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Cardiovascular risk HIV

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https://www.readbyqxmd.com/read/28828963/soluble-tweak-may-predict-carotid-atherosclerosis-in-treated-hiv-infection
#1
Sahera Dirajlal-Fargo, Abdus Sattar, Manjusha Kulkarni, Nicholas Funderburg, Grace A McComsey
BACKGROUND: Soluble Tumor Necrosis Factor Weak Inducer of Apoptosis (sTWEAK) has been proposed as a novel biomarker of cardiovascular disease risk. This study compares levels of sTWEAK, sCD163 and the sCD163/sTWEAK ratio in HIV-infected and uninfected patients and their associations with cardiovascular and inflammatory factors. METHODS: The data for our analysis come from 274 HIV-infected adults and 59 controls. HIV participants were on stable antiretroviral therapy (ART)...
August 22, 2017: HIV Clinical Trials
https://www.readbyqxmd.com/read/28817947/mortality-and-health-service-use-following-acute-myocardial-infarction-among-persons-with-hiv-a-population-based-study
#2
Caroline Jeon, Cindy Lau, Claire E Kendall, Ann N Burchell, Ahmed M Bayoumi, Mona Loutfy, Sean Rourke, Tony Antoniou
Background People with HIV have higher rates of acute myocardial infarction (AMI) than HIV-negative individuals. We compared mortality risk and health service use following AMI among people with and without HIV between January 1, 2002 and March 31, 2015. Methods We conducted a population-based study using Ontario's administrative databases. Our primary outcomes were risk of inpatient death and death at 30 days following hospital discharge. In secondary analyses, we compared use of revascularization procedures within 90 days of AMI, as well as readmission or emergency department visits for heart disease and cardiology follow-up within 90 days of discharge...
August 17, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28817706/hiv-infection-antiretroviral-therapy-and-measures-of-endothelial-function-inflammation-metabolism-and-oxidative-stress
#3
Andrew Dysangco, Ziyue Liu, James H Stein, Michael P Dubé, Samir K Gupta
BACKGROUND: HIV-infected patients have an increased risk of cardiovascular disease (CVD). Impaired endothelial function is an early risk factor for CVD in the general population. It is presumed that HIV infection is associated with impaired endothelial function, but results have been inconsistent. OBJECTIVES: Our objectives were to determine the relationships between HIV infection, virologic suppression with antiretroviral therapy (ART), in vivo measures of conduit artery and microvascular endothelial function, and circulating biomarkers of pathways associated with CVD...
2017: PloS One
https://www.readbyqxmd.com/read/28801428/relationship-between-estimated-cardiovascular-disease-risk-and-insulin-resistance-in-a-black-african-population-living-with-hiv-a-cross-sectional-study-from-cameroon
#4
Steve Raoul Noumegni, Jean Joel Bigna, Vicky Jocelyne Ama Moor Epse Nkegoum, Jobert Richie Nansseu, Felix K Assah, Ahmadou Musa Jingi, Magellan Guewo-Fokeng, Steve Leumi, Jean-Claude Katte, Mesmin Y Dehayem, Liliane Mfeukeu Kuate, Andre Pascal Kengne, Eugene Sobngwi
OBJECTIVES: Cardiovascular disease (CVD) and metabolic diseases are growing concerns among patients with HIV infection as a consequence of the improving survival of this population. We aimed to assess the relationship between CVD risk and insulin resistance in a group of black African individuals with HIV infection. METHODS: This cross-sectional study involved patients with HIV infection aged 30-74 years and followed up at the Yaoundé Central Hospital, Cameroon...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28799999/features-of-cardiovascular-disease-in-low-income-and-middle-income-countries-in-adults-and-children-living-with-hiv
#5
Andrew W McCrary, Chidozie U Nduka, Saverio Stranges, Gerald S Bloomfield
PURPOSE OF REVIEW: The current article addresses crucial issues in identifying risk of cardiovascular disease (CVD) in people living with HIV in low-income and middle-income countries (LMICs). These issues are in need of urgent attention to advance our knowledge and inform actions to mitigate CVD in this population. We address CVDs in adults living with HIV as well as the unique aspects pertaining to children living with HIV (CLHIV), a group sorely under-represented in this field. RECENT FINDINGS: CVDs affecting adults such as hypertension, dyslipidemia, coronary artery disease, and heart failure, in addition to myocardial dysfunction, vascular diseases, and autoimmune phenomena are also being reported in CLHIV...
August 10, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/28799997/epidemiology-of-ischemic-heart-disease-in-hiv
#6
Virginia A Triant, Steven K Grinspoon
PURPOSE OF REVIEW: The purpose of this review is to summarize and synthesize recent data on the risk of ischemic heart disease (IHD) in HIV-infected individuals. RECENT FINDINGS: Recent studies in the field demonstrate an increasing impact of cardiovascular disease (CVD) on morbidity and mortality in HIV relative to AIDS-related diagnoses. Studies continue to support an approximately 1.5 to two-fold increased risk of IHD conferred by HIV, with specific risk varying by sex and virologic/immunologic status...
August 10, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/28799996/tobacco-illicit-drugs-use-and-risk-of-cardiovascular-disease-in-patients-living-with-hiv
#7
Sergio Raposeiras-Roubín, Emad Abu-Assi, Andrés Iñiguez-Romo
PURPOSE OF REVIEW: There is a strong link between HIV, smoking and illicit drugs. This association could be clinically relevant as it may potentiate the risk of cardiovascular diseases (CVD). The purpose of this review is to bring readers up-to-date on issues concerning the cardiovascular risk associated with tobacco and illicit drugs in patients living with HIV (PLHIV), examinating the studies related to this topic published in the last year. RECENT FINDINGS: There is a strong association between smoking and atherosclerotic disease in PLHIV, reducing life expectancy secondary to CVD by up to 6 years...
August 10, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/28797021/personalized-risk-index-for-neurocognitive-decline-among-people-with-well-controlled-hiv-infection
#8
Tracy Yuen, Marie-Josée Brouillette, Lesley K Fellows, Ronald J Ellis, Scott Letendre, Robert Heaton, Nancy Mayo
BACKGROUND: Little is known about the predictors of neurocognitive decline in HIV+ individuals with good virological control. Identification of modifiable risk factors would allow targeted interventions to reduce the risk of decline in higher risk individuals. The objective of this study was to develop a risk index to predict neurocognitive decline over 3 years in aviremic HIV+ individuals. METHODS: As part of the CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER) study, HIV+ adults completed clinical evaluation and neuropsychological tests every 6 months...
September 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28796027/heart-fat-in-hiv-marker-or-mediator-of-risk
#9
Jonathan Buggey, Chris T Longenecker
PURPOSE OF REVIEW: The review aims to summarize the literature describing the clinical impact of cardiac fat depots in patients with HIV infection. RECENT FINDINGS: People living with HIV (PLHIV) have accelerated rates of cardiovascular disease, and are prone to the development of ectopic fat deposition. Specifically, PLHIV have higher volumes of epicardial and intracardiac fat quantified by noninvasive imaging. Higher volumes of epicardial fat may be related to antiretroviral therapy duration and chronic inflammation, independently of other measures of body adiposity such as BMI...
August 8, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/28793863/cardiovascular-risk-and-dyslipidemia-among-persons-living-with-hiv-a-review
#10
REVIEW
Paolo Maggi, Antonio Di Biagio, Stefano Rusconi, Stefania Cicalini, Maurizio D'Abbraccio, Gabriella d'Ettorre, Canio Martinelli, Giuseppe Nunnari, Laura Sighinolfi, Vincenzo Spagnuolo, Nicola Squillace
BACKGROUND: Aim of this review is to focus the attention on people living with HIV infection at risk of developing a cardiovascular event. What is or what would be the most suitable antiretroviral therapy? Which statin or fibrate to reduce the risk? How to influence behavior and lifestyles? DISCUSSION: Prevention of cardiovascular disease (CVD) risk remains the first and essential step in a medical intervention on these patients. The lifestyle modification, including smoking cessation, increased physical activity, weight reduction, and the education on healthy dietary practices are the main instruments...
August 9, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28779949/cardiovascular-disease-in-patients-with-hiv
#11
REVIEW
Flavia Ballocca, Fabrizio D'Ascenzo, Sebastiano Gili, Walter Grosso Marra, Fiorenzo Gaita
With the progressive increase in life expectancy of HIV-positive patient, thanks to "highly active antiretroviral therapy" (HAART), new comorbidities, and especially cardiovascular diseases (CVDs) are emerging as an important concern. An increased risk of coronary artery disease, often in a younger age, has been observed in this population. The underlying pathophysiology is complex and partially still unclear, with the interaction of viral infection-and systemic inflammation-antiretroviral therapy and traditional risk factors...
June 12, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28763308/revascularization-strategies-and-in-hospital-management-in-acute-coronary-syndromes-complicated-by-hemophilia-a-or-hemophilia-b
#12
Matthew J Reilley, Anne Blair, William H Matthai, Rolando Vega, Meghan Buckley, Phyllis A Gimotty, Patrick F Fogarty
: Among adult patients with hemophilia A and hemophilia B the emergent management of acute coronary syndromes (ACSs) is challenging, and exposure to antithrombotic agents and/or revascularization procedures may confer an enhanced risk of bleeding. We sought to identify clinical characteristics and in-hospital outcomes among ACS patients with hemophilia A/hemophilia B, compared with matched noncoagulopathic ACS controls. Case discharges from the Nationwide Inpatient Sample, Healthcare Cost and Utilization Project, Agency for Healthcare Research and Quality (1998-2011) had International Classification of Diseases, 9th Revision codes for hemophilia A/hemophilia B and ACS...
July 29, 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/28762691/hiv-associated-complications-a-systems-based-approach
#13
REVIEW
Carolyn Chu, Lealah C Pollock, Peter A Selwyn
Persons with human immunodeficiency virus (HIV) infection often develop complications related directly to the infection, as well as to treatment. Aging, lifestyle factors, and comorbidities increase the risk of developing chronic conditions such as diabetes mellitus and chronic kidney disease. HIV-associated neurologic complications encompass a wide spectrum of pathophysiology and symptomatology. Cardiovascular and pulmonary conditions are common among persons with HIV infection. Although some specific antiretroviral medications have been linked to disease development, traditional risk factors (e...
August 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28758024/serum-lipid-and-glucose-profiles-in-hiv-positive-nigerian-children
#14
EDITORIAL
Olukemi O Ige, Christopher S Yilgwan, Augustine O Ebonyi, Ruth Adah, Idris Adedeji, Esther S Yiltok, Stephen Oguche, Fidelia Bode-Thomas
OBJECTIVES: To describe the fasting serum lipid and glucose profiles of HIV-positive Nigerian children and determine the prevalence and risk factors for dyslipidaemia and hyperglycaemia, which are risk factors for cardiovascular diseases. METHODS: This was a comparative cross-sectional study carried out at the Paediatric Infectious Disease Clinic (PIDC) of the Jos University Teaching Hospital (JUTH) for HIV-positive children and at two primary schools in Jos for HIV-negative children as controls...
July 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28754089/predictive-factors-and-prevalence-of-microalbuminuria-in-hiv-infected-patients-a-cross-sectional-analysis
#15
Katia Falasca, Marta Di Nicola, Italo Porfilio, Claudio Ucciferri, Elisabetta Schiaroli, Chiara Gabrielli, Daniela Francisci, Jacopo Vecchiet
BACKGROUND: Renal dysfunction is a common problem in the HIV+ population, due to the effect of both the HIV virus and the several classes of ARV drugs such as tenofovir (TDF). It is also known that the presence of renal damage correlates with cardiovascular risk and therefore with the risk of mortality of the patients accordingly. The detection of early renal damage is very important. Albuminuria and microalbuminuria are markers of early kidney disease and cardiovascular risk. The aim of the study is to evaluate the prevalence of microalbuminuria in a large polycentric sample, of unselected and consecutive HIV-patients followed as outpatients, and to assess its association with different therapeutic regimens...
July 28, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28750777/prevalence-of-periodontitis-dental-caries-and-peri-implant-pathology-and-their-relation-with-systemic-status-and-smoking-habits-results-of-an-open-cohort-study-with-22009-patients-in-a-private-rehabilitation-center
#16
Miguel de Araújo Nobre, Paulo Maló
OBJECTIVES: This investigation, based on a 3-year epidemiological surveillance open cohort study, aimed to provide an insight of the prevalence of periodontitis, dental caries and peri-implant pathology and to compare inferentially between healthy and systemic compromised patients. METHODS: A total of 22009 patients were observed consisting in 9035 men (41.1%) and 12974 women (58.9%) with an average age of 48.5 years (standard deviation of 15.6 years). The prevalence of the 3 chronical oral diseases was calculated...
July 24, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28749986/the-role-of-the-tissue-factor-and-its-inhibitor-in-the-development-of-subclinical-atherosclerosis-in-people-living-with-hiv
#17
Katarzyna Barska, Wiesława Kwiatkowska, Brygida Knysz, Katarzyna Arczyńska, Maciej Karczewski, Wojciech Witkiewicz
INTRODUCTION: HIV infection is associated with an increased risk of cardiovascular disease in connection with atherosclerosis and thromboembolic complications. The pathogenesis of atherosclerosis is still unclear in this group of patients. Studies on pathogenesis of atherosclerosis in the general population emphasize the role of the extrinsic pathway of blood coagulation, particularly the tissue factor (TF) and tissue factor pathway inhibitor (TFPI). The effect of persistent activation of the immune system on enhanced expression of TF on the surface of monocytes in subjects infected with HIV is known to be correlated with the level of HIV RNA in blood serum...
2017: PloS One
https://www.readbyqxmd.com/read/28738800/benchmarked-performance-charts-using-principal-components-analysis-to-improve-the-effectiveness-of-feedback-for-audit-data-in-hiv-care
#18
Skevi Michael, Mark Gompels, Caroline Sabin, Hilary Curtis, Margaret T May
BACKGROUND: Feedback tools for clinical audit data that compare site-specific results to average performance over all sites can be useful for quality improvement. Proposed tools should be simple and clearly benchmark the site's performance, so that a relevant action plan can be directly implemented to improve patient care services. We aimed to develop such a tool in order to feedback data to UK HIV clinics participating in the 2015 British HIV Association (BHIVA) audit assessing compliance with the 2011 guidelines for routine investigation and monitoring of adult HIV-1- infected individuals...
July 24, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28736507/national-mortality-burden-due-to-communicable-non-communicable-and-other-diseases-in-ethiopia-1990-2015-findings-from-the-global-burden-of-disease-study-2015
#19
Awoke Misganaw, Tilahun N Haregu, Kebede Deribe, Gizachew Assefa Tessema, Amare Deribew, Yohannes Adama Melaku, Azmeraw T Amare, Semaw Ferede Abera, Molla Gedefaw, Muluken Dessalegn, Yihunie Lakew, Tolesa Bekele, Mesoud Mohammed, Biruck Desalegn Yirsaw, Solomon Abrha Damtew, Kristopher J Krohn, Tom Achoki, Jed Blore, Yibeltal Assefa, Mohsen Naghavi
BACKGROUND: Ethiopia lacks a complete vital registration system that would assist in measuring disease burden and risk factors. We used the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015) estimates to describe the mortality burden from communicable, non-communicable, and other diseases in Ethiopia over the last 25 years. METHODS: GBD 2015 mainly used cause of death ensemble modeling to measure causes of death by age, sex, and year for 195 countries...
2017: Population Health Metrics
https://www.readbyqxmd.com/read/28732536/national-mortality-burden-due-to-communicable-non-communicable-and-other-diseases-in-ethiopia-1990-2015-findings-from-the-global-burden-of-disease-study-2015
#20
Awoke Misganaw, Tilahun N Haregu, Kebede Deribe, Gizachew Assefa Tessema, Amare Deribew, Yohannes Adama Melaku, Azmeraw T Amare, Semaw Ferede Abera, Molla Gedefaw, Muluken Dessalegn, Yihunie Lakew, Tolesa Bekele, Mesoud Mohammed, Biruck Desalegn Yirsaw, Solomon Abrha Damtew, Kristopher J Krohn, Tom Achoki, Jed Blore, Yibeltal Assefa, Mohsen Naghavi
BACKGROUND: Ethiopia lacks a complete vital registration system that would assist in measuring disease burden and risk factors. We used the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015) estimates to describe the mortality burden from communicable, non-communicable, and other diseases in Ethiopia over the last 25 years. METHODS: GBD 2015 mainly used cause of death ensemble modeling to measure causes of death by age, sex, and year for 195 countries...
July 21, 2017: Population Health Metrics
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