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https://www.readbyqxmd.com/read/29145399/point-mutation-in-d8c-domain-of-tamm-horsfall-protein-uromodulin-in-transgenic-mice-causes-progressive-renal-damage-and-hyperuricemia
#1
Lijie Ma, Yan Liu, Nichole K Landry, Tarek M El-Achkar, John C Lieske, Xue-Ru Wu
Hereditary mutations in Tamm-Horsfall protein (THP/uromodulin) gene cause autosomal dominant kidney diseases characterized by juvenile-onset hyperuricemia, gout and progressive kidney failure, although the disease pathogenesis remains unclear. Here we show that targeted expression in transgenic mice of a mutation within the domain of 8 cysteines of THP in kidneys' thick ascending limb (TAL) caused unfolded protein response in younger (1-month old) mice and apoptosis in older (12-month old) mice. While the young mice had urine concentration defects and polyuria, such defects progressively reversed in the older mice to marked oliguria, highly concentrated urine, fibrotic kidneys and reduced creatinine clearance...
2017: PloS One
https://www.readbyqxmd.com/read/29145152/possible-role-of-arthrospira-platensis-in-reversing-oxidative-stress-mediated-liver-damage-in-rats-exposed-to-lead
#2
Samah R Khalil, Walaa M Elhady, Yaser H A Elewa, Noura E Abd El-Hameed, Sozan A Ali
Environmental pollutants, particularly metallic elements, mobilized and released into the environment, eventually accumulate in the food chain and thus pose a serious threat to human and animal health. In the present study, the role of Arthrospira (Spirulina platensis; SP) as a protector against oxidative stress-mediated liver damage induced by an exposure to lead acetate (LA; as a metallic pollutant) was assessed. To achieve this aim, rats were orally administered with 300 mg/kg bw SP for 15 days, before and concurrently with an intraperitoneal injection of 50 mg/kg bw LA (6 injections throughout 15 days)...
November 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29144972/building-bridges-through-science
#3
Thomas Lissek, Michelle Adams, John Adelman, Ehud Ahissar, Mohammed Akaaboune, Huda Akil, Mustafa al'Absi, Fazal Arain, Juan Carlos Arango-Lasprilla, Deniz Atasoy, Jesus Avila, Ashraf Badawi, Hilmar Bading, Abdul Mannan Baig, Jimena Baleriola, Carlos Belmonte, Ilaria Bertocchi, Heinrich Betz, Colin Blakemore, Olaf Blanke, Philipp Boehm-Sturm, Tobias Bonhoeffer, Paolo Bonifazi, Nils Brose, Patrizia Campolongo, Tansu Celikel, Cathy C Chang, Ta-Yuan Chang, Ami Citri, Hollis T Cline, Jesus M Cortes, Kathleen Cullen, Kellie Dean, José M Delgado-Garcia, Mathieu Desroches, John F Disterhoft, John E Dowling, Andreas Draguhn, Sherif F El-Khamisy, Abdeljabbar El Manira, S Ather Enam, Juan M Encinas, Asier Erramuzpe, José A Esteban, Isabel Fariñas, Edmond Fischer, Izumi Fukunaga, Iñigo Gabilondo, Detlev Ganten, Albert Gidon, Juan Carlos Gomez-Esteban, Paul Greengard, Valery Grinevich, Agnés Gruart, Roger Guillemin, Ahmad R Hariri, Bassem Hassan, Michael Häusser, Yasunori Hayashi, Natasha K Hussain, Adnan Abdul Jabbar, Mohamed Jaber, Reinhardt Jahn, Essam Mohammed Janahi, Mohamed Kabbaj, Helmut Kettenmann, Merel Kindt, Shira Knafo, Georg Köhr, Shoji Komai, Harm Krugers, Bernd Kuhn, Nouria Lakhdar Ghazal, Matthew E Larkum, Mickey London, Beat Lutz, Carlos Matute, Luis Martinez-Millan, Mouna Maroun, James McGaugh, Ahmed A Moustafa, Anwar Nasim, Klaus-Armin Nave, Erwin Neher, Karoly Nikolich, Tiago Outeiro, Lucy M Palmer, Olga Penagarikano, Isabel Perez-Otano, Donald W Pfaff, Bruno Poucet, Atta-Ur Rahman, Pedro Ramos-Cabrer, Ali Rashidy-Pour, Richard J Roberts, Serafim Rodrigues, Joshua R Sanes, Andreas T Schaefer, Menahem Segal, Idan Segev, Saad Shafqat, Nikhat Ahmed Siddiqui, Hermona Soreq, Eduardo Soriano-García, Rainer Spanagel, Rolf Sprengel, Greg Stuart, Thomas C Südhof, Jan Tønnesen, Mario Treviño, Basim M Uthman, J Craig Venter, Alexei Verkhratsky, Craig Weiss, Torsten N Wiesel, Emre Yaksi, Ofer Yizhar, Larry J Young, Paul Young, Nasser H Zawia, José L Zugaza, Mazahir T Hasan
Science is ideally suited to connect people from different cultures and thereby foster mutual understanding. To promote international life science collaboration, we have launched "The Science Bridge" initiative. Our current project focuses on partnership between Western and Middle Eastern neuroscience communities.
November 15, 2017: Neuron
https://www.readbyqxmd.com/read/29144965/role-of-serum-1-3%C3%AE-d-glucan-assay-in-early-diagnosis-of-invasive-fungal-infections-in-a-neonatal-intensive-care-unit
#4
Abd Elazeez Shabaan, Lobna Mahmoud Elbaz, Wafaa M El-Emshaty, Basma Shouman
OBJECTIVES: To study the microbiological pattern of late onset neonatal sepsis cultures and to assess the diagnostic performance of serum (1,3)-β-d-glucan level for early diagnosis of invasive fungemia in high-risk infants admitted to a neonatal intensive care unit. METHODS: A prospective multicenter clinical trial conducted on infants at high risk for invasive fungal infections, with suspected late onset sepsis, admitted to a neonatal intensive care unit at Mansoura University Children's Hospital and Mansoura General Hospital between March 2014 and February 2016...
November 13, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/29144424/synthesis-characterization-and-biological-activities-of-biopolymeric-schiff-bases-prepared-with-chitosan-and-salicylaldehydes-and-their-pd-ii-and-pt-ii-complexes
#5
Hellen Franciane Gonçalves Barbosa, Maha Attjioui, Ana Paula Garcia Ferreira, Edward Ralph Dockal, Nour Eddine El Gueddari, Bruno M Moerschbacher, Éder Tadeu Gomes Cavalheiro
In an attempt to enhance chitosan biological activities, biopolymeric Schiff bases of chitosan and different salicylaldehydes and their palladium(II) and platinum(II) complexes were synthesized and tested. The chemical structures of these derivatives were characterized using ¹H-NMR, FTIR spectroscopy and XPRD. Thermal analysis was done through TGA/DTG-DTA. Electronic absorption spectra and surface morphologies were analyzed by SEM-EDAX. Chitosan and its derivatives were evaluated for their in vitro antimicrobial activity against two common bacterial and fungal plant pathogens Pseudomonas syringae pv...
November 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29144015/elucidating-the-impact-of-chalcogen-content-on-the-photovoltaic-properties-of-oxychalcogenide-perovkskites-namo3-xqx-m-nb-ta-and-q-s-se-te
#6
Heesoo Park, Fahhad H Alharbi, Stefano Sanvito, Nouar Tabet, Fedwa El-Mellouhi
In the quest for non-toxic and stable perovskites for solar cells, we conduct a systematic study of the effect of chalcogen content in oxychalcogenide perovskite using density functional theory (DFT) and quasi-particle perturbation theory. We explore the changes in the electronic structure due to the substitution of O atoms in NaNbO 3 and NaTaO 3 perovskite structures with various chalcogen (S, Se, Te) at different concentrations. Interestingly, the introduction of the chalcogen atoms results in a drastic reduction of the electronic band gap, making some of them fall within the visible range of the solar spectrum...
November 16, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29143462/evaluation-of-immediate-implants-augmented-with-autogenous-bone-melatonin-composite-graft-in-the-esthetic-zone-a-randomized-controlled-trial
#7
Hala H A Hazzaa, Naglaa Sh El-Kilani, Shadia Abd-Elhameed Elsayed, Phoebe M Abd El Massieh
PURPOSE: To evaluate the clinical and radiographic outcomes following the application of autogenous bone (ABG)/melatonin composite graft around immediate implants in the esthetic zone compared to ABG alone. MATERIALS AND METHODS: Twenty-six patients with two nonrestorable anterior/premolar teeth were randomly classified into two equal groups. Dental implants were immediately inserted either with ABG (control group) or ABG/melatonin (test group). Outcome measures were peri-implant sulcus depth (PD), gingival index (GI), and wound healing scores...
November 16, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29142397/chemical-composition-antimicrobial-and-antitumor-potentiality-of-essential-oil-of-ferula-tingitana-l-apiaceae-grow-in-libya
#8
Waleed Elghwaji, Abeer Mohamed El-Sayed, Kadriya S El-Deeb, Aly M ElSayed
Background: Ferula tingitana L. (Apiaceae) has been considered to have abortive and menstruation-inducing properties. It used to treat sore throat, fever, indigestion, and pains. Objectives: The objective of this study is to establish the chemical composition of the essential oil of flower, leaves of F. tingitana, and to throw light on antimicrobial, cytotoxic activities of Libyan plant. Materials and Methods: The chemical composition of the essential oil of flower (0...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29141479/development-of-a-carboxymethyl-chitosan-functionalized-nanoemulsion-formulation-for-increasing-aqueous-solubility-stability-and-skin-permeability-of-astaxanthin-using-low-energy-method
#9
Liang Hong, Chuan-Li Zhou, Feng-Ping Chen, Dan Han, Chun-Yuan Wang, Jia-Xin Li, Zhe Chi, Chen-Guang Liu
In this research, firstly astaxanthin (ASX)-loaded nanoemulsions (NEs) were produced using a convenient low-energy emulsion phase inversion method. The optimised ASX-NEs were prepared in the presence of Cremophor(®) EL and Labrafil(®) M 1944 CS, with a surfactant-to-oil ratio of 4:6. The ASX-NE droplets were spherical with a mean droplet diameter below 100 nm and a small negative surface charge. The system was stable without alteration of mean droplet diameter for three months. Then, the ASX-NE was functionalised with carboxymethyl chitosan (CMCS) through direct CMCS (0...
November 15, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29141102/statistically-optimized-ceftriaxone-sodium-biotransformation-through-achromobacter-xylosoxidans-strain-cef6-an-unusual-insight-for-bioremediation
#10
Ahmed Anan, Khaled M Ghanem, Amira M Embaby, Ahmed Hussein, Moustafa Y El-Naggar
The present study underlines a unique promising approach toward efficient biotransformation of ceftriaxone sodium (Ceftx), a highly frequent prescribed cephalosporin antibiotic, by a newly bacterium namely Achromobacter xylosoxidans strain Cef6 isolated from Ceftx contaminated raw materials in pharmaceutical industries. A three step sequential statistical-mathematical approach (Plackett-Burman design [PBD], Central Composite Design [CCD], and ridge-canonical analyses) was anticipated to optimize the biotransformation process...
November 15, 2017: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/29141040/medical-therapy-versus-radiofrequency-endometrial-ablation-in-the-initial-treatment-of-heavy-menstrual-bleeding-itom-trial-a-clinical-and-economic-analysis
#11
Abimbola O Famuyide, Shannon K Laughlin-Tommaso, Sherif A Shazly, Kirsten Hall Long, Daniel M Breitkopf, Amy L Weaver, Michaela E McGree, Sherif A El-Nashar, Maureen A Lemens, Matthew R Hopkins
BACKGROUND: Radiofrequency endometrial ablation (REA) is currently a second line treatment in women with heavy menstrual bleeding (MHB) if medical therapy (MTP) is contraindicated or unsatisfactory. Our objective is to compare the effectiveness and cost burden of MTP and REA in the initial treatment of HMB. METHODS: We performed a randomized trial at Mayo Clinic Rochester, Minnesota. The planned sample size was 60 patients per arm. A total of 67 women with HMB were randomly allocated to receive oral contraceptive pills (Nordette ®) or Naproxen (Naprosyn®) (n = 33) or REA (n = 34)...
2017: PloS One
https://www.readbyqxmd.com/read/29140940/rapid-infliximab-infusion-in-children-with-inflammatory-bowel-disease-a-multicenter-north-american-experience
#12
Wael El-Matary, Dana M H Dykes, Laura Bauman, Abdul Elkadri, Matthew W Carroll, Marisa R Izaguirre, Jennifer deBruyn, Charles M Samson, Alisa Muniz Crim, Sabina Ali, Andrew Grossman
BACKGROUND: Infliximab (IFX) infusion may lead to development of anti-IFX antibodies, and subsequent infusion reactions (IRs). The safety of rapid IFX infusion administered over 60 minutes has been under-investigated in children with inflammatory bowel disease. In a multicenter study, the frequency and nature of rapid infusion-associated IRs were examined. METHODS: The medical records of all consecutive children with inflammatory bowel disease receiving rapid IFX infusions between January 2014 and December 2016 were reviewed...
December 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29140772/role-of-patient-coping-strategies-in-understanding-the-effects-of-early-palliative-care-on-quality-of-life-and-mood
#13
Joseph A Greer, Jamie M Jacobs, Areej El-Jawahri, Ryan D Nipp, Emily R Gallagher, William F Pirl, Elyse R Park, Alona Muzikansky, Juliet C Jacobsen, Vicki A Jackson, Jennifer S Temel
Purpose The early integration of oncology and palliative care (EIPC) improves quality of life (QOL) and mood for patients with advanced cancer. However, the mechanisms by which EIPC benefits these outcomes remain unclear. We therefore examined whether EIPC improved patients' coping strategies and if changes in coping accounted for intervention effects on QOL and depressive symptoms. Patients and Methods For this secondary analysis of an EIPC trial, we examined data from 350 patients with newly diagnosed incurable lung or GI cancer...
November 15, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29139614/human-dental-stem-cell-derived-transgene-free-ipscs-generate-functional-neurons-via-embryoid-body-mediated-and-direct-induction-methods
#14
Ikbale El Ayachi, Jun Zhang, Xiao-Ying Zou, Zongdong Yu, Wei Wei, Kristen M S O'Connell, George T-J Huang
Induced pluripotent stem cells (iPSCs) give rise to neural stem/progenitor cells (NSCs), serving as a good source for neural regeneration. Here, we established transgene-free (TF) iPSCs from dental stem cells (DSCs) and determined their capacity to differentiate into functional neurons in vitro. Generated TF iPSCs from stem cells of apical papilla (SCAP) and dental pulp stem cells (DPSCs) underwent two methods -- embryoid body (EB)-mediated and direct induction, to guide TF-DSC iPSCs along with H9 or H9 Syn-GFP (human embryonic stem cells) into functional neurons in vitro...
November 15, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29139589/severe-fasting-hypoglycemia-in-a-child-after-total-pancreatectomy-with-islet-autotransplantation
#15
Jacob M Redel, Jaimie D Nathan, Maisam Abu-El-Haija, Tom K Lin, Joseph J Palermo, Deborah A Elder
TPIAT is an increasingly utilized treatment option for select children with CP. Post-TPIAT fasting hypoglycemia, unrelated to exogenous insulin, is a complication recently reported in adults. This phenomenon has not been described in children. We review a case of severe fasting hypoglycemia in an adolescent female occurring 10 months post-TPIAT. A 12-year-old girl underwent TPIAT for CP. Ten months postoperatively she developed recurrent hypoglycemia on a total daily insulin dose of 0.03 units/kg. Consequently, insulin therapy was discontinued...
November 15, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/29139305/development-of-optimized-self-nanoemulsifying-lyophilized-tablets-snelts-to-improve-finasteride-clinical-pharmacokinetic-behavior
#16
Tarek A Ahmed, Khalid M El-Say, Khaled M Hosny, Bader M Aljaeid
OBJECTIVE: Preparation of an optimized finasteride (FSD) lyophilized tablets loaded with self-nanoemulsifying drug delivery system (SNEDDS). SIGNIFICANCE: Enhance FSD bioavailability in male pattern baldness and benign prostatic hyperplasia. METHODS: Two-step optimization was implemented to achieve the study goals. First; mixture design was used to develop an optimized SNEDDS through which the effect of cosurfactant number of carbon atoms on SNEDDS particle size and thermodynamic stability has been tested...
November 15, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29139296/differential-content-of-proteins-mrnas-and-mirnas-suggests-that-mdsc-and-their-exosomes-may-mediate-distinct-immune-suppressive-functions
#17
Lucia Geis-Asteggiante, Ashton T Belew, Virginia K Clements, Nathan J Edwards, Suzanne Ostrand-Rosenberg, Nagib M El-Sayed, Catherine Fenselau
Myeloid-derived suppressor cells (MDSC) are immature myeloid cells that accumulate in the circulation and the tumor microenvironment of most cancer patients. There, MDSC suppress both adaptive and innate immunity, hindering immunotherapies. The inflammatory milieu often present in cancers facilitates MDSC suppressive activity, causing aggressive tumor progression and metastasis. MDSC from tumor-bearing mice release exosomes, which carry biologically active proteins and mediate some of the immunosuppressive functions characteristic of MDSC...
November 15, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29138961/blastocystis-subtypes-isolated-from-irritable-bowel-syndrome-patients-and-co-infection-with-helicobacter-pylori
#18
Ayman A El-Badry, Wegdan M Abd El Wahab, Doaa A Hamdy, Alaa Aboud
Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disease presenting clinically by abdominal pain with alteration of bowel habits. Although IBS has uncertain etiology, chronic gut inflammation due to persistent exposure to an infectious agent including Blastocystis sp. was proposed. The aim of this study was to detect the prevalence of Blastocystis sp. subtype (ST) isolated from stool of IBS patients and to assess Blastocystis sp. and H. pylori co-infection in IBS patients from Beni-Suef Governorate, Egypt...
November 14, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29138079/genetic-structure-and-phenotypic-variation-of-anopheles-darlingi-in-northwest-colombia
#19
Mariano Altamiranda-Saavedra, Jan E Conn, Margarita M Correa
This study evaluated the influence of environmental heterogeneity on Anopheles darlingi genetic and morphometric traits at a microgeographic level. Specimens of An. darlingi collected from multiple municipalities in the Colombian malaria endemic region Urabá-Bajo Cauca and Alto Sinú (UCS) were analyzed using 13 microsatellite loci. Spatial genetic structure, population variation and wing geometric morphometric analyses were performed. Microsatellite results showed low genetic differentiation and high gene flow among populations; four highly admixed subpopulations were detected with no particular association to the municipalities...
November 11, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29136552/development-and-validation-of-modified-quechers-method-coupled-with-lc-ms-ms-for-simultaneous-determination-of-cymiazole-fipronil-coumaphos-fluvalinate-amitraz-and-its-metabolite-in-various-types-of-honey-and-royal-jelly
#20
Weijia Zheng, Jin-A Park, A M Abd El-Aty, Seong-Kwan Kim, Sang-Hyun Cho, Jeong-Min Choi, Hee Yi, Soo-Min Cho, Amer Ramadan, Ji Hoon Jeong, Jae-Han Shim, Ho-Chul Shin
Over the past few decades, honey products have been polluted by different contaminants, such as pesticides, which are widely applied in agriculture. In this work, a modified EN - quick, easy, cheap, effective, rugged, and safe (QuEChERS) extraction method was developed for the simultaneous quantification of pesticide residues, including cymiazole, fipronil, coumaphos, fluvalinate, amitraz, and its metabolite 2,4-dimethylaniline (2,4-DMA), in four types of honey (acacia, wild, chestnut, and manuka) and royal jelly...
November 8, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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