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https://www.readbyqxmd.com/read/29793166/renoprotective-effect-of-the-isoflavonoid-biochanin-a-against-cisplatin-induced-acute-kidney-injury-in-mice-effect-on-inflammatory-burden-and-p53-apoptosis
#1
Faiha A Suliman, Dina M Khodeer, Afaf Ibrahiem, Eman T Mehanna, Mohamed K El-Kherbetawy, Hala M F Mohammad, Sawsan A Zaitone, Yasser M Moustafa
Cisplatin is a potent widely-used chemotherapeutics; however, its clinical use is associated with nephrotoxicity. Renoprotective approaches are being discovered to halt the tubular cell death due to inflammatory and apoptotic burdens. In the present study, the renoprotective effects of different doses of biochanin A (10, 20 or 40 mg/kg) in mice treated with a single injection of cisplatin (10 mg/kg) were reported. Cisplatin administration resulted in marked increases in serum creatinine and blood urea nitrogen...
May 21, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29793142/synthesis-of-aryl-pyrazole-via-suzuki-coupling-reaction-in-vitro-mushroom-tyrosinase-enzyme-inhibition-assay-and-in-silico-comparative-molecular-docking-analysis-with-kojic-acid
#2
Pervaiz Ali Channar, Aamer Saeed, Fayaz Ali Larik, Bakhtawar Batool, Saima Kalsoom, M M Hasan, Mauricio F Erben, Hesham R El-Seedi, Musrat Ali, Zaman Ashraf
Aryl pyrazoles are well recognized class of heterocyclic compounds found in several commercially available drugs. Owing to their significance in medicinal chemistry, in this current account we have synthesized a series of suitably substituted aryl pyrazole by employing Suzuki cross-coupling reaction. All compounds were evaluated for inhibition of mushroom tyrosinase enzyme both in vitro and in silico. Compound 3f (IC50  = 1.568 ± 0.01 µM) showed relatively better potential compared to reference kojic acid (IC50  = 16...
April 30, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29793063/progressive-right-ventricular-enlargement-due-to-pulmonary-regurgitation-clinical-characteristics-of-a-low-risk-group
#3
Majd A El-Harasis, Heidi M Connolly, William R Miranda, Muhammad Y Qureshi, Nandini Sharma, Mohamad Al-Otaibi, Christopher V DeSimone, Alexander Egbe
BACKGROUND: The optimal interval between serial cardiac magnetic resonance imaging (CMRI) scans for monitoring right ventricular (RV) enlargement in the setting of severe pulmonic valve regurgitation (PR) is unknown. The purposes of this study were to (1) determine the annual change in RV volume on serial CMRI scans and (2) identify the risk factors for rapid progression of RV enlargement. METHODS: A retrospective study of adults with postintervention native valve PR and ≥2 CMRI scans at Mayo Clinic Rochester from 2000 to 2015 was conducted...
April 26, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29793039/antimicrobial-resistance-in-the-context-of-the-syrian-conflict-drivers-before-and-after-the-onset-of-conflict-and-key-recommendations
#4
REVIEW
Aula Abbara, Timothy M Rawson, Nabil Karah, Wael El-Amin, James Hatcher, Bachir Tajaldin, Osman Dar, Omar Dewachi, Ghassan Abu Sitta, Bernt Eric Uhlin, Annie Sparrow
Current evidence describing antimicrobial resistance (AMR) in the context of the Syrian conflict is of poor quality and sparse in nature. In this paper we explore and report the major drivers of AMR that were present in Syria pre-conflict and those that have emerged since its onset in March 2011. Drivers which existed before the conflict included a lack of enforcement of existing legislation to regulate over the counter antibiotics and notification of communicable diseases. This contributed to a number of drivers of AMR after the onset of conflict which were also compounded by the exodus of trained staff, the increase in overcrowding and unsanitary conditions, the increase in injuries and economic sanctions limiting the availability of required laboratory medical materials and equipment...
May 21, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29792927/bacillus-subtilis-as-probiotic-candidate-for-red-sea-bream-growth-performance-oxidative-status-and-immune-response-traits
#5
Amr I Zaineldin, Sayed Hegazi, Shunsuke Koshio, Manabu Ishikawa, Abdulnasser Bakr, Abeer M S El-Keredy, Mahmoud A O Dawood, Serge Dossou, Weilong Wang, Zhang Yukun
The effects of dietary administration of Bacillus subtilis on the growth, digestive enzyme activity, blood chemistry, oxidative status and immune response of red sea bream (Pagrus major) were evaluated in the current study. Fish fed five different levels of B. subtilis at 0 (BS0), 1 × 104 (BS1), 1 × 106 (BS2), 1 × 108 (BS3) and 1 × 1010 (BS4) CFU kg-1 diet for 60 days. The obtained results showed that B. subtilis supplementation significantly improved growth performance (FBW, WG and SGR), feed utilization (FI, FCE, PER and PG) and whole-body protein content when compared to the control group (P < 0...
May 21, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29792888/oral-vitamin-a-coupled-valsartan-nanomedicine-high-hepatic-stellate-cell-receptors-accessibility-and-prolonged-enterohepatic-residence
#6
Nesrine S El-Mezayen, Wessam F El-Hadidy, Wessam M El-Refaie, Thanaa I Shalaby, Mahmoud M Khattab, Aiman S El-Khatib
So far, liver fibrosis still has no clinically-approved treatment. The loss of stored vitamin-A (VA ) in hepatic stellate cells (HSCs), the main regulators to hepatic fibrosis, can be applied as a mechanism for their targeting. Valsartan is a good candidate for this approach; it is a marketed oral-therapy with inverse- and partial-agonistic activity to the over-expressed angiotensin-II type1 receptor (AT1R) and depleted nuclear peroxisome proliferator-activated receptor-gamma (PPAR-γ), respectively, in activated HSCs...
May 21, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29792353/gastroretentive-raft-liquid-delivery-system-as-a-new-approach-to-release-extension-for-carrier-mediated-drug
#7
Samar M Abouelatta, Ahmed A Aboelwafa, Omaima N El-Gazayerly
Gabapentin (GBP), an antiepileptic and anti-neuropathic agent, suffers from short half-life (5-7 h), has narrow absorption window, and is absorbed via carrier-mediated mechanism resulting in frequent dosing, poor compliance, and poor bioavailability (<60%). Moreover, GBP is a freely water-soluble drug, thus it is considered a challenging candidate to be formulated as extended release dosage form. In this study, raft forming systems were investigated as a potential drug delivery system for prolonging gastric residence time of GBP...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29791874/fabrication-of-electrospun-poly-vinyl-alcohol-dextran-nanofibers-via-emulsion-process-as-drug-delivery-system-kinetics-and-in-vitro-release-study
#8
A Meera Moydeen, M Syed Ali Padusha, Eman F Aboelfetoh, Salem S Al-Deyab, Mohamed H El-Newehy
A green method was used for the fabrication of coaxial nanofibers for use in biomedical applications. Coaxial nanofiber mats were fabricated by emulsion electrospinning from poly(vinyl alcohol) (PVA) and Dextran sulfate (Dex) blends loaded with ciprofloxacin (Cipro) as a model drug dissolved in edible oil. The ratio of the PVA/Dex mixture was optimized and nanofibers were stabilized against disintegration in water by thermal treatment at 120 °C. The morphology of the prepared nanofibers was observed by scanning electron microscopy and the structure of the core-shell nanofibers was confirmed by transmission electron microscopy...
May 20, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29791342/solution-of-dispersion-relations-of-multilayer-optical-fibers-a-comprehensive-study
#9
Hesham A Okda, Ishac Kandas, Moustafa H Aly, M El Osairy
The exact solution of the modal dispersion relation of multilayer optical fibers is very critical and complicated, especially in the case of complex refractive indices of some layers added to the fiber. In this paper, a different methodology is proposed to solve the complex dispersion relations for cladding modes, based on the well-defined proper expressions of electromagnetic fields in the different layers of optical fibers. An optical fiber, coated by a dielectric nonlinear layer, is analyzed using the exact four-layer model, and the results obtained are compared with those analyzed in the literature based on the approximate three-layer model, where the effect of the coating layer is neglected when solving the dispersion relation...
May 10, 2018: Applied Optics
https://www.readbyqxmd.com/read/29791163/on-the-relationship-between-excited-state-lifetime-and-isomerization-quantum-yield-in-animal-rhodopsins-beyond-the-one-dimensional-landau-zener-model
#10
Mohsen M T El-Tahawy, Artur Nenov, Oliver Weingart, Massimo Olivucci, Marco Garavelli
We show that the speed of the chromophore photoisomerization of animal rhodopsins is not a relevant control knob for their light sensitivity. This result is at odd with the momentum-driven tunnelling rationale (i.e., assuming a one-dimensional Landau-Zener model for the decay: Zener, C. "Non-Adiabatic Crossing of Energy Levels", Proceedings of the Royal Society of London. Series A 1932, 137 (833), 696-702) holding that a faster nuclear motion through the conical intersection translates into a higher quantum yield and, thus, light sensitivity...
May 23, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29790897/six-cycles-of-r-chop-21-are-not-inferior-to-eight-cycles-for-treatment-of-diffuse-large-b-cell-lymphoma-a-nordic-lymphoma-group-population-based-study
#11
T Wästerlid, J L Biccler, P N Brown, M Bøgsted, G Enblad, J Mészáros Jørgensen, J H Christensen, B E Wahlin, K E Smedby, T C El-Galaly, M Jerkeman
No abstract text is available yet for this article.
May 22, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29790527/protective-activity-of-tovophyllin-a-a-xanthone-isolated-from-garcinia-mangostana-pericarps-against-acetaminophen-induced-liver-damage-role-of-nrf2-activation
#12
Sabrin R M Ibrahim, Dina S El-Agamy, Hossam M Abdallah, Nishat Ahmed, Mohamed A Elkablawy, Gamal A Mohamed
Garcinia mangostana L. (GM, family Guttiferae) is one of the most widely recognized tropical fruits. GM is a wealthy pool of xanthones that exhibit a wide range of bioactivities. Tovophyllin A (TA) separated from GM pericarps was tested for its efficacy to ameliorate acetaminophen (APAP)-induced liver injury. Mice were injected with a single dose of APAP with or without TA pretreatment. The protective effects of TA against APAP-induced liver damage were evident through amelioration of serum indices of hepatotoxicity and improvement of hepatic histopathologic lesions...
May 23, 2018: Food & Function
https://www.readbyqxmd.com/read/29788962/phenolics-from-barleria-cristata-var-alba-as-carcinogenesis-blockers-against-menadione-cytotoxicity-through-induction-and-protection-of-quinone-reductase
#13
Ali M El-Halawany, Hossam M Abdallah, Ahmed R Hamed, Hany Ezzat Khalil, Ameen M Almohammadi
BACKGROUND: There are increasing interests in natural compounds for cancer chemoprevention. Blocking agents represent an important class of chemopreventive compounds. They prevent carcinogens from undergoing metabolic activation and thereby suppressing their interaction with cellular macromolecular targets. METHODS: The effect of phenolic compounds isolated from Barleria cristata var. alba as chemopreventive agent was evaluated. The ethyl acetate fraction of B. cristata was subjected to different chromatographic techniques for isolation of its major phenolic compounds...
May 22, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29788895/synthesis-of-nucleosides-and-non-nucleosides-based-4-6-disubstituted-2-oxo-dihydropyridine-3-carbonitriles-as-antiviral-agents
#14
Tarek S Ibrahim, Hassan A El-Sayed, Maan T Khayat, Amany M M Al-Mahmoudy, Ahmed H Moustafa, Ayat K Saad El-Deen, Sherif A F Rostom, Siva S Panda
BACKGROUND: Viral diseases are considered main threats that face the humanity worldwide. The emergence of new viruses like influenza viruses emphasizes the significance of designing novel antiviral drugs. METHOD: The aim of this work is to synthesize a new set of nucleoside and non-nucleoside cyanopyridine, characterized and evaluated for their in vitro antiviral properties against various strains. CONCLUSION: More than compounds showed variable antiviral potential against a panel of eighteen DNA and RNA viruses...
May 22, 2018: Medicinal Chemistry
https://www.readbyqxmd.com/read/29788781/purines-and-triazolo-4-3-e-purines-containing-pyrazole-moiety-as-potential-anticancer-and-antioxidant-agents
#15
Omaima G Shaaban, Heba A Abd El Razik, Shams El-Dine A Shams El-Dine, Fawzia A Ashour, Alaa A El-Tombary, Ola S Afifi, Marwa M Abu-Serie
AIM: Targeting apoptosis regulators such as caspases aiming at inducing apoptosis is an attractive strategy in cancer therapy. MATERIALS & METHODS: 8-Substituted purine incorporating pyrazole moiety were designed, synthesized and evaluated for their anticancer and antioxidant activities. RESULTS: Compounds 7a and 8a displayed potent and selective anticancer activity against lung cancer A549 cell line with low cytotoxicity on peripheral blood mononuclear normal cells...
May 23, 2018: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29788543/a-new-glutathione-conjugate-of-the-pyrrolizidine-alkaloids-produced-by-human-cytosolic-enzyme-dependent-reactions-in-vitro
#16
Fashe Muluneh, Merja R Häkkinen, Rami El-Dairi, Markku Pasanen, Risto O Juvonen
RATIONALE: The toxic metabolites of pyrrolizidine alkaloids (PAs) are initially formed by cytochrome P450 mediated oxidation reactions and primarily eliminated as glutathione (GSH) conjugates. Although the reaction between the reactive metabolites and GSH can occur spontaneously, the role of the cytosolic enzymes in the process has not been studied. METHODS: The toxic metabolites of selected PAs (retrorsine, monocrotaline, senecionine, lasiocarpine, heliotrine or senkirkine) were generated by incubating them in 100 mM phosphate buffer pH 7...
May 22, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29788346/monitoring-serious-adverse-events-in-the-sierra-leone-trial-to-introduce-a-vaccine-against-ebola
#17
Olamide D Jarrett, Jane F Seward, Augustin E Fombah, Robert Lindblad, Mohamed I Jalloh, Jill El-Khorazaty, Peter Dawson, Deron Burton, Jane Zucker, Wendy Carr, Mohamed M Bah, Gibrilla F Deen, Peter M George, Faustine James, Durodami R Lisk, Dudley Pratt, James B W Russell, Jibao D Sandy, Patrick Turay, Mary J Hamel, Stephanie J Schrag, Robert E Walker, Mohamed Samai, Susan T Goldstein
ClinicalTrials.gov [NCT02378753] and Pan African Clinical Trials Registry [PACTR201502001037220].
May 18, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29788342/health-conditions-in-an-adult-population-in-sierra-leone-data-reported-from-the-sierra-leone-trial-to-introduce-a-vaccine-against-ebola-strive
#18
Augustin E Fombah, Susan T Goldstein, Olamide D Jarrett, Mohamed I Jalloh, Jill El-Khorazaty, Durodami Radcliffe Lisk, Jennifer Legardy-Williams, Dudley A Pratt, Peter M George, James B W Russell, Stephanie J Schrag, Peter Dawson, Gibrilla F Deen, Wendy Carr, Robert Lindblad, Faustine James, Mohamed M Bah, John F Yillia, Jibao D Sandy, Patrick E Turay, Muhammad-Abbas Conteh, Laurence Slutsker, Barbara E Mahon, Mohamed Samai, Jane F Seward
ClinicalTrials.gov [NCT02378753] and Pan African Clinical Trials Registry [PACTR201502001037220].
May 18, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29787786/preparation-of-99m-tc-levetiracetam-intranasal-microemulsion-as-the-first-radiotracer-for-spect-imaging-of-the-synaptic-vesicle-protein-sv2a
#19
Hassan M Rashed, Rehab N Shamma, Hanan A El-Sabagh
Selective receptors imaging using gamma emitting radiopharmaceuticals allows accurate diagnosis and follow up of many brain related disorders. Levetiracetam, a selective SV2A receptor antiepileptic, was successfully radiolabeled using 99m Tc. Different conditions affecting the labelling process were studied and optimum radiochemical yield of 89.8% was obtained. 99m Tc-levetiracetam was effectively formulated and characterized as microemulsion with particle size of 16.34 ± 5.58 nm and polydispersity index of 0...
May 19, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29787531/blunt-traumatic-scapular-fractures-are-associated-with-great-vessel-injuries-in-children
#20
Ibrahim Abd El-Shafy, Lisa M Rosen, Jose M Prince, Robert W Letton, Nelson G Rosen
BACKGROUND: Patients with stable blunt great vessel injury (GVI) can have poor outcomes if the injury is not identified early. With current pediatric trauma radiation reduction efforts these injuries may be missed. As a known association between scapular fracture and GVI exists in adult blunt trauma patients, we examined whether that same association existed in pediatric blunt trauma patients. METHODS: Bluntly injured patients under 18 years old were identified from 2012-2014 in the National Trauma Data Bank...
May 21, 2018: Journal of Trauma and Acute Care Surgery
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