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Vancomycin resistance enterococci

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https://www.readbyqxmd.com/read/28428726/successful-treatment-of-prosthetic-joint-infection-due-to-vancomycin-resistant-enterococci-with-tedizolid
#1
Sheng Si, Michael J Durkin, Maureen M Mercier, Melanie L Yarbrough, Stephen Y Liang
Few antibiotic options exist for the management of infections due to vancomycin-resistant enterococci (VRE). We describe a case involving the safe and successful use of tedizolid, a new oxazolidinone, to treat VRE prosthetic joint infection.
March 2017: Infectious Diseases in Clinical Practice: IDCP
https://www.readbyqxmd.com/read/28423435/-pathogen-spectrum-of-complex-wounds-in-germany-from-war-zones
#2
Hans Joachim Riesner, Benedikt Friemert, Patricia Lang, Hans Georg Palm, Arnold J Suda
Background Treatment of the injured from war zones with wounds with multi-resistant pathogens is becoming more common in Germany, especially in German Armed Forces Hospitals. In most cases, the pre-treatment of these patients has been inadequate and they have a high load of rare pathogens. In Germany, hospitals have to evaluate these pathogens by law. The aim of this study was to review current German guidelines and data on the array of pathogens of complex trauma wounds in Germany and to compare patients with wounds and multi-resistant pathogens from war zones treated in Germany...
April 19, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28412932/isolation-of-enterococci-their-antimicrobial-susceptibility-patterns-and-associated-factors-among-patients-attending-at-the-university-of-gondar-teaching-hospital
#3
Amelework Yilema, Feleke Moges, Sisay Tadele, Mengistu Endris, Afework Kassu, Wondwossen Abebe, Getnet Ayalew
BACKGROUND: Enterococci become clinically important especially in immune compromised patients and important causes of nosocomial infections. Data on the prevalence, antimicrobial susceptibility patterns and associated factors of enterococci are scarce in Ethiopia. METHODS: A hospital based cross-sectional study was conducted at the University of Gondar Teaching Hospital from February 28, 2014 to May 1, 2014. Pretested structured questionnaire was used to collect socio-demographic data and possible associated factors of enterococci infections...
April 17, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28406232/peptidoglycan-o-acetylation-increases-in-response-to-vancomycin-treatment-in-vancomycin-resistant-enterococcus-faecalis
#4
James D Chang, Erin E Foster, Ashley G Wallace, Sung Joon Kim
Vancomycin resistance is conferred upon vancomycin-resistant enterococci (VRE) through the replacement of peptidoglycan (PG) stem terminal d-Ala-d-Ala with d-Ala-d-Lac. The d-Ala-d-Lac incorporation can affect both the fitness and virulence of VRE. Here we comprehensively investigate the changes to PG composition in vancomycin-resistant Enterococcus faecalis following the growth in presence of vancomycin using liquid chromatography-mass spectrometry. Using high-resolution mass spectrometry, 104 unique muropeptides fragments were identified and the relative abundance of each fragment was accurately quantified by integrating the ion current of a selected ion using extracted-ion chromatogram...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28403894/antibiotic-resistant-airborne-bacteria-and-their-multidrug-resistance-pattern-at-university-teaching-referral-hospital-in-south-ethiopia
#5
Fithamlak Bisetegen Solomon, Fiseha Wada Wadilo, Amsalu Amache Arota, Yishak Leka Abraham
BACKGROUND: Hospitals provide a reservoir of microorganisms, many of which are multi-resistant to antibiotics. Emergence of multi-drug resistant strains in a hospital environment, particularly in developing countries is an increasing problem to infection treatment. This study aims at assessing antibiotic resistant airborne bacterial isolates. METHODS: A cross-sectional study was conducted at Wolaita Sodo university teaching and referral Hospital. Indoor air samples were collected by using passive air sampling method...
April 12, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28397853/hydrodynamics-of-the-vana-type-vans-histidine-kinase-an-extended-solution-conformation-and-first-evidence-for-interactions-with-vancomycin
#6
Mary K Phillips-Jones, Guy Channell, Claire J Kelsall, Charlotte S Hughes, Alison E Ashcroft, Simon G Patching, Vlad Dinu, Richard B Gillis, Gary G Adams, Stephen E Harding
VanA-type resistance to glycopeptide antibiotics in clinical enterococci is regulated by the VanSARA two-component signal transduction system. The nature of the molecular ligand that is recognised by the VanSA sensory component has not hitherto been identified. Here we employ purified, intact and active VanSA membrane protein (henceforth referred to as VanS) in analytical ultracentrifugation experiments to study VanS oligomeric state and conformation in the absence and presence of vancomycin. A combination of sedimentation velocity and sedimentation equilibrium in the analytical ultracentrifuge (SEDFIT, SEDFIT-MSTAR and MULTISIG analysis) showed that VanS in the absence of the ligand is almost entirely monomeric (molar mass M = 45...
April 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28389190/detection-of-vancomycin-resistant-enterococci-vre-in-stool-specimens-submitted-for-clostridium-difficile-toxin-testing
#7
Sevim Özsoy, Arzu İlki
The aim of this study was to determine the association between Clostridium difficile (C. difficile) and vancomycin-resistant Enterococcus (VRE) and efficacy of screening stools submitted for C. difficile toxin assay for prevalence of VRE. Between April 2012 and February 2014, 158 stool samples submitted for C. difficile toxin to the Marmara University Microbiology Laboratory, were included in the study. Stool samples were analyzed by enzyme immuno assay test; VIDAS (bioMerieux, France) for Toxin A&B. Samples were inoculated on chromID VRE (bioMerieux, France) and incubated 24h at 37°C...
March 17, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/28389093/risk-factors-for-kpc-producing-enterobacteriaceae-acquisition-and-infection-in-a-healthcare-setting-with-possible-local-transmission-a-case-control-study
#8
K M Cronin, Y S Poy Lorenzo, M E Olenski, A E Bloch, K Visvanathan, M J Waters, K L Buising
BACKGROUND: Reports of Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-Kp) in Australia were previously uncommon, with cases imported sporadically by travellers from higher prevalence countries. AIM: The study institution reported the first outbreak of KPC-Kp in Australia. The aim of this study was to identify risk factors for KPC-Kp colonization and infection using a matched case-control study. METHODS: The study included all hospitalized patients with KPC-Kp colonization or infection from January 2012 to September 2015...
February 16, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28384858/antimicrobial-resistance-surveillance-among-intensive-care-units-of-a-tertiary-care-hospital-in-southern-india
#9
Kailash Moolchandani, Apurba Sankar Sastry, R Deepashree, Sujatha Sistla, B N Harish, Jharna Mandal
INTRODUCTION: Hospital Acquired Infections (HAIs) are the rising threat in the health care facilities across the globe. As most Intesive Care Unit (ICU) patients are frequently on broad spectrum antimicrobials, this induces selective antibiotic pressure which leads to development of Antimicrobial Resistance (AMR) among the microorganisms of ICUs. AIM: To study the occurrence of different types of HAIs in patients admitted to various ICUs of JIPMER and the AMR pattern of the bacterial pathogens isolated from them...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28381710/search-for-novel-antibacterial-compounds-and-targets
#10
Teruo Kuroda, Wakano Ogawa
 Drug-resistant bacteria including methicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant Pseudomonas aeruginosa, and vancomycin-resistant enterococci (VRE) have been spreading; however, the development of new antibacterial drugs has not progressed accordingly. Novel antibacterial drugs or their candidate seeds need to be developed for effective antibiotic therapy. Under these conditions, the search for novel compounds and novel targets is important. In Okayama University, as a part of the Drug Discovery for Intractable Infectious Diseases project, we are proceeding with the development of antibacterial drugs for the treatment of drug-resistant bacterial infections...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28378152/-development-of-antimicrobial-resistance-in-germany-what-is-the-current-situation
#11
F Maechler, C Geffers, F Schwab, L-A Peña Diaz, M Behnke, P Gastmeier
BACKGROUND: The frequency of multidrug-resistant organisms (MDRO) is increasing in Germany and worldwide. OBJECTIVES: Presentation of MDRO resistance rates and prevalence in Germany MATERIALS AND METHODS: Results from the Antibiotic Resistance Surveillance (ARS) and Hospital Infection Surveillance Systems (Krankenhausinfektions-Surveillance-Systems, KISS) and from recent prevalence surveys are presented. RESULTS: MRSA-resistance rates and the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) have remained at a stable level over the last few years...
April 4, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/28377166/activity-of-telavancin-against-gram-positive-pathogens-isolated-from-bone-and-joint-infections-in-north-american-latin-american-european-and-asia-pacific-nations
#12
Ronald N Jones, Robert K Flamm, Mariana Castanheira, Helio S Sader, Jennifer I Smart, Rodrigo E Mendes
Telavancin was tested against a worldwide collection of Gram-positive pathogens (967) isolated from bone and joint infections (BJI). Most BJI isolates were from the United States (US) (49.9%) followed by Europe (26.4%), Latin America (LATAM; 14.4%), and Asia-Pacific (APAC; 9.3%). Organisms were tested by broth microdilution susceptibility methods. S. aureus (66.4%; range of 48.9% in APAC to 71.2% in LATAM) was the most common pathogen and had a 35.7% methicillin resistance (MRSA) rate and telavancin MIC50/90 of 0...
March 8, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28369204/prediction-of-bloodstream-infection-due-to-vancomycin-resistant-enterococci-in-patients-undergoing-leukemia-induction-or-hematopoietic-stem-cell-transplantation
#13
Brandon J Webb, Regan Healy, Jacob Majers, Zachary Burr, Michaela Gazdik, Bert Lopansri, Daanish Hoda, Finn Bo Petersen, Clyde Ford
Background.: Bloodstream infection (BSI) due vancomycin-resistant Enterococcus (VRE) is an important complication of hematologic malignancy. Determining when to use empiric anti-VRE antibiotic therapy in this population remains a clinical challenge. Methods.: A single-center cohort representing 664 admissions for induction or hematopoietic stem cell transplant (HSCT) from 2006-2014 was selected. We derived a prediction score using risk factors for VRE BSI and evaluated the model's predictive performance by calculating it for each of 16,232 BSI at-risk inpatient days...
March 20, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28366613/secular-trends-of-bloodstream-infections-during-neutropenia-in-15-181-haematopoietic-stem-cell-transplants-13-year-results-from-a-european-multicentre-surveillance-study-onko-kiss
#14
Maja Weisser, Christian Theilacker, Sarah Tschudin Sutter, Regina Babikir, Hartmut Bertz, Tim Götting, Markus Dettenkofer, Winfried V Kern, Andreas F Widmer
OBJECTIVES: Antibacterial resistance is emerging in patients undergoing haematopoietic stem cell transplantation (HSCT) and most data on the epidemiology of bloodstream infections (BSI)-causing pathogens come from retrospective, single-centre studies. Aim of this study is to investigate trends in the epidemiology of BSI in HSCT recipients from a prospective multicentre cohort. METHODS: From 2002 to 2014 we investigated changes in the incidence of causative organisms of BSI during neutropenia among adult HSCT recipients...
March 30, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28351179/vancomycin-resistant-enterococci-in-acute-myeloid-leukemia-and-myelodysplastic-syndrome-patients-undergoing-induction-chemotherapy-with-idarubicin-and-cytarabine
#15
Ronald W Heisel, Robert R Sutton, Gerard P Mascara, Daniel G Winger, David R Weber, Seah H Lim, Louise-Marie Oleksiuk
We conducted a retrospective study to determine the risk factors associated with vancomycin-resistant enterococci (VRE) acquisition/infection in newly diagnosed acute myeloid leukemia and myelodysplastic syndrome patients undergoing chemotherapy with the 7 + 3 regimen of cytarabine and idarubicin. Although only 2.5% (6/235) patients were colonized with VRE on admission, 59% (134/229) of patients acquired VRE during their hospitalization. Multivariable analysis identified the use of intravenous vancomycin (p = ...
March 28, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28350900/gram-positive-bacterial-infections-research-priorities-accomplishments-and-future-directions-of-the-antibacterial-resistance-leadership-group
#16
Sarah B Doernberg, Thomas P Lodise, Joshua T Thaden, Jose M Munita, Sara E Cosgrove, Cesar A Arias, Helen W Boucher, G Ralph Corey, Franklin D Lowy, Barbara Murray, Loren G Miller, Thomas L Holland
Antimicrobial resistance in gram-positive bacteria remains a challenge in infectious diseases. The mission of the Gram-Positive Committee of the Antibacterial Resistance Leadership Group (ARLG) is to advance knowledge in the prevention, management, and treatment of these challenging infections to improve patient outcomes. Our committee has prioritized projects involving methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) due to the scope of the medical threat posed by these pathogens...
March 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28346839/characterization-of-vancomycin-resistant-enterococcus-faecalis-and-enterococcus-faecium-isolated-from-fresh-produces-and-human-fecal-samples
#17
Min-Chan Kim, Min-Hyeok Cha, Jae-Gee Ryu, Gun-Jo Woo
Increased enterococcal infections in hospitals and multidrug-resistant and vancomycin-resistant enterococci (VRE) isolated from humans, animals, and food sources raised public health concern on the presence of VRE in multiple sources. We performed a comparative analysis of the antimicrobial resistance and genetics of VRE isolates derived from fresh produce and human fecal samples. Of 389 Enterococcus isolates, 8 fecal and 3 produce isolates were resistant to vancomycin and teicoplanin; all harbored vanA gene...
April 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28339914/infant-colonization-with-methicillin-resistant-staphylococcus-aureus-or-vancomycin-resistant-enterococci-preceding-neonatal-intensive-care-unit-discharge
#18
Sarah A Clock, Haomiao Jia, Sameer Patel, Yu-Hui Ferng, Luis Alba, Susan Whittier, Patricia DeLaMora, Setareh Tabibi, Jeffrey Perlman, David Paul, Theoklis Zaoutis, Elaine Larson, Lisa Saiman
Rates of colonization with methicillin-resistant Staphylococcus aureus (MRSA) and/or vancomycin-resistant enterococci (VRE) were determined for 1320 infants within 7 days of neonatal intensive care unit discharge. Overall, 4% and 1% of the infants were colonized with MRSA or VRE, respectively. Predictors identified in fixed-effects models were surgery during hospitalization (for MRSA colonization) and prolonged antimicrobial treatment (for VRE colonization).
March 1, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28336313/vancomycin-resistant-enterococci-colonisation-risk-factors-and-risk-for-infection-among-hospitalised-paediatric-patients-a-systematic-review-and-meta-analysis
#19
REVIEW
Myrto Eleni Flokas, Spyridon A Karageorgos, Marios Detsis, Michail Alevizakos, Eleftherios Mylonakis
The objective of this study was to estimate the rate and significance of colonisation with vancomycin-resistant enterococci (VRE) among hospitalised children. The PubMed and EMBASE databases were systematically searched (last accessed on 29 May 2016) to identify studies evaluating VRE colonisation of the gastrointestinal tract of hospitalised children in non-outbreak periods. Of 945 non-duplicate citations, 19 studies enrolling 20 234 children were included. The overall and paediatric intensive care unit (PICU) rate of VRE colonisation were both 5% [95% confidence interval (CI) 3-8% overall and 95% CI 2-9% in the PICU] but was 23% in haematology/oncology units (95% CI 18-29%)...
March 20, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28332345/high-incidence-of-virulence-factors-among-clinical-enterococcus-faecalis-isolates-in-southwestern-iran
#20
Hamid Heidari, Somayeh Hasanpour, Hadi Sedigh Ebrahim-Saraie, Mohammad Motamedifar
BACKGROUND: Over the past two decades, enterococci have emerged as an important agent responsible for hospital acquired infection. Several virulence factors contribute to the adherence, colonization, evasion of the host immune response, and pathogenicity and severity of the infection. Enterococcus faecalis is the most common and virulent species causing infections in hospitalized patients. The aim of the present study was to examine the prevalence of genes encoding virulence factors and antimicrobial resistance patterns of E...
March 2017: Infection & Chemotherapy
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