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https://www.readbyqxmd.com/read/27911234/ventriculostomy-associated-hemorrhage-a-risk-assessment-by-radiographic-simulation
#1
Faith C Robertson, Muhammad M Abd-El-Barr, Srinivasan Mukundan, William B Gormley
OBJECTIVE Ventriculostomy entry sites are commonly selected by freehand estimation of Kocher's point or approximations from skull landmarks and a trajectory toward the ipsilateral frontal horn of the lateral ventricles. A recognized ventriculostomy complication is intracranial hemorrhage from cortical vessel damage; reported rates range from 1% to 41%. In this report, the authors assess hemorrhagic risk by simulating traditional ventriculostomy trajectories and using CT angiography (CTA) with venography (CTV) data to identify potential complications, specifically from cortical draining veins...
December 2, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27910712/development-of-a-nanogel-formulation-for-transdermal-delivery-of-tenoxicam-a-pharmacokinetic-pharmacodynamic-modeling-approach-for-quantitative-prediction-of-skin-absorption
#2
Mohammed H Elkomy, Shahira F El Menshawe, Hussein M Eid, Ahmed M A Ali
This study investigates potentials of solid lipid nanoparticles (SLN) based gel for transdermal delivery of tenoxicam (TNX) and describes a pharmacokinetics-pharmacodynamics (PK-PD) modeling approach for predicting concentration-time profile in skin. A 2(3) factorial design was adopted to study the effect of formulation factors on SLN properties and determine the optimal formulation. SLN-gel tolerability was investigated using rabbit skin irritation test. Its anti-inflammatory activity was assessed by carrageenan induced rat paw edema test...
December 2, 2016: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/27910417/new-numerical-simulation-method-to-calibrate-the-regular-hexagonal-nai-tl-detector-with-radioactive-point-sources-situated-non-axial
#3
Ayman Hamzawy, Dimitar N Grozdanov, Mohamed S Badawi, Fuad A Aliyev, Abouzeid A Thabet, Mahmoud I Abbas, Ivan N Ruskov, Ahmed M El-Khatib, Yuri N Kopatch, Mona M Gouda
Scintillation crystals are usually used for detection of energetic photons at room temperature in high energy and nuclear physics research, non-destructive analysis of materials testing, safeguards, nuclear treaty verification, geological exploration, and medical imaging. Therefore, new designs and construction of radioactive beam facilities are coming on-line with these science brunches. A good number of researchers are investigating the efficiency of the γ-ray detectors to improve the models and techniques used in order to deal with the most pressing problems in physics research today...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910092/management-of-atrial-fibrillation-in-elderly-adults
#4
Yaanik Desai, Mikhael F El-Chami, Angel R Leon, Faisal M Merchant
Driven in large part by the aging of the population and the increasing prevalence of cardiovascular comorbidities associated with atrial fibrillation (AF), there is a burgeoning epidemic of AF in elderly adults. Although there is a large body of literature to guide management of people with AF, elderly adults with AF are frequently underrepresented in clinical trials. This review provides a contemporary update on management of elderly adults with AF with a particular focus on the two main clinical challenges that AF poses: stroke risk reduction and control of symptoms...
December 2, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27909551/post-endoscopic-retrograde-cholangiopancreatography-pancreatitis-risk-factors-and-predictors-of-severity
#5
Ayman El Nakeeb, Ehab El Hanafy, Tarek Salah, Ehab Atef, Hosam Hamed, Ahmad M Sultan, Emad Hamdy, Mohamed Said, Ahmed A El Geidie, Tharwat Kandil, Mohamed El Shobari, Gamal El Ebidy
AIM: To detect risk factors for post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) and investigate the predictors of its severity. METHODS: This is a prospective cohort study of all patients who underwent ERCP. Pre-ERCP data, intraoperative data, and post-ERCP data were collected. RESULTS: The study population consisted of 996 patients. Their mean age at presentation was 58.42 (± 14.72) years, and there were 454 male and 442 female patients...
November 16, 2016: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27909538/pulmonary-vein-remodeling-following-atrial-fibrillation-ablation-implications-for-the-radiographic-diagnosis-of-pulmonary-vein-stenosis
#6
Faisal M Merchant Md, Mathew R Levy Bs, Shahriar Iravanian Md, Ramal M Weragoda Md, Edward C Clermont Md, Heval M Kelli Md, Robert L Eisner PhD, David Vadnais Md, Mikhael F El-Chami Md, Angel R Leon Md, David B Delurgio Md
Background: Pulmonary vein (PV) reverse remodeling has been recognized following atrial fibrillation (AF) ablation. However, the extent of physiologic reverse remodeling after AF ablation and the potential impact of reverse remodeling on the radiographic diagnosis of PV stenosis have not been well characterized. Methods: From January 2004 to February 2014, 186 patients underwent paired cardiac magnetic resonance imaging (MRI) to delineate PV orifice dimensions before and after (mean 109 ± 61 days) an initial AF ablation...
August 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27909203/lipid-changes-around-the-final-menstrual-period-predict-carotid-subclinical-disease-in-postmenopausal-women
#7
Karen A Matthews, Samar R El Khoudary, Maria M Brooks, Carol A Derby, Siobán D Harlow, Emma J M Barinas-Mitchell, Rebecca C Thurston
BACKGROUND AND PURPOSE: Atherogenic changes in lipids occur among women around the time of the natural menopause, that is, within 1 year of the final menstrual period (FMP). We investigated whether lipid changes around the FMP are related to carotid intima-media thickness, interadventitial diameter, and plaque in postmenopausal women. METHODS: A total of 863 natural postmenopausal women with no history of heart attack or stroke underwent carotid ultrasound scans at follow-up year 12 or 13 of the Study of Women's Health Across the Nation...
December 1, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27908686/effect-of-different-vitrification-solutions-and-cryodevices-on-viability-and-subsequent-development-of-buffalo-oocytes-vitrified-at-the-germinal-vesicle-gv-stage
#8
Amr S El-Shalofy, Adel R Moawad, Gamal M Darwish, Sayed T Ismail, Aly B A Badawy, Magdy R Badr
The cryopreservation of immature oocytes would generate a readily available, non-seasonal source of female gametes for research and reproduction. In domestic animals, the most promising results on oocyte cryopreservation have been reported in cattle, few studies have been conducted on buffalo. The aim of the present study was to compare the use of different vitrification solutions and various cryodevices on viability and developmental competence of buffalo oocytes vitrified at the germinal vesicle (GV) stage...
November 28, 2016: Cryobiology
https://www.readbyqxmd.com/read/27908621/radiotherapy-with-curative-intent-in-patients-with-early-stage-medically-inoperable-non-small-cell-lung-cancer-a-systematic-review
#9
REVIEW
Conrad B Falkson, Emily T Vella, Edward Yu, Medhat El-Mallah, Robert Mackenzie, Peter M Ellis, Yee C Ung
Patients with early-stage non-small-cell lung cancer (NSCLC) who are unable to undergo surgery can be offered radiation therapy (RT). Previously, conventional RT was offered; however, newer techniques such as stereotactic body RT (SBRT) have become available. The objective of the present systematic review was to investigate the effectiveness of RT with curative intent in patients with early-stage medically inoperable NSCLC. MEDLINE, EMBASE, and the Cochrane Library were searched for studies comparing stereotactic RT with curative intent compared with observation or other types of RT for early-stage, medically inoperable, NSCLC...
October 27, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/27908539/design-synthesis-molecular-docking-anti-proteus-mirabilis-and-urease-inhibition-of-new-fluoroquinolone-carboxylic-acid-derivatives
#10
Mohammed A A Abdullah, Gamal El-Din A A Abuo-Rahma, El-Shimaa M N Abdelhafez, Heba A Hassan, Rehab M Abd El-Baky
New hydroxamic acid, hydrazide and amide derivatives of ciprofloxacin in addition to their analogues of levofloxacin were prepared and identified by different spectroscopic techniques. Some of the prepared compounds revealed good activity against the urease splitting bacteria, Proteus mirabilis. The urease inhibitory activity was investigated using indophenol method. Most of the tested compounds showed better activity than the reference acetohydroxamic acid (AHA). The ciprofloxacin hydrazide derivative 3a and levofloxacin hydroxamic acid 7 experienced the highest activity (IC50=1...
November 9, 2016: Bioorganic Chemistry
https://www.readbyqxmd.com/read/27907836/implications-of-adopting-a-biodiversity-based-vulnerability-index-versus-a-shoreline-environmental-sensitivity-index-on-management-and-policy-planning-along-coastal-areas
#11
G Harik, I Alameddine, R Maroun, G Rachid, D Bruschi, D Astiaso Garcia, M El-Fadel
In this study, a multi-criteria index was developed to assess anthropogenic stressors along the Mediterranean coastline. The index aimed at geo-locating pollution hotspots for informed decision making related to coastal zone management. The index was integrated in a Geographical Information System based geodatabase implemented at several pilot areas along the Northern (Italy and France), Eastern (Lebanon), and Southern (Tunisia) Mediterranean coastlines. The generated stressor maps were coupled with a biodiversity richness index and an environmental sensitivity index to produce vulnerability maps that can form the basis for prioritizing management and mitigation interventions towards the identification of pollution hotspots and the promotion of sustainable coastal zone management...
November 28, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27906949/pulsed-compared-to-thermal-radiofrequency-to-the-medial-calcaneal-nerve-for-management-of-chronic-refractory-plantar-fasciitis-a-prospective-comparative-study
#12
Ayman M Osman, Dina H El-Hammady, Mohamed M Kotb
BACKGROUND: Radiofrequency (RF) treatment is a minimally invasive procedure that has been used for more than 3 decades in treating various chronic pain syndromes. Conventional (continuous) RF treatment occasionally results in worsening or even initiating a new type of pain. The use of pulsed radiofrequency (PRF), which has a non- or minimally neurodestructive neuromodulatory effect, serves as an alternative to conventional RF therapy in many medical situations. OBJECTIVES: To evaluate the effect of applying PRF for 6 minutes vs...
November 2016: Pain Physician
https://www.readbyqxmd.com/read/27906243/magnetically-controllable-silicon-microring-with-ferrofluid-cladding
#13
A El Amili, M C M M Souza, F Vallini, N C Frateschi, Y Fainman
We experimentally investigate the application of magnetic fluids (MFs) on integrated silicon photonics. Using a ferrofluid-clad silicon microring resonator, we demonstrate active control of resonances by applying an external magnetic field. Relatively high loaded quality factors on the order of 6000 are achieved, despite the optical losses introduced by the magnetic nanoparticles. We demonstrate resonance shifts of 185 pm in response to a 110 Oe strong magnetic field, corresponding to an overall refractive index change of -3...
December 1, 2016: Optics Letters
https://www.readbyqxmd.com/read/27906199/microduplication-of-the-arid1a-gene-causes-intellectual-disability-with-recognizable-syndromic-features
#14
Marie Bidart, Michèle El Atifi, Sarra Miladi, John Rendu, Véronique Satre, Pierre F Ray, Caroline Bosson, Françoise Devillard, Daphné Lehalle, Valérie Malan, Jeanne Amiel, Maria Antonietta Mencarelli, Margherita Baldassarri, Alessandra Renieri, Jill Clayton-Smith, Gaëlle Vieville, Julien Thevenon, Florence Amblard, François Berger, Pierre-Simon Jouk, Charles Coutton
PURPOSE: To determine whether duplication of the ARID1A gene is responsible for a new recognizable syndrome. METHODS: We describe four patients with a 1p36.11 microduplication involving ARID1A as identified by array-comparative genomic hybridization . We performed comparative transcriptomic analysis of patient-derived fibroblasts using RNA sequencing and evaluated the impact of ARID1A duplication on the cell cycle using fluorescence-activated cell sorting. Functional relationships between differentially expressed genes were investigated with ingenuity pathway analysis (IPA)...
December 1, 2016: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/27905175/racial-disparity-in-all-cause-mortality-among-hepatitis-c-virus-infected-individuals-in-a-general-us-population-nhanes-iii
#15
B Emmanuel, M D Shardell, L Tracy, S Kottilil, S S El-Kamary
There are few long-term nationally representative studies of all-cause mortality among those infected with hepatitis C virus (HCV). When an additional 5 years of data were made publicly available in 2015, the Third National Health and Nutrition Examination Survey Linked Mortality File became the longest nationally representative study in the United States. Our objective was to update the estimated HCV-associated all-cause mortality in the general US population and determine any differences by sex, age and race/ethnicity...
December 1, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27905159/the-interaction-of-sleep-and-amyloid-deposition-on-cognitive-performance
#16
Jennifer R V Molano, Catherine M Roe, Yo-El S Ju
Sleep difficulties are emerging as a risk factor for dementia. This study examined the effect of sleep and amyloid deposition on cognitive performance in cognitively normal adults. Sleep efficiency was determined by actigraphy. Cerebrospinal fluid Aβ42 levels <500 pg mL(-1) , indicating amyloid deposition, was present in 23 participants. Psychometric tests included the Free and Cued Selective Reminding Test, Trail Making Test A and B, Animal Fluency, Letter Number Sequencing, and the Mini Mental State Examination...
December 1, 2016: Journal of Sleep Research
https://www.readbyqxmd.com/read/27905024/potential-anti-genotoxic-effect-of-sodium-butyrate-to-modulate-induction-of-dna-damage-by-tamoxifen-citrate-in-rat-bone-marrow-cells
#17
Haidan M El-Shorbagy
Sodium butyrate (SB) is one of the histone deacetylase inhibitors (HDACi's) that is recently evidenced to have a prooxidant activity and an ability to reduce hydrogen peroxide-induced DNA damage. Since the majority of estrogen receptor positive breast cancer patients are treated with tamoxifen citrate (TC), which exerts well established oxidative and genotoxic effects, thus the basic objective of this study is to determine whether SB could ameliorate or curate tamoxifen citrate-induced oxidative DNA damage and genotoxic effect in vivo through up-regulation of some antioxidant enzymes...
November 30, 2016: Cytotechnology
https://www.readbyqxmd.com/read/27903182/single-session-gamma-knife-radiosurgery-for-optic-pathway-hypothalamic-gliomas
#18
Amr M N El-Shehaby, Wael A Reda, Khaled M Abdel Karim, Reem M Emad Eldin, Ahmed M Nabeel
OBJECTIVE Because of their critical and central location, it is deemed necessary to fractionate when considering irradiating optic pathway/hypothalamic gliomas. Stereotactic fractionated radiotherapy is considered safer when dealing with gliomas in this location. In this study, the safety and efficacy of single-session stereotactic radiosurgery for optic pathway/hypothalamic gliomas were reviewed. METHODS Between December 2004 and June 2014, 22 patients with optic pathway/hypothalamic gliomas were treated by single-session Gamma Knife radiosurgery...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27903118/frontal-dermoid-cyst-coexisting-with-suprasellar-craniopharyngioma-a-spectrum-of-ectodermally-derived-epithelial-lined-cystic-lesions
#19
Hussam Abou-Al-Shaar, Muhammad M Abd-El-Barr, Hasan A Zaidi, Eleanor Russell-Goldman, Rebecca D Folkerth, Edward R Laws, E Antonio Chiocca
There is a wide group of lesions that may exist in the sellar and suprasellar regions. Embryologically, there is varying evidence that many of these entities may in fact represent a continuum of pathology deriving from a common ectodermal origin. The authors report a case of a concomitant suprasellar craniopharyngioma invading the third ventricle with a concurrent frontal lobe cystic dermoid tumor. A 21-year-old man presented to the authors' service with a 3-day history of worsening headache, nausea, vomiting, and blurry vision...
December 2016: Neurosurgical Focus
https://www.readbyqxmd.com/read/27903065/predominance-and-geo-mapping-of-avian-influenza-h5n1-in-poultry-sectors-in-egypt
#20
Abdelsatar Arafa, Ihab El-Masry, Shereen Khoulosy, Mohammed K Hassan, Moussa Soliman, Olubunmi G Fasanmi, Folorunso O Fasina, Gwenaelle Dauphin, Juan Lubroth, Yilma M Jobre
Highly pathogenic avian influenza (HPAI) virus of the H5N1 subtype has been enzootic in the Egyptian poultry with significant human infections since 2008. This work evaluates the epidemiological and virological information from February 2006 to May 2015 in spatial and temporal terms. Only data with confirmed HPAI H5N1 sub-type were collected, and matched with the epidemiological data from various spatially and temporally-dispersed surveillances implemented between 2006 and 2015. Spatio-temporal analysis was conducted on a total of 3338 confirmed H5N1 HPAI poultry disease outbreaks and outputs described based on transmission patterns, poultry species, production types affected, trade, geographic and temporal distributions in Egypt...
November 28, 2016: Geospatial Health
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