keyword
MENU ▼
Read by QxMD icon Read
search

Diabetic retinopathy renin angiotensin

keyword
https://www.readbyqxmd.com/read/28758590/renin-angiotensin-system-in-diabetes
#1
Michael Bader, Johannes Rein
The renin-angiotensin system (RAS) has two different axes, the classical one with the effector peptide angiotensin II and the new one with the effector peptide angiotensin (1-7). Both peptides have been shown to be involved in the pathogenesis of diabetes mellitus and its consequences, nephropathy, retinopathy and cardiomyopathy in animal models and patients. Angiotensin II acts mostly in a deleterious fashion and angiotensin (1-7) in a protective fashion. In this review we summarize the knowledge about the role of the different RAS axes in diabetes mellitus and the use of drugs interfering with the RAS in the therapy of the disease...
July 28, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28731289/current-status-of-achieving-blood-pressure-target-and-its-clinical-correlates-in-japanese-type-2-diabetes
#2
Hiroki Yokoyama, Shin-Ichi Araki, Koichi Kawai, Koichi Hirao, Yoshio Kurihara, Hiroaki Seino, Hiroshi Takamura, Hidekatsu Sugimoto, Akira Okada, Hiroshi Maegawa
AIMS/INTRODUCTION: To investigate the current status of achieved blood pressure levels in association with the number of antihypertensive drug classes as of 2013, and to explore the clinical correlates with achievement of target blood pressure in a large-scale cohort of Japanese subjects with type 2 diabetes. MATERIALS AND METHODS: A nationwide survey was conducted including 12,811 subjects with type 2 diabetes. Subjects were divided by achieved blood pressure, <130/80 or 140/90 mmHg, and the number of drug classes taken...
July 21, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28549900/four-decades-of-ocular-renin-angiotensin-and-kallikrein-kinin-systems-1977-2017
#3
REVIEW
Rajko Igić
This review offers a contemporary history of the renin-angiotensin (RAS) and kallikrein-kinin (KKS) systems with emphasis on how these complex systems affect the eye. It describes the types of communication (cross-talk) between the two systems and evaluates their potential role in the development of diabetic retinopathy, diabetic macular edema, age-related macular degeneration, glaucoma, and uveitis. In addition to detailing the important physiological actions of components of the RAS and KKS, possibilities are suggested for new therapeutic avenues in the treatment of common ocular diseases...
May 23, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28403787/role-of-tissue-renin-angiotensin-system-and-the-chymase-angiotensin-1-12-axis-in-the-pathogenesis-of-diabetic-retinopathy
#4
Mohammad Shamsul Ola, Abdullah S Alhomida, Carlos M Ferrario, Sarfaraz Ahmad
Diabetic retinopathy (DR) is a major diabetes complication and the leading cause for vision loss and blindness in the adult human population. Diabetes, being an endocrinological disorder dysregulates a number of hormonal systems including the renin angiotensin system (RAS), which thereby may damage both vascular and neuronal cells in the retina. Angiotensin II (Ang II), an active component of the RAS is increased in diabetic retina, and may play a significant role in neurovascular damage leading to the progression of DR...
2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28391624/nitric-oxide-in-the-pathophysiology-of-retinopathy-evidences-from-preclinical-and-clinical-researches
#5
REVIEW
Radka Opatrilova, Peter Kubatka, Martin Caprnda, Dietrich Büsselberg, Vladimir Krasnik, Pavol Vesely, Sandeep Saxena, Surabhi Ruia, Ioana Mozos, Luis Rodrigo, Peter Kruzliak, Katia Goncalves Dos Santos
Retinopathy is the leading cause of blindness and visual disability in working-aged people. The pathogenesis of retinopathy is an actual and still open query. Alterations contributing to oxidative and nitrosative stress, including elevated nitric oxide and superoxide production, changes in the expression of different isoforms of nitric oxide synthase or endogenous antioxidant system, have been implicated in the mechanisms how this ocular disease develops. In addition, it was documented that renin-angiotensin system has been implicated in the progression of retinopathy...
April 8, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28367520/therapeutic-targets-of-renin-angiotensin-system-in-ocular-disorders
#6
REVIEW
Rajesh Choudhary, Mandeep Singh Kapoor, Amrita Singh, Surendra H Bodakhe
PURPOSE: To review current literature on the renin-angiotensin system (RAS)-mediated pathogenic mechanisms and therapeutic targets in ocular diseases. METHODS: A comprehensive literature survey was performed on PubMed, Scopus, and Google Scholar databases published from 1977 to 2016. The search terms were a RAS, angiotensin, angiotensin receptor, prorenin, pro (renin) receptor, angiotensin converting enzyme inhibitor, angiotensin receptor blocker associated with ocular disorders like cataract, glaucoma, diabetic retinopathy (DR), macular degeneration, and uveitis...
March 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28363842/potential-of-angiotensin-ii-receptor-blockers-in-the-treatment-of-diabetic-retinopathy
#7
REVIEW
Tapan Behl, Anita Kotwani
Impairments in renin-angiotensin-aldosterone system during diabetes mellitus, leading to its dysfunction, have been known since a decade. Hyperglycemia induces several pathological alterations which upregulate this system, accounting for overexpression of its downstream signaling molecules, amongst which angiotensin II (Ang II) and aldosterone hold prime pathological notoriety. Although it is well known that elevated plasma levels of Ang II play a crucial role in the pathophysiology of type-II diabetic mellitus, by inducing and aggravating insulin resistance, it is not quite much known that it equally elevates the possibility/risk of development of diabetic complications...
May 1, 2017: Life Sciences
https://www.readbyqxmd.com/read/27951594/beneficial-effects-of-combined-at1-receptor-neprilysin-inhibition-arni-versus-at1-receptor-blockade-alone-in-the-diabetic-eye
#8
Tuhina Prasad, Lodi C W Roksnoer, Ping Zhu, Amrisha Verma, Yiming Li, Wendy W Batenburg, René de Vries, A H Jan Danser, Qiuhong Li
Purpose: Dysfunction of the renin-angiotensin system (RAS) contributes to pathogenesis of diabetic retinopathy (DR). Yet RAS blockers have only limited beneficial effects on progression of DR in clinical trials. The natriuretic peptide system offsets RAS, so that enhancing the activity of this system on top of RAS blockade might be beneficial. Neprilysin has an important role in the degradation of natriuretic peptides. Therefore, we hypothesize that dual angiotensin receptor-neprilysin inhibition (ARNI) may outperform angiotensin receptor blocker (ARB) in protection against DR...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27837397/from-arb-to-arni-in-cardiovascular-control
#9
REVIEW
Estrellita Uijl, Lodi C W Roksnoer, Ewout J Hoorn, A H Jan Danser
Coexistence of hypertension, diabetes mellitus and chronic kidney disease synergistically aggravates the risk of cardiovascular and renal morbidity and mortality. These high-risk, multi-morbid patient populations benefit less from currently available anti-hypertensive treatment. Simultaneous angiotensin II type 1 receptor blockade and neprilysin inhibition ('ARNI') with valsartan/sacubitril (LCZ696) might potentiate the beneficial effects of renin-angiotensin-aldosterone inhibition by reinforcing its endogenous counterbalance, the natriuretic peptide system...
December 2016: Current Hypertension Reports
https://www.readbyqxmd.com/read/27704165/the-teto-rat-as-a-new-translational-model-for-type-2-diabetic-retinopathy-by-inducible-insulin-receptor-knockdown
#10
Nadine Reichhart, Sergio Crespo-Garcia, Nadine Haase, Michaela Golic, Sergej Skosyrski, Anne Rübsam, Christina Herrspiegel, Norbert Kociok, Natalia Alenina, Michael Bader, Ralf Dechend, Olaf Strauss, Antonia M Joussen
AIMS/HYPOTHESIS: Although the renin-angiotensin system plays an important role in the progression of diabetic retinopathy, its influence therein has not been systematically evaluated. Here we test the suitability of a new translational model of diabetic retinopathy, the TetO rat, for addressing the role of angiotensin-II receptor 1 (AT1) blockade in experimental diabetic retinopathy. METHODS: Diabetes was induced by tetracycline-inducible small hairpin RNA (shRNA) knockdown of the insulin receptor in rats, generating TetO rats...
January 2017: Diabetologia
https://www.readbyqxmd.com/read/27695972/aliskiren-decreases-oxidative-stress-and-angiogenic-markers-in-retinal-pigment-epithelium-cells
#11
Sónia Simão, Daniela F Santos, Gabriela A Silva
There is growing evidence on the role of ocular renin-angiotensin system (RAS) in the development of diabetic retinopathy (DR), particularly due to the trigger of oxidative stress and angiogenesis. Despite this there is no effective RAS-based therapy in DR capable of preventing retinal damage induced by RAS activation. We recently described that retinal pigment epithelium (RPE) cells express the main components of the RAS. We here propose to investigate the role of glucose upon the retinal RAS and whether aliskiren, a direct renin inhibitor, protects RPE cells from angiogenesis and oxidative stress...
October 1, 2016: Angiogenesis
https://www.readbyqxmd.com/read/27528260/growth-factors-in-the-pathogenesis-of-retinal-neurodegeneration-in-diabetes-mellitus
#12
REVIEW
Ben-Skowronek Iwona
Neurodegeneration is an initial process in the development of diabetic retinopathy (DR). High quantities of glutamate, oxidative stress, induction of the renin-angiotensin system (RAS) and elevated levels of RAGE are crucial elements in the retinal neurodegeneration caused by diabetes mellitus. At least, there is emerging proof to indicate that the equilibrium between the neurotoxic and neuroprotective components will affect the state of the retinal neurons. Somatostatin (SST), pigment epithelium-derived factor (PEDF), and erythropoietin (Epo) are endogenous neuroprotective peptides that are decreased in the eye of diabetic persons and play an essential role in retinal homeostasis...
2016: Current Neuropharmacology
https://www.readbyqxmd.com/read/27508608/-op-1d-10-the-ckd273-urinary-proteomic-classifier-is-not-a-marker-of-generalised-vascular-disease-in-type-2-diabetic-patients-with-normal-renal-function
#13
G Currie, J Flynn, M Lindhardt, H Mischak, P Rossing, C Delles
OBJECTIVE: Microalbuminuria (MA) is a marker of diabetic nephropathy (DN) but also indicates subclinical inflammation and vascular disease, limiting its sensitivity and specificity for early prediction of DN in type 2 diabetes. A urinary proteomic classifier based on 273 peptides (CKD273) shows promise for early detection of DN; however, the influence of inflammation and subclinical vascular disease on CKD27 is unknown. DESIGN AND METHOD: To dissect the relationship between CKD273, vascular phenotypes and inflammation without the confounding influence of MA we studied 145 normoalbuminuric patients with Type 2 diabetes participating in the PRIORITY (Proteomic prediction and Renin angiotensin aldosterone system Inhibition prevention Of early diabetic nephRopathy In TYpe 2 diabetes with normoalbuminuria) trial...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27178803/adeno-associated-virus-overexpression-of-angiotensin-converting-enzyme-2-reverses-diabetic-retinopathy-in-type-1-diabetes-in-mice
#14
James M Dominguez, Ping Hu, Sergio Caballero, Leni Moldovan, Amrisha Verma, Gavin Y Oudit, Qiuhong Li, Maria B Grant
Angiotensin-converting enzyme (ACE)-2 is the primary enzyme of the vasoprotective axis of the renin angiotensin system that regulates the classic renin angiotensin system axis. We aimed to determine whether local retinal overexpression of adenoassociated virus (AAV)-ACE2 prevents or reverses diabetic retinopathy. Green fluorescent protein (GFP)-chimeric mice were generated to distinguish resident (retinal) from infiltrating bone marrow-derived inflammatory cells and were made diabetic using streptozotocin injections...
June 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27128219/angiogenesis-and-inflammation-crosstalk-in-diabetic-retinopathy
#15
REVIEW
Margarida Capitão, Raquel Soares
Diabetic retinopathy (DR) is one of the most prevalent microvascular complications of diabetes and one of the most frequent causes of blindness in active age. Etiopathogenesis behind this important complication is related to several biochemical, hemodynamic and endocrine mechanisms with a preponderant initial role assumed by polyol pathways, increment of growth factors, accumulation of advanced glycation end products (AGE), activation of protein kinase C (PKC), activation of the renin-angiotensin-aldosterone system (RAAS), and leukostasis...
November 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/26511783/quality-of-care-in-patients-with-diabetic-kidney-disease-in-asia-the-joint-asia-diabetes-evaluation-jade-registry
#16
A O Luk, X Li, Y Zhang, X Guo, W Jia, W Li, J Weng, W Yang, W B Chan, R Ozaki, C C Tsang, M Mukhopadhyay, A K Ojha, E G Hong, K H Yoon, L Sobrepena, R M Toledo, M Duran, W Sheu, T Q Do, T K Nguyen, R C Ma, A P Kong, C C Chow, P C Tong, W Y So, J C Chan
AIMS: Diabetic kidney disease independently predicts cardiovascular disease and premature death. We examined the burden of chronic kidney disease (CKD, defined as an estimated GFR < 60 ml/min/1.73 m(2) ) and quality of care in a cross-sectional survey of adults (age ≥ 18 years) with Type 2 diabetes across Asia. METHODS: The Joint Asia Diabetes Evaluation programme is a disease-management programme implemented using an electronic portal that systematically captures clinical characteristics of all patients enrolled...
September 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/26285470/-diabetic-nephropathy-as-a-cause-of-chronic-kidney-disease
#17
Ivan Kos, Ingrid Prkačin
Diabetic nephropathy is the leading cause of end-stage chronic kidney disease in most developed countries. Hyperglycemia, hypertension and genetic predisposition are the main risk factors for the development of diabetic nephropathy. Elevated serum lipids, smoking habits, and the amount and origin of dietary protein also seem to play a role as risk factors. Clinical picture includes a progressive increase in albuminuria, decline in glomerular filtration, hypertension, and a high risk of cardiovascular morbidity and mortality...
December 2014: Acta Medica Croatica: C̆asopis Hravatske Akademije Medicinskih Znanosti
https://www.readbyqxmd.com/read/26222724/ft011-a-novel-cardiorenal-protective-drug-reduces-inflammation-gliosis-and-vascular-injury-in-rats-with-diabetic-retinopathy
#18
Devy Deliyanti, Yuan Zhang, Fay Khong, David R Berka, David I Stapleton, Darren J Kelly, Jennifer L Wilkinson-Berka
Diabetic retinopathy features inflammation as well as injury to glial cells and the microvasculature, which are influenced by hypertension and overactivity of the renin-angiotensin system. FT011 is an anti-inflammatory and anti-fibrotic agent that has been reported to attenuate organ damage in diabetic rats with cardiomyopathy and nephropathy. However, the potential therapeutic utility of FT011 for diabetic retinopathy has not been evaluated. We hypothesized that FT011 would attenuate retinopathy in diabetic Ren-2 rats, which exhibit hypertension due to an overactive extra-renal renin-angiotensin system...
2015: PloS One
https://www.readbyqxmd.com/read/25989912/non-traditional-systemic-treatments-for-diabetic-retinopathy-an-evidence-based-review
#19
REVIEW
Rafael Simó, Stefania Ballarini, José Cunha-Vaz, Linong Ji, Hermann Haller, Paul Zimmet, Tien Y Wong
The rapid escalation in the global prevalence diabetes, with more than 30% being afflicted with diabetic retinopathy (DR), means it is likely that associated vision-threatening conditions will also rise substantially. This means that new therapeutic approaches need to be found that go beyond the current standards of diabetic care, and which are effective in the early stages of the disease. In recent decades several new pharmacological agents have been investigated for their effectiveness in preventing the appearance and progression of DR or in reversing DR; some with limited success while others appear promising...
2015: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/25956467/therapeutic-uses-of-somatostatin-and-its-analogues-current-view-and-potential-applications
#20
REVIEW
Uma Rai, Thilini R Thrimawithana, Celine Valery, Simon A Young
Somatostatin is an endogeneous cyclic tetradecapeptide hormone that exerts multiple biological activities via five ubiquitously distributed receptor subtypes. Classified as a broad inhibitory neuropeptide, somatostatin has anti-secretory, anti-proliferative and anti-angiogenic effects. The clinical use of native somatostatin is limited by a very short half-life (1 to 3min) and the broad spectrum of biological responses. Thus stable, receptor-selective agonists have been developed. The majority of these somatostatin therapeutic agonists bind strongly to two of the five receptor subtypes, although recently an agonist of wider affinity has been introduced...
August 2015: Pharmacology & Therapeutics
keyword
keyword
60578
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"