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https://www.readbyqxmd.com/read/28328872/the-role-of-the-iacuc-in-ensuring-research-reproducibility
#1
REVIEW
Jerald Silverman, James Macy, Patricia A Preisig
There is a "village" of people impacting research reproducibility, such as funding panels, the IACUC and its support staff, institutional leaders, investigators, veterinarians, animal facilities, and professional journals. IACUCs can contribute to research reproducibility by ensuring that reviews of animal use requests, program self-assessments and post-approval monitoring programs are sufficiently thorough, the animal model is appropriate for testing the hypothesis, animal care and use is conducted in a manner that is compliant with external and institutional requirements, and extraneous variables are minimized...
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28323747/supporting-a-youth-with-cerebellar-ataxia-into-adolescence
#2
Veronica Meneses, Zurisadai Gonzalez-Castillo, Veronica B Edgar, Marilyn Augustyn
Zoe, a 13-year-old white girl, presents as a new patient to your pediatric clinic with complaints of frequent emesis, anxiety, and learning problems, and previous diagnosis of cerebellar ataxia. Parents accompany Zoe and state, "it is really hard for her to go out, she gets sick and falls easily." She was born full term by vaginal delivery without complications. Given globally delayed milestones, she received early intervention services. Feeding problems began at infancy, including gastroesophageal reflux and aspiration pneumonia...
March 17, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28320313/retention-of-duplicated-long-wavelength-opsins-in-mosquito-lineages-by-positive-selection-and-differential-expression
#3
Gloria I Giraldo-Calderón, Michael J Zanis, Catherine A Hill
BACKGROUND: Opsins are light sensitive receptors associated with visual processes. Insects typically possess opsins that are stimulated by ultraviolet, short and long wavelength (LW) radiation. Six putative LW-sensitive opsins predicted in the yellow fever mosquito, Aedes aegypti and malaria mosquito, Anopheles gambiae, and eight in the southern house mosquito, Culex quinquefasciatus, suggest gene expansion in the Family Culicidae (mosquitoes) relative to other insects. Here we report the first detailed molecular and evolutionary analyses of LW opsins in three mosquito vectors, with a goal to understanding the molecular basis of opsin-mediated visual processes that could be exploited for mosquito control...
March 21, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28293182/visual-field-map-clusters-in-high-order-visual-processing-organization-of-v3a-v3b-and-a-new-cloverleaf-cluster-in-the-posterior-superior-temporal-sulcus
#4
Brian Barton, Alyssa A Brewer
The cortical hierarchy of the human visual system has been shown to be organized around retinal spatial coordinates throughout much of low- and mid-level visual processing. These regions contain visual field maps (VFMs) that each follows the organization of the retina, with neighboring aspects of the visual field processed in neighboring cortical locations. On a larger, macrostructural scale, groups of such sensory cortical field maps (CFMs) in both the visual and auditory systems are organized into roughly circular cloverleaf clusters...
2017: Frontiers in Integrative Neuroscience
https://www.readbyqxmd.com/read/28290933/leveraging-the-partnership-for-patients-initiative-to-improve-patient-safety-and-quality-within-the-military-health-system
#5
Heidi B King, Kimberly Kesling, Carmen Birk, Theodore Walker, Heather Taylor, Michael Datena, Brittany Burgess, Lyndsay Bower
INTRODUCTION: Partnership for Patients (PfP) was a national initiative sponsored by the Department of Health and Human Services, Centers for Medicare and Medicaid Services, to reduce preventable hospital acquired conditions (HACs) by 40% and readmissions (within 30 days) by 20%, by the end of 2013 (as compared to the baseline of CY2010). Along with partners across the nation, the Assistant Secretary of Defense for Health Affairs, Dr. Jonathan Woodson, pledged to support PfP in June 2011...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28277202/facilitative-components-of-collaborative-learning-a-review-of-nine-health-research-networks
#6
Lisa Leroy, Jessica Levin Rittner, Karin E Johnson, Jessie Gerteis, Therese Miller
OBJECTIVE: Collaborative research networks are increasingly used as an effective mechanism for accelerating knowledge transfer into policy and practice. This paper explored the characteristics and collaborative learning approaches of nine health research networks. DATA SOURCES/STUDY SETTING: Semi-structured interviews with representatives from eight diverse US health services research networks conducted between November 2012 and January 2013 and program evaluation data from a ninth...
February 2017: Healthcare Policy, Politiques de Santé
https://www.readbyqxmd.com/read/28267687/hypertension-s-3-dilemmas-and-3-solutions-pharmacology-of-the-kidney-in-hypertension
#7
William A Pettinger
The Hypertension Community has 3 conflicting dilemmas: a goal systolic pressure of 120 mm Hg or less (the SPRINT Trials), 40% of our 60,000,000 hypertensives still sustain blood pressures above 140/90 mm Hg, and our most potent antihypertensive drug minoxidil sits on the sidelines, imprisoned in the Food and Drug Administration's Black Box designation. My solutions to these dilemmas are: (1) review of the facts of our most potent antihypertensive drug minoxidil which is essentially free of toxicity, (2) treatment focus on the fundamental cause of high blood pressure, that is excess dietary sodium and, (3) prevention of, and/or reversal of, the fundamental mechanism of worsening hypertension, arteriolar hypertrophy...
March 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28263698/population-health-research-early-description-of-the-organizational-shift-toward-population-health-management-and-defining-a-vision-for-leadership
#8
Kristi L Caldararo, David B Nash
As health care delivery systems adapt to the changing marketplace, many struggle to define a clear strategy that will prove successful in managing the health of entire populations. The federal government continues to put increasing pressure on organizations to shift away from the traditional way of delivering episodic care and move toward managing populations as a whole-before, during, and after a patient presents in a health care facility. Private payers have begun to follow suit as risk-based payer contracts and bundled payment models become increasingly popular...
March 6, 2017: Population Health Management
https://www.readbyqxmd.com/read/28255837/is-the-2015-eye-care-service-delivery-profile-in-southeast-asia-closer-to-universal-eye-health-need
#9
Taraprasad Das, Peter Ackland, Marcelino Correia, Prut Hanutsaha, Palitha Mahipala, Phanindra B Nukella, Gopal P Pokharel, Abu Raihan, Gullapalli N Rao, Thulasiraj D Ravilla, Yudha D Sapkota, Gilbert Simanjuntak, Ngwang Tenzin, Ubeydulla Thoufeeq, Tin Win
PURPOSE: The year 2015 status of eye care service profile in Southeast Asia countries was compared with year 2010 data to determine the state of preparedness to achieve the World Health Organization global action plan 2019. METHODS: Information was collected from the International Agency for Prevention of Blindness country chairs and from the recent PubMed referenced articles. The data included the following: blindness and low vision prevalence, national eye health policy, eye health expenses, presence of international non-governmental organizations, density of eye health personnel, and the cataract surgical rate and coverage...
March 2, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28242738/neuronal-control-of-fixation-and-fixational-eye-movements
#10
REVIEW
Richard J Krauzlis, Laurent Goffart, Ziad M Hafed
Ocular fixation is a dynamic process that is actively controlled by many of the same brain structures involved in the control of eye movements, including the superior colliculus, cerebellum and reticular formation. In this article, we review several aspects of this active control. First, the decision to move the eyes not only depends on target-related signals from the peripheral visual field, but also on signals from the currently fixated target at the fovea, and involves mechanisms that are shared between saccades and smooth pursuit...
April 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28241508/accelerators-sparking-innovation-and-transdisciplinary-team-science-in-disparities-research
#11
Carol R Horowitz, Khader Shameer, Janice Gabrilove, Ashish Atreja, Peggy Shepard, Crispin N Goytia, Geoffrey W Smith, Joel Dudley, Rachel Manning, Nina A Bickell, Maida P Galvez
Development and implementation of effective, sustainable, and scalable interventions that advance equity could be propelled by innovative and inclusive partnerships. Readied catalytic frameworks that foster communication, collaboration, a shared vision, and transformative translational research across scientific and non-scientific divides are needed to foster rapid generation of novel solutions to address and ultimately eliminate disparities. To achieve this, we transformed and expanded a community-academic board into a translational science board with members from public, academic and private sectors...
February 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28223112/understanding-and-applying-the-concept-of-value-creation-in-radiology
#12
David B Larson, Daniel J Durand, Daniel S Siegal
The concept of value in radiology has been strongly advocated in recent years as a means of advancing patient care and decreasing waste. This article explores the concept of value creation in radiology and offers a framework for how radiology practices can create value according to the needs of their referring clinicians. Value only exists in the eyes of a customer. We propose that the primary purpose of diagnostic radiology is to answer clinical questions using medical imaging to help guide management of patient care...
February 17, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28222007/object-discovery-via-cohesion-measurement
#13
Guanjun Guo, Hanzi Wang, Wan-Lei Zhao, Yan Yan, Xuelong Li
Color and intensity are two important components in an image. Usually, groups of image pixels, which are similar in color or intensity, are an informative representation for an object. They are therefore particularly suitable for computer vision tasks, such as saliency detection and object proposal generation. However, image pixels, which share a similar real-world color, may be quite different since colors are often distorted by intensity. In this paper, we reinvestigate the affinity matrices originally used in image segmentation methods based on spectral clustering...
February 16, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28220677/toward-a-sociology-of-oceans
#14
John Hannigan
Despite covering around 70 percent of the earth's surface, the ocean has long been ignored by sociology or treated as merely an extension of land-based systems. Increasingly, however, oceans are assuming a higher profile, emerging both as a new resource frontier, a medium for geopolitical rivalry and conflict, and a unique and threatened ecological hot spot. In this article, I propose a new sociological specialty area, the "sociology of oceans" to be situated at the interface between environmental sociology and traditional maritime studies...
February 2017: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/28207958/shared-care-requires-a-shared-vision-communities-of-clinical-practice-in-a-primary-care-setting
#15
Jessica Young, Tony Egan, Chrystal Jaye, Martyn Williamson, Anna Askerud, Peter Raude, Maree Penese
AIMS AND OBJECTIVES: To understand how a vision of care is formed and shared by patients and the primary care professionals involved in their care. BACKGROUND: To achieve the best health outcomes, it is important for patients and those who care for them to have a mutual understanding about what is important to the patient in their everyday life and why, and what care is necessary to realise this vision. Shared or team care does not necessarily translate to a consistent and integrated approach to a patient's care...
February 16, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28193687/rainbow-enhancers-regulate-restrictive-transcription-in-teleost-green-red-and-blue-cones
#16
Wei Fang, Chuanyu Guo, Xiangyun Wei
Photoreceptor-specific transcription of individual genes collectively constitutes the transcriptional profile that orchestrates the structural and functional characteristics of each photoreceptor type. It is challenging, however, to study the transcriptional specificity of individual photoreceptor genes because each gene's distinct spatiotemporal transcription patterns are determined by the unique interactions between a specific set of transcription factors and the gene's own cis-regulatory elements (CREs), which remain unknown for most of the genes...
March 15, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28187277/where-is-the-future-of-drug-discovery-for-cancer
#17
(no author information available yet)
With both small molecules and biologics succeeding in trials and in the clinic, the scope of drug discovery in cancer is changing. We asked a group of researchers to share their visions for how to identify new targets and how to approach taming them.
February 9, 2017: Cell
https://www.readbyqxmd.com/read/28186068/technology-induced-errors-and-adverse-event-reporting-in-an-organizational-learning-perspective
#18
Line Dausel Vinther, Christian Møller Jensen, Ditte Meulengracht Hjel-Mager, Nicoline Lyhne, Christian Nøhr
This paper addresses the possibilities of evaluating technology-induced errors, through the utilization of experiences of the Danish adverse event reporting system. The learning loop in the adverse event reporting system is identified and analyzed, to examine which elements can be utilized to evaluate technologies. The empirical data was collected through interviews and a workshop with members of the nursing staff at a nursing home in Aalborg, Denmark. It was found that, the establishment of sustainable feedback learning loops depends on shared visions in the organization and how creating shared visions requires involvement and participation...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28186064/critical-success-factors-and-engagement-methodology-for-successful-project-delivery
#19
Darryl Tourond, Haley Moore, Nancy Kotani
TELUS Health will share its critical success factors and engagement methodology to successfully deliver a project on time, while meeting the client's vision.
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28178439/juvenile-idiopathic-arthritis-in-the-era-of-international-cooperation
#20
REVIEW
Yosef Uziel
Juvenile idiopathic arthritis (JIA) is the most common chronic disease of childhood. Improved understanding of its pathogenesis has led to international cooperation in clinical studies. Multicenter, international collaborations and research facilitate rapid enrollment of enough patients to enable a variety of studies, including those of epidemiology, diagnostic and classification criteria, genetic disease predisposition, pathogenesis, outcomes, and treatment protocols. In the last 20 years, the vision of the Pediatric Rheumatology International Trial Organization (PRINTO) has become a reality of worldwide collaboration in pediatric rheumatology research, including North American and European research groups...
January 30, 2017: Rambam Maimonides Medical Journal
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