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https://www.readbyqxmd.com/read/28919795/type-2-diabetes-in-vietnam-a-cross-sectional-prevalence-based-cost-of-illness-study
#1
Nguyen Tu Dang Le, Luyen Dinh Pham, Trung Quang Vo
BACKGROUND: According to the International Diabetes Federation, total global health care expenditures for diabetes tripled between 2003 and 2013 because of increases in the number of people with diabetes as well as in the average expenditures per patient. This study aims to provide accurate and timely information about the economic impacts of type 2 diabetes mellitus (T2DM) in Vietnam. METHOD: The cost-of-illness estimates followed a prospective, prevalence-based approach from the societal perspective of T2DM with 392 selected diabetic patients who received treatment from a public hospital in Ho Chi Minh City, Vietnam, during the 2016 fiscal year...
2017: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/28912920/microalbuminuria-correlation-with-prevalence-and-severity-of-coronary-artery-disease-in-non-diabetics
#2
Pravin Kumar Jha, Tony Ete, Amit Malviya, Chandra Kumar Das, Swapan Kumar Saha, Dhanjit Nath, Manish Kapoor, Animesh Mishra
BACKGROUND: Previous studies have shown that microalbuminuria (MAU) is an independent risk factor for cardiovascular diseases in diabetics, hypertensive patients and in the general population. However, the correlation of MAU with the severity of coronary artery disease (CAD) in non-diabetic patients has not been addressed in detail. This study aimed to investigate the relationship between MAU and severity of angiographically confirmed CAD in non-diabetic patients. METHODS: This was a cross-sectional study, which included 90 non-diabetic patients with documented CAD by coronary angiography...
October 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28906531/red-cell-distribution-width-is-correlated-with-extensive-coronary-artery-disease-in-patients-with-diabetes-mellitus
#3
Atac Celik, Metin Karayakali, Fatih Altunkas, Kayihan Karaman, Arif Arisoy, Koksal Ceyhan, Hasan Kadi, Fatih Koc
INTRODUCTION: Previous studies have predicted an independent relationship between red cell distribution width (RDW) and the risk of death and cardiovascular events in patients with coronary artery disease (CAD). The aim of this study was to investigate the relationship between RDW and extensiveness of CAD in patients with diabetes mellitus (DM). METHODS: Two hundred and thirty-three diabetic patients who underwent coronary angiographies at our centre in 2010 were included in the study...
August 23, 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/28903348/nuclear-receptor-nr4a1-is-a-tumor-suppressor-down-regulated-in-triple-negative-breast-cancer
#4
Hongmei Wu, Jiong Bi, Yan Peng, Lei Huo, Xiaobin Yu, Zhihui Yang, Yunyun Zhou, Li Qin, Yixiang Xu, Lan Liao, Yang Xie, Orla M Conneely, Jos Jonkers, Jianming Xu
The nuclear receptor (NR) superfamily contains hormone-inducible transcription factors that regulate many physiological and pathological processes through regulating gene expression. NR4A1 is an NR family member that still does not have an identified endogenous ligand, and its role in cancer is also currently unclear and controversial. In this study, we aimed to define the expression profiles and specific role of NR4A1 in the highly malignant triple-negative breast cancer (TNBC), which still lacks available targeted therapies...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28900476/breast-cancer-in-angola-molecular-subtypes-a-first-glance
#5
Fernando Miguel, Lygia Vieira Lopes, Eduardo Ferreira, Emília Ribas, Alexis Fuentes Pelaez, Conceição Leal, Teresina Amaro, Paula Lopes, Cristina Mendes Santos, Carlos Lopes, Lúcio Lara Santos
PURPOSE: The aim of this study was to investigate the breast cancer (BC) molecular subtypes according to its surrogate immunohistochemistry (IHC) markers. We conducted a preliminary study, to correlate the clinical pathological profiles and molecular subtypes of breast cancer in Luanda, Angola. METHODS: From January 2011 to 30 December 2014, 140 consecutive cases of microscopically confirmed invasive breast carcinoma were classified regarding histology and IHC (ER, PR, HER2, and Ki-67)...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28898719/a-cost-effective-lc-ms-ms-method-for-identification-and-quantification-of-%C3%AE-amanitin-in-rat-plasma-application-to-toxicokinetic-study
#6
Chunlei Li, Fen Wei, Saqib Muhammad, Guangde Yang, Sicen Wang, Xinshe Liu
α-Amanitin is the main lethal component of amanita mushrooms, and data on its toxicokinetics are few. The aim of this study was to develop a sensitive and cost-effective method to identify α-amanitin and investigate its toxicokinetic parameters using liquid chromatography-triple quadrupole tandem mass spectrometry. The colchicine was used as the internal standard (IS). The compounds were extracted from plasma samples by protein precipitation with acetonitrile (containing 1% formic acid). The analysis was performed through multiple reactions monitoring...
September 5, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28894384/technology-that-achieves-the-triple-aim-an-economic-analysis-of-the-brainpath%C3%A2-approach-in-neurosurgery
#7
Sidney P Norton, Evan M Dickerson, Charles G Kulwin, Mitesh V Shah
BACKGROUND: The Triple Aim is defined as: improving the patient experience of care, improving the health of populations, and reducing the per capita cost of health care. The purpose of this analysis was to evaluate the economic value of a new neurosurgical technique, the BrainPath™ approach, for use in patients with subcortical tumors and intracerebral hemorrhage (ICH). METHODS: Inpatient length of stay (LOS) data were collected for ICH and brain tumor surgical patient cases between August 2013 and November 2015...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/28892957/risk-of-gerd-with-diabetes-mellitus-hypertension-and-bronchial-asthma-a-hospital-based-retrospective-cohort-study
#8
Sitara Nandyal, Sweta Suria, Bharti Chogtu, Dipanjan Bhattacharjee
INTRODUCTION: The rise in Gastro-Esophageal Reflux Disease (GERD) prevalence appears to have coincided with a simultaneous increase in the prevalence of diabetes mellitus, hypertension and bronchial asthma amongst the Indian population. Despite being evaluated extensively for their role as a risk factor for GERD, till date this relationship has remained a debatable one. Moreover, literature available on such studies conducted within Indian population remains scarce. AIM: The aim of the present study was to examine the risk of developing GERD in patients suffering from diabetes mellitus, hypertension and asthma in a Southern Indian population...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28887342/population-health-management-review-of-concepts-and-definitions
#9
Meghan Swarthout, Martin A Bishop
PURPOSE: The terms population health, population health improvement, and population health management are discussed. SUMMARY: A key concept in defining population health activities is clearly delineating the population(s) of focus. The Institute for Healthcare Improvement's (IHI's) Triple Aim Initiative uses the term population health management to describe the work by healthcare organizations to improve outcomes for individual patients to maximize population health...
September 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28881682/inhibition-of-fak-kinase-activity-preferentially-targets-cancer-stem-cells
#10
Vihren N Kolev, Winnie F Tam, Quentin G Wright, Sean P McDermott, Christian M Vidal, Irina M Shapiro, Qunli Xu, Max S Wicha, Jonathan A Pachter, David T Weaver
Because cancer stem cells (CSCs) have been implicated in chemo-resistance, metastasis and tumor recurrence, therapeutic targeting of CSCs holds promise to address these clinical challenges to cancer treatment. VS-4718 and VS-6063 are potent inhibitors of focal adhesion kinase (FAK), a non-receptor tyrosine kinase that mediates cell signals transmitted by integrins and growth factor receptors. We report here that inhibition of FAK kinase activity by VS-4718 or VS-6063 preferentially targets CSCs, as demonstrated by a panel of orthogonal CSC assays in cell line models and surgically resected primary breast tumor specimens cultured ex vivo...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881658/decitabine-vorinostat-combination-treatment-in-acute-myeloid-leukemia-activates-pathways-with-potential-for-novel-triple-therapy
#11
Christine S Young, Kathryn M Clarke, Laura M Kettyle, Alexander Thompson, Ken I Mills
Despite advancements in cancer therapeutics, acute myeloid leukemia patients over 60 years old have a 5-year survival rate of less than 8%. In an attempt to improve this, epigenetic modifying agents have been combined as therapies in clinical studies. In particular combinations with Decitabine and Vorinostat have had varying degrees of efficacy. This study therefore aimed to understand the underlying molecular mechanisms of these agents to identify potential rational epi-sensitized combinations. Combined Decitabine-Vorinostat treatment synergistically decreased cell proliferation, induced apoptosis, enhanced acetylation of histones and further decreased DNMT1 protein with HL-60 cells showing a greater sensitivity to the combined treatment than OCI-AML3...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28874908/application-of-the-intuitionistic-fuzzy-intercriteria-analysis-method-with-triples-to-a-neural-network-preprocessing-procedure
#12
Sotir Sotirov, Vassia Atanassova, Evdokia Sotirova, Lyubka Doukovska, Veselina Bureva, Deyan Mavrov, Jivko Tomov
The approach of InterCriteria Analysis (ICA) was applied for the aim of reducing the set of variables on the input of a neural network, taking into account the fact that their large number increases the number of neurons in the network, thus making them unusable for hardware implementation. Here, for the first time, with the help of the ICA method, correlations between triples of the input parameters for training of the neural networks were obtained. In this case, we use the approach of ICA for data preprocessing, which may yield reduction of the total time for training the neural networks, hence, the time for the network's processing of data and images...
2017: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/28874148/evaluating-a-dutch-cardiology-primary-care-plus-intervention-on-the-triple-aim-outcomes-study-design-of-a-practice-based-quantitative-and-qualitative-research
#13
Tessa C C Quanjel, Marieke D Spreeuwenberg, Jeroen N Struijs, Caroline A Baan, Dirk Ruwaard
BACKGROUND: In an attempt to deal with the pressures on the health-care system and to guarantee sustainability, changes are needed. This study focuses on a cardiology primary care plus intervention. Primary care plus (PC+) is a new health-care delivery model focused on substitution of specialist care in the hospital setting with specialist care in the primary care setting. The intervention consists of a cardiology PC+ centre in which cardiologists, supported by other health-care professionals, provide consultations in a primary care setting...
September 6, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28873225/chronic-hepatitis-c-increases-the-risk-of-chronic-kidney-disease-ckd-while-effective-hcv-treatment-decreases-the-incidence-of-ckd
#14
Haesuk Park, Chao Chen, Wei Wang, Linda Henry, Robert L Cook, David R Nelson
We aimed to assess the risk of chronic kidney disease (CKD) in chronic hepatitis C virus (HCV) infected patients and the incidence reduction of CKD after receipt of HCV treatment. We also evaluated the risk of membranoproliferative glomerulonephritis (MPGN) and cryoglobulinemia in chronic HCV patients. A retrospective cohort analysis of the Truven Health MarketScan Database (2008-2015) in the United States was conducted. In a cohort of 56,448 HCV-infected patients and propensity score (1:3) matched 169,344 non-HCV patients, we examined the association of HCV infection with the incidence of CKD...
September 5, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28870892/physical-needs-of-long-term-cancer-patients
#15
REVIEW
Paolo Tralongo, Maria Giovanna Pescarenico, Antonella Surbone, Sebastiano Bordonaro, Massimiliano Berretta, Annamaria DI Mari
The enormous success in the therapeutic area of oncology has allowed achieving a number of long-term survival patients unthinkable until a few decades ago. The number of cancer survivors in the world has, in fact, almost tripled in the last decade alone. Anticancer therapies, including those of the latest generation, aimed at targeting also the chronicity of the disease, are not free from side-effects, especially when used in the long term. This scenario should lead to development of follow-up programs with the purpose of assessing long-term effects related to cancer treatments, in addition to the early detection of any relapse or a second tumor...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28870198/up-modulation-of-plc-%C3%AE-2-reduces-the-number-and-malignancy-of-triple-negative-breast-tumor-cells-with-a-cd133-epcam-phenotype-a-promising-target-for-preventing-progression-of-tnbc
#16
Federica Brugnoli, Silvia Grassilli, Paola Lanuti, Marco Marchisio, Yasamin Al-Qassab, Federica Vezzali, Silvano Capitani, Valeria Bertagnolo
BACKGROUND: The malignant potential of triple negative breast cancer (TNBC) is also dependent on a sub-population of cells with a stem-like phenotype. Among the cancer stem cell markers, CD133 and EpCAM strongly correlate with breast tumor aggressiveness, suggesting that simultaneous targeting of the two surface antigens may be beneficial in treatment of TNBC. Since in TNBC-derived cells we demonstrated that PLC-β2 induces the conversion of CD133(high) to CD133(low) cells, here we explored its possible role in down-modulating the expression of both CD133 and EpCAM and, ultimately, in reducing the number of TNBC cells with a stem-like phenotype...
September 4, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28869699/fourteen-day-high-dose-esomeprazole-amoxicillin-and-metronidazole-as-third-line-treatment-for-helicobacter-pylori-infection
#17
Ignasi Puig, Jesús M González-Santiago, Javier Molina-Infante, Jesús Barrio, Maria Teresa Herranz, Alicia Algaba, Manuel Castro, Javier P Gisbert, Xavier Calvet
INTRODUCTION: The efficacy of currently recommended third-line therapies for Helicobacter pylori is suboptimal, even that of culture-guided treatments. Resistance to multiple antibiotics is the major factor related to treatment failure. The aim of this study was to evaluate the effectiveness and safety of a 14-day therapy using high-dose of amoxicillin, metronidazole and esomeprazole. MATERIAL AND METHODS: Multicenter open-label study as a register in routine clinical practice in patients with two previous failures of eradication therapy...
September 4, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28869621/influence-of-fibre-reinforcement-on-selected-mechanical-properties-of-dental-composites
#18
Agata M Niewczas, Jolanta Zamościńska, Aneta Krzyżak, Daniel Pieniak, Agata Walczak, Grzegorz Bartnik
PURPOSE: For splinting or designing adhesive bridges, reconstructive composite structures with increased mechanical properties owing to embedded reinforcement fibres are used. The aim of this article was to determine the influence of glass and aramid fibres on the mechanical strength of composites reinforced with these fibres. METHODS: Two polymer-ceramic microhybrid materials: Boston and Herculite were tested. Three types of reinforcement fibres were used: aramid (Podwiązka) with a single layer weave, a single layer weave glass fibre (FSO) and triple layer weave glass fibre (FSO evo)...
2017: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/28868934/business-model-framework-applications-in-health-care-a-systematic-review
#19
Jens Jacob Fredriksson, Pamela Mazzocato, Rafiq Muhammed, Carl Savage
It has proven to be a challenge for health care organizations to achieve the Triple Aim. In the business literature, business model frameworks have been used to understand how organizations are aligned to achieve their goals. We conducted a systematic literature review with an explanatory synthesis approach to understand how business model frameworks have been applied in health care. We found a large increase in applications of business model frameworks during the last decade. E-health was the most common context of application...
January 1, 2017: Health Services Management Research
https://www.readbyqxmd.com/read/28868126/repeated-systemic-administration-of-the-cinnamon-essential-oil-possesses-anti-anxiety-and-anti-depressant-activities-in-mice
#20
Reyhaneh Sohrabi, Nasim Pazgoohan, Hasan Rezaei Seresht, Bahareh Amin
OBJECTIVES: The present study aimed to evaluate the putative antidepressant and anti-anxiety effects of the cinnamon essential oil when administered acute (for 3 doses) and sub-acute (for 14 days) to mice. MATERIALS AND METHODS: In an acute experimental study, forced swim test (FST) was conducted to evaluate the antidepressant-like behavior of animals treated with the intraperitoneal (IP) essential oil of cinnamon in triple doses (0.5, 1, and 2 mg/kg). In a sub-acute study (14 days in 24-hr intervals) antidepressant-like effects of essential oil (0...
June 2017: Iranian Journal of Basic Medical Sciences
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