABG). METHODS: Propensity score matching of patients undergoing robotically assisted CABG and conventional CABG over a period of 5 years was performed. A retrospective chart review was performed to identify the total amount of narcotics used by both groups calculated as morphine equivalent dosing (MED)...
March 2016: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/26455008/spinal-anesthesia-reduces-postoperative-delirium-in-opium-dependent-patients-undergoing-coronary-artery-bypass-grafting
#5
O Tabatabaie, N Matin, A Heidari, A Tabatabaie, A Hadaegh, S Yazdanynejad, K Tabatabaie
We investigated the effect of high spinal anesthesia on postoperative delirium in opium dependent patients undergoing coronary artery bypass grafting (CABG). The study was conducted in a tertiary referral university hospital on a population of 60 opium dependent patients undergoing CABG surgery. Patients were divided into two groups based on anesthesia protocol. One group were given general anesthesia (GA Group), the other group additionally received intrathecal morphine and bupivacaine (SGA Group). Postoperative delirium (POD) was defined as the main outcome of interest...
2015: Acta Anaesthesiologica Belgica
https://www.readbyqxmd.com/read/26345826/protective-effects-of-morphine-preconditioning-in-delayed-phase-on-myocardial-ischemia-reperfusion-injury-in-rabbits
#6
X-H Lu, K Ran, Y-Y Xiao, D-L Yang, Y-T Chang, K-M Duan, Y-W Ou
The aim of this study was to investigate the protective mechanisms of delayed-phase morphine preconditioning on myocardial ischemia-reperfusion injury. Thirty healthy male New Zealand white rabbits were randomly divided into three groups: a sham operation group (C), ischemia-reperfusion group (I/R), and delayed-phase morphine preconditioning group (M) (N = 10/group). Rabbits in the C group received thoracotomy for 160 min. Rabbits in the I/R group received left artery blockage for 40 min and reperfusion for 120 min...
2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/26303765/statin-induced-cardioprotection-against-ischemia-reperfusion-injury-potential-drug-drug-interactions-lesson-to-be-learnt-by-translating-results-from-animal-models-to-the-clinical-settings
#7
REVIEW
Gilad D Birnbaum, Itamar Birnbaum, Yumei Ye, Yochai Birnbaum
Numerous interventions have been shown to limit myocardial infarct size in animal models; however, most of these interventions have failed to have a significant effect in clinical trials. One potential explanation for the lack of efficacy in the clinical setting is that in bench models, a single intervention is studied without the background of other interventions or modalities. This is in contrast to the clinical setting in which new medications are added to the "standard of care" treatment that by now includes a growing number of medications...
2015: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/26125872/effect-of-morphine-preconditioning-in-the-delayed-phase-on-the-expression-of-p38-mitogen-activated-protein-kinase-in-a-rabbit-model-of-myocardial-ischemia-reperfusion-injury
#8
K Ran, Z X Gong, D L Yang, Y T Chang, K M Duan, Y W Ou
This study aimed to investigate the protective effects of delayed morphine preconditioning on myocardial ischemia-reperfusion injury. We randomly divided 30 rabbits into three groups with 10 rab-bits in each group as follows: sham operation group (C group), isch-emia-reperfusion group (I/R group), and morphine pretreatment group (M group). Rabbits in C Group received left coronary without blocking for 160 min. The left descending artery of rabbits in the I/R group was blocked for 40 min and reperfused for 120 min...
2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/25984279/serum-level-of-plasminogen-activator-inhibitor-type-1-in-addicted-patients-with-coronary-artery-disease
#9
Afsaneh Forood, Reza Malekpour-Afshar, Amin Mahdavi
BACKGROUND: Plasminogen activator inhibitor-1 (PAI-1) is a glycoprotein with inhibitory effects on the formation of plasmin from plasminogen by plasminogen activator. Thus, it prevents clot lysis in vessel walls. Several evidences prove the relationship between coronary artery disease and response to fibrinolytic therapy in patients with myocardial infarction (MI) with PAI-1 level. Opium addiction is one of the most important factors in causing MI and cardiovascular events. This is due to it causing imbalance between coagulation and anticoagulation factors in the blood...
July 2014: Addiction & Health
https://www.readbyqxmd.com/read/25971466/the-involvement-of-central-beta-endorphin-in-the-cardioprotective-effects-of-remote-preconditioning-mediated-by-the-intracerebroventricular-administration-of-morphine
#10
X Cheng, Y E Zhang, X Lu, Y Lu, Z Chen
BACKGROUND: Opioids can mimic the effects of remote cardiac preconditioning and mediate a subsequent reduction in myocardial infarct size. AIM: This study investigated the role of beta-endorphin (β-EP) in intracerebroventricular morphine cardioprotection. METHODS: Anesthetized, open-chest, male Sprague-Dawley rats were assigned to 1 of 9 treatment groups 3 days after intracerebroventricular catheter placement. Remote preconditioning was induced with 3 μg/kg of morphine...
May 2016: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/25918718/does-high-thoracic-epidural-analgesia-with-levobupivacaine-preserve-myocardium-a-prospective-randomized-study
#11
RANDOMIZED CONTROLLED TRIAL
Serife Gokbulut Bektas, Sema Turan, Umit Karadeniz, Burcin Ozturk, Soner Yavas, Dilan Biricik, Gul Sevim Saydam, Ozcan Erdemli
BACKGROUND: Our study aimed to compare HTEA and intravenous patient-controlled analgesia (PCA) in patients undergoing coronary bypass graft surgery (CABG), based on haemodynamic parameters and myocardial functions. MATERIALS AND METHODS: The study included 34 patients that were scheduled for elective CABG, who were randomly divided into 2 groups. Anesthesia was induced and maintained with total intravenous anesthesia in both groups while intravenous PCA with morphine was administered in Group 1 and infusion of levobupivacaine was administered from the beginning of the anesthesia in Group 2 by thoracic epidural catheter...
2015: BioMed Research International
https://www.readbyqxmd.com/read/25830118/premedication-with-oral-pregabalin-for-the-prevention-of-acute-postsurgical-pain-in-coronary-artery-bypass-surgery
#12
Mohsen Ziyaeifard, Mohammad Javad Mehrabanian, Seyedeh Zahra Faritus, Mehrdad Khazaei Koohpar, Rasool Ferasatkish, Heidar Hosseinnejad, Mohammadreza Mehrabanian
BACKGROUND: For coronary artery bypass grafting (CABG) sternotomy should be performed. The pain after surgery is severe and requires medical intervention. Use of the analgesics is limited by their side effects and studies suggest that prevention with some medications before surgery is effective in controlling the postoperative pain. OBJECTIVES: We investigated the efficacy of pregabalin administration before surgery in the treatment of acute postoperative pain after CABG surgery...
February 2015: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/25729675/intravenous-patient-controlled-remifentanil-versus-paracetamol-in-post-operative-pain-management-in-patients-undergoing-coronary-artery-bypass-graft-surgery
#13
Alireza Jahangiri Fard, Touraj Babaee, Seyed Mostafa Alavi, Ali Akbar Nasiri, Seyed Mohamad Mehran Ghoreishi, Noor Mohammad Noori, Maziar Mahjoubifard
BACKGROUND: Pain management after cardiac surgery has been based on parenteral long-acting opioids such as morphine. The other alternatives are paracetamol and remifentanil. OBJECTIVES: In this prospective, double-blind, randomized study, we compared the efficacy of intravenous patient-controlled analgesia (IV-PCA) paracetamol and remifentanil for post cardiac surgery pain relief. MATERIALS AND METHODS: One-hundred patients scheduled for elective coronary artery bypass grafting from May to October 2011, were randomized into two groups after the surgery...
December 2014: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/25671925/attenuation-of-haemodynamic-response-to-laryngoscopy-and-oral-endotracheal-intubation-in-coronary-artery-bypass-surgery-patients-intravenous-morphine-and-lidocaine-versus-intravenous-morphine-and-lidocaine-spray
#14
RANDOMIZED CONTROLLED TRIAL
Mujahid Ul Islam, Imtiaz Ahmad, Ali Azmat Shah, Ansa Islam
BACKGROUND: Sympathetic response associated with laryngoscopy and endotracheal intubation is recognized as a potential cause for a number of complications especially in coronary bypass surgery patients. Various methods have been used to attenuate these hemodynamic responses, The aim of our study was to compare lidocaine spray in addition to intravenous morphine on attenuating the hemodynamic response to laryngoscopy and endotracheal intubation with intravenous lidocaine and morphine in coronary artery bypass surgery patients...
July 2014: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/25638347/myocardial-infarction-symptoms-and-treatments
#15
Lei Lu, Min Liu, RongRong Sun, Yi Zheng, Peiying Zhang
Myocardial infarction (MI) is a term used for an event of heart attack which is due to formation of plaques in the interior walls of the arteries resulting in reduced blood flow to the heart and injuring heart muscles because of lack of oxygen supply. The symptoms of MI include chest pain, which travels from left arm to neck, shortness of breath, sweating, nausea, vomiting, abnormal heart beating, anxiety, fatigue, weakness, stress, depression, and other factors. The immediate treatment of MI include, taking aspirin, which prevents blood from clotting, and nitro-glycerin to treat chest pain and oxygen...
July 2015: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/25566704/the-analgesic-efficacy-of-continuous-presternal-bupivacaine-infusion-through-a-single-catheter-after-cardiac-surgery
#16
RANDOMIZED CONTROLLED TRIAL
Dalia Abdelhamid Nasr, Hadeel Magdy Abdelhamid, Mai Mohsen, Ahmad Helmy Aly
BACKGROUND: Median sternotomy, sternal spreading, and sternal wiring are the main causes of pain during the early recovery phase following cardiac surgery. AIM: This study was designed to evaluate the analgesic efficacy of continuous presternal bupivacaine infusion through a single catheter after parasternal block following cardiac surgery. MATERIALS AND METHODS: The total of 40 patients (American Society of Anesthesiologist status II, III), 45-60 years old, undergoing coronary-artery bypass grafting were enrolled in this prospective, randomized, double-blind study...
January 2015: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/25558674/-perspective-of-use-of-agonists-of-adenosine-and-opioid-receptors-for-prevention-of-reperfusion-damages-of-heart-analysis-of-experimental-and-clinical-data
#17
REVIEW
L N Maslov, A G Mrochek, I G Khaliulin, A V Krylatov, A G Portnichenko, E Chausskaia, N V Naryzhnaia, A S Gorbunov, S Iu Tsibulnikov
In Russia inhospital lethality after acute myocardial infarction is 16.5-16.7%. The part of patients perishes even after recanalisation of infarct-related coronary artery as a result of reperfusion cardiac injury. Experimental data indicate that adenosine receptor agonists and opioids can prevent reperfusion damages of heart that is mimic postconditioning phenomena. Data of clinical observation show that adenosine during intravenous infusion or intracoronary administration during thrombolysis or percutaneous coronary intervention exert infarct reducing effect and eliminate manifestation of of "no-reflow" phenomenon...
2014: Vestnik Rossiĭskoĭ Akademii Meditsinskikh Nauk
https://www.readbyqxmd.com/read/25346897/comparing-the-effects-of-morphine-sulfate-and-diclofenac-suppositories-on-postoperative-pain-in-coronary-artery-bypass-graft-patients
#18
Vali Imantalab, Ali Mirmansouri, Abbas Sedighinejad, Bahram Naderi Nabi, Farnoush Farzi, Hadi Atamanesh, Nassir Nassiri
BACKGROUND: Simple and efficient way of pain management after Coronary Artery Bypass Graft (CABG) surgery is an important aspect of patients' care. OBJECTIVES: This study aimed to compare the effects of morphine and diclofenac suppositories on postoperative pain management. PATIENTS AND METHODS: In this double-blinded clinical trial study, 120 patients aged 30-65 years old, undergone CABG, were equally divided into two groups of A (morphine) and B (diclofenac)...
October 2014: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/25276699/impact-of-patient-controlled-analgesia-on-pain-relief-after-coronary-artery-bypass-graft-surgery-a-randomized-clinical-trial
#19
Sima Lakdizaji, Vahid Zamanzadeh, Mohammad Zia Totonchi, Atoosa Hosseinzadeh
INTRODUCTION: Pain has been pointed out as one of the concerns of cardiac surgery patients. Acute pain management has been a challenge for health professionals and several regiments have been described. We designed this study to evaluate the effectiveness of pain control with patient-controlled analgesia (PCA) versus conventional nurse-controlled analgesia (NCA) during the postoperative period in the intensive care unit (ICU) after coronary artery bypass graft (CABG) surgery. METHODS: In this randomized clinical trial, 80 elective CABG candidates were selected by convenience sampling...
December 2012: Journal of Caring Sciences
https://www.readbyqxmd.com/read/25214258/remote-intrathecal-morphine-preconditioning-confers-cardioprotection-via-spinal-cord-nitric-oxide-cyclic-guanosine-monophosphate-protein-kinase-g-pathway
#20
Yao Lu, Jun Hu, Ye Zhang, Chun Shan Dong, Gordon Tin Chun Wong
BACKGROUND: Remote intrathecal morphine preconditioning (RMPC) induces cardioprotection, but the underlying mechanisms of this effect is unknown. The aim of this study was to investigate the role of spinal cord nitric oxide/cyclic guanosine monophosphate/protein kinase G (NO/cGMP/PKG) signal pathway in the cardioprotection of RMPC in rats. MATERIALS AND METHODS: Anesthetized, open chest, male Sprague-Dawley rats were assigned to one of eight treatment groups 3 d after intrathecal catheter placement...
January 2015: Journal of Surgical Research
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