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https://www.readbyqxmd.com/read/27754100/os-21-05-pivotal-role-of-heme-oxygenase-in-amelioration-by-nicotinamide-of-fetal-growth-restriction-associated-with-preeclampsia
#1
Hironobu Nakada, Tomofumi Fushima, Akiyo Sekimoto, Yuji Oe, Emiko Sato, Sadayoshi Ito, Hiroshi Sato, Nobuyuki Takahashi
OBJECTIVE: Preeclampsia (PE) is pregnancy-induced hypertension with proteinuria. It causes maternal death or fetal growth restriction (FGR). Although high BP can be managed with antihypertensive drugs, there is no effective treatment of FGR associated with PE. We have clarified that nicotinamide (Nam) alleviates PE-like condition and FGR induced by soluble fms-like tyrosine kinase-1 (sFlt-1) in mice. But the mechanism of how Nam works is unclear. Because Nam induces cytoprotective heme oxygenase 1 (HO-1), our aim is to clarify whether HO-1 contributes to therapeutic effect of Nam against FGR associated with PE...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643025/os-21-05-pivotal-role-of-heme-oxygenase-in-amelioration-by-nicotinamide-of-fetal-growth-restriction-associated-with-preeclampsia
#2
Hironobu Nakada, Tomofumi Fushima, Akiyo Sekimoto, Yuji Oe, Emiko Sato, Sadayoshi Ito, Hiroshi Sato, Nobuyuki Takahashi
OBJECTIVE: Preeclampsia (PE) is pregnancy-induced hypertension with proteinuria. It causes maternal death or fetal growth restriction (FGR). Although high BP can be managed with antihypertensive drugs, there is no effective treatment of FGR associated with PE. We have clarified that nicotinamide (Nam) alleviates PE-like condition and FGR induced by soluble fms-like tyrosine kinase-1 (sFlt-1) in mice. But the mechanism of how Nam works is unclear. Because Nam induces cytoprotective heme oxygenase 1 (HO-1), our aim is to clarify whether HO-1 contributes to therapeutic effect of Nam against FGR associated with PE...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/26952865/mtorc1-dependent-translation-of-collapsin-response-mediator-protein-2-drives-neuroadaptations-underlying-excessive-alcohol-drinking-behaviors
#3
F Liu, S Laguesse, R Legastelois, N Morisot, S Ben Hamida, D Ron
Mammalian target of rapamycin complex 1 (mTORC1) has an essential role in dendritic mRNA translation and participates in mechanisms underlying alcohol-drinking and reconsolidation of alcohol-related memories. Here, we report that excessive alcohol consumption increases the translation of downstream targets of mTORC1, including collapsin response mediator protein-2 (CRMP-2), in the nucleus accumbens (NAc) of rodents. We show that alcohol-mediated induction of CRMP-2 translation is mTORC1-dependent, leading to increased CRMP-2 protein levels...
March 8, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/26830482/proteomic-profiling-in-the-spinal-cord-and-sciatic-nerve-in-a-global-cerebral-ischemia-induced-mechanical-allodynia-mouse-model
#4
Shinichi Harada, Wataru Matsuura, Masaoki Takano, Shogo Tokuyama
Central post-stroke pain (CPSP) is one of the complications of cerebral ischemia and neuropathic pain syndrome. At present, there are few studies of pain in regions such as the spinal cord or sciatic nerve in cerebral ischemic animal models. To identify proteomic changes in the spinal cord and sciatic nerve in global cerebral ischemic model mice, in the present study we performed an investigation using proteomic methods. In a comparison between the intensity of protein spots obtained from a sham and that from a bilateral carotid artery occulusion (BCAO) in spinal cord and sciatic nerve, the levels of 10 (spinal cord) and 7 (sciatic nerve) protein spots were altered...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/26821224/early-ankle-mobilization-promotes-healing-in-a-rabbit-model-of-achilles-tendon-rupture
#5
Jiasharete Jielile, Batiza Asilehan, Aikeremu Wupuer, Bayixiati Qianman, Ayidaer Jialihasi, Wulanbai Tangkejie, Abudouheilil Maimaitiaili, Nuerai Shawutali, Aynaz Badelhan, Hadelebieke Niyazebieke, Adili Aizezi, Amuding Aisaiding, Yerzat Bakyt, Rakimbaiev Aibek, Jianati Wuerliebieke
The use of early mobilization of the ankle joint without orthosis in the treatment of Achilles tendon rupture has been advocated as the optimal management. The goal of this study was to compare outcomes in a postoperative rabbit model of Achilles tendon rupture between early mobilization and immobilized animals using a differential proteomics approach. In total, 135 rabbits were randomized into the control group (n=15), the postoperative cast immobilization (PCI) group (n=60), and the early mobilization (EM) group (n=60)...
January 2016: Orthopedics
https://www.readbyqxmd.com/read/26804001/anti-glycan-antibodies-halt-axon-regeneration-in-a-model-of-guillain-barr%C3%A3-syndrome-axonal-neuropathy-by-inducing-microtubule-disorganization-via-rhoa-rock-dependent-inactivation-of-crmp-2
#6
Victoria Rozés Salvador, Florencia Heredia, Andrés Berardo, Anabela Palandri, Jose Wojnacki, Ana L Vivinetto, Kazim A Sheikh, Alfredo Caceres, Pablo H H Lopez
Several reports have linked the presence of high titers of anti-Gg Abs with delayed recovery/poor prognosis in GBS. In most cases, failure to recover is associated with halted/deficient axon regeneration. Previous work identified that monoclonal and patient-derived anti-Gg Abs can act as inhibitory factors in an animal model of axon regeneration. Further studies using primary dorsal root ganglion neuron (DRGn) cultures demonstrated that anti-Gg Abs can inhibit neurite outgrowth by targeting gangliosides via activation of the small GTPase RhoA and its associated kinase (ROCK), a signaling pathway common to other established inhibitors of axon regeneration...
April 2016: Experimental Neurology
https://www.readbyqxmd.com/read/26789651/changes-of-synapses-in-experimental-autoimmune-encephalomyelitis-by-using-fasudil
#7
Jie-Zhong Yu, Chan Chen, Qiong Zhang, Yong-Fei Zhao, Ling Feng, Hai-Fei Zhang, Jian Meng, Cun-Gen Ma, Bao-Guo Xiao
The ROCK signaling pathway is involved in numerous fundamental cellular functions such as cell migration, apoptosis, inflammatory responses, and neurite outgrowth. Previous studies demonstrate that Fasudil exhibited therapeutic potential of experimental autoimmune encephalomyelitis (EAE) possibly through immune-modulation and anti-inflammation. In this study, we observed the effect of Fasudil on synaptic protection of EAE mice. Fasudil ameliorated the clinical severity of EAE and inhibited Rho kinase (ROCK), especially ROCK II, in brain and spinal cord of EAE mice...
March 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/26480649/-the-involvement-of-crmp-2-on-axonal-and-dendrictic-injury-after-hypoxic-ischemic-brain-injury-in-neonatal-rat
#8
Tao Xiong, Hong-ju Chen, Yi Qu, De-zhi Mu
OBJECTIVE: To investigate the activity of collapsin response mediator protein 2 (CRMP-2) and its possible regulation for axonal and dendrictic injury under hypoxia-ischemia (HI). METHODS: Postnatal day 10 SD rats were suffered the right common carotid artery ligation and 8% mixture of oxygen and nitrogen hypoxia 2.5 h to produce HI model. The expression of total and phosphorylated CRMP-2 and amyloid precursor protein (APP) were detected by Western blot after HI...
July 2015: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/26446259/activation-of-m1-muscarinic-acetylcholine-receptor-induces-surface-transport-of-kcnq-channels-through-a-crmp-2-mediated-pathway
#9
Ling Jiang, Anastasia Kosenko, Clinton Yu, Lan Huang, Xuejun Li, Naoto Hoshi
Neuronal excitability is strictly regulated by various mechanisms, including modulation of ion channel activity and trafficking. Stimulation of m1 muscarinic acetylcholine receptor (also known as CHRM1) increases neuronal excitability by suppressing the M-current generated by the Kv7/KCNQ channel family. We found that m1 muscarinic acetylcholine receptor stimulation also triggers surface transport of KCNQ subunits. This receptor-induced surface transport was observed with KCNQ2 as well as KCNQ3 homomeric channels, but not with Kv3...
November 15, 2015: Journal of Cell Science
https://www.readbyqxmd.com/read/26389656/tax-and-semaphorin-4d-released-from-lymphocytes-infected-with-human-lymphotropic-virus-type-1-and-their-effect-on-neurite-growth
#10
Sebastián Quintremil, Carolina Alberti, Matías Rivera, Fernando Medina, Javier Puente, Luis Cartier, Eugenio Ramírez, Yuetsu Tanaka, M Antonieta Valenzuela
Human lymphotropic virus type 1 (HTLV-1) is a retrovirus causing HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a neurodegenerative central nervous system (CNS) axonopathy. This virus mainly infects CD4(+) T lymphocytes without evidence of neuronal infection. Viral Tax, secreted from infected lymphocytes infiltrated in the CNS, is proposed to alter intracellular pathways related to axonal cytoskeleton dynamics, producing neurological damage. Previous reports showed a higher proteolytic release of soluble Semaphorin 4D (sSEMA-4D) from CD4(+) T cells infected with HTLV-1...
January 2016: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/26173097/clinical-and-histological-features-of-small-cell-lung-cancer-paraneoplastic-inflammatory-uveitis
#11
Edward J Casswell, Edward Pringle, Caroline Thuang, Mike D Sanders, Elizabeth M Graham
PURPOSE: Paraneoplastic ocular inflammation can be associated with the autoantibody against collapsin response-mediator protein-5 (anti-CRMP-5). We describe the clinical and histological features of 2 rare cases of small cell lung carcinoma (SCLC) presenting with intraocular inflammation: the first was anti-CRMP-5 positive and the second preceded the auto-antibody's discovery but with remarkably similar features. The previously unreported retinal histology is described. METHODS: Case notes review...
October 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/26140283/erratum-encephalomyeloneuropathy-with-crmp-5-antibodies-in-a-patient-with-a-primary-mediastinal-serinoma
#12
(no author information available yet)
[This corrects the article on p. e82 in vol. 2, PMID: 25798447.].
August 2015: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/25912584/paroxysmal-atrial-fibrillation-in-myotonic-dystrophy-type-1-patients-p-wave-duration-and-dispersion-analysis
#13
V Russo, F Di Meo, A Rago, A A Papa, A Molino, M Mosella, L Politano, M G Russo, G Nigro
OBJECTIVE: Myotonic dystrophy type 1 (MD1) is characterized by cardiac involvement, in about 80% of case, that predominantly affects the conduction system. Aim of our study was to evaluate the P-wave duration and dispersion (PD) in MD1 patients underwent pacemaker implantation with conserved systolic and diastolic function. PATIENTS AND METHODS: We enrolled 60 MD1 patients (age 51.3 ± 5 years; 11 females) underwent dual chamber pacemaker implantation for various grade of atrioventricular (AV) block...
April 2015: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/25912583/glycosides-of-cistanche-improve-learning-and-memory-in-the-rat-model-of-vascular-dementia
#14
J Chen, S-N Zhou, Y-M Zhang, Y-L Feng, S Wang
OBJECTIVE: Glycosides of cistanche (GC) is extracted from Xin Jiang Cistanche, which is widely used as a Chinese herb. This study aims to evaluate the effects of GC on vascular dementia (VD). MATERIALS AND METHODS: The VD model was established by the ligature of the bilateral common carotid artery in adult Wistar rats, who received daily i. p. administration of saline, GC (10 mg/kg body weight/d, i.p.) or oxiracetam (450 mg/kg body weight/d, i.p) for 14 days. Morris Water Maze test valued cognitive performance of the rats...
April 2015: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/25721504/controlled-release-mitochondrial-protonophore-reverses-diabetes-and-steatohepatitis-in-rats
#15
Rachel J Perry, Dongyan Zhang, Xian-Man Zhang, James L Boyer, Gerald I Shulman
Nonalcoholic fatty liver disease (NAFLD) is a major factor in the pathogenesis of type 2 diabetes (T2D) and nonalcoholic steatohepatitis (NASH). The mitochondrial protonophore 2,4 dinitrophenol (DNP) has beneficial effects on NAFLD, insulin resistance, and obesity in preclinical models but is too toxic for clinical use. We developed a controlled-release oral formulation of DNP, called CRMP (controlled-release mitochondrial protonophore), that produces mild hepatic mitochondrial uncoupling. In rat models, CRMP reduced hypertriglyceridemia, insulin resistance, hepatic steatosis, and diabetes...
March 13, 2015: Science
https://www.readbyqxmd.com/read/25501601/the-mt2-receptor-stimulates-axonogenesis-and-enhances-synaptic-transmission-by-activating-akt-signaling
#16
D Liu, N Wei, H-Y Man, Y Lu, L-Q Zhu, J-Z Wang
The MT2 receptor is a principal type of G protein-coupled receptor that mainly mediates the effects of melatonin. Deficits of melatonin/MT2 signaling have been found in many neurological disorders, including Alzheimer's disease, the most common cause of dementia in the elderly, suggesting that preservation of the MT2 receptor may be beneficial to these neurological disorders. However, direct evidence linking the MT2 receptor to cognition-related synaptic plasticity remains to be established. Here, we report that the MT2 receptor, but not the MT1 receptor, is essential for axonogenesis both in vitro and in vivo...
April 2015: Cell Death and Differentiation
https://www.readbyqxmd.com/read/25494574/carbon-monoxide-and-nitric-oxide-interactions-in-magnocellular-neurosecretory-neurones-during-water-deprivation
#17
W L Reis, V C Biancardi, S Son, J Antunes-Rodrigues, J E Stern
Nitric oxide (NO) and carbon monoxide (CO) are diffusible gas messengers in the brain. Previously, we have shown their independent involvement in central fluid/electrolyte homeostasis control. In the present study, we investigated a possible functional interaction between NO/CO in the regulation of vasopressin (VP) and oxytocin (OT) magnocellular neurosecretory cells (MNCs) activity in euhydrated (EU) and dehydrated [48-h water-deprived (48WD)] rats. Using brain slices from EU and 48WD rats, we measured, by immunohistochemistry, the expression of neuronal NO synthase (nNOS, which synthesises NO) and haeme-oxygenase (HO-1, which synthesises CO) in the hypothalamic supraoptic nucleus (SON)...
February 2015: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/25486534/glycogen-synthase-kinase-3-protein-kinase-activity-is-frequently-elevated-in-human-non-small-cell-lung-carcinoma-and-supports-tumour-cell-proliferation
#18
COMPARATIVE STUDY
Emma E Vincent, Douglas J E Elder, Linda O'Flaherty, Olivier E Pardo, Piotr Dzien, Lois Phillips, Carys Morgan, Joya Pawade, Margaret T May, Muhammad Sohail, Martin R Hetzel, Michael J Seckl, Jeremy M Tavaré
BACKGROUND: Glycogen synthase kinase 3 (GSK3) is a central regulator of cellular metabolism, development and growth. GSK3 activity was thought to oppose tumourigenesis, yet recent studies indicate that it may support tumour growth in some cancer types including in non-small cell lung carcinoma (NSCLC). We examined the undefined role of GSK3 protein kinase activity in tissue from human NSCLC. METHODS: The expression and protein kinase activity of GSK3 was determined in 29 fresh frozen samples of human NSCLC and patient-matched normal lung tissue by quantitative immunoassay and western blotting for the phosphorylation of three distinct GSK3 substrates in situ (glycogen synthase, RelA and CRMP-2)...
2014: PloS One
https://www.readbyqxmd.com/read/25468908/glycogen-synthase-kinase-3%C3%AE-orchestrates-microtubule-remodeling-in-compensatory-glomerular-adaptation-to-podocyte-depletion
#19
Weiwei Xu, Yan Ge, Zhihong Liu, Rujun Gong
Reminiscent of neural repair, following podocyte depletion, remnant-surviving podocytes exhibit a considerable adaptive capacity to expand and cover the denuded renal glomerular basement membrane. Microtubules, one of the principal cytoskeletal components of podocyte major processes, play a crucial role in podocyte morphogenesis and podocyte process outgrowth, branching, and elongation. Here, we demonstrated that the microtubule-associated proteins Tau and collapsin response mediator protein (CRMP) 2, key regulators of microtubule dynamics, were abundantly expressed by glomerular podocytes in vivo and in vitro, interacted with glycogen synthase kinase (GSK)3β, and served as its putative substrates...
January 16, 2015: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/25371370/the-unc-6-netrin-receptors-unc-40-dcc-and-unc-5-inhibit-growth-cone-filopodial-protrusion-via-unc-73-trio-rac-like-gtpases-and-unc-33-crmp
#20
Adam D Norris, Lakshmi Sundararajan, Dyan E Morgan, Zachary J Roberts, Erik A Lundquist
UNC-6/Netrin is a conserved axon guidance cue that can mediate both attraction and repulsion. We previously discovered that attractive UNC-40/DCC receptor signaling stimulates growth cone filopodial protrusion and that repulsive UNC-40-UNC-5 heterodimers inhibit filopodial protrusion in C. elegans. Here, we identify cytoplasmic signaling molecules required for UNC-6-mediated inhibition of filopodial protrusion involved in axon repulsion. We show that the Rac-like GTPases CED-10 and MIG-2, the Rac GTP exchange factor UNC-73/Trio, UNC-44/Ankyrin and UNC-33/CRMP act in inhibitory UNC-6 signaling...
November 2014: Development
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