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https://www.readbyqxmd.com/read/28651047/prioritization-of-contaminants-of-emerging-concern-in-wastewater-treatment-plant-discharges-using-chemical-gene-interactions-in-caged-fish
#1
Edward J Perkins, Tanwir Habib, Barbara L Escalon, Jenna E Cavallin, Linnea Thomas, Matthew Weberg, Megan N Hughes, Kathleen M Jensen, Michael D Kahl, Daniel L Villeneuve, Gerald T Ankley, Natalia Garcia-Reyero
We examined whether contaminants present in surface waters could be prioritized for further assessment by linking the presence of specific chemicals to gene expression changes in exposed fish. Fathead minnows were deployed in cages for 2, 4, or 8 days at three locations near two different wastewater treatment plant discharge sites in the Saint Louis Bay, Duluth, MN and one upstream reference site. The biological impact of 51 chemicals detected in the surface water of 133 targeted chemicals was determined using biochemical endpoints, exposure activity ratios for biological and estrogenic responses, known chemical:gene interactions from biological pathways and knowledge bases, and analysis of the co-variance of ovary gene expression with surface water chemistry...
June 26, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28650934/congenital-cytomegalovirus-infection-child-development-quality-of-life-and-impact-on-daily-life
#2
Marjolein J Korndewal, Anne Marie Oudesluys-Murphy, Aloys C M Kroes, Ann C T M Vossen, Hester E de Melker
BACKGROUND: Congenital cytomegalovirus infection (cCMV) is the most common congenital infection worldwide and can lead to long-term impairments such as developmental delay. It is currently unknown how this affects the daily life of children and their parents. METHODS: Children with cCMV were identified by testing stored dried blood spots of 31.484 five-year-old children born in 2008 in the Netherlands. Parents of 133 children with cCMV and 274 children without cCMV participated and filled in questionnaires on the child's development, the child's and parents' quality of life, care provided for the children, and consequences of cCMV on daily life...
June 23, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28650638/identification-and-structure-activity-relationships-of-novel-compounds-that-potentiate-the-activities-of-antibiotics-in-escherichia-coli
#3
Keith M Haynes, Narges Abdali, Varsha Jhawar, Helen I Zgurskaya, Jerry M Parks, Adam T Green, Jerome Yves Baudry, Valentin V Rybenkov, Jeremy C Smith, John K Walker
In Gram-negative bacteria, efflux pumps are able to prevent effective cellular concentrations from being achieved for a number of antibiotics. Small molecule adjuvants that act as efflux pump inhibitors (EPIs) have the potential to reinvigorate existing antibiotics that are currently ineffective due to efflux mechanisms. Through a combination of rigorous experimental screening and in silico virtual screening we recently identified novel classes of EPIs that interact with the membrane fusion protein AcrA, a critical component of the AcrAB-TolC efflux pump in E...
June 26, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28650633/two-photon-spectroscopy-of-a-series-of-platinum-acetylides-conformation-induced-ground-state-symmetry-breaking
#4
Thomas M Cooper, Joy E Haley, Douglas M Krein, Aaron R Burke, Jonathan E Slagle, Aleksandr Mikhailov, Aleksander Rebane
With the goal of elucidating electronic and conformational effects on structure-spectroscopic property relationships in platinum acetylides, we synthesized a series of nominally centrosymmetric chromophores trans-Pt(PBu3)2(CC-Phenyl-X)2, where X = diphenylamino(DPA), NH2, OCH3, t-Bu, CH3, H, F, benzothiazole(BTH), CF3, CN and NO2. We collected one- and two-photon absorption spectra and also performed DFT and TDDFT calculations on the ground and excited state properties of these compounds. The DFT calculations revealed facile rotation between the two ligands, suggesting that the compounds exhibit nonplanar ground state conformations in solution...
June 26, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28650577/time-dependent-trends-in-cardiovascular-adverse-events-during-follow-up-after-carotid-or-iliofemoral-endarterectomy
#5
I D van Koeverden, S T W van Haelst, S Haitjema, J-P P M de Vries, F L Moll, H M den Ruijter, I E Hoefer, G W Dalmeijer, G J de Borst, G Pasterkamp
BACKGROUND: Recent observations have suggested a decline in vulnerable carotid artery and iliofemoral atherosclerotic plaque characteristics over the past decade. The aim of this study was to determine whether, in the presence of clinically manifest carotid or peripheral artery disease, secondary adverse cardiovascular events decreased over this period. METHODS: Patients included in the Athero-Express biobank between 2003 and 2012 were analysed. During 3-year follow-up, composite cardiovascular endpoints were documented yearly, including: myocardial infarction, coronary interventions, stroke, peripheral interventions and cardiovascular death...
June 26, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28650557/association-between-metformin-prescription-and-growth-rates-of-abdominal-aortic-aneurysms
#6
J Golledge, J Moxon, J Pinchbeck, G Anderson, S Rowbotham, J Jenkins, M Bourke, B Bourke, A Dear, T Buckenham, R Jones, P E Norman
BACKGROUND: It has been suggested that diabetes medications, such as metformin, may have effects that inhibit abdominal aortic aneurysm (AAA) growth. The aim of this study was to examine the association of diabetes treatments with AAA growth in three patient cohorts. METHODS: AAA growth was studied using ultrasound surveillance in cohort 1, repeated CT in cohort 2 and more detailed repeat CT in cohort 3. Growth was estimated by the mean annual increase in maximum AAA diameter...
June 26, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28650475/division-site-selection-linked-to-inherited-cell-surface-wave-troughs-in-mycobacteria
#7
Haig A Eskandarian, Pascal D Odermatt, Joëlle X Y Ven, Mélanie T M Hannebelle, Adrian P Nievergelt, Neeraj Dhar, John D McKinney, Georg E Fantner
Cell division is tightly controlled in space and time to maintain cell size and ploidy within narrow bounds. In bacteria, the canonical Minicell (Min) and nucleoid occlusion (Noc) systems together ensure that division is restricted to midcell after completion of chromosome segregation(1). It is unknown how division site selection is controlled in bacteria that lack homologues of the Min and Noc proteins, including mycobacteria responsible for tuberculosis and other chronic infections(2). Here, we use correlated optical and atomic-force microscopy(3,4) to demonstrate that morphological landmarks (waveform troughs) on the undulating surface of mycobacterial cells correspond to future sites of cell division...
June 26, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28650437/antigen-capturing-nanoparticles-improve-the-abscopal-effect-and-cancer-immunotherapy
#8
Yuanzeng Min, Kyle C Roche, Shaomin Tian, Michael J Eblan, Karen P McKinnon, Joseph M Caster, Shengjie Chai, Laura E Herring, Longzhen Zhang, Tian Zhang, Joseph M DeSimone, Joel E Tepper, Benjamin G Vincent, Jonathan S Serody, Andrew Z Wang
Immunotherapy holds tremendous promise for improving cancer treatment. To administer radiotherapy with immunotherapy has been shown to improve immune responses and can elicit the 'abscopal effect'. Unfortunately, response rates for this strategy remain low. Herein we report an improved cancer immunotherapy approach that utilizes antigen-capturing nanoparticles (AC-NPs). We engineered several AC-NP formulations and demonstrated that the set of protein antigens captured by each AC-NP formulation is dependent on the NP surface properties...
June 26, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28650343/anthrax-toxin-receptor-1-is-the-cellular-receptor-for-seneca-valley-virus
#9
Linde A Miles, Laura N Burga, Eric E Gardner, Mihnea Bostina, John T Poirier, Charles M Rudin
Seneca Valley virus (SVV) is an oncolytic picornavirus with selective tropism for neuroendocrine cancers. It has shown promise as a cancer therapeutic in preclinical studies and early-phase clinical trials. Here, we have identified anthrax toxin receptor 1 (ANTXR1) as the receptor for SVV using genome-wide loss-of-function screens. ANTXR1 is necessary for permissivity in vitro and in vivo. However, robust SVV replication requires an additional innate immune defect. We found that SVV interacts directly and specifically with ANTXR1, that this interaction is required for SVV binding to permissive cells, and that ANTXR1 expression is necessary and sufficient for infection in cell lines with decreased expression of antiviral IFN genes at baseline...
June 26, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28650339/ilc2-modulated-t-cell-to-mdsc-balance-is-associated-with-bladder-cancer-recurrence
#10
Mathieu F Chevalier, Sara Trabanelli, Julien Racle, Bérengère Salomé, Valérie Cesson, Dalila Gharbi, Perrine Bohner, Sonia Domingos-Pereira, Florence Dartiguenave, Anne-Sophie Fritschi, Daniel E Speiser, Cyrill A Rentsch, David Gfeller, Patrice Jichlinski, Denise Nardelli-Haefliger, Camilla Jandus, Laurent Derré
Non-muscle-invasive bladder cancer (NMIBC) is a highly recurrent tumor despite intravesical immunotherapy instillation with the bacillus Calmette-Guérin (BCG) vaccine. In a prospective longitudinal study, we took advantage of BCG instillations, which increase local immune infiltration, to characterize immune cell populations in the urine of patients with NMIBC as a surrogate for the bladder tumor microenvironment. We observed an infiltration of neutrophils, T cells, monocytic myeloid-derived suppressor cells (M-MDSCs), and group 2 innate lymphoid cells (ILC2)...
June 26, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28650277/attenuated-post-exercise-heart-rate-recovery-in-patients-with-systemic-lupus-erythematosus-the-role-of-disease-severity-and-beta-blocker-treatment
#11
P Bienias, M Ciurzyński, A Chrzanowska, I Dudzik-Niewiadomska, K Irzyk, K Oleszek, A Kalińska-Bienias, B Kisiel, W Tłustochowicz, P Pruszczyk
Objective Sinus tachycardia is frequently reported in systemic lupus erythematosus (SLE), while there are limited data on post-exercise ability to slow heart rate (i.e. heart rate recovery, HRR) in this group of patients. Methods We studied consecutive 70 patients with SLE and 30 healthy controls. All examined individuals underwent detailed clinical examination, echocardiography, Holter monitoring with heart rate variability and treadmill stress test using Bruce's protocol. HRR values were calculated as the difference between maximum HR during exercise and HR at the first (HRR1) and third (HRR3) minute of rest...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28649841/elucidating-the-mechanisms-driving-the-ageing-of-porous-hollow-ptni-c-nanoparticles-by-the-means-of-coads-stripping
#12
Tristan Asset, Raphael Chattot, Jakub Drnec, Pierre Bordet, Nathalie Job, Frédéric Maillard, Laetitia Dubau
The oxygen reduction reaction (ORR) activity of Pt-alloy electrocatalysts depends on (i) strain/ligand effects induced by the non-noble metal (3d transition metal or a rare-Earth ele-ment) alloyed to Pt, (ii) the orientation of the catalytic surfaces and (iii) the density of struc-tural defects (ex. vacancies, voids, interconnections). These structural defects influence the 'generalized' coordination number of Pt atoms, the Pt-alloy lattice parameter and thus the adsorption strength of the ORR intermediates (O*, OH*, OOH*)...
June 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28649744/mannose-binding-lectin-deficient-donors-increase-the-risk-of-bacterial-infection-and-bacterial-infection-related-mortality-after-liver-transplantation
#13
J Lombardo, G Sanclemente, J Colmenero, M Español-Rego, M T Arias, P Ruiz, E Mauro, L Sastre, G Crespo, A Rimola, A Moreno, F Lozano, M Navasa
Mannose-binding lectin (MBL) is synthesized by the liver and binds to microbes. MBL2 gene polymorphisms produce intermediate/low/null- or normal-MBL serum levels (MBL-deficient or MBL-sufficient phenotypes, respectively). We aimed to evaluate the incidence and severity of infection, rejection and survival within 1 year after liver transplantation (LT) according to donor and recipient MBL2 gene polymorphisms. A repeated-event analysis for infection episodes (negative binomial regression, Andersen-Gill model) was performed in 240 LT...
June 26, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28649614/integrated-molecular-landscape-of-parkinson-s-disease
#14
C J H M Klemann, G J M Martens, M Sharma, M B Martens, O Isacson, T Gasser, J E Visser, G Poelmans
Parkinson's disease is caused by a complex interplay of genetic and environmental factors. Although a number of independent molecular pathways and processes have been associated with familial Parkinson's disease, a common mechanism underlying especially sporadic Parkinson's disease is still largely unknown. In order to gain further insight into the etiology of Parkinson's disease, we here conducted genetic network and literature analyses to integrate the top-ranked findings from thirteen published genome-wide association studies of Parkinson's disease (involving 13...
2017: NPJ Parkinson's Disease
https://www.readbyqxmd.com/read/28649577/in%C3%A2-vivo-murine-matured-human-cd3-cells-as-a-preclinical-model-for-t-cell-based-immunotherapies
#15
Kevin G Haworth, Christina Ironside, Zachary K Norgaard, Willimark M Obenza, Jennifer E Adair, Hans-Peter Kiem
Adoptive cellular immunotherapy is a promising and powerful method for the treatment of a broad range of malignant and infectious diseases. Although the concept of cellular immunotherapy was originally proposed in the 1990s, it has not seen successful clinical application until recent years. Despite significant progress in creating engineered receptors against both malignant and viral epitopes, no efficient preclinical animal models exist for rapidly testing and directly comparing these engineered receptors...
September 15, 2017: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/28649041/determination-of-the-vertical-profile-of-particle-number-concentration-adjacent-to-a-motorway-using-an-unmanned-aerial-vehicle
#16
T F Villa, E R Jayaratne, L F Gonzalez, L Morawska
A quantitative assessment of the vertical profile of traffic pollution, specifically particle number concentration (PNC), in an open space adjacent to a motorway was possible for the first time, to the knowledge of the authors, using an Unmanned Aerial Vehicle (UAV) system. Until now, traffic pollution has only been measured at ground level while the vertical distribution, is limited to studies conducted from buildings or fixed towers and balloons. This new UAV system demonstrated that the PNC sampled during the period form 10 a...
June 22, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28648948/randomized-phase-ii-study-comparing-prophylactic-cranial-irradiation-alone-to-prophylactic-cranial-irradiation-and-consolidative-extra-cranial-irradiation-for-extensive-disease-small-cell-lung-cancer-ed-sclc-nrg-oncology-rtog-0937
#17
Elizabeth M Gore, Chen Hu, Alexander Y Sun, Daniel F Grimm, Suresh S Ramalingam, Neal E Dunlap, Kristin A Higgins, Maria Werner-Wasik, Aaron M Allen, Puneeth Iyengar, Gregory M M Videtic, Russell K Hales, Ronald C McGarry, James J Urbanic, Anthony T Pu, Candice A Johnstone, Volker W Stieber, Rebecca Paulus, Jeffrey D Bradley
INTRODUCTION: RTOG-0937 is a randomized phase-II trial evaluating 1-year OS with PCI or PCI plus consolidative radiation therapy (cRT) to intra-thoracic disease and extracranial metastases for ED-SCLC. METHODS: Patients with 1-4 extracranial metastases were eligible after CR or PR to chemotherapy. Randomization was to PCI or PCI+cRT to the thorax and metastases. Original stratification included PR vs CR after chemotherapy and 1 vs 2-4 metastases; age < 65 vs > 65 was added after an observed imbalance...
June 22, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28648918/acoustic-and-elastic-properties-of-glycerol-in-oil-based-gel-phantoms
#18
Luciana C Cabrelli, Felipe W Grillo, Diego R T Sampaio, Antonio A O Carneiro, Theo Z Pavan
Phantoms are important tools for image quality control and medical training. Many phantom materials have been proposed for ultrasound; most of them use water as the solvent, but these materials have disadvantages such as dehydration and low temporal stability if not properly stored. To overcome these difficulties, copolymer-in-oil gel was proposed as an inert and stable material; however, speed of sound for these materials is still lower than what is described for most biological tissues. Here, we propose the glycerol dispersion in oil-based gels to modify the acoustic and elastic properties of copolymer-in-oil phantoms...
June 22, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28648855/decreasing-incidence-of-foot-ulcer-among-patients-with-type-1-and-type-2-diabetes-in-the-period-2001-2014
#19
A Rasmussen, T Almdal, A Anker Nielsen, K E Nielsen, M E Jørgensen, S Hangaard, V Siersma, P E Holstein
AIM: Diabetic foot ulcer (DFU) is a serious complication to diabetes. The aim was to study the incidence of first DFU among patients with type 1 (T1DM) and type 2 diabetes (T2DM), stratified according to etiology: neuropathic, neuro-ischemic or ischemic, over a period of 14years (2001-2014). METHODS: DFU incidence rates were calculated from electronic patient record data from patients with T1DM and complicated T2DM from a large specialized diabetes hospital with a multidisciplinary foot clinic in Denmark...
June 13, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28648301/associations-of-early-kidney-disease-with-brain-magnetic-resonance-imaging-and-cognitive-function-in-african-americans-with-type-2-diabetes-mellitus
#20
Barry I Freedman, Kaycee M Sink, Christina E Hugenschmidt, Timothy M Hughes, Jeff D Williamson, Christopher T Whitlow, Nicholette D Palmer, Michael E Miller, Laura C Lovato, Jianzhao Xu, S Carrie Smith, Lenore J Launer, Joshua I Barzilay, Robert M Cohen, Mark D Sullivan, R Nick Bryan, Benjamin C Wagner, Donald W Bowden, Joseph A Maldjian, Jasmin Divers
BACKGROUND: Relationships between early kidney disease, neurocognitive function, and brain anatomy are poorly defined in African Americans with type 2 diabetes mellitus (T2DM). STUDY DESIGN: Cross-sectional associations were assessed between cerebral anatomy and cognitive performance with estimated glomerular filtration rate (eGFR) and urine albumin-creatinine ratio (UACR) in African Americans with T2DM. SETTING & PARTICIPANTS: African Americans with cognitive testing and cerebral magnetic resonance imaging (MRI) in the African American-Diabetes Heart Study Memory in Diabetes (AA-DHS MIND; n=512; 480 with MRI) and Action to Control Cardiovascular Risk in Diabetes (ACCORD) MIND (n=484; 104 with MRI) studies...
June 22, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
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