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https://www.readbyqxmd.com/read/27902638/the-pathophysiology-of-geographic-atrophy-secondary-to-age-related-macular-degeneration-and-the-complement-pathway-as-a-therapeutic-target
#1
David S Boyer, Ursula Schmidt-Erfurth, Menno van Lookeren Campagne, Erin C Henry, Christopher Brittain
PURPOSE: Geographic atrophy (GA) is an advanced, vision-threatening form of age-related macular degeneration (AMD) affecting approximately five million individuals worldwide. To date, there are no approved therapeutics for GA treatment; however, several are in clinical trials. This review focuses on the pathophysiology of GA, particularly the role of complement cascade dysregulation and emerging therapies targeting the complement cascade. METHODS: Primary literature search on PubMed for GA, complement cascade in age-related macular degeneration...
November 29, 2016: Retina
https://www.readbyqxmd.com/read/27894440/when-autistic-behavior-suggests-a-disease-other-than-classic-autism
#2
REVIEW
Mark D Simms
Most neurodevelopmental disorders are defined by their clinical symptoms and many disorders share common features. Recently there has been an increase in the number of children diagnosed with autism spectrum disorder, although concerns have been raised about the accuracy of the reported prevalence rates. This article reviews the essential features of autism spectrum disorder and describes other conditions that may include similar symptoms that may be misdiagnosed as autism spectrum disorder (primary communication disorders, anxiety disorders, attachment disorders, intellectual disability, vision and hearing impairment, and normal variations)...
February 2017: Pediatric Clinics of North America
https://www.readbyqxmd.com/read/27866832/roscoe-owen-brady-md-remembrances-of-co-investigators-and-colleagues
#3
REVIEW
Robert J Desnick, Norman W Barton, Scott Furbish, Gregory A Grabowski, Stefan Karlsson, Edwin H Kolodny, Jeffrey A Medin, Gary J Murray, Pramod K Mistry, Marc C Patterson, Raphael Schiffmann, Neal J Weinreb
To celebrate the research visions and accomplishments of the late Roscoe O. Brady (1923-2016), remembrance commentaries were requested from several of his postdoctoral research fellows and colleagues. These commentaries not only reflect on the accomplishments of Dr. Brady, but they also share some of the backstories and experiences working in the Brady laboratory. They provide insights and perspectives on Brady's research activities, and especially on his efforts to develop an effective treatment for patients with Type 1 Gaucher disease...
November 12, 2016: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/27856545/examining-the-role-of-leadership-in-an-undergraduate-biology-institutional-reform-initiative
#4
Rebecca L Matz, Sarah E Jardeleza
Undergraduate science, technology, engineering, and mathematics (STEM) education reform continues to be a national priority. We studied a reform process in undergraduate biology at a research-intensive university to explore what leadership issues arose in implementation of the initiative when characterized with a descriptive case study method. The data were drawn from transcripts of meetings that occurred over the first 2 years of the reform process. Two literature-based models of change were used as lenses through which to view the data...
2016: CBE Life Sciences Education
https://www.readbyqxmd.com/read/27854266/using-technology-bioinformatics-and-health-informatics-approaches-to-improve-learning-experiences-in-optometry-education-research-and-practice
#5
REVIEW
Vivek K Gupta, Veer B Gupta
Rapid advances in ocular diagnostic approaches and emerging links of pathological changes in the eye with systemic disorders have widened the scope of optometry as the front line of eye health care. Expanding professional requirements stipulate that optometry students get a meticulous training in relevant information and communication technologies (ICT) and various bioinformatics and health informatics software to meet current and future challenges. Greater incorporation of ICT approaches in optometry education can facilitate increased student engagement in shared learning experiences and improve collaborative learning...
November 15, 2016: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/27848001/visions-of-restoration-in-fire-adapted-forest-landscapes-lessons-from-the-collaborative-forest-landscape-restoration-program
#6
Lauren S Urgenson, Clare M Ryan, Charles B Halpern, Jonathan D Bakker, R Travis Belote, Jerry F Franklin, Ryan D Haugo, Cara R Nelson, Amy E M Waltz
Collaborative approaches to natural resource management are becoming increasingly common on public lands. Negotiating a shared vision for desired conditions is a fundamental task of collaboration and serves as a foundation for developing management objectives and monitoring strategies. We explore the complex socio-ecological processes involved in developing a shared vision for collaborative restoration of fire-adapted forest landscapes. To understand participant perspectives and experiences, we analyzed interviews with 86 respondents from six collaboratives in the western U...
November 15, 2016: Environmental Management
https://www.readbyqxmd.com/read/27830260/the-virtuous-circles-of-clinical-information-systems-a-modern-utopia
#7
P Degoulet
CONTEXT: Clinical information systems (CIS) are developed with the aim of improving both the efficiency and the quality of care. OBJECTIVE: This position paper is based on the hypothesis that such vision is partly a utopian view of the emerging eSociety. METHODS: Examples are drawn from 15 years of experience with the fully integrated Georges Pompidou University Hospital (HEGP) CIS and temporal data series extracted from the data warehouses of Assistance Publique - Hôpitaux de Paris (AP-HP) acute care hospitals which share the same administrative organization as HEGP...
November 10, 2016: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/27826750/an-international-position-paper-on-mother-infant-perinatal-mental-health-with-guidelines-for-clinical-practice
#8
Ian Brockington, Ruth Butterworth, Nine Glangeaud-Freudenthal
The purpose of this paper is to set out informal, provisional and comprehensive but concise guidelines for mother-infant (perinatal) mental health (psychiatry), as an area of specialisation. It is informal in the sense that the authors are clinicians and researchers from many different nations, who share a common goal and vision, speaking on their own behalf and not with the backing of any authority or society. It is provisional in the expectation that it can be improved by criticism and new research findings...
November 8, 2016: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/27824724/multiple-evanescent-white-dot-syndrome-with-central-visual-loss
#9
Gaetano R Barile, Sarah A Harmon
PURPOSE: To report the clinical case of a 64-year-old man who developed several features of multiple evanescent white dot syndrome (MEWDS) but with central visual loss that persisted because of significant structural macular disease. METHODS: A case report was generated by a review of the clinical course and imaging investigations of one patient, along with review of the literature. RESULTS: A 64-year-old man noted decreased vision in the right eye for 2 weeks, associated with a central scotoma with shimmering, gauze effect of the vision...
November 7, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27822297/community-based-system-dynamic-as-an-approach-for-understanding-and-acting-on-messy-problems-a-case-study-for-global-mental-health-intervention-in-afghanistan
#10
Jean-Francois Trani, Ellis Ballard, Parul Bakhshi, Peter Hovmand
BACKGROUND: Afghanistan lacks suitable specialized mental healthcare services despite high prevalence of severe mental health disorders which are aggravated by the conflict and numerous daily stressors. Recent studies have shown that Afghans with mental illness are not only deprived of care but are vulnerable in many other ways. Innovative participatory approaches to the design of mental healthcare policies and programs are needed in such challenging context. METHODS: We employed community based system dynamics to examine interactions between multiple factors and actors to examine the problem of persistently low service utilization for people with mental illness...
2016: Conflict and Health
https://www.readbyqxmd.com/read/27815550/the-role-of-extrafoveal-vision-in-source-code-comprehension
#11
Pavel A Orlov, Roman Bednarik
Understanding software engineers' behaviour plays a vital role in the software development industry. It also provides helpful guidelines for teaching and learning. In this article, we conduct a study of the extrafoveal vision and its role in information processing. This is a new perspective on source code comprehension. Despite its major importance, the extrafoveal vision has been largely ignored by previous studies. The available research has been focused entirely on the foveal information processing and the gaze fixation position...
November 4, 2016: Perception
https://www.readbyqxmd.com/read/27814971/gait-biomechanics-in-the-era-of-data-science
#12
Reed Ferber, Sean T Osis, Jennifer L Hicks, Scott L Delp
Data science has transformed fields such as computer vision and economics. The ability of modern data science methods to extract insights from large, complex, heterogeneous, and noisy datasets is beginning to provide a powerful complement to the traditional approaches of experimental motion capture and biomechanical modeling. The purpose of this article is to provide a perspective on how data science methods can be incorporated into our field to advance our understanding of gait biomechanics and improve treatment planning procedures...
October 27, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27808408/the-california-linkages-program-doorway-to-housing-support-for-child-welfare-involved-parents
#13
Amy D'Andrade, James David Simon, Danna Fabella, Lolita Castillo, Cesar Mejia, David Shuster
Housing instability can complicate parents' efforts to provide for their children. Child welfare service agencies have had difficulty adequately serving parents' housing needs due to limited and constrained funding streams. This article integrates the voices of four important stakeholders to illuminate how an innovative model of service system coordination called Linkages addresses housing needs for child welfare-involved parents eligible for public assistance. Facilitated by Linkages, these parents can receive supportive housing services through programs affiliated with the California public assistance program CalWORKs...
November 3, 2016: American Journal of Community Psychology
https://www.readbyqxmd.com/read/27806054/beyond-our-borders-public-resistance-to-global-genomic-data-sharing
#14
Mary A Majumder, Robert Cook-Deegan, Amy L McGuire
Prospects have never seemed better for a truly global approach to science to improve human health, with leaders of national initiatives laying out their vision of a worldwide network of related projects. An extensive literature addresses obstacles to global genomic data sharing, yet a series of public polls suggests that the scientific community may be overlooking a significant barrier: potential public resistance to data sharing across national borders. In several large United States surveys, university researchers in other countries were deemed the least acceptable group of data users, and a just-completed US survey found a marked increase in privacy and security concerns related to data access by non-US researchers...
November 2016: PLoS Biology
https://www.readbyqxmd.com/read/27803001/forest-and-landscape-restoration-toward-a-shared-vision-and-vocabulary
#15
Robin L Chazdon, Lars Laestadius
No abstract text is available yet for this article.
November 1, 2016: American Journal of Botany
https://www.readbyqxmd.com/read/27800257/peripheral-vasculitis-intermediate-uveitis-and-interferon-use-in-multiple-sclerosis
#16
Şeref Kinyas, Haluk Esgin
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. A 40-year-old female patient with a 12-year history of MS was admitted to our clinic with blurred vision and floaters in her right eye for about 1 month. Here, we share the findings and the management of intermediate uveitis and retinal periphlebitis in an MS case being treated with interferon beta-1a for 7 years.
January 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/27799902/localization-of-impaired-kinesthetic-processing-post-stroke
#17
Jeffrey M Kenzie, Jennifer A Semrau, Sonja E Findlater, Amy Y Yu, Jamsheed A Desai, Troy M Herter, Michael D Hill, Stephen H Scott, Sean P Dukelow
Kinesthesia is our sense of limb motion, and allows us to gauge the speed, direction, and amplitude of our movements. Over half of stroke survivors have significant impairments in kinesthesia, which leads to greatly reduced recovery and function in everyday activities. Despite the high reported incidence of kinesthetic deficits after stroke, very little is known about how damage beyond just primary somatosensory areas affects kinesthesia. Stroke provides an ideal model to examine structure-function relationships specific to kinesthetic processing, by comparing lesion location with behavioral impairment...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27799600/partnership-in-research-a-vehicle-for-reaching-higher-summits
#18
Isabelle Gélinas, Isabelle Gélinas
BACKGROUND: Partnerships in occupational therapy between practitioners and researchers are important to advance knowledge relevant to clinical practice and support evidence-based practice in the profession. PURPOSE: This Muriel Driver lecture discusses why we should support practitioners' engagement in research and examines essential conditions required for successful collaborative partnerships in research. KEY ISSUES: Collaborative partnerships can alleviate the challenges preventing practitioners from participating in research and ensure that research initiatives are more relevant to clinical practice...
October 2016: Canadian Journal of Occupational Therapy. Revue Canadienne D'ergothérapie
https://www.readbyqxmd.com/read/27798177/synaptic-contributions-to-receptive-field-structure-and-response-properties-in-the-rodent-lateral-geniculate-nucleus-of-the-thalamus
#19
Vandana Suresh, Ulaş M Çiftçioğlu, Xin Wang, Brittany M Lala, Kimberly R Ding, William A Smith, Friedrich T Sommer, Judith A Hirsch
: Comparative physiological and anatomical studies have greatly advanced our understanding of sensory systems. Many lines of evidence show that the murine lateral geniculate nucleus (LGN) has unique attributes, compared with other species such as cat and monkey. For example, in rodent, thalamic receptive field structure is markedly diverse, and many cells are sensitive to stimulus orientation and direction. To explore shared and different strategies of synaptic integration across species, we made whole-cell recordings in vivo from the murine LGN during the presentation of visual stimuli, analyzed the results with different computational approaches, and compared our findings with those from cat...
October 26, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27787443/combined-intravitreal-ranibizumab-and-oral-supplementation-with-docosahexaenoic-acid-and-antioxidants-for-diabetic-macular-edema-two-year-randomized-single-blind-controlled-trial-results
#20
María Lafuente, Lourdes Ortín, María Argente, José L Guindo, María D López-Bernal, Francisco J López-Román, María J García, Juan Carlos Domingo, Jerónimo Lajara
PURPOSE: To assess the 2-year effectiveness of intravitreal ranibizumab combined with a dietary supplement rich in docosahexaenoic acid (DHA) plus antioxidants in 62 patients with diabetic macular edema. METHODS: In a randomized single-blind controlled study, 33 subjects (42 eyes) received intravitreal ranibizumab alone and 29 (34 eyes) combined with DHA (1,050 mg/day). Monthly ranibizumab (0.5 mg) was given for the first 4 months followed by on as-needed treatment...
October 26, 2016: Retina
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