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https://www.readbyqxmd.com/read/29791811/the-putative-transient-receptor-potential-trp-channel-protein-encoded-by-the-orf19-4805-is-involved-in-cation-sensitivity-antifungal-tolerance-and-filamentation-in-candida-albicans
#1
Linghuo Jiang, Yi Yang
The ancient family of cation channels, transient receptor potential (TRP) channels, is highly conserved in eukaryotes and plays various physiological functions from sensation of ion homeostasis to reception of pain and vision. Calcium-permeable TRP channels have been identified from the plant Arabidopsis thaliana (AtCsc1) and the budding yeast Saccharomyces cerevisiae (ScCsc1), respectively. In this study, we have characterized the functions of the Csc1 homolog, the orf19.4805, in Candida albicans. The orf19...
May 23, 2018: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/29790647/creating-a-collaborative-care-curriculum-framework
#2
Bronwyn Maddock, Arunaz Kumar, Fiona Kent
BACKGROUND: A faculty-wide approach to curriculum design is required to ensure students within all health professional courses are provided with relevant interprofessional education opportunities across their course of study. Within the Faculty of Medicine, Nursing and Health Sciences at Monash University, Australia, a Collaborative Care Curriculum Framework was developed to detail the learning outcomes for collaborative care for pre-registration students. METHODS: A six-stage process was undertaken...
May 23, 2018: Clinical Teacher
https://www.readbyqxmd.com/read/29779747/art-energy-and-the-brain
#3
Robert Pepperell
Recent years have seen a growing interest among neuroscientists and vision scientists in art and aesthetics, exemplifying a more general trend toward interdisciplinary integration in the arts, humanities, and sciences. However, true art-science integration remains a distant prospect due to fundamental differences in outlook and approach between disciplines. I consider two great challenges for any project designed to explain the role of the brain in art appreciation. First, scientists and artists need to identify common ground, common questions, and a shared motivation for inquiry...
2018: Progress in Brain Research
https://www.readbyqxmd.com/read/29769056/report-on-an-international-workshop-on-kangaroo-mother-care-lessons-learned-and-a-vision-for-the-future
#4
Adriano Cattaneo, Adidja Amani, Nathalie Charpak, Socorro De Leon-Mendoza, Sarah Moxon, Somashekhar Nimbalkar, Giorgio Tamburlini, Julieta Villegas, Anne-Marie Bergh
BACKGROUND: Globally, complications of prematurity are the leading cause of death in children under five. Preterm infants who survive their first month of life are at greater risk for various diseases and impairments in infancy, childhood and later life, representing a heavy social and economic burden for families, communities and health and social systems. Kangaroo mother care (KMC) is recommended as a beneficial and effective intervention for improving short- and long-term preterm birth outcomes in low- and high-income settings...
May 16, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29762507/m-health-lessons-learned-by-m-experiences
#5
José Bravo, Ramón Hervás, Jesús Fontecha, Iván González
m-Health is an emerging area that is transforming how people take part in the control of their wellness condition. This vision is changing traditional health processes by discharging hospitals from the care of people. Important advantages of continuous monitoring can be reached but, in order to transform this vision into a reality, some factors need to be addressed. m-Health applications should be shared by patients and hospital staff to perform proper supervised health monitoring. Furthermore, the uses of smartphones for health purposes should be transformed to achieve the objectives of this vision...
May 15, 2018: Sensors
https://www.readbyqxmd.com/read/29743217/strategies-for-addressing-the-challenges-of-patient-centered-medical-home-implementation-lessons-from-oregon
#6
Sherril Gelmon, Nicole Bouranis, Billie Sandberg, Shauna Petchel
BACKGROUND: Patient-centered medical homes (PCMHs) are at the forefront of the transformation of primary care as part of health systems reform. Despite robust literature describing implementation challenges, few studies describe strategies being used to overcome these challenges. This article addresses this gap through observations of exemplary PCMHs in Oregon, where the Oregon Health Authority supports and recognizes Patient-Centered Primary Care Homes (PCPCH). METHODS: Twenty exemplary PCPCHs were selected using program scores, with considerations for diversity in clinic characteristics...
May 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29723499/visions-for-the-future-of-neuroscience
#7
(no author information available yet)
Neuroscience is a broad discipline that embraces technology at multiple scales to understand the brain and to develop potential therapies. Scientists share their perspectives on the evolution of neuroscience research and what excites them about the future prospects for the field.
May 2, 2018: Neuron
https://www.readbyqxmd.com/read/29723123/re-imagining-the-role-of-the-physiotherapist-when-managing-people-with-long-term-conditions
#8
Sandra Elaine Hartley
The rising prevalence of long-term conditions (LTCs) is placing increasing pressures on healthcare systems. With the future prospect that more individuals will experience multiple comorbidities, LTCs are becoming a growing concern. This article aims to discuss the challenges faced by and the opportunities afforded to physiotherapists when caring for people with LTCs. It highlights the complexity of managing people with LTCs and the demands faced by physiotherapists when working within a transitioning healthcare service that necessitates cost-effective yet, sustainable care...
May 3, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29708056/development-of-clinical-pharmacy-in-belgian-hospitals-through-pilot-projects-funded-by-the-government
#9
A Somers, A Spinewine, I Spriet, S Steurbaut, P Tulkens, J D Hecq, L Willems, H Robays, M Dhoore, H Yaras, I Vanden Bremt, M Haelterman
Objectives The goal is to develop clinical pharmacy in the Belgian hospitals to improve drug efficacy and to reduce drug-related problems. Methods From 2007 to 2014, financial support was provided by the Belgian federal government for the development of clinical pharmacy in Belgian hospitals. This project was guided by a national Advisory Working Group. Each funded hospital was obliged to describe yearly its clinical pharmacy activities. Results In 2007, 20 pharmacists were funded in 28 pilot hospitals; this number was doubled in 2009 to 40 pharmacists over 54 institutions, representing more than half of all acute Belgian hospitals...
April 30, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29704429/insights-into-optic-pathway-glioma-vision-loss-from-mouse-models-of-neurofibromatosis-type-1
#10
REVIEW
Morgan E Freret, David H Gutmann
Neurofibromatosis type 1 (NF1) is a common cancer predisposition syndrome caused by mutations in the NF1 gene. The NF1-encoded protein (neurofibromin) is an inhibitor of the oncoprotein RAS and controls cell growth and survival. Individuals with NF1 are prone to developing low-grade tumors of the optic nerves, chiasm, tracts, and radiations, termed optic pathway gliomas (OPGs), which can cause vision loss. A paucity of surgical tumor specimens and of patient-derived xenografts for investigative studies has limited our understanding of human NF1-associated OPG (NF1-OPG)...
April 28, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29700671/flubendiamide-affects-visual-and-locomotory-activities-of-drosophila-melanogaster-for-three-successive-generations-p-f-1-and-f-2
#11
Saurabh Sarkar, Arnab Roy, Sumedha Roy
Flubendiamide is widely used in agricultural fields to exterminate a broad spectrum of pests (lepidopteran insects) by disrupting their muscle function. The main objective of this study was to find the effects of flubendiamide on a non-target organism, Drosophila melanogaster (dipteran insect). In the present study, different sub-lethal concentrations of Flubendiamide caused a significant (P < 0.05) decrease in acetylcholinesterase activity and increase in cytochrome P450 activity in adult D. melanogaster...
April 26, 2018: Invertebrate Neuroscience: IN
https://www.readbyqxmd.com/read/29699427/promoting-a-culture-of-health-through-cross-sector-collaborations
#12
Grant R Martsolf, Jennifer Sloan, Antonia Villarruel, Diana Mason, Cheryl Sullivan
In this study, we explore the experiences of innovative nurses who have developed cross-sector collaborations toward promoting a culture of health, with the aim of identifying lessons that can inform similar efforts of other health care professionals. We used a mixed-methods approach based on data from both an online survey and telephone interviews. A majority of the participants had significant collaborations with health care providers and non-health care providers. Strong partners included mental health providers, specialists, and primary care providers on the health side, and for non-health partners, the strongest collaborations were with community leaders, research institutions, and local businesses...
April 1, 2018: Health Promotion Practice
https://www.readbyqxmd.com/read/29697748/visual-and-hearing-impairments-are-associated-with-cognitive-decline-in-older-people
#13
Asri Maharani, Piers Dawes, James Nazroo, Gindo Tampubolon, Neil Pendleton
Introduction: highly prevalagent hearing and vision sensory impairments among older people may contribute to the risk of cognitive decline and pathological impairments including dementia. This study aims to determine whether single and dual sensory impairment (hearing and/or vision) are independently associated with cognitive decline among older adults and to describe cognitive trajectories according to their impairment pattern. Material and methods: we used data from totals of 13,123, 11,417 and 21,265 respondents aged 50+ at baseline from the Health and Retirement Study (HRS), the English Longitudinal Study of Ageing (ELSA) and the Survey of Health, Ageing and Retirement in Europe (SHARE), respectively...
April 25, 2018: Age and Ageing
https://www.readbyqxmd.com/read/29697591/optimal-management-of-pigment-epithelial-detachments-in-eyes-with-neovascular-age-related-macular-degeneration
#14
Arshad M Khanani, David Eichenbaum, Patricio G Schlottmann, Lisa Tuomi, David Sarraf
PURPOSE: This review aimed to determine the optimal management of retinal pigment epithelial detachments (PEDs) in neovascular age-related macular degeneration (nAMD) based on review of available evidence in the literature. METHODS: A comprehensive literature review evaluates previous retrospective and prospective studies that assessed the treatment of PEDs in nAMD. RESULTS: Studies illustrated that anti-vascular endothelial growth factor (VEGF) therapy can be effective in eyes with PED secondary to nAMD...
April 24, 2018: Retina
https://www.readbyqxmd.com/read/29689817/the-state-of-phylogenetic-analysis-narrow-visions-and-simple-answers-examples-from-the-diptera-flies
#15
Art Borkent
The order Diptera is remarkably diverse, not only in species but in morphological variation in every life stage, making them excellent candidates for phylogenetic analysis. Such analysis has been hampered by methods that have severely restricted character state interpretation. Morphological-based phylogenies should be based on a deep understanding of the morphology, development and function of character states, and have extensive outgroup comparisons made to determine their polarity. Character states clearly vary in their value for determining phylogenetic relationships and this needs to be studied and utilized...
January 17, 2018: Zootaxa
https://www.readbyqxmd.com/read/29688354/fair-principles-and-the-iedb-short-term-improvements-and-a-long-term-vision-of-obo-foundry-mediated-machine-actionable-interoperability
#16
Randi Vita, James A Overton, Christopher J Mungall, Alessandro Sette, Bjoern Peters
The Immune Epitope Database (IEDB), at www.iedb.org, has the mission to make published experimental data relating to the recognition of immune epitopes easily available to the scientific public. By presenting curated data in a searchable database, we have liberated it from the tables and figures of journal articles, making it more accessible and usable by immunologists. Recently, the principles of Findability, Accessibility, Interoperability and Reusability have been formulated as goals that data repositories should meet to enhance the usefulness of their data holdings...
January 1, 2018: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/29687756/improvement-attributes-in-healthcare-implications-for-integrated-care
#17
Patrick John Harnett
Purpose Healthcare quality improvement is a key concern for policy makers, regulators, carers and service users. Despite a contemporary consensus among policy makers that integrated care represents a means to substantially improve service outcomes, progress has been slow. Difficulties achieving sustained improvement at scale imply that methods employed are not sufficient and that healthcare improvement attributes may be different when compared to prior reference domains. The purpose of this paper is to examine and synthesise key improvement attributes relevant to a complex healthcare change process, specifically integrated care...
April 16, 2018: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/29686733/towards-a-strategic-alignment-of-public-health-and-primary-care-practices-at-local-levels-the-case-of-severe-and-enduring-mental-illness
#18
Ricky Banarsee, Cornelius Kelly, Austen El-Osta, Paul Thomas, Chris Brophy
The rapidly increasing number of people who have long-term conditions requires a system of coordinated support for self-care throughout the NHS. A system to support self-care needs to be aligned to systems that support shared-care and community development, making it easier for the multidisciplinary teams who provide care to also help patients and populations to help themselves. Public health practitioners need to work closely with clinicians to achieve this. The best place to coordinate this partnership is a community-based coordinating hub, or local health community - a geographic area of about 50,000 population where different contributions to self-care can be aligned...
March 2018: London Journal of Primary Care
https://www.readbyqxmd.com/read/29683984/effects-of-progressive-addition-lens-wear-on-digital-work-in-pre-presbyopes
#19
Chea-Su Kee, Tsz Wing Leung, Ka-Hung Kan, Christie Hang-I Lam
SIGNIFICANCE: Growing popularity of handheld digital devices imposes significant challenges to our visual system and clinical management. This study aimed to determine the effects of lens design on parameters that may influence the refractive management of pre-presbyopic adult computer users. PURPOSE: To determine the effects of wearing conventional single-vision lenses (SVL) versus progressive addition lenses (PAL) on the working distance and refractive status...
April 20, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29678088/translating-ehealth-visions-from-strategy-to-practice-a-benefit-management-approach
#20
Sidsel Villumsen, Christian Nøhr, Arild Faxvaag
The municipalities and the Regional Health Authorities in Central Norway have been assigned a mandate to implement a shared electronic health record, Helseplattformen, reflecting the visions set out in the national eHealth white paper 'One Citizen - One Record'. This study identifies and describe anticipated benefit streams of clinical decision support in 'One Citizen - One Record' and the user requirement specification documents of Helseplattformen. This study found that the benefit stream of clinical decision support translates from the health policy visions stated in 'One Citizen - One Record' into Helseplattformen...
2018: Studies in Health Technology and Informatics
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